TWI360509B - Cassette for assembling samples, spotting apparatu - Google Patents

Cassette for assembling samples, spotting apparatu Download PDF

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TWI360509B
TWI360509B TW94136458A TW94136458A TWI360509B TW I360509 B TWI360509 B TW I360509B TW 94136458 A TW94136458 A TW 94136458A TW 94136458 A TW94136458 A TW 94136458A TW I360509 B TWI360509 B TW I360509B
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sample
package
assembly
shaft
sample carrier
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TW94136458A
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TW200716470A (en
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Hideji Tajima
Tsutomu Asano
Junko Asahina
Mamiko Yoshida
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Universal Bio Research Co Ltd
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13605091360509

九、發明說明： 【發明所屬之技術領域】 本發明係關於將含有各種生物體物質之試料按 於絲線狀之試料載體上、並捲裝成為螺旋狀之試料 $積體之調整所使用之試料集積用匣且 集積化裝置。 ，、‘Μ裝置及試料 【先前技術】 之鹼基序列等生物體成 研發了有關測定收納反IX. EMBODIMENT OF THE INVENTION: TECHNICAL FIELD The present invention relates to a sample used for adjusting a sample containing various biological substances on a thread-shaped sample carrier and wound into a spiral sample The accumulation is used for the accumulation device. , Μ device and sample [previous technique] bases such as base sequences have been developed

本發明研究者曾經就釐定基因 分之方法及裝置從事研究開發，而 應之各種裝置。 …其中，以使用：在表面上於軸方向等距附著多數試料 並形成為棒狀之基礎構件經收納在透光性之細管而構成之 探針，或形成為絲線狀之試料載體之表面上在長方向以等 距附著有多數試料、並以螺旋狀捲裝至棒狀捲裝體上之試 料集積體經收納在吸管狀容器而成探針，在測定收納反應 上，對於減量使用含有各種檢驗用生物體成分之試料以及 心識目的生物體成分係具有效益，故使用將吸管狀容器及 "式料集積體予以組合而成之探針的收納反應測定係開始受 到應用（參考專利文獻1、2、3)。 使用該探針之收納反應測定法中，係將探針之下端部 插入收納有預先標識過之生物體成分之懸濁液之容器中， 吸引遠標識生物體成分之懸濁液至浸潰試料集積體之試料 載體捲繞部分（下文中，稱為核心部）之全體為止，從而使 附著於試料載體之檢測用生物體成分和標識生物體成分之 317545 5 1360509 結合性物質得以結合。 然後，從探、針之下端部排除經吸引之標識生物體成分 ^懸濁液’繼之’藉由進行洗淨液之吸引及排除而洗淨吸 官内部，洗除標識生物體成分之懸濁液之殘留液。 洗淨後，吸引測定用液體於吸管内，將探針在保持有 測定用液體之狀態下安裝於收納反應測定裝置中，並從探 針外部照射紫外光，使檢測用生物體成分和標識生物體成 77中之，，·口口性物質所結合位置之螢光物質發出榮光，藉由 感應該發光之感光部分測定從核心部整體發光之位置，由 所檢測位置辨識出標識生物體成分中之結合性物質，再從 所有經辨識出之結合性物質之組合敎目的物質。 处例如第45 ®所示’吸管⑴中收納有試料集積體⑺之 下’心使試料集積體（2)之核心部（2a)位於吸管⑴之粗 禮部（la)之下端部’俾使之容易接觸從細徑部（叫吸引而來 夜體為此，叹置在核心部pa)之前端部之帽蓋⑽)係以 φ Κτ留於形成在吸官⑴之粗徑部〇及)及細徑部（⑼之境 界4的縮小部分之方式而形成，另外，用於外嵌於為了壓 集積體(2)到該位置所使用之器具（未圖示）之前端部 、^柱狀柄（2c)係形成較核心部㈣細小之直徑，並以同軸 狀突設自試料集積體（2)之基部。 藉第46圖所示之點液裝置⑷’於預先捲裝配置於平 二，大Γ裝紅（3)之形成絲線狀之試料載體（因過細微無法識 -略其，使含有試料之溶液在多處總括性地加 寸者之後’將已附著有試料之試料載體以螺旋狀捲裝在 317545 6 1360509 核心部（2a)，從而形成上述試料集積體（2)。 —所使用之點液裳置⑷如第46圖所示，藉由複數之彈 黃（4a、...4a)設置在位於各導柱（扑、…扑）之最頂部之可浐 動部（4c)上，並安裝有略四方形狀之分配部⑺，該分配^ (5)之正下方設置有：組合有試料集積體（2)及捲裝有試料 ，之平板狀捲裝體（3)之£具⑹；以及該匿具⑹上所置、 没置有多數之孔（7a、...7a)之微平板狀容器⑺。 該點液裝置（4)中，在容器⑺之孔（7a、 收納懸濁有用以附著於試料载體之試料的液體’並放置^ 動部(4C)頂抗彈聲之彈將女裝有分配部(5)之可移 ⑺下面之各料端（_ ，而將突出在分配部 n ， 符触(未圖不，下文中稱為銷針)插入各孔 上附者有液體之後，佶玎贷么 1 升回到最初位置。 夕動州C)順著彈普彈推力而上 出容Ϊ二配1(5)上升到能取出容器⑺時，從11具⑹上取 將突二 可移動部(4c)頂抗彈簧彈推力往下壓，而 於捲面之各銷針，係從上方接觸到捲裝 體移至試料載體側而將附著於各銷針之下端部之液 然後，將可移動部(4c)順著 位置時，捲裝在捲裳體(3)之上升回到最初 向的4#裁體變成已附著試 317545 7 1360509 .料之狀態，而能予以取出。 • 欲使試料附著於位於捲裝體（3)之反側之試料載體 時’係將試料集積體（2)之配置位置設為相同位置而加以表 裡反轉後，再按照上述順序重複進行操作。 據此，將各試料附著固定於捲裝在捲裝體（3)之試料載 體之後\藉由從捲裝體（3)捲繞至試料集積體（2)之核心部 (2a)，就能形成收納於吸管（1)前狀態之試料集積體（2)。 鲁—將違试料集積體（2)自g具⑻取出，並從前端側收納於 吸管（1)，從而形成釐定目的生物體成分用之測定收納反應 使用之探針（參考專利文獻4)。 專利文獻 1 : WO02/045842 A1 專利文獻 2 : W099/003341 專利文獻 3 : W02/063300 A1 專利文獻4:曰本特願20〇3_177228號 按照已往之裝[點液用各種試料之懸濁液係收納於 鲁世界標準規格之48孔微平板（6排X 8行），96孔微平板（8 排X 12行，9mm間距），384孔微平板（“排父24行，45mm 間距）’ 1536孔微平板（32排x 48行，2 25mm間距）中。 因此，由於容器（7)之大小已定，所以將銷針插入各孔 (7&、…73)、附著所收納之液體、再將試料附著於所該配 置之試料載體之間距已被決定，試料載體之長度及試料集 積體（2)之大小也隨之變大，由於係依據微平板之孔數而決 定試料集積體（2)及收納該試料集積體（2)之吸管（1)之大 小’所以無法隨便使探針變小。 317545 1360509 又’由於容器（7)已固定’也無法增加更多之試料之配 置位置’所以不能提高試料配置之密度。 又，欲變更試料集積體（2)及吸管（1)之大小也無法做 到，所以例如該浸潰於試料集積體（2)之核心部（2a)之液量 會增多而無法予以減少，因此，欲使之成為相同濃度，液 中所含試料需要增加。 隨著試料集積體（2)及吸管（1)之尺寸，測定裝置之尺寸 也會變大，測定所需經費也增多。 又，在试料集積體（2)之核心部（2a)以螺旋狀捲裝試料 載體時，必須將試料載體均一地捲裝在核心部（2a)，所以 由於捲裝時之試料載體之鬆弛或滑動，彳艮難得到所期望之 均一性。 因此，收納反應測定在試料集積體（2)之製造裝置、測 定裝置及材料各方面有高成本之缺點存在。 【發明内容】 _ (本發明所欲解決之課題） 本發明係有鑑於已往技術中上述各項問題而研創者c ▲為解決該問題而具體設定之技術上之課題係為，提供一毛 :、料二積用H具、點液裝置以及試料集積化裝置，可 : = 载體於核心部’提高試料集積密度，使試料集， 此細衣小型化’隨之測定裝置也可以小型化，而可降令 枚、、内反應測定所需經費。 (用以解決課題之手段） 網羅所有認為有效解決上述課題所必要事項之試料漠 317545 9 ^60509 、積用匿具、點液裝置以及試料集積化裝置所構成具體課題 " 之解決手段如下所示。 有關本發明之試料集積用匠具之第一課題解決手段， 其特徵為，將試料集積體及捲裝體配置成，使試料載體從 捲裝有前述試料載體之捲裝體相對於試料集積體恒常以一 定角度反覆被柚出，同時形成為，可連接於使上述試料集 積體及上述捲裝體連動且予以同步驅動之驅動裳置。 錢上賴料⑽職具之第二課賴決手段，盆特 徵為，上述試料集積體係一體式地具備有：以一定間距分 離刻設螺旋狀溝而捲附試料載體於該溝所構成之核心部； 以及在該核心部之前端、以可接近遠離之方式連接而挟持 上述試料載體之前端部的頭部。 、關於上述試料集積用Ε具之第三課題解決手段，其特 徵為，將上述試料集積體做成，在上述核心部之後端部刻 二n# ’而藉由嵌人·^ G形環溝之〇形環挾持上述 _試料載體之後端部。 4關於上述試料集積用£具之第四課題解決手段，其特 d為包括·將上述試料集積體沿著其形狀以可於長方向 =之方式Μ嵌裝之本體中央部；以及使刻設在上述試 =术積體上之搞载體捲約平行於捲裝於上述捲 ^上之試㈣體’而將上述捲裝體以可旋轉之方式予以 對側方支承部；並且藉由該一對之側方支承部及 而邛„又置有各側方支承部之上述本體中央部而形成門 /史，可使上述試料載體能均一地從上述捲裝體捲裝到上 317545 1360509 述試料集積體上。 ，有關上述試料集積用匣具之第五課題解決手段，其特 ft為將用以使驅動轴能夠連接至上述試料集積體的開口 、又置在本體中央部之試料集積體嵌裝部之側面，並將 2乂於上K料集積體之旋轉而旋轉驅動之驅動軸連接於 前述捲裝體所用的開口設置在上述側方支承部之捲裝體抱 接部之側面，而形成為使上述試料集積體和上述捲裝體可 以連動。 明之點液裝置之第一課題解決手段，其特徵 二/、備有载置捲裝體用台座、直立設置於該底座之一個 2 口、-體設置在該架台上之導執、隨上述導執而上下移 動台、及設置在該移動台上而形成有能裝卸自如地 ί在二ΤΙ,嵌合部分的分配構件載置台’據此可使嵌 心、 之分配構件下降到上述捲裝體上，而將 =二職之行列狀而附著在捲裝於上述捲裝體之試= 上述裝置第二課題解決手段，其特徵為，在 上边木σ座及上述移動台之間，設 牡 向上方推壓，力的捲帶彈簧式彈性手段，當上:二: =下：時，藉該彈箐彈力將上述移動台保持於上二。 ㈣本4明之从集積化裝置之第 =其特徵為’具備有：用以載置以預定方向安 木積體及捲褒體的試料集積用匠且 K讨 旋輊夕f斗· ± 八且以依轴方向能自由 ^ 述捲裝體，同時可向該捲裝體❹以 ]] 317545 移動而形成之匣具载置A . 匣具载置台之么庙.0，用u可平行移動自如地支持該 匣具載置A 3 //己置在該台座之一側端而用以使上述 之驅動部τ旋轉連動地予以驅動旋轉 而移:接:接在該旋轉軸之端部 向給與拉力之彈性手段。賴在料軸上時向-方 ==集積化裳置之第二課題解決手段，其特 為右^物性手段係由捲帶彈簧式彈性手段所構成。 有=述簡#積化衷置之第三課題解決手段，其特 為上述驅動部係備有手動旋轉用手桿而構成。 藉由.本發明之試料集積用£具之第—課題解決手段， :將忒枓集積體和捲裝體間之相對位置關係恆常保持一 ::度而捲裳試料載體以為配置，再把試料集積體和捲裝 ::以連動驅動’從而能均一地且保持一定角度地捲裝試 料，體在_集積體上’可提升試料集積體之效率，正確 且容易地達成收納反應測定。 藉由上述試料集積龍具之第二課題解決手段，由於 -開始試料集積體就能牢固挾持試料載體之前端部，所以 捲裝在核^部時，不會發生鬆他而可保持敏密狀，.可提升 試料集積密度而有益於試料集積體之小型化，其結果也有 助於彳采針之小型化，隨之也能使測定裝置小型化，可達降 低收納反應測定相關經費之效果。 藉由上述試料集積用厘具之第三課題解決手段，由於 3)7545 12 1360509 ，。式料木積體成牢固挾持試料載體之後端部，可將長度限制 在最小需求範圍而不會有試料載體之無謂浪費，連同藉頭 ·=挾持前端側，而可以維持試料載體之捲裝之牢固性；提 问核心部表面上之試料载體之緊密性，在收納反應測定有 關作業中，可使試料載體不發生鬆弛，不但容易測定 時可提升測定精密度。 藉由上述試料集積用匣具之第四課題解決手段，而易 鲁於維持試料集積體和捲裂體間之相對位置關係，而能均— 且以一定角度捲裝試料載體至試料集積體上，容易點液在 捲裝體及容易集積試料在試料集積體上，並使作業上之产 理容易而提升作業效率，達成降低製造成本之效果。咬 藉由上述試料集積用匣具之第五課題解決手段，使試 料集積體和捲裝體在試料集積之際，得以同步旋轉，而^ 以在捲裝試料載體於試料集積體之際給與適度的張力，所 以月b獲付均一且捲裝成一定角度之效果。 藝 X ’藉由點液裝置之第—課題解決手段，祇要將嵌裝 =移動台之嵌合部分之分配材料下降至捲裝體側，就能使 4料按照預定之行列狀容易附著在捲裝於捲裝體之試料載 體上’可提升作業效率。 藉由上述點液裝置之第二課題解決手段，祇要在下降 分配材料於捲裝體側時用力，回復時可藉彈菁力量回復到 原來位置:所以可提升作業性’提高處理效率而降低成本。 又’藉由試料集積化裝置之第一課題解決手段，使試 料集積體及捲裝體得以同步旋轉，同時試料集積體可隨捲 317545 1360509 裝位置之變化向軸方向移動，而能一面給與試料載體適春 二力、-面進行捲裝，所以能密集地捲裝試料載體在試： 集積體之核心部。 藉由上述試料集積化裝置之第二課題解決手段，當 =集積體之捲裝時不需要向軸方向移動時，可藉彈善:回 復至原來位置，所以可藉簡易構成而改善作業性。 稭由上述試料集積化裝置之第三課題解決手段，可藉 =手動而進行捲裝，可用適當捲裝速度處理，而能； 應作業時之狀態。 、 【實施方式】 本發明之實施形態具體說明如下。 但是該實施形態主要係為了能充分理解本發明之主t =具體說明者，除非特別指明，否則非用以侷限本發明二 -施形態 如第1圖至第3圖所示，探針（1〇)係由吸管⑴）及具有 =隹為絲線狀之試料载體（1〇a)以螺旋狀捲裝於周面之試 :本積體(12)而構成。吸管⑴)較習知者直徑變細而整體變 支外，其基本升> 狀和習知者相同。 押缴4料集積體〇2)如第2圖至第5圖所示，較習知者直 二、’田而整體變小’同時在本體部之前端部設有可向轴方 呵私動之頭部（13)。 。式料集積體（12)之本體部係包括：形成為圓筒形，同 Τ外周面將捲褒試料载體（l〇a)用溝（12e)以螺旋狀刻設 317545 14 1360509 :=核"及將端部内嵌於核心部（12a)之基端側的把 柄部（12c)。 A .把柄部（12e)係形成有：内嵌於核心、部（12a)之前端側轴 也跟核心部（12a)之後端部一起形成〇形環溝⑽之前端 側段f部；抵接於吸管⑴）之粗徑部（lla)之内面而能定中 =及疋位，且橫剖面係形成為略多角狀並具有突出部⑴^ ^出之護手部（12d);位在中央之圓柱部；及跟形成於後端 φ部之其他軸構件（例如後述之軸構件（14))間構成連接部 (12h)而以多梯次變更外徑之軸部。 a 4手部（12d)之突出*p(12g；|和突出部（12g)之間之平面 部’具#使所吸引之氣體及液體容易流通之通路功能。 、，連接部（12h)為阻止旋轉，係切除周面上之一部分形成 平面部使其橫剖面形成冠狀’並藉由令具有相同形狀剖面 之洞孔之其他軸構件以洞孔之平坦部分對應於上述平面部 之方式而予以外嵌，從而可用不會產生相對偏移之方式傳 •遞旋轉力。 頭部（〗3)係向前端側變細而形成為前端鈍圓之圓錐 體’後端則設置可内嵌於核心部(12a)之軸部，圓錐體外側 配。在吸官（11)之粗徑部（Ua)及細徑部（Ub)之間所形成 之縮徑部（11c)之彎曲形狀，以等間距在周面上設置具有形 成曲線之外形之複數（圖中為4個）個肋部（lh、·.· Ih)。由 於該頭部（13)，由吸管（11)所吸上來的含試料之懸濁液，經 過肋部(Ua、...13a)之間S易到達試料集積體(12)之核心部 (12a) 〇 3J7545 15 1360509 又’頭部（13)藉由向近接於試料集積體（12)之核心部 (12a)之方向移動而在其與核心部（12a)之間挾持試料載體 (l〇a)之前端部。 在試料集積體（12)之核心部（12a)中，如第4圖及5圖 所不，相對於外周以螺旋狀面刻設有溝（12e)，該溝 之尺寸係設定成將試料載體（1〇a)以直徑之1/3予以埋沒， 而所殘留之2/3較核心部外表面更向外突出。溝（12e)係形 成，其傾斜角盡可能變小，同時跟鄰接之溝（12e)之間之間 距係在從核心部外周向外突出之試料載體（1〇a)互相不接 觸範圍内盡量變狹細。溝（12e)之前端連接在核心部（叫 之前端面和頭部（13)之後端面之間，使試料載體⑽)之前 端部從挾持處容易進入溝（12e)中。溝〇2e)之後端連接在設 置於核心部（12a)之後端部< 〇形環溝〇2f)，使試料載體 (10a)-旦進入該溝（12f)就由〇形環（15)強力壓住在〇科 溝⑽)之核心部側之壁面而維持張力，使被捲裝之試料载 體⑽)不會鬆弛。據此，將試料载體（1Qa)ii定在核心# ⑽)之前端及後端，被捲裝之試料載體⑽)可大㈣_ 條件下，在核心部（12狀大約整體維持均等捲裝之狀能。 做成能挾持試料載體（10a)之前端部之頭部⑽， 3圖至第5圖所示’係藉由跟核心部（i2a)同軸性嵌合之中 央，之軸射請’連接成可向轴方向自由移動，而在核 〜部(12a)之珂端部，於軸方向前方係突設有橫剖面 月形之突出部（12g)’^在頭部（13)之後端部，係配合 部〇2g)而於轴方向後方突設有形成為圓柱狀之約呈半月 317545 16 1360509 形之突出部（13c)。 m 藉由形成為上述核心部（12a)之前端部及頭部（13)之後 端部’當將頭部（13)向接近核心部（12a)之方向移動時，突 出部（〗2g、13c)係相互組合而形成具有核心部（12a)之外形 之圓柱狀，核心部（12幻及兩個突出部（12g、13勹之組合係 形成為相同直徑之圓柱狀構件，成為其前端安裝有頭部（13) 之形狀。 φ 如第5圖所示，移動頭部（13)，俾使核心部（12a)之前 端面和頭部（13)之後端面之間分離，從而可使試料載體 (1〇a)之前端部進入該分離部分，並如第4圖所示，以使核 心部（12a)之前端面和頭部（13)之後端面之間互相抵接之方 j移動，從而可藉由兩構件之間強力挾持試料載體（i〇a)之 前端部而不致於脫落。The present inventors have conducted research and development on methods and devices for determining genes, and various devices have been provided. In the above, a probe in which a plurality of samples are attached to the surface in the axial direction and formed into a rod shape is accommodated in a light-transmissive thin tube, or is formed on the surface of a sample carrier of a wire shape. The sample assembly which is attached to the rod-shaped package in a spiral shape by a plurality of samples in the longitudinal direction is accommodated in a suction tube container, and the probe is contained in the measurement and storage reaction. Since the sample for the biological component for the test and the biological component of the target are effective, the storage reaction measurement system using the probe in which the tubular container and the "type aggregate are combined has begun to be applied (refer to the patent literature). 1, 2, 3). In the storage reaction measurement method using the probe, the lower end portion of the probe is inserted into a container containing the suspension of the biological component previously labeled, and the suspension of the distantly labeled biological component is attracted to the impregnated sample. The whole of the sample carrier winding portion (hereinafter referred to as the core portion) of the aggregate is used to bond the biological component for detection attached to the sample carrier and the 317545 5 1360509 binding substance to the labeled biological component. Then, from the bottom of the probe and the lower end of the needle, the labeled biological component is suspended. The suspension 'follows' is washed and removed by the suction and removal of the cleaning liquid, and the hanging of the labeled biological component is washed off. Residual liquid of turbid liquid. After washing, the measurement liquid is sucked into the pipette, and the probe is attached to the storage reaction measuring device while the measurement liquid is held, and ultraviolet light is irradiated from the outside of the probe to make the biological component for detection and the marker organism. In the body 77, the fluorescent substance at the position where the oral substance is combined emits glory, and the photosensitive portion of the light is sensed to measure the position of the entire light emitted from the core portion, and the identified biological component is identified by the detected position. The combination of substances, and then from the combination of all identified combinations of substances. For example, in the suction tube (1) shown in the 45th ®, the sample assembly (7) is placed underneath. The core portion (2a) of the sample assembly (2) is located at the lower end of the straw portion (1) of the straw (1). It is easy to contact the cap (10) at the end from the small diameter portion (called the attraction of the night body for this purpose, and the sigh is placed at the core portion pa), and the φ Κτ is formed in the large diameter portion of the suction (1). And a small-diameter portion (the narrowed portion of the boundary 4 of (9) is formed, and is used for being externally fitted to the end portion of the device (not shown) for pressing the current collector (2) to the position, and the columnar shape The shank (2c) is formed to have a smaller diameter than the core portion (four), and is coaxially protruded from the base of the sample assembly (2). The liquid dispensing device (4) shown in Fig. 46 is placed in the pre-roll assembly. , the large-scale red (3) formed into a silk-like sample carrier (because it is too small to know - slightly, after the solution containing the sample is added in multiple places), the sample carrier to which the sample has been attached is The spiral package is attached to the core portion (2a) of 317545 6 1360509 to form the above-mentioned sample assembly (2). The skirt (4) is arranged on the movable portion (4c) at the top of each of the guide columns (4, 4, 4) by a plurality of springs (4a, ... 4a) as shown in Fig. 46, and a distribution portion (7) having a slightly square shape is installed, and a distribution (6) is provided directly under the distribution ^ (5), and a sample (3) of the flat package (3) is assembled with the sample assembly (2); And a microplate-shaped container (7) provided in the hiding device (6) and having no holes (7a, ... 7a). In the liquid dispensing device (4), the hole in the container (7) (7a, storage suspension) There is a liquid for attaching to the sample of the sample carrier's and placing the moving part (4C) with a top anti-ballistic bomb. The women's clothing has a dispensing portion (5) that can be moved (7) below each material end (_, and will stand out In the distribution part n, the touch (not shown, hereinafter referred to as the pin) is inserted into each hole and the liquid is attached to the hole, and then the lump is returned to the original position. When the thrust is raised and the upper one is equipped with 1 (5) to be able to take out the container (7), the elbow movable portion (4c) is pressed against the spring elastic force from the 11 (6), and the curling force is pressed downward. Pin, contact from above When the package is moved to the sample carrier side and the liquid adheres to the lower end of each pin, and then the movable portion (4c) is placed along the position, the package is wound up in the roll body (3) and returned to the original direction. The 4# cut body becomes the attached test 317545 7 1360509. The state of the material can be taken out. • If the sample is to be attached to the sample carrier located on the opposite side of the package (3), the sample assembly (2) After the arrangement position is set to the same position and the table is reversed, the operation is repeated in the above-described order. Accordingly, each sample is attached and fixed to the sample carrier packaged in the package (3). The package body (3) is wound around the core portion (2a) of the sample assembly (2) to form a sample assembly (2) that is stored in the state before the pipette (1).鲁—The probe (2) is taken out from the g-type (8) and stored in the straw (1) from the distal end side to form a probe for use in the measurement and storage reaction for determining the target biological component (refer to Patent Document 4). . Patent Document 1: WO02/045842 A1 Patent Document 2: W099/003341 Patent Document 3: W02/063300 A1 Patent Document 4: 曰本特愿20〇3_177228 According to the past installation [suspension system for various samples for spotting) 48-well microplate (6 rows x 8 rows) housed in Lu world standard, 96-well micro-plate (8 rows x 12 rows, 9mm pitch), 384-well microplate ("24 rows of fathers, 45mm pitch") 1536 Hole microplate (32 rows x 48 rows, 2 25mm pitch). Therefore, since the size of the container (7) is fixed, the pin is inserted into each hole (7 &, ... 73), and the liquid contained therein is attached, and then The distance between the sample carriers to which the sample is attached is determined, and the length of the sample carrier and the size of the sample assembly (2) also become larger, since the sample aggregate is determined according to the number of holes of the microplate (2) ) and the size of the straw (1) that accommodates the sample assembly (2), so the probe cannot be made small. 317545 1360509 And the 'position of the sample cannot be increased because the container (7) is fixed' Therefore, the density of the sample configuration cannot be increased. Since the size of the integrated body (2) and the suction pipe (1) cannot be achieved, for example, the amount of liquid that is immersed in the core portion (2a) of the sample assembly (2) is increased and cannot be reduced, so that it is intended to be made As the concentration is the same, the sample contained in the liquid needs to be increased. With the size of the sample assembly (2) and the pipette (1), the size of the measuring device is also increased, and the measurement cost is also increased. When the core portion (2a) of the body (2) is wound into the sample carrier in a spiral shape, the sample carrier must be uniformly wound around the core portion (2a), so that it is difficult to loosen or slide the sample carrier during the package. Therefore, the storage reaction measurement has a disadvantage of high cost in various aspects of the production apparatus, the measurement apparatus, and the material of the sample assembly (2). [Explanation] _ (Problems to be solved by the present invention) The present invention is based on the above-mentioned problems in the prior art, and the technical problem that the researcher c ▲ specifically sets to solve the problem is to provide a hair: a material, a product, a liquid device, and a sample accumulation. Chemical device, can: In the core part, the sample density is increased, and the sample size is reduced. The measurement device can be miniaturized, and the cost of the measurement and internal reaction measurement can be reduced. The solutions to the specific problems of the sample 317545 9 ^60509, the product collection device, the liquid dispensing device, and the sample accumulation device that are considered to be effective in solving the above problems are as follows. The first object solving method for collecting tools is characterized in that the sample assembly and the package are arranged such that the sample carrier is repeatedly repeated at a certain angle from the package in which the sample carrier is wound with respect to the sample assembly. The pomelo is formed at the same time as being connected to a driving skirt that causes the sample assembly and the package to be driven in synchronization with each other. The second lesson of the money (10) tool is characterized by the fact that the above-mentioned sample collection system is integrally provided with: a spiral groove is separated at a certain interval and a sample carrier is attached to the core of the groove. And a head at the front end of the core portion that is connected to the front end of the sample carrier in such a manner as to be close to each other. The third problem solving means for the above-described sample accumulating cooker is characterized in that the sample aggregate is formed by engraving two n' at the end portion of the core portion and by embedding a ^G-shaped ring groove The 〇-shaped ring holds the end portion of the above-mentioned sample carrier. (4) The method for solving the fourth problem of the above-mentioned sample-accumulation tool, wherein the sample d is included in the central portion of the body in which the sample assembly is mounted in a longitudinal direction along the shape thereof; The carrier roll on the test piece assembly is parallel to the test piece (4) wrapped on the roll, and the package body is rotatably attached to the side support portion; The pair of side support portions and the central portion of the main body of each of the side support portions are formed to form a door/history, and the sample carrier can be uniformly wound from the package to the upper 317545 1360509. In the sample assembly, the fifth problem solving means for the above-mentioned sample accumulating cooker is a sample assembly for connecting the drive shaft to the opening of the sample assembly and the center portion of the body. a side surface of the fitting portion, and an opening for connecting the drive shaft that is rotationally driven by the rotation of the upper K-stacked body to the package body is provided on a side surface of the package holding portion of the side support portion. Formed to accumulate the above samples The first object solution of the liquid dispensing device of the present invention is characterized in that: a second pedestal for mounting a package body, a two-piece erected on the base, and a body disposed on the gantry The upper guide, the upper and lower mobile stations along with the above-mentioned guide, and the detachable detachable yokes are provided on the mobile station, and the distribution member mounting table of the fitting portion can be embedded therein. The distribution member is lowered onto the package body, and the test is carried out on the package body. The test is carried out on the package body. The second problem solving means of the device is characterized in that the upper side of the wooden block and the above Between the mobile stations, the mushroom is pushed upwards, and the force of the coil spring-type elastic means, when the upper: two: = lower: by the elastic force of the magazine to keep the mobile station in the upper two. The accumulation device is characterized in that it is provided with: a sample collection tool for placing an ampoule and a rolled body in a predetermined direction, and a K-spinning machine ^ The package body can be moved to the package body by]] 317545 The formed cookware is placed on the side of the urn. The 载 载 载 庙 庙 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 The driving unit τ is driven to rotate in conjunction with the rotation: the elastic means for applying the pulling force to the end portion of the rotating shaft, and the second problem of the square-side == accumulation in the material axis The solution means that the right-hand physical means is constituted by a coil spring-type elastic means. There is a description of the third problem solving means, which is characterized in that the drive unit is provided with a manual rotation hand By the rod-type problem solving method of the present invention, the relative positional relationship between the ruthenium-concentrated body and the package body is constantly maintained at one degree: a degree and the sample carrier is considered to be Configuration, and then the sample assembly and package:: drive in a linkage so that the sample can be packaged uniformly and at a constant angle, and the body can be used to increase the efficiency of the sample assembly, and the storage can be achieved correctly and easily. Reaction determination. According to the second problem solving method of the above-mentioned sample accumulation dragon, since the sample collection body can firmly hold the front end of the sample carrier, when the package is mounted on the core portion, it does not loosen and can remain sensitive. The sample collection density can be increased to facilitate the miniaturization of the sample assembly, and as a result, the size of the needle can be reduced, and the measuring device can be miniaturized, thereby reducing the effect of the storage reaction measurement. The third problem solving means for the above-mentioned sample accumulation is based on 3) 7545 12 1360509. The wood material is firmly held at the end of the sample carrier, and the length can be limited to the minimum demand range without the unnecessary waste of the sample carrier. Together with the front end side, the sample carrier can be kept secure. The questioning of the tightness of the sample carrier on the surface of the core part allows the sample carrier to be free from slack during the storage reaction measurement, and the measurement precision can be improved not only when the measurement is easy. By the fourth problem solving means of the above-mentioned sample accumulating cookware, Yi Lu maintains the relative positional relationship between the sample aggregate and the split body, and can uniformly and package the sample carrier to the sample aggregate at a certain angle. It is easy to dispense liquid in the package and easy to accumulate the sample on the sample collection body, and it is easy to improve the operation efficiency in the operation, thereby achieving the effect of reducing the manufacturing cost. By the fifth problem solving means of the above-mentioned sample accumulating cooker, the sample aggregate and the package body are synchronously rotated while the sample is accumulated, and are supplied to the sample aggregate in the sample assembly. Moderate tension, so the monthly b is paid uniform and the effect of winding into a certain angle. Art X', by means of the first solution of the liquid dispensing device, the material of the fitting portion of the fitting = moving table can be lowered to the side of the package body, so that the four materials can be easily attached to the roll in a predetermined array. It is mounted on the sample carrier of the package to improve work efficiency. According to the second problem solving means of the above-described liquid dispensing device, as long as the force is applied to the side of the package body, the force can be restored to the original position by the force of the elastic force during the recovery: so that the workability can be improved, the processing efficiency can be improved, and the cost can be reduced. . In addition, the sample assembly and the package can be rotated synchronously by the first problem solving means of the sample accumulation device, and the sample assembly can be moved in the axial direction according to the change of the position of the roll 317545 1360509, and can be given The sample carrier is suitable for spring and spring, and can be packaged in a compact manner. Therefore, the sample carrier can be densely packed in the test: the core of the assembly. According to the second problem solving means of the sample accumulation device, when it is not necessary to move in the axial direction when the package of the assembly is assembled, it is possible to restore the workability by a simple configuration by returning to the original position. The straw is solved by the third problem of the above-mentioned sample accumulating device, and can be packaged by hand, and can be processed by an appropriate package speed, and can be operated at the time of operation. [Embodiment] Embodiments of the present invention will be specifically described below. However, this embodiment is mainly for the purpose of fully understanding the main t = specific description of the present invention, and unless otherwise specified, it is not limited to the second embodiment of the present invention as shown in Figs. 1 to 3, the probe (1) 〇) is composed of a straw (1)) and a sample carrier (1〇a) having a silk thread shape in a spiral shape on the circumferential surface: the original product (12). The straw (1) is thinner than the conventional one and becomes a whole, and its basic rise is the same as that of the conventional one. The 4th charge collection body 〇2) as shown in Fig. 2 to Fig. 5, is smaller than the conventional one, and the whole is smaller at the same time, and the front end of the main body is provided with a movable axis. Head (13). . The body portion of the aggregate (12) comprises: a cylindrical shape, and the outer peripheral surface of the same material is formed by spirally engraving the wound sample carrier (12a) with a groove (12e): 317545 14 1360509 :=nuclear " and the handle portion (12c) in which the end portion is fitted to the base end side of the core portion (12a). A. The handle portion (12e) is formed by being embedded in the core, the front end side shaft of the portion (12a) and the end portion of the core portion (12a) together with the end portion of the core portion (12a) forming the front end side portion f portion; The inner surface of the large diameter portion (lla) of the straw (1) can be centered and clamped, and the cross section is formed into a slightly polygonal shape and has a protruding portion (1) of the hand guard portion (12d); The cylindrical portion is formed, and the connecting portion (12h) is formed between the other shaft members (for example, the shaft member (14) described later) formed at the rear end φ portion, and the outer diameter of the shaft portion is changed in multiple steps. a 4 hand (12d) protrusion *p (12g; | and the flat portion between the protrusions (12g) 'has a function to make the gas and liquid that are attracted easy to flow. ·, the connection portion (12h) is To prevent rotation, one part of the peripheral surface is cut to form a flat portion so that the cross section forms a crown shape' and the other shaft members having the same shape cross section are made by the flat portion of the hole corresponding to the flat portion. Embedding, so that the rotation force can be transmitted without causing relative offset. The head (〗 3) is tapered toward the front end to form a cone with a rounded front end. The rear end is set to be embedded in the core. The shaft portion of the portion (12a) is disposed outside the cone. The curved shape of the reduced diameter portion (11c) formed between the large diameter portion (Ua) and the small diameter portion (Ub) of the suction member (11) is waited for The pitch is provided on the circumferential surface with a plurality of (four in the figure) ribs (lh, ··· Ih) which form a curved outer shape. Since the head (13) is sucked up by the straw (11) The suspension of the sample passes through the ribs (Ua, ... 13a) and easily reaches the core portion (12a) of the sample assembly (12) 〇3J7 545 15 1360509 Further, the 'head (13) holds the sample carrier (l〇a) between it and the core portion (12a) by moving in the direction of the core portion (12a) adjacent to the sample assembly (12). In the core portion (12a) of the sample assembly (12), as shown in Figs. 4 and 5, a groove (12e) is formed in a spiral surface with respect to the outer circumference, and the size of the groove is set to The sample carrier (1〇a) is buried at 1/3 of the diameter, and the remaining 2/3 protrudes more outward than the outer surface of the core portion. The groove (12e) is formed, and the inclination angle thereof is made as small as possible while The distance between the adjacent groove (12e) is as narrow as possible within the range in which the sample carriers (1〇a) protruding outward from the outer periphery of the core are not in contact with each other. The front end of the groove (12e) is connected to the core portion (called Between the front end face and the rear end face of the head (13), the front end of the sample carrier (10) is easily inserted into the groove (12e) from the holding portion. The rear end of the groove 2e) is connected to the end portion disposed at the core portion (12a) < 〇 环 〇 2f), so that the sample carrier (10a) enters the groove (12f) and is strongly pressed by the 〇 ring (15) in the 〇 沟 (10) The core portion of the side wall surface tension is maintained, so that the package carrier ⑽ the sample) does not sag. Accordingly, the sample carrier (1Qa) ii is set at the front end and the rear end of the core #(10)), and the sample carrier (10) to be packaged can be large (four) _ under the condition of the core portion (12-shaped approximately as a whole to maintain an equal volume) It is made to hold the head (10) of the front end of the sample carrier (10a), and the figure 3 to Fig. 5 is the center of the coaxial fitting with the core (i2a). Connected so as to be freely movable in the direction of the axis, and at the end of the core portion (12a), a cross-section of the moon-shaped projection (12g) is formed in the front of the axial direction. A portion (13c) having a cylindrical shape of about 317545 16 1360509 is formed in a rear portion in the axial direction behind the shaft portion 2g). m is formed by forming the front end portion of the core portion (12a) and the rear end portion of the head portion (13). When the head portion (13) is moved toward the core portion (12a), the protruding portion (〗 〖2g, 13c) The two are combined to form a cylindrical shape having a core portion (12a), and the core portion (12 phantoms and two protruding portions (the combination of 12g and 13勹 is formed into a cylindrical member of the same diameter, and the front end thereof is mounted The shape of the head (13) φ As shown in Fig. 5, the head (13) is moved so that the front end face of the core portion (12a) and the rear end face of the head portion (13) are separated, so that the sample carrier can be made ( 1〇a) The front end enters the separated portion, and as shown in Fig. 4, the side j of the front end portion of the core portion (12a) and the rear end surface of the head portion (13) are moved to each other, thereby The front end of the sample carrier (i〇a) is strongly held between the two members without falling off.

據此，試料载體（i〇a)之前端部係被挾持在核心部（12a、 之前端面及頭部（13)之後端面之間，且牢固地被固定，因 此’捲裝時容易將試料載體（1〇a)捲裝在核心部（12小 —試料載體（1〇a)乃用以附著懸濁有試料之液體並予以 f定之對象物’由可歸及鬆解之絲餘 成。其長度至少要有對應於行列之全要素之試料可== 長度’其粗細例如大约】”爪至數_左右範圍為較佳。 配，附著固定之液體之試料能有效率地分 含水;生二體本身必須具有多孔性、凹凸性、發泡性等之 分配之試Γϊΐ被覆或含浸等表面處理。上述性狀視應 Μ而Ό材料為較佳。例如以鹽酸或甲酸處理 317545 17 1360509 ，尼龍、纖維素、硝基纖維素、玻璃纖維、脫乙醯殼多糖、 根氧樹脂或單絲狀載體、繞以纖維之蠶絲、棉絲等。 夕該試料载體（1 Oa)以固定有生物學上活化之分子於其 多孔層等為較佳°該官能基係例如胺基、m基、以親核試 劑胺化者等。 。、分配於試料載體O〇a)之試料，隨試料之性質，利用乾 知法紫外父聯法、PVA交聯法、紫外交聯樹脂等固定為 較佳。According to this, the front end of the sample carrier (i〇a) is held between the core portion (12a, the front end surface, and the end surface after the head portion (13), and is firmly fixed, so that it is easy to sample the package. The carrier (1〇a) is packaged in the core portion (12 small - the sample carrier (1〇a) is used to attach the liquid in which the sample is suspended and the object to be fixed] is formed by the wire which can be attributed to the release. The sample having a length corresponding to at least the total elements of the row and column can be == length 'the thickness thereof is, for example, about 】" The range of the claw to the number _ is preferably. The sample attached to the fixed liquid can efficiently separate the water; The two bodies themselves must have surface treatment such as test coating or impregnation such as porosity, concavity, foaming, etc. The above properties are preferred depending on the composition, for example, hydrochloric acid or formic acid treatment 317545 17 1360509, nylon , cellulose, nitrocellulose, glass fiber, chitosan, root oxygen resin or monofilament carrier, silk-wound silk, cotton silk, etc. The sample carrier (1 Oa) is fixed with biological It is preferred that the activated molecule is preferably in its porous layer or the like. The functional group is, for example, an amine group, an m group, aminated by a nucleophile, or the like. The sample which is distributed to the sample carrier O〇a) is crosslinked by a dry-known UV parent-child method and PVA according to the nature of the sample. The method, the ultraviolet crosslinking resin, and the like are preferably fixed.

當將試料載體（IGa)捲裝於捲裝體（3)，並附㈣定預定 之試料懸濁液後，從捲裝體（3)換成捲裝於試料集積體⑽。 :使用之試料，例如含有核酸'多核苷酸、低核苷酸、 蛋白質糖類、免疫糸物質、激素等生物體高分子、生物 體低分子等生物體物質。又，包括附著有上述生物體物 之玻璃珠。 、 、，納於吸管⑴）前之試料集積體，如第6圖所示，並 非以單純體使用’而是以將設置於前端部之洞孔部分（未圖 不）外喪在試料集積體（12)之基部所設置之把柄部（之 連接部⑽）的方式’以同軸狀連接難具安裝用之轴構件 下文中’由於跟構件或裝置之相對性大小之關係，^ 料载體（10a)過細而無法顯示，所關中係略去試料㈣ (l〇a)而進行說明。 (10a)而使用之捲裳體 心平板狀之平板（16&) 為了附著固定試料於試料載體 (16)，如第7圖所示’係在形成為空 317545 18 1360509 中，於兩短邊側之端面（16b、16b)之中央部突出有軸構件 ‘，（16c、16c)’並在端面（16b、16b)之靠近突設有軸構件（Μ。 16c)之位置之一邊之端部，形成長方形狀之切缺部 16d) ’且上下面之兩長邊側之邊端以等間距刻設有v形 溝，在各邊所刻設之V形溝（16e、…16e)係以半間距份偏 移。 又’在平板（16a)之上下各面中，以各行平行之方式穿 籲設有從各面向空心部分貫通之細長孔（16f、…16f)多條（圖 中為16條），該等細長孔相對於軸構件（16c、16c)之中心線 具有傾斜角度。各孔（16f、…i6f)之寬度係設定為，附著液 體時藉由後述分配構件（17)之壓力施加在於孔寬方向橫跨 架設之試料载體（l〇a)之長度方向之張力，係成為附著液體 時必要之充分張力。孔（l6f、…16f)之傾斜角度乃對於試料 集積體（12)之溝（I2e)所設傾斜角大約成為垂直角度或所預 定之一定角度為理想。特別是孔（16f、…i6f)之傾斜角可由 _刻设有V形溝（I6e、…16e)之長邊側之端緣的周端部之間 之角度表示之。此情況下，孔〇6f、…16f)之傾斜角係形成 為，對於刻設於兩長邊側之端緣的V形溝（16e、…16e)上 架没之试料載體呈垂直交叉而予以配置。 捲裝體（16)之大小乃對應於後述分配構件（17)之突出 構件（17a)所配設之位置及展幅之大小，而設定平板（16a) 之大小、孔（16f、…16f)之穿設位置、γ形溝（16e、…16e) 之刻設位置等。 捲裝體（16)在形成有切缺部（ία、16d)之端面（16b、16b) 317545 xj6〇5〇9 用於卡合於旋 之切缺部形成側以及相反側之角部係刻設有 轉鎖擋的溝（16g)。 面r j外捲裝體（16)上在與形成切缺部（I6d、16d)之端 16b)大約以直角連接之端面（⑽⑽)上至少在 :近設置有切缺部（16d、】6d)之端邊之端面⑽、16h)處， 貫穿到空心部分之細長孔⑽，而預備 ㈣时透過V㈣（16e、."I6e)_設之試㈣體陶When the sample carrier (IGa) is wound up in the package (3) and the predetermined sample suspension is attached (4), the package (3) is replaced with a package (10). The sample to be used includes, for example, a biological substance such as a nucleic acid 'polynucleotide, a low nucleotide, a protein saccharide, an immunoglobulin, a hormone, or the like, or a biological low molecule. Further, it includes glass beads to which the above biological substance is attached. And the sample aggregate before the pipette (1), as shown in Fig. 6, is not used as a simple body, but is used to smother the hole portion (not shown) provided in the tip end portion (12) The manner in which the handle portion (the connecting portion (10)) is provided in the base portion is connected coaxially to the shaft member for mounting the rig. Hereinafter, due to the relative size of the member or the device, the material carrier ( 10a) It is too thin to be displayed, and the description is omitted by skipping the sample (4) (l〇a). (10a) The flat plate (16&) used for attaching the sample to the sample carrier (16), as shown in Fig. 7, is formed in the empty 317545 18 1360509, on the short side The center portion of the side end faces (16b, 16b) protrudes from the shaft member ', (16c, 16c)' and ends at one end of the end face (16b, 16b) where the shaft member (Μ. 16c) is protruded. a rectangular-shaped cutout portion 16d)' is formed, and the sides of the upper and lower sides are engraved with v-shaped grooves at equal intervals, and the V-shaped grooves (16e, ..., 16e) engraved on each side are Half-pitch offset. Further, in the upper and lower faces of the flat plate (16a), a plurality of elongated holes (16f, ..., 16f) penetrating from the respective hollow portions are provided in parallel with each row, and these are elongated. The holes have an oblique angle with respect to the center line of the shaft members (16c, 16c). The width of each of the holes (16f, ..., i6f) is set such that the tension in the longitudinal direction of the sample carrier (10a) spanned in the hole width direction is applied by the pressure of the distribution member (17), which will be described later, when the liquid is adhered. It is a sufficient tension necessary for attaching a liquid. The inclination angle of the holes (l6f, ... 16f) is ideal for the inclination angle of the groove (I2e) of the sample aggregate (12) to be a vertical angle or a predetermined angle. In particular, the inclination angle of the holes (16f, ... i6f) can be expressed by the angle between the peripheral ends of the long sides of the V-shaped grooves (I6e, ... 16e). In this case, the inclination angles of the apertures 6f, ... 16f) are formed such that the sample carriers that are placed on the V-shaped grooves (16e, ..., 16e) of the end edges of the two long sides are vertically crossed. Configuration. The size of the package body (16) is set to correspond to the position and the width of the protruding member (17a) of the distribution member (17) to be described later, and the size (16f, ..., 16f) of the flat plate (16a) is set. The position of the piercing, the position of the γ-shaped groove (16e, ..., 16e), and the like. The package body (16) is formed on the end surface (16b, 16b) of the cutout portion (ία, 16d) 317545 xj6〇5〇9 for engaging the corner portion on the side where the slit is formed and the opposite side A groove (16g) with a shift lock. The surface rj outer package (16) is provided with an end portion (16d, 6d) at least at an end surface ((10) (10)) which is connected at a right angle to the end 16b) where the cutout portion (I6d, 16d) is formed. The end faces (10) and 16h) of the end are penetrated into the elongated hole (10) of the hollow portion, and the V (four) (16e, . "I6e)_

上=者含有做為標示劑（marker)之試劑之懸濁液的點液 位置。 在捲裝體Π6)之角部以狹縫狀形成有用以掛止住試料 載體（10a)之-端部之試料載體前端部之掛止部⑽）。 為了在X捲裝此（16)上捲裝試料載體（1〇a)，係將試料 載體之前端部打結，利用掛止部⑽掛止住該打結部 分，然後按照預定捲裝.順序從v形溝（叫捲裝到另一 v 形溝（16e)而捲裝在各v形溝（16e、…16幻上。 •言亥捲體(16)之捲裝有試料載體〇〇a)的部分可由聚碳酸 酯、聚乙酸乙稀醋、聚乙烯、聚丙稀等工程用塑膠或玻璃 纖維強化塑膠等所構成。 為了使試劑懸濁液附著於捲裝於捲裝體（16)中並架設 於刻設在兩長邊側之端緣之各v形溝（16e、…16幻上之試 料載體（10a)上而使用之分配構件（27)乃如第8圖及第9圖 所示’從本體（17a)之下面垂下多數之棒狀之突出構件 (17b、...17b)’該棒狀之突出構件（m、…叫之前端部係 具備能夠保持懸濁有各種試料之少量液體之機能，本體 317545 20 1360509 (17a)上面（即設置突出構件面之相反面）係設立可用手拿的 板狀把手構件（17c)，另外，本體（17a)之側周面上形成有高 低差狀凸緣（17d)。 突出構件（17b、…17b)如第9圖所示，對於行及列之 兩方$按照預定間距平行排列，並以預定行列狀而下垂， 其各前端部形成有：向前端側開溝之v形溝、以及在其最 深處刻設更深之寬度狹小之U形溝所組合而成之組合溝 (18)，以便保持液體。 突出構件（17b)之端部，不限定於組合溝（18)，亦可為 了擴大和液體間之接觸面積而在其前端設置沿著試料載體 之溝或凹部。又，可在前端部設置如鋼筆尖之裂縫、或穿 孔、，藉略似J形狀、V形狀、U形狀等，從而提高保持 液體月匕力亦可。X，該前端部可在其前端或整體藉多孔狀、 2凸狀、發泡性等含水性材料而構成之。另外，該前端部 也可使其内部形成為筒狀、管狀、甜圈圈狀等形狀之空心。 :定之行列狀，例如配合微平板狀容器中預定之間隔 之複數孔之排列狀態，滿足以能夠插入該配置之孔的方式 出構件⑽、..，狀態，而以與微平板之世界The upper = contains the spot position of the suspension of the reagent as a marker. At the corner of the package body 6), a hook portion (10) for stopping the end portion of the sample carrier at the end of the sample carrier (10a) is formed in a slit shape. In order to package the sample carrier (1〇a) on the X-volume (16), the front end of the sample carrier is knotted, and the knotted portion is hung by the hanging portion (10), and then in accordance with the predetermined package. From the v-groove (called the package to the other v-groove (16e) and wrapped in the v-grooves (16e, ...16). • The volume of the volume (16) is loaded with the sample carrier 〇〇a The part may be composed of engineering plastic or glass fiber reinforced plastic such as polycarbonate, polyethylene acetate, polyethylene, polypropylene, etc. In order to attach the reagent suspension to the package (16) And the distribution member (27) which is placed on the sample carrier (10a) of each of the v-shaped grooves (16e, ...16) which are engraved on the end edges of the two long sides is as shown in Figs. 8 and 9. A plurality of rod-shaped projecting members (17b, ..., 17b) are suspended from the lower surface of the main body (17a). The rod-shaped projecting members (m, ..., the front end portion are provided with a variety of samples capable of remaining suspended. The function of a small amount of liquid, the upper part of the body 317545 20 1360509 (17a) (that is, the opposite side of the surface of the protruding member is provided) is a plate-shaped handle member that can be held by hand 17c), in addition, a height difference flange (17d) is formed on the side peripheral surface of the body (17a). The protruding members (17b, ..., 17b) are as shown in Fig. 9, for both rows and columns, according to the predetermined The pitches are arranged in parallel and sag in a predetermined wales, and the front end portions are formed by a combination of a v-shaped groove that is grooved toward the front end side and a U-shaped groove that is deeper and has a narrower width at the deepest portion. a groove (18) for holding the liquid. The end portion of the protruding member (17b) is not limited to the combination groove (18), and may be provided at the front end thereof along the groove or recess of the sample carrier for expanding the contact area with the liquid. Further, a crack such as a pen tip or a perforation may be provided at the front end portion, and a shape such as a J shape, a V shape, a U shape, or the like may be used to improve the liquid retention force of the liquid. X, the front end portion may be at the front end thereof. Or the whole is formed of a water-containing material such as a porous shape, a convex shape, or a foaming property. Further, the front end portion may be formed into a hollow shape such as a tubular shape, a tubular shape, or a donut shape. Shape, for example, in conjunction with a predetermined interval in a microplate container Alignment state of the hole, the hole can be inserted to meet the configuration of the member ⑽ manner, .., state, and with the world of micro-plate

::t广微平板(6行“列)、96孔微平板(8行X::t wide microplate (6 rows "columns"), 96-well microplates (8 rows of X

X4S 歹J ) ·#之排列相同者為較佳。 #再者’該分配部構件（17)中，下垂在本 大出構件（17b)之位置乃所有突出槎#n7h 原來之預定行列狀之下 件⑽、…175)在維持 以半間距之差偏向一邊，藉由 317545 21 1360509 左右反轉，可在各試料懸濁液之附著位置之中間位置處附 著該試料液。據此，較已往可縮減一半之附著間距，試料 ’ 懸濁液之附著密度也得以倍增。It is preferable that the arrangement of X4S 歹J) ·# is the same. #再者' In the distribution part member (17), the position of the main descending member (17b) is all the protrusions n#n7h, and the original predetermined determinant lower parts (10), ... 175) are maintained at a half pitch difference. On one side, by 317545 21 1360509 reverse rotation, the sample liquid can be attached to the middle of the attachment position of each sample suspension. As a result, the adhesion density of the sample 'suspension' is also doubled compared to the previously reduced adhesion pitch.

分配構件（17)之大小，係設定為相對於平板狀容器之 孔之排列狀悲而言，突出構件（17b；)之數目成為】Μ之排 列，然後，對應於分配構件(17)之突出構件〇7b)之排列位 置及其展幅度之大小，設定捲裝體（16)中之平板 小 '孔U6f、〜16f)之穿設位置、v形溝（1心、…16〇之列 設位置等，於捲裝體（16)之正面背面進行對準4次，突出 構件（17b)可將試料懸濁液附著在試料載體〇〇a)上。大 該分配構件（17)也可形成為用過即棄置者，或 可再使用者。 良 突出構件（17b)之端部材質可使用例如聚礙酸醋 酸乙烯酯、聚乙烯、聚丙烯、聚碉、聚偏二氟山烯、特敦 隆(登記商標)等塑膠、玻璃等之非金屬、或 所構成。 H屬 入 行T、/ J两防止試料縣 附著在鄰接於該端部之區域，其表面使用高分子^、 上述特㈣登記商標)或石夕等覆蓋表面而ς與疏 ,為杈佳。再者’該端部較宜形成為，在各試料之八^ 置使試料能接觸到試料载體之全周緣。 ，刀 又，分配構件（17)之本體（17a)，可成形為對 液裝置（參照第14圖及第15 、灸述 所形成之u部㈣可自由μ之; 317545 22 1360509 • 試料集積用匣具（20)如第10圖至第13圖所示，係藉 .由透明材料或半透明材料形成將試料集積體及捲裝體 G6)予以組合之匣具夾具（21)，並將匣具夾具分割成可 做為蓋套外殼之上蓋體（2Ia)及下蓋體（21b)，在除去上蓋體 )之狀痛下，將係為捲裳試料載體前之狀態下之轴構件 04)嵌裝至試料集積體（12)，以及將未捲裝有試料載體（i〇a) 之捲裝體（16)加以安裝，在此狀態下，將從捲繞有絲線之 籲捲絲管（未圖示）導出來的試料載體]〇a予以捲裝在捲裝體 (16)上。首先，將試料載體（1〇a)之前端部掛止在掛止部 (1¾) ’並捲繞於掛止部（16j)之形成側之面及相反側之面， 而繞越於最靠近地設置之v形溝（16e)上，從該v形溝（16e) 繞越到刻設在對面側之V形溝（16e)，再捲繞在相反側之面 上而繞越到最接近地刻設之V形溝（16e)，再從該V形溝 (16e)繞越到刻設於對邊側之v形溝（16e)，如此重複上述 順序，在繞越完刻設於長方向側之所有v形溝（丨6e)之後， 籲將試料載體（1 〇a)(裁斷之前）之端部位置壓下至試料集積體 (12)之核心部（12a)和頭部（13)之間，把頭部（丨3)緊接在核心 部（12a)之前端予以擠入而強力挾持試料載體（1〇a)，並將出 現在與捲裝體（1 6)為相反側之試料載體（丨〇a)之被挾持在頭 部（13)及核心部（12a)之位置的最近位置，將多餘之試料載 體（10a)予以切離，然後安裝上蓋體（21 a)而組成為試料集積 用之形態。 S具夾具（21)乃由設有可自由旋轉地嵌合試料集積體 (12)之安裝孔（2 1 c)之中央構件（21 d)、以及從該中央構件 317545 23 1360509 • (21d)之端部略向垂直方向突出之侧面支持構件（2ie、2if) -形成為門形，藉由將嵌入在捲裝體（16)之軸構件（16c、16c) ，之旋轉軸（22、22)分別予以可自由旋轉地嵌入各側面支持 構件（21e、21f)中，從而安裝成使捲裝體（16)能自由旋轉。 匣具夾具（21)在其中央構件（21d)之一端，係穿設有相 當於軸承之孔（21g)，且該孔（21g)係連通於安裝孔（21c)， 俾使試料集積體（12)及所嵌接之軸構件（14)能自由旋轉地 被肷接，而他端則穿設有用以插入夹具之孔（21 h、21 h)， 鲁並亦連通於安裝孔（21C)，其中該夾具乃用於使頭部（13)移 向抵接核心部（2 la)之方向而挾持試料載體（1〇a)之端部位 置。再者’中央構件（21d)之形成安裝孔之處之外側係形成 鎖口（23a、23b)，可提供上蓋體（2〇a)及下蓋體（2〇b)容易裝 卸之用途，以及形成位置對準用途之突起（24a)和孔（2仆）。 又，在一方之側面支持構件（21 f)上樞接有成為捲裝體 (16)之旋轉檔止之止動器（25)。該止動器（25)係形成有於中 φ央部突設有軸孔（25a)之樞接部（25b)，其一端係設置向捲裝 體（16)側大出之抵接端（25 c) ’該抵接端（25c)之内側係抵接 將該抵接端（25c)向捲裝體（16)側予以彈推之板彈菁 (25d)，他端則在板彈簧（25d)所抵接之面之相同面上突出有 當解除旋轉檔止時用以抵接於推桿之抵接端（25e)。 各側面支持構件（21 e、21 f)之外側面係穿設有孔（2丨i、 21i)，以便讓嵌入有旋轉軸（22、22)之捲裝體旋轉用夾具或 點液裝置之捲裝體旋轉軸能夠彼入，同時也穿設有孔 (2lj、2lj) ’以便讓抵接於止動器（25)之抵接端（25c)以解除 317545 24 1360509 旋轉擋止用工具或點液裝置的銷針能夠插入。 在侧面支持構件（21e、21f)之下蓋體（21b)側之前端， 突設有卡合用孔側突出構件（26)，該卡合用孔側突出構件 係於橫向穿設有下側之側面及内側之端面呈開口狀之軸孔 (26a)，在側面支持構件（21e、21f)之上蓋體（21a)側之前端， 突設有卡合用轴側突出構件（27)，該卡合用軸側突出構件 (27)並於橫向突設有卡合於下蓋體（21b)側之卡合用孔側突 出構件（26)的軸（27a)。 上蓋體（21a)中，在内面側向止動器方向突出有嵌入於 止動器（25)之轴孔（25a)的軸（28)，在軸之突出位置之外側 面，突設有按壓構件（29, 29)，則更從外側面按壓下蓋體 (21b)而確保上下兩蓋體（21a、21b)之位置。The size of the distribution member (17) is set to be relative to the arrangement of the holes of the flat container, and the number of the protruding members (17b;) becomes an arrangement of Μ, and then corresponds to the protrusion of the distribution member (17). The arrangement position of the member 〇 7b) and the magnitude of its spread width, the setting position of the small flat holes 'holes U6f, 〜16f in the package body (16), and the v-shaped groove (1 heart, ... 16 〇) The position or the like is aligned four times on the front and back surfaces of the package body (16), and the protruding member (17b) can adhere the sample suspension to the sample carrier 〇〇a). The distribution member (17) can also be formed as a disposable or reusable user. The end material of the good protruding member (17b) may be, for example, a non-metal such as a plastic such as polyvinyl acetate, polyethylene, polypropylene, polyfluorene, polyvinylidene diene, teton (registered trademark), or the like. Or constitute it. H is a T- or /J-preventing sample county attached to the area adjacent to the end, and the surface is covered with a polymer ^, the above-mentioned special (4) registered trademark) or Shi Xi, etc. Further, the end portion is preferably formed so that the sample can be brought into contact with the entire periphery of the sample carrier at each of the samples. The knives and the body (17a) of the distribution member (17) can be formed into a liquid-aligning device (refer to Figs. 14 and 15 and the u-part (4) formed by the moxibustion can be freely μ; 317545 22 1360509 • Sample collection The cooker (20) is a cooker jig (21) which combines a sample aggregate and a package G6) by a transparent material or a translucent material, as shown in Figs. 10 to 13 and The fixture is divided into a cover member (2Ia) and a lower cover (21b), and under the pain of removing the upper cover, the shaft member is in a state before the carrier of the sample is taken. The cartridge (12) is fitted to the sample, and the package (16) to which the sample carrier (i〇a) is not wound is mounted. In this state, the coiled wire tube from which the wire is wound ( The sample carrier that has been exported (not shown) is packaged on the package (16). First, the front end of the sample carrier (1〇a) is hung on the hanging portion (13⁄4)' and wound on the side of the forming side of the hanging portion (16j) and the opposite side, and the winding is closer to the nearest side. The V-shaped groove (16e) provided on the ground is wound from the v-shaped groove (16e) to the V-shaped groove (16e) engraved on the opposite side, and wound on the opposite side to be wound up to the nearest side The V-shaped groove (16e) is engraved, and then wound from the V-shaped groove (16e) to the V-shaped groove (16e) engraved on the opposite side, so that the above sequence is repeated, and the winding is completed in the long After all the v-grooves (丨6e) on the direction side, the end position of the sample carrier (1 〇a) (before cutting) is pressed down to the core portion (12a) and the head portion of the sample assembly (12). Between the head (丨3), the front end of the core portion (12a) is squeezed in to firmly hold the sample carrier (1〇a), and will appear on the opposite side to the package body (16). The sample carrier (丨〇a) is held at the closest position of the head (13) and the core portion (12a), and the excess sample carrier (10a) is cut away, and then the upper cover body (21a) is attached. The composition is the shape of the sample accumulation . The S-clamp (21) is provided with a central member (21d) provided with a mounting hole (2 1 c) for rotatably fitting the sample assembly (12), and from the central member 317545 23 1360509 • (21d) The side support members (2ie, 2if) which protrude slightly in the vertical direction are formed in a gate shape by the shaft members (16c, 16c) to be embedded in the package body (16), and the rotation shafts (22, 22) Each of the side support members (21e, 21f) is rotatably inserted into the side support members, so that the package body (16) can be freely rotated. The cooker jig (21) is provided with a hole (21g) corresponding to the bearing at one end of the central member (21d), and the hole (21g) is connected to the mounting hole (21c) to make the sample assembly ( 12) and the engaged shaft member (14) can be spliced freely, while the other end is provided with a hole for inserting the clamp (21 h, 21 h), and the connection is also connected to the mounting hole (21C) Wherein the jig is used to move the head (13) toward the end of the core portion (2 la) while holding the end position of the sample carrier (1〇a). Further, the central member (21d) is formed with a lock port (23a, 23b) on the outer side of the mounting hole, and the upper cover body (2〇a) and the lower cover body (2〇b) can be easily attached and detached, and A protrusion (24a) and a hole (2 servant) for positional alignment are formed. Further, a stopper (25) that is a rotation stop of the package body (16) is pivotally connected to one of the side support members (21f). The stopper (25) is formed with a pivot portion (25b) in which a shaft hole (25a) is protruded from a central portion of the middle portion, and one end thereof is provided with an abutting end which is larger toward the side of the package body (16) ( 25 c) 'The inner side of the abutting end (25c) abuts the plate spring (25d) which pushes the abutting end (25c) toward the side of the package body (16), and the other end is in the leaf spring ( 25d) The same surface of the abutting surface protrudes from the abutting end (25e) for abutting the push rod when the rotation stop is released. Holes (2丨i, 21i) are formed on the outer side surfaces of the side support members (21e, 21f) so that the package rotating the jig or the liquid dispensing device is embedded in the rotating shaft (22, 22) The rotating shaft of the package body can be inserted into the hole, and holes (2lj, 2lj) are also worn to abut the abutting end (25c) of the stopper (25) to release the 317545 24 1360509 rotating stop tool or The pin of the liquid dispensing device can be inserted. At the front end of the side cover member (21e, 21f) on the side of the lid body (21b), a engaging hole side projecting member (26) is protruded, and the engaging hole side projecting member is attached to the side of the lower side of the lateral side. And a shaft hole (26a) having an open end surface, and a front end side of the side support member (21e, 21f) on the side of the lid body (21a), and a shaft side protruding member (27) for engaging is protruded. The side protruding member (27) has a shaft (27a) that engages with the engaging hole side protruding member (26) on the lower cover body (21b) side in the lateral direction. In the upper cover body (21a), a shaft (28) that is fitted into the shaft hole (25a) of the stopper (25) protrudes in the direction of the stopper on the inner surface side, and a pressing portion is protruded from the outer side of the protruding position of the shaft. In the members (29, 29), the lower cover (21b) is pressed from the outer side to secure the positions of the upper and lower covers (21a, 21b).

、於E具夾具⑼中組襄了安裝捲裝試料載體（i〇a)前之 试料集積體（12)及已捲裝試料載體（叫之捲裝體⑽而構 成之E具（20)中’如第13圖所示’以令試料集積體⑴)之 軸心及捲裝體（16)之細長孔⑽、...16f)約平行之方式，並 以令其具有配合於捲裝試料集積體（12)之用以捲裝試 體0叫的溝⑽)之傾斜角的傾斜角而予以安裝，而穿設各 側面支持構件（21e、2lf)之旋轉樞接孔（3G，3〇)。 用於將試料懸濁液以預定行列狀附著於捲裝於設置在 匣具（20)之捲裝體（16)之試料載俨 係如第14圖所示，由上之點液1置⑽） (41)、從長邊侧之一邊之中央 十板狀口座 該架台⑷)可以上下移動之移^^設的架台叫對於 矛夕動〇 (43)、以及作用有彈推力 317545 25 丄則⑽ 丄則⑽In the E-clamp (9), the sample assembly (12) before the package sample carrier (i〇a) and the packaged sample carrier (called the package (10) are used to form the E-piece (20). The 'as shown in Fig. 13' is such that the axis of the sample assembly (1) and the elongated holes (10), ... 16f) of the package (16) are approximately parallel, so as to have a fit to the package The sample assembly (12) is mounted for mounting the inclination angle of the inclination angle of the groove (10) of the sample body 0, and the rotation pivot hole (3G, 3) of each of the side support members (21e, 2lf) is worn. 〇). The sample suspension for attaching the sample suspension to the package (16) provided in the cookware (20) in a predetermined wales is as shown in Fig. 14, and the liquid 1 is placed on the top (10). (41), from the center of the long side, the ten-plate-shaped mouth seat, the gantry (4)) can be moved up and down, and the gantry is called for the spurs (43) and the elastic thrust 317545 25 丄(10) 丄 (10)

料在以（4取上部位置之彈普 (41 b、二:(4 :具:置部(41 a: m 構件 ®具大小並刻設有猶為向下= ,:::1)乃上面配合 Γ定位構件⑽、41b)乃設置成包㈣載The material is in the upper part of the position (41 b, two: (4: with: the part (41 a: m member ® size and engraved with the downward =, ::: 1) is above The Γ positioning members (10), 41b) are set to pack (4)

芙:自Γ方向之一邊；該止動器㈣乃在架台(4取 基。Μ台座⑷)直立者，而用於限制下降位置。 该定位構件（41b、41b)在其相對面係形成傾斜面，可 提供昆具及微平板狀容器#必要構件容㈣置在預定位置 之導向用途。 架台（42)如第14圖及第15圖所示，在架台本體㈣) 之面向台座（41)侧設置有導執（42b)，用以在移動台（43)於 上下方向滑動時將移動方向導引成直線狀。然後，架台本 體（42a)之側面係固定有設置於移動台（43)之彈簧襞置〇4) 之彈簧捲片（44a)之前端部，當移動台下降而彈簧捲片（44a) 伸長時，被伸長之彈簧捲片（44a)要恢復原狀捲繞時所產生 之彈簧力係產生作用而使移動台（43)上升而復歸至原來位 置。 ' 移動台（43)具備有可自由滑動地嵌入導執（42b)之移動 台本體（43a)、在移動台本體（43a)之背面側設置成可自由旋 轉之彈簧捲片（44a)捲繞用之捲線筒（44b)、以及於移動台本 體（43a)之下端之正面側將平面形狀為門形之構件向水平 方向突出而成之分配構件載置台（43b)。 317545 26 1360509 • 該分配構件載置台（4补）係形成為，其門形之中央空間 部分係為具有用做為供分配材料（17)從上方嵌入之嵌入部 (43c)的必要大小及形狀之孔部。 架台（42)如第15圖所示’係將匠具⑽放置於匠具載 置部（41a)，並於分配構件載置台（43b)之敌入部（43〇嵌入 在其突出部（17b、...17b)之前端部保持試料懸濁液之分配 構1牛（17) ’且降低移動台（43)到抵接止動器（4ic)為止從 鲁而能在捲裝在安裝於g具之捲裳體（16)中之試料載體⑽) 上，按照預定行列狀附著試料懸濁液。然後，藉由彈菩捲 片（44a)之彈簧作用使移動台（43)上昇後，取出分配構件 (17)，再將保持有新試料懸濁液之分配材料（17)左右反轉後 予以肷入，再次藉由將移動台（43)降低到抵接止動器（Me) 為止，彳文而此夠對於在試料載體上按照預定行列狀附著有 試料懸濁液之試料載體（1〇a)，在各試料懸濁液之附著位置 之中間處，重新追加附著新的試料懸濁液。 鲁然後，使移動台（43)上升而取出分配構件（丨7)，將安裝 在ϋ具（20)之捲裝體（16)反轉，並重新設定在度具載置部 (4 1 a) ’依照上述順序操作而以預定行列狀附著試料懸濁 液，再使分配構件（17)左右相反而進行操作，而追加附著 新的試料懸濁液於附著有各試料懸濁液之位置之中間位 置，而提兩試料载體（10a)之試料懸濁液之附著密度。 试料集積化裝置（50)之構成如第16圖及第17圖所 不，包括.於兩側部分直立設置側壁（51a、51b)，而形成 凹狀之正面形狀之底座（51);安裝在右側側壁（5lb)，可使 317545 27 1360509Fu: one side of the direction of the squat; the stopper (4) is used to limit the lowering position in the erecting frame of the pedestal (4 pedestal pedestal (4)). The positioning members (41b, 41b) form an inclined surface on the opposite side thereof, and can provide a guide for the use of the essential member and the micro-flat container (4) at a predetermined position. The gantry (42) is provided with a guide (42b) on the pedestal (41) side of the gantry body (4) as shown in Figs. 14 and 15 for moving when the mobile station (43) slides up and down. The direction is guided in a straight line. Then, the side of the pedestal body (42a) is fixed to the front end of the spring winding piece (44a) provided on the spring 〇4) of the moving table (43), and when the moving table is lowered and the spring winding piece (44a) is extended The spring force generated by the elongated spring coil (44a) to be restored to the original winding is caused to cause the moving table (43) to rise and return to the original position. The mobile station (43) is provided with a moving table main body (43a) that is slidably inserted into the guide (42b), and is rotatably spring-wound (44a) on the back side of the moving table main body (43a). A spool (44b) and a distribution member mounting table (43b) which protrudes in a horizontal direction from a member having a gate shape in a planar shape on the front side of the lower end of the movable table main body (43a). 317545 26 1360509 • The distribution member mounting table (4 complement) is formed such that the central space portion of the gate shape has the necessary size and shape as the embedding portion (43c) embedded from above for the distribution material (17) The hole. As shown in Fig. 15, the gantry (42) is placed on the craftsman's mounting portion (41a) and is placed on the projection portion (43b) of the distribution member mounting table (43b). ...17b) The front end maintains the distribution of the sample suspension 1 cattle (17) 'and lowers the moving table (43) to the abutting stopper (4ic) from Lu and can be mounted on the package On the sample carrier (10) in the roll body (16), the sample suspension was attached in a predetermined matrix. Then, the moving table (43) is raised by the spring action of the elastic bobbin piece (44a), the dispensing member (17) is taken out, and the dispensing material (17) holding the new sample suspension is reversed left and right. Intrusion, again by lowering the mobile station (43) to the abutment stopper (Me), it is sufficient for the sample carrier to which the sample suspension is attached to the sample carrier in a predetermined matrix. a) A new sample suspension is newly added to the middle of the attachment position of each sample suspension. Lu then raises the mobile station (43) to take out the distribution member (丨7), reverses the package (16) mounted on the cookware (20), and resets it to the fixture mounting portion (4 1 a). 'In accordance with the above procedure, the sample suspension is attached in a predetermined wales, and the distribution member (17) is operated in the opposite direction, and a new sample suspension is additionally attached to the position where the sample suspension is adhered. In the intermediate position, the adhesion density of the sample suspension of the two sample carriers (10a) was raised. The sample accumulation device (50) is constructed as shown in Figs. 16 and 17 and includes a side wall (51a, 51b) erected on both side portions to form a concave front surface (51); On the right side wall (5lb), you can make 317545 27 1360509

言^集積_)及捲裝體（16)連動而旋轉，同時可向轴方向 集積體(12)之驅動部(52);當試料集積 方向㈣時賦予彈推力而使直線移動容易之彈箬裝置 ⑼，以傾斜狀載置匿具（2〇)並從側壁（5ia、叫之一方$ 他方側進行直線移動之£具載置台（54);將職具載p 二)可直線移動地予以支持之直動轴承型支持台(55);以： 汉在底座⑻之正面左側之側壁（5la)，當安裝^具㈣或 將E具（20)予以卸下時，防止g具载置台（54)往抽方向移動 而擋止載置台用之載置台掛止構件（56)。 側壁（51b)之内側，在匣具載置台（54)之中央部之上 方’係設置有肖水平方向突出之E具安裝用銷針（5u)，而 側壁(51b)之外面側’係藉複數之棒狀構件從側壁外面離開 一定距離設置驅動部用之蓋體（52a)，在側壁（51b)和蓋體 (52a)之間設置驅動部（52)。 驅動部（52)之構成係包括：旋轉軸（52b)，以可於軸方 鲁向移動之方式形成，並具有用以卡合於安裝於匣具（2〇)之 試料集積體（12)之頭部（13)的前端部；導向軸（52c)，當將 已完成軸方向之移動的旋轉軸予以復歸至原位置時，用於 對抗旋轉擋止及彈推力而往復歸方向予以拉回；連結構件 (52d)，將旋轉軸（52b)&導向軸（52c)在突出於蓋體（52a)之 外面之端部予以連結；拉回用把手（52e)，用於同時將設置 於連結構件（52d)之外面側之旋轉軸（52b)及導向軸（52c)予 以拉回；軸側齒輪構件（52f)，由用於賦與旋轉軸（5 2b)旋轉 力、同時支持軸方向之移動的軸承所構成；附單向離合器 28 317545 l36〇5〇9 2動側齒輪構件(52g)’藉手動給予旋轉力同時傳 =到旋轉軸⑽），·以及中間商輪構件（52h)，以可連動之方 二連結軸側齒輪構件（52f)及驅動側齒輪構件（52g)。 在旋轉軸（52b)中，在周面上以圓周上等分之方式刻設 兩條和中心軸平行之溝（52i)，而用於將軸側齒輪構件⑽ ^疋轉力轉換成為旋轉軸（52b)之前進力之銷針（未圖示）係 此轴側齒輪構件（52f)之内周面向中心側突出，同時銷針之 則端部係形成具有可移動自如地往軸向插入溝(52”之長 度及粗細。 又，在驅動側齒輪構件（52g)中，在突出於蓋體（5h) 夕側之軸端部係外嵌有手動用把手（57)，隨著轉動該把手 (57)之手指之動作而旋轉驅動側齒輪構件 動側齒輪構件(.52g)介由Μ錄構件（52h)㈣旋轉力^ 軸側齒輪構件（52f)，再經軸側齒輪構件（52f)傳達驅動力到 旋轉軸（52b)。 另外，也可以直接將馬達（未圖示）連結在驅動側齒輪 構件（52g)上來替代上述把手（57)，形成利用馬達旋轉驅動 之驅動部（52)。 匣具載置台（54)上面，在左側位置之側端部之中央部 之螭緣係大设有樞接構件（54a)，其係將前端部插入至設置 於側面支持構件（21e)之孔（21j)中而予以支持，在左側下端 之角部並突設有可防止匣具（20)滑落之定位構件（54b)。 又，側面支持構件（2If)之右側下端之角部係突設有可 防止匣具（20)滑落之定位構件（54c)。 3J7545 29 :.之掛側端部時’若將g具載置台（54)移向接近側壁⑽） .之f ^ ’令解除掛止構件（59c)將該鎖固構件（59b)之非掛止 4端。p按璧至解除掛止側’而解除掛止構件（別)和鎖固構 =(59C)之間的連結時，則會藉彈簧捲片（53c)之彈推力，在 … 匕$置（58C)之抗力下，將導向轴（52c)朝向接近側壁 (5 1 a)之方向移動。 ^為了將旋轉軸（52b)之前端部卡合於試料集積體（12) 鲁之頭邛（13)，而將拉回用把手（52e)拉向蓋體（52y之外面， ^具（20)可安裝在試料集積化裝置（5〇)時，检鎖機構部# 9)起作用而卡止成不會回到原位置，而當安錢具後， ” “ *卜止而藉彈百捲片（53c)之彈簧彈推力將旋轉軸 月向側壁（51b)之内面移動時，阻尼裝置⑽)係對導向軸 (52c)賦予適當之抵抗力，以便控制移動速度，俾使其不合 急遽地移動。 曰 該試料集積化裝置（5〇)中’係將匠具（2〇)載置於匡具載 • = 口⑽’並將樞接構件⑽)之前端部插入£具（2〇)之孔 ω而μ支持，同時#定位構件（防 ::圖)’再操作載置㈣止構件(56)之抓柄部分以解(除： :具載置台(54)之掛止用突起間之掛止狀態，使g具 置台（54)可向侧壁（51b)側移動，從而㈣具載置台⑼ =妾近正面右側之側壁（51b)之方向移動，當銷針⑴e)移動 =插入孔⑵j)時（參照第18圖），解除栓鎖機構部（59)的卡 &固定，同時銷針（51e)會按壓£具夾具（21)之止動 之抵接端（25e)，而令與捲裂體〇6)卡合之抵接端（25c)移向 317545 1360509 解除卡合側，而解除止動器（25)和捲裝體⑽間之卡入，從 -而將捲裝即6)設為相對於g具爽具（21)以轴構件（^、 * 16c)為中心之自由旋轉狀態。 紐’將旋轉軸（52b)朝向接近試料集積體（12)之方向 移動，將前端部卡合在頭部（13)，使旋轉力能傳達到試料 集積體（12)。 當捲裝體（16)成為自由狀態後，若旋轉連結在驅動側 齒輪構件（52)之把手（57)時，則驅動側嵩輪構件（5如會旋 轉’亚由驅動侧齒輪構件（52g)透過中間齒輪構件p汕)轉動籲 軸側齒輪構件（52f)。如此藉由轉動各齒輪，使卡合在旋轉 軸（52b)之前端部之頭部〇3)和試料集積體（12)一起旋轉·" 而從捲裝體（16)捲取試料載體（]〇a)，且由於检鎖機構部州 已解除卡合固定’故可藉由彈簧捲片（53e)之彈簧彈推力而 令旋轉轴（52b)及導向軸（52c)慢慢移向側壁（51a)側，而依 隨形成在試料集積體（12)上之溝（12e)以螺旋狀捲繞試料載 體（10a)。 捲裝試料載體（l〇a)於試料集積體（12)之後，從厘具（，籲 取下安裝有軸構件（14)之狀態之試料集積體（12)，並使用紫 外光照射裝置照射紫外光於捲裝在試料集積體之試料 載體（10a) ’而固定附著在試料載體（1〇a)之試料。 、一般所使用之紫外光照射裝置，由於係使用由右到左 或由上往下單向照射之裝置，所以必須有能夠在紫外光照 射裝置内均一地照射試料集積體（12)之全周用之裝置。 以下’說明能照射試料集積體（]2)之全周用紫外光照 317545 32 1360509 射裝置 _试料集積體旋㈣置⑽）乃如第2Q圖至第22圖所 :形成為將試料集積體（12)橫排成—列之多連裝型（圖 =6連裝者），而為可繞著轴使各試料集積體 轉 之裝置。 在裝置正面’具有用以嵌人轴構件（14)之自由端側之 連、.，。孔（6la)之旋轉軸（61、...61)係露出在框體㈣之前 修面’而分別同軸地安裝在各個旋轉軸（61、…61)之齒輪 ( 62)係以互相咬合而同步旋轉之方式組合在框體籲 (6〇a)内側’亚具有：咬合於一個齒輪（62)而旋轉驅動各齒 輪（62、...62)之馬達直接連接型之驅動齒輪（63)、做為將電 ^供，於直接連接於驅動齒輪（63)之馬達（64)的電源且組 一預疋個數之乾電池（65)、以及將按紐（66a)之前端部突出 在裝置正面之開關（66)，並將該開關（66)和乾電池及馬 達（64)之間以未圖示之電線連結，當按壓開關（66)使電源導 #通時，藉由從乾電池（65)供給之電力使馬達（64)轉動，再透 過驅動齒輪（63)使各齒輪（62、…62)旋轉。 如第22圖所示，旋轉軸（61、...61)之各連結孔（61 a、… 61a)中係内插有連結於各試料集積體（12、... 12)之軸構件 (14、…：^)，並藉由按壓按鈕（66a)而使馬達（64)通電起動， 從而轉動旋轉軸（61、".61)。確認開始轉動後，將試料集 積體旋轉裝置（6〇)放入紫外光照射裝置（未圖示）中，各試料 集積體（12、…12)係隨旋轉軸（61、”.61)之旋轉而轉動，使 紫外光均一照射在各試料集積體（丨2、…12)之全周。所以 33 317545 1360509 藉使用試料集積體旋轉裝置（60)，在紫外央昭The sound accumulation product _) and the package body (16) are rotated in conjunction with each other, and can be driven to the drive unit (52) of the axial direction (12); when the sample is accumulated in the direction (4), the elastic force is given to facilitate the movement of the straight line. The device (9) mounts the concealer (2〇) in an inclined shape and is linearly movable from the side wall (5ia, the one side of which is a side of the side of the side of the side (54); Supported direct-acting bearing type support table (55); to: Han on the side (5la) of the front left side of the base (8), when installing the tool (4) or removing the E-tool (20), prevent the g-mounted table ( 54) The mounting table hanging member (56) for stopping the mounting table is moved in the drawing direction. On the inner side of the side wall (51b), above the center portion of the cooker mounting table (54), an E-mounting pin (5u) protruding in the horizontal direction is provided, and the outer side of the side wall (51b) is borrowed. The plurality of rod-shaped members are provided with a cover (52a) for driving the drive from a distance from the outside of the side wall, and a drive portion (52) is provided between the side wall (51b) and the cover (52a). The driving portion (52) is configured to include a rotating shaft (52b) formed to be rotatable in the axial direction and having a sample assembly (12) for being engaged with the cooker (2). a front end portion of the head portion (13); and a guide shaft (52c) for retracting the reciprocating direction against the rotation stop and the spring force when the rotation shaft that has completed the movement of the axis direction is returned to the original position a connecting member (52d) for connecting the rotating shaft (52b) & guide shaft (52c) at an end protruding from the outer surface of the cover body (52a); and pulling back the handle (52e) for simultaneously setting The rotating shaft (52b) and the guide shaft (52c) on the outer surface side of the connecting member (52d) are pulled back; the shaft side gear member (52f) is used to impart a rotational force to the rotating shaft (52b) while supporting the axial direction. The moving bearing is composed of a one-way clutch 28 317545 l36〇5〇9 2 moving side gear member (52g) 'by manual imparting rotational force to transmit to the rotating shaft (10)), and intermediate commercial wheel member (52h) The shaft side gear member (52f) and the driving side gear member (52g) are coupled to each other in a movable manner. In the rotating shaft (52b), two grooves (52i) parallel to the central axis are circumferentially equally divided on the circumferential surface, and the shaft side gear member (10) is converted into a rotating shaft. (52b) The pin of the previous force (not shown) is such that the inner circumference of the shaft side gear member (52f) protrudes toward the center side, and the end portion of the pin is formed to be movably inserted into the groove axially. Further, in the drive side gear member (52g), a manual handle (57) is externally fitted to the shaft end portion protruding from the side of the cover body (5h), and the handle is rotated with the handle (57) The action of the finger rotates to drive the side gear member moving side gear member (.52g) via the recording member (52h) (4) rotational force ^ shaft side gear member (52f), and then through the shaft side gear member (52f) The driving force is transmitted to the rotating shaft (52b). Alternatively, a motor (not shown) may be directly coupled to the driving side gear member (52g) instead of the above-described handle (57), and a driving portion (52) that is rotationally driven by the motor may be formed. On the top of the cooker mounting table (54), the rim of the center of the side end of the left side position The pivoting member (54a) is provided to be inserted into the hole (21j) provided in the side support member (21e) for support, and the cookware is prevented from protruding at the corner of the left lower end ( 20) The locating member (54b) that has been slid down. Further, the corner portion of the right lower end of the side support member (2If) is provided with a positioning member (54c) that prevents the cooker (20) from slipping. 3J7545 29:. At the end, 'if the g-mounting table (54) is moved closer to the side wall (10)), the f ^ ' is to release the hanging member (59c) to unhook the end of the locking member (59b). p Press 璧When the connection between the hanging member (other) and the locking structure = (59C) is released to the side of the lifting side, the spring force of the spring winding piece (53c) is used, and the setting is made by the spring (53C). Under the resistance, the guide shaft (52c) is moved toward the side wall (5 1 a). ^ In order to engage the front end of the rotating shaft (52b) with the sample assembly (12) Luzhitou (13), Pulling the pull-back handle (52e) toward the cover (the outer surface of 52y, when the tool (20) can be mounted on the sample accumulation device (5〇), the lock mechanism unit #9) acts and locks up return When the vehicle is in the original position, and the tamper is used, the damper device (10) is guided by the spring-loading force of the slinger (53c) when the rotating shaft is moved to the inner side of the side wall (51b). The shaft (52c) is given appropriate resistance to control the moving speed so that it does not move in an imminent manner. 曰In the sample accumulation device (5〇), the craftsman (2〇) is placed on the cookware. = mouth (10)' and insert the front end of the pivoting member (10) into the hole ω of the (2〇) and μ support, while the #positioning member (anti-:: figure) 're-operate the mounting (four) stop member (56) The grip portion is solved (except: the hanging state between the hanging protrusions of the mounting table (54), so that the g-mounting table (54) can be moved toward the side wall (51b) side, thereby (4) having the mounting table (9) = When the pin (1)e) moves = insert hole (2) j) (refer to Fig. 18), the card & 51e) will press the abutting end (25e) of the retaining clamp (21), and the abutting end (25c) engaged with the splitting body )6) will be moved to the 317545 1360509 to release the engaging side And the engagement between the release stopper (25) and the package body (10) is set to be the center of the shaft member (^, *16c) with respect to the g-supplement (21). Free rotation. The button "u" moves the rotating shaft (52b) toward the sample assembly (12), and engages the tip end portion with the head portion (13) to transmit the rotational force to the sample assembly (12). When the package body (16) is in a free state, if it is rotatably coupled to the handle (57) of the drive side gear member (52), the drive side wheel member (5 if rotated) is driven by the drive side gear member (52g) The crank shaft side gear member (52f) is rotated through the intermediate gear member p汕). Thus, by rotating the gears, the head 〇 3) engaged with the end portion of the rotating shaft (52b) and the sample assembly (12) are rotated together, and the sample carrier is taken up from the package body (16) ( ]〇a), and since the state of the lock mechanism is released, the rotation shaft (52b) and the guide shaft (52c) can be slowly moved to the side wall by the spring force of the spring coil (53e). On the side of (51a), the sample carrier (10a) is spirally wound in accordance with the groove (12e) formed on the sample assembly (12). After the sample carrier (10a) is wrapped in the sample assembly (12), the sample assembly (12) in a state in which the shaft member (14) is attached is taken out from the PCT, and irradiated with an ultraviolet light irradiation device. Ultraviolet light is attached to the sample carrier (10a) of the sample assembly and fixed to the sample carrier (1〇a). The ultraviolet light irradiation device generally used is from right to left or from the top. Since the device is irradiated in one direction, it is necessary to have a device capable of uniformly irradiating the sample assembly (12) in the ultraviolet light irradiation device. The following description of the entire week for irradiating the sample assembly (2) Ultraviolet light 317545 32 1360509 Shooting device _ sample accumulator body (4) set (10) is as shown in Fig. 2Q to Fig. 22: formed to arrange the sample assembly (12) horizontally into a multi-package type (Fig. 6-packer), which is a device that can transfer each sample assembly around the axis. The front side of the device has a connection for engaging the free end side of the shaft member (14). The rotating shafts (61, ... 61) of the holes (6la) are exposed before the frame (four), and the gears (62) coaxially mounted on the respective rotating shafts (61, ... 61) are engaged with each other. The synchronous rotation is combined on the inner side of the frame body (6〇a) to have a motor direct connection type drive gear (63) that is engaged with a gear (62) and rotationally drives each gear (62, ... 62). , as a power supply to the motor (64) directly connected to the drive gear (63) and grouping a predetermined number of dry batteries (65), and protruding the front end of the button (66a) to the device a switch (66) on the front side, and the switch (66) and the dry battery and the motor (64) are connected by a wire (not shown), and when the switch (66) is pressed to turn on the power source, by the dry battery (65) The supplied electric power rotates the motor (64), and the respective gears (62, ... 62) are rotated by the drive gear (63). As shown in Fig. 22, shaft members connected to the respective sample assemblies (12, ... 12) are interposed in the respective coupling holes (61 a, ... 61a) of the rotary shafts (61, ... 61). (14, ...: ^), and the motor (64) is energized to start by pressing the button (66a), thereby rotating the rotating shaft (61, ".61). After confirming the start of rotation, the sample assembly rotating device (6 〇) is placed in an ultraviolet light irradiation device (not shown), and each sample assembly (12, ... 12) is associated with the rotation axis (61, ".61). Rotate and rotate to uniformly illuminate the entire circumference of each sample assembly (丨2, ...12). Therefore, 33 317545 1360509 uses the sample assembly rotating device (60) in the ultraviolet

並使用未圖示之試料集積體安裝架， 納於吸管（11)中。 在紫外央昭射裝置内可 周之紫外光照射，充分 -斌料加以固 14) ’如第1圖所示， 將試料集積體（12)收 試料集積體之製造及蚀@ 關於試料集積體（12)之製造及其使用方法，當使用第 一實施形態之試料載體（10a)、軸構件（14)、捲裝 分配構件（17)、£具（20)、點液裝置（4〇)、試料集積化裝置 (50)、試料集積體旋轉裝置（6〇)等時，係如下所示。 在試料集積心具⑽之^具夹具（21)巾安裝試料集 積體（12)及捲裝體（16)，首先在#TIf &夹具⑵）之上蓋體 (21a)之狀態.下，安裝嵌人有軸構件（14)且為捲裝試料載體 U〇a)則之試料集積體（12)、及未捲裝試料載體〇叫之捲裝 體（16)，然後在安裝有試料集積體（12)及捲裝體⑽之狀態 下，將從捲繞有線材之捲線筒反覆拉出之試料載體（i〇a)捲 裝在捲裝體（16)。 捲裝時，將試料載體（1〇a)之前端部卡合固定於掛止部 (16j)，再旋轉捲裝體（]6)而予以捲繞至掛止部（】句）之形成 側面之相反面，且繞越卡合於刻設於最近之v形溝（】&)， 再從》亥V形溝（]心）繞越卡合於刻設於對邊側之v形溝 (1 6e) ’再度旋轉捲裝體（I 6)而予以捲繞至反對側面，並繞 34 317545 1360509 . 越卡合於刻設於最近之V形溝（16e)，再從該V形溝（16e) 繞越卡合於刻設於對邊側之V形溝（16e)’依此順序重複操 作’在繞越卡合於刻設於長邊側之全部V形溝（16e)後，將 止動器（25)卡合於溝（16g)而使捲裝體（〗6)不會轉動，再拉 出而將切斷前之試料載體（l〇a)之端部位置按下到試料集 積體（12)之核心部（12a)及頭部（13)之間並予以塞入，以令 頊部（13)緊接於核心部（12a)之前端之方式予以壓入，從而 鲁將試料載體（10a)強力地挾持，然後將於捲裝體〇6)之反對 側伸出之試料載體（10a)在頭部（13)及核心部（12a)所挾持 之位置之最近位置處、將多餘之試料載體（1〇a)切離，俾使 其末端不會飛出挾持位置，然後，將上蓋體（21a)安裝至下 盒體（21 b)，而組成試料集積用形態。 將已捲裝有試料載體（l〇a)之匣具（2〇)放置於點液裝置 之架台（42)之匣具載置部（41a)，再將分配構件（17)嵌入於 分配構件載置台（43b)之嵌入部（43c)，其中在該分配構件 # (17)中’突出構件（nb、…m)之前端部係已保持有收納於 排列在微平板狀容器之孔之1/4中之試料懸濁液，然後降 下移動台（43)到抵接於止動器（4ic)為止，從而在捲繞於安 裝至g具中之捲裝體（16)之試料載體（1〇a)上，按照預定之 排列狀附著試料懸濁液。然後，除去按下移動台（43)之力 量，藉彈簧捲片（44a)之彈簧作用，使移動台（43)上升，上 升後，取出分配構件⑼，將保持有收納在微平板狀容器 之孔之其他1 /4之試料懸濁液之分配構件（丨7)，以左右相 反狀重新嵌入，再度降低移動台（43)至抵接止動器（4ic)為 317545 35 1360509 止’從而針對已按照配布孔之1/4之排列狀附著有試料懸 濁液之試料載體（1 〇a)，在已附著各試料懸濁液之位置之中 間位置處’以配列孔之1/4之排列狀重新追加附著試料懸 濁液。 然後，上升移動台（43)，取出分配構件（π)，將安裝在 匣具（20)之捲裝體（丨6)加以反轉，且重新安裝在匣具載置台 (41 a) ’然後將新保持有微平板狀容器中配列孔之另外 孔中所收納之試料懸濁液之分配構件（〗7)加以嵌入，再降 下私動台（43)至抵接止動器（41c)為止，而按照預定排列狀 附著试料懸濁液，然後，除去按下移動台（43)之力量，藉 彈菁捲片（44a)之彈簧作用使移動台（43)上升後，取出分^ 構件，再將新持有微平板容器之孔之最後1/4中所收納之 試料懸濁液之分配構件（17)以左右相反狀予以嵌入，再度 降低移動台（43)至抵接止動器⑷。)為止，從而針對已按照 之1/4之排列狀附著有試料懸濁液之試料载體 (l〇a)，在已附著各簡t濁液之位置之中間位置處，以配 列孔之1/4之排列狀重新追加附著新試㈣濁液，而使試 料懸濁液以高密度附著在試料载體（1Qa)上。 。 令試料懸濁液附著於試料載體（1〇a)之後，藉由自然乾 知(數分鐘左右)使試料懸濁液乾燥之後，將 集積化裝置(50)之正面左侧…載置台 t加以支持=構件（54a)之前端料Ε具（2G)之孔（2 υ) t力以支持’同時使用定位構件⑽）防止其滑落，缺後摔 作載置台掛止構件（56)夕4 A 、 …'仗心 )之抓柄部分，解除掛止部和匣具載 317545 1360509 置台⑼之掛止用突起之間之卡合固枝態❹ 台（54)成為能移動至側壁（51b)側之狀態之後，㈣ 台（54)移向接近在正面右側之側壁⑽)之方向，而移動至 ner，⑽中為止。該時’除了解除栓鎖機構部 )的卡合固&狀_外，同時，鎖針（51e)亦按屋在厘具夹 具（21)之止動器（25)之抵接端（25e)，使跟捲裝體⑽卡二之A sample assembly mounting frame (not shown) is used in the suction pipe (11). In the ultraviolet central radiation device, it can be irradiated with ultraviolet light every week, and the full-batch material is solidified. 14) As shown in Fig. 1, the sample assembly (12) is used to manufacture and etch the sample assembly. (12) Manufacturing and method of use thereof, using the sample carrier (10a), the shaft member (14), the package distribution member (17), the sheath (20), and the liquid dispensing device (4) of the first embodiment When the sample accumulation device (50) and the sample assembly rotation device (6 inches) are used, the following is shown. The sample assembly (12) and the package (16) are mounted on the jig (21) of the sample collection tool (10), first in the state of the cover (21a) above the #TIf & jig (2). A sample assembly (12) in which a shaft member (14) is embedded and is a package sample carrier U〇a), and a package body (16) which is not packaged with a sample carrier, and then a sample assembly is mounted thereon. (12) In the state of the package (10), the sample carrier (i〇a) which is pulled out from the spool of the wound wire material is wound up in the package body (16). At the time of package, the end portion of the sample carrier (1〇a) is engaged and fixed to the hanging portion (16j), and the package body (6) is rotated to be wound up to the side of the hanging portion (the sentence). On the opposite side, and the winding is engaged in the nearest v-groove (] &), and then from the "H-shaped groove" (the heart) to the V-shaped groove engraved on the opposite side (1 6e) 'Rollly rotate the package (I 6) and wind it to the opposite side, and wrap around 34 317545 1360509. The more snapped into the nearest V-groove (16e), and then from the V-groove (16e) After the bypass is engaged with the V-shaped groove (16e) engraved on the opposite side, the operation is repeated in this order, after the winding is engaged with all the V-shaped grooves (16e) engraved on the long side, The stopper (25) is engaged with the groove (16g) so that the package body (?6) does not rotate, and then pulled out to press the end position of the sample carrier (10a) before cutting to The core portion (12a) and the head portion (13) of the sample assembly (12) are inserted between the head portion (13) so that the crotch portion (13) is pressed in front of the core portion (12a), thereby The sample carrier (10a) is strongly held and then placed on the package 6) The sample carrier (10a) protruding from the opposite side cuts off the excess sample carrier (1〇a) at the position closest to the position where the head (13) and the core portion (12a) are held, so that The end does not fly out of the holding position, and then the upper cover body (21a) is attached to the lower case body (21b) to constitute a sample accumulation form. The cookware (2〇) to which the sample carrier (1〇a) has been wound is placed on the cooker mounting portion (41a) of the stand (42) of the spotting device, and the dispensing member (17) is embedded in the distributing member An insertion portion (43c) of the mounting table (43b), wherein the end portion of the protruding member (nb, ... m) in the distribution member # (17) has been held in the hole arranged in the microplate-like container The sample suspension in /4, and then lowering the moving table (43) to abut against the stopper (4ic), thereby winding the sample carrier (1) wound on the package (16) mounted in the g-piece On 〇a), the sample suspension was attached in a predetermined arrangement. Then, the force of pressing the moving table (43) is removed, and the moving table (43) is raised by the spring action of the spring winding piece (44a). After rising, the dispensing member (9) is taken out and held in the micro-flat container. The other 1 / 4 of the sample suspension of the sample suspension (丨7) is re-embedded in the left and right opposite directions, and the moving table (43) is again lowered to the abutting stopper (4ic) to be 317545 35 1360509. The sample carrier (1 〇 a) to which the sample suspension has been attached in accordance with the arrangement of the distribution holes is 1/4, and is arranged at 1/4 of the arrangement hole at the intermediate position of the position where the sample suspension is attached. The sample suspension was reattached to the sample. Then, the moving table (43) is raised, the dispensing member (π) is taken out, the package (丨6) attached to the cookware (20) is reversed, and reinstalled on the cooker mounting table (41 a) 'then The distribution member (7) of the sample suspension accommodated in the other hole in which the hole is arranged in the microplate container is newly inserted, and the private table (43) is lowered to abut the stopper (41c). And attaching the sample suspension according to a predetermined arrangement, and then removing the force of pressing the moving table (43), lifting the moving table (43) by the spring action of the elastic crystal piece (44a), and taking out the component Then, the distribution member (17) of the sample suspension accommodated in the last 1/4 of the hole in which the microplate container is newly held is embedded in the left-right opposite direction, and the moving table (43) is again lowered to the abutting stopper. (4). Therefore, the sample carrier (10a) to which the sample suspension has adhered in accordance with the arrangement of 1/4 of the arrangement is arranged at the middle of the position where the turbid liquid is adhered. In the arrangement of /4, the new test (4) turbid liquid was newly added, and the sample suspension was attached to the sample carrier (1Qa) at a high density. . After the sample suspension is attached to the sample carrier (1〇a), the sample suspension is dried by natural drying (a few minutes or so), and then the front side of the stacking device (50) is placed on the table t. Support = member (54a) before the end of the cookware (2G) hole (2 υ) t force to support 'simultaneous use of the positioning member (10)) to prevent it from slipping, missing after the fall of the mounting table hanging member (56) eve 4 A , the grip part of the ''heart'), the unlocking part and the cookware load 317545 1360509 The engagement between the hanging protrusions of the setting (9) is fixed to the side wall (51b) After the state, the (four) stage (54) moves in the direction of the side wall (10) near the front right side, and moves to the ner, (10). At this time, in addition to the engagement and closing of the latch mechanism, the lock pin (51e) is also attached to the abutment end of the stopper (25) of the cleavage clamp (21) (25e). ), so that the package body (10) card two

抵接端吻)㈣簡除卡合侧㈣止動ϋ(25)和捲穿 體（16)間之卡合，使捲裝體（16)成為對於 知 構件，、叫為中心為可自由旋轉之狀態Λ、（21)^ 然後，將旋轉軸（52b)往接近試料集積體（12)之方向移 動，並令其前端部抵接於頭部（13)，使之能傳達旋轉力^ 試料集積體（12)。 捲裝體（16)成為自由狀態後，若轉動連結於驅動側齒 輪構件（52g)之把手（57)，則可使驅動側齒輪構件（52g)旋 轉，並由驅動侧齒輪構件（52g)透過中間齒輪構件（52h)轉動 #軸側齒輪構件（52f)。 如此’藉由轉動各齒輪，使卡合於旋轉軸（52 b)之前端 部之頭部（13)和試料集積體（12)—起轉動而從捲裝體（16) 捲取試料載體（l〇a)，同時藉彈簧捲片（53c)之彈簧彈推力， 令旋轉軸（52b)及導向軸（52c)慢慢移向側壁（5 la)側，而沿 著形成在試料集積體（12)之溝（12e)，以螺旋狀將試料载體 (l〇a)予以捲入。 將試料載體（l〇a)捲裝於試料集積體（12)之後，從匣具 (20)取出安裴有軸構件（14)狀態下之試料集積體（12)。取出 37 317545 1360509 之已捲裝有試料載體（1Ga)之試料集積體（12、...i2)，係藉 由將軸構件（14、...14)㈣於於試料集積體旋轉裝置 之旋轉軸（6卜...61)之各連結孔⑹a、...6】a)中而進行安裝。 將連接於已捲裝有試料載體（1〇a)之試料集積體 (12、...12)的軸構件（14、."14)予以内嵌於試料集積體旋轉 裝置（60)之旋轉軸（6〗、...61)之各連結孔（6〗a、…6^)中， 亚按壓按鈕(66a) ’使馬達(64)通電而起動，從而使旋轉轴 (61、"·61)轉動，並在確認開始轉動後，將試料集積體旋 轉裝置（60)置入紫外光照射裝置中，各試料集積體（12、… 12)係隨著旋轉軸（61、…61)之轉動而轉動，從而使紫外光 可均一地照射在各試料集積體（12、...12)之全周。 在照射紫外光而將附著於試料載體（1〇a)之試料予以 固定後，分離試料集積體（12)及軸構件（14)，並使用試料集 積肢女裝.，將试料集積體（12)收納於吸管（H)，使之可供 探針（10)用途。 使用該探針（10)之收納反應測定，係將探針（1〇)之下端 部插入至預先收容有含螢光物質且標識化之生物體物質之 懸濁液之容器中，並予以吸引到標識生物體物質懸濁液能 /X、/貝在试料集積體（12)之核心部（12a)之整體為止，使之能 和標識生物體物質中之結合性物質接觸，從而令附著在試 料載體（10a)之檢驗用生物體物質和標識生物體物質中之 結合性物質結合。 然後’從探針（10)之下端部排除所吸引之標識生物體 物質懸濁液’繼之’進行洗淨液之吸引及排除而洗淨吸管 38 317545 1360509 (11)内部，而洗除殘留之標識生物體物質懸濁液。 洗淨後，將測定用液體吸引至吸管⑴)内，在不使測 定用液體被排除之狀態下’將探針⑽安裝於收納反庫測 定裝置（未圖示）中，並從探針⑽外部向試料集積體⑽照 射紅色半導體雷射光，使固定於檢驗用生物體物f和標識 生物體物質中之結合性物f相結合之位置發光，且由受光 部接收該發光’而測定從核心部整體之發光位置，並由檢 測出之位置計測標識生物體物質中之結合性物f，而從所 有測得結合性物質之組合釐定目的物質。 如此之用以製造於吸管⑴）中收納有試料集積體（12) 之楝針⑽之-連串之作#，係藉由使用g具⑽、點液裝 1⑽)、試料#積化裝置⑽及試料集積體旋轉裝置⑽）而 衣造試料集積體（12) ’從而可以有效率且精度佳地製造小 型化之試料集積體（12)。(A) abutting the engagement side (4) the engagement between the stop ϋ (25) and the winding body (16), so that the package body (16) becomes a known member, and the center is freely rotatable State Λ, (21)^ Then, the rotating shaft (52b) is moved in the direction of approaching the sample assembly (12), and the front end portion thereof abuts against the head (13) so that it can transmit the rotational force ^ sample Collector (12). When the package body (16) is in a free state, when the handle (57) coupled to the drive side gear member (52g) is rotated, the drive side gear member (52g) can be rotated and transmitted by the drive side gear member (52g). The intermediate gear member (52h) rotates the #axis side gear member (52f). Thus, by rotating the gears, the head (13) that is engaged with the front end of the rotating shaft (52b) and the sample assembly (12) are rotated to take up the sample carrier from the package (16) ( L〇a), by the spring-loading force of the spring coil (53c), the rotating shaft (52b) and the guide shaft (52c) are slowly moved toward the side wall (5 la) side, and formed along the sample assembly ( 12) Groove (12e), the sample carrier (10a) is wound in a spiral shape. After the sample carrier (10a) is wound around the sample assembly (12), the sample assembly (12) in the state in which the shaft member (14) is mounted is taken out from the cookware (20). The sample assembly (12, ... i2) of the sample carrier (1Ga) which has been wound up in 37 317545 1360509 is taken out by the shaft member (14, ... 14) (4) in the sample assembly rotating device Mounting is performed in each of the connecting holes (6) a, ..., 6] a) of the rotating shaft (6b...61). The shaft member (14, . . . , 14) connected to the sample assembly (12, . . . 12) to which the sample carrier (1〇a) is wound is embedded in the sample assembly rotating device (60). In each of the connection holes (6, a, ..., 6) of the rotary shafts (6, ..., 61), the sub-press button (66a) 'energizes the motor (64) to start, thereby rotating the shaft (61, &quot ;·61) Rotate, and after confirming the start of rotation, the sample assembly rotating device (60) is placed in the ultraviolet light irradiation device, and each sample assembly (12, ... 12) follows the rotation axis (61, ... 61) The rotation is rotated to allow the ultraviolet light to be uniformly irradiated throughout the entire circumference of each of the sample assemblies (12, ... 12). After the sample attached to the sample carrier (1〇a) is fixed by irradiation with ultraviolet light, the sample assembly (12) and the shaft member (14) are separated, and the sample assembly is used to collect the sample. 12) Store in the straw (H) for use with the probe (10). In the storage reaction measurement using the probe (10), the lower end portion of the probe (1 〇) is inserted into a container in which a suspension containing the fluorescent substance and the labeled biological substance is stored in advance, and is attracted. The identification of the biological substance suspension energy /X, / shell in the core portion (12a) of the sample assembly (12) so that it can contact with the binding substance in the identification of the biological substance, thereby attaching The biological substance for testing of the sample carrier (10a) is combined with the binding substance of the labeled biological substance. Then, 'exclude the attracted biological substance suspension from the lower end of the probe (10) 'following' to attract and remove the cleaning liquid, and clean the inside of the suction pipe 38 317545 1360509 (11), and wash away the residue The identification of the biological substance suspension. After washing, the measurement liquid is sucked into the straw (1)), and the probe (10) is attached to the storage counter-measurement device (not shown) in a state where the measurement liquid is not removed, and the probe (10) is removed. Externally, the sample semiconductor assembly (10) is irradiated with red semiconductor laser light to emit light at a position where the test substance f and the binding substance f in the labeled biological substance are combined, and the light receiving unit receives the light emission and is measured from the core. The illuminating position of the whole part is measured, and the conjugated substance f in the labeled biological substance is measured from the detected position, and the target substance is determined from the combination of all the measured binding substances. The tandem needle (10) for accommodating the sample assembly (12) in the straw (1) is used by using g (10), liquid dispensing 1 (10), and sample #10 (10) Further, the sample assembly rotating body (10) can be used to fabricate the sample assembly (12)', whereby the miniaturized sample assembly (12) can be efficiently and accurately manufactured.

…據此，可將試料載體（1〇a)均—地捲裝於核心部（】2a)、 提南試料集積密度、使試料集積體及探針小型化，隨之可 ，測定裝置小型化，而降低I納反應測定有關經費。又， 隨之測定裝置之小型化可削減試料消費量，並且容易且精 f良好地製成試料集積體（12)，所以可提升作業效率，同 2可削減作業工量’大幅度提升製造探針⑽用之時間效 ，更可大幅度縮短需要更多試料集積體（1 P檢體之收納反應測定所料間，從委託檢驗到結^ =需總經過時間得以大幅度縮短，也能大幅 經費。 317545 39 1360509 藉由使用小型化且精度佳地製成之試料集積體（12)， 以及使用紅色半導體雷射光，而可提高收納反應測定中發 光位置之檢驗精度，同時可削減所用經費，得實現精度高 且廉價之收納反應測定。 第二實施形熊 以下况明使用將第-實施形態中之試料集積體及各種 裝置加以局部改良之裝置之情況。又，和第一實施形態相 同而未變更處僅附上相同符號而略去詳細說明。 如第23圖至第26圖所示’探針（1〇)係由吸管（11)和在 周面捲裝有形成絲狀之试料載體（1 〇a)之試料集積體（12)所 構成，而試料集積體（12)係由：其本體部形成為圓筒形， 同時.外周面刻設有用以捲裝試料載體（1〇a)之呈螺旋狀之 溝（12e)之核心部（12a);以及具備有令端部内嵌於核心部 (1 2a)之基側之新的中心定位部（丨2p)的把柄部（〗2c)所構 成。 把柄部（12c)係形成有：内嵌於核心部〇2)之前端側軸 部、和核心部（12a)之後端部一起形成〇形環溝（12f)之前端 側段差部、設有複數個肋部（12q)(圖示為4個）俾抵接於吸 管（11)之粗徑部（11 a)之内面而能定中心及定位的中心定位 部（12p)、位在中央部之圓柱部、以及形成於後端部而與其 他軸構件連接的連接部（12 h )，而形成具有複數外徑之軸構 件。 中心定位部（12p)之肋部（〗2q)及肋部（12q)之間，係形 成令所吸引之氣體及所吸引之液體容易通過之通路。 317545 40 頭口P (13) ’係以令核乂 德被而、十 〇P(12a)之則端面及頭部（13)之 後鳊面之間为離之方式 髀nn w义山 、叩耖動頭。P(13),從而可將試料載 體（l〇a)之刖钛部放入該 #丄 刀雖口，再糟由予以移動成令核 心部（12a)之前端面及 ^ m… ）之後端面之間相互抵接，而 ::二二也將試料載體〇〇a)之前端部強力挾持在兩構 ，之間’故在捲裝時，容易將試料載體⑽a)捲裝在核心部 (12a)。 收、内於吸g⑴）之試料集積體（丨2)係如第％圖所示， f以單純體使用，而係職具安裝用之軸構件（M)之前端 4所认之孔部（未圖示）予以外嵌於設於試料集積體⑽之 基。P之把柄部（12e)之連接部（12h)而進行同軸之連結。 又，亦可形成如第27圖至第31圖所示形狀，做為該 試料集積體之另一形態。 "亥另形怨係由：其本體部形成為圓筒形，同時於外 周面以螺旋狀刻設有用以捲裝試料載體（10a)之溝（12e)的 核〜°卩（12a)，以及將端部内嵌於核心部（12a)之基端側的把 柄部（12c)所構成。把柄部（12c)係形成有：内嵌於核心部 Ο 2a)之岫端側軸部（12r)、和核心部（12&)之後端部一起形成 〇形環溝（12f)之前端側段差部（12s)、形成〇形環溝（12f) 之把柄側之端面的護手部（丨2t)、立設複數個之肋部 (12qX圖示為4個）俾抵接於吸管（11)之粗徑部（ila)之内面 而可定中心及定位的中心定位部（12p)、在護手部（12t)及中 心定位部（12P)之間以較護手部（12t)縮小外徑之方式形成 的圓柱狀之把柄部（丨2C)、從中心定位部（12p)之後端面突出 41 317545 1360509 之#又差部（12u)、以及在段差部（12u)之後方用於和其他軸構 件連接的連結部分（12h) ’而形成具有複數個外徑之軸構 件。在中心定位部（12p)之肋部（12(})及肋部（12q)之間，形 成有使所吸引之氣體及所吸引之液體更容易通過之通路， 同時使軸構件（14)之嵌合部分與液體分離、而不會被浸 濕’使後處理容易，並可回避殘留液體之不必要之困擾。 另外，也可形成為如第47圖及第48圖所示形狀，做 為試料集積體（12)之第27 至第31圖所示形態的其他形 匕八中第47圖及第48圖中，和前述圖面所示符號相 同的付波係表不同一者，故略去說明。 該形態中，做成可挾持試料載體（10a)之前端部之頭部 (13)’係和上述形態同樣地’藉由與核心部同轴地嵌 合之中央部之軸構件(13b)而以在軸方向可自由移動之方 式連結之。然而，不同於前述形態，在核心部〇2a)之前端 部’係於軸方向前方突設有突出部（12w)，該突出部（i2w) 係具有弧狀斜邊之大約直角三角形之橫剖面，同時，在鄰 接於突出部（12w)之核心部（12a)之前端部中，在軸方向後 方，係穿設有凹處（12v)，該凹處〇2v)係由具有弧狀斜邊之 勺直角一角形之杈斷軸方向而形成之前端面、以及和前 端面之各為垂直之兩個垂直之側面所圍成，且其前端面之 約二角形狀之直角部係由三個平面形成頂點。突出部（】2w) 之垂直相交之二個側面中之__個，係和圍成凹處（】叫之一 =糟共同平面合成大約L字狀，其他一側面和其側面呈 人在頭β (1 3)之後端部，係朝轴方向後方突設有配合 317545 42 1360509 • 76b)之突設有軸構件（76e、76e)之位置之偏向 •‘成有長方形狀之凹處（76d、76d)，並#4 ♦ J亚在兩長邊側之板狀外 周壁（76e)之上下各面以等間距刻設以v形溝⑽、… 76f)’俾使刻設於各邊之v形溝⑽、...76f)分別偏移半個 間距。 又’在平板（76a)之上下各面，係穿設有多條從各面向 空心部分貫穿之細長孔（76g、...74)(圖中示16支），且係 籲穿設成相對於轴構件（76c、76c)之中心線保持傾斜角且互 相平行。孔（76g、…76g)之傾斜角相對於設在試料集積（12) 之溝（12e)之傾斜角大約呈垂直角度為宜。特別是，孔 (76g、·. 76g)之傾斜角亦可用與刻設有v形溝（76f、… 之長邊側之板狀外周壁（76e)之間的角度來表示。該情形 下，孔（76g、_··76^之傾斜角係形成為，刻設在兩長邊側 之板狀外周壁（76e，76e)之V形溝（76f、…76f)上所卡合繞 越之試料載體相對於孔（76g、…76g)係呈垂直交叉。 φ 捲裝體（76)之尺寸，係對應於分配構件（17)之突出構件 (17b)所配置位置及其展幅之大小，而設定平板（76a)之尺 寸、孔（76g、…76g)之穿設位置、v形溝（76f、…76f)之刻 設位置等。 捲裝體（76)係於形成有凹部（76d、76句之板狀外周壁 (76b、76b)之凹部形成側的相反側之角部，形成用以卡合 旋轉鎖之溝（76h)(參照第34圖及第35圖）。 再者，於捲裝體（76)中，在與形成凹部（76d、76d)之板 狀外周壁（76b、76b)大約以直角連結之長邊側之板狀外周 44 317545 1360509 壁（76e，76e)之至少靠近設置凹部（76d、76d)之端部之板狀 外周壁（76e)之外端面（76i)，穿設有細長孔（76j)，從而預備 ㈣液位置，以便將旋濁有做為標示劑之試劑的旋濁液附 著於透過V形溝（76f、...760繞越架設之試料载體（1〇a)。 在捲裝體（76)之角部’係形成有用以卡合固定試料載 體（_之-端部、以狹縫狀形成之試料載體前端部之掛止 部（76k)。 捲裝試料載體（10a)於該捲裝體（16)時，係將試料載體 (l〇a)之前端部打結，利用掛止部（76k)卡合固定該打結後， 依照預定之捲裝順序，由V形溝（76f)向另一 v形溝 繞越架設’從而捲裝在各v形溝（76f'…76f)。 其次，使整體呈圓角狀、將突出構件收納於蓋體内、 且使凹凸盡量不要顯露於外之試料集積用匣具（80)係如第 34圖及第35圖所示，乃由安裝有試料集積體⑽及捲裝體 (16)之£具夾具⑻）所形成’並將昆具夾具㈣分割為做為 外殼，上蓋體陶及下蓋體(81b)，而在移開上蓋體㈣ 之狀態下’將捲裝試料載體〇〇a)前之狀態之試料集積體 (12)及未捲裝試料载體〇〇a)之捲裝體（]6)予以組裝，'並= 狀態下將試料载體〇〇a)捲裝於捲裝體⑽。試料集積體(;;) 係以嵌有軸構件（14)之狀態下進行安裝。 T先，將試料載體（1〇a)之前端部卡合固定於掛止部 (76k)^然後捲繞於掛止部（76]〇之形成側面及反對側面，而 卡合繞越於未卡合固定有試料載體（1Ga)之刻設於最近之v 形;冓（76f) ’再m形溝（76f)卡合繞越至刻設於對邊側之 3Ϊ7545 45 1360509 V形溝（76f)，再捲繞至反對側面，而卡合繞越於未卡合固 •定有試料載體（10a)之刻設於最近之V形溝（76f)，再從該V •形溝（76f)卡合繞越至刻設於對邊側之v形溝（76f)，按照上 述順序重複進行，直到卡合繞越至刻設於長邊側之所有v 形溝（76f)後，將試料載體（1〇a)之（切斷前）端部位置予以壓 下而塞入至試料集積體（12)之核心部（12a)及頭部（13)之 間，並將頭部（13)以緊密抵接於核心部（12a)之前端之方式 予以壓入，而強力挾持試料載體（1〇a)，於露出於捲裝體（Μ) 相反側之試料載體（10a)被挾持於頭部（1 3)及核心部〇 2心 之位置最近之位置處，將多餘之試料載體（1〇a)予以切離， 之後，女装上蓋體（21 a)而組成為試料集積用之形態。 匣具失具（81)係由設置有可自由旋轉地嵌合試料集積 體（12)之安裝孔（81c)之中央構件（81句、及從該中央構件 (81d)之端部以大約直角方向突出之側面支持構件（we、81f) 形成為門形，藉由將嵌入在捲裝體（76)之軸構件（76e 76c) •的旋轉李由（22、22)分別予以可自由旋轉地嵌入各側面支持 構件（8le、81f)中，從而安裝成使捲裝體（76)可自由旋轉。 匣具夾具（81)在其中央構件（81d)之一端係穿設有相當 於軸承之孔（81g)，且該孔（81幻係連接於安裝孔（8ic)，俾 ^試料集積體（12)及所嵌合之軸構件（14)可自由旋轉地被 甘欠接，而他端則穿設有用以插入夾具的孔（8】h，8ih)，並 亦連接方；安裝孔（8ic)，其中該夾具乃用於使頭部⑴)移向 氏接核心部(]2a)之方向而挾持試料載體〇〇a)之端部位 置。再者，在令央構件（81d)之形成安裝孔處之外側係形成 317545 46 1360509 藉邊緣做成緩和曲線而容易用手指接觸之鎖口（83a、 k . 83b)，提供上蓋體（8〗a)及下蓋體（81b)容易安裝或卸裝用 * 途’以及在罪近側面支持構件（81 e、81 f)之位置處形成定 位用突起（未圖示）及孔（84b、84b)。 又’在一方之側面支持構件（81 f) ’係樞接有做為捲裝 體（76)之旋轉檔止用的止動器（25)。該止動器（25)係形成有 在中央部穿設有轴孔（25a)的柩接部’其一端係設置向捲裝 鲁體（76)側突出之抵接端（25C)，在該抵接端（25c)之内側係抵 接有將該抵接端（25c)向捲裝體（76)側予以彈推之板彈箬 (2 5 d) ’他端則在板彈養·所抵接之面之相同面上突出有當解 除旋轉檔止時用以抵接於推桿的抵接端（25e)。 各側面支持構件（81e、81f)之外側面係穿設有孔（8Η、 8H)，以便讓嵌入有旋轉軸（22、22)之捲裝體旋轉用夾具或 點液裝置之捲裝體旋轉軸能夠嵌入，同時也穿設有孔 (81j、81j)，以便讓抵接於止動器（25)之抵接端（25c)以解除 鲁旋轉檔止用工具或點液裝置之銷針能夠插入。 在側面支持構件（8 le、81f)之下蓋體（8ib)側之前端， 係突設有卡合用孔側突出構件（26)，在側面支持構件 (81e、81f)之上蓋體（2la)側之前端，係突設有卡合用軸側 大出構件（27) ’該卡合用軸側突出構件（27)係卡合於下蓋體 (211〇側之卡合用孔側突出構件（26)。 於匣具夾具（81)中組裝了安裝捲裝試料載體（1〇a)前之 試料集積體（12)及已捲裝試料載體（1〇a)之捲裝體（76)而構 成之匣具（80)中，係穿設各側面支持構件（8le、8if)之旋轉 317545 47 1360509 樞接孔（81k、m)，俾使試料集積體⑽之軸心及捲裝體（76) 之、’田長孔（76g、大約成為平行狀，且具有配合試料 集積體⑽之用以捲裝試料載體（1〇a)之溝⑽）之傾斜角 的傾斜角而予以安裝。According to this, the sample carrier (1〇a) can be uniformly wound in the core portion (] 2a), the sample density of the sample can be increased, and the sample assembly and the probe can be miniaturized, and the measuring device can be miniaturized. , while reducing the I-reaction determination related to the funding. In addition, the reduction in the size of the measurement device can reduce the amount of sample consumption, and the sample assembly (12) can be easily and accurately prepared. Therefore, the work efficiency can be improved, and the amount of work can be reduced by the same amount. Needle (10) can be used for a long time, and it can greatly shorten the need for more sample aggregates (1 P sample storage reaction measurement, from commissioned inspection to completion ^ = total time required to be greatly shortened, can also be significantly 317545 39 1360509 By using a sample assembly (12) made of small size and high precision, and using red semiconductor laser light, the inspection accuracy of the light-emitting position in the storage reaction measurement can be improved, and the cost can be reduced. In the second embodiment, the apparatus for partially improving the sample assembly and various devices in the first embodiment will be used. The same as the first embodiment. The same reference numerals are attached to the unaltered parts, and the detailed description is omitted. As shown in Figures 23 to 26, the probe (1〇) is attached by a straw (11) and wound on the circumference. The sample assembly (12) of the filament-like sample carrier (1 〇a) is composed of the sample assembly (12), wherein the body portion is formed into a cylindrical shape, and the outer peripheral surface is engraved with a roll. The core portion (12a) of the spiral groove (12e) of the sample carrier (1〇a) is mounted; and a new central positioning portion having the end portion embedded in the base side of the core portion (12a) is provided (丨The handle portion (12c) of 2p) is formed. The handle portion (12c) is formed by being embedded in the front end side shaft portion of the core portion )2) and forming a circular ring groove together with the rear end portion of the core portion (12a). (12f) The front end side step portion is provided with a plurality of ribs (12q) (four shown) 俾 abutting against the inner surface of the large diameter portion (11 a) of the straw (11) to be centered and positioned The central positioning portion (12p), the cylindrical portion at the central portion, and the connecting portion (12h) formed at the rear end portion and connected to the other shaft members form a shaft member having a plurality of outer diameters. Between the rib (?2q) and the rib (12q) of the center positioning portion (12p), a passage for allowing the attracted gas and the attracted liquid to pass easily is formed. 317545 40 Head P (13) ' is the way to make the nuclear 被 、 , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , Moving head. P(13), so that the titanium portion of the sample carrier (l〇a) can be placed in the mouth of the #丄刀, and then moved to the end face of the core portion (12a) and the end face after ^m...) They are in contact with each other, and:: 22 also holds the sample carrier 〇〇a) at the front end of the sample at the same time, so that it is easy to roll the sample carrier (10) a) to the core (12a) during the package. . The sample assembly (丨2) for receiving and sucking g(1) is as shown in the % diagram, f is used as a simple body, and the hole portion recognized by the front end 4 of the shaft member (M) for attachment is attached ( Not shown) is externally embedded in the base of the sample assembly (10). The connection portion (12h) of the handle portion (12e) of P is coaxially coupled. Further, a shape as shown in Figs. 27 to 31 can be formed as another form of the sample assembly. "Hai's other form of resentment consists of: the body portion is formed into a cylindrical shape, and the core of the groove (12e) for winding the sample carrier (10a) is spirally engraved on the outer peripheral surface, And a handle portion (12c) in which the end portion is fitted to the base end side of the core portion (12a). The shank portion (12c) is formed by: a side end side shaft portion (12r) embedded in the core portion a 2a) and a rear side portion difference formed by forming a 〇-shaped annular groove (12f) together with the rear end portion of the core portion (12&) a part (12s), a hand guard portion (丨2t) forming an end surface on the handle side of the circular ring groove (12f), and a plurality of rib portions (four shown in Fig. 12q) are erected to abut the suction pipe (11) The inner positioning portion (12p) that can be centered and positioned on the inner surface of the large diameter portion (ila), and the outer diameter of the hand guard portion (12t) between the hand guard portion (12t) and the center positioning portion (12P) The cylindrical handle portion (丨2C) formed by the method, protrudes from the rear end portion of the center positioning portion (12p), and then the rear end portion (12u) of the 41 317545 1360509 and the rear portion (12u) are used for the other axes. The connecting portion (12h) of the member is connected to form a shaft member having a plurality of outer diameters. Between the rib (12 (}) and the rib (12q) of the center positioning portion (12p), a passage for allowing the attracted gas and the attracted liquid to pass more easily is formed, and at the same time, the shaft member (14) is The fitting portion is separated from the liquid without being wetted, which makes the post-treatment easy, and avoids the unnecessary trouble of the residual liquid. Alternatively, it may be formed into a shape as shown in Figs. 47 and 48, as In the 47th and 48th drawings of the other forms of the form shown in the 27th to 31st sheets of the sample assembly (12), the same wave wave table as the one shown in the above figure is different, so In this embodiment, the head portion (13)' at the end portion of the sample carrier (10a) can be held in the same manner as the above-described configuration, and the shaft member of the center portion that is coaxially fitted to the core portion is 13b) is connected in such a manner as to be freely movable in the axial direction. However, unlike the above-described embodiment, the end portion 'before the core portion 〇2a) is provided with a protruding portion (12w) protruding in front of the axial direction, the protruding portion ( I2w) is a cross section of an approximately right triangle with an arcuate beveled edge, and adjacent to the protrusion In the front end of the core portion (12a) of (12w), in the rear of the axial direction, a recess (12v) is formed, and the recess 〇 2v) is cut by a right angle of an arc with a curved bevel. The front end surface is formed in the axial direction, and the two perpendicular side surfaces perpendicular to the front end surface are formed, and the right-angled portions of the front end surface of the two-corner shape are vertices formed by three planes. __ of the two sides of the vertical intersection of the protrusion (] 2w), the system and the surrounding recess (called one of the = common surface synthesis of about L-shaped, the other side and its side are in the head The rear end of β (1 3) is protruded rearward in the axial direction. The 317545 42 1360509 • 76b) is provided with the position of the shaft member (76e, 76e). • The rectangular shape is recessed (76d). , 76d), and #4 ♦ J is placed on the upper and lower sides of the plate-like outer peripheral wall (76e) on the two long sides at equal intervals with a v-shaped groove (10), ... 76f) '俾 so that it is engraved on each side The v-grooves (10), ... 76f) are offset by a half pitch, respectively. Further, 'on the lower surface of the flat plate (76a), a plurality of elongated holes (76g, ... 74) penetrating from the respective hollow portions are formed (16 pieces are shown), and are designed to be relatively The centerlines of the shaft members (76c, 76c) are maintained at an oblique angle and are parallel to each other. The inclination angle of the holes (76 g, ... 76 g) is preferably about a vertical angle with respect to the inclination angle of the groove (12e) provided in the sample accumulation (12). In particular, the inclination angle of the hole (76g, ·.76g) can also be expressed by an angle with the plate-like outer peripheral wall (76e) on the long side of the v-shaped groove (76f, ...). In this case, The inclination angles of the holes (76g, _··76^ are formed so as to be engaged with the V-shaped grooves (76f, ..., 76f) of the plate-like outer peripheral walls (76e, 76e) of the two long sides. The sample carrier is vertically intersected with respect to the holes (76 g, ... 76 g). The size of the φ package (76) corresponds to the position of the protruding member (17b) of the distribution member (17) and the extent of its stent. The size of the flat plate (76a), the insertion position of the holes (76g, ... 76g), the position of the v-shaped grooves (76f, ... 76f), and the like are set. The package body (76) is formed with a recess (76d, The concave portion of the plate-shaped outer peripheral wall (76b, 76b) of 76 sentences forms a corner portion on the opposite side to the side, and forms a groove (76h) for engaging the rotary lock (refer to Figs. 34 and 35). In the package body (76), at least the plate-like outer periphery 44 317545 1360509 (76e, 76e) on the long side of the plate-like outer peripheral wall (76b, 76b) forming the recesses (76d, 76d) is connected at a right angle. by The outer end surface (76i) of the plate-shaped outer peripheral wall (76e) at the end of the recess (76d, 76d) is provided with an elongated hole (76j) to prepare a liquid position for the purpose of using the turbidity as a marker. The turbid liquid of the reagent adheres to the sample carrier (1〇a) which is circumscribing through the V-shaped groove (76f, ... 760. The corner portion of the package body (76) is formed to be used to fix the sample. The carrier (the end portion, the end portion of the sample carrier formed in the slit shape, the hanging portion (76k). When the package carrier (10a) is wrapped in the package (16), the sample carrier (1) is used. a) Before the end knot is knotted, after the knot is fixed by the hook portion (76k), the V-shaped groove (76f) is erected to the other v-shaped groove in accordance with the predetermined package order. In each of the v-shaped grooves (76f'...76f), the sample-forming cookware (80) is placed in a rounded shape as a whole, and the protruding member is housed in the lid and the unevenness is not exposed as much as possible. 34 and 35 are formed by the fixture (8) to which the sample assembly (10) and the package (16) are attached, and the fixture (4) is divided into outer casings. A sample assembly (12) and an uncoated sample carrier in a state in which the lid body and the lower lid body (81b) are in the state in which the upper lid body (4) is removed, and the sample carrier 〇〇a is packaged. The package body (a) of a) is assembled, and the sample carrier 〇〇a is wound up in the package body (10). The sample assembly (;;) is embedded with a shaft member (14). The mounting is performed in a state of T. First, the front end portion of the sample carrier (1〇a) is engaged and fixed to the hanging portion (76k), and then wound around the side surface and the opposite side of the hanging portion (76). The snap-fit is placed on the nearest v-shape when the sample carrier (1Ga) is not engaged; the 冓(76f) 're-m-shaped groove (76f) is snapped around the 3Ϊ7545 45 which is engraved on the opposite side. 1360509 V-shaped groove (76f), re-wound to the opposite side, and the engagement around the unengaged and fixed sample carrier (10a) is set in the nearest V-shaped groove (76f), and then from the V • The groove (76f) is snapped to the v-shaped groove (76f) which is provided on the opposite side, and is repeated in the above-described order until the snap-fit is passed to all the v-grooves (76f) which are provided on the long side. After the sample carrier (1〇a) Before the cutting, the end position is pressed and inserted between the core portion (12a) and the head portion (13) of the sample assembly (12), and the head portion (13) is tightly abutted against the core portion ( 12a) The front end is pressed in, and the sample carrier (1〇a) is strongly held, and the sample carrier (10a) exposed on the opposite side of the package (Μ) is held on the head (13) and the core最近2 The position of the heart is closest to the position, and the excess sample carrier (1〇a) is cut away. Then, the women's upper cover (21 a) is formed into a sample for sample accumulation. The cookware dislocation (81) is a central member (81 sentences, and a right angle from the end of the central member (81d) provided with a mounting hole (81c) to which the sample assembly (12) is rotatably fitted. The laterally supporting side support members (we, 81f) are formed in a gate shape, and the rotation lee (22, 22) of the shaft member (76e 76c) embedded in the package body (76) is rotatably respectively It is fitted into each of the side support members (8le, 81f) so as to be mounted so that the package body (76) can be freely rotated. The cooker jig (81) is provided with a hole corresponding to the bearing at one end of the central member (81d). (81g), and the hole (81 phantom is connected to the mounting hole (8ic), the sample assembly (12) and the fitted shaft member (14) are freely rotatably connected, while the other end is a hole (8]h, 8ih) for inserting a jig, and also a connecting hole; a mounting hole (8ic), wherein the jig is used to move the head (1)) toward the core portion (] 2a) The position of the end of the sample carrier 〇〇a) is maintained. Furthermore, the outer side of the central member (81d) is formed at the outer side of the mounting hole to form a 317545 46 1360509. The edge is made into a gentle curve and is easily contacted by fingers (83a, k. 83b), and the upper cover is provided (8). a) and the lower cover (81b) are easy to attach or detach, and the positioning protrusions (not shown) and the holes (84b, 84b) are formed at the positions of the sin proximal support members (81e, 81f). . Further, a side stopper member (81 f) ′ is pivotally connected to a stopper (25) for rotation of the package body (76). The stopper (25) is formed with a splicing portion that is provided with a shaft hole (25a) at a central portion thereof, and one end thereof is provided with an abutting end (25C) protruding toward the package body (76) side, where The inner side of the abutting end (25c) abuts a plate magazine (2 5 d) that pushes the abutting end (25c) toward the side of the package body (76), and the other end is in the plate. The abutting end (25e) for abutting against the push rod when the rotation stop is released protrudes from the same surface of the abutting surface. The outer side surfaces of each of the side support members (81e, 81f) are provided with holes (8A, 8H) for rotating the package rotating fixture or the liquid guiding device of the rotating shaft (22, 22). The shaft can be embedded and also provided with holes (81j, 81j) for abutting against the abutting end (25c) of the stopper (25) to release the pin of the lug rotation stop tool or the liquid dispensing device. insert. At the front end of the side cover member (8 le, 81f) on the side of the cover body (8ib), a engaging hole side projecting member (26) is provided, and a cover body (2a) is provided on the side support members (81e, 81f). The front end of the side is provided with a shaft-side large-outlet member for engagement (27). The engagement-side shaft-side projecting member (27) is engaged with the lower cover body (the engagement hole-side projecting member (26) on the side of the 211' side) The sample assembly (12) before mounting the package sample carrier (1〇a) and the package body (76) of the packaged sample carrier (1〇a) are assembled in the cooker jig (81). In the cooker (80), the rotation of the side support members (8le, 8if) 317545 47 1360509 pivot holes (81k, m) are passed through, and the axial center of the sample assembly (10) and the package (76) are The 'Taiwan hole (76 g, approximately parallel, and having the inclination angle of the inclination angle of the sample carrier (10) for winding the sample carrier (1〇a)) is attached.

、，再者，將驅動部及載置台掛止構件集中於基座之右相 亚以f料以覆蓋、同時亦將彈簧裝置、阻尼部及检鎖相 構部等也以蓋體予讀蓋的試料㈣化裝置㈣），係如第 36圖至第40圖所係由下列構件所構成··基座⑺），係 =正面右端側部分留下間距，將正面形狀形成為凹狀，且 设立有兩個側壁（9la，91b);驅動部（52)，係安裝於各側壁 (Wa 9]b)之間’而可使試料集積體（12)及捲裝體（μ)同步 7車同％•可使β式料集積體（】2)往車由方向移動；蓋體（9】〇)， ，設置於兩個側壁（91a，9】b)之外周，俾覆蓋驅動部·彈 t裝置（53)，係當試料集積體（12)向轴方向移動時賦予彈箬 =以便使直線移動容易；11具载置台⑻，係以傾斜 匣具（80)且能以接近或遠離側壁（9la9ib)之方向直 動，支持台（55)，係具備有用以可直線移動地 ^置台⑻之直動歸；及載置台掛止構件（％)，係當將 二置在正面左側之側壁（叫之匿具㈣予以安裝或卸除之 不、防止£具載置台（54)向轴方向移動而予以卡合固定。 = (91b)之間係設置有朝向g具載置台⑽之側端部 央部並以水平方向突出之®具安裝用銷針（5】e)。 驅動部（52)之構成包括：旋轉軸（52)，具有用 W具⑽)之試料集積體⑽之頭部（】3)的前端部，且 3]7545 48 1360509 =為可向軸方向移動；導向軸叫當將已完成軸方向 :二=卿以復歸至原位置時，用於抵抗旋轉鎖 ，彈堆力而往復歸方向予以拉回；連接構 將疑轉軸⑽)及導向師叫在突出蓋體（52a)之外面之端 :二以連結，同時兼有拉回抓柄之用途；轴側齒輪構件 ^ )，係由給與旋轉軸（52b)轉動力、同時支持軸方向之移 ，用的軸承所構成；附單向離合器之驅動側齒輪構件 係藉由手動給予旋轉力，同時傳達驅動力到旋轉軸 ，以及中間齒輪構件（52h)，係以可連動之方式連接軸 側齒輪構件（52f)及驅動側齒輪構件（52g)。 在旋轉軸（52b)中，在周面上以圓周上等分之方式刻設 2矛中^軸平行之溝（52l)，而用於將軸側齒輪構件 ^旋轉力變換成為旋轉轴（52b)之前進力之銷針（未圖示）係 =轴側齒輪構件（52f)之内周面向中心側突出，同時銷針之 前端部係形成具有可移動自如地向軸向插入溝（52i)之長 鲁度及粗細。 又，在驅動側齒輪構件（52g)中，在軸端部係外嵌有突 出T壁（91a)外面之手動用把手（57)，隨轉動該把手乃之 手指動作而旋轉驅動側齒輪構件（52g)，從而從驅動側齒輪 構件（52g)介由中間齒輪構件（52h)傳達旋轉力到軸側齒輪 構件（52f)，再由軸侧齒輪構件（52f)傳達驅動力到旋轉軸 (52b) 〇 匣八載置台（54)之上面，在左側位置之側端部之上面 中央部之端緣，係突設有樞接構件（54a)，其係將前端部插 317545 49 1360509 入至設於匣具（80)之側面支持構件（8 le)之孔（21j)中而予以 支持’在左側下端之角部並突設有可防止匣具（2〇)滑落之 定位構件（54b)。又’匣具（80)之側面支持構件（81f)之右側 下端之角部，也突設有防止匣具滑落用之定位構件（54c)。 載置台掛止構件（96)，係在側壁（91 b)之驅動部配置側 設置有以旋轉軸（96b)為中心、並形成可搖動狀的曲尺狀構 件（96a)，且設置有貫通側壁（9ib)、並將位於曲尺狀構件 (96a)之掛止端相反側之端部與導向軸（52c)之動作連動而 鲁予以推壓之解除掛止構件（96c)，當匣具載置台（54)靠近側_ 壁（9 lb)時’使曲尺狀構件（96a)往掛止側動作，而將突出於 S具載置台（54)之背面側（即下面）之側端部之掛止構件 (54e)予以卡合固定’而將匣具載置台（54)固定在靠近侧壁 (91b)側之位置。 在匣具載置台（54)之背面側，係配設有彈簧裝置（53)、 阻尼部（5 8)、及栓鎖機構部（59)，並安裝覆蓋這些構件的蓋 癱體（96d)。 彈簧裝置（53)之構成包括：立設於匣具載置台（54)之背 面側之彈簧裝置用之托架（53a)、以可自由轉動之方式安裂 於托架（53a)之捲線筒（53b)、以及捲繞該捲線筒（53b)同時 將其自由端側固定在導向軸（52c)之前端部的彈簧捲片 (53c)。 ’ 阻尼部（58)之構成包括：阻尼用托架（58a)、以及設置 有嚙合於設置在導向軸（52c)之阻尼用齒輪（未圖示）的阻尼 側齒輪（未圖示）的阻尼裝置（58c)。阻尼裝置（58匀係使用油 317545 50 1360509 阻式之旋轉阻尼以防止急速移動。 栓鎖機構部（59)之構件包括：從導向軸（52c)之前端部 ，下垂之掛止構件（59a);以可繞著軸心搖動之方式安裝在托 架（58a)之鎖固構件（59b);以及上端固定在匣具載置台（54) 且以可直線前進移動之方式形成，同時將鎖固構件（59b) 之非掛止側端部按壓至解除掛止側之解除掛止構件（59C)。 在導向軸（52c)之前端部和彈簧捲片（53b)間之固定部 籲分中，當掛止構件（59a)之下端部卡合固定在鎖固構件（59b) 之掛止側端部時，若將匣具載置台（54)移向接近側壁（51b) 之方向，令解除掛止構件（59c)將該鎖固構件（59b)之非掛止 側端部按壓至解除掛止側，而解除掛止構件（59a)和鎖固構 件（59c)之間的連結時，則會藉彈簧捲片（53c)之彈推力，在 受到阻尼裝置（58c)之抗力下，將導向軸（52c)朝向接近侧壁 (5 1 a)之方向移動。 當為了連結旋轉軸（52b)之前端部卡合在試料集積體 φ (2)之頭。卩（13)，而將連結構件（92d)拉向側壁（9ia)之外面， ，試料集積化裝置（9G)能操作g具州時，栓鎖機構部⑽ 係起作用而卡合固定成不會回到原位置，而當安裝成可操 作匣具之狀態後，解除掛止而藉彈簧捲片（53c)之彈菩彈推 力將旋轉軸（52b)朝向側壁（51b)之内面移動時，阻尼裝置 ⑽)係對導向軸（52e)賦予適當之抵抗力以便控制移動速 度’俾使其不會急遽地移動。 錢料集積化裝置（9〇)係如第41圖及第42圖所示， 將昆具_載置在！I具載置台（54)上，並將枢接構件（54a) 317545 51 1360509 之前端部插入S具（80)之孔（81j)而予以支持，同時以卡合 用孔側突出構件（26)及卡合用轴側突出構件⑼之突出部 為導執，藉定位構件（54b，54C)大約定位並防止滑落之後， 將E具載置台（54)向靠近正面右側之側壁（91b)方向移動， 而一旦移動至銷針（5le)插入孔（81j)為止時，係解除检鎖機 構部（59)之卡合固定，同時銷針（51e)係按屢度具夹具⑺） 之止動器（25)之抵接端（25e)，使連結捲裝體（76)之止動器 (25)之抵接端（25e)移向解除卡合側，而解除止動器乃及 捲裝體（16)間之卡纟’使捲裝體⑽成為相料g具夾具 (21)以軸構件（16c、16c)為中心可自由旋轉之狀態。 此時，在銷針（51e)插入孔（81j)為止前，载置台掛止構 件（96)之解除掛止構件（96c)係往解除掛止側移動，而按壓 曲尺狀構件（96a)之掛止端側相反側之端㉛，從而解除設置 在匿具載置台（54)之背面側之掛止構件（Me)與曲尺狀構件 (96a)之掛止端之間之卡合固定（掛止）狀態。 然後，將旋轉軸（52b)向靠近試料集積體（12)之方向移 動’使前端部卡合於頭部（13) ’從而能夠傳達轉動力至試 料集積體（12) ’同時隨導向軸（52c)之移動，載置台掛止構 件（96)之解除掛止構件（96c)係往掛止方向移動，使曲尺狀 構件（96a)之掛止端卡合固定於設在匣具載置台（54)之背面 側之掛止構件（54e)，而固定匣具載置台（54)之位置。 當捲裝體(76)成為自由狀態後，若轉動連結在驅動側 齒輪構件（52g)之把手（57)時，則驅動側齒輪構件（52g)會轉 動，並由驅動側齒輪構件（52g)透過中間齒輪構件汕)^動 317545 52 1360509 軸側齒輪構件（52f)。如此藉由轉動各齒輪，使卡合於旋轉 ••轴（52b)之前端部之頭部（13)和試料集積體（12) 一起轉動， -而從捲裝體（76)捲取試料載體（10a)，且由於嵌鎖機構部（59) 已解除卡合岐，故可藉由彈簧捲片（53e)之彈簧彈推力而 令旋轉軸（52b)及導向軸（52c)慢慢移向離開側壁（91b)之方 向，而依隨形成在試料集積體（12)之溝〇2e)以螺旋狀捲繞 試料載體（10a)。 φ 關於製造第二實施形態之試料集積體之方法，到將試 料懸濁液附著於設置在£具（80)之捲裝體（76)上為止之作 業，可按照與第一實施形態相同之順序進行，即使在從捲 裝體(76)捲裝在試料集積體(12)之作業中，使載置台掛止構 件（96)與旋轉轴（52b)及導向軸（52c)之操作連動而予以卡 合固定或解除卡合之處雖然有差異，但是由於其他作業皆 可按照與第-實施形態相同之順序進行，所以不再說明。 又’關於由第二實施形態所製造試料集積體之使用，由於 •和第-實施形態所製造試料集積體〇2)相同，所以其使用 (例如收納反應測定）也跟第一實施形態所記載之使用相 同’也省略其說明。 如此，即使變更各裝置，都能使試料集積體（12)有效 1且高精度地製成，所以較第一實施形態更容易利用，可 製成有效率且精度良好之試料集積體（】2)。 1·^實施形熊 ^兼具點液裝置（40)及試料集積化裝置（50)之簡易裝置 仏做為第三實施形態而說明如下。 337545 53 1360509 點液、集積化兼用裝置（100)如第43圖及第44圖所 示，由做為點液裝置之底座（⑻）、及做為用以保持試料集 積體（12)及捲裝體（16)之試料集積化裝£的保持構件⑽) 所構成。 底座（101)乃在長方向為橫向之正方體之本體（1⑴过） 中’從本體（101a)之前面到整體之約1/3相當位置處由上往 下刻設橫跨長方向之全長之寬幅且深的溝（]〇lb)，並從本 體（l〇la)之後面至全體之約1/3相當位置處由上往下刻設 橫跨長度方向全長的傾斜溝⑽c、1〇lc)，其中該傾斜溝 (i〇jC、ioic)之下方朝前方傾斜，且具有較保持構件（ι〇2) 稍寬之寬度，並具有當插入保持構件（1〇2)時、能夠維持上 方朝後方傾斜姿勢之程度的深度。 在底座（101)之本體上面，係形成具有相同高度之左右 一對之平面部（103、103、104、104、105、105)，用以將 保持構件（102)以大約平躺之狀態予以載置，形成各平面部 (103、103、104、104、105、105)之構件之中間部位係以 較平面部（103、103、104、104、105、105)低之方式形成， 從而使所载置之保持構件（102)之安定性更佳，同時使安裝 於保持構件（102)之捲裝體（11〇)之表面不會接觸到各平面 部（103、103、104、104、105、105)之中間部位。然後， 在位於中央部之平面部（1〇4、1〇4)植立用以與保持構件 (102)卡合的銷針（1〇6、1〇6)。 覓度廣且深之溝（101 b)之中央部係設置成可使捲裝體 載置台（107)升降。捲裝體載置台（1〇7)係形成為約正方形， 317545 54 1360509 其兩端立設形成為板狀之捲裝體支持構件（108、1〇8)β捲 '裝體支持構件（108、108)之中間位置係立設有可升降地支 持的轴構件。 保持構件（102)係形成為U字狀之構件，可提供在中央 部安裝捲褒體（11〇)，在u字狀構件之兩端部〇〇2a、嶋） 中，在内側之相對面迴轉自如地樞接有用以嵌合捲裝體 (110)之軸構件（未圖示）的安裝軸（丨丨丨、112)。其中，安裝 鲁軸（111)係形成為可於軸方向移動，藉由將突出於端部（1 之外面之抓柄部分（1113)向外面拉，就可安裝或卸下捲裝 體(110)。 ^ 兩々而4 (1 02a、102b)之載置於底座側之面（下面），係穿 设有定位用孔（l〇2c、1〇2d)，用以插入設置在底座側之平 面部（104、1〇4)之銷針（1〇6、1〇6)。 又，在端部（1 〇2b)之載置於底座側之面的相反側之面 (上面），係透過彎曲狀板狀彈簧（115)以能夠於垂直於軸構 •件（113)之軸撓曲之方式突設有試料集積體保持構件 (114)’该试料集積體保持構件（114)係迴轉自如地保持用以 連結試料集積體（12)之基部的軸構件（113)。軸構件（】丨3)之 攸试料集積體連接側之端部到相反側之端部之附近為止之 表面，係形成有具有試料集積體（12)之進給螺距的雄螺紋 (II 3a)’其中該進給螺距係由刻設於試料集積體（12)之試料 載體捲裝用之螺旋溝以及捲裝於捲裝體（11〇)之試料载體 之間距之關係所決定。然後，在試料集積體保持構件（114) 之保持端，係設置有與軸構件（113)所設之雄螺紋（113幻相 317545 55 1360509 , 符合之雌螺紋部（l〗4a)。另外，在軸構件（113)之位於試料 集積體連接側之相反側的端部係設置有抓柄（n3b)，藉轉 動該抓柄（113b)，而按照預定間距從捲裝體（11〇)捲取試料 載體到試料集積體（12)。在形成有軸構件（11 3)之雄螺紋 (113a)之部分和抓柄（U3b)之間，係形成有較雄螺紋（n3a) 之底部之直徑小之圓棒部（113c)，從而能夠從設於試料集 積體保持構件（114)之保持端之側部側之開口部分（丨】41))插 鲁入至雌螺紋部（iHa)。 在捲裝體（110)_，在靠近安裝軸（U1、112)所嵌合之 軸構件之形成位置之中央部之兩端部，係穿設有能夠插入 捲裝體支持構件（108、108)且貫穿表裡兩面之長孔（1〗〇3、 110a)。形成於捲裝體（11〇)之v形溝（H6e、..I〗心）及孔 (116f、...iMf)以及軸構件等係按照第一實施形態相同情況 形成。 載置分配構件（17)用之載置架（12〇)係形成為角型環狀 •之框體，框體之中央部係形成可從上面插入分配構件（17) 之嵌入部（未圖示），並於一面側之兩側部分刻設有未貫穿 之長孔（未圖示），用以抵接於捲裝體支持構件（1〇8、1〇8) 之前端部以便能夠穩定予以支持。 如第22圖所示，將捲裝體（11〇)安裝於保持構件 (1〇2)，在捲裝體（no)之長孔（110a、11〇3)插穿捲裝體支持 構件（108、108)，並在底座（101)之銷針（1〇6、1〇幻嵌入保 持構件（102)之孔（1 〇2c、1 〇2d)，從而以大約水平狀將主' 構件（102)載置於底座（1〇1)上。 ' 317545 56 1360509 載置保持構件（102)之後，在捲裝體支持構件（108、108) 之前端，以覆蓋載置載置架（120)之長孔（ll〇a、ll〇a)之方 • 式設置載置架（120)，再於載置架（120)之嵌入部插入分配構 件（17)。然後’將分配構件（17)從上方壓入，從而使含有試 料之液體按裝預定排列狀附著在捲裝於捲裝體（1丨〇)之試 料載體上’之後’將分配構件（17)以左右相反之方式再度 插入蚁入部，將分配構件（17)壓入，就可在試料載體（I 〇a) 中已附著有各液體之中間位置再附著液體。 如第21圖所示，將液體附著於捲裝體（11〇)之兩面後， 卸下分配構件（17)及載置架（120)，從保持構件（1〇2)之孔 (102d ’ I02d)中拔出銷針（106、1〇6) ’並且自捲裝體支持構 件（108 ' 108)取il{捲裝體⑴〇)，再將保持構件（1()2)之未突 出試料集積體保持構件（114)之端部插入於傾斜溝（i〇ic、 中，使保持有已在試料載體附著有液體之捲褒體⑽) 的保持構件（102)以朝斜後方傾斜狀予以立設。Furthermore, the driving portion and the mounting table hanging member are concentrated on the right side of the base to cover the spring, and the spring device, the damper portion, and the lock structure are also read by the cover. The sample (four) device (4)) is composed of the following members as shown in Figs. 36 to 40; the base (7)), the front right side portion of the front surface is spaced apart, and the front shape is formed into a concave shape, and Two side walls (9la, 91b) are provided; the driving part (52) is installed between the side walls (Wa 9] b) to synchronize the sample assembly (12) and the package body (μ) The same % can make the β-type aggregate (] 2) move in the direction of the vehicle; the cover (9] 〇), is placed on the outer side of the two side walls (91a, 9) b), and covers the drive part and the bullet The t device (53) is configured to impart a magazine when the sample assembly (12) moves in the axial direction to facilitate linear movement; and the 11 mounting table (8) is inclined to the cooker (80) and can be moved toward or away from the side wall. The direction of the (9la9ib) is straight, the support table (55) is provided with a linear motion that can be moved linearly; and the mounting bracket (%) is attached. When the two are placed on the side wall on the left side of the front side (called the attachment (4), it is not installed or removed, and the mounting table (54) is prevented from moving in the axial direction to be engaged and fixed. = (91b) is provided with The mounting pin (5)e that faces the side end of the side end of the mounting table (10) and protrudes in the horizontal direction. The driving portion (52) includes a rotating shaft (52) having a W (10) The front end of the head (] 3) of the sample assembly (10), and 3]7545 48 1360509 = is movable in the direction of the axis; the guide axis is called when the axis direction has been completed: 2 = Qing to return to the original position , used to resist the rotation lock, rebound and retracted to return to the direction; the connection structure will be the suspect shaft (10)) and the guide is called the end of the outer cover (52a): two to connect, and also pull back The use of the gripper; the shaft side gear member ^) is composed of a bearing for imparting a rotational force to the rotating shaft (52b) while supporting the shift of the shaft direction; the driving side gear member with the one-way clutch is manually Giving a rotational force while transmitting the driving force to the rotating shaft, and the intermediate gear member (52h) The manner movable-side gear member (52f) and the drive-side gear member (52g) connecting shaft. In the rotating shaft (52b), a groove (52l) parallel to the shaft is engraved on the circumferential surface in a circumferentially divided manner, and is used to convert the rotational force of the shaft side gear member into a rotating shaft (52b) The pin of the previous force (not shown) is such that the inner circumference of the shaft side gear member (52f) protrudes toward the center side, and the front end portion of the pin is formed to be movably inserted into the groove (52i) in the axial direction. The length and thickness of the Lu. Further, in the drive side gear member (52g), a manual handle (57) that protrudes outside the T wall (91a) is fitted to the shaft end portion, and the side gear member is rotationally driven as the handle is rotated. 52g), thereby transmitting a rotational force from the drive side gear member (52g) to the shaft side gear member (52f) via the intermediate gear member (52h), and then transmitting the driving force to the rotary shaft (52b) by the shaft side gear member (52f) On the upper side of the yoke mounting platform (54), at the edge of the upper central portion of the side end portion of the left side position, a pivoting member (54a) is formed, which is inserted into the front end portion of the 317545 49 1360509 The hole (21j) of the side support member (8 le) of the cookware (80) is supported by 'a corner portion at the lower left end and a positioning member (54b) for preventing the cooker (2 turns) from slipping is protruded. Further, a corner member for the right lower end of the side support member (81f) of the cooker (80) is also provided with a positioning member (54c) for preventing the cooker from slipping. The mounting table hanging member (96) is provided with a curved member (96a) having a swingable shape around the rotating shaft (96b) on the side of the driving portion of the side wall (91b), and is provided with a through-side wall (9ib), and the end of the curved member (96a) opposite to the end of the hanging end and the action of the guide shaft (52c), and the lifting of the hanging member (96c), when the cooker is placed (54) When the side wall (9 lb) is approached, the curved member (96a) is moved toward the hanging side, and the side end of the back side (ie, the lower side) of the S-mounting table (54) is protruded. The stopper member (54e) is engaged and fixed to fix the cooker mounting table (54) to a position close to the side wall (91b). On the back side of the cooker mounting table (54), a spring device (53), a damper portion (58), and a latch mechanism portion (59) are provided, and a cover body (96d) covering these members is attached. . The spring device (53) comprises: a bracket (53a) for a spring device that is erected on the back side of the cooker mounting table (54), and a spool that is freely rotatable to the bracket (53a) (53b), and a spring winding piece (53c) that winds the reel (53b) while fixing its free end side to the front end of the guide shaft (52c). The damper portion (58) includes a damper bracket (58a) and a damper provided with a damper side gear (not shown) that is meshed with a damper gear (not shown) provided on the guide shaft (52c). Device (58c). Damping device (58) uses oil 317545 50 1360509 resistive rotary damping to prevent rapid movement. The components of the latch mechanism (59) include: the front end from the guide shaft (52c), the hanging member (59a) a locking member (59b) mounted on the bracket (58a) in a manner pivotable about the axis; and an upper end fixed to the cooker mounting table (54) and formed in a linearly movable manner while being locked The non-hanging end portion of the member (59b) is pressed to the unhooking side releasing member (59C). The fixing portion between the end portion of the guide shaft (52c) and the spring winding piece (53b) is called, When the lower end portion of the hanging member (59a) is engaged and fixed to the hanging side end portion of the locking member (59b), if the cooker mounting table (54) is moved toward the side wall (51b), the hanging is released. The stopper member (59c) presses the non-hanging end portion of the lock member (59b) to the unhooking side, and when the connection between the hook member (59a) and the lock member (59c) is released, With the spring thrust of the spring coil (53c), the guide shaft (52c) is oriented under the resistance of the damper device (58c) Moves in the direction of the side wall (5 1 a). The end portion is engaged with the head of the sample assembly φ (2) before the rotation axis (52b), and the joint member (92d) is pulled toward the end. On the outer side of the side wall (9ia), when the sample accumulation device (9G) can operate the g-state, the latch mechanism portion (10) acts to be engaged and fixed so as not to return to the original position, and when installed as an operable cookware After the state is released, when the rotation shaft (52b) is moved toward the inner surface of the side wall (51b) by the spring force of the spring winding piece (53c), the damper device (10) is given appropriate to the guide shaft (52e). Resistance to control the speed of movement '俾 so that it does not move impatiently. The money accumulation device (9〇) is shown in Figure 41 and Figure 42. I is mounted on the mounting table (54), and the front end portion of the pivoting member (54a) 317545 51 1360509 is inserted into the hole (81j) of the S-piece (80) for support, and the engaging hole-side protruding member (26) and The protruding portion of the engaging shaft-side protruding member (9) is a guide, and after the positioning member (54b, 54C) is positioned approximately and prevented from slipping, the E-mounting table (54) is moved toward the side wall (91b) of the front right side, and When moving to the pin insertion hole (81j), the locking mechanism portion (59) is released and fixed, and the pin (51e) is pressed by the stopper (7). The abutting end (25e) moves the abutting end (25e) of the stopper (25) of the connecting package body (76) toward the releasing engagement side, and releases the stopper and the package body (16). Between the two, the package body (10) is in a state in which the clamp (21) is freely rotatable about the shaft members (16c, 16c). At this time, before the pin (51e) is inserted into the hole (81j), the unwinding member (96c) of the mounting table hanging member (96) is moved to the unhooking side, and the curved member (96a) is pressed. The end 31 on the opposite side of the end side is suspended, thereby releasing the engagement between the hanging member (Me) provided on the back side of the dispensing table (54) and the hanging end of the curved member (96a). Stop) status. Then, the rotation shaft (52b) is moved toward the sample assembly (12) so that the front end portion is engaged with the head portion (13)' so that the rotational force can be transmitted to the sample assembly (12)' simultaneously with the guide shaft ( In the movement of 52c), the unhooking member (96c) of the mounting table hanging member (96) is moved in the hanging direction, and the hanging end of the curved member (96a) is engaged and fixed to the cooker mounting table ( 54) The hanging member (54e) on the back side, and the position of the cooker mounting table (54) is fixed. When the package body (76) is in the free state, when the handle (57) coupled to the drive side gear member (52g) is rotated, the drive side gear member (52g) is rotated and driven by the drive side gear member (52g) Through the intermediate gear member ^) 317545 52 1360509 shaft side gear member (52f). Thus, by rotating the gears, the head (13) that is engaged with the front end of the rotary shaft (52b) and the sample assembly (12) are rotated together, and the sample carrier is taken up from the package body (76). (10a), and since the latch mechanism portion (59) has been disengaged, the rotating shaft (52b) and the guide shaft (52c) can be slowly moved by the spring force of the spring winding piece (53e). The sample carrier (10a) is spirally wound in the direction away from the side wall (91b) and in the groove 2e) formed in the sample assembly (12). φ The method of manufacturing the sample assembly of the second embodiment can be carried out in the same manner as in the first embodiment until the sample suspension is attached to the package (76) provided on the article (80). In the order of the winding of the sample assembly (12), the mounting table hanging member (96) is interlocked with the operation of the rotating shaft (52b) and the guide shaft (52c). Although there are differences in the places where the engagement or the engagement is released, other operations can be performed in the same order as in the first embodiment, and therefore will not be described. In addition, the use of the sample assembly produced by the second embodiment is the same as that of the sample assembly 〇2) manufactured in the first embodiment. Therefore, the use (for example, storage reaction measurement) is also described in the first embodiment. The same applies to 'the description is omitted. In this way, even if the respective devices are changed, the sample assembly (12) can be made efficiently and accurately. Therefore, it is easier to use than the first embodiment, and a sample assembly having high efficiency and high precision can be obtained. ). 1·^ Implementation of a bear ^ A simple device having both a liquid dispensing device (40) and a sample accumulation device (50) As described in the third embodiment, the following description will be given. 337545 53 1360509 The liquid dispensing and accumulating device (100) is used as the base ((8)) of the liquid dispensing device and as the sample assembly (12) and the volume as shown in Figs. 43 and 44. The sample (16) is composed of a sample holding member (10). The base (101) is formed in the main body (1(1) over) in which the longitudinal direction is a lateral direction. From the front surface of the main body (101a) to about 1/3 of the whole position, the entire length of the long direction is engraved from the top to the bottom. A wide and deep groove (] 〇 lb), and from the back of the body (l〇la) to about 1/3 of the total position, the inclined groove (10) c, 1 横跨 across the length direction is engraved from the top to the bottom. Lc), wherein the inclined groove (i〇jC, iio) is inclined downward toward the front, and has a width slightly wider than the holding member (ι2), and has a capacity to be maintained when the holding member (1〇2) is inserted The depth to which the upper side is tilted toward the rear. On the body of the base (101), a pair of right and left flat portions (103, 103, 104, 104, 105, 105) having the same height are formed to hold the holding member (102) in a state of being lying flat. The intermediate portion of the member on which the flat portions (103, 103, 104, 104, 105, 105) are placed is formed to be lower than the flat portions (103, 103, 104, 104, 105, 105), thereby The stability of the holding member (102) is better, and the surface of the package (11) mounted on the holding member (102) does not contact the flat portions (103, 103, 104, 104, The middle part of 105, 105). Then, pins (1〇6, 1〇6) for engaging with the holding member (102) are formed in the flat portion (1〇4, 1〇4) located at the center portion. The central portion of the wide and deep groove (101b) is arranged to allow the package mounting table (107) to move up and down. The package mounting table (1〇7) is formed into a square shape, and 317545 54 1360509 is provided with a package-shaped support member (108, 1〇8) formed in a plate shape at both ends thereof. The middle member at 108) is provided with a shaft member that can be supported by the lift. The holding member (102) is formed into a U-shaped member, and the winding body (11〇) can be attached to the center portion, and the opposite sides of the inner side of the u-shaped member 〇〇2a, 嶋) A mounting shaft (丨丨丨, 112) for fitting a shaft member (not shown) of the package body (110) is rotatably pivoted. Wherein, the mounting shaft (111) is formed to be movable in the axial direction, and the package body (110) can be attached or detached by pulling the grip portion (1113) protruding outside the end portion (1) to the outside. ^. ^ Two and 4 (1 02a, 102b) placed on the side of the base (below), with positioning holes (l〇2c, 1〇2d) for insertion into the base side Pins (1〇6, 1〇6) of the flat portion (104, 1〇4). Also, on the opposite side (upper surface) of the end portion (1 〇 2b) placed on the base side, The sample assembly holding member (114) is protruded by a curved plate spring (115) so as to be perpendicular to the axis of the shaft member (113). The sample assembly holding member (114) is attached. The shaft member (113) for connecting the base of the sample assembly (12) is rotatably held, and the end portion of the shaft member (; 丨3) on the side of the connection side of the sample assembly is adjacent to the end portion on the opposite side. The surface is formed with a male thread (II 3a) having a feed pitch of the sample assembly (12), wherein the feed pitch is a sample carrier engraved on the sample assembly (12) The relationship between the spiral groove for mounting and the sample carrier wound on the package (11〇) is determined. Then, at the holding end of the sample assembly holding member (114), a shaft member (113) is provided. The male thread (113 phantom 317545 55 1360509 conforms to the female thread portion (l) 4a). Further, the end of the shaft member (113) on the side opposite to the side on which the sample assembly is connected is provided with a grip. (n3b), by rotating the grip (113b), the sample carrier is taken up from the package body (11〇) to the sample assembly (12) at a predetermined interval. The male thread (113a) in which the shaft member (113) is formed Between the portion and the grip (U3b), a round rod portion (113c) having a smaller diameter than the bottom of the male thread (n3a) is formed so as to be able to be provided from the holding end of the sample assembly holding member (114) The opening portion on the side of the side (丨) 41)) is inserted into the female thread portion (iHa). In the package body (110)_, the formation of the shaft member fitted to the mounting shaft (U1, 112) Both ends of the central portion of the position are inserted through the package supporting members (108, 108) and penetrate the surface The long hole of the surface (1〗 〇3, 110a). The v-shaped groove (H6e, ..I) and the hole (116f, ... iMf) and the shaft member formed in the package body (11〇) It is formed in the same manner as in the first embodiment. The mounting frame (12) for placing the distribution member (17) is formed into an angular ring-shaped frame, and the central portion of the frame is formed into a distribution member from above. (17) an insertion portion (not shown), and a long hole (not shown) that is not penetrated is formed on both side portions of the one surface side to abut against the package supporting member (1〇8, 1) 〇8) The front end so that it can be stably supported. As shown in Fig. 22, the package body (11〇) is attached to the holding member (1〇2), and the long hole (110a, 11〇3) of the package body (no) is inserted through the package supporting member ( 108, 108), and the pin (1〇6, 1〇 imaginary embedded in the holding member (102) (1 〇 2c, 1 〇 2d) of the base (101), so that the main 'member (about the horizontal) 102) placed on the base (1〇1). '317545 56 1360509 After placing the holding member (102), at the front end of the package supporting member (108, 108), to cover the mounting frame (120) The long hole (11〇a, ll〇a) is provided with the mounting frame (120), and then the distribution member (17) is inserted into the insertion portion of the mounting frame (120). Then the 'distributing member (17) Pressing in from above, so that the liquid containing the sample adheres to the sample carrier wound on the package (1) after being placed in a predetermined arrangement, and then the distribution member (17) is reinserted into the ant in the opposite direction. In the inlet portion, the dispensing member (17) is pressed in, and the liquid can be attached to the intermediate position where the liquid has adhered to the sample carrier (I 〇 a). As shown in Fig. 21, the liquid is attached to the liquid. After the two sides of the package body (11〇), the distribution member (17) and the mounting frame (120) are removed, and the pin (106, 1) is pulled out from the hole (102d ' I02d) of the holding member (1〇2). 〇6) 'and taking the il{roller (1)〇 from the package supporting member (108' 108)), and then holding the end of the unsupported sample assembly holding member (114) of the holding member (1()2) The holding member (102) inserted into the inclined groove (i) and holding the winding body (10) to which the liquid has adhered to the sample carrier is erected obliquely rearward.

糟由轉動軸構件⑴3)之抓柄⑴3b)，將捲裝於捲们 〇⑼之試料載體按照預定間距捲取在試料集積體（12)之才 =部（12a)°此時’捲裝體_係對應於試料載體之捲取 :=裝於捲裝體陶之試料載體持續地被拉_ =出試料載體時施加到試料载體之張 :⑴5),曲’從而把張力之變化克 淨 【圖式簡單說明】 #度 第1圖表示本發明$筮+案# 之4貫施形態令，捲裳有試料載 317545 57 U00509 之：料集積體收納在吸管狀態之局部剖面斜視圖。 圖 圖 弟2圖表不該捲裝有試料载體之試料集積體之斜視 〇 第3圖表示該捲裝有試料裁體之試料集積體之縱剖面 第4圖表示該試料集積體之擴大斜視圖。 態 第5圖表示該試料隼藉雕 〃積肢之核心部和頭部之分離狀 之擴大斜視圖。 視圖 圖 ° 圖 第6圖表示於該試料集積體嵌合有軸構件之狀態之斜 〇 第圖表示本土明之第一實施形態之捲裝體之斜視 第8圖表示本發明之第—實施形態之分配構件之斜視 ^ 9圖表示由下看該分配構件之狀態之斜視圖。 •帛10圖表不本發明之第一實施形態之試料集積用昆 具之斜視圖。 第Π圖表示組裝該試料集積用匣具過程中之狀態之 斜視圖。 第12圖表示正好在組裝該試料集積用匣具終了前由 下側看到情形之斜視圖。 ^ 第13圖表示該試料集積用匣具中試料集積體和捲裝 月豆間^立置關係及試料冑體之捲裝狀態之平面圖。 第14圖表示本發明之第一實施形態之點液裝置之斜 58 317545 ^^0509 視圖。 第1 5圖表示該點液裝置中，安裝匣具及分配構件狀態 之斜視圖。 第16圖表示本發明之第一實施形態之試料集積化裝 置之斜視圖。 第17圖表示該試料集積化裝置從背面側觀視之斜視 第18圖表示該試料集積化裝置中安裝試料 具之狀態之正面斜視圖 &第19圖表不於該試料集積化裝置中安裝有匣具之报 怨中’省略覆蓋件之斜視圖。 轉穿表示本發明之第—實施形態之試料集積體竣 轉裝置之概要，從右側觀視之斜視說明圖。 第21圖表示該試料集積體旋 視之斜視說明圖。 罝之概要，徒左侧觀 第22圖表不該試料集積 構件，試料集積體之狀態之斜視圖t配置"'裝有轴 第23圖表示本發明 _ — 體之試料集積體收納在吸管：：：施形態之捲裳有試料载 第24圖表示捲心之局部剖面斜視圖。 圖。有輯料載L集積趙之斜視 面圖第25圖表示捧“輯料載趙之試料集積體之縱到 第26圖表示、構件於該試料集積體之狀態之斜 3】7545 59 1360509 視圖。 第27圖表示本發明之第二實施形態之捲裝有試料 體之試料隼積體t # λ. 本槓粒之另—態樣被收納於吸管之狀態之局部剖 面斜視圖。 ° 第28圖表不捲裝有試料載體之試料集積體之另一雜 樣之斜視圖。 〜 第29圖表不捲裝有試料載體之試料集積體之另一雜 樣之縱剖面圖。 第3〇圖表示这試料集積體之擴大斜視圖。 第31圖表不該試料集積體之核心部及頭部之分離狀 怨之擴大斜視圖。 第32圖表不軸構件嵌著於該試料集積體之 能 之狀態之斜視圖。 心银 第33目表示本發明之第二實施㈣之捲裝體之斜視 圖。 第34圖表示本發明之第二實施形態之試料集積龍 具之斜視圖。 第35圖表示移除該試料集積用匣具之上蓋體 農中之狀態之斜視圖。 2 36圖表示本發明之第二實施形態之試料 置之斜視圖。 =37圖表示該試料集積化裝置移除覆蓋件之斜視圖。 弟38圖表示該試料集積化裝置移除覆蓋件而自背面 側觀視之斜視圖。 卞向自月面 317545 60 1360509 第39圖表不該試料集積化裝置移除覆蓋件及右側 壁，而自右側面觀視之斜視圖。 第40圖表示該試料集積化裝置取出試料集積用匣具 之斜視圖。 第41圖表不該試料集積化裝置安裝有匣具之狀態之 斜視圖。 第42圖表示該試料集積化裝置安裝有匣具並移向右 側之狀態之右側斜視圖。 第43圖表示本發明之第三實施形態中’使用點液及試 料集積化裝置進行試料集積化狀態之斜視圖。 第44圖表示使用該點液及試料集積化裝置進行點液 狀態之斜視圖。 第45圖表示於習知技術之吸管中收納試料集積體之 狀態之局部剖面斜視圖。 第46圖表示習知技術之點液裝置之斜視圖。 第47圖表示本發明之第二實施形態之試料集積體之 另—態樣之斜視圖。 第4 8圖表示該試料集積體之核心部及頭部之分離狀 態之擴大斜視圖。 【主要元件符號說明】 10 探針 10a 試料載體 11 吸管 12 試料集積體 12a 核心部 12c 把柄部 12e 溝 12q、 13a 肋部 61 317545 1360509 12p 中心定位部 12r 前端側輛部 • · 12s 前端侧段差部 12t 護手部 12u 段差部 13 頭部 14 轴構件 15 0形環 16、76 捲裝體 16c、76c 轴構件 16d、76d 切缺部 16e、116e V 形溝 16f、16i、76g ' 76j、U6f (細長）孔 16g、76k 掛止部 17 分配構件 鲁17b突出構件 17c 把手構件 18 組合溝 20、80 匣具 21、81匣具夾具 21a、81a 上蓋體 21b、81b下蓋體 21e' 21f' 81e、81f側面支持構件 21c、81c安裝孔 21h、21i、81h、81i、81j 孔（p< 口 22、 96 旋轉軸 25 止動器 25b 樞接部 25c 抵接端 26 卡合用孔突出構件 26a 車由孔 27 卡合用軸側突出構件 27a 轴 40 點液裝置 41 台座 41a 匣具載置部 41b 定位構件 41c 止動器 42 架台 42a 架台本體 42b 導執 43 移動台 317545 62 1360509 支持台 56 把手 58 栓鎖機構部 60 旋轉軸 62 驅動齒輪 64 乾電池 66 76e 板狀外周壁 91a 載置台掛止構件 96a 旋轉軸 96c 點液集積化兼用裝置 底座 101 43b 分配構件載置台 … 44、53 彈簧裝置 * 44b、53b 捲線筒 51 底座 51b 側壁 52 驅動部 52b 旋轉軸 52d 連結構件 * 52g驅動側齒輪構件 52h 中間齒輪構件 53 彈簧裝置 54a 樞接構件 54c 定位構件 55 57 * 59 61 63 65 76b ' 96 96b 100 101 43c 嵌入部 44a、53c 彈簀捲片 50、90 試料集積化裝置 51a 側壁 51 e 銷針 52a、91c、91d 蓋體 52c 導向轴 52e 把手 52f 軸側齒輪構件 52i ' 76f 溝 54 匣具載置台 54b 定位構件 載置台掛止構件 阻尼部 試料集積體旋轉裝置 齒輪 馬達 開關 、91b 側壁 曲尺狀構件 解除掛止構件 i 本體 317545 63 1360509 為By the grips (1) 3b) of the rotating shaft member (1) 3), the sample carriers wound on the rolls (9) are taken up at a predetermined pitch at the predetermined portion (12a) of the sample assembly (12). _ corresponds to the coiling of the sample carrier: = the sample carrier loaded in the package body is continuously pulled _ = the sheet applied to the sample carrier when the sample carrier is discharged: (1) 5), and the curve changes the tension [Simplified illustration of the drawing] #度图图1 shows the four-dimensional form of the invention of the invention , 案 案 , , 317 317 317 317 317 317 317 317 317 317 317 317 317 317 317 317 317 317 317 317 317 317 317 317 317 317 317 317 317 317 317 317 317 317 317 FIG. 2 is not a squint of the sample assembly in which the sample carrier is mounted. FIG. 3 is a longitudinal section showing the sample assembly in which the sample is mounted. FIG. 4 is an enlarged perspective view showing the sample assembly. . State FIG. 5 is an enlarged perspective view showing the separation of the core portion and the head portion of the sample by the engraving. FIG. 6 is a perspective view showing a state in which a shaft member is fitted to the sample assembly. FIG. 8 is a perspective view showing a package of the first embodiment of the present invention. FIG. 8 is a view showing the first embodiment of the present invention. The squint of the distribution member is shown in an oblique view of the state of the distribution member as viewed from below. The 帛10 diagram is not an oblique view of the sample assembly for the first embodiment of the present invention. The figure is a perspective view showing the state in which the cookware for assembling the sample is assembled. Fig. 12 is a perspective view showing the situation seen from the lower side just before the end of assembling the cookware for the sample accumulation. ^ Fig. 13 is a plan view showing the relationship between the sample aggregate and the packaged moon-shaped bean in the sample-accumulating cookware and the package state of the sample carcass. Fig. 14 is a view showing the oblique 58 317545 ^^0509 view of the liquid dispensing device of the first embodiment of the present invention. Fig. 15 is a perspective view showing the state in which the cookware and the distribution member are attached to the liquid dispensing device. Fig. 16 is a perspective view showing the sample accumulating device according to the first embodiment of the present invention. Fig. 17 is a perspective view showing the state in which the sample collection device is mounted in the sample collection device, and Fig. 18 is a perspective view showing the state in which the sample collection device is viewed from the back side. The swearing of the cookware 'omits the oblique view of the cover. The outline of the sample assembly twisting device of the first embodiment of the present invention is shown in a squint view from the right side. Fig. 21 is a perspective view showing the squint of the sample assembly.概要 概要 , , , 第 第 第 第 第 第 第 第 第 第 第 第 第 第 第 第 左侧 左侧 左侧 左侧 左侧 左侧 左侧 左侧 左侧 左侧 左侧 左侧 左侧 左侧 左侧 左侧 左侧 左侧 左侧 左侧 左侧 左侧 左侧 左侧 左侧 左侧 左侧 左侧 左侧 左侧 左侧 左侧 左侧 左侧 左侧 左侧 左侧:: The shape of the roll of the sample has a sample load. Figure 24 shows a partial cross-sectional oblique view of the core. Figure. Fig. 25 shows the slanted surface view of the material-accumulated L-accumulation Zhao. The figure shows the view of the sample of the sample collection of Zhao, which is shown in Fig. 26, and the state of the component in the sample assembly. 7545 59 1360509 view. Fig. 27 is a partial cross-sectional perspective view showing a state in which the sample sump of the sample according to the second embodiment of the present invention is loaded with a sample body t # λ. An oblique view of another sample of the sample assembly in which the sample carrier is not wound. ~ Figure 29 is a longitudinal sectional view of another sample of the sample assembly in which the sample carrier is not wound. Figure 3 shows the sample. An enlarged oblique view of the aggregate. The 31st chart is an enlarged oblique view of the separation of the core and the head of the sample assembly. The 32nd chart is an oblique view of the state in which the axis member is embedded in the energy of the sample pool. The billet of the second embodiment (four) of the present invention is a perspective view of the package of the second embodiment (four) of the present invention. Fig. 34 is a perspective view showing the sample stacking rig according to the second embodiment of the present invention. Concentrated cookware Fig. 36 is a perspective view showing the sample placed in the second embodiment of the present invention. Fig. 37 is a perspective view showing the sample removing device removing the cover member. Fig. 38 is a view showing the sample collecting device removed. Oblique view of the cover from the back side. 卞向自月面317545 60 1360509 The 39th chart does not require the sample accumulation device to remove the cover and the right side wall, and the oblique view from the right side view. An oblique view of the sample accumulating device for taking out the sample accumulating device. Fig. 41 is a perspective view showing a state in which the sample accumulating device is mounted with the cookware. Fig. 42 is a view showing the sample accumulating device with the cookware attached and moved Fig. 43 is a perspective view showing a state in which a sample is accumulated using a spot liquid and a sample accumulation device according to a third embodiment of the present invention. Fig. 44 is a view showing the use of the spot liquid and sample accumulation. Fig. 45 is a partial cross-sectional perspective view showing a state in which a sample assembly is accommodated in a straw of the prior art. Fig. 46 shows a point of the prior art. Fig. 47 is a perspective view showing another embodiment of the sample assembly of the second embodiment of the present invention. Fig. 48 is an enlarged squint showing the separated state of the core portion and the head of the sample assembly. Fig. [Explanation of main component symbols] 10 probe 10a sample carrier 11 pipette 12 sample assembly 12a core portion 12c handle portion 12e groove 12q, 13a rib 61 317545 1360509 12p center positioning portion 12r front end side portion • · 12s front end side Step portion 12t Hand guard portion 12u Step portion 13 Head portion 14 Shaft member 15 0-ring 16 and 76 Wrapped bodies 16c, 76c Shaft members 16d, 76d Shredded portions 16e, 116e V-shaped grooves 16f, 16i, 76g ' 76j, U6f (slim) hole 16g, 76k Hanging portion 17 Distribution member Lu 17b Projecting member 17c Handle member 18 Combination groove 20, 80 Cookware 21, 81 Cookware jig 21a, 81a Upper cover 21b, 81b Lower cover 21e' 21f' 81e, 81f side support members 21c, 81c mounting holes 21h, 21i, 81h, 81i, 81j holes (p< port 22, 96 rotating shaft 25 stopper 25b pivoting portion 25c abutting end 26 engaging hole protruding member 26a By hole 27 Engagement shaft side projecting member 27a Shaft 40 Pointing device 41 pedestal 41a Cooker mounting portion 41b Positioning member 41c Stopper 42 Mount 42a Rack body 42b Guide 43 Mobile station 317545 62 1360509 Support table 56 Handle 58 Latch mechanism 60 Rotary shaft 62 Drive gear 64 Dry battery 66 76e Plate-shaped outer peripheral wall 91a Mounting table hanging member 96a Rotating shaft 96c Point accumulating device base 101 43b Distribution member mounting table... 44, 53 Spring device * 44b, 53b Reel 51 Base 51b Side wall 52 Drive portion 52b Rotation shaft 52d Joint member* 52g Drive side gear member 52h Intermediate gear member 53 Spring device 54a Spring member 54c Positioning member 55 57 * 59 61 63 65 76b ' 96 96b 100 101 43c Embedding portion 44a, 53c magazine winding 50, 90 sample accumulation device 51a side wall 51 e pin 52a, 91c, 91d cover 52c guide shaft 52e handle 52f shaft side gear member 52i '76f groove 54 cooker mounting table 54b positioning member mounting table Stop member damping part sample accumulator rotating device gear motor switch, 91b side wall curved member unhanging I 317,545,631,360,509 body member is

101b (深）溝 101c 傾斜溝 102 保持構件 103、 104、105 平面 106 銷針 107 捲裝體載置台 108 捲裝體支持構件 111、 112 安裝軸 113 軸構件 113a 雄螺紋 113b 抓柄 113c 圓棒部 114 試料集積體保持構件 114a 雌螺紋 114b 開口部 115 板彈簧101b (deep) groove 101c inclined groove 102 holding member 103, 104, 105 plane 106 pin 107 package body mounting table 108 package supporting member 111, 112 mounting shaft 113 shaft member 113a male thread 113b gripping handle 113c round bar portion 114 sample assembly holding member 114a female thread 114b opening portion 115 leaf spring

64 31754564 317545

Claims (1)

100年10月13曰修正替換頁 十、申請專利範圍： 種5式料集積用匣具，其特徵為，將試料集積體及捲裝 體配置成，使試料載體從捲裝有該試料載體之該捲裝體 相對於該試料集積體恆常以一定角度反覆被抽出，同時 形成為可連接於一驅動裝置，該驅動裝置係施加使該試 料集積體及該捲裝體連動且同步的驅動力。 2.如申請專利範圍第1項之試料集積用匣具，其中，該試 料集積體係一體式地具備有： 以疋間距分離刻設螺旋狀溝並捲附試料載體於 該溝之核心部；以及 、在該核心部之前端，以可接近遠離之方式連接而用 以挾持上述試料載體之前端部的頭部。 3.如申請專利範圍第丨項之試料集積用匣具，其中，係將 該試料集積體做成，在上述核心部之後端部刻設〇形環 溝，並可藉由嵌入該0 %環溝之〇形環挾持上述試料 載體之後端部。 4. 如申請專利範圍第1項至第3項中任 匣具，其構成包括： 一項之試料集積用 將上述試料集積體沿著其形狀以可於長度方 轉之方式予以嵌裝之本體中央部；以及 使刻設在上述試料集積體上之試料載 大約平行於捲裝於上述捲裝體上之試料載體，而將上: 捲裝體以可旋轉之方式Μ樞接之—對側方支 ^ 317545(修正本) 65 1360509 第094136458號專利申請案 • 100年10月13曰修正替換頁 藉由該一對之側方支承部、以及將各側方支承部設 置於各端部的上述本體中央部而形成門形狀，並可使上 述試料載體能均一地從上述捲裝體捲裝到上述試料集 積體上。 5·如申明專利範圍第1項至第3項中任一項之試料集積用 匣具，其中，將用以使驅動軸能夠連接至上述試料集積 體的開口予以設置在本體中央部之試料集積體嵌裝部 之侧面，並將用以使同步於上述試料集積體之旋轉而旋 轉驅動之驅動軸連接於前述捲裝體的開口設置在上述 側方支承部之捲裝體樞接部之侧面，而形成為使上述試 料集積體和上述捲裝體可以連動。 6. —種點液裝置，其特徵為，具備有： 用以載置捲裝體之台座； 直立設置於該底座之一個架台； 一體設置在該架台上之導執； 依隨上述導軌之導引而上下移動之移動台；以及 a又置在該移動台上且形成有能裝卸自如地篏裝分 配構件之嵌合部的分配構件載置台； 其中，可使鼓裝在上述敌合部之分配構件下降到上 述捲裝體上，而將試料以預定之行列狀總體地附著在捲 裝於上述捲裝體之試料載體上。 7. 如申請專利範圍第6項之點液裝置，其中，在上述架台 座及上述移動台之間，係設置作用有將上述移動台恆常 向上方推壓之力的捲帶彈簧式彈性手段，當上述分配構 317545(修正本) 66 第094136458裝專利申請案 件不下陪肚边,、、厂u 1〇〇年1〇月13日修正替換頁' 部。㈣’耩由力將上料動 8 一種簡集積化裝置，其特徵為，具備有： 的試料隼:疋方向文裳有試料集積體及捲農體 之方:= 且形成為以能繞著軸方向旋轉自如 以移動^上述捲㈣，同時可向該捲裝體之轴方向予 移動的匣具載置台； 移動自如地支持該匿具載置台的台座； 之試==侧端，用以使上置台上 體和捲裝體連動地予以驅動旋轉之驅動部； 向予：移動述S具載置台上之試料集積體，同時向軸方 動之上述驅動部之旋轉轴. 及連接在該旋轉抽之端部而向轴方向移動之導軸；以 段。—在該_^時向—方向賦予拉力之彈性手 9.如申請專利範圍第8項之試料 彈性手段係為捲帶彈簧式彈性手'段。、“中，上述 1申請專利範圍第8項或第9項之試料集積 申，上述驅動部係設有藉由手動而旋轉驅動的=其 317545(修正本) 67October, October 2014 曰Revised replacement page X. Patent application scope: A type 5 material accumulation cookware, characterized in that the sample assembly and the package body are arranged such that the sample carrier is loaded from the sample carrier The package body is repeatedly drawn out at a certain angle with respect to the sample assembly, and is formed to be connectable to a driving device that applies a driving force that causes the sample assembly and the package to be linked and synchronized. . 2. The sample accumulating cooker according to the first aspect of the invention, wherein the sample accumulating system is integrally provided with: a spiral groove is separated and separated by a crucible pitch, and a sample carrier is wound around a core portion of the groove; At the front end of the core portion, the head portion of the front end portion of the sample carrier is held in a manner that can be accessed close to each other. 3. The cookware for sample collection according to the scope of the patent application, wherein the sample assembly is formed, a ring-shaped annular groove is engraved at the rear end of the core portion, and the 0% ring can be embedded by The ridge ring of the groove holds the rear end of the sample carrier. 4. In the case of any of the cookware items in items 1 to 3 of the patent application, the composition includes: a sample accumulation for embedding the sample assembly along its shape in a manner that can be rotated in a lengthwise manner a central portion; and the sample placed on the sample assembly is loaded approximately parallel to the sample carrier packaged on the package, and the upper: the package is pivotally connected to the opposite side Square branch ^ 317545 (amendment) 65 1360509 Patent application No. 094,136, 458, PCT/Aug. 13 曰 曰 替换 曰 曰 曰 曰 曰 曰 曰 曰 曰 曰 曰 曰 曰 曰 曰 曰 曰 曰 曰 曰 曰 曰 曰 曰 曰 曰 曰 曰 曰 曰 曰 曰 曰 曰 曰The center portion of the main body has a door shape, and the sample carrier can be uniformly wound from the package to the sample assembly. The sample accumulating cooker according to any one of the items 1 to 3, wherein the sample for integrating the drive shaft to the opening of the sample assembly is provided in the center of the body. a side surface of the body fitting portion, and an opening for connecting the drive shaft rotatably driven in synchronization with the rotation of the sample assembly to the package body, and is disposed at a side of the package body pivoting portion of the side support portion Further, it is formed such that the sample assembly and the package can be interlocked. 6. A liquid dispensing device, comprising: a pedestal on which a package body is placed; a gantry that is erected on the pedestal; a guide that is integrally disposed on the gantry; a mobile station that moves up and down; and a distribution member mounting table that is placed on the mobile station and that is detachably fitted with a fitting portion of the armoring member; wherein the drum is mounted in the enemy portion The dispensing member is lowered onto the package, and the sample is integrally attached to the sample carrier wound on the package in a predetermined array. 7. The liquid dispensing device of claim 6, wherein a tape spring-type elastic means for applying a force for pressing the moving table upward is provided between the pedestal and the moving table. When the above-mentioned distribution structure 317545 (amendment) 66 No. 094136458 patent application case is not accompanied by the belly, the factory u 1 year 1 month 13th revised the replacement page 'part. (4) '耩 耩 力 力 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 a cooker mounting table that can be moved in the axial direction to move the above-mentioned roll (4) and can be moved in the axial direction of the package; the pedestal of the detachable mounting table can be movably supported; a driving unit that drives and rotates the upper stage upper body and the package body; and: rotates the rotating shaft of the driving unit that moves to the axis while moving the sample assembly on the S-mounting stage; a guide shaft that rotates the end of the pump and moves in the axial direction; - Elastic hand giving tension to the direction in the direction of the _^ 9. The sample elastic material according to the scope of claim 8 is a coil spring type elastic hand segment. "In the sample collection of item 8 or item 9 of the above-mentioned application patent range, the above-mentioned driving unit is provided with a rotary drive by hand = 317545 (Revised) 67
TW94136458A 2005-10-19 2005-10-19 Cassette for assembling samples, spotting apparatu TWI360509B (en)

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TWI360509B true TWI360509B (en) 2012-03-21

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