TWI358264B - Processes for producing blood powder - Google Patents

Processes for producing blood powder Download PDF

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TWI358264B
TWI358264B TW98117108A TW98117108A TWI358264B TW I358264 B TWI358264 B TW I358264B TW 98117108 A TW98117108 A TW 98117108A TW 98117108 A TW98117108 A TW 98117108A TW I358264 B TWI358264 B TW I358264B
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blood
powder
bag
cold
sterilization
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TW98117108A
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Chinese (zh)
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TW201041523A (en
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Hsu Yin Kuo
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Hsu Yin Kuo
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々、發明說明: —— — — ———— —— ——一 —— ———— 一 【發明所屬之技術領域】 ——— 本發明係有關於-麵物|粉製造方法,尤指—種完 嫩峨蛋自綱細中變質之動 【先前技術】 ,物血液基本上是由許多優質蛋白質所構成,然而在 ί 2過程中動物的血液通常都直接浪費掉。因為血液中的蛋 質八分解的速度遠比其他蛋白質分解速度快得乡,且 j後之血液會發出難聞的血料,砂—般屠宰場會以 的>月水清洗屠宰動物後所留下之錢,將這續 不用制大量清水清洗,實在是—雙錄蛋㈣棄而 第4 始有,動物之血液製作成血粉,如美國 第’,725號專利’即是一種血粉之製造方法。其 3下:將血液輸人獅H巾—混合航藉以凝J ^ 狀ft;請。C之溫度乾燥成含水15%之血^^於=立 用,之血粉之主㈣途是作為複合肥料之 ί菌溫之統來麵蛋_,轉錢及有任何 亡述之方法雖然可將動物之血液製 作成食品級之血粉造福大眾,即為Si 失二 =:二缺 精&求精之目的’積極不斷的加^究改良並經常期5力' 1358264 I 試,,終於開發出本發明。 —---------- 本發明之主要目的,在於解決上述的問題而提供一種將 ^液中之優質蛋白質保存下來又能製作成食品級企粉之動 物血粉製造方法。 為達上述目的,本發明主要係包括下列流程: 收集j6l液; 真空冷凍乾燥; ^粉:將乾燥後之血塊研磨成粉末; 袋 =:將所製狀血粉依所需之重量或予以分裝成 滅菌 本發明之上述及其他目的與優點, 例之詳細·與關中,獲得深人了解。 ^用實知 同i本發明在某些另件上,或另件之安排上容許有所不 ‘圖中=¾例’則於本說明書中,予以詳細說明,並 【實施方式】 如第物ί粉犧方法,請參閱 .真*主要係包含有下舰程:收集血液》急速冷 處所二 之,於收集血要採取之行為。反 有必要流轉述如下: 絲狀錄。兹將所 收集血液 等兩種區分為屠宰採血與活體採血 臟穿刺等方式放血U 昏後’ _喉或心 丹以套上乾淨袋子之桶子收集血液。另,々, invention description: —————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————— - The movement of the tender quail eggs from the outline of the fine [previous technique], the blood of the object is basically composed of many high-quality proteins, but in the process of ί 2 the blood of the animal is usually directly wasted. Because the egg yolk in the blood decomposes much faster than other proteins, and the blood after j will emit unpleasant blood, the sand-like slaughterhouse will use the moon water to clean the slaughtered animals. The money left, this will continue without cleaning a large amount of water, it is really - double recorded eggs (four) abandoned and the fourth began, the animal's blood is made into blood, such as the US ', '725 patent' is a blood meal manufacturing method. 3 of them: the blood will be transferred to the lion H towel - a hybrid flight to condense J ^ ft; please. The temperature of C is dried to 15% of water. ^^============================================================================================ The blood of animals is made into food-grade blood powder for the benefit of the public, that is, Si loses two =: two lack of fine & the purpose of refinement 'actively improve the improvement and regular period 5 force ' 1358264 I test, and finally developed this invention. —---------- The main object of the present invention is to solve the above problems and to provide a method for producing animal blood powder which can preserve high-quality protein in liquid and can be made into food-grade powder. In order to achieve the above object, the present invention mainly comprises the following processes: collecting j6l liquid; vacuum freeze-drying; ^ powder: grinding the dried blood clot into a powder; bag =: preparing the prepared blood powder according to the required weight or dispensing The above and other objects and advantages of the present invention, as well as the details of the examples, are well understood. ^Using the actual knowledge and the invention in some parts, or the arrangement of the other parts to allow the 'not in the figure = 3⁄4 cases' is described in detail in this specification, and [implementation] ί powder sacrifice method, please refer to. True * mainly contains the following ship: collecting blood" rapid cold place two, in the collection of blood to take action. The necessary flow is described as follows: Silk record. The two types of blood collected are divided into slaughter and blood collection, blood collection by living body, and puncture of the blood. U stunned after the _ throat or heart Dan collects blood in a bucket with a clean bag. another,

Claims (1)

1358264 修正曰期 七、申麗: …—一 1、一種動物血粉製造方法,其係包含有下列流程:一 收集血液; 真空冷祕燥:首先將HTt以下之血液置於乾 上;將乾燥盤放置於-25Ϊ之冷凍櫃内凍結6_8小時 液完全處於結凍狀態;將真空冷凍乾燥機之乾燥 至-30 C ’在將乾燥盤連同血液至於乾燥室中再來纟士 1 2 時,以真空度約1-0.001 TORR之標準開始抽真空了拙直' 空的過程中其溫度設定須分為五個階段,其中, ^ -25°C、第二階段+40°C、第王階段+贼、第四階段+6g 以及第五階段+4(TC,每-階段所設定之時間約為6_8小 時,待血液溫度達到+3(TC並變為血塊時即完成乾燥之 業; 磨粉··將乾燥後之血塊研磨成粉末; 分裝.將所製成之血粉依所需之重量或劑量予以分 成袋;以及 < 滅菌。 2、依據申請專利範圍第丄項所述之動物血粉製造方法,其中, 該血液係指鴕鳥之血液,其收集方式係先將鴕鳥電昏再予 =倒吊,將胸前之毛拔除乾淨必要時加以局部消毒,再由 在、胸骨處以_插人心斷血並以套上乾淨袋子之桶子收 集血该。 3、 依據中請專利細第i項所述之動物血粉製造方法,其中, 磨ί之流程主要係利用磨粉機將乾燥後血塊研磨成粉末, 且整個研磨之過程巾磨粉機之溫度必須控制在+4()。〇以下。 4、 ,據申請專職圍第2項所述之動物血難造方法,其中, f空冷象,燥之步驟如下:將血液錄乾雜東結一抽 真空—乾燥完成—取出乾燥後之血液。 5據中請專纖11第2項所述之動物血粉製造方法,其中, 磨粉之流程主要係利用磨粉機將乾燥後血塊研磨成粉末, 8 1358264 修正£3 A . V®^0月 且整复研磨_靡中废粉機尤温度必須控制在^ 依據申吻專利範圍第1項所述之動物血粉製造方法,其中, 流程主要係利用磨粉機將乾燥後血塊研磨成粉末, 且正個^磨之過程中磨粉機之溫度必須控制在+4〇它以下。 、依據申請專利範圍第6項所述之動物血粉製造方法,其中, 該真空冷束乾燥之步驟首先將邮以下之 乾弹般 上二將乾燥盤放置於筑之冷_内;東結6_8小時乾= 液元卞處於結’東狀態;將真空冷;東乾燥機之乾燥室先預冷 至-3〇C,在將乾燥盤連同血液至於乾燥室中 • 時,以真空度約1-0·⑽TORR之標準開始抽;i、·:二i 空的過程中其溫度設定須分為五俯皆段,其 -25°^、第二階段+贼、第三階段+4〇ΐ、第四階段屮紙 1及f五階段+4〇〇C ’每一階段所設定之時間約為6-8小 待錢溫度達到+3代並變為血塊時即完成乾燥之作 某。 8、 依據申請專利範圍第!、2、3、4、5、6或7項所述 血粉?造方法’其中’該滅菌流程係採用高壓蒸 氣滅菌法,高壓蒸氣滅菌法主要係將裝滿血粉 梦 置於絲滅g射並緊_蓋,在壓力值Ιϋ 溫度為12rC的條件下維持15至20分鐘,待溫度盘壓 力自然下賴’再依序·驗_崎取域菌 之血粉,配合此滅菌法,前述分裝流程所 係為耐熱材質所製成。 匕· 9、 依據申請專利範圍第i、2、3、4、5、6或7項所述 2物ίίΐΐϊΐιί中,該滅_程係採用乾燥滅 卤法乾燥滅卤法主要係將裝滿血粉之包裝袋 中,以贿至_的條件下維持40^ 溫度降低後再取出滅菌完畢之血粉,配合此滅菌法,前 述分裝流賴選擇之包裝材係為耐崎制製成, 滅菌之前必須將分裝完成之包裝袋抽成真空’以免包 9 1358264 修正日 1 〇^4*、0月 期 袋中殘I义空氣因受熱膨脹而造成包裝袋爆裂。 10、 依據申請專利範圍第i、2、3、4、5、6或7項所 述之動物血粉製造方法,其中,該滅菌流程係採用加馬 射線照(γ-ray)射滅菌法,該滅菌法係將裝滿血粉之 包裝袋置於照射滅菌容器中,以1〇_3〇的kGy劑量照 射,且在加馬射線照射前後分別以分光光度計讀取光吸 收值,再以電腦程式計算出滅菌過程中血粉所吸收之劑 量值。 11、 依據申請專利範圍第1〇項所述之動物血粉製造方法,1358264 Amendment to the seventh period, Shen Li: ... -1, an animal blood powder manufacturing method, which includes the following processes: a collection of blood; vacuum cold secret: first put the blood below the HTt on the dry; Place in a freezer at -25°C. for 6-8 hours. The solution is completely frozen. Dry the vacuum freeze dryer to -30 C. Vacuum is applied to the drying tray together with the blood to the drying chamber. The temperature is about 1-0.001 TORR. The standard is set to vacuum. The temperature setting during the process is divided into five stages, of which ^ -25 ° C, the second stage +40 ° C, the king stage + thief 4th stage +6g and 5th stage +4 (TC, the time set in each stage is about 6_8 hours, when the blood temperature reaches +3 (the TC becomes a blood clot, the drying industry is completed; grinding powder·· The dried blood clot is ground into a powder; sub-packaging. The prepared blood powder is divided into bags according to the required weight or dosage; and < sterilization. 2. The method for producing animal blood powder according to the scope of the patent application. Where the blood is the ostrich Liquid, the way to collect it is to first faint the ostrich and then hang it upside down. Remove the hair from the chest and clean it if necessary. Then, sterilize the blood in the sternum and put it on the bucket with a clean bag. According to the method for manufacturing animal blood powder according to the above-mentioned patent fine item i, wherein the grinding process mainly uses a mill to grind the dried blood clot into a powder, and the entire grinding process is ground. The temperature of the machine must be controlled at +4(). 〇 below. 4. According to the method for applying the animal blood in the second paragraph of the full-time application, the steps of the air-cooling image are as follows: The knot is vacuumed - the drying is completed - the dried blood is taken out. 5 According to the method of manufacturing the animal blood powder according to the second item of the special fiber 11, wherein the grinding process mainly uses the mill to grind the dried blood clot into Powder, 8 1358264 Fixed £3 A. V®^0 month and re-grinding _ 靡 废 废 废 尤 尤 尤 尤 尤 尤 尤 尤 尤 尤 尤 尤 依据 依据 依据 依据 依据 依据 依据 依据 依据 依据 依据 依据 依据 依据 依据 依据 动物 动物 动物 动物 动物 动物 动物 动物 动物 动物 动物Using a mill to dry The blood clot is ground into a powder, and the temperature of the mill must be controlled below +4 〇 in the process of grinding. The method for producing animal blood powder according to claim 6, wherein the vacuum cold beam The drying step is first placed on the dry bomb below the post. The dry tray is placed in the cold _ inside; the east knot is 6_8 hours dry = the liquid element 卞 is in the knot 'east state; the vacuum is cold; the drying chamber of the east dryer is first Pre-cooling to -3 〇C, when the drying tray is placed in the drying chamber together with the blood, the vacuum is about 1-0·(10)TORR. The temperature setting must be divided during the process of i, ·: two i empty For each of the five stages, the time set in each stage of -25 ° ^, second stage + thief, third stage + 4 〇ΐ, fourth stage 屮 paper 1 and f five stage + 4 〇〇 C ' For the 6-8 small waiting for the temperature to reach +3 generations and become a blood clot, the drying is done. 8, according to the scope of application for patents! , 2, 3, 4, 5, 6 or 7 of the blood meal manufacturing method 'where 'the sterilization process is the use of high pressure steam sterilization method, the high pressure steam sterilization method is mainly to fill the blood powder dream placed in the silk and kill Tight_cover, under the condition of pressure value Ιϋ temperature of 12rC for 15 to 20 minutes, until the pressure of the temperature plate is naturally lower than the blood powder of the bacteria in the order, the sterilization method, the above-mentioned packaging process Made of heat-resistant material.匕·9, according to the scope of the patent application scope i, 2, 3, 4, 5, 6 or 7 2 ίίΐΐϊΐιί, the _ _ _ system using dry halogen method dry halogen method is mainly filled with blood meal In the packaging bag, the temperature is lowered after the temperature is lowered by 40^, and then the sterilized blood powder is taken out. According to the sterilization method, the packaging material selected by the above-mentioned packaging is made of Nasaki, and must be prepared before sterilization. The packaged bag is vacuumed to avoid the package 1 9358264 correction day 1 〇 ^ 4 *, the zero-day bag in the 0-month bag is caused by thermal expansion and the bag bursts. 10. The method for producing animal blood powder according to the invention of claim 1, wherein the sterilization process is a gamma-ray sterilization method. In the sterilization method, the package filled with blood powder is placed in an irradiation sterilization container, and is irradiated with a dose of kGy of 1 〇 3 ,, and the light absorption value is read by a spectrophotometer before and after the addition of the gamma ray, and then the computer program is used. Calculate the dose value absorbed by the blood meal during sterilization. 11. The method for producing animal blood powder according to the first aspect of the patent application scope, 其中,該加馬射線可由60C〇、137Cs或其他放射性物質 產生。 12、依據申請專利範圍第1、2、3、4、5、6或7項所 1之動物血粉製造方法進一步包含有一急速冷凍流 私,其主要將收集好血液血袋立即放入冷凍庫中,令血 液中之蛋白質開始分解以前即進入冷床狀能。 1 3、=巾請專利範圍第8項所述之動物血粉J造方法進一 =含ΐ一急速冷;東流程’其主要將收集好血液血袋立Wherein, the gamma ray can be produced by 60C 〇, 137Cs or other radioactive materials. 12. The animal blood powder manufacturing method according to claim 1, 2, 3, 4, 5, 6 or 7 of the patent application further comprises a rapid freezing flow privately, which mainly collects the blood blood bag and immediately puts it into the freezer. Let the protein in the blood begin to decompose before entering the cold bed. 1 3, = towel, please refer to the animal blood meal J method described in item 8 of the patent scope. 1. Including the rapid cooling of the cockroach; the east process ‘the main will collect the blood blood bag =ίί庫中’令血液中之蛋白質開始分解以前即進 入冷凍狀態。= ίί 库 ’ 令 令 令 令 令 令 令 令 令 令 令 令 令 ’ ’ ’ ’ 專ί範圍第9項所述之動物血粉製造方法進-ϋΐ冷;東流程’其主要將收集好血液血袋立 入冷^ί令錢中之蛋白制始分解以前即進 利ί圍第1 ◦項所述之動物血粉製造方法進 立冷歧程,其主要將收集好血液血袋 進入冷束。令血液中之蛋白質開始分解以前即 立即放入冷撕,‘中 1358264 修正曰期 進A冷魏態。 1 7、=碼物,梅術顺程:… 喷霧=内先Ϊ軟管接至欲乾燥之 現;該蠕動幫浦之送液速=4至的樣品出 °c ^ a»10 2〇 I 80 〇.6KG/cm2 ; 心乾展工風里從〇·3至 分裝袋將:Ϊ成之血粉依所需之重量或劑量予以分裝成 滅菌。 18、^2S5=i7項所述之動物血粉製造方法’ 電昏再丨”之血液,其收集方式係先將敏鳥 I: =2胸前之毛拔除乾淨必要時加以局: 袋子之桶子插入心臟放血並以套上乾淨 19 項所述之動物血粉製造方法, 2 0 翻職風分離器讓乾_試^降:水 出—完成絲、粉末狀職品出現。 =^_=17'18或19項所述之動物血 t二iiti _係將裝滿血粉之包裝袋置於高 緊嶋蓋,在壓力值u_m2且溫度為 下险德、持15至20分鐘,待溫度與壓力自然 下降後’再依序開啟茂壓閱與銷蓋取出滅菌完畢之血 11 1358264 • 修正曰期 、年、<月\沾 粉二配会此滅菌灰―’前述分裝流程所選探之包裝材係為 耐熱材質所製成。 ~ 21、依據申請專利範圍第17、18或19項所述之動物血 粉製造方法,其中,該滅菌流程係採用乾燥滅菌法,乾 燥滅菌法主要係將裝滿血粉之包裝袋置於烤箱中,以 120°C至180°C的條件下維持40至120分鐘,待溫度降 低後再取出滅菌完畢之血粉,配合此滅菌法,前述分裝 流程所選擇之包裝材係為耐熱材質所製成,且在滅菌^ 前必須將分裝完成之包裝袋抽成真空,以免包裝袋中殘The animal blood meal manufacturing method described in item 9 of the special range is in the cold process; the east process is mainly to collect the blood blood bag and set it into the cold, and the protein in the money is decomposed and the first step is to enter the profit. The method for producing animal blood powder according to the item enters a cold fraction, which mainly collects blood blood bags into cold bundles. Immediately before the protein in the blood begins to decompose, it is placed in cold tearing, ‘中 1358264 修正曰期入入A cold Wei state. 1 7、=码物,梅术顺程:... Spray=The inner first hose is connected to the dry one; the creeping pump's liquid delivery speed=4 to the sample out°c ^ a»10 2〇 I 80 〇.6KG/cm2 ; From the 〇·3 to the sub-package in the heart-drying work style: the blood powder of Ϊ成 is divided into sterilized according to the required weight or dosage. 18, ^2S5 = i7 item of animal blood production method 'electric fainting and then sputum' of blood, the collection method is to first remove the sensitive bird I: = 2 chest before cleaning, if necessary, the bureau: bag of bucket Insert the heart to bleed and put on the method of making the animal blood powder described in item 19, 2 Turn the wind separator to let dry _ test ^ drop: water out - complete silk, powdery product appears. =^_=17' The animal blood t2 iiti _ according to item 18 or 19 is placed in a high-tightness cap with a blood-filled bag at a pressure value of u_m2 and at a temperature of 15 to 20 minutes, until the temperature and pressure are natural. After the decline, 'restart the micro-pressure reading and pin cover to remove the sterilized blood 11 1358264 • Correct the flood season, year, < month\drink powder two match this sterilized ash-'the packaging of the above-mentioned dispensing process The material is made of a heat-resistant material. The method for manufacturing animal blood powder according to claim 17, 18 or 19, wherein the sterilization process is a dry sterilization method, and the dry sterilization method is mainly filled. The blood powder bag is placed in the oven at 120 ° C to 180 ° C Hold the sterilized blood powder for 40 to 120 minutes, and after the temperature is lowered, the packaging material selected by the above-mentioned dispensing process is made of heat-resistant material, and must be finished before being sterilized. The bag is vacuumed to avoid disability in the bag 留之空氣因受熱膨脹而造成包裝袋爆裂。 2 2、依據申請專利範圍第17、18或19項所述之動物血 粉製造方法,其中,該滅菌流程係採用加馬射線照(丨 -ray)射滅函法,該滅菌法係將褒滿血粉之包裝袋置於 照射滅菌士器中’以1〇_3〇的kGy劑量照射,且在加馬 射線照射,後分別以分光光度計讀取光吸收值,再以電 月®程式s十算出滅菌過程中血粉所吸收之劑量值。 2 3、依據”專利範圍第2 2項所述之動物血粉製造方法, 其中’該加馬射線可由60C〇、137Cs或其他放射性物 產生。 、The air left in the air caused the package to burst due to thermal expansion. 2, according to the method for manufacturing animal blood powder according to claim 17, 18 or 19, wherein the sterilization process is performed by a gamma-ray method, and the sterilization method is full. The blood powder packaging bag is placed in the irradiation sterilizer, and is irradiated with a dose of kGy of 1 〇 3 ,, and after the gamma ray irradiation, the light absorption value is read by a spectrophotometer, and then the electricity month is used. Calculate the dose value absorbed by the blood meal during the sterilization process. 2. The method of producing animal blood meal according to the above-mentioned patent scope, wherein the addition of the horse can be produced by 60C 137, 137Cs or other radioactive materials. 2 4、依ΐ申請專利範圍第17、18或19項所述之動物血 粉製造方法進-步包含有—急速冷綠程,其主要將收 集好血液血袋立即放入冷凍庫中,令血 始分解以前即進入冷凍狀態。 赏貝開 2 5 ^據申請專利範圍第2 0項所述之動物血㈣造方法進 含ί —急速冷;東流程’其主要將收集好血液血袋 料,令血射之蛋白質卿分解以前即 2 6、第2 i韻述之祕血㈣造方法進 二急速冷/東流程,其主要將收集好血液血袋 Ρ放入冷雜中,令血液中之蛋白質開始分解以前即 122 4. The animal blood powder manufacturing method according to Item 17, 18 or 19 of the application patent scope further includes a rapid cold green process, which mainly collects the blood blood bag and immediately puts it into the freezer, so that the blood begins. It is frozen before it is decomposed.赏贝开2 5 ^ According to the application of patent scope 20th of the animal blood (four) method of production into ί - rapid cold; East process 'it will mainly collect blood blood bag material, so that the blood of the protein That is, 2 6th, the 2nd rhyme of the secret blood (four) method of entering the second rapid cold / east process, which mainly collects the blood blood bag into the cold, so that the protein in the blood begins to decompose before 12 2 7 進么冷魏1。——— 、依圍第2 2項所造方法進 ^冷=⑽_自細分解以前即 修正日期 2 8、=中請專利範圍第2 7項所述之動物血粉製造方法進 一步包含有-急速冷m其主絲錢好血液血袋 立即放入冷凍庫中,令血液中之蛋白質開始分解以前即 進入冷凍狀態。 、 13 1-35*8264 修正曰期 嘀 '>g 八、圖式:2 7 Entering the cold Wei 1. ———、, according to the method of the second item, the method of the method of the second and second paragraphs of the method of the invention of the method of the invention of the method of the invention of the method of the invention Cold m, the blood money bag of the main silk money is immediately put into the freezer, so that the protein in the blood begins to decompose before entering the frozen state. , 13 1-35*8264 Revision period 嘀 '>g VIII, schema: 第一圖 \φ 1358264First picture \φ 1358264 First
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US11634257B2 (en) 2017-10-09 2023-04-25 Terumo Bct Biotechnologies, Llc Lyophilization container and method of using same

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US11634257B2 (en) 2017-10-09 2023-04-25 Terumo Bct Biotechnologies, Llc Lyophilization container and method of using same
US11604026B2 (en) 2019-03-14 2023-03-14 Terumo Bct Biotechnologies, Llc Lyophilization loading tray assembly and system
US11609043B2 (en) 2019-03-14 2023-03-21 Terumo Bct Biotechnologies, Llc Lyophilization container fill fixture, system and method of use
US11609042B2 (en) 2019-03-14 2023-03-21 Terumo Bct Biotechnologies, Llc Multi-part lyophilization container and method of use
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