TWI313160B - Poultry feed and the use thereof - Google Patents

Description

1313160 IX. Description of the Invention: [Technical Field to Which the Invention Is Affected] Field of the Invention The present invention relates to a cysteine-containing composition for use as a feedstock for poultry. On the date of this issue, there is a kind of feed (material) containing the composition to raise poultry and the preparation of the feed.

t Λ. ]J Background of the invention

10 15

Cysteamine has been used in feed supplements for the growth of meat-producing animals. U.S. Patent No. 4,711,897 discloses an animal feeding method and a feed composition comprising hemiamine. "It has been determined that (iv) cysteamine is a fairly sensitive and unstable compound at room temperature. For example, cysteamine is rapidly oxidized when exposed to air or at increasing temperatures. Cysteamine is very easy Similarly, cysteamine is unpalatable when taken directly from the mouth. Further, direct absorption of cysteamine will cause unwanted side effects of the stomach. Therefore, the use of cysteamine has been limited for some time. The cysteamine-containing solution is directly injected into the meat-producing animal. The disadvantage of direct injection is that it must be expensive and difficult to manage on a large farm. The Chinese mainland application No. 00132107.2 discloses the improvement of the cysteamine-containing composition 20, It can be blended with standard animal feed to promote growth and increase animal weight. However, there is still a need for compositions and/or methods for increasing the yield and quality of eggs such as hens. The method can be easily managed and inexpensively implemented. The produced egg can be used as a food. Optionally, the egg can be used as an egg. 1313160 One week of laying eggs by poultry laying hens The pattern of the period is known, which means that when the laying hens are getting older, the yield of the eggs is reduced. Studies have pointed out that this phenomenon is mainly caused by the decline in the reproductive capacity of the laying hens. 5 [Summary of the Invention] Summary of the Invention According to a first aspect of the present invention, there is provided a use of a cysteamine-containing composition for the manufacture of poultry feed (material) to increase the amount and/or quality of egg production. In particular, the poultry is a hen.

Preferably, the composition may substantially comprise cysteamine or a salt thereof having from 1 to 95% by weight of the chemical formula of NHrCHrCHrSH. The composition may comprise from 1 to 80% by weight of a stabilizer. More particularly, the stabilizer may be selected from the group consisting of cyclodextrin or a derivative thereof. For example, the composition may comprise 10% by weight of a stabilizer. Suitably, the composition may further comprise a component selected from the group consisting of a leavening agent, a fragmentation agent, and a coated support. The support can be a solid support. The carrier can be coated and soluble in the intestines of the poultry. The support can exhibit a multi-layered structure in the composition. The residue is insoluble at pH 1. 5 to 3.5. In any event, the support can be adapted to be insoluble in an environment such as a higher pH in the intestinal tract. Advantageously, the feed may comprise other foodstuffs selected from the group consisting of corn, soybean, yeast, fishbone flour, salts, methionine, amino acids, vitamins. More particularly, the composition may comprise substantially 30% by weight of cyste 1313160 amine. The rhyme may comprise cysteamine which may comprise substantially 15 to __. In particular, the feed may comprise substantially 12% hemiamine. According to a second aspect of the present invention, there is provided a method for raising poultry, the method comprising: (m containing a cysteamine composition (as described above) mixed with a feed (material) suitable for domestic and poultry, and (ii) Feeding the poultry with the feed. 'The ground' is in step (1), the (four) is directly mixed with the feed. Optionally, the mixture means first preparing a premix comprising the cysteamine-containing composition. And then mixing the premix with the feed. According to a second aspect of the present invention, there is provided a feed (material) for poultry comprising a composition comprising 10 cysteamine. Containing a cysteamine or a salt thereof having a % to 95% by weight of the 2-CH2_CH2-SH formula. More particularly, the composition may further comprise from 丨 to 8% by weight of a stabilizer. It is selected from the group consisting of a cyclic dextrin or a derivative thereof. The composition may comprise 10% by weight of a stabilizer. • Suitably, the composition may further comprise a component, the component Selected from. One includes a leavening agent, a breaker, and a coated carrier. The group formed by the body can be a single solid carrier. The carrier can be coated and soluble in the intestine of the poultry. - The carrier can exhibit a multi-layer structure in the composition. The feed may further comprise other foodstuffs selected from the group consisting of corn, soybean, yeast, fish bone shell powder, salt, methionine, and the like. A group consisting of amino acids and vitamins. Suitably, the composition may comprise substantially 3% by weight of cysteamine. 1313160 The feed for poultry may comprise substantially 50 to 300 ppm of the composition. The feed may comprise substantially 150 to 900 ppm of cysteamine. More particularly, the feed may comprise 120 ppm of cysteamine. According to a fourth aspect of the invention, a feed (material) is provided, the feed 5 comprising a cysteamine The steps of mixing the feed with a suitable base feed. Brief Description of the Invention The invention is described by way of non-limiting example, with reference to the accompanying drawings, wherein: Figure 1 shows the two groups of laying hens in an experiment. Egg production rate chart; Figure 2 shows two experiments in the experiment The abnormal egg ratio of laying hens is plotted as ίο and broken egg ratio; Figure 3 is a graph showing the feed conversion efficiency of the two groups of laying hens during the experiment; and Figure 4 shows the two groups during the experiment. Egg hen rate map of the egg hen. [Embodiment 3] The present invention is based on an illustration of the activity of the cysteamine-containing composition in the production and quality of egg production when it is absorbed by egg-producing poultry such as chicken. There is no suggestion or suggestion that cysteamine or a variant or derivative thereof may have 20 such activities. The present invention provides a method of raising egg-laying poultry, particularly for laying hens, by feeding a cysteamine-containing composition The feed (material) of the product is used to increase the yield and quality of the egg production. The use of the present invention also prolongs and improves the egg production performance of the late poultry. The present invention can be carried out by directly mixing the cysteamine-containing composition with a standard basal feed of a suitable type. Optionally, the present invention can be selected from a first premix of a cysteamine-containing composition and other components by mixing a first 1313160, and secondarily mixing the premix with other standard feeds. The effect of the cysteamine-containing composition is as described in the Chinese Patent No. 00132107. 2: Application, the contents of which are incorporated herein by reference. It is generally believed that cysteamine has a physiological activity that acts as a growth promoter. The natural cysteamine is a part of coenzyme A (known as CoA-SH or CoA), and 'Kesaki A' is a coenzyme form of pantothenic acid. In the metabolic pathway, coenzyme a is used as a dihydrothio group or a dihydrothio-based variant of a dihydrothio group attached to a sulfonium A, such as scorpion, goat, rabbit, fish, and other animals. A one-way experiment showed that cysteamine reduced the level of growth hormone inhibitory factor (ss). The increase in the growth hormone levels of these animals sequentially increases the levels of various other growth stimulating factors, including the gonadotropin-inducing factor I(10)-I), temsin, triterpene thyroxine (10), thyroxine (10). And beta-catenin (beta__. Growth hormone is thought to directly stimulate the new generation of steroids and gamete production and typographical nesting activities. Birds) (4) Nests, especially the crust glands, are the sites of action. The height of the body is expressed in the nest of the chicken. Now the increase of these two growth-promoting factors, the animal's digestive metabolic rate corresponds to: t曰 plus. It can be understood that the feed conversion efficiency is improved. Further, the animal is further improved. The rate of protein synthesis is thus increased. It is believed that it can be reduced by one, and the cell membrane is 4 cycles. On the other hand, the activity of fat synthesis and transmission is reduced. ^_The effect also enhances the spirit of poultry, and therefore egg production (and Increased egg production rate. Various embodiments have been shown to provide - a diet with a cysteamine composition of 1313160 - by which the chicken can increase the yield of laying eggs The embodiment is described in detail below. Example of the scene information This embodiment was implemented in an industrial chicken breeding farm located in Shanghai, China, on 2nd and 3rd of March. Use _ for 3Q5 days old The chickens of the sea M_ailar〇' experiment were housed in cages of standard half-style chicken houses with automatic feeding and drinking systems. The chickens in the experiment included a total of 2042 laying hens, of which 12 (10) were used for control purposes only, and the rest were used. For the purpose of the experiment (experimental), the basic diet including corn and soybeans is past-to-feed chicken. The details of the basic diet are further summarized below. 15 Materials The two groups of feed materials are prepared, and the test group contains the cysteamine-containing composition. The basal diet without the composition is contained. The cysteamine-containing composition in the micropill form comprises 30% by weight of cysteamine together with other components including a cyclodextrin as a stabilizer. The content of the cyclodextrin was 10% by weight in the composition. The composition was prepared by Walc〇m Biochemical Industry Co., Ltd. & Regarding the test group, the composition was first combined with various premix groups. Parts such as amino acid bismuth, calcium and crude protein are mixed to form a premix. The premixer is mixed with a suitable base feed material. The formulation of the feed material is summarized in Table 1. In the final feed material The concentration of the composition is substantially 1313160 4 〇〇 ppm. In other words, the effective concentration of cysteamine in the feed material is 120 ppm. The cysteamine composition may contain 1 to 95 gram of cysteamine. However, • 1 In the end, the final feed material of the test group was adjusted to the maximum of the composition - large 3 50 to 祁卯卯 " 1. Optionally, the test group material may actually contain 15.51 _ppm financial effect content. The composition in the experiment contains a cyclic group of -1G as described above. However, the composition may contain J to 80% by weight of the cyclodextrin depending on the actual amount of cysteamine used in the preparation of the contact. • u and other components including leavening agents, breakers and coated supports. The composition is in the form of a micropill having a multilayer structure. Thus, the composition is relatively stable in Form I and is insoluble in the pH of 1.5 to 3.5 (e.g., in the environment of the stomach) after absorption through the animal. However, the support made of the coating material is soluble in a high pH environment such as the intestinal tract. When the control group of the feed material is prepared, the premix is used without the cysteamine-containing composition. 15 • Steps. At the beginning of the day, 2G42 mothers depended on the experiment. These chickens were arbitrarily divided into a control group of 1200 'hens and a test (experimental) group of 842 chickens. All 2042, I hens were initially raised in the same environment except that the control group was administered a control group feed material containing no semi-20 amine composition, and the test group was administered to the experimental group containing the cysteamine-containing composition. Feed material. In the first four days and the next ^ days, δ has recorded the yield and quality of laying eggs. The amount of feed was also recorded. The egg production rate is calculated by the following formula. 11 1313160 Number of laying hens Number of laying hens (hens) Xl(K)% In addition, data from the two groups of hens used to calculate egg rate, egg fertilization and (iv) rate, breeder rate and feed conversion The number of eggs that are also recorded (desolvable) for efficiency is calculated according to the following formula. Total number of eggs = total number of eggs produced - all abnormal and broken eggs The rate of eggs produced by these hens as a percentage of the total number of eggs laid, which can be expressed by the following formula. Egg rate = some abnormalities and broken children's orders Ί 10 Egg fertilization rate The number of fertilized eggs produced by these hens as a percentage of the total number of eggs, which can be expressed by the following formula. Reading rate = 0 for -15 The hatching rate of eggs is the percentage of eggs that are finally hatched. The breeder rate is the percentage of healthy chickens that are suitable for further commercial farming. After the first four days, the test group continued to feed with the test group's feed material with 3 cysteamine, and the same control group still fed the control material for 2 days. The yield and quality of the eggs, as well as the feed used, were monitored and recorded in the same way. The data for the two groups of hens to calculate the egg rate of the egg, 'fertilization and purification rate, breeder rate and feed conversion efficiency, are also recorded. The feed conversion efficiency is calculated using the following formula 12 20 1313160. Feed conversion efficiency Total weight of feed material consumed per day Total weight of eggs produced per day At 325 days of age, 30 hens were randomly selected from the two groups. During this 5-day period, their excreta was collected and analyzed for their moisture content, organic matter, crude protein, crude ash, calcium, and phosphorus. The organic substance includes the crude protein. The coarse ash includes all such inorganic substances as calcium and phosphorus. The experiment lasted for a total of 29 days, including the initial 4 days of the preliminary experimental period. 10 Results The raw data collected was used to generate Table 2, which shows the egg production rate, abnormal egg rate, egg breaking rate and feed conversion efficiency of the two groups of hens. Figure 1 illustrates the egg production rate graphically. Figure 2 graphically illustrates the abnormal egg rate and egg breaking rate. As shown in Table 2 and Figure 1, the egg production rate of the test group was generally 3.86% higher than the control group during the experimental period φ 15 of 25 days. Referring to Table 2 and Figure 2, in general, the hens of the test group had substantially fewer abnormal eggs and broken eggs during the experiment. The number of eggs increased by 5.64%. In Table 2, the feed conversion efficiency data was used, and the test group was calculated to have a higher feed conversion efficiency of 9.71%. This means that the hens of the test group are fed with the test group feed material to convert the feed into eggs more efficiently. The third chart is a variation of feed conversion efficiency during the experiment. In general, the lower feed conversion ratio of the test group also indicates that the group can convert the feed to egg production more efficiently. 13 1313160 Figure 4 shows the variation in egg rate for two groups of hens during the experiment. In general, the curve exhibited by the test group hens was higher than that of the control group. This means that the chickens of the test group produce a higher percentage of good quality eggs. In Fig. 4, it should be noted that the experimental group curve generally changed to 5 〇 in the entire experiment, and the control group curve dropped to the end of the experiment. This suggests that egg production declines with the age of the hens in the control group. In other words, test group hens fed a feed with a cysteamine-containing composition maintained relatively high egg production. Table 3 summarizes the contents of the excreta produced by the two groups of chickens. There was no significant difference in the content of organic matter and crude protein in the cistern produced by the two groups of chickens. However, the amount of calcium and dish in the excrement produced by the chickens of the test group was substantially lower than that produced by the chickens of the control group. This display = hens in the test population can retain and absorb a higher percentage of food and phosphorus. It is believed that more efficient conversion of calcium and phosphorus to the eggshell provides the better egg quality (e.g., fewer broken eggs and abnormal eggs) produced thereby. 15 纟4 silk eggs produced by the test group and (4) group have similar fertilization rate, hatching rate and breeder rate. This confirms that the use of a feed material mixed with a cysteamine-containing composition can increase the laying rate of the hen and the rate of laying eggs. This also means that the eggs produced by the hens fed with the mixture containing the cysteamine composition have fewer abnormal eggs and 20 broken eggs. In other words, the quality of the eggs is improved. Further advancement is affected by the fertilization, hatching of the eggs and the intake of cysteamine by the lion. It is contemplated that the invention is applicable to other egg laying poultry. It should be noted that the cysteamine used is preferably stabilized by a stabilizer such as a cyclodextrin to prevent oxidation prior to absorption. If hemiamine is directly mixed with the 14 1313160 basal feed, cysteamine tends to oxidize immediately before being absorbed into the blood vessels of the chicken. Although the test group contained as much as 120 ppm of cysteamine as feed material, experiments have shown that the amount of cysteamine varies between 15 ppm and 900 ppm for chickens. For different sizes of laying poultry, the amount of effective cysteamine is generally provided according to the weight of the home 5 poultry type. For example, when used to increase the egg yield of a heavier weight duck, the feed used requires a higher stabilized cysteamine content. Each of the above-discussed documents, including the documents cited herein, is hereby incorporated by reference in its entirety. It is to be noted that a number of variations, modifications, and further embodiments of the invention are possible, and thus all such variations, modifications, and specific embodiments are considered to be within the scope of the invention. Table component composition, total weight % Nutritional composition corn 66. 6 11. 23 MJ, metabolizable energy (ME) Soy flour 16. 3 16.76 wt% crude protein (CP) Yeast 3. 7 0. 39 % by weight 曱 thiomethic acid (MET) fish meal 2.0 0.69 wt% methionine (MET) and cystine acid (CYS) bone powder 3. 0 0. 79 wt%, amide acid shell powder 7.5 3. 71 weight %, calcium premix 1.0 0. 55 wt%, total phosphorus salt 0. 30 0. 45 wt%, can be used to fill methionine 0. 18 —— total 100 -- 15 15 1313160

Age group egg production rate (%) Egg rate (%) Abnormal egg rate (%) Egg breaking rate (》 Feed conversion efficiency preliminary experiment control 1 to 4 4 82. 28±5.14 79. 08±4. 81 2. 39±1.10 1.47+0.05 2. 70±0. 26 Preparatory experimental test 1 to 4 4 80. 20±0. 93 78. 69±0. 75 1.44+0. 24 0.45±0.12 2. 54±0. 03 Compare P>0.05 P>0.05 P>0.05 P<0_05 P>0.05 Experimental control 5 to 29 25 78. 99 soil 2. 26 75. 72+2. 65 2. 80+0. 98 1.33+0.27 2. 78 soil 0 16 Experimental test 5 to 29 25 82. 04 soil 2. 65 79. 99+2. 66 1.83±0. 36 0. 68+0.16 2.51+0. 08 Comparison P<0.01 P<0.01 PC0.01 P<0.01 P<0.01 5 Table 4 Starting date group egg fertilization rate (%) Hatching rate (%) Breeder rate (%) February 28 to March 21 曰 Control 750 89. 5 77. 1 38. 3 February 28 From March 21 to March 21 900 test 900 89. 4 78. 4 38. 0 March 8 to March 29 曰 Control 600 89. 6 77. 8 38. 2 March 8 to March 29 曰 Test 900 89. 5 78. 1 38. 3 March 14 to April 4 曰 Control 750 89. 7 76. 9 38. 5 March 14 to 14 test 750 89. 5 77. 3 38. 4 Control 89. 6 77. 3 38. 3 Test 8 9. 5 77. 9 38. 2

Group organic matter (%) Crude protein (%) Crude ash (%) Calcium (◦/〇P (8) Control 88. 86 81. 05 83. 60 84. 95 73.42 Test 88.48 80. 82 85. 82 87. 30 79 64 [Simple diagram of the diagram 3 Figure 1 is a graph showing the egg production rate of two groups of laying hens in an experiment; Figure 2 is a graph showing the abnormal egg ratio of the two groups of laying hens in the experiment. Broken egg ratio map; 16 1313160 Figure 3 is a graph showing the feed conversion efficiency of two groups of laying hens during the experiment; and Figure 4 is a graph showing the egg rate of the two groups of laying hens during the experiment. Main component symbol description]

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Claims (1)

IJ13160 «, I public meal Λ 113334 patent application application patent scope repair five years n-rr-J . ^ .;;: thousand, patent application scope: 丨无篇琴»··一·· *·-· ,··,一* , · -·— | It . 1 1.-Cysteine-containing composition for secret manufacturing - for poultry use = way 'This feed is used to reduce the poultry The number of broken eggs produced, wherein the cysteamine-containing composition comprises (i) substantially 丨 to 95% by weight of cysteamine having a chemical formula of fox-CH2-CH2-SH or a salt thereof, and (ii) ) - money and / or - coated carrier. 2. If you apply for a patent! The use of the item, wherein the poultry hens. 3. The use of the invention of claim 4, wherein the composition comprises 18% by weight of the stabilizer. 10 15 4. The use of the patent application (4), wherein the stabilizer is selected from the group consisting of cyclodextrin or a derivative thereof. 5. The use of claim 3, wherein the composition comprises 1% by weight of the stabilizer. 6. The use of the scope of the patent application, wherein the composition further comprises a component selected from the group consisting of: a leavening agent, a fragmentation agent. Wherein the support system is a solid, wherein the support is a support in which the support is in the composition wherein the support is formed at a pH of 7', as claimed in claim 1. 8. Use as claimed in item 1 of the patent application. The poultry has a soluble coating in the intestine. 9. A multi-layered structure is exhibited in the use of the first item of the patent application. 1〇. If the application of the scope of patent application is 1. 1. Maintain insoluble under 5 to 3.5. 20 1313160 11. The use of claim 1, wherein the feed comprises other food materials selected from the group consisting of corn, soybean, yeast, fish bone meal, salt, methionine , amino acids and vitamins. 12. The use of claim 1 wherein the composition comprises substantially 30% by weight of cysteamine. 13. The use of claim 1 wherein the feed substantially comprises from 15 to 900 ppm of cysteamine. 14. The use of claim 1 wherein the feed substantially comprises 120 ppm cysteamine. Ίο 15. The use of claim 1 wherein the feed substantially comprises from 50 to 3000 ppm of the composition. 16. The use of the stabilizer and the coated carrier as claimed in claim 1 of the patent application. 17. A cysteamine-containing composition for use in the manufacture of a feed for poultry for reducing the number of broken eggs produced by such poultry, wherein the cysteamine-containing composition The substance comprises substantially 1 to 95% by weight of a cysteamine of the formula NHrCHrCHrSH or a salt thereof. 18. A method of raising poultry and reducing the number of broken eggs produced by the poultry, the method comprising at least two steps: 20 (a) - a first step which will contain (i) substantially 1 to 95 % by weight of a cysteamine having a chemical formula of 2-CHrCH2-SH or a salt thereof containing a cysteamine-containing composition, and (ii) a stabilizer and/or a coating carrier; and (b) - a second step of feeding the poultry with the feed material and the mixture of the semiquinone-containing composition obtained in step (a) of 2 1313160. The method of claim 18, wherein the mixing in step ω comprises directly mixing the composition with the feed material. 5. The method of claim 18, wherein the mixing in step (4) involves first preparing - including the semi-inspected premix, and subsequently mixing the premix with the feed material. 21. The method of claim 18, wherein the composition comprises the stabilizer and the coated support. 1 22, a method of raising a house and reducing the number of broken eggs produced by the poultry, the method comprising at least two steps: U) a first step which will contain U) substantially 1 to 95 weight Mixing a cysteamine-containing composition of cysteamine or a salt thereof having the chemical formula NHz-Cm-CHrSH; and 15 (b) a second step of feeding the poultry with the feed material and the step (a) A mixture of the obtained cysteamine-containing composition obtained. 23. A poultry feed for reducing the amount of broken eggs produced by poultry comprising a cysteamine-containing composition wherein the composition comprises substantially 20 1 to 95% by weight of the chemical formula NHrCH2-CH^ The cysteamine of SH or a salt thereof and (ii) a stabilizer and/or a coating carrier. 24. The poultry feed according to claim 23, wherein the cysteamine-containing composition further comprises from 1 to 8% by weight of the stabilizer. 25. A poultry feed according to claim 23, wherein the stabilizer is selected from the group consisting of cyclodextrin or a derivative thereof. 26. The poultry feed of claim 23, wherein the cysteamine-containing composition further comprises 10% by weight of a stabilizer. 27. The poultry feed of claim 23, wherein the cysteamine-containing 5 composition further comprises a component selected from the group consisting of: a leavening agent and a fragmentation agent. 28. The poultry feed of claim 23, wherein the system is a solid carrier. 29. The poultry feed of claim 23, wherein the carrier is a soluble coating in the intestinal tract of the poultry. 30. The poultry feed of claim 23, wherein the support exhibits a multi-layer structure in the composition. 31。 The poultry feed of claim 23, wherein the support is prepared to remain insoluble at a pH of 1.5 to 3.5. 15 32. The poultry feed according to claim 23, further comprising other food materials selected from the group consisting of corn, soybean, yeast, fish bone meal, salt, methionine, Amino acids and vitamins. 33. The poultry feed of claim 23, wherein the cysteamine-containing composition substantially comprises 30% by weight of cysteamine. 20 34. The poultry feed of claim 23, wherein the feed comprises substantially 15 to 900 ppm of cysteamine. 35. The poultry feed of claim 34, wherein the feed substantially comprises 120 ppm cysteamine. 3 6. The poultry feed of claim 23, wherein the feed substantially comprises from 4 to 13 ppm of the cysteamine-containing composition of from 50 to 3000 ppm. 37. The poultry feed according to claim 23, wherein the cysteamine-containing composition contains the stabilizer and the coating carrier. 38. A poultry feed 5 for reducing the amount of broken eggs produced by poultry comprising a cysteamine-containing composition, wherein the composition comprises substantially 1 to 95% by weight of the chemical formula NHrCH2-CH2 -SH cysteamine or a salt thereof. 39. A method for preparing a poultry feed for reducing the amount of broken eggs produced by poultry according to any one of claims 23 to 38, which comprises a cysteamine containing The step of mixing the composition with a suitable base feed material. 40. A method for reducing the number of broken eggs produced by poultry, comprising administering to the poultry a cysteamine-containing one as described in any one of claims 1 to 17 of the patent application. Composition. 15