TWI362935B - Component for improving impaired insulin tolerance - Google Patents

Component for improving impaired insulin tolerance Download PDF

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Publication number
TWI362935B
TWI362935B TW96101345A TW96101345A TWI362935B TW I362935 B TWI362935 B TW I362935B TW 96101345 A TW96101345 A TW 96101345A TW 96101345 A TW96101345 A TW 96101345A TW I362935 B TWI362935 B TW I362935B
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TW
Taiwan
Prior art keywords
concentration
extract
complex
receptor
insulin
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TW96101345A
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Chinese (zh)
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TW200829264A (en
Inventor
Deching Chou
Jiunn Jye Chuu
Sunghsun Yu
Chiahsien Huang
Wanling Chen
Liang Hao Chang
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Taiyen Biotech Co Ltd
Univ Southern Taiwan Tech
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Priority to TW96101345A priority Critical patent/TWI362935B/en
Publication of TW200829264A publication Critical patent/TW200829264A/en
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  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines Containing Plant Substances (AREA)

Description

1362935 胰島素依賴型糖尿病又稱第i型糖尿病,其致病原因主 要是自體免疫疾病造成胰臟β細胞大量特異性破壞,導致胰 島素的完全缺乏。非胰島素依賴型糖尿病又稱第η型糖尿 病,其致病原因除先天的基因問題外,最主要的是現代人生 活型態的改變,飲食不均衡、肥胖、壓力、荷爾蒙失調以及 缺乏運動等,造成周邊組織(主要為肌肉與脂肪細胞)對胰島素 產生抗性,此時胰臟β細胞會代償性增加胰島素釋放導致高 胰島素血症,直到β細胞無法代償、無法對血糖做出適當的 反應,而造成血糖恆定異常、葡萄糖耐受性不良,長久下來 則造成胰臟β細胞衰竭’最終形成第I型糖尿病。 目前已對於胰島素一連串的訊息傳遞與作用已廣被研討 <識,而胰島素訊息傳遞的中斷或抑制,皆有導致糖尿病的 "Τ此性。騰島素訊息傳遞機轉與氧化物酶體增殖物活化受體_γ (peroxisome proliferat〇r_activated recept〇r_y,ppAR 杓胰島 素受體(Insulin recept0r)、胰島素受體基質(Insulin recept〇r substrate,IRS)及葡萄糖轉運蛋白_4(glut_4)有關。 騰島素受體和胰島素受體基質係用來刺激葡萄糖轉運蛋 白-4(GLUT-4)自細胞内轉至細胞膜上,將細胞外的葡萄糖運送 至J細胞内進行氡化代謝或肝醣合成作用,以調節企糖之恆定。 氧化物酶體增殖物活化受體_γ (ppAR-γ)係用來調控脂質 代謝機轉’包括脂肪酸傳輸、氧化或儲存。目前由實驗發現 騰島素作用也受到氧化物酶體增殖物活化受體_γ (PPAR_Y)的 調控。 第π型糖尿病的正規治療,係投以包括磺醯尿素類 71362935 Insulin-dependent diabetes mellitus, also known as type I diabetes, is mainly caused by autoimmune diseases that cause massive destruction of pancreatic beta cells, resulting in a complete deficiency of insulin. Non-insulin-dependent diabetes mellitus, also known as type η diabetes, is caused by innate genetic problems in addition to congenital genetic problems. Dietary imbalance, obesity, stress, hormonal imbalance, and lack of exercise, etc. Causes peripheral tissues (mainly muscles and fat cells) to be resistant to insulin. At this time, pancreatic β cells will compensate for the increase in insulin release leading to hyperinsulinemia until the beta cells are unable to compensate and cannot respond appropriately to blood sugar. The result is a constant abnormal blood glucose, poor glucose tolerance, and long-term pancreatic β-cell failure, which eventually leads to type I diabetes. At present, a series of messages and effects on insulin have been widely studied, and the interruption or inhibition of insulin signaling has led to diabetes. The Tengdaosu message transmitter is transferred to the peroxisome proliferator-activated receptor _γ (peroxisome proliferat〇r_activated recept〇r_y, ppAR 杓 insulin receptor (Insulin recept0r), insulin receptor matrix (Insulin recept〇r substrate, IRS) ) is associated with glucose transporter _4 (glut_4). The TB receptor and insulin receptor matrix are used to stimulate glucose transporter-4 (GLUT-4) to transfer from the cell to the cell membrane, transporting extracellular glucose. Deuteration or hepatic sugar synthesis is performed in J cells to regulate the constant glucose. Oxide proliferator-activated receptor γ (ppAR-γ) is used to regulate lipid metabolism, including fatty acid transport, Oxidation or storage. It has been experimentally found that the effect of temsin is also regulated by the oxidase proliferator-activated receptor γ (PPAR_Y). The regular treatment of π-type diabetes is based on the inclusion of sulfonamides.

Claims (1)

1362935 年10月"~丨8曰修JT替換頁I 十、申請專利範圍 1· 一種改善胰島素耐受性的複合物,包括一山苦瓜 (Momordica Charantia Linn)萃取物及一螺旋藻複合物之一 酒精萃取物’其中該山苦瓜萃取物及該螺旋藻複合物的重 量比係實質介於1 : 5至1 : 2之間。 2. 如申請專利範圍第1項所述之改善胰島素耐受性的複合 物,係一口服錠劑、一口服散劑或一口服液劑。 3. 如申請專利範圍第1項所述之改善胰島素耐受性的複合 物’更包括一載體、一添加劑、一辅劑或—包覆劑。 4. 一種可同時增加第Π型糖尿病患血液中氧化物酶體增殖 物活化受體 _γ (Per〇xis〇me pr〇Uferat〇r activated receptor-γ,PPAR_Y)、胰島素受體(Insulin recept〇r)、胰島 素受體基質(Insulin receptor substrate,IRs)及葡萄糖轉運 蛋白-4(GLUT-4)濃度的複合物,包括一山苦瓜萃取物及一 螺旋藻複合物之一酒精萃取物,其中該山苦瓜萃取物及該 螺旋藻複合物的重量比係實質介於1 : 5至〖:2之間。 5. 如申請專利範圍第4項所述之可同時増加第η型糖尿病 患血液中氧化物酶體增殖物活化受體-γ、胰島素受體、膜島 素受體基質及葡萄糖轉運蛋白-4濃度的複合物,係一口服 24 1362935 18日修正替換頁 錠劑、一口服散劑或一口服液劑。 6.如申請專利範圍帛4項所述之可同時增加第^型糖尿病 患血液中氧化物酶體增殖物活化受體_丫、胰島素受體、胰島 素受體基質及葡萄糖轉運蛋白_4濃度的複合物^更包括一 載體、一添加劑、一輔劑或一包覆劑。 7. -種可同時降低第n型糖尿病患血液中葡萄糖濃产、三 酸甘油脂濃度、姨島素濃度的複合物,包括一山苦瓜萃: 物及一螺旋藻複合物之-酒精萃取物,其中該山苦瓜萃取 物及該螺旋藻複合物的重量比係實質介於1: 5至之 間。 8.如申請專利範圍帛7項所述之可同時降低第辽型糖尿病 〜液中葡萄糖濃度、三酸甘油脂濃度、騰島素濃度的複 合物’係-口服錠劑、—口服散劑或一口服液劑。 9’如申明專利範圍第7項所述之可同時降低第π型糖尿病 患血液中葡萄糖濃度、三酸甘油脂濃度、胰島素;農度的複合 物’更包括—載體、-添加劑、一輔劑或一包覆劑。 25October 1362935"~丨8曰修JT replacement page I X. Patent application scope 1. A compound that improves insulin resistance, including Momordica Charantia Linn extract and a spirulina complex An alcoholic extract wherein the weight ratio of the extract of the bitter gourd and the spirulina complex is substantially between 1:5 and 1:2. 2. A compound for improving insulin resistance as described in claim 1 of the patent application is an oral lozenge, an oral powder or an oral liquid. 3. The composition for improving insulin resistance as described in claim 1 further comprises a carrier, an additive, an adjuvant or a coating agent. 4. A method for simultaneously increasing the levels of oxidase-activated receptor-γ (PPAR_Y) and insulin receptor (Insulin recept〇) in the blood of patients with type 2 diabetes mellitus r) a complex of an insulin receptor substrate (IRs) and a glucose transporter-4 (GLUT-4) concentration, comprising an extract of a bitter gourd extract and an alcoholic extract of a spirulina complex, wherein The weight ratio of the mountain bitter gourd extract and the spirulina complex is substantially between 1:5 and 〖:2. 5. As described in the fourth paragraph of the patent application, the oxidized proliferator-activated receptor-γ, insulin receptor, membrane receptor matrix and glucose transporter-4 in the blood of patients with type XX diabetes can be simultaneously added. The concentration of the complex is an oral 24 1362935 18-day modified replacement tablet, an oral powder or an oral solution. 6. As described in the scope of patent application 帛 4, it can simultaneously increase the concentration of oxidase-proliferating receptor receptor 丫, insulin receptor, insulin receptor matrix and glucose transporter _4 in the blood of patients with type 2 diabetes. The composite further comprises a carrier, an additive, an adjuvant or a coating agent. 7. A compound that simultaneously reduces the concentration of glucose in the blood, the concentration of triglyceride, and the concentration of sulphonin in patients with type n diabetes, including a bitter gourd extract: a substance and a spirulina complex - an alcohol extract Wherein the weight ratio of the extract of the bitter gourd and the spirulina complex is substantially between 1:5 and about. 8. As described in the scope of patent application 帛7, the complex of 'Liao type diabetes mellitus~ liquid glucose concentration, triglyceride concentration, and the concentration of Tengdasu can be reduced at the same time. Oral liquid. 9', as described in claim 7 of the scope of patents, can simultaneously reduce the blood glucose concentration, triglyceride concentration, insulin; the complex of agricultural degree', including - carrier, - additive, an adjuvant Or a coating agent. 25
TW96101345A 2007-01-12 2007-01-12 Component for improving impaired insulin tolerance TWI362935B (en)

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TW200829264A TW200829264A (en) 2008-07-16
TWI362935B true TWI362935B (en) 2012-05-01

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