TWI328444B - - Google Patents

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TWI328444B
TWI328444B TW96128310A TW96128310A TWI328444B TW I328444 B TWI328444 B TW I328444B TW 96128310 A TW96128310 A TW 96128310A TW 96128310 A TW96128310 A TW 96128310A TW I328444 B TWI328444 B TW I328444B
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Taiwan
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light
treatment
electrically connected
diagnosis
signal
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TW96128310A
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Chinese (zh)
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TW200906370A (en
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Shyh Liang Lou
Tzong Rong Ger
Yih Chih Hsu
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Shyh Liang Lou
Tzong Rong Ger
Yih Chih Hsu
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Description

1328444 九、發明說明: “【發明所屬之技術領域】 本發明係有關於一種感應裝置,特別是有關於一種應用於光 動力診斷與治療之感應裝置。 • 【先前技術】 隨者醫療科技及技術的快速發展,光動力療法 therapy ’ PDT)是一種突破傳統癌腫瘤治療方式的先進技術。配合 鲁傳統外科手術切除腫瘤的猶’光動力治療係於大部分的紐瘤 切除後’再對剩餘的腫瘤細胞加以消滅,以達到最佳的治療效果。 由於光動力療法具有對患者人體的侵害性小、避免患者免疫功能 的失調、患者於療程過後恢復迅速、可選擇性殺死腫瘤細胞,而 不傷害到正常細胞等優點,已成為近年來備受矚目的醫療技術之 —-〇 ~ ·光動力療法縣對患者注射或是·級錢劑,並給予一 時間讓光敏感藥劑附著於腫瘤細胞上,再藉由光照射襄置發出 特疋波長的光線,以激發光敏感藥劑產生一光活化反應,引發 : 腫瘤細月包毒性,進而消滅腫瘤細胞。 習用之光動力療法受限於絲力騎裝置之光源穿透力不 ^因此多半用於人體表層器官的治療上,例如皮膚癌、口腔癌 、病症照㈣置係直接照射於人體患部,以賴;肖滅腫瘤細胞 的治療效果。 近年來,光動力療法亦開始應用於人體較為深層的器官組 織。以腦顯治療為例,患者在進行外科手術關時,會將生物 1328444 至生物相容材料内,以 ,克服了傳統光動力裝 相容材料一併植入顱腔内,並導入一光纖 對顱腔内殘留的腫瘤細胞進行光照射治療 置無法針對顱内腫瘤進行治療的限制。 但對於患者而言,藉由外露於頭部的光纖進行顧内 ' 照射,係屬於侵入式的治療方式,長期的治療過程,對於串者^ . 生理或是心理上都是極大的負擔,不僅對患者的平日生活^成2 當多的不便外,更存在有顱腔容易遭受細菌感染的危險性^成相 • 為了減少患者於長時間治療的不便及所產生的副作用,習 光動=射裝置之光源多半會採用高光功率之發光元件,如雷射 等高能量的發规,而大幅縮短絲射療程所需的時間,以^緩 患者的不適感與細菌感染的風險。 然而,於近年發表的相關研究報告顯示,以高光功率、短時 間之光動力治射式,所得_療效並不如以低光轉持續照射 〜拍轉效果。就目前的轴力治療技摘言,是無法兼具串 •者於治療過程中的安全性及舒適性,並且同時獲得健的治療 . 效0 ; 【發明内容】 '蓉於以上關題’本發明提供—種應用於光動力診斷與治療 之感應裝置,藉以改良先前技術之光動力黯裝置無法進行人體 體内的疾病診斷’且習用光動力照射裝置必須露出於人體 外之光纖導線’造成患者於治療期間_不適與不便,以及習用 光動力治療無關時兼具患者身叫諸,贿 口 π 风从 1328444 本發明簡露之顧於轴力賴與絲的絲裝置,係使 .用於生物的冶療上’以激發注射於生物體内之光敏感藥劑產生光 化學反應。感應裝置包括有一發射器,及-可被植入生物體内的 光照射器,光騎H具有-第—感應、_、—祕連接於第一感 ••應線圈之控制電路、及-電性連接於控㈣路之發光元件。〜 魏H用赠出_穿透生物表層之無線訊號,光照射器之第 -感應線圈接收無線訊號後,藉由控制電路將無線訊號轉換為一 _驅動職’令贱讀發&—波長匹配於絲感藥歡光線,以 使光敏感藥劑產生光化學反應。 本發明之功效在於,位於生物體外之發射器藉由無線能量傳 輸方式,以電磁感應設置於生物體内之光照射器發出—光線,而 激發先敏感樂繼生反應,以進行生物體姆斷或是治療。本發 以及平日生 =峨,綱跑嫩絲恤触佳治療效果 明不僅改善了贿_輸枝断絲之料絲力治療裝置7 於治療期間對生物體所產生的各種副作用、不適感 、1328444 IX. Description of the invention: "Technical field to which the invention pertains" The present invention relates to an inductive device, and more particularly to an inductive device for use in photodynamic diagnosis and treatment. [Prior Art] Medical technology and technology The rapid development of photodynamic therapy 'PDT' is an advanced technology that breaks through the traditional treatment of cancerous cancer. The traditional 'surgical resection of tumors with Lu's traditional surgical resection of the tumor after most of the tumor resection' The tumor cells are eliminated to achieve the best therapeutic effect. Since photodynamic therapy has less invasiveness to the patient's human body, avoids the imbalance of the patient's immune function, the patient recovers rapidly after the treatment, and can selectively kill the tumor cells without Injury to normal cells and other advantages, has become a high-profile medical technology in recent years - 〇 ~ · Photodynamic therapy county injection of patients or drugs, and give a time for light-sensitive agents to attach to tumor cells And emitting light of a special wavelength by means of light irradiation to excite the light-sensitive agent to generate a light The reaction, triggering: the toxicity of the tumor and the elimination of tumor cells. The conventional photodynamic therapy is limited by the light penetration of the silk force riding device, so it is mostly used for the treatment of human surface organs, such as skin cancer. Oral cancer, disease photo (4) is directly exposed to the affected part of the human body, to rely on; the treatment effect of tumor cells. In recent years, photodynamic therapy has also begun to be applied to the deeper organs of the human body. Take brain therapy as an example, patients During the surgical closure, the organism 1328444 will be implanted into the biocompatible material to overcome the traditional photodynamic loading compatible material and implanted into the cranial cavity, and an optical fiber is introduced to irradiate the residual tumor cells in the cranial cavity. Treatment is not limited to the treatment of intracranial tumors. However, for patients, the use of optical fibers exposed to the head for internal irradiation is an invasive treatment, long-term treatment process, for the string. Physically or psychologically, it is a great burden, not only for the patient's normal life, but also because of the inconvenience, there is a cranial cavity that is susceptible to bacteria. Danger of dyeing ^ phase formation · In order to reduce the inconvenience and side effects of long-term treatment, the light source of the light-emitting device will mostly use high-light power components, such as lasers and other high-energy hair gauges. And significantly shorten the time required for silk therapy to reduce the patient's discomfort and the risk of bacterial infection. However, the relevant research report published in recent years shows that with high optical power, short-time photodynamic therapy, the resulting _ The curative effect is not as good as continuous light irradiation with low light. The current axial force treatment technique is not able to combine the safety and comfort of the patient in the treatment process, and at the same time obtain a healthy treatment. [Invention] The present invention provides a sensing device for photodynamic diagnosis and treatment, which can improve the prior art photodynamic device and can not diagnose the disease in the human body. The power-illuminating device must be exposed to the fiber-optic lead outside the human body', causing the patient to have a patient's body during the treatment period _ discomfort and inconvenience, and when it is not related to conventional photodynamic therapy Calling, bribery π wind from 1328444 The invention is based on the axial force of the silk and silk device, which is used in the biological treatment of the body to stimulate the injection of light-sensitive agents injected into the organism to produce photochemistry reaction. The sensing device comprises a transmitter, and a light illuminator that can be implanted in the living body, and the light riding H has a -first sensing, a _, a secret connection to the first sense • a control circuit of the coil, and a The light-emitting element is connected to the control (four) road. ~ Wei H uses the wireless signal that penetrates the surface of the biological layer, and the first sensor coil of the light illuminator receives the wireless signal, and then converts the wireless signal into a _driver's position by the control circuit. It is matched with the silky sensation light to cause photochemical reaction of the light sensitive agent. The effect of the invention is that the emitter located outside the body emits light by means of wireless energy transmission, electromagnetically illuminating the light illuminator disposed in the living body, and exciting the sensitization of the first sensitive music to perform the biological maturation. Or treatment. This hair and the weekdays = 峨, the running of the tender silk shirt, the effect of the treatment, not only improved the bribe _ loss of broken silk material treatment device 7 various side effects, discomfort to the organism during treatment,

的功效。 以上之關於本發明内容之說明及以下之 以示範與解釋本發明之原理, Λ之說月係用 進一步之解釋。 徒供本翻之專射請範圍更 【實施方式】 根據本發明所揭1:應用於光動力 藉由無線傳輸能量之方式執行作動二=感應裝置’係 但不概於練射_iefrequeney _ @ 式包括 )或是微波傳輸等無線 1328444 傳輸技術。以下本發明的詳細說明中,將以使用1MHz&右之無 _線射頻傳輸(RF)做為本發明之最佳實施例。然而所附圖式僅提供 參考與說明用,並非用以限制本發明。 如「第1A圖」及「第1B圖」所示,本發明所揭露應用於光 動力診斷與治療之感應裝置100,係使用於一生物2〇〇上,用以 . 激發注射於生物2〇〇體内之光敏感藥劑(圖中未示)產生光化學反 應,而對生物200之細胞組織進行治療,例如惡性腫瘤、黑斑、 •皮膚美白、傷症、眼底黃斑部病變、或是顯影標示特定細胞組織 等用以針對不良細胞之治療方式。 值得注意的是,本發明於實施例中所述之感應裝置,係以治 療讀内之腫瘤細胞做為實_的制,熟悉該項技術者,可根 據實際的使用需求,而應胁各類生物制麟與絲上,並不 以本發明之實施例為限。 —本發明之感應裝置包括有—發射器則及—光照射器啊見 • 「第1B圖」)。發射器11G具有—第二感應線圈⑽,用以發出 -無線射頻訊號,且此無線賴訊號可?透過生物2⑻之表層, 例如人體的皮膚、齡、她肉等表層遞至生物曰’ 設置於生物200體内之光照射器12〇具有一第一感應線圈 12卜-電性連接第-感應線圈121之控制電路122、一電 控制電路122之發光元件123。 堤接 器110射出之無線射頻訊 號轉換為-具有電愿之驅 第一感應線圈121係用以接收發射 號,並藉由控制電路122將無線射頻訊 1328444 動訊號,以產生一電流。發光元件123可為一發光二極體或是雷 射發射器等光源產生裝置,發光元件Π3於接收驅動訊號所產生 之電流後,發出一匹配於光敏感藥劑之特定波長的光線,以激發 光敏感藥劑產生光化學反應。 本發明係以一 5-ALA(5-aminolevulinic acid)及 - hematoProPhine類之光敏感藥劑’例如為photofrin做為實施例 之說明,熟悉光動力治療之該項技術者,可根據實際的使用需 # 求,而對應使用不同的光敏感藥劑,並搭配與光敏感藥劑相匹配 之光線進行活化激發,並不以本發明之實施例為限。5_从八及 Photofrin等藥劑的較佳活化波長約為63〇nm,並搭配發光元件 123所發出之紅色光源’以激發5-ALA及Photofrin藥劑產生光 化學反應,進而治療生物200體内之腦癌、食道癌、胃腸道癌、 膀胱癌、或是肺癌等腫瘤細胞。由於5—ala光敏感藥劑具備有 毒性低、代謝快、及避光時間只f丨至2天等優點,而開始廣泛 •應用於醫療臨床的治療上。 ·_ 綠錢”難要触—定強度的能量柯餘發反應,因此 ;本發明可齡㈣發光元件⑵之光轉大小,或是光照射時間 等參數’而可精確掌握治療過程的療時’並且避免生物2〇〇因光 功率過強所產生的不適感及副作用。 凊參閱「第2圖」之發射n的電路方細。如圖所示,本發 明之發射器no包含有-驅動電路m及一震盈電路112。驅動電 路111中具有-波形產生器lm、一電性連接於波形產生器1111 之除頻1§ 1112、電性連接於除頻器1112之反向器、二電 1328444 性連接於反向器1113之調變器1114、二分別電性連接於調變器 1114之D類功率放大1115、及二分別電性連結於d類功率放 大器1115之變壓器1116。 八中波升v產生器11U係用以產生一方波’此方波透過除頻 ·‘ H 1112輕至—特定細之做解,捕由反㈣1113將調 ··整後之方波傳遞至二調變器1114中,以分別產生二反向之具有固 定波寬與振幅的方波訊號。方波訊號經由功率放大器的增益作 Φ用’而傳遞至變壓器1116内,並藉由二變壓器⑴6的轉換,使 得正波訊號分別以一正弦波與一負弦波型態之控制訊號輸出。 發射器110之震盪電路112包括有一電源112卜二電性連接 ;電原1121之電曰曰體開目1122、以及一電性連接於電晶體開關 Π22之共振電路1123,共振電路肋料-電性連接於電晶體 幵1關1122之第—感應線圈1124,及—電性連接於第二感應線圈 1124之電容U25。 難 其中’二電晶體開關1122係用以分別接收變;1器1116之控 制訊號’並相反於另一電晶體開關1122執行開啟或是關閉的動 作。電源mH罐其中—呈狀態之電晶體卿ιΐ22,而持續 導通電机至共振電路⑴3中,第二感應線圈ιΐ24藉由電容此 的充放電作用,以產生並發出一無線訊號至第一感應線圈⑵, 而形成一磁力場感應耦合。 請參閱「第3A圖」及「第3B圖」之光照射器立體示意圖盘 塊圖。光照射器120之控制電路122具有-整流器1221, 電11連接於整流H 1221與發光元件⑵之穩壓器1222。控 1328444 ··制電路122將第一感應線圈121所接收之磁性之無線訊號轉換為 電性之驅動訊號,驅動訊號透過整流器1221的作用,以將原本 又向展盪之驅動訊號轉換為單向震盈的訊號,並藉由穩壓器1222 維持一定的輸出值範圍,以避免發光元件123因驅動訊號的電壓 * 值不穩定而造成損壞。本發明揭露之整流器1221可為半波整流 • 器、全波整流器、或是橋式整流器之任一型態的整流器,然此一 技術已為熟悉該項技術之通常人士所能知悉的設計,故發明人於 φ 此不另贅敘。 請繼續參閱「第3A圖」’光照射器12〇外圍更具有一透明可 透光之包覆材料150 ’以完全包覆住第一感應線圈⑵、控制電路 122、及發光元件123。包覆材料15〇係以生物用矽膠材料或是玻 璃材料所製成,不但具有良好的生物相容性,更具備優良的絕緣 與散熱效果,避免設置於生物2〇〇體内之光照射器12〇,因運作 所產生的過高熱能造成生物2〇〇的不適感。 _ 自於光照射H 12G具備優㈣錢相雜,0此可選擇於療 •程結束後,將光照射器120自生物200體内取出;或是長期置放The effect. The above description of the present invention and the following are intended to illustrate and explain the principles of the present invention. According to the present invention, it is disclosed in the present invention that the application of the second embodiment of the invention is performed by means of wireless transmission of energy, but the operation is not performed. _iefrequeney _ @ The method includes) or wireless transmission 1328444 transmission technology such as microwave transmission. In the following detailed description of the present invention, the use of 1 MHz & right-free radio frequency transmission (RF) is the preferred embodiment of the present invention. The drawings are provided for the purpose of illustration and description only and are not intended to limit the invention. As shown in FIG. 1A and FIG. 1B, the sensing device 100 for photodynamic diagnosis and treatment disclosed in the present invention is used on a living body to stimulate injection into a living body. The photo-sensitive agent (not shown) in the sputum produces a photochemical reaction, and the cell tissue of the bacterium 200 is treated, such as malignant tumor, dark spot, skin whitening, injury, macular degeneration of the fundus, or development A specific cell tissue or the like is used to treat a treatment for an undesirable cell. It should be noted that the sensing device described in the embodiment is based on the treatment of tumor cells in the reading system. Those who are familiar with the technology can threaten various types according to actual use requirements. The biological system and the silk are not limited to the embodiment of the present invention. - The sensing device of the present invention includes a transmitter and a light illuminator (see Fig. 1B). The transmitter 11G has a second inductive coil (10) for emitting a radio frequency signal, and the wireless signal is available? Through the surface layer of the biological 2 (8), for example, the skin of the human body, the skin of the human body, the surface of her meat, etc., the light illuminator 12 disposed in the body of the living body 200 has a first induction coil 12 - electrically connected to the first induction coil The control circuit 122 of 121 and the light-emitting element 123 of an electrical control circuit 122. The radio frequency signal emitted by the bank 110 is converted into a drive with a power. The first induction coil 121 is configured to receive the transmission number, and the radio frequency signal 1328444 is transmitted by the control circuit 122 to generate a current. The light-emitting element 123 can be a light-emitting diode or a light-emitting device such as a laser emitter. After receiving the current generated by the driving signal, the light-emitting element 发出3 emits light corresponding to a specific wavelength of the light-sensitive agent to excite the light. Sensitive agents produce photochemical reactions. The invention adopts a 5-ALA (5-aminolevulinic acid) and -hematoProPhine-like light-sensitive agent, for example, photofrin as an example, and is familiar with the technique of photodynamic therapy, and can be used according to actual needs. It is not limited to the embodiment of the present invention to use a different light-sensitive agent in combination with the light that matches the light-sensitive agent for activation activation. 5_ The preferred activation wavelength of the agent such as VIII and Photofrin is about 63 〇 nm, and the red light source emitted by the illuminating element 123 is used to excite the 5-ALA and Photofrin agents to produce a photochemical reaction, thereby treating the body of the living body 200. Tumor cells such as brain cancer, esophageal cancer, gastrointestinal cancer, bladder cancer, or lung cancer. Since 5-ala light-sensitive agents have the advantages of low toxicity, fast metabolism, and light-shielding time of only 丨 to 2 days, they have been widely used in medical clinical treatment. · _ Green money is difficult to touch - the energy of the constant intensity of the co-existing reaction, therefore, the age of the (four) light-emitting element (2) of the light-emitting element, or the light irradiation time and other parameters can accurately grasp the treatment time of the treatment process 'And avoid the discomfort and side effects caused by the excessive power of the biological 2 。 凊 Refer to the circuit diagram of the transmission n of "Fig. 2". As shown, the transmitter no of the present invention includes a drive circuit m and a surge circuit 112. The drive circuit 111 has a waveform generator lm, a frequency division 1 § 1112 electrically connected to the waveform generator 1111, an inverter electrically connected to the frequency divider 1112, and a second power 1328444 connected to the inverter 1113. The modulators 1114 and 2 are electrically connected to the class D power amplifier 1115 of the modulator 1114 and the transformer 1116 electrically connected to the class D power amplifier 1115, respectively. The 8th wave riser v generator 11U is used to generate a square wave 'this square wave is transmitted through the frequency division · 'H 1112 light to the specific finer solution, and the catch is reversed (four) 1113 to transfer the square wave after the adjustment to the second The modulator 1114 is configured to generate two inverted square wave signals having a fixed wave width and amplitude, respectively. The square wave signal is transmitted to the transformer 1116 via the gain of the power amplifier, and is converted by the two transformers (1) 6, so that the positive wave signals are respectively outputted by a sine wave and a negative sine wave type control signal. The oscillating circuit 112 of the transmitter 110 includes a power source 112 and two electrical connections; an electric body opening 1122 of the electric source 1121; and a resonant circuit 1123 electrically connected to the transistor switch Π22, the resonant circuit rib-electric The first connection of the transistor 幵1, 1122, the induction coil 1124, and the electrical connection to the capacitor U25 of the second induction coil 1124. Difficulty, the 'diode switch 1122 is used to receive the change; the control signal of the 1116 1116 is reversed and the other transistor switch 1122 is turned on or off. The power mH tank is in the state of the transistor ΐ 22, and continuously turns on the motor to the resonance circuit (1) 3, and the second induction coil ι 24 generates and emits a wireless signal to the first induction coil by the charge and discharge of the capacitor. (2), forming a magnetic field inductive coupling. Please refer to the block diagram of the light illuminator in Figure 3A and Figure 3B. The control circuit 122 of the light illuminator 120 has a rectifier 1221 connected to the rectifier 1222 of the rectifying H 1221 and the illuminating element (2). The control circuit 12224 converts the magnetic wireless signal received by the first induction coil 121 into an electrical driving signal, and the driving signal acts through the rectifier 1221 to convert the originally driven driving signal into one direction. The signal of the shock is maintained by the regulator 1222 to maintain a certain range of output values to prevent the light-emitting element 123 from being damaged due to the unstable voltage* value of the driving signal. The rectifier 1221 disclosed in the present invention can be a rectifier of any type of half-wave rectifier, full-wave rectifier, or bridge rectifier. However, this technology has been known to those familiar with the art. Therefore, the inventor does not elaborate on φ. Please continue to refer to "Fig. 3A". The periphery of the light illuminator 12 has a transparent permeable cover material 150' to completely cover the first induction coil (2), the control circuit 122, and the illuminating element 123. The covering material 15 is made of bio-based silicone material or glass material, which not only has good biocompatibility, but also has excellent insulation and heat dissipation effect, and avoids the light illuminator disposed in the biological body. 12〇, the excessive heat generated by the operation caused the discomfort of the creature. _ From the light exposure H 12G has excellent (four) money mixed, 0 this can be selected after the end of the treatment, the light illuminator 120 is taken out from the body of the organism 200; or long-term placement

:於生物200體内,以免除再次進行外科手術的不便,以及必須承 擔的風險性。 X 如「第1B圖」所示’本發明更包含有一銜接於發光元件 之散射兀件130,放置於生物綱體内之散射元件13()具備有_ 好的生物相·,不剌起生物的免疫排歧應。本發明戈 散射元件130係為一内部具有容置空間之球體材料,且於散射月 件130崎填裝有—流體14(),例如為空氣、生理食鹽水、或巧 12 1328444 油水扣σ物等冋散射性之流體14G,其巾油水混合物可選用力保 ':肪'r (hP〇fimdm)或是因特立滋(intralipid),以做為光線散射之流體 140。 本發明之「第4圖~^系以油水混合物·力保肪寧(lipoflmdin) •做為本實施例之_,發光元件123發出之柯功率大小的光 '線,透過散射元件130内之流體M〇(以0.12%之li_ndin為例) =產生穿透並向外儲’其級之穿紐射率麵著光功率的提 鲁高而呈線性增加。操作者可根據實際治療需求而選用適當的光功 率大小’以均勻照射生物2〇〇體内的組織細胞,而達到高效率且 效果良好的光動力治療效果。 此外,「第4圖」同時比較將發光元件123置於散射元件13〇 内以及將發光元件123銜接於散射元件13〇表面之散射穿透率 的差異。由1測結果得知,發光元件123置於散射元件内之 穿透散射率,遠低於發光元件123銜接於散射元件13〇表面之散 _射率。因此,本發明係以發光元件123銜接於散射元件⑽表面 之型態作為最佳實施例之說明。 此外,為了確認設置於生物2〇〇體内之光照射器12〇確實地 作動,如「第3入圖」及「第3B圖」所示’本發明在進行治療時, 亦可於發光元件123内安裝有光感測器17〇 ’用以偵測發光元件 ⑵之透鏡所折射回來的光線,以推算發光元件⑵所發出之光 強度。光感測器170係電性連接於控制電路122,以偵測由發光 兀件123射出之光線強度,並將此光功率之類比訊號傳送至控制 電路22巾以進行訊號的數位解調,再以無線射頻⑽)或是微 13 1328444 ‘波等無線傳輪方式傳送至外部的解調器(圖中未示),從而得知目前 --的發光強度’以輔助醫療者換算病患所需照射的時間。 或是於接近光照射器12G之生物綱體外設置-光感測器(圖 中未不)’以接收光照射|| 12〇以無線訊肋饋其目前的作動狀 .態、,例如回饋其發光元件123是否發出紐、及此光線的光功率 ' 大小等情況,使醫療者得㈣解生物2GG翻的治療情況。 如第13圖」及「第5圖」所示,為了觀察内部的治療狀況, • 更可於生物200體内裝設一取像裝置酬。其中,取像裝置⑽ 具有-處理H 181 ’及電性連接於處理器181之第三感應線圈 182、取像器183、與無線訊號發射器184。第三感應線圈脱於 接收第二錢、_ 1124所發出之鱗纖制始伽,當光照射 器120照射生物200的過程中’取像器183將生物藉由光線 而產生之光強度’透過處理器⑻轉換為一輸出訊號,並經由無 線訊號發射器184,以無線射頻㈣或是微波等無線傳輸方式傳送 • 至外部的接收器(圖中未示)’從而得知目前的内部治療狀況。 :· 糾’為了快速處理取像裝置180所產生的輸出訊號,更可 •於光照射益120内加設二天線⑽中未示),以分別接收及傳輸輸 出訊號,使得以圖像訊號為主之輸出訊號,得以快速地傳遞至外 部的接收器。 取像裝置180亦可結合於光照射器120内,無需使用第三感 應線圈182 ’藉由共用控制電路122所產生之電流,以驅動取像 盗183作動’使得设置於生物2〇〇體内之裝置可更為精簡。 如「第3C圖」所示’本發明之光照射器,更包括有一二次 器-及穩控制電路:22之驅動訊號經由整流 透過外部無線觸發的气、以對— 人電池190進行充電,再 電能至發光元件動二電池190執行或是停止提供 中未示)鮮,使物=1112G無魏物部之發射器(圖 其中,啟誠γ μ 不鎌制,柯持續地進行治療。 _入/疋 次電池19G之電力輪出,可藉由不同頻率 _合峨、财__柄、歧_纽號技術ΐ 調外部訊麟驅動方式,以對二次電池190進行控制。 ;第6八圖」至「第犯圖」為本發明之感應裳置應用於治療 及7斷生物各雜之織的示意圖。本發明揭露之感應裝置 應可應用於治療人體2〇〇(生物體)各個部位,例如顧腔、口腔、 ,腔、腹腔、骨盆腔内之各器官組織_瘤治療。本發明之發射 器110可藉由-綁持或是縣於人體200上的保持件·而固定 設置於相對人體200 It内之光照射器12〇的位置,以使發射器11〇 得以與光歸H 120之間透過無線射鮮輸財式進行治療。 保持件160上具有-容設部⑹,以供發射器11〇固設於其 中。且保持件160可配合人體200欲治療的部位,而設計為帽子、 口罩、或是束帶等各種型態,以方便佩帶綁持於人體2〇〇對應於 光照射器120之位置。 與習知技術相較,位於生物體外的發射器係藉由無線訊號的 傳輸’而與設置於生物體狀光騎H相互電_應,光照射器 藉由磁電轉換效應,而可發出特定波長的光線,以激發匹配之光 15 以進行生物體的診斷或是治療。本發 置以有線傳輸方式的不便,並降低人 敏感藥劑產生光化學反應,以 月改善了習用光動力治療裝置 體遭受細菌感染的危險性。 本發明之發射益更藉由保持件的設置,使得患者於治療過程 中的行動將不受發㈣的限制,並可精確湖光照㈣120之光: In the body of the body 200, in order to avoid the inconvenience of re-surgery, and the risk that must be undertaken. X, as shown in "Fig. 1B", the present invention further includes a scattering element 130 that is coupled to the light-emitting element, and the scattering element 13 () placed in the biological body has a good biological phase, and does not pick up the living organism. The immune response should be. The geospatial element 130 of the present invention is a spherical material having an accommodating space therein, and is filled with a fluid 14 (), such as air, physiological saline, or clever 12 1328444 oil-water buckle σ. Equal to the scattering fluid 14G, the towel oil-water mixture can be used to protect ': fat'r (hP〇fimdm) or intralipid as the light scattering fluid 140. In the fourth aspect of the present invention, the oil-water mixture, lipoflmdin, is used as the embodiment, and the light-powered light emitted by the light-emitting element 123 passes through the fluid in the scattering element 130. M〇 (for example, 0.12% of li_ndin) = Produce penetration and store outwards. The penetration rate of the grade is linearly increased by the height of the light. The operator can choose according to the actual treatment needs. The light power level 'is uniformly irradiated the tissue cells in the living body 2 to achieve a highly efficient and effective photodynamic therapeutic effect. Further, "Fig. 4" simultaneously compares the light-emitting element 123 to the scattering element 13 The difference in the scattering transmittance between the inside and the surface of the scattering element 13 is connected to the light-emitting element 123. It is known from the results of the measurement that the transmittance of the light-emitting element 123 placed in the scattering element is much lower than the scatter rate at which the light-emitting element 123 is coupled to the surface of the scattering element 13. Accordingly, the present invention is described in terms of a preferred embodiment in which the light-emitting element 123 is coupled to the surface of the scattering element (10). In addition, in order to confirm that the light illuminator 12 设置 provided in the body of the living body is activated, as shown in "3rd drawing" and "Fig. 3B", the present invention can also be used for a light-emitting element when performing treatment. A light sensor 17 is mounted in the 123 to detect the light refracted by the lens of the light-emitting element (2) to estimate the light intensity emitted by the light-emitting element (2). The light sensor 170 is electrically connected to the control circuit 122 to detect the intensity of the light emitted by the light-emitting element 123, and transmits the analog signal of the optical power to the control circuit 22 for digital demodulation of the signal. Transmitted to an external demodulator (not shown) by radio frequency (10) or micro 13 1328444 'waves, etc., to know the current luminous intensity' to assist the medical practitioner in converting the patient's needs The time of the exposure. Or in the external setting of the biological device close to the light illuminator 12G - the light sensor (not shown in the figure) to receive the light irradiation || 12 〇 to wirelessly feed the ribs to its current state of operation, for example, to feed back Whether or not the light-emitting element 123 emits a light, and the optical power of the light, such as the size, allows the medical practitioner to obtain (4) the treatment of the biological 2GG. As shown in Figure 13 and Figure 5, in order to observe the internal treatment status, an imaging device can be installed in the body of the living body 200. The image capturing device (10) has a processing H 181 ', a third inductive coil 182 electrically connected to the processor 181, an image finder 183, and a wireless signal transmitter 184. The third induction coil is detached from the scaly singer sent by the second money _ 1124. When the light illuminator 120 illuminates the living body 200, the image finder 183 transmits the light intensity generated by the light by the light. The processor (8) converts into an output signal and transmits it via a wireless signal transmitter 184 to a wireless receiver (four) or a microwave or the like to an external receiver (not shown) to learn the current internal treatment status. . :· In order to quickly process the output signal generated by the image capturing device 180, it is also possible to add two antennas (10) (not shown) in the light exposure 120 to respectively receive and transmit the output signals so that the image signals are The main output signal is quickly transmitted to the external receiver. The image capturing device 180 can also be incorporated into the light illuminator 120 without using the current generated by the common control circuit 122 by using the third induction coil 182 ′ to drive the image thief 183 to operate. The device can be more streamlined. As shown in the "3C", the light illuminator of the present invention further includes a secondary device and a stable control circuit: the driving signal of the 22 is recharged through the external wirelessly triggered gas to charge the battery 190. Then, the electric energy is sent to the light-emitting element to operate the second battery 190 to execute or stop the supply of the transmitter (not shown), and the object is 1112G without the transmitter of the Weiwu part (in the figure, Qicheng γ μ is not smashed, and Ke continues to perform treatment. The power supply of the 19G battery can be controlled by the different frequency _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ 6图图至《第一犯图" is a schematic diagram of the sensing skirt of the present invention applied to the treatment and the woven fabric of the 7-breaking organism. The sensing device disclosed in the present invention should be applicable to the treatment of human body 2 (organism) Various parts, such as the cavity, the oral cavity, the cavity, the abdominal cavity, and the various organs in the pelvic cavity are treated. The emitter 110 of the present invention can be fixed by the -binding or the holder on the human body 200. Positioned in the light illuminator 12〇 relative to the human body 200 It so that The transmitter 11 is capable of being treated by the wireless fresh-earning type between the light source and the H 120. The holder 160 has a receiving portion (6) for the emitter 11 to be fixed therein, and the holder 160 can be matched. The body 200 is intended to be treated, and is designed in various forms such as a hat, a mask, or a belt to facilitate wearing the position of the human body 2 corresponding to the light irradiator 120. Compared with the conventional technology, it is located The extracorporeal emitter is electrically connected to the living body by means of the transmission of the wireless signal. The light illuminator emits light of a specific wavelength by the magnetoelectric conversion effect to excite the matched light. 15 For the diagnosis or treatment of living organisms, the present invention has the inconvenience of wired transmission, and reduces the photochemical reaction of human sensitive agents, thereby improving the risk of bacterial infection of the conventional photodynamic therapy device body by month. The launching benefit is made by the setting of the holder, so that the patient's action during the treatment will not be restricted by the hair (4), and the precise lake light (four) 120 light

時獲得較佳治療效果之功效。 雖然本發明之實施例揭露如上所述,然並非用以限定本發 月任何一習相關技藝者,在不脫離本發明之精神和範圍内,舉 凡依本發财4範圍所述之形狀、構造、特徵及精神當可做些許 之隻更’因此本發明之專利傾範關視本綱書賴之申請專 利範圍所界定者為準。 【圖式簡單說明】 苐1A圖為本發明感應裝置之平面示意圖; 第1B圖為本發明之感應裝置應用於人體上之侧視圖; 第2圖為本發明發射器之電路方塊圖; 第3A圖為本發明光照射器之立體示意圖; 第3B圖為本發明光照射器之電路方塊圖; 第3C圖為本發明具有二次電池之光照射器之電路方塊圖; 第4圖為本發明之不同光功率之光線經由散射元件之流體所產生 之穿透散射率之量測圖; 第5圖為本發明取像裝置之電路方塊圖; 第6A圖為本發明之感應裝置應用於人體顱腔組織之診斷及治療 1328444 之側視圖; 第6B圖為本發明之感應裝置應用於人體口腔組織之診斷及治療 之側視圖; 第6C圖為本發明之感應裝置應用於人體胸腔器官之診斷及治療 之側視圖; 第6D圖為本發明之感應裝置應用於人體腹腔器官之診斷及治療 之側視圖;以及 第6E圖為本發明之感應裝置應用於人體骨盆腔器官之診斷及治 療之側視圖。 【主要元件符號說明】 100 感應裝置 110 發射器 111 驅動電路 1111 波形產生器 1112 除頻器 1113 反向器 1114 調變器 1115 功率放大器 1116 變壓器 112 震盪電路 1121 電源 1122 電晶體開關 1123 共振電路 17 第二感應線圈 電容 光照射器 第一感應線圈 控制電路 整流器 穩壓器 發光元件 散射元件 流體 包覆材料 保持件 容設部 光感測器 取像裝置 處理器 第三感應線圈 取像器 無線訊號發射器 二次電池 充放電迴路 生物 18The effect of obtaining a better therapeutic effect. Although the embodiments of the present invention are disclosed above, it is not intended to limit the scope and scope of the present invention, and the shapes and structures described in the scope of the present invention 4 are not deviated from the spirit and scope of the present invention. , the characteristics and the spirit can be done a little more than 'therefore, the patent of the invention is subject to the definition of the patent application scope of this application. BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1A is a plan view of a sensing device according to the present invention; FIG. 1B is a side view of the sensing device of the present invention applied to a human body; FIG. 2 is a circuit block diagram of the transmitter of the present invention; Figure 3B is a block diagram of a light illuminator of the present invention; Figure 3C is a block diagram of a light illuminator having a secondary battery of the present invention; The measurement of the penetration scattering rate of the light of different optical powers through the fluid of the scattering element; FIG. 5 is a circuit block diagram of the image capturing device of the present invention; FIG. 6A is a schematic view of the sensing device of the present invention applied to the human cranial cavity Side view of the diagnosis and treatment of the tissue 1328444; Figure 6B is a side view of the diagnosis and treatment of the sensing device of the present invention applied to the human oral tissue; Figure 6C is a diagnosis and treatment of the inductive device of the present invention applied to the human thoracic organ 6D is a side view showing the application of the sensing device of the present invention to the diagnosis and treatment of a human abdominal cavity organ; and FIG. 6E is a view showing the application of the sensing device of the present invention to a human Side view of the diagnosis and treatment of the pelvic organs of the body. [Main component symbol description] 100 Induction device 110 Transmitter 111 Driving circuit 1111 Waveform generator 1112 Frequency divider 1113 Inverter 1114 Modulator 1115 Power amplifier 1116 Transformer 112 Oscillation circuit 1121 Power supply 1122 Transistor switch 1123 Resonance circuit 17 Two Induction Coil Capacitor Light Irradiator First Induction Coil Control Circuit Rectifier Regulator Light-emitting Element Scattering Element Fluid Cladding Material Holder Capacitor Photosensor Image Pickup Device Processor Third Induction Coil Imager Wireless Signal Transmitter Secondary battery charge and discharge circuit biology 18

Claims (1)

1328444 十、申請專利範圍·· 了種應用於杨力轉與治療之感縣置,係使祕一生物 ^吨發該生物體内之級感_產生絲學反應,該感 應裝置包括有: X射器用以發出—穿透該生物表層之無線訊號;以及 一光照射器’係設置於該生物體内,其具有:1328444 X. The scope of application for patents·············································································· The emitter is configured to emit a wireless signal that penetrates the surface of the biological body; and a light illuminator is disposed in the living body, and has: 一第一感應線圈’用以接收該無線訊號; 控制電路電性連接於該第一感應線圈,並將該無 線訊號轉換為一驅動訊號;以及 一發光耕,紐連胁雜缝路,紐光元件由 Γ動訊觸,⑽编_產生光化 圍第1項所述之翻於光動力診斷與治療之感應 射器包含有一驅動電路及-震盪電路,該驅動 湖喊’該震盪電路係紐連接於該驅動 電路’以將該控制訊號轉換為該無線訊號並發出。 =:_第2項所述之應用於光動力診斷與治療之感應 裝置,其中該驅動電路更包含有一波形產生器、一電性連接於 該波形產生器之除頻器、-電性連接於該除頻器之反向哭、至 rtf接於該反向器之調變器、至少—電性連接於_變 :之功率放大器、以及至少-電性連接於該功率放大器 益’以產生該控制訊號。 4.如申請翻第2項所述之躺於光動力診斷與治療之感應 裴置,f = 電,,、中該震盪電路更包含有一電源、至少一電性連接於該 路源之電晶體開關、及一電性連接於該電晶體開關之共振電 該電日曰體開關接收該控制訊號,以控制該共振電路發出該 JL該第—感應線圈。 =申请專利範圍第4項所述之顧於光動力診斷與治療之感應 、置,其中該共振電路具有一第二感應線圈及一電容,該第二 感應線圈·連接於該電晶體開關,該電容係電性連接於該第 p感應線圈,且該第二線圈藉由該電容之充放電作用,以發出 該無線訊號至該第一感應線圈。 如申請專利麵第1項所述之應驗絲力診斷無療之感應 =置’其巾更包含有_銜接㈣發光元件之散射元件,且該散 、元件内具有—容置空間,並填裝有—流體,以使該光線產生 散射。 ’:申請專利範圍第6項所述之應驗光動力診斷與治療之感應 、置’其中該流體係選自於由空氣、生理食鹽水、及油水混合 物所構成之群組。 .如申請專利範圍第7項所述之應用於光動力診斷與治療之感應 農置’其中該油水混合物係為力保肪寧(lipofimdin)或是因特立 滋(intralipid)。 如申清專利範圍第1項所述之應用於光動力診斷與治療之感應 裝置,其中該控制電路具有—整流器及—穩顧,該整流器用 以接收該轉訊號’該穩麵電性連接該整流狀該發光元 件’以對該驅動訊號整流及穩壓。 20 項所述之應概動力診斷與治療之感應 性之包覆= 覆於該光關11相並具有生物相容 復材科,以使該光照射器絕緣及散熱。 應^置月專第霜^項所述之應用於光動力診斷與治療之感 /、中該匕覆材料係為矽膠材料或是破璃材料。 裝置申利範圍第】項所述之應用於光動力診斷與治療之感應 、㈣發光元件係為發光二極體或是雷射二極體。 13·如申請專利範圍第!項所述之應用於光動力診斷與治療之感應 1、中更包含有-保持件,且該保持件具有一容設部,以 固定該發射器於該保持件上。 申月專她圍第1項所述之應用於光動力診斷與治療之感應 、置’其中更包含有-域· ’係電性連接於該控制電路, X於該發光元件發出該光線時,偵測該光線之強度,並傳送 至該控制電路。 如申明專她圍第1項所述之應用於光動力診斷與治療之感應 裝置,其中更包含有一取像裝置,其具有: 一處理器; 一第二感應_,電性連接於該處理器,肋接收該無線 訊號’並驅動該處理器; -轉S ’電性連胁該驗器,以侧該生物藉由該 光線所產生之光強度’並藉由該處理器轉換為__輸出訊號;以 及 ,用以發射該輸 一無線訊號發射器,電性連接於該處理器 21 S 1328444 出訊號。 .· 16.如中請專利範圍第丨項所述之應用於光動力診斷與治療之感應 . 裝置其巾該光&、射器更包括有-二:欠電池,係電性連接該控 制電路及該發光元件,以提供一電能至該發光元件。 • Π.如帽專利細第16項所述之顧於光動力診斷與練之感 -應裝置’其+該—:欠電池更具有_充放電迴路,該充放電迴路 藉由該控制電路之驅動訊號,以對該二次電池進行充電。 φ 18.一種應用於光動力診斷與治療之光照射器,係設置於一生物體 内,該光照射器藉由一穿透該生物表層之無線訊號而發出一光 線,以激發該生物體内之光敏感藥劑產生光化學反應,該光照 射器包括有: 一第一感應線圈,用以接收該無線訊號; 一控制電路,電性連接於該第一感應線圈,並將該無線訊 號轉換為一驅動訊號;以及 ^ 一發光元件,電性連接於該控制電路,該發光元件由該驅 - 動訊號驅動而發出光線,以使該光敏感藥劑產生光化學反應。 » . 19.如申請專利範圍第18項所述之應用於光動力診斷與治療之光 照射器’其中更包含有一銜接於該發光元件之散射元件,且該 散射元件内填裴有一流體,以使該光線產生散射。 20. 如申請專利範圍第19項所述之應用於光動力診斷與治療之光 照射器,其中該流體係選自由空氣、生理食鹽水、及油水混合 物所構成之群組。 21. 如申請專利範圍第20項所述之應用於光動力診斷與治療之光 22 u/6444 :裔,其中該油水混合物係為力保肪寧(Hpofixnfe)或是因特 立滋(intralipid)。 22. ^料概8第18項之應胁絲力輯與治療之光 ’其中該控制電路具有—整流器及—穩壓器,該整流器 j性連接該第一感應線圈,該穩壓器電性連接該整流器及該 發光元件’以對該驅動訊號整流及穩壓。 23. ,申請專利範圍第18項所述之朗於光動力診斷與治療之光 照射器,其中更包括有一包覆於該發光器外圍並具有生物相容 性之包覆材料,以使該發光器絕緣及散熱。 如申請專利細第23項所述之綱於_力診峨治療之光 照射器’其中該包覆材料係為矽膠材料或是坡填材料。 25.如申料利棚第I8 _述之應轉先動力診峨治療之光 照射器,其中該發光元件係為發光二極體或是雷射二極體。 23a first inductive coil 'for receiving the wireless signal; a control circuit electrically connected to the first inductive coil, and converting the wireless signal into a driving signal; and a luminous ploughing, a new connection, a splicing road, a neon light The component is triggered by the stimuli, (10) _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ Connected to the driving circuit 'to convert the control signal into the wireless signal and send out. =: The sensing device for photodynamic diagnosis and treatment according to Item 2, wherein the driving circuit further comprises a waveform generator, a frequency divider electrically connected to the waveform generator, and is electrically connected a reverse crying of the frequency divider, a modulator connected to the rtf to the inverter, a power amplifier at least electrically connected to the converter, and at least electrically coupled to the power amplifier to generate the Control signal. 4. If the application is placed in the inductive device for photodynamic diagnosis and treatment as described in item 2, f = electricity, wherein the oscillating circuit further comprises a power source, at least one transistor electrically connected to the source. And a switch electrically connected to the resonant switch of the transistor switch to receive the control signal to control the resonant circuit to emit the JL the first induction coil. The invention relates to the sensing and setting of the photodynamic diagnosis and treatment described in claim 4, wherein the resonant circuit has a second induction coil and a capacitor, and the second induction coil is connected to the transistor switch, The capacitor is electrically connected to the p-th induction coil, and the second coil is charged and discharged by the capacitor to emit the wireless signal to the first induction coil. As claimed in the first paragraph of the patent application, the diagnosis of the wire force diagnosis is untreated. The toothbrush further includes a scattering element of the (four) light-emitting element, and the space has a space for accommodation and is filled. There is a fluid to scatter the light. ': Inductive photodynamic diagnosis and treatment according to item 6 of the patent application scope, wherein the flow system is selected from the group consisting of air, physiological saline, and oil-water mixture. The invention is applied to photodynamic diagnosis and treatment as described in claim 7 of the invention, wherein the oil-water mixture is lipofimdin or intralipid. The sensing device for photodynamic diagnosis and treatment according to claim 1, wherein the control circuit has a rectifier and a steady state, and the rectifier is configured to receive the signal signal. The light-emitting element is rectified to rectify and stabilize the driving signal. The inductive coating of the dynamic diagnosis and treatment described in the 20th item = covering the phase 11 of the light and having a biocompatible composite material to insulate and dissipate the light illuminator. It should be used for the diagnosis and treatment of photodynamics as described in the section of the Moon. The material used in the design is a silicone material or a glass material. The device is applied to the measurement of photodynamic diagnosis and treatment as described in item 】, and (4) the light-emitting element is a light-emitting diode or a laser diode. 13·If you apply for a patent scope! The invention relates to the application of the photodynamic diagnosis and treatment, and further includes a holder, and the holder has a receiving portion for fixing the emitter on the holder. Shen Yue specializes in the sensor for photodynamic diagnosis and treatment described in Item 1, which further includes a - domain · ' is electrically connected to the control circuit, X when the light emitting element emits the light, The intensity of the light is detected and transmitted to the control circuit. The invention relates to a sensing device for use in photodynamic diagnosis and treatment according to Item 1, which further comprises an image capturing device, comprising: a processor; a second sensing_ electrically connected to the processor The rib receives the wireless signal 'and drives the processor; - turns S 'electrically threatens the detector to side the light intensity generated by the light by the light' and is converted to __ output by the processor And a signal for transmitting the wireless signal transmitter, and is electrically connected to the processor 21 S 1328444. 16. The application of the application of photodynamic diagnosis and treatment as described in the scope of the patent scope is as follows. The device includes the light & the emitter further includes a -2: under-battery, electrically connected to the control a circuit and the light emitting element to provide an electrical energy to the light emitting element. • Π. As described in Article 16 of the patent patent, the sense of photodynamic diagnosis and practice - the device should be 'the +----the battery has a _ charge and discharge circuit, and the charge and discharge circuit is controlled by the control circuit. Driving a signal to charge the secondary battery. Φ 18. A light illuminator for use in photodynamic diagnosis and treatment, disposed in a living body, the light illuminator emitting a light by a wireless signal penetrating the surface of the biological body to excite the living body The light-sensitive agent generates a photochemical reaction, the light illuminator includes: a first induction coil for receiving the wireless signal; a control circuit electrically connected to the first induction coil, and converting the wireless signal into a a driving signal; and a light-emitting element electrically connected to the control circuit, the light-emitting element being driven by the driving signal to emit light to cause a photochemical reaction of the light-sensitive agent. 19. The light illuminator for photodynamic diagnosis and treatment according to claim 18, further comprising a scattering element coupled to the illuminating element, wherein the scattering element is filled with a fluid to The light is scattered. 20. The light illuminator for photodynamic diagnosis and treatment according to claim 19, wherein the flow system is selected from the group consisting of air, physiological saline, and oil-water mixture. 21. The light applied to photodynamic diagnosis and treatment as described in claim 20, wherein the oil-water mixture is Hpofixnfe or intralipid. . 22. The material of the 8th item of the 18th item is the light of the treatment and the light of the treatment. The control circuit has a rectifier and a voltage regulator. The rectifier is connected to the first induction coil. The voltage regulator is electrically connected. The rectifier and the light emitting element are connected to rectify and stabilize the driving signal. 23. The light illuminator for photodynamic diagnosis and treatment according to claim 18, further comprising a covering material coated on the periphery of the illuminator and having biocompatibility to enable the illuminating Insulation and heat dissipation. For example, the light illuminator of the invention described in claim 23, wherein the covering material is a silicone material or a slope filling material. 25. For example, the light illuminator that should be transferred to the first power diagnosis and treatment, wherein the light-emitting element is a light-emitting diode or a laser diode. twenty three
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