TWI434670B - Multi-channel physiological signal measure system and method thereof - Google Patents

Description

Multi-channel physiological signal measurement system and method

The invention relates to a measurement system and method for physiological signals, and in particular to a measurement system and method for simultaneously measuring physiological signals by multiple channels.

In recent years, although material life has been much better than in the past, the pressure of competition has also increased, and the mortality caused by brain diseases has therefore been among the top reasons for the death of Chinese people. Therefore, the development of brain wave measuring devices to provide physicians to diagnose diseases and related researchers to interpret patient diseases has become an important trend in the future. However, the brainwave signal is quite weak, and it is very susceptible to interference from the internal, external, and physiological signals of the subject. This makes the signal measurement difficult. For example, the interference signal may include problems with the electronic components themselves, and circuit wiring. Poor and the patient's myoelectric signal, ECG signal, and so on.

For example, since the common mode noise and environmental noise in the human body are much larger than the brain wave signal, the instrument amplifier was used as the brain wave signal measurement front-end amplifier to offset the common mode noise, but this Another problem arises. There is a DC bias between the skin and the electrode patch. This DC bias limits the gain of the amplifier, which makes the past physiological signal measuring instruments unable to accurately measure the brain wave signal. Lead to misjudgment by physicians and related researchers.

In addition, the brain wave signal is actually a mixed signal including different frequency bands such as α wave, β wave or γ wave. Therefore, multi-channel signal measuring instruments that can simultaneously observe multi-band signals have become one of the keys to studying brain wave signals, but this will inevitably increase the difficulty in circuit design of signal measuring instruments and signal interference between channels. The problem, therefore, the current brain wave signal measuring device on the market is still based on single channel measurement.

The invention provides a multi-channel physiological signal measuring system, which can effectively reduce the DC bias of the skin and the electrode patch and the problem of noise interference during measurement. It is also possible to measure multiple physiological signals simultaneously to assist the physician in diagnosing the disease and the relevant researchers interpreting the patient's disease.

Embodiments of the present invention provide a multi-channel physiological signal measurement system, including a signal input module, a pre-processing module, a digital processing module, and a terminal device. The signal input module is configured to measure the physiological signal and the reference voltage, and then output to the pre-processing module for signal preamplification. After the signal is preamplified, it is output to the digital processing module for signal amplification and signal conversion. The last digital processing module outputs the digital physiological signal to the terminal device to display the result.

The embodiment of the invention provides a multi-channel signal measurement method, which comprises acquiring a complex array physiological signal by using a signal input module. The pre-processing module respectively provides amplification processing on the physiological signals to relatively output the array of physiological amplification signals. And receiving the physiological amplification signals through the digital processing module, and outputting at least one of the physiological amplification signals in a time division multiplexing manner to perform signal conversion and then output the digital physiological signals.

In summary, the present invention utilizes the signal input module and the pre-processing module to effectively solve the DC bias and signal interference problems, and utilizes the parameter setting of the digital processing module to design different physiological signal frequency bands. Simultaneous measurement of multi-channel physiological signals. Compared with the conventional physiological signal measurement system, the present invention can provide a more reliable basis for physician diagnosis and related researchers to interpret the patient's disease.

The detailed description of the present invention and the accompanying drawings are to be understood by the claims The scope is subject to any restrictions.

[Embodiment of Multichannel Physiological Signal Measurement System]

Please refer to FIG. 1. FIG. 1 is a block diagram of a multi-channel physiological signal measurement system according to an embodiment of the present invention. The multi-channel physiological signal measurement system includes a signal input module 10, a pre-processing module 20, a digital processing module 30, and a terminal device 40. The signal input module 10 includes a physiological sensor 110, a signal transmission channel 120, and a reference voltage transmission channel 130. The pre-processing module 20 includes a plurality of preamplifying units 210. The terminal device 40 includes a human machine operation interface 401.

After the physiological sensor 110 of the signal input module 10 obtains the physiological signal from the subject, the physiological signal is outputted to the preamplifier unit 210 through the signal transmission channel 120, and the preamplifier unit 210 is output through the reference voltage transmission channel 130. The required reference voltage. The current amplification unit 210 receives the physiological signal and the reference voltage, performs a pre-amplification signal amplification process to obtain a physiological amplification signal, and outputs the physiological amplification signal to the digital processing module 30. After the digital processing module 30 receives the physiological signals transmitted from the preamplifier units 210, it performs signal amplification, signal conversion and the like. Finally, the man-machine interface 401 output to the terminal device 40 displays the result.

It is particularly noteworthy that the digital processing module 30 is controlled by the instructions of the terminal device 40. That is to say, the user can input parameters (for example, magnification, filter frequency, etc.) through the terminal device 40, and then transmit the parameter command to the digital processing module 30 for setting, and the digital processing module 30 performs the setting according to the parameter. After the signal processing, after the processing is completed, the physiological signal result is output to the terminal device 40.

In this embodiment, the physiological sensor 110 is substantially adhered to the skin. The electrode patch is not limited to the present invention. For example, the physiological sensor 110 may also be a sensor that measures the physiological signal such as a pulse counter or an acceleration gauge.

In this embodiment, the signal transmission channel 120 is configured to provide a channel for the physiological sensor 110 to transmit the measured physiological signal to the preamplifier unit 210. The reference voltage transmission channel 130 is a channel for transmitting a reference voltage to the preamplifier unit 210, which is substantially a DRL circuit (Driven Right Leg Circuit) and a circuit channel to which the reference circuit is coupled. It is to be noted that the function of the reference voltage transmission channel 130 is not a limitation of the present invention and is only one embodiment of the present invention.

When the physiological signal is equivalently measured, since the subject is not connected to the ground to provide a ground potential, the common mode potential of the human body affects the brain wave signal. Therefore, the potential measured by one of the physiological sensors (for example, the potential of the right foot) is used as the reference voltage of the pre-processing module 20 after passing through the reference voltage transmission channel 130. The reference voltage can avoid the DC bias generated between the skin and the electrode patch, so that the pre-processing module 20 can be filtered out of the common mode noise without being affected by the amplification gain being limited. It is worth mentioning that the use of the reference voltage transmission channel 130 does not limit the invention accordingly. That is to say, even if the reference voltage transmission channel 130 is not provided with the reference voltage to the pre-processing module 20, the present invention has the function of physiological signal measurement.

In this embodiment, the pre-processing module 20 includes a plurality of preamplifying units 210. Each of the signal transmission channels 120 and the reference voltage transmission channel 130 are coupled to their corresponding preamplifier units 210. For example, the first signal transmission channel 120 (CH1) transmits the physiological signal to the corresponding first preamplifier unit 310 and the second signal transmission channel 120 (CH2) to transmit the physiological signal to the corresponding second preamplifier unit. 310, etc., and so on, will not be detailed here.

Please refer to FIG. 2 , which is a block diagram of a pre-amplification unit 210 of the pre-processing module 20 according to an embodiment of the present invention, and please refer to FIG. 1 . The preamplifier unit 210 includes a differential amplifying unit 211, a filtering unit 213, and a level adjusting unit 215. The signal input end of the differential amplifying unit 211 is coupled to the signal transmission channel 120, the reference voltage input end of the differential amplifying unit 211 is coupled to the reference voltage transmission channel 130, and the signal output end of the differential amplifying unit 211 and the filtering unit are coupled. The input end of 213 is coupled. The output of the filtering unit 213 is coupled to the input of the level adjusting unit 215. The output of the level adjustment unit 215 is coupled to the digital processing module 30.

The circuit of the differential amplifying unit 211 is a circuit that can be driven by a single power source, as shown in FIG. It is composed of an instrumentation amplifier 2111, first and second alternating current signal coupling elements 2112 and 2112', and a bias input unit 2113. The first and second AC coupling units 2112 and 2112' are respectively connected to the first input end and the second input end of the instrumentation amplifier 2111, and the first AC signal coupling unit 2112 includes a first capacitor C1 and a first resistor R1. The first end of the first capacitor C1 receives a differential signal, the second end of the first capacitor C1 is connected to the first end of the first resistor R1 and the first input end, and the second AC signal coupling unit 2112' includes the second end. a capacitor C1' and a second resistor R1', wherein the first end of the second capacitor C1' receives the differential signal, and the second end of the second capacitor C1' is coupled to the first end of the second resistor R1' and the meter amplifying component 2111 The second input terminals, that is, the first AC and second AC coupling units 2112 and 2112' can respectively constitute a high-pass filter circuit by capacitors C1, C1' and resistors R1, R1'.

The bias input unit 2113 is connected to the feedback terminal of the instrumentation amplifier 2111, and is respectively connected to the first and second AC coupling units 2112 and 2112'. The bias input unit 2113 includes a third resistor R2, a fourth resistor R3, and a fifth. a resistor R3' and a third capacitor C2, wherein the first end of the third resistor R2 receives the reference voltage The second end of the third resistor R2 is connected to the second end of the first resistor R1, the second end of the second resistor R1' and the first end of the third capacitor C2, The second end of the third capacitor C2 is connected to the first end of the fourth resistor R3 and the first end of the fifth resistor R3', and the second end of the fourth resistor R3 and the second end of the fifth resistor R3' are respectively connected to the meter The amplifier and the two ends of the third resistor R2 are connected to the reference voltage Vcc/2 and the common mode point A. In the present embodiment, the reference voltage Vcc/2 is the voltage supplied from the reference voltage transmission channel 130 to adjust the input offset voltage value of the differential input signal input to the instrumentation amplifier 2111.

In this embodiment, the first and second AC signal coupling units 2112 and 2112' of the circuit of the differential amplifying element 211 can receive the physiological signal from the human body, that is, the physiological signal provided by the signal transmission channel 120. The DC and low frequency components of the physiological signal are filtered by the high-pass filter circuit composed of the capacitors C1 and C1' of the first and second AC coupling units 2112 and 2112' and the resistors R1 and R1', respectively, to respectively allow the physiological signals to be respectively The high frequency components pass through and pass to the B and B' points. Thereby, the low-frequency noise interference in the AC differential signal can be filtered out, and the high-frequency component of the differential signal is input to the B and B' points. Moreover, the low-pass filter circuit composed of the resistors R1, R1' and the capacitor C2 limits the high-frequency components of the AC differential signal to the B and B' points to increase the input impedance of the instrumentation amplifier 2111 and increase the total Mode rejection ratio.

In addition, the instrumentation amplifier 2111 can generate a common mode signal and transmit it to the high-pass filter circuit composed of the capacitor C2 and the third resistor R2 through the resistors R3 and R3' to filter out the DC component of the common mode signal and transmit it to point A. The DC bias signal is the voltage division principle of the reference voltage Vcc/2 through the resistor R2 and R1, R1', which can generate a DC bias signal at point A. Thereby, the common mode signal and the DC bias signal can be coupled at point A to form a common mode signal. In this embodiment, a total of The analog signal is a feedback signal generated by the instrumentation amplifier 2111, and can be coupled with the differential signal to generate a common mode offset through the instrumentation amplifier 2111.

It should be noted that, in this embodiment, the amplification gain of the differential amplifying unit is set to 1000 times, and the original 1-150 μV physiological signal can be amplified to between 1-150 mV, but the amplification gain ratio is not the present invention. The limitation is only to avoid the instrumentation amplifier 2111 in this embodiment, which may not operate normally because the output voltage is saturated or too small.

Referring to FIG. 1 and FIG. 2 simultaneously, the filtering unit 213 includes a high pass filter 2131 and a low pass filter 2132. After the physiological signal amplified by the differential amplifying unit 211 is input to the filtering unit 213, the low-frequency noise filtering of 0.16 Hz is performed through the high-pass filter 2131, and then 100 Hz through the low-pass filter 2132 ( Hz) high frequency noise filtering. The above-mentioned high-pass and low-pass filter order and noise filtering range are only examples of the present invention. In addition, in the embodiment, the high-pass filter 2131 is substantially a second-order high-pass filter, and the low-pass filter 2132 is an eighth-order low-pass filter. However, the order setting is only It is an embodiment of the invention. It should be noted that the filtering range, order of the filtering unit 213, and the order of the high and low pass filters are not intended to limit the present invention.

Referring to FIG. 1 and FIG. 2 simultaneously, the physiological signal is filtered by the filtering unit 213 and output to the level adjusting unit 215. The level adjusting unit 215 raises the boosting signal potential to a positive potential, and then outputs the signal to the digital processing module 4. . The level adjusting unit 215 is not intended to limit the present invention. The level adjusting unit 215 is substantially a clamper, but a replacement circuit such as a boost converter or a shifter can also be used instead.

Please refer to FIG. 4 , which is a block diagram of a digital processing module 30 according to an embodiment of the present invention, with reference to FIG. 1 . Digital processing module 30 includes signal mixing The unit 310, the signal amplifying unit 330, the analog/digital converting unit 350, the digital signal processing unit 370, and the signal transceiving transmission interface 390. The input end of the signal mixing unit 310 is coupled to the output end of the pre-processing module 20, and the output end of the signal mixing unit 310 is coupled to the input end of the signal amplifying unit 330. The output of the signal amplifying unit 330 is coupled to the input of the analog/digital converting unit 350. The output of the analog/digital conversion unit 350 is coupled to the digital signal processing unit 370. The digital signal processing unit 370 is coupled to the terminal device 40 via the signal transceiving transmission interface 390.

After the pre-amplification of the physiological signal by the pre-processing module 20, the signal is first outputted to the signal mixing unit 310 to convert the signal, and then output to the signal amplifying unit 330 for signal amplification, and then output to the analog/digital conversion unit 350. Signal conversion. After the signal processing process is completed, the digital physiological signal is outputted through the signal transceiving transmission interface 390 to the terminal device 40 to display the result.

It should be noted that the signal mixing unit 310, the signal amplifying unit 330, and the analog/digital converting unit 350 are controlled by the digital signal processing unit 370. That is, when the digital signal processing unit 370 receives the parameter command set by the user in the terminal device 40 through the signal transceiving and transmitting interface 390, the digital signal processing unit 370 controls the signal mixing unit 310, the signal amplifying unit 330, and the analogy/ The parameter setting of the digital conversion unit 350.

In this embodiment, the signal mixing unit 310 receives the physiological signal that the signal sent from the pre-processing module 20 is multi-channel. The signal mixing unit 310 rearranges the signals into a serial signal by means of time division multiplexing (TDM).

For example, the user measures the alpha wave, the beta wave, and the gamma wave. The three signals are processed by the front end and transmitted to the input end of the signal mixing unit 310. There are three parallel and independent signals between them. The signal mixing unit 310 rearranges the three signals into a series of signals by means of time division multiplexing (TDM), and outputs the signals to the signal amplifying unit 330. It should be noted, however, that the signal mixing unit 310 is only one embodiment of the present invention and is not intended to be a limitation of the present invention. That is to say, the three parallel and independent signals are directly input to the signal amplifying unit 330 without being rearranged by the signal mixing unit 310, and the results of the three signals can still be displayed on the terminal device 40.

In addition, the time division multiplexing (TDM) arrangement adopted by the signal mixing unit 310 is performed by quickly switching channels for signal extraction and then rearranging into a serial signal. It should be noted that when a plurality of physiological signals are input to the signal mixing unit 310, the signal mixing unit 310 needs to set a minimum sampling frequency to avoid loss of information in the signal. That is to say, assuming that the lowest sampling frequency is 500 samples/s, the time to switch channels is at least 62.5 μs, so as to avoid the information contained in the signal not being completely captured.

In this embodiment, after receiving the signal transmitted by the signal mixing unit 310, the signal amplifying unit 330 performs functions such as amplification and filtering, and then outputs the signal to the analog/digital conversion unit 350. However, the parameters of these functions can be set by the user on the terminal device 40. For example, the user sets the magnification on the terminal device 40 to 100 times and the filter frequency to 10-20 Hz. The parameters set on the computer are transmitted to the digital signal processing unit through the signal transmission and transmission interface 390. 370, the digital signal processing unit 370 is thus set to the signal amplifying unit 330 to give a magnification gain of 100 times and a filtering range of 10-20 Hertz (Hz) when it receives the physiological signal.

Referring to FIG. 1, the terminal device 40 includes a human machine operation interface 401. In this embodiment, the human-machine interface 401 includes a control interface for magnification and channel selection, a digital filtering and display control interface, and a physiological signal waveform display. The interface and the like do not limit the function of the human-machine interface 401. Further, in the present embodiment, although the terminal device 40 is substantially a computer, the terminal device 40 may be replaced by a mobile phone and various display devices. Therefore, the present invention does not limit the type of the terminal device 40.

[Another embodiment of a multi-channel physiological signal measuring system]

Please refer to FIG. 5. FIG. 5 is a structural diagram of another embodiment of a multi-channel physiological signal measurement system, and please refer to FIG. 5 is different from FIG. 1 in that the signal transmission channel 120 of FIG. 5 includes a primary signal transmission channel 120' and a reference signal transmission channel 120", and the preamplifier unit 210 includes a primary signal preamplifier unit 210' and a reference signal preamplifier. Amplifying unit 210". The primary signal transmission channel 120' and the primary signal preamplifier unit 210' are used to transmit and receive target physiological signals, such as brainwave signals, that are to be measured. The reference signal transmission channel 120" and the reference signal preamplifier unit 210" are used to transmit and receive other physiological signals, such as myoelectric signals, eye movement signals, etc., which can be used to assist in verifying that the target physiological signals are not interfered.

For example, when measuring the brain wave signal of the test subject, the physiological sensor 110 responsible for measuring the brain wave signal transmits the brain wave signal to the main signal preamplifier unit 210' through the main signal transmission channel 120'. Signal processing, and the reference voltage transmission channel 130 reduces the interference of the common mode potential on the brain wave signal by adding a reference voltage. At the same time, the physiological sensor 110 responsible for measuring other physiological signals (such as myoelectric, eye movement, etc.) transmits other physiological signals to the reference signal preamplifier unit 210 via the reference signal transmission channel 120" for signal processing. , to prove whether the brain wave signal measurement is interfered by other physiological signals.

However, it is particularly important to note that the primary signal preamplifier unit 210' is configured to receive and amplify the target physiological signal, so that the reference voltage is added to the primary signal preamplifier unit 210' through the reference voltage transmission channel 130 to reduce the total The interference of the mode potential on the target physiological signal. However, this is only an embodiment of the present invention, and the present invention is not limited thereto. That is, even if the main signal preamplifier unit 210' does not add a reference voltage, or the reference voltage is added to the reference signal preamplifier unit 310" to add the reference voltage, the present invention still has the effect of physiological signal measurement.

In addition, from the above description of the embodiment, a flow of a multi-channel signal measurement method can be summarized, as shown in FIG. 6. First, the physiological signal and the reference voltage are obtained by the signal input module 10 (step S601), and then input to the differential amplifying unit 211 for noise suppression and signal amplification (step S603). Then, the filtering unit 213 filters out the noise (step S605), and raises the signal potential using the level adjusting unit 215 (step S607). Then, the signal is transmitted to the signal mixing unit 310 to perform the function of capturing and rearranging the multi-channel signals into a series of signals (step S609). Thereafter, the serial signal is transmitted to the signal amplifying unit 330 and the analog/digital converting unit 350 for signal amplification and conversion into a digital signal (step S611). Finally, the signal is transmitted to the terminal device 40 by the signal transceiving transmission interface 390 (step S613). The physiological signal result and each parameter setting value are displayed on the human-machine interface 401 of the terminal device 40 for reference by the user (step S615).

Incidentally, the digital signal processing function performed in steps S609 and S611 is controlled by the digital signal processing unit 370. That is, when the digital signal processing unit 370 receives the parameter setting command from the user transmitted from the signal transceiving transmission interface 390, the channel selection and sampling frequency of the signal mixing unit 310 are set (step S609) and the setting signal amplifying unit 330. The signal magnification and the filtering range (step S611).

[Possible effects of the examples]

In summary, the present invention provides a multi-channel physiological signal measurement system including a signal input module, a pre-processing module, a digital processing module, and a terminal device. Through the signal input module and the pre-processing module, the problem of signal interference caused by the DC bias voltage and the common mode potential is effectively solved. After the parameters of the digital processing module are set by the terminal device, the signals can be applied to different physiological signal frequency bands. Designed to achieve simultaneous multi-channel physiological signal measurement, which in turn provides a reliable basis for physician diagnosis and related research personnel to interpret patient disease.

The above description is only an embodiment of the present invention, and is not intended to limit the scope of the invention.

1, 1a‧‧‧Multichannel physiological signal measurement system

10, 10a‧‧‧ signal input module

110‧‧‧ Physiological sensor

120‧‧‧Signal transmission channel

120’‧‧‧ main signal transmission channel

120”‧‧‧reference signal transmission channel

130‧‧‧reference voltage transmission channel

20, 20a‧‧‧ pre-processing module

210‧‧‧Preamplifier

210’‧‧‧ main signal preamplifier

210”‧‧‧reference signal preamplifier

211‧‧‧Differential amplification unit

2111‧‧‧Instrument Amplifier

2112‧‧‧First AC signal coupling unit

2112'‧‧‧Second AC signal coupling unit

2113‧‧‧ bias input unit

213‧‧‧Filter unit

2131‧‧‧High-pass filter

2132‧‧‧Low-pass filter

215‧‧ ‧ level adjustment unit

30‧‧‧Digital Processing Module

310‧‧‧Signal mixing unit

330‧‧‧Signal amplification unit

350‧‧‧ analog digital conversion unit

370‧‧‧Digital Signal Processing Unit

390‧‧‧Signal transmission and transmission interface

40‧‧‧ Terminal devices

401‧‧‧Man-machine interface

S601~S615‧‧‧ Process steps

1 is a block diagram of a multi-channel physiological signal measurement system according to an embodiment of the present invention; FIG. 2 is a block diagram of a pre-processing module according to an embodiment of the present invention; FIG. 3 is an embodiment of the present invention. FIG. 4 is a block diagram of a digital processing module according to an embodiment of the present invention; FIG. 5 is a block diagram of a multi-channel physiological signal measuring system according to an embodiment of the present invention; And FIG. 6 is a flowchart of a multi-channel physiological signal measurement method according to an embodiment of the present invention.

1. . . Multi-channel physiological signal measurement system

10. . . Signal input module

110. . . Physiological sensor

120. . . Signal transmission channel

130. . . Reference voltage transmission channel

20. . . Pre-processing module

210. . . Preamplifier unit

30. . . Digital processing module

40. . . Terminal device

401. . . Man-machine interface

Claims (6)

A multi-channel physiological signal measuring system includes: a signal input module for receiving a complex array of physiological signals and a reference voltage, the signal input module comprising a plurality of signal transmission channels and a reference voltage transmission channel, the signal transmission The channel outputs the physiological signal to the pre-processing module, the reference voltage transmission channel outputs the reference voltage required by the preamplifier unit, the reference voltage transmission channel is a DRL circuit; and a pre-processing module coupled to the The signal input module has a plurality of preamplifier units, and each of the preamplifier units receives a set of the physiological signals and provides signal amplification processing to output a set of physiological amplification signals. And a digital processing module coupled to the pre-processing module to receive at least one of the group of physiological amplification signals output by the preamplifier units in a time division multiplexing manner and received The physiological amplification signal provides signal amplification by a signal amplification unit and signal conversion by a analog/digital conversion unit to relatively output a set of digits. a physiological signal; wherein the preamplifier unit has a differential amplifying unit that amplifies the physiological signal, the differential amplifying unit includes: an instrumentation amplifier having a first input end and a second input end and a feedback a first alternating current signal coupling unit includes a first capacitor and a first resistor, wherein the first end of the first capacitor receives a differential signal, and the second end of the first capacitor is coupled to the first resistor The first end and the first input end; a second AC signal coupling unit, comprising a second capacitor and a second resistor, wherein the first end of the second capacitor receives the differential signal, the second The second end of the capacitor is connected to the first end of the second resistor and the second input end, the differential signal is the physiological signal; and a bias input unit includes a third resistor, a fourth resistor, and a a fifth resistor and a third capacitor, wherein the first end of the third resistor receives a voltage provided by the reference voltage transmission channel, and the second end of the third resistor is coupled to the second end of the first resistor, the first a second end of the second resistor and a first end of the third capacitor, the second end of the third capacitor being connected to the first end of the fourth resistor and the first end of the fifth resistor, the fourth resistor The second end and the second end of the fifth resistor are respectively connected to the instrumentation amplifier, and the bias input unit adjusts an input offset voltage of the differential signal input to the instrumentation amplifier according to the voltage received by the first end of the third resistor. value. The multi-channel physiological signal measuring system of claim 1, wherein the preamplifying unit further comprises: a filtering unit coupled to the differential amplifying unit; and a level adjusting unit coupled to the A filtering unit for providing signal level adjustment. The multi-channel physiological signal measuring system of claim 1, wherein the digital processing module comprises: a digital signal processing unit; a signal mixing unit coupled to the digital signal processing unit, and based on the digital The control unit of the signal processing unit receives the set of physiological amplification signals, and outputs at least one of the group of physiological amplification signals in a time division multiplexing manner; the signal amplification unit is coupled to the digital signal processing unit and the signal mixing And providing an amplification process to the signal mixing unit output signal according to the control of the digital signal processing unit; The analog/digital conversion unit is coupled to the digital signal processing unit and the signal amplifying unit, and provides analog signal processing for the signal output from the signal amplifying unit according to the control of the digital signal processing unit. The multi-channel physiological signal measurement system of claim 3, further comprising: a terminal device having a human-machine interface for providing a setting parameter to the digital processing module, The digital signal processing unit controls the magnification of the signal amplifying unit according to the setting parameter. A method for measuring a multi-channel physiological signal of a multi-channel physiological signal as described in claim 1, comprising: obtaining a complex array of physiological signals through the signal input module; and separately using the pre-processing module The physiological signals of the group provide amplification processing to output the complex array of physiological amplification signals; receive the physiological amplification signals of the groups through the digital processing module, and output at least one of the group of physiological amplification signals in a time division multiplexing manner to perform The signal is converted to output a set of digital physiological signals; the first alternating current signal coupling unit and the first alternating current signal coupling unit are symmetric high-pass filter circuits to filter out a low frequency noise of the set of physiological signals, and the Passing a high frequency component of one of the physiological signals; and coupling the voltage supplied by the bias voltage input unit to a common mode signal generated by the instrumentation amplifier to generate a common mode signal, and the instrumentation amplifier Amplification is performed to obtain the physiological amplification signal. The multi-channel physiological signal measurement method according to claim 5, wherein the digital processing module receives a setting parameter provided by a terminal device, and sets the signal mixing unit according to the setting parameter to divide the time. The working mode outputs the group of physiological amplification signals.