TWI337869B - Pharmaceutical composition and cleansing reagent comprising dendritic cell-specific icam-3 grabbing nonintegrin (dc-sign) and use thereof - Google Patents

Pharmaceutical composition and cleansing reagent comprising dendritic cell-specific icam-3 grabbing nonintegrin (dc-sign) and use thereof Download PDF

Info

Publication number
TWI337869B
TWI337869B TW93105277A TW93105277A TWI337869B TW I337869 B TWI337869 B TW I337869B TW 93105277 A TW93105277 A TW 93105277A TW 93105277 A TW93105277 A TW 93105277A TW I337869 B TWI337869 B TW I337869B
Authority
TW
Taiwan
Prior art keywords
sign
functional equivalent
leu
glu
gin
Prior art date
Application number
TW93105277A
Other languages
Chinese (zh)
Other versions
TW200529867A (en
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to TW93105277A priority Critical patent/TWI337869B/en
Publication of TW200529867A publication Critical patent/TW200529867A/en
Application granted granted Critical
Publication of TWI337869B publication Critical patent/TWI337869B/en

Links

Landscapes

  • Peptides Or Proteins (AREA)

Description

1337869 71464-l.ST25.txt 序列表 <110>台灣葛迪夫生物科技股份有p公司 <120>包含樹突細胞•特異性細胞間黏附因子-3攫取非整合素(DC-SIGN)之醫藥組成物和 淸潔用品及其之使用 <160> 6 <170> Patentln version 3.1 <210> 1 <211〉 404 <212> PRT <213>人類1337869 71464-l.ST25.txt Sequence Listing <110>Traditional Technology of Taiwan Gedifu Biotech Co., Ltd. <120> Contains Dendritic Cells • Specific Intercellular Adhesion Factor-3 Extracted Non-Integrase (DC-SIGN) Medicinal composition and cleaning article and use thereof <160> 6 <170> Patentln version 3.1 <210> 1 <211> 404 <212> PRT <213>

<400〉 1<400〉 1

Met Ser Asp Ser Lys Glu Pro Arg Leu Gin Gin Leu Gly Leu Leu Glu 15 10 15Met Ser Asp Ser Lys Glu Pro Arg Leu Gin Gin Leu Gly Leu Leu Glu 15 10 15

Glu Glu Gin Leu Arg Gly Leu Gly Phe Arg Gin Thr Arg Gly Tyr Lys 20 25 30Glu Glu Gin Leu Arg Gly Leu Gly Phe Arg Gin Thr Arg Gly Tyr Lys 20 25 30

Ser Leu Ala Gly Cys Leu Gly His Gly Pro Leu Val Leu Gin Leu Leu 35 40 45Ser Leu Ala Gly Cys Leu Gly His Gly Pro Leu Val Leu Gin Leu Leu 35 40 45

Ser Phe Thr Leu Leu Ala Gly Leu Leu Val Gin Val Ser Lys Val Pro 50 55 60Ser Phe Thr Leu Leu Ala Gly Leu Leu Val Gin Val Ser Lys Val Pro 50 55 60

Ser Ser lie Ser Gin Glu Gin Ser Arg Gin Asp Ala lie Tyr Gin Asn 65 70 75 80Ser Ser lie Ser Gin Glu Gin Ser Arg Gin Asp Ala lie Tyr Gin Asn 65 70 75 80

Leu Thr Gin Leu Lys Ala Ala Val Gly Glu Leu Ser Glu Lys Ser Lys 85 90 95Leu Thr Gin Leu Lys Ala Ala Val Gly Glu Leu Ser Glu Lys Ser Lys 85 90 95

Leu Gin Glu lie Tyr Gin Glu Leu Thr Gin Leu Lys Ala Ala Val Gly 100 105 110Leu Gin Glu lie Tyr Gin Glu Leu Thr Gin Leu Lys Ala Ala Val Gly 100 105 110

Glu Leu Pro Glu Lys Ser Lys Leu Gin Glu lie Tyr Gin Glu Leu Thr 第1頁 1337869 71464-l.ST25.txt 115 120 ' 125Glu Leu Pro Glu Lys Ser Lys Leu Gin Glu lie Tyr Gin Glu Leu Thr Page 1 1337869 71464-l.ST25.txt 115 120 ' 125

Arg Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gin 130 135 140Arg Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gin 130 135 140

Glu lie Tyr Gin Glu Leu Thr Trp Leu Lys Ala Ala Val Gly Glu Leu 145 150 155 160Glu lie Tyr Gin Glu Leu Thr Trp Leu Lys Ala Ala Val Gly Glu Leu 145 150 155 160

Pro Glu Lys Ser Lys Met Gin Glu lie Tyr Gin Glu Leu Thr Arg Leu 165 170 175Pro Glu Lys Ser Lys Met Gin Glu lie Tyr Gin Glu Leu Thr Arg Leu 165 170 175

Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Gin Gin Glu lie 180 185 190Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Gin Gin Glu lie 180 185 190

Tyr Gin Glu Leu Thr Arg Leu Lys Ala Ala Val Gly Glu Leu Pro Glu 195 200 205Tyr Gin Glu Leu Thr Arg Leu Lys Ala Ala Val Gly Glu Leu Pro Glu 195 200 205

Lys Ser Lys Gin Gin Glu lie Tyr Gin Glu Leu Thr Arg Leu Lys Ala 210 215 220Lys Ser Lys Gin Gin Glu lie Tyr Gin Glu Leu Thr Arg Leu Lys Ala 210 215 220

Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Gin Gin Glu lie Tyr Gin 225 230 235 240Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Gin Gin Glu lie Tyr Gin 225 230 235 240

Glu Leu Thr Gin Leu Lys Ala Ala Val Glu Arg Leu Cys His Pro Cys 245 250 255Glu Leu Thr Gin Leu Lys Ala Ala Val Glu Arg Leu Cys His Pro Cys 245 250 255

Pro Trp Glu Trp Thr Phe Phe Gin Gly Asn Cys Tyr Phe Met Ser Asn 260 265 270Pro Trp Glu Trp Thr Phe Phe Gin Gly Asn Cys Tyr Phe Met Ser Asn 260 265 270

Ser Gin Arg Asn Trp His Asp Ser lie Thr Ala Cys Lys Glu Val Gly 275 280 285Ser Gin Arg Asn Trp His Asp Ser lie Thr Ala Cys Lys Glu Val Gly 275 280 285

Ala Gin Leu Val Val lie Lys Ser Ala Glu Glu Gin Asn Phe Leu Gin 290 295 300 第2頁 1337869 71464-l.ST25.txtAla Gin Leu Val Val lie Lys Ser Ala Glu Glu Gin Asn Phe Leu Gin 290 295 300 Page 2 1337869 71464-l.ST25.txt

Leu Gin Ser Ser Arg Ser Asn Arg Phe Thr Trp Met Gly Leu Ser Asp 305 310 ' 315 320Leu Gin Ser Ser Arg Ser Asn Arg Phe Thr Trp Met Gly Leu Ser Asp 305 310 ' 315 320

Leu Asn Gin Glu Gly Thr Trp Gin Trp Val Asp Gly Ser Pro Leu Leu 325 330 335Leu Asn Gin Glu Gly Thr Trp Gin Trp Val Asp Gly Ser Pro Leu Leu 325 330 335

Pro Ser Phe Lys Gin Tyr Trp Asn Arg Gly Glu Pro Asn Asn Val Gly 340 345 350Pro Ser Phe Lys Gin Tyr Trp Asn Arg Gly Glu Pro Asn Asn Val Gly 340 345 350

Glu Glu Asp Cys Ala Glu Phe Ser Gly Asn Gly Trp Asn Asp Asp Lys 355 360 365Glu Glu Asp Cys Ala Glu Phe Ser Gly Asn Gly Trp Asn Asp Asp Lys 355 360 365

Cys Asn Leu Ala Lys Phe Trp lie Cys Lys Lys Ser Ala Ala Ser Cys 370 375 380Cys Asn Leu Ala Lys Phe Trp lie Cys Lys Lys Ser Ala Ala Ser Cys 370 375 380

Ser Arg Asp Glu Glu Gin Phe Leu Ser Pro Ala Pro Ala Thr Pro Asn 385 390 395 400Ser Arg Asp Glu Glu Gin Phe Leu Ser Pro Ala Pro Ala Thr Pro Asn 385 390 395 400

Pro Pro Pro Ala <210> 2 <211> 1215 <212〉 DNA <213>人工序列 <220> <223〉可溶性 DC-SIGN-1 <400> 2 60 120 180 atgagtgact ccaaggaacc aagactgcag cagctgggcc tcctggagga ggaacagctg agaggccttg gattccgaca gactcgagga tacaagagct tagcagggtg tcttggccat ggtcccctgg tgctgcaact cctctccttc acgctcttgg ctgggctcct tgtccaagtg tccaaggtcc ccagctccat aagtcaggaa caatccaggc aagacgcgat ctaccagaac 第3頁 240 1337869 71464-l.ST25.txtPro Pro Pro Ala <210> 2 <211> 1215 <212> DNA <213>Artificial Sequence<220><223>Soluble DC-SIGN-1 <400> 2 60 120 180 atgagtgact ccaaggaacc aagactgcag Cagctgggcc tcctggagga ggaacagctg agaggccttg gattccgaca gactcgagga tacaagagct tagcagggtg tcttggccat ggtcccctgg tgctgcaact cctctccttc acgctcttgg ctgggctcct tgtccaagtg tccaaggtcc ccagctccat aagtcaggaa caatccaggc aagacgcgat ctaccagaac Page 3 240 1337869 71464-l.ST25.txt

ctgacccagc ttaaagctgc agtgggtgag ctctcagaga aatccaagct gcaggagatc 300 taccaggagc tgacccagct gaaggctgca gtgggtgagc ttccagagaa atctaagctg 360 caggagatct accaggagct gacccggctg aaggctgcag tgggtgagct tccagagaaa 420 tctaagctgc aggagatcta ccaggagctg acctggctga aggctgcagt gggtgagctt 480 ccagagaaat ctaagatgca ggagatctac caggagctga ctcggctgaa ggctgcagtg 540 ggtgagcttc cagagaaatc taagcagcag gagatctacc aggagctgac ccggctgaag 600 gctgcagtgg gtgagcttcc agagaaatct aagcagcagg agatctacca ggagctgacc 660 cggctgaagg ctgcagtggg tgagcttcca gagaaatcta agcagcagga gatctaccag 720 gagctgaccc agctgaaggc tgcagtggaa cgcctgtgcc acccctgtcc ctgggaatgg 780 acattcttcc aaggaaactg ttacttcatg tctaactccc agcggaactg gcacgactcc 840 atcaccgcct gcaaagaagt gggggcccag ctcgtcgtaa tcaaaagtgc tgaggagcag 900 aacttcctac agctgcagtc ttccagaagt aaccgcttca cctggatggg actttcagat 960 ctaaatcagg aaggcacgtg gcaatgggtg gacggctcac ctctgttgcc cagcttcaag 1020 cagtattgga acagaggaga gcccaacaac gttggggagg aagactgcgc ggaatttagt 1080 ggcaatggct ggaacgacga caaatgtaat cttgccaaat tctggatctg caaaaagtcc 1140 gcagcctcct gctccaggga tgaagaacag tttctttctc cagcccctgc caccccaaac 1200 ccccctcctg cgtag 1215 <210〉 3 <211> 344 <212> PRT <213>人工序列 <220> <223> 可溶性 DC-SIGN-1 <400〉 3ctgacccagc ttaaagctgc agtgggtgag ctctcagaga aatccaagct gcaggagatc 300 taccaggagc tgacccagct gaaggctgca gtgggtgagc ttccagagaa atctaagctg 360 caggagatct accaggagct gacccggctg aaggctgcag tgggtgagct tccagagaaa 420 tctaagctgc aggagatcta ccaggagctg acctggctga aggctgcagt gggtgagctt 480 ccagagaaat ctaagatgca ggagatctac caggagctga ctcggctgaa ggctgcagtg 540 ggtgagcttc cagagaaatc taagcagcag gagatctacc aggagctgac ccggctgaag 600 gctgcagtgg gtgagcttcc agagaaatct aagcagcagg agatctacca ggagctgacc 660 cggctgaagg ctgcagtggg tgagcttcca gagaaatcta agcagcagga gatctaccag 720 gagctgaccc agctgaaggc tgcagtggaa cgcctgtgcc acccctgtcc ctgggaatgg 780 acattcttcc aaggaaactg ttacttcatg tctaactccc agcggaactg gcacgactcc 840 atcaccgcct gcaaagaagt gggggcccag ctcgtcgtaa tcaaaagtgc tgaggagcag 900 aacttcctac agctgcagtc ttccagaagt aaccgcttca cctggatggg actttcagat 960 ctaaatcagg aaggcacgtg gcaatgggtg gacggctcac ctctgttgcc cagcttcaag 1020 cagtattgga acagaggaga gcccaacaac gttggggagg aagactgcgc ggaatttagt 1080 ggcaatggct ggaacga Cga caaatgtaat cttgccaaat tctggatctg caaaaagtcc 1140 gcagcctcct gctccaggga tgaagaacag tttctttctc cagcccctgc caccccaaac 1200 ccccctcctg cgtag 1215 <210> 3 <211> 344 <212> PRT <213>Artificial sequence<220><223> Soluble DC-SIGN- 1 <400〉 3

Ser Lys Val Pro Ser Ser lie Ser Gin Glu Gin Ser Arg Gin Asp Ala 第4頁 1337869 71464-l.ST25.txt 5 10 15 lie Tyr Gin Asn Leu Thr Gin Leu Lys Ala Ala Val Gly Glu Leu Ser 20 25 30Ser Lys Val Pro Ser Ser lie Ser Gin Glu Gin Ser Arg Gin Asp Ala Page 4 1337869 71464-l.ST25.txt 5 10 15 lie Tyr Gin Asn Leu Thr Gin Leu Lys Ala Ala Val Gly Glu Leu Ser 20 25 30

Glu Lys Ser Lys Leu Gin Glu lie Tyr Gin Glu Leu Thr Gin Leu Lys 35 40 45Glu Lys Ser Lys Leu Gin Glu lie Tyr Gin Glu Leu Thr Gin Leu Lys 35 40 45

Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gin Glu lie Tyr 50 55 60Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gin Glu lie Tyr 50 55 60

Gin Glu Leu Thr Arg Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys 65 70 75 80Gin Glu Leu Thr Arg Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys 65 70 75 80

Ser Lys Leu Gin Glu lie Tyr Gin Glu Leu Thr Trp Leu Lys Ala Ala 85 90 95Ser Lys Leu Gin Glu lie Tyr Gin Glu Leu Thr Trp Leu Lys Ala Ala 85 90 95

Val Gly Glu Leu Pro Glu Lys Ser Lys Met Gin Glu lie Tyr Gin Glu 100 105 110Val Gly Glu Leu Pro Glu Lys Ser Lys Met Gin Glu lie Tyr Gin Glu 100 105 110

Leu Thr Arg Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Π5 120 125Leu Thr Arg Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Π5 120 125

Gin Gin Glu lie Tyr Gin Glu Leu Thr Arg Leu Lys Ala Ala Val Gly 130 135 140Gin Gin Glu lie Tyr Gin Glu Leu Thr Arg Leu Lys Ala Ala Val Gly 130 135 140

Glu Leu Pro Glu Lys Ser Lys Gin Gin Glu lie Tyr Gin Glu Leu Thr 145 150 155 160Glu Leu Pro Glu Lys Ser Lys Gin Gin Glu lie Tyr Gin Glu Leu Thr 145 150 155 160

Arg Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Gin Gin 165 170 175Arg Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Gin Gin 165 170 175

Glu lie Tyr Gin Glu Leu Thr Gin Leu Lys Ala Ala Val Glu Arg Leu 180 185 190 第5頁 1337869 71464-l.ST25.txtGlu lie Tyr Gin Glu Leu Thr Gin Leu Lys Ala Ala Val Glu Arg Leu 180 185 190 Page 5 1337869 71464-l.ST25.txt

Cys His Pro Cys Pro Trp Glu Trp Thr Phe Phe Gin Gly Asn Cys Tyr 195 200 205Cys His Pro Cys Pro Trp Glu Trp Thr Phe Phe Gin Gly Asn Cys Tyr 195 200 205

Phe Met Ser Asn Ser Gin Arg Asn Trp His Asp Ser lie Thr Ala Cys 210 215 220Phe Met Ser Asn Ser Gin Arg Asn Trp His Asp Ser lie Thr Ala Cys 210 215 220

Lys Glu Val Gly Ala Gin Leu Val Val lie Lys Ser Ala Glu Glu Gin 225 230 235 240Lys Glu Val Gly Ala Gin Leu Val Val lie Lys Ser Ala Glu Glu Gin 225 230 235 240

Asn Phe Leu Gin Leu Gin Ser Ser Arg Ser Asn Arg Phe Thr Trp Met 245 250 255Asn Phe Leu Gin Leu Gin Ser Ser Arg Ser Asn Arg Phe Thr Trp Met 245 250 255

Gly Leu Ser Asp Leu Asn Gin Glu Gly Thr Trp Gin Trp Val Asp Gly 260 265 270Gly Leu Ser Asp Leu Asn Gin Glu Gly Thr Trp Gin Trp Val Asp Gly 260 265 270

Ser Pro Leu Leu Pro Ser Phe Lys Gin Tyr Trp Asn Arg Gly Glu Pro 275 280 285Ser Pro Leu Leu Pro Ser Phe Lys Gin Tyr Trp Asn Arg Gly Glu Pro 275 280 285

Asn Asn Val Gly Glu Glu Asp Cys Ala Glu Phe Ser Gly Asn Gly Trp 290 295 300Asn Asn Val Gly Glu Glu Asp Cys Ala Glu Phe Ser Gly Asn Gly Trp 290 295 300

Asn Asp Asp Lys Cys Asn Leu Ala Lys Phe Trp lie Cys Lys Lys Ser 305 310 315 320Asn Asp Asp Lys Cys Asn Leu Ala Lys Phe Trp lie Cys Lys Lys Ser 305 310 315 320

Ala Ala Ser Cys Ser Arg Asp Glu Glu Gin Phe Leu Ser Pro Ala Pro 325 330 335Ala Ala Ser Cys Ser Arg Asp Glu Glu Gin Phe Leu Ser Pro Ala Pro 325 330 335

Ala Thr Pro Asn Pro Pro Pro Ala 340 <210> 4 <211> 1035 <212> DNA <213>人工序列 第6頁 1337869 71464-l.ST25.txt <220〉 · <223〉可溶性 DC-SIGN-2 <400〉 4 tccaaggtcc ccagctccat aagtcaggaa caatccaggc aagacgcgat ctaccagaac 60 ctgacccagc ttaaagctgc agtgggtgag ctctcagaga aatccaagct gcaggagatc 120 taccaggagc tgacccagct gaaggctgca gtgggtgagc ttccagagaa atctaagctg 180 caggagatct accaggagct gacccggctg aaggctgcag tgggtgagct tccagagaaa 240 tctaagctgc aggagatcta ccaggagctg acctggctga aggctgcagt gggtgagctt 300 ccagagaaat ctaagatgca ggagatctac caggagctga ctcggctgaa ggctgcagtg 360 ggtgagcttc cagagaaatc taagcagcag gagatctacc aggagctgac ccggctgaag 420 gctgcagtgg gtgagcttcc agagaaatct aagcagcagg agatctacca ggagctgacc 480 cggctgaagg ctgcagtggg tgagcttcca gagaaatcta agcagcagga gatctaccag 540 gagctgaccc agctgaaggc tgcagtggaa cgcctgtgcc acccctgtcc ctgggaatgg 600 acattcttcc aaggaaactg ttacttcatg tctaactccc agcggaactg gcacgactcc 660 atcaccgcct gcaaagaagt gggggcccag ctcgtcgtaa tcaaaagtgc tgaggagcag 720 aacttcctac agctgcagtc ttccagaagt aaccgcttea cctggatggg aetttcagat 780 ctaaatcagg aaggcacgtg gcaatgggtg gacggctcac ctctgttgcc cagcttcaag 840 cagtattgga acagaggaga gcccaacaac gttggggagg aagactgcgc ggaatttagt 900 ggcaatggct ggaaegaega caaatgtaat cttgccaaat tctggatctg caaaaagtcc 960 gcagcctcct gctccaggga tgaagaacag tttctttctc cagcccctgc caccccaaac 1020 ccccctcctg cgtag 1035 <210〉 5 <211> 1193 <212> DNA <213>人工序列 第7頁 1337869 71464-l.ST25.txt <220〉 · <223>豬的CILA4訊號肽序列-可溶性DC-SIGN-2 <400> 5 aagcttacta gtccgccatg gcttgttctg gactccggag ccatggggct tggctggagc 60 ttacttctag gacctggccc tgtacagctc tgttttctct tctcttcatc cctgtcttct 120 ccaaagaatt ccatcaccac catcaccacg gtggcgggtc caaggtcccc agctccataa 180 gtcaggaaca atccaggcaa gacgcgatct accagaacct gacccagctt aaagctgcag 240 tgggtgagct ctcagagaaa tccaagctgc aggagatcta ccaggagctg acccagctga 300 aggctgcagt gggtgagctt ccagagaaat ctaagctgca ggagatctac caggagctga 360 cccggctgaa ggctgcagtg ggtgagcttc cagagaaatc taagctgcag gagatctacc 420 aggagctgac ctggctgaag gctgcagtgg gtgagcttcc agagaaatct aagatgcagg 480 agatctacca ggagctgact cggctgaagg ctgcagtggg tgagcttcca gagaaatcta 540 agcagcagga gatctaccag gagctgaccc ggctgaaggc tgcagtgggt gagcttccag 600 agaaatctaa gcagcaggag atctaccagg agctgacccg gctgaaggct gcagtgggtg 660 agcttccaga gaaatctaag cagcaggaga tctaccagga gctgacccag ctgaaggctg 720 cagtggaacg cctgtgccac ccctgtccct gggaatggac attcttccaa ggaaactgtt 780 acttcatgtc taactcccag cggaactggc acgactccat caccgcctgc aaagaagtgg 840 gggcccagct cgtcgtaatc aaaagtgctg aggagcagaa cttcctacag ctgcagtctt 900 ccagaagtaa ccgcttcacc tggatgggac tttcagatct aaatcaggaa ggcacgtggc 960 aateggtgga cggctcacct ctgttgccca gettcaagca gtattggaac agaggagage 1020 ccaacaacgt tggggaggaa gactgcgcgg aatttagtgg caatggctgg aacgacgaca 1080 aatgtaatct tgccaaattc tggatctgca aaaagtccgc agcctcctgc tccagggatg 1140 aagaacagtt tctttctcca gcccctgcca ccccaaaccc ccctcctgcg tag 1193 <210〉 6 第8頁 1337869 71464-l.ST25.txt <211> 1141 ·Ala Thr Pro Asn Pro Pro Pro Ala 340 <210> 4 <211> 1035 <212> DNA <213> Artificial Sequence Page 6 1337869 71464-l.ST25.txt <220> · <223> soluble DC-SIGN-2 < 400> 4 tccaaggtcc ccagctccat aagtcaggaa caatccaggc aagacgcgat ctaccagaac 60 ctgacccagc ttaaagctgc agtgggtgag ctctcagaga aatccaagct gcaggagatc 120 taccaggagc tgacccagct gaaggctgca gtgggtgagc ttccagagaa atctaagctg 180 caggagatct accaggagct gacccggctg aaggctgcag tgggtgagct tccagagaaa 240 tctaagctgc aggagatcta ccaggagctg acctggctga aggctgcagt gggtgagctt 300 ccagagaaat ctaagatgca ggagatctac caggagctga ctcggctgaa ggctgcagtg 360 ggtgagcttc cagagaaatc taagcagcag gagatctacc aggagctgac ccggctgaag 420 gctgcagtgg gtgagcttcc agagaaatct aagcagcagg agatctacca ggagctgacc 480 cggctgaagg ctgcagtggg tgagcttcca gagaaatcta agcagcagga gatctaccag 540 gagctgaccc agctgaaggc tgcagtggaa cgcctgtgcc acccctgtcc ctgggaatgg 600 acattcttcc aaggaaactg ttacttcatg tctaactccc agcggaactg gcacgactcc 660 atcaccgcct gcaaagaagt gggggcccag c tcgtcgtaa tcaaaagtgc tgaggagcag 720 aacttcctac agctgcagtc ttccagaagt aaccgcttea cctggatggg aetttcagat 780 ctaaatcagg aaggcacgtg gcaatgggtg gacggctcac ctctgttgcc cagcttcaag 840 cagtattgga acagaggaga gcccaacaac gttggggagg aagactgcgc ggaatttagt 900 ggcaatggct ggaaegaega caaatgtaat cttgccaaat tctggatctg caaaaagtcc 960 gcagcctcct gctccaggga tgaagaacag tttctttctc cagcccctgc caccccaaac 1020 ccccctcctg cgtag 1035 < 210> 5 < 211 & gt 1193 <212> DNA <213> Artificial Sequence Page 7 1337869 71464-l.ST25.txt <220> · <223> Pig CILA4 Signal Peptide Sequence - Soluble DC-SIGN-2 <400> 5 aagcttacta gtccgccatg gcttgttctg gactccggag ccatggggct tggctggagc 60 ttacttctag gacctggccc tgtacagctc tgttttctct tctcttcatc cctgtcttct 120 ccaaagaatt ccatcaccac catcaccacg gtggcgggtc caaggtcccc agctccataa 180 gtcaggaaca atccaggcaa gacgcgatct accagaacct gacccagctt aaagctgcag 240 tgggtgagct ctcagagaaa tccaagctgc aggagatcta ccaggagctg acccagctga 300 aggctgcagt gggtgagctt ccagagaaat ctaagctgca ggagatctac caggagctga 360 cccggctgaa ggctgcagtg ggtgagcttc cagagaaatc taagctgcag gagatctacc 420 aggagctgac ctggctgaag gctgcagtgg gtgagcttcc agagaaatct aagatgcagg 480 agatctacca ggagctgact cggctgaagg ctgcagtggg tgagcttcca gagaaatcta 540 agcagcagga gatctaccag gagctgaccc ggctgaaggc tgcagtgggt gagcttccag 600 agaaatctaa gcagcaggag atctaccagg agctgacccg gctgaaggct gcagtgggtg 660 agcttccaga gaaatctaag cagcaggaga tctaccagga gctgacccag ctgaaggctg 720 cagtggaacg cctgtgccac ccctgtccct gggaatggac attcttccaa ggaaactgtt 780 acttcatgtc taactcccag cggaactggc acgactccat caccgcctgc aaagaagtgg 840 gggcccagct cgtcgtaatc aaaagtgctg aggagcagaa cttcctacag ctgcagtctt 900 ccagaagtaa ccgcttcacc tggatgggac tttcagatct aaatcaggaa ggcacgtggc 960 aateggtgga cggctcacct ctgttgccca gettcaagca gtattggaac agaggagage 1020 ccaacaacgt tggggaggaa gactgcgcgg aatttagtgg caatggctgg aacgacgaca 1080 aatgtaatct tgccaaattc tggatctgca aaaagtccgc agcctcctgc tccagggatg 1140 aagaacagtt tctttctcca gcccctgcca ccccaaaccc ccctcctgcg tag 1193 <210 〉 6 Page 8 1337869 71464-l.ST25.txt <211> 1141 ·

<212> DNA <213>人工序列 ‘ <220〉 <223>老鼠的I gk -鏈V-〗2 - C訊號肽序列-可溶性 DC-SIGN-2 <400〉 6 gctagccacc atggagacag acacactcct gctatgggta ctgctgctct gggttccagg 60 ttccactggt gacgcggccc atcaccacca tcaccacggt ggcgggtcca aggtccccag 120 ctccataagt caggaacaat ccaggcaaga cgcgatctac cagaacctga cccagct taa 180 agctgcagtg ggtgagctct cagagaaatc caagctgcag gagatctacc aggagetgae 240 ccagctgaag gctgcagtgg gtgagcttcc agagaaatet aagctgcagg agatctacca 300 ggagctgacc cggctgaagg ctgcagtggg tgagcttcca gagaaateta agctgcagga 360 gatctaccag gagctgacct ggctgaaggc tgcagtgggt gagcttccag agaaatctaa 420 gatgcaggag atctaccagg agctgactcg getgaagget gcagtgggtg agcttccaga 480 gaaatctaag cagcaggaga tctaccagga gctgacccgg ctgaaggctg cagtgggtga 540 gcttccagag aaatctaagc agcaggagat ctaccaggag ctgacccggc tgaaggctgc 600 agtgggtgag ct tccagaga aatctaagca gcaggagatc taccaggagc tgacccagct 660 gaaggctgca gtggaacgcc tgtgccaccc ctgtccctgg gaatggacat tet tccaagg 720 aaactgttac ttcatgtcta actcccagcg gaactggcac gactccatca ccgcctgcaa 780 agaagtgggg gcccagctcg tcgtaatcaa aagtgctgag gagcagaact tcctacagct 840 gcagtcttcc agaagtaacc get tcacctg gatgggactt teagatetaa atcaggaagg 900 cacgtggcaa tgggtggacg gctcacctct gt tgcccagc t tcaagcagt at tggaacag 960 aggagagccc aacaacgttg gggaggaaga ctgcgcggaa tttagtggca atggctggaa 1020 cgacgacaaa tgtaatcttg ccaaattctg gatctgcaaa aagtccgcag cctcctgctc 1080 caeggatgaa gaacagtttc tt tctccagc ccctgccacc ccaaaccccc ctcctgcgta 1140<212> DNA <213>Artificial sequence ' <220> <223> Igk-chain V- 2 of the mouse - C signal peptide sequence - soluble DC-SIGN-2 <400> 6 gctagccacc atggagacag acacactcct gctatgggta ctgctgctct gggttccagg 60 ttccactggt gacgcggccc atcaccacca tcaccacggt ggcgggtcca aggtccccag 120 ctccataagt caggaacaat ccaggcaaga cgcgatctac cagaacctga cccagct taa 180 agctgcagtg ggtgagctct cagagaaatc caagctgcag gagatctacc aggagetgae 240 ccagctgaag gctgcagtgg gtgagcttcc agagaaatet aagctgcagg agatctacca 300 ggagctgacc cggctgaagg ctgcagtggg tgagcttcca gagaaateta agctgcagga 360 gatctaccag gagctgacct ggctgaaggc tgcagtgggt gagcttccag agaaatctaa 420 gatgcaggag atctaccagg agctgactcg getgaagget gcagtgggtg agcttccaga 480 gaaatctaag cagcaggaga tctaccagga gctgacccgg ctgaaggctg cagtgggtga 540 gcttccagag aaatctaagc agcaggagat ctaccaggag ctgacccggc tgaaggctgc 600 agtgggtgag ct tccagaga aatctaagca gcaggagatc taccaggagc tgacccagct 660 gaaggctgca gtggaacgcc tgtgccaccc ctgtccctgg gaatggacat tet tccaagg 720 aaa ctgttac ttcatgtcta actcccagcg gaactggcac gactccatca ccgcctgcaa 780 agaagtgggg gcccagctcg tcgtaatcaa aagtgctgag gagcagaact tcctacagct 840 gcagtcttcc agaagtaacc get tcacctg gatgggactt teagatetaa atcaggaagg 900 cacgtggcaa tgggtggacg gctcacctct gt tgcccagc t tcaagcagt at tggaacag 960 aggagagccc aacaacgttg gggaggaaga ctgcgcggaa tttagtggca atggctggaa 1020 cgacgacaaa tgtaatcttg ccaaattctg gatctgcaaa aagtccgcag cctcctgctc 1080 caeggatgaa gaacagtttc tt tctccagc Ccctgccacc ccaaaccccc ctcctgcgta 1140

第9頁 1337869 71464-l.ST25.txt g 1141 第10頁Page 9 1337869 71464-l.ST25.txt g 1141 Page 10

Claims (1)

13378691337869 及醫藥上可接受之載劑、 〇 ^ dendritic cell-specific ICAM-3 DC_SIGN)或其生物功能等效物，以 射、賦形劑或稀釋劑，其中該DC- SIGN生物功能等效物為部分Dc_sIgN。 2 .如申請專利範圍第1項所述之醫藥組成物，其中 該DC-SIGN生物功能等效物為DC SIGN四聚體。 3 ·如申請專利範圍第2項所述之醫藥組成物，其中< 該DC-SIGN生物功能等效物為可溶性。 4 .如申請專利範圍第2項所述之醫藥組成物，其中 該DC-SIGN生物功能等效物之核苷酸序列為seq 2 ύ 5 ’如申請專利範圍第2項所述之醫藥組成物，其中 該DC-SIGN生物功能等效物之核苷酸序列為SEq出Ν〇 4 ο 6 .如申請專利範圍第2項所述之醫藥組成物，其中 該DC-SIGN生物功能等效物之核苷酸序列為seq id n〇 $ ο 7 ·如申請專利範圍第2項所述之醫藥組成物，其中 該DC-SIGN生物功能等效物之核苷酸序列為seq IQ 6 ο 8 .如申請專利範圍第4至7項任—項所述之醫藥組 17 1337869 成物，其中該DC-SIGN生举；功能等效物之胺基酸序列為 SEQ ID N0.3。 9 . 一種清潔用品，其中包括DC-SIGN或其生物功能 等效物。 1 0 .如申請專利範圍第9項所述之清潔用品，其中 該DC-SIGN生物功成等效物為部分dc_§ign。 1 1 .如申請專利範圍第9或丄〇項所述之清潔用品 ’其中該DC-SIGN生物功能等效物為dc-SIGN四聚體。 1 2 .如申請專利範圍第1 i項所述之清潔用品，其 中該DC-SIGN生物功能等效物為可溶性。 1 3 .如申請專利範圍第i i項所述之清潔用品，其 中該DC-SIGN生物功能等效物之核苷酸序列為seq id N0.2。 14.如申請專利範圍第1丄項所述之清潔用品其 中該DC-SIGN生物功能等效物之核苷酸序列為seq ι〇 NO.4。 .如申請專利範圍第丄丄項所述之清潔用品其 中該DC-SIGN生物功能等效物之核脊酸序列為卿⑴ N0.5。 項所述之清潔用品，其 核苦酸序列為SEQ ID 1 6 .如申請專利範圍第1 1 中該DC-SIGN生物功能等效物之 N0.6。 17 清潔用品 如申請專利範圍第1 3 其中該DC-SIGN生物功 至1 6項任一項所述之 能等效物之胺基酸序列 18 1337869 為 SEQ ID N0.3。 拾壹、圖式： 如次頁 19 1337869 柒、指定代表圖： (一) 本案指定代表圖為：第（一）圖。 (二) 本代表圖之元件代表符號簡單說明： 無 捌、本案若有化學式時，請揭示最能顯示發明特徵的化學式And a pharmaceutically acceptable carrier, den^ dendritic cell-specific ICAM-3 DC_SIGN) or a biologically functional equivalent thereof, in the form of a shot, an excipient or a diluent, wherein the DC- SIGN biofunctional equivalent is a portion Dc_sIgN. 2. The pharmaceutical composition of claim 1, wherein the DC-SIGN biologically functional equivalent is a DC SIGN tetramer. 3. The pharmaceutical composition according to claim 2, wherein < the DC-SIGN biologically functional equivalent is soluble. 4. The pharmaceutical composition according to claim 2, wherein the nucleotide sequence of the DC-SIGN biologically functional equivalent is seq 2 ύ 5 ', as described in claim 2, the pharmaceutical composition , wherein the nucleotide sequence of the DC-SIGN biologically functional equivalent is the SEq Ν〇4 ο 6 . The pharmaceutical composition according to claim 2, wherein the DC-SIGN biological functional equivalent The nucleotide sequence is seq id n〇$ ο 7 . The pharmaceutical composition according to claim 2, wherein the nucleotide sequence of the DC-SIGN biologically functional equivalent is seq IQ 6 ο 8 . The pharmaceutical group 17 1337869 according to any one of claims 4 to 7 wherein the DC-SIGN is produced; the amino acid sequence of the functional equivalent is SEQ ID N0.3. 9. A cleaning article comprising DC-SIGN or a biologically functional equivalent thereof. The cleaning article of claim 9, wherein the DC-SIGN bio-equivalent is part dc_§ign. 1 1. A cleaning article as claimed in claim 9 or wherein the DC-SIGN biofunctional equivalent is a dc-SIGN tetramer. The cleaning article of claim 1, wherein the DC-SIGN biologically functional equivalent is soluble. A cleaning article according to the invention of claim i, wherein the nucleotide sequence of the DC-SIGN biologically functional equivalent is seq id N0.2. 14. The cleaning product of claim 1, wherein the nucleotide sequence of the DC-SIGN biologically functional equivalent is seq ι〇 NO. The cleaning product according to the invention of claim 2, wherein the DC-SIGN biological functional equivalent of the nuclear choric acid sequence is qing (1) N0.5. The cleaning product of the present invention has a nucleotide sequence of SEQ ID 166. N0.6 of the DC-SIGN biologically functional equivalent of claim 1 of the patent application. 17 Cleaning Articles The amino acid sequence 18 1337869 wherein the DC-SIGN biologic to any of the energy equivalents described in any one of the sixteen items is SEQ ID N0.3. Pickup, drawing: For example, page 19 1337869 柒, designated representative map: (1) The representative representative of the case is: (1). (2) A brief description of the symbol of the symbol of the representative figure: None. If there is a chemical formula in this case, please reveal the chemical formula that best shows the characteristics of the invention.
TW93105277A 2004-03-01 2004-03-01 Pharmaceutical composition and cleansing reagent comprising dendritic cell-specific icam-3 grabbing nonintegrin (dc-sign) and use thereof TWI337869B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
TW93105277A TWI337869B (en) 2004-03-01 2004-03-01 Pharmaceutical composition and cleansing reagent comprising dendritic cell-specific icam-3 grabbing nonintegrin (dc-sign) and use thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
TW93105277A TWI337869B (en) 2004-03-01 2004-03-01 Pharmaceutical composition and cleansing reagent comprising dendritic cell-specific icam-3 grabbing nonintegrin (dc-sign) and use thereof

Publications (2)

Publication Number Publication Date
TW200529867A TW200529867A (en) 2005-09-16
TWI337869B true TWI337869B (en) 2011-03-01

Family

ID=45074710

Family Applications (1)

Application Number Title Priority Date Filing Date
TW93105277A TWI337869B (en) 2004-03-01 2004-03-01 Pharmaceutical composition and cleansing reagent comprising dendritic cell-specific icam-3 grabbing nonintegrin (dc-sign) and use thereof

Country Status (1)

Country Link
TW (1) TWI337869B (en)

Also Published As

Publication number Publication date
TW200529867A (en) 2005-09-16

Similar Documents

Publication Publication Date Title
US10435676B2 (en) Variants of terminal deoxynucleotidyl transferase and uses thereof
Kruijer et al. Structure and organization of the gene coding for the DNA binding protein of adenovirus type 5
JP4541712B2 (en) Oligonucleotides originating from sequences encoding the surface components of PTLV envelope proteins and their use
ES2887078T3 (en) Engineered Ligase Variants
Haire et al. TXK, a novel human tyrosine kinase expressed in T cells shares sequence identity with Tec family kinases and maps to 4p12
JPH10503759A (en) Linked peptide nucleic acid
TW200951219A (en) An improved SUMO fusion protein system for effective production of native proteins
JPH11502416A (en) Viral substances and nucleotide fragments involved in multiple sclerosis for diagnosis, prevention and treatment
CN109072203B (en) Mirror image nucleic acid replication system
US11390856B2 (en) Variants of family a DNA polymerase and uses thereof
JP2003524387A5 (en)
Felder et al. Tas, a retrotransposon from the parasitic nematode Ascaris lumbricoides
TWI337869B (en) Pharmaceutical composition and cleansing reagent comprising dendritic cell-specific icam-3 grabbing nonintegrin (dc-sign) and use thereof
WO1995027057A1 (en) GENE CODING FOR IgG-Fc-BINDING PROTEIN
Nguyen et al. Suppressive subtractive hybridization of and differences in gene expression content of calcifying and noncalcifying cultures of Emiliania huxleyi strain 1516
KR102043356B1 (en) Lignin degrading enzymes from Macrophomina phaseolina and uses thereof
JP4158956B2 (en) Method for producing gene encoding protein having ability to regenerate luciferin, recombinant DNA and protein having ability to regenerate luciferin
JPH10276782A (en) Gene for cellulose-synthesizing enzyme
Cheney et al. Molecular characterization of the segment 2 gene of epizootic hemorrhagic disease virus serotype 2: gene sequence and genetic diversity
CN102108359A (en) Gene-modified peste des petits ruminants N gene and modification method and chemical synthesis thereof
ES2588245T3 (en) Ulvano liasa, manufacturing procedure and uses
AU8989598A (en) Oligonucleotides for identifying precursors of amidated polypeptide hormones
EP0506977A1 (en) Method of detecting non-a non-b hepatitis specific gene and reagent composition used therefor
Akaberi et al. Identification of unique and potent inhibitors of SARS-CoV-2 main protease from DNA-encoded chemical libraries
CA2326699A1 (en) Gene 62 of oka vaccine virus and method for identifying virus strain for live attenuated vaccine virus using the gene 62

Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees