TWI345469B - Method for absorbing carbon dioxide through skin and mucosa - Google Patents

Description

1345469 V. INSTRUCTION DESCRIPTION OF THE INVENTION (1) 1. Technical Field of the Invention The present invention relates to a transdermal mucosal absorption method capable of promoting carbon dioxide and a cosmetic method using the same. 2. [Prior Art] It has been known that carbonated springs have effects on beauty and other skin aspects. This kind of beauty and other effects are obtained because the carbon dioxide element is percutaneously absorbed by the human body through the dry film. In order to achieve such effects, the development of various artificial carbonated bathing agents in the industry is available to the market, and everyone in the family can easily purchase and use them. However, due to the low concentration of carbonic acid gas (please refer to the "Research on Artificial Carbonated Springs" published by Wan Xiulian et al. (third report): Basic issues concerning the modulation of artificial carbonated springs and the influence of the concentration of scattered carbon dioxide gas" Wenqiwu Medical Doctor 4 8 : 7 9 - 8 5,1 9 8 5 ), in fact, it is difficult to obtain a very ideal cosmetic and therapeutic effect is the current state. In Sakamoto Kaiping 8 - 2 8 1 0 8 7 In the patent publication, a desktop type carbonated spring manufacturing apparatus has been disclosed, and it has been reported that a carbonated spring manufactured by the apparatus has an effect of improving skin inflammation such as acne (formal spring pox). However, such a carbonated spring has a manufacturing cost, and In order to obtain a very effective effect, it is necessary to add a large amount of water and carbon dioxide gas (carbonic acid gas), etc. Further, in Japanese Patent Laid-Open Publication No. 2000-301, which discloses the percutaneous transmucosal absorption of carbon dioxide. Composition, this bulletin also reveals the transmucosal absorption of carbon dioxide through the skin such as vesicular rash (Hong Kong feet), insect bites, atopic dermatitis, plaque eczema, dry skin, seborrheic eczema, urticaria, Itching treatment, housewife Treatment, youth vulgaris epidemic, pus disease therapy, hand blister inflammation, carbuncles, boils son, cellulitis, impetigo disease, psoriasis, ichthyosis addiction, palm lame keratosis,

1345469 V. Description of invention (2)

Mossy, pityriasis, trauma, scald, chapped, ulcerated, frostbite, etc.; or itch, acne, trauma, burns, keratitis, stomatitis, skin ulcers, dryness caused by skin and mucous membrane disorders Skin and mucous membrane damage such as ulceration, frostbite, and loam; transplantation of skin slices, membranes, etc.; dental caries, dentures, dentures, dentures, black teeth, stomatitis, etc.; Skin ulcers or cold sensation, paralysis caused by peripheral circulatory disorders such as occlusive thromboangiitis, obliterative atherosclerosis, diabetic peripheral circulatory disorders, and lower extremity venous tumors; neuralgia, polyneuritis, and simon SMON) neurological disorders such as diseases; chronic arthritis; neck and shoulder syndrome, muscle pain, joint pain, low back pain and other skeletal disorders; dry colic, corns, moles, ichthyosis, palmoplantar keratosis, moss, Keratosis abnormalities such as sputum; purulent skin disorders such as acne vulgaris, pus, sputum, sputum, sputum, cellulitis, pustules, purulent eczema; The hair regeneration suppression hair (hair treatment free); cosmetically problem freckles, rough skin, skin dark attenuation of skin elasticity and color, hair color, skin and hair of the recession and the like, and effective full discussion of the local Yutaka.

However, when the composition is used, since the percutaneous transmucosal absorption of carbon dioxide is not large, in order to obtain an effective cosmetic or therapeutic effect, it is necessary to continuously use it for a long period of time, and the effect is not so obvious. The present invention has been developed in view of the above circumstances, and it is therefore an object of the present invention to provide a simple and effective carbon dioxide transdermal process which can promote the transmucosal absorption of carbon dioxide through the skin and achieve a very effective cosmetic and therapeutic effect. Mucosal absorption method and method of using the same in beauty.

Page 5 1345469 V. OBJECTS OF THE INVENTION (3) III. [Summary of the Invention] The present inventors have diligently researched and developed a technique capable of obtaining a cosmetic effect such as carbon dioxide absorbed by the transmucosal transmucosal mucosa simply and strongly, and found that Before the administration of carbon dioxide to the skin and mucous membranes, or when administered, the carbon dioxide-absorbing auxiliary material selected from the group consisting of water, fat, and an organic solvent is used as an essential component for moisturizing the skin mucosa or When the treatment of reducing the skin and mucous membranes is increased, the skin can absorb the percutaneous transmucosal absorption of carbon dioxide, thereby obtaining a stronger and more effective beauty and treatment than the use of a carbonated spring or a carbon dioxide-containing external preparation for the administration of carbon dioxide alone. Effect, 遂 completed the present invention. In other words, the percutaneous transmucosal absorption method of carbon dioxide of the present invention is a method for promoting percutaneous transmucosal absorption of carbon dioxide administered to the skin and mucous membranes, which is characterized in that the skin and mucous membranes are applied before or during administration of the above carbon dioxide. It is a treatment which can promote and increase the absorption amount of carbon dioxide percutaneous transmucosal (application patent item 1). According to the above configuration, before the administration of carbon dioxide or during administration, since the application to the skin and mucous membrane can promote and increase the absorption of carbon dioxide percutaneous transmucosal, it is compared with the case where the carbon dioxide-containing external preparation or carbonated spring is generally administered alone. It can obtain a strong and effective cosmetic and skin treatment effect caused by percutaneous transmucosal absorption of carbon dioxide. The term "carbon dioxide" as used herein refers to carbon dioxide gas and carbon dioxide gas dissolved in a solvent such as water. The treatment for the skin and mucous membranes is carried out by using a solution for carbon dioxide dissolution selected from at least one selected from the group consisting of water, oils and fats and organic solvents.

J345469

It is indicated that the carbon dioxide absorption of the component (4) is sufficient for the treatment of skin adhesion (item 2 of the patent application). It retains the function of water and oil lipids. Since the carbon dioxide is percutaneous ^ = ^«七·一 /1_ _2J_ Α α · · 一 - 6 It is known that carbon dioxide can be absorbed through the skin and mucous membranes, but its absorption is very small according to the general method. When carbon dioxide is absorbed through the transmucosal mucosa, it is usually necessary to first contain a certain amount of water or lipid through the stratum corneum 'the outermost horny skin of the skin and mucous membranes', but the content of the carbon dioxide is less than that of the stratum corneum (inner). 'And keratinocytes are not living cells, so no, Ά 一 一 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 For example, a method of immersing a portion where the effect of carbon dioxide is desired in water, spraying a water mist on the portion with a sprayer, or the like may be employed. A wet towel or a face paper may also be used: a cover is provided in the portion. The method 'if this method does not drip or flow down, it is easier to use and less necessary to select the positive part. Also 'use of water to promote the absorption of water' eight carbon dioxide is absorbed by the stratum corneum a rate control + (rate Determining step), want to increase the amount of carbon dioxide absorbed by the treatment of > carbon oxide treatment and cosmetic effect 'have to be obtained: the state of easy to absorb carbon dioxide ..., will be selected from energy One or more sputum osmotic solution solutions of a group consisting of water, lipids and an organic solvent may be applied to the stratum corneum. Specifically, before the administration or the administration, the solution for dissolving carbon dioxide is used. The essential component > oxidized carbon absorption auxiliary material 'is wetted by the carbon dioxide dissolution liquid, that is, f: the so-called carbon dioxide absorption auxiliary material means liquid-containing

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Page 7 1345469 V. Description of the invention (5) It is better to prepare the appropriate original material and material for the stratum corneum. It is better to give as much as possible to the skin and mucous membranes and the skin condition of the subject. The lipid (fat) is applied to a method in which the keratin is directly applied to the skin film and then attached to the skin mucosa. One or more of the combined neutral fat and complex lipid. Further, the lipid was dissolved and used. It is best to use the raw materials first to make carbon dioxide absorption and to give the skin and mucous membranes to absorb the lipid method or the skin condition of the subject, and to prevent the skin as high as possible. The stratum corneum absorbs the organic solvent medium and directly coats the skin and mucous membrane of the skin and mucous membranes. The method, the method of organically dissolving the mucosa, and the like. One or more of organic solvents are used. Further, the absorption ability of the stratum corneum may be adapted. The degree 'because of the absorption method used does not cause the skin and mucous membranes. In addition, it is of course possible to apply water to the skin in the case of water, if necessary, and other suitable oxidized carbon absorption auxiliary materials, although depending on the application side. The method of using the same method, for example, by using a lipid method, or impregnating a lipid with a lipid such as gauze, a fatty acid, a glycerol and a fatty acid phosphate, cholesterol, etc., can be used, and it can be used as a solid. Water or an organic solvent can be applied to the mucous membrane of the skin after promoting the entry of the lipid into the appropriate material of the stratum corneum. The degree of the amount, although the absorption is different, but in the method of not causing the barrier of the skin and mucous membranes, for example, an organic solvent method can be used, and the organic solvent is sprayed on the gauze by a sprayer, and then applied to the skin such as ethanol. An alcohol such as butanol may be mixed with the organic solvent to promote absorption of the amount of the organic solvent or the skin state of the subject, but it is preferable as far as possible. , a mixture of lipids and organic solvents. The raw materials are mixed.

Page 8 1345469 V. Description of the Invention (6) In this manner, a carbon dioxide-containing external preparation containing at least one of a group consisting of water, a lipid, and an organic solvent is used as an essential component to moisturize the skin and mucous membranes. When carbon dioxide is applied to the skin and mucous membranes using carbon dioxide or a carbon dioxide-containing external preparation, carbon dioxide can be easily absorbed into the subcutaneous tissue, and a strong and effective therapeutic and cosmetic effect can be easily obtained. The above treatment is preferably performed to reduce the temperature of the skin and mucous membranes.

(Applicant's patent scope item 3). Carbon dioxide can be absorbed by body fluids or the like dissolved in the skin and mucous membranes, and the lower the temperature of the solvent, the more the amount of carbon dioxide is dissolved. Therefore, in order to enhance the percutaneous transmucosal absorption capacity of carbon dioxide, the therapeutic and cosmetic effects achieved by the transdermal absorption of carbon dioxide by the skin can be improved, and the temperature of the skin and mucous membranes can be lowered. The method for lowering the temperature of the skin and mucous membrane is not particularly limited. Generally, a cold application method such as ice or a frozen cold-preserving agent attached to the skin and mucous membrane may be used, and a method of blowing cold air or rubbing an evaporative liquid such as alcohol may be used, and taken away during evaporation. A method of reducing the temperature of the skin and mucous membranes by heat of vaporization of the skin and mucous membranes. Although the degree of cooling of the skin and mucous membranes varies depending on the subject's constitution or room temperature, it is preferable to minimize the damage caused by the skin and mucous membranes.

When a gaseous carbon dioxide or a carbon dioxide-containing external preparation is applied to the skin mucosa set to a low temperature as described above to give carbon dioxide, a better cosmetic and therapeutic effect can be obtained as compared with the case of applying a gaseous carbon dioxide or a carbon dioxide-containing external preparation alone. It is preferable that the above-mentioned carbon dioxide absorbing auxiliary material has a temperature lower than that of the skin mucosa (article 4 of the patent application). At this time, carbon dioxide can be used

Page 9 1345469 V. INSTRUCTIONS (7) -- The increase in the amount of carbon dioxide absorbed by the absorption of auxiliary materials and the increase in the amount of carbon dioxide absorbed by reducing the temperature of the skin and mucous membranes are complementary and simple. It is better to obtain a better cosmetic and therapeutic effect. The above-mentioned carbon dioxide absorbing auxiliary material is preferably a carbon dioxide absorption auxiliary liquid containing the above-mentioned carbon dioxide dissolution liquid (the fifth scope of the patent application). In this case, a desired effect can be obtained by using a small amount of carbon dioxide absorption auxiliary liquid, and thus it is advantageous in terms of cost. Further, the carbon dioxide absorption-assisted solution may be composed of only a solution for dissolving carbon dioxide, or a mixture of other materials may be added to the solution. It is preferable that the carbon dioxide absorption auxiliary material is made of a carbon dioxide absorption auxiliary containing the above-mentioned carbon dioxide dissolution liquid (the sixth scope of the patent application). In this case, there is an advantage that the carbon dioxide dissolution liquid can be continuously supplied. The carbon dioxide absorption auxiliary body as used herein refers to a molded body having a predetermined shape containing the above-described carbon dioxide dissolving liquid, and generally has, for example, a hydrous molecular film. The water-containing polymer membrane is easy to manage and the impregnated water is not easily leaked. As long as it is applied to the skin and mucous membranes, it can continuously supply water to the stratum corneum. Therefore, it is quite convenient to use, and the water-containing polymer pellet itself has carbon dioxide gas. Through the function of the membrane, it can compensate for the low dioxo carbon absorption of the stratum corneum. The water content of the aqueous polymer membrane is preferably as large as possible, and is usually more than 15% by weight, more preferably 3 parts by weight, and more than 5 parts by weight, based on the total composition. The upper limit of the water content varies depending on the water, but the water content is preferably as high as the physical properties such as the flexibility of the aqueous polymer film are not affected. x, after using cooled

1345469 V. INSTRUCTIONS (8) Aqueous polymer membrane gas not only moisturizes the skin and mucous membranes, but also lowers the temperature of the skin and mucous membranes, and 'can obtain better results.》 Polymer materials used in polymer membranes, The material which can be formed into a film shape and which can be water-containing is not particularly limited, and may be one or more selected from the group consisting of natural polymers, semi-synthetic polymers, and synthetic polymers. Natural polymers include sol starch, alginic acid, carrageenan, kara gum, xanthan gum, gelatin, gelatin, polydextrose, starch, and Pullulan. One or more of them may be used. Among them, from the sense of use and the affinity to the skin and mucous membranes, it is preferable to use staghorn paste and gelatin. Semi-synthetic polymers include sodium alginate, algae propylene glycol ester, carboxymethyl cellulose, ethyl cellulose, starch-acrylic acid copolymer, propyl hydroxy cellulose, methyl hydroxy cellulose, methyl cellulose, etc. More than one. However, it is preferable to use sodium alginate, seaweed propylene glycol ester or starch-acrylic acid copolymer from the viewpoint of the feeling of use relative to the skin and mucous membrane. Synthetic polymers are: acrylic acid-acrylamide copolymer, isobutylene-anhydrous maleic acid copolymer, sulfonated polystyrene, polyacrylic acid/polysulfonate copolymer, polyvinylpyrrolidone , polyvinyl alcohol, polypropylene decylamine, sodium polyacrylate, isopropyl acrylamide-butyl methacrylate conjugate, polyvinyl methyl ether, polyethylene glycol, etc., one or more of which may be used. Among them, polyethylene & pyrrolidone, polyvinyl alcohol, and polypropylene decylamine are preferred from the viewpoint of the feeling of use and the affinity for the skin film.

1345469 V. INSTRUCTIONS (9) Further, the aqueous scorpion diaphragm may be used in the presence of an aqueous solution or suspension of a tackifier, and may generally contain such materials commonly used for external use, such as: perfumes, pigments, surfactants. , oil, moisturizer, alcohol, preservative, oxidation inhibitor, metal ion blocker, coloring inhibitor, UV absorption/scattering agent, vitamins, amino acids, arbutin, yeast, nutrient, anti-inflammatory Agents, agents, dilators, hormones, absorption agents, antihistamines, bactericides, keratinolytic agents, anti-lipid leakage agents, sebum inhibitors, itch agents, and the like. It is preferable to use the above-mentioned carbon dioxide absorbing auxiliary material, which also contains a tackifier (Patent No. 7 of the patent application). Water, which is a solution for dissolving carbon dioxide, has a relatively high affinity for human tissues and is easy to use, but it is difficult to directly retain it on the skin and mucous membranes, and it is difficult to use carbon dioxide absorption aids. However, the use of a tackifier to impart proper viscosity to water allows it to be applied to the skin and mucous membranes without dripping, and to ensure that the skin and mucous membranes are more absorbing carbon dioxide. The form of the tackifier may be an aqueous solution or a suspension, which may be directly applied to the skin and mucous membrane or may be impregnated on a woven or non-woven fabric or the like as a patch. The thickening agent aqueous solution or suspension can form a thin film on the skin and mucous membrane, which not only can replenish moisture to the stratum corneum, but also has the function of a carbon dioxide gas permeable membrane, thereby compensating for the disadvantage of the original carbon dioxide absorption of the stratum corneum. Further, most of the tackifiers have a moisturizing function such as hyaluronan or alginic acid. When used, they not only continue to moisturize the skin and mucous membranes, but also protect the skin and mucous membranes or moisturize them. The content of the thickener for the carbon dioxide-absorbing auxiliary material varies depending on the type of the tackifier, but it should be

Page 12 1345469 V. INSTRUCTIONS (ίο) The amount of viscosity that does not immediately drip down when applied to the skin patch. The tackifier may be selected from at least one of a group consisting of a natural polymer, a semisynthetic polymer, a synthetic polymer, and an inorganic material (Application No. 9 of the patent application).

The natural polymers used as tackifiers are: gum arabic, antler, vegetable paste, polygalactose, amaranth, royal jelly, guar gum, tragacanth, pectin, polymannose, quinine pectin, beans. Plant-based polymers such as starch, rice starch, wheat starch, maize starch, and horse starch starch; high levels of microorganisms such as cardolan, xanthan gum, amber gluconic acid, polydextrose, hyaluronan, and pulverine Molecules; protein-based polymers such as albumin, casein, gelatin, gelatin, and fibroin, and more than one of these polymers.

Semi-synthetic polymers such as: ethyl cellulose, carboxymethyl cellulose and its salts, carboxymethyl ethyl cellulose and its salts, carboxymethyl starch, croscarmellose cellulose and its salts, Crystalline cellulose, cellulose acetate, cellulose acetate acetate, hydroxy cellulose, propyl hydroxy cellulose, propyl hydroxy phthalyl cellulose, propyl hydroxymethyl cellulose phthalate, powdered cellulose, fluorenyl fiber Fiber-based polymer such as cellulose or methyl propyl hydroxy cellulose; starch-based polymer such as gelatinized starch, partially gelatinized starch, methylol starch, dextrin, and methyl starch; sodium alginate Alginic acid-based polymer such as sodium) or seaweed propylene glycol ester; other polysaccharide-based polymers such as sodium chondroitin sulfate and sodium hyaluronate; and one or more of these polymers may be used in use. The synthetic polymers used as tackifiers are: carboxyvinyl polymer, sodium polyacrylate, polyacetal ethylene diethylaminoacetate, polyvinyl alcohol, polyethylene

Page 13 1345469 V. INSTRUCTIONS (11) Alkene tetrahydron-pyrrolidone, hydrazine, acrylic acid-ethyl acrylate copolymer, methacrylic acid-ethyl acrylate copolymer, ethyl methacrylate - methacrylic acid vaporized trimethylamine ethyl ester copolymer, dimethyl propyl methacrylate - methacrylate methacrylate copolymer, etc., and one or more of them may be used. As the inorganic substance used as a tackifier, it may be selected from, for example, one of aqueous cerium oxide, light anhydrous citric acid, colloidal alumina, bentonite, and Lapon it e. It is better to use a gas-like π~% μ hole film (application No. 9 of the patent garden). Gas-like carbon dioxide refers to a gas in which all of 5% or more of carbon dioxide is used, and such a form is simpler to use and less expensive. The gaseous carbon dioxide can be easily obtained from, for example, a carbon dioxide gas for a large-capacity steel bottle which is generally used, or a carbon dioxide gas for a water-grass rearing or draft beer. Carbon dioxide can also be formed from relatively inexpensive and readily available dry ice or by reacting carbonate with an acid. The gaseous carbon dioxide can be directly sprayed on the skin and mucous membranes, or the I f Ϊ芑 membrane can be covered with a closed container and the carbon dioxide gas can be filled into the interior of the container, or the carbon dioxide gas can be continuously introduced into the skin and mucous membrane by a sealing device. Pass this state of affairs. And: Γ ί 匕: Hey! The dosage is proportional to the concentration or the skin oxidized carbon of the subject, and the time of administration. For example, if the gas is composed of carbon dioxide gas of 850 knives, the investment time can be gb. Let the clock reach 6 hours, preferably 盍 〇 〇 德 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 ϋ 1 4 knives when the best is 1 5 minutes. If the fruit is less than 5 minutes, it is difficult to get very effective. When it becomes 3, it is not necessary to get more progress.

Page 14 1345469

In the case of the ancient gas, the gas is shaped like carbon monoxide, and the temperature is set at the temperature of the low-temperature film (the patent application range ίο). At this time, the temperature of the film at the time of the film is lowered, so that the amount of carbon dioxide absorption can be increased, and therefore, the effect of being ineffective by the second oxygen can be easily obtained. The temperature of the gas-like dioxide is not damaged in the skin and mucous membranes. It is better to be as low as possible. Pile #ft 5: The method of carbon oxide is best to use the method of directly applying to the mucous membrane of the skin with a carbon dioxide-containing external preparation (the scope of application of the patent is the third item: the external preparation for human use, whether it is in the form of bubbles or dissolved in The solvent can be used in the middle of the process, for example, the composition of the bubble-like carbon oxide composition disclosed in Japanese Patent Publication No. 2 00 0 -3^918^^, the composition of the rolled carbon external composition, or For example, the carbon dioxide of dry ice is dissolved in water and turned into a misty 纟', which is available. Among them, the external composition of carbon dioxide can maintain a large amount of carbon dioxide, and has a small amount and effective continuous supply of carbon dioxide, and is also convenient to carry. Advantages: The dosage of the composition containing carbon dioxide for external use varies depending on the concentration of carbon dioxide or the skin condition of the subject, and is generally proportional to the administration time. The administration time can be from 5 minutes to 6 hours. It is preferably from 丨〇 minutes to 4 hours 'preferably from 15 minutes to 3 hours." When the administration time is less than 5 minutes, it is difficult to obtain a very effective effect, but if it is more than 6 hours, it is not necessarily Further, it is wasteful to obtain further effects. Further, after applying the carbon dioxide-containing external composition and then attaching a gas-impermeable film such as a resin film thereon, carbon dioxide can be prevented from being emitted from the composition to the atmosphere. And can enhance the effect. Again, use dry

Page 15 1345469

The whiteness of the ice is the same as the expected temperature of the skin and the dioxic percutaneous solution. The temperature of the external use group will increase. The amount of temperature in the external use group may be increased, and the effect of the smoke may be the effect of mucosal absorption of the above-mentioned film. When the gas film is used, it can be reduced, and the amount of carbon added should be used as much as possible. It is also enhanced when the body is cooled down, so that it is strong &low; and the composition is used at low temperatures. :::: Effective beauty and other effects. For external use, 佶 (the scope of patent application is set, and the temperature set below the film will decrease). At this time, the T is lowered, and the carbon dioxide is enhanced by a simple carbon dioxide. The carbonized external preparation is coated with a resin film coated with a cooling agent or the like to reduce the skin and mucous membrane effect. In detail, if it will contain carbon dioxide

The skin mucous membrane at the site where the composition is applied. The transdermal mucosal absorption of the diterpene carbon at this position is obtained. The cosmetic equivalent of the external composition after the second oxidation has a desired effect in a short period of time. Further, the temperature "the method for use in the beauty of the present invention which does not damage the skin and mucous membranes" is to achieve the desired cosmetic effect by performing the above-described carbon dioxide transmucosal absorption method (Shenjing Patent Area No. 13). That is, 'the method of administering carbon dioxide to the skin drill film and absorbing it through the mucous membrane to promote the cosmetic effect' is characterized in that the treatment of the percutaneous transmucosal absorption of carbon dioxide is performed before or during administration of the above carbon dioxide. . According to the above method, since the percutaneous transmucosal absorption of carbon dioxide can be increased by administering the dioxide to the skin, or when it is administered, it is compared with the case where the carbonated or carbonic acid-containing external preparation is administered alone. The cosmetic effect of carbon dioxide absorbed through the transmucosal transmucosa is more visible.

Page 16 1345469

In the above-mentioned cosmetic method, the pretreatment of 昜虹匕^ is the same as the above-mentioned = 对 对 至少 至少 至少 至少 至少 至少 至少 至少 至少 至少 至少 至少 至少 至少 至少 至少 至少 至少 至少 至少 至少 至少 至少 至少 至少 至少 至少 至少 至少 至少 至少 至少 至少 至少 至少 至少 至少The treatment of moisturizing the skin and mucous membrane with the liquid for dissolving carbon dioxide is further preferable. The above treatment is more preferably a treatment for lowering the temperature of the skin and mucous membrane. As the carbon dioxide absorbing auxiliary material, a liquid carbon dioxide absorption auxiliary liquid containing the above-described carbon dioxide dissolving liquid is preferably used. It is more preferable that the above-mentioned hardened red absorbing auxiliary material is used as a thickener. The tackifier is preferably at least one selected from the group consisting of a natural polymer, a semisynthetic polymer, a synthetic polymer, and an inorganic material. Further, the administration of the above carbon dioxide is preferably carried out by administering carbon dioxide to the skin and mucous membranes. The administration of carbon dioxide is preferably carried out by applying a carbon dioxide-containing external preparation to the skin and mucous membranes. It is preferable that the carbon dioxide is set at a temperature lower than the temperature of the skin and mucous membrane at the use temperature. The above-mentioned carbon monoxide-containing external preparation is also preferably used at a temperature lower than the temperature of the skin mucosa. 4. Embodiments Hereinafter, the present invention will be more specifically described by way of examples, but it is to be understood that the present invention is not limited to the embodiments, and in the following embodiments, the carbon dioxide absorption auxiliary liquid absorbs the auxiliary liquid. The carbon dioxide absorption subsidy is referred to as the absorption subsidy. [Example 1] The whitening test by gas-like carbon dioxide was carried out on the back using an absorption subsidy solution:

1345469 V. Description of invention (15). Use water as the absorption subsidy solution, so that the right hand of a 22-year-old woman is soaked in the 3 6 C Wenyong _ for 5 minutes, Jian Gufeng, a, shirt, 3 knives, then the right hand is moistened, but the left hand is not Soak the water, keep it as it is, then put the hands in a 25cm long, inch pvc plastic bag, and use the rubber band to tighten the wrist to make the width transparent, then remove the air in the bag, then pvc plastic tube In the sealed state, the tightening portion is inserted into the bag, and the rubber band from the carbon dioxide cylinder rubber bag is blown into the bag, so that the plastic bag is expanded as much as possible, and the right two-body carbon dioxide is observed to obtain the blood promoting effect, but the left hand back The teeth immediately reddened. After 20 minutes, after removing the plastic bag, right, see the slight red color subsided, compared with the left hand back, it is obvious that the skin f is about 2 minutes later, the blood vessels appear slightly, but the left hand back and the white is accepted. There is any change in light. Comparison of the comparison, there is no [Example 2] Using the absorption subsidy solution for the arm by & whitening test: 1. Emulsified carbon external preparation 1. Preparation of carbon dioxide-containing external composition A: According to Japanese special 20 〇〇 - 3 1 9 1 8 7 sinus using sodium bicarbonate 2. 4 parts by weight, sodium alginate ^ Example 1 8 content, sodium starch 2. 〇 weight parts, sodium carboxymethyl cellulose 2, 〇 份Carboxymethyl group 9 1. 6 parts by weight, citric acid 2. 〇 parts by weight, part by weight, purified water composition A. 3 Carbon dioxide for external use 2. Whitening test on the back of the hand: Use water as the absorption subsidy solution, make the 22-year-old warm water at 36 °C for 5 minutes, so that the right hand is wet. The right hand is soaked in the left hand without water.

1345469 V. Description of invention (16) In its original form, then, the composition for carbonaceous external use A is applied to the left and right hands of each hand to apply 1 5 grams, and is allowed to stand for 15 minutes. After 15 minutes, the hands are After the composition was removed, it can be seen that both hands are reddish, showing the effect of promoting blood circulation. After about 2 minutes, the redness completely subsided. After the redness completely subsided, it can be seen that the skin of the right hand back is whiter and shiny than the muscle of the left hand, and the blood vessels appear slightly, but there is no phenomenon of blood vessels appearing on the left hand back. [Example 3] After the skin temperature is lowered Whitening test by gas-like carbon dioxide on the back of the hand: The frozen cold-preserving agent is covered with a towel and placed on the back of the right hand of a 22-year-old woman to be cooled until the skin temperature drops to 20 ° C below the body temperature, left hand Then, it was not cooled and cooled. After the lack of it, put both hands into a transparent plastic bag with a length of 2 5 cm and a width of 20 cm. After tightening the wrist parts of each plastic bag with a rubber band, the bag was removed. In the air. Then, the plastic tube is inserted into the bag from the rubber band bundle portion of each plastic bag, and the carbon dioxide gas from the carbon dioxide gas cylinder is blown into the bag from the plastic tube, so that the plastic bag is expanded as much as possible, and then the right hand back is observed. Red, showing the effect of promoting blood, but no change in the left hand back. After 20 minutes, after removing the plastic bag, the red color subsided after about 2 minutes on the back of the right hand. Compared with the left arm, the skin muscle became whiter and shiny, and the blood vessels appeared slightly, but the left arm was compared with before the test. Almost no change has been seen. [Example 4] A whitening test by a carbon dioxide-containing external preparation was carried out on the back of the hand after the skin temperature was lowered:

Page 19 1345469 V. INSTRUCTIONS (17) The frozen cold-preserving agent is covered with a towel and applied to the back of the right hand of a 22-year-old woman for cooling until the skin temperature drops to 2 (TC, left hand is not After cooling and cooling, the carbon dioxide-containing composition A was applied to each of the left and right hands, and 15 g was applied, and allowed to stand for 15 minutes. After 15 minutes, the carbon dioxide-containing external composition on the hands was removed, and it was observed. Both hands are reddish, and there is a blood-promoting effect. After about 2 minutes, the red color completely subsides. After the red color completely subsides, the right hand back and the left hand back show that the skin muscles are whiter and shiny, and the blood vessels appear slightly, but the left hand back is No phenomenon of blood vessels appearing. [Example 5]

An improvement test for the partial filling of the upper arm by cooling the carbon dioxide-containing external preparation:

The carbon dioxide-containing external composition A 1 0 0 g cooled to 4 ° C was applied to the upper right arm of the 21-year-old female whose conscious upper arm was too thick, and the carbon dioxide-containing external composition A was raised to a temperature of 36 ° C. After applying 100 grams to the left upper arm, each arm was wrapped in a plastic wrap for food for 30 minutes. After the envelope and the composition were removed from the two arms, the circumference around the center of the right upper arm was reduced from 28.5 cm to 27.0 cm, but the left upper arm was compared with that before the application of the carbonaceous external composition A. There is no change in the circumference. In addition, the skin of the right upper arm is whiter and more lustrous than the unapplied part and the upper left arm. [Embodiment 6] Whitening test of the arm by gaseous CO2 using a cold absorption subsidy solution. Using water as an absorption aid, first soak the right hand of a 22-year-old woman

Page 20 1345469 V. Description of the invention (18) In the cold water at 4 ° C for 3 minutes, the right hand is wetted while cooling, until the temperature of the right hand skin drops to 20 ° C, the left hand remains the same, no water and no cooling Then, put the left and right hands into a transparent PVC plastic bag with a length of 25 cm and a width of 20 cm. After tightening the wrist with the rubber band to make the bag sealed, the air in the bag is removed, and then the plastic tube is self-contained. The rubber band bundle part of each plastic bag is inserted into the bag, and the carbon dioxide gas from the carbon dioxide gas cylinder is introduced into the bag to make the bag expand as much as possible, and the right hand back can be observed to be reddish immediately, showing the effect of promoting blood flow, but the left hand back There is no change. After 20 minutes of 'unloading the plastic bag, the right hand backed out after about 2 minutes, and the red color subsided. Compared with the left arm, it can be seen that the skin muscles are whiter and shiny, and the blood vessels are slightly emerging' but the left arm is compared with before the test. There is almost no change. [Example 7] A face-lifting test using a cold-absorbing auxiliary body to carry out a carbon dioxide-containing external preparation on the face: 1. Preparation of a composition C containing a carbon dioxide external composition: According to Japanese Patent Laid-Open No. 2000-301 Example 3 The contents of 0 9 'Use water 20 ml, sodium bicarbonate 2 g, sodium alginate 6 g, sodium carboxymethyl cellulose 8 g, 1,3-butanediol 2 g, water-soluble leaf gas Sodium citrate was finely prepared into a basic composition of 21 8 g. Further, according to the contents of Example 3 0 9 of the same publication, lactic acid 13.5 kg, 7% HPC-L ethanol solution 5,4 kg, and refined white sugar particles 67 kg were used to prepare granules of 80 kg. Subsequently, the obtained basic composition of 25 g and the granules of 1.2 g were mixed and stirred until the granules were completely dissolved to obtain a carbon dioxide-containing external composition.

Page 21 1345469 V. Inventions (19). Face test on the face: It will be cooled in the refrigerator to the cold towel of Gu Hxiong, King 4C (already impregnated with water), that is, it is especially full. The right cheek of a 30-year-old woman's skin was moistened and reduced to 2 经 after 3 minutes, and the composition containing carbon dioxide was applied to the face. After 4 minutes of application, the right side of the mouth was slightly pulled up. The right cheek appears to be smaller than the left cheek. After 20 minutes, remove it.

After the composition containing carbon dioxide, the right side of the mouth is obviously pulled up, and the right cheek is slightly smaller than the left cheek. The women who underwent the test themselves also felt that the right cheek was more taut than the original, and the localized skinny and the facial muscles were tighter. Also, the right cheek becomes whiter and more lustrous than the rest of the face. Comparing the results of a 50-fold enlargement photograph of the skin layer of the cheeks applied before and after the application of the composition containing carbon dioxide, the skin of the right cheek is compared with that before application, which clearly shows that the skin groove and ridge of the skin after application are very obvious. It looks like a young line. As for the skin of the left cheek, although the skin groove and the ridge are apparent before and after application of the external preparation, the degree is slightly inferior to the right cheek according to the photograph. [Embodiment 8]

The face is coated with a carbon dioxide-containing external preparation using a cold-absorbing aid and the skin temperature of the face is lowered for a cosmetic test: it is first cooled to 4 in the refrigerator. (: The cold towel (which has been impregnated with water) is covered in the right cheek of a 42-year-old woman with a full cheek. After 3 minutes, the skin is moistened and lowered to 2 (after TC, the composition containing carbon dioxide is used Α 30 grams applied to the face of the face, and covered with plastic wrap on the food packaging, and then the towel cooled to 4 ° C is attached to the plastic wrap on the right half of the face]

Page 22 1345469 V. Description of Invention (20) After the face is recooled for 15 minutes, the diaphragm and composition A are removed, and it is obvious that the right cheek is slightly smaller than the left face frequency, and the right eye is positioned closer to the left eye. The position is about 5 mm (mm) higher than the 'small face (skinny face) effect and the face pull effect. Also, the right cheek is whiter than the left cheek and the texture becomes fine. [Example 9] A treatment test for a wound by a cold-containing carbon dioxide external preparation: a wound of 1 cm long for a left-legged male in a 47-year-old male 'directly coated with a cooling to 4 ° C The carbon dioxide external composition a 2 g, wait for 15 minutes, the wound is completely joined with β. In addition, the same male's left heel is also wounded by 5 mm long and coated with 36. (: 1 g of the carbon dioxide-containing external composition A, after 15 minutes, the wound is not completely joined. [Example 10] The face-lifting test using a cold-absorbing auxiliary body by cold-containing carbon dioxide external preparation: cooling will be performed Towels up to 4 ° C (already impregnated with water, absorbed by the body) are applied to the face of a 43-year-old woman. After 3 minutes of moisturizing and cooling the skin to 2 It, it will be cooled to 4. (: The carbon dioxide external composition A 1 5 g was applied to the right half face, and heated to 36. (: The carbon dioxide-containing external composition A 15 g was applied to the left half of the face, and after being left for 1 minute, the composition was completely removed. A, as a result, it is obvious that the right side of the woman is slightly raised, the right cheek is slightly smaller than the left cheek, and the position of the right eye is about 4 mm higher than the position of the left eye. The woman herself also feels that the cheeks have a feeling of stretching. The tightening effect of the skin and muscles, especially the right frequency is more tight than the left cheek, and at the same time, the face becomes whiter and lighter.

Page 23 1345469 V. Description of invention (21) Ze, while the right cheek is more white and shiny than the left. [Example Η--] Using the absorption aid liquid to perform the local filling improvement test of the gaseous carbon dioxide on the upper arm: 1. Preparation of the absorption aid liquid: 1 part by weight of sodium alginate was added to 98 parts by weight of the purification, After the carboxyindole sodium was dissolved in an amount of 1 part by weight, a semi-synthetic polymer-containing absorption auxiliary liquid A having a pH of 7.3 was obtained. 2. Test for partial plump improvement of the upper arm:

The upper left arm of the 40-year-old woman who is more fat and troubled with the upper arm is coated with 0.5 gram of the absorption aid A, which is left to be wetted for 10 minutes, and the right upper arm is not coated with any supplement A. Then, a tubular PVC plastic film with a length of 38 cm and a length of 15 cm is placed in the left and right upper arms to completely cover the two arms, and the ends of the tube are tightened with a rubber band to make the inside sealed. Draw off the air inside. Subsequently, the plastic tube (sipper) is inserted into the inner portion of the rubber band of the PVC film, and the gaseous carbon dioxide from the carbon dioxide cylinder is introduced into the tube, so that the skin of the left upper arm becomes red immediately after the PVC tube is expanded by the carbon dioxide gas. It is obvious that the blood flow is increased, but there is no such change in the right upper arm. After 30 minutes, the PVC pipe was removed, and the circumference of the center of each upper arm was measured. It was found that the left upper arm was reduced from 3 3 cm to 32 cm before the gas-like carbon dioxide was injected, but the circumference of the right upper arm was not seen. Change. Further, the redness of the skin of the right upper arm subsided after about 2 minutes after the removal of the PVC tube, and no side effects were observed, and the skin layer became whiter and more lustrous than the surrounding and upper right arms.

Page 24 1345469 V. INSTRUCTIONS (22) [Example 12] The use of an absorption aid to partially improve the abdomen by a carbon dioxide-containing external preparation: 1. Preparation of a water-containing polymer membrane A: The cellulose film of 20 cm x 40 cm was sufficiently immersed in distilled water as an absorption aid to prepare a water-containing polymer film A. 2. Modulation of flue gas from dry ice:

Place 200 gram of dry ice in a closed container with a PVC plastic tube with an inner diameter of 1 cm, and sprinkle water in a timely manner to cause dry ice fumes (ie, a cold containing oxidizing disc external preparation). 3. Local plump improvement test for the abdomen (weight loss test):

The abdomen of the 37-year-old male who was troubled by the abdomen was overlaid with the aqueous polymer film A, and then the dry ice was continuously sprayed on the aqueous polymer film A through the plastic tube for 20 minutes. As a result, the waist circumference was The original 92 centimeters was reduced to 91 centimeters. Further, the skin of the site where the aqueous polymer film A is applied is whiter and more lustrous than the skin of the abdomen of other parts. For the 34-year-old male who is also full of abdominal fat, the smoke of the dry ice is directly sprayed on the abdomen for 40 minutes through the plastic tube. As a result, there is no effect of reducing the waist circumference and whitening the skin. [Embodiment 13] An age spot improvement test by gaseous carbon dioxide was carried out using an absorption aid on the back of the hand: 1. Preparation of a water-containing polymer film B: Fully soaked in a cellulose film of 10 cm X 2 0 cm With distilled water

Page 25 1345469 V. Description of invention (23) As an absorption aid, it is prepared into a water-containing polymer film B. 2. Improvement test for age spots: The right arm of a 69-year-old woman with significant age spots on both hands is covered with an aqueous polymer film B cooled to 4 ° C, and the left arm is not attached with an aqueous polymer film B, and Insert the hands into two transparent PVC plastic bags with a length of 25 cm and a width of 20 cm. Use a rubber band to tighten the wrist to seal the bag. Remove the air from the bag. Then, a plastic tube is inserted from the tightening portion of the rubber band of each bag, and gaseous carbon dioxide from the carbon dioxide gas cylinder is blown into the bag through the plastic tube, so that the bag is filled with gaseous carbon dioxide and expanded, and then left to stand 1 5 minutes. Thus, once a day, after a week, the back of the right hand became whiter than the back of the left hand, and the age spots disappeared into inconspicuous eyes, and the blood vessels of the right hand back slightly appeared, but the left hand back was almost unchanged from before the test. [Example 14] A test for the local plump improvement of the thigh by gaseous absorption of carbon dioxide using a cold absorption subsidy solution: 1. Preparation of absorption subsidy B: 1 part by weight of carrageenan was added to 99 parts by weight of purified water After it was dissolved uniformly, the absorption replenishment B containing the natural polymer was adjusted to pH 7.2. 2. Partial plump improvement test for thighs: Apply 3 gram of absorption aid B to 4°C to the right thigh of a 40-year-old woman who is troubled by thick thighs. Leave it for 3 minutes to moisturize the skin. And the skin temperature drops to 2 1. 5 ° C, the left thigh is not painted - any supplement B. Then, use a tubular PVC plastic film with a length of 45 cm and a length of 20 cm.

Page 26 1345469 V. INSTRUCTIONS (24) On the left and right thighs, the ends are sealed with rubber bands to seal the tube and the internal air is removed. Then, the plastic straw is inserted from the tight end of the plastic film tube, and the gaseous carbon dioxide from the carbon dioxide gas cylinder is introduced into the tube, and the inside is filled with carbon dioxide and expanded, and the skin of the right thigh immediately appears red, confirming the increase of blood flow. However, this change has not been seen in the left thigh. After 20 minutes, the plastic film covering the two thighs was removed, and the central part of the two thighs was measured. The right thigh was reduced from 41 cm to 40 cm of gaseous carbon dioxide, but the circumference of the left thigh did not change. Moreover, the redness of the skin of the right thigh disappeared after removing the plastic film for about 2 minutes, and no side effects were observed. At the same time, the skin appeared whiter and shiny than the surrounding skin or left thigh. [Embodiment 15] A black spot and freckle improvement test using a composition containing a dioxane carbon dioxide on a face using a cold absorption aid: a right half face of a 41-year-old woman having a significant black spot and freckles on the face Applying a cotton pad impregnated with the absorption aid A at a temperature of 4 ° C, and a cotton piece (absorbent body) containing only the impregnated purified water cooled to 4 ° C on the left half of the face, after 5 minutes After the skin of the face is wet and the skin temperature is lowered to 21 ° C, the cotton sheet is removed, and then 30 cm of the carbon dioxide-containing external composition A is applied to the face, and the surface is removed for 10 minutes. Cotton film, so, once a day, after 12 consecutive days, the skin color of the right half of the face becomes whiter than the left half of the face, and the dark spots and freckles are almost inconspicuous. Although the left half of the face became whiter than before the test, the dark spots and freckles did not improve, but the skin became whiter and became more conspicuous.

Page 27 1345469 V. INSTRUCTIONS (25) [EXAMPLE 16] Whitening test of gaseous carbon dioxide using the absorption aid liquid on the back of the opponent:

Apply the right hand back of a 27-year-old woman as a 7-times linseed oleic acid (ie T-colanic acid) (lipid) 〇. 5 grams, do not apply any supplement to the left hand, then, Put the left and right hands into a transparent PVC plastic bag with a length of 25 cm and a width of 20 cm. Use a rubber band to tighten the wrist to seal the bag and then remove the air from the bag. Next, insert a plastic tube from the tightening portion of the rubber band of each bag, and introduce the gaseous carbon dioxide from the carbon dioxide gas cylinder into the bag, so that the plastic bag is filled with carbon dioxide gas and swelled, and the right hand back is immediately reddish, and there is a blood line. Promote the effect, but this change has not been seen on the back of the left hand. After 20 minutes, the plastic bags were removed, and the back of the right hand disappeared after about 2 minutes. Compared with the back of the left hand, the skin muscles were whiter and brighter, but the back of the left hand did not change much before the test. [Embodiment 17] Whitening test using gaseous absorption carbon dioxide on the back of the opponent using an absorption subsidy solution:

Apply the right hand back of the 27-year-old woman as η-butanol (organic solvent) 0.5 gram, and do not smear the left hand. Then, put the left and right hands into a length of 2 5 cm and a width of 20 cm. In the transparent plastic bag, tighten the wrist with a rubber band to seal the bag and then remove the air from the bag. Then, a plastic tube is inserted from the tightening portion of the rubber band of each bag, and carbon dioxide gas is introduced into the bag from the carbon dioxide gas cylinder, so that the plastic bag is filled with carbon dioxide gas and expanded, and the right hand is immediately reddish, showing a blood promoting effect, but

Page 28 1345469 V. Description of invention (26) There is no such change or change in the left hand. After 10 minutes, the plastic bags were removed, and the red color subsided after about 2 minutes on the back of the right hand. The skin muscle became whiter and shinyer than the back of the left hand, but the left hand back did not change much before the test. [Embodiment 18] The use of an absorption aid for the specific dermatitis of the arm by an improvement test of gaseous carbon dioxide:

For the 9-year-old girl with specific dermatitis, the right arm site with specific dermatitis is coated with the absorption aid A 1 g, the left arm also has the specific dermatitis site uncoated, and then the tubular PVC plastic After the film is covered with the specific dermatitis site of both hands, the rubber tube is used to tighten the two ends of the plastic tube, and then the internal air is removed. Then, the plastic straw is inserted into each plastic tube, and 100% of the carbon dioxide gas is introduced into the tube from the carbon dioxide gas cylinder to expand it. As a result, the right hand skin coated with the absorption aid A immediately turns red and has vasodilation. The phenomenon, but the skin of the left hand did not see this phenomenon. After 10 minutes, after removing the plastic film, the affected area of the right arm was no longer itchy and became smooth, but the affected area of the left arm was not changed particularly before the test, and the itching was slightly enhanced.

According to the percutaneous transmucosal absorption method of carbon dioxide of the present invention, the cosmetic and skin-improving effects by percutaneous transmucosal absorption of carbon dioxide can be easily and efficiently obtained by increasing the absorption amount of carbon dioxide. In more detail, it is easier and more effective to obtain the effects of beauty and bodyiness than the conventional carbonated spring method, and it is better than the application of only the composition containing carbon dioxide for beauty and slimming, and can be used in a short period of time. Achieve the desired effect. Therefore, the percutaneous transmucosal absorption method of carbon dioxide of the present invention can be effectively applied to beauty,

Page 29 1345469 V. Description of invention (27) Good results such as slimming. \

Page 30 1345469 Round simple description

Page 31

Claims (1)

-4 1JFF3FHJ^ n 7 At Patent Application _ 1. A method for percutaneous transmucosal absorption of carbon dioxide, which is a method for percutaneous transmucosal absorption of carbon dioxide by applying carbon dioxide to the skin and mucous membranes; Dissolving carbon dioxide in a solution selected from the group consisting of water, 7-times linoleic acid, and η-butanol, and dissolving the carbon dioxide on the skin mucosa Or, when it is administered, a carbon dioxide absorbing auxiliary material comprising a carbon dioxide absorbing auxiliary liquid containing the carbon dioxide-dissolving liquid as an essential component, and moisturizing the skin and mucous membrane by the carbon dioxide absorbing and dissolving liquid contained in the auxiliary material Treatment and / or treatment of the temperature of the skin and mucous membranes to reduce the percutaneous transmucosal absorption of carbon dioxide. 2. A percutaneous transmucosal absorption method for carbon dioxide, which is a method for percutaneous transmucosal absorption of carbon dioxide by a skin mucosa; characterized in that the carbon dioxide is gaseous or dissolved in water selected from water, 7"- Carbon dioxide in one or more of the group consisting of linoleic acid, ethanol and η-butanol, and the carbon dioxide is used in the skin mucosa before or during administration. The carbon dioxide absorption auxiliary liquid which is an essential component of the dissolved liquid, and which is formed by the carbon dioxide absorption auxiliary body having a predetermined shape, is applied to the skin and mucous membrane by the carbon dioxide absorption and dissolution liquid contained in the auxiliary material. The treatment of wetness and/or the temperature of the skin and mucous membranes is cooled, and the percutaneous transmucosal absorption of carbon dioxide is enhanced. 3. The percutaneous transmucosal absorption method of carbon dioxide according to claim 1 or 2, wherein Page 32 1345469 6. Carbon dioxide absorption of the carbon dioxide absorbing membrane in the scope of application of the patent 4. The carbon dioxide absorption supplemented aqueous polymer membrane as described in claim 2 5. The carbon dioxide as described in claim 1 or 2 Absorbing a vegetable or a carrageenan fiber as a tackifier. 6. If the method of claim 1 or 2 is received, the method is 7. If the method of claim 1 or 2 is received, the method is 8. In the case of claim 7, the improved use of the skin and/or the improvement of freckles The use of the auxiliary material is set at a temperature lower than that of the skin. A percutaneous transmucosal absorption method of carbon oxide, wherein the auxiliary material is a carbon dioxide absorption auxiliary composed of a liquid containing carbon dioxide dissolved. The carbon dioxide percutaneous transmucosal absorption method is further characterized in that the auxiliary material further contains at least an oxidized carbon absorption auxiliary liquid selected from the group consisting of: cerulena and sodium alginate. Any one of the carbon dioxides described above is percutaneously administered to a cosmetic application. Any of the carbon dioxide percutaneous transmucosal absorption of the skin for use in improving the use of the skin. Percutaneous transmucosal absorption of carbon dioxide, which refers to skin whitening, local plumpness, age spots Page 33