1285120 九、發明說明： 【發明所屬之技術領域】 本發明是有關於一種吸入型藥物釋放裝置，特別是指 一種可供患者輕鬆吸藥之吸入型藥物釋放裝置。 【先前技術】 呼吸道疾病如氣喘等易因外界環境的刺激因素而引起 發作，造成患者呼吸困難。治療藥物常採“吸入型藥物，，處 方以將所需要的藥物[如支氣管擴張劑（bronchodilators)或 抗發炎藥物（Anti-inflammatory agents)等]直接送至肺中以發 揮治療效用。 目前較常使用的攜帶型的吸入型藥物約有三種使用方 式，第一種是以口含緊後直接吸入型之定量喷霧劑、第二 種是吸入之内容物是極細的藥粉、第三種是可接，，吸入輔助 时之吸入型藥物，此類吸入型藥物大多以喷霧方法吸入， 吸入輔助裔之使用，可使藥物在咽喉沉積的量減少，使藥1285120 IX. Description of the Invention: [Technical Field] The present invention relates to an inhaled drug release device, and more particularly to an inhaled drug release device which can be easily inhaled by a patient. [Prior Art] Respiratory diseases such as asthma are prone to seizures due to external environmental stimuli, causing difficulty in breathing. Therapeutic drugs often use "inhalation drugs, prescriptions to deliver the required drugs [such as bronchodilators or anti-inflammatory agents] directly to the lungs for therapeutic use. There are three types of portable inhaled drugs to be used. The first one is a direct inhalation type of quantitative spray, the second is a very fine powder, and the third is a third. Inhalation-type drugs when inhaled, most of these inhaled drugs are inhaled by spraying, and the use of inhaled aborigines can reduce the amount of drug deposited in the throat.
物送達肺内之藥量較充足，本發明係針對第三種使用方式 中的“吸入輔助器，，提供改進。 如圖1所示，是-種習知吸入辅助器1，包含有一内具 有:容置空間m之筒體u，以及一設於筒以丄上且裝填 有藥物之高壓瓶12。筒體u _端形成有一入口 ιΐ2，另一 相反端則形成有一出口 i 13，位於出口 113端之筒體11上 且該出口 113處設有 閥115。而高壓瓶12 高壓瓶12上另設有一 並設有一可供使用者口含之咬嘴114, 一可朝咬嘴114方向單向開啟之單向 則係女裝在該筒體11的入口 112處。 1285120 可供患者按壓操作之開關121，以及一可將藥物導入筒體u 中之導管122。藉此患者只要口含咬嘴114，適時按下高壓 瓶12上的開關121，即可使藥物高速喷入容置空間lu中 - 並同時產生霧化效果，此時患者只要深深呼吸即可牽引單 讀 向閥115開啟，使得已霧化的藥物可通過出口 113進而被串 者吸入。然而因筒體11之容置空間ln係呈密閉狀態，， 隨著使用者之吸氣次數，容置空間nl内負壓會愈來愈大， 以致使用者吸氣愈來愈費力。 【發明内容】 因此，本發明之目的，是在提供一種可供患者輕鬆吸 藥之吸入型藥物釋放裝置。 一本發明之吸入型藥物釋放裝置可供一容裝有藥物之儲 藥器插置，且能使該儲藥器内的藥物霧化輸出，該儲藥器 並具有一可供該藥物輸出至該吸入型藥物釋放裝置中之噴 嘴，該吸入型藥物釋放裝置包含有一殼體、一設於殼體二 4之罩體’以及一設於殼體内之第一單向閥。該殼體具有 • ❺開放端以分別形成—輸人口與—輸出Π，以及-位於輸 . ^與輸出e間之腔室。該罩體是由透氣材f所製成且設 於該殼體之輸入口處，罩體具有一開口，以及一可透過開 口而與腔室連通之暫存室。第—單向閥設於殼體的腔室中 ，且能在_用下開通。藉此利用儲藥器將藥物輸入於 =室中，進而朝暫存室方向產生霧化效果當使用者由殼 =輸出口吸氣時，將同時吸引第—單向閥順著氣流流動 。開通’使得霧化後的藥物能通過第_單㈣而由輸出 1285120 口輸出供使用者吸人，㈣罩體的可透氣性而與外界氣麼 — 1生某一程度之平衡，以減低腔室與暫存室内之負壓現象 - ，令使用者得以輕鬆吸入藥物。 * 【實施方式】 有關本毛月之月ij述及其他技術内容、特點與功效，在 以下配合參考圖式之一個較佳實施例的詳細說明中，將可 清楚的呈現。 如圖2所不，是本發明吸入型藥物釋放裝置2之第一 φ ㈣實施例’用以供-容裝有藥物之儲藥器3插置，該儲 藥器3為一填裝有粉狀藥物之高壓容器，且儲藥器3具有 一出藥口(圖中未示)、-設於出藥口處之藥物輸出控制閥31 ，以及-與該控制閥31連通而能使藥物以高速噴射輸出之 喷嘴32。該吸入型藥物釋放裝置2包含有一殼體21、一設 於殼體21 —端之罩體22,以及一設於殼體2ι内之第一單 向閥23。殼體21具有一輸入口 211與一輸出口 212，以及 一形成於其間之腔室213。該腔室213係分隔成前區段與後 • 區段，本文中定義前區段係接近殼體21之輸出口 212，而 • 後區段則接近殼體21之輸入口 211，並以第一單向閥23控 制前後區段之通斷。第一單向閥23開通時釋放之藥物可由 腔至213之後區段朝前區段流動。罩體22具有一呈中空筒 體狀之連接部221、一設於連接部221 —端且由可透氣的不 織布材質所製成之透氣部222，連接部221與透氣部222共 同界定一暫存室223。該連接部221另一端形成有一開口 224，殼體21之輸入口 211端可經由該開口 224而與暫存室 7 ⑧ 223僅The amount of the drug delivered to the lung is sufficient. The present invention provides an improvement to the "inhalation aid" in the third mode of use. As shown in Fig. 1, it is a conventional inhalation aid 1 which has an inner a cylinder u for accommodating the space m, and a high pressure bottle 12 disposed on the cartridge and filled with the medicine. The inlet u _ end is formed with an inlet ι 2, and the other opposite end is formed with an outlet i 13, at the outlet A valve 115 is disposed on the cylinder 11 of the 113 end, and the outlet 115 is provided with a valve 115. The high pressure bottle 12 is further provided with a mouthpiece 114 for the user's mouth, and a single nozzle 114 can be oriented toward the mouthpiece 114. The one-way opening is for the women's clothing at the entrance 112 of the barrel 11. 1285120 A switch 121 for the patient to press and a catheter 122 for introducing the drug into the barrel u. The mouth 114 presses the switch 121 on the high pressure bottle 12 in time to enable the medicine to be sprayed into the accommodating space lu at a high speed - and at the same time, the atomization effect is generated. At this time, the patient can pull the single read valve 115 to open as long as the patient breathes deeply. So that the atomized drug can pass through the outlet 113 and be further However, since the accommodating space ln of the cylinder 11 is in a closed state, the negative pressure in the accommodating space nl becomes larger and larger as the user inhales the number of times of inhalation, so that the user is more and more inhaled. SUMMARY OF THE INVENTION Accordingly, it is an object of the present invention to provide an inhaled drug release device that can be easily inhaled by a patient. An inhaled drug release device of the present invention can be inserted into a drug reservoir containing a drug. And capable of atomizing the drug in the drug reservoir, the drug reservoir having a nozzle for outputting the drug into the inhalation drug release device, the inhaled drug release device comprising a housing and a a cover body disposed on the casing 2 and a first one-way valve disposed in the casing. The casing has an open end to form a population and an output port, and - a transmission. The chamber is outputted between the e. The cover body is made of a gas permeable material f and is disposed at an input port of the casing. The cover body has an opening, and a temporary storage chamber that can communicate with the chamber through the opening. The first check valve is disposed in the chamber of the housing and can be used under By using the drug accumulator to input the drug into the = chamber, the atomization effect is generated toward the temporary storage chamber. When the user inhales from the shell = output port, the first check valve is simultaneously attracted to flow along the air flow. Turning on 'allows the atomized drug to pass through the first _ single (4) and output from the output 1285120 for the user to inhale, (4) the gas permeability of the cover and the outside air - a certain degree of balance to reduce Negative pressure phenomenon in the chamber and the temporary storage room - allows the user to easily inhale the drug. * [Embodiment] Regarding the monthly content of the month, the other technical contents, features and effects, in the following reference model The detailed description of the preferred embodiment will be clearly shown. As shown in Fig. 2, the first φ (four) embodiment of the inhaled drug release device 2 of the present invention is used for a drug-filled drug store. 3, the drug reservoir 3 is a high-pressure container filled with powdered medicine, and the drug storage device 3 has a medicine outlet (not shown), and a drug output control valve disposed at the medicine outlet 31, and - in communication with the control valve 31, enabling the drug to be jetted at a high speed 32 out of the nozzle. The inhaled drug release device 2 includes a housing 21, a cover 22 disposed at the end of the housing 21, and a first unidirectional valve 23 disposed in the housing 2i. The housing 21 has an input port 211 and an output port 212, and a chamber 213 formed therebetween. The chamber 213 is divided into a front section and a rear section. The front section is defined herein as being close to the output port 212 of the housing 21, and the rear section is adjacent to the input port 211 of the housing 21, and A check valve 23 controls the opening and closing of the front and rear sections. The drug released when the first one-way valve 23 is opened may flow from the chamber to the section 213 after the section toward the front section. The cover body 22 has a connecting portion 221 having a hollow cylindrical shape, a gas permeable portion 222 formed at the end of the connecting portion 221 and made of a gas permeable non-woven material, and the connecting portion 221 and the gas permeable portion 222 together define a temporary storage. Room 223. The other end of the connecting portion 221 is formed with an opening 224 through which the input port 211 end of the housing 21 can be connected only to the temporary storage chamber 7 8 223.
1285120 223連通。當第一單㈣23呈關閉狀態時，暫存室 與腔室213的後區段連通。 另外’吸入型藥物釋放裝置2更包含有一裝設於殼體 21輸出口 212處且可供使用者〇含之咬嘴μ、一與殼_ 的腔室213前區段連通且能用以過遽氣體中的細菌之滤氣 件（Bacterial filter)25，以及一筮一铟 i ) 乂及第一早向閥26。咬嘴24内具 有-連通腔室213與外界之通道241。而渡氣件25則具有 -固定在殼體上且與腔室213相通之輸入端251、與該 輸入端251相對之輸出端25 2，» 人 铷252以及一介於輸入端251與輸 出端252間之過遽層253。前述第二單向閥％可控制渡氣 件25與腔室213之通斷。 士圖2 3所示，在使用上，使用者需口含咬嘴μ並 致動控制閥31使之開啟，此時，儲藥器3内的藥物即經由 噴嘴32高速噴入殼體21之腔室213中，藉由撞擊殼體21 内壁面而能產生霧化效果，霧化後的藥物將由腔室213後 區段瀰漫至暫存室223中，當使用者吸氣時，腔室213前 區段產生負壓作用力以吸引第一單向閥23順著氣流流動方 向開啟，使得霧化後的藥物能由暫存室223、腔室213後區 段通過第一單向閥23而經由輸出口 212輸出至使用者口中 ，由於罩體22之透氣部222的可透氣性能容許空氣能進出 罩體22，進而平衡内、外壓力，避免腔室213與暫存室 223内產生過大的負壓因此使用者在吸入藥物時更為輕鬆而 不費力。 此外，如圖4所示，當使用者呼氣時，第一單向閥23 1285120 受到該呼出氣流的正壓頂推形成關閉狀態而第二單 26則反而受到該呼出氣流的正|頂推而朝遠離u咬體^ 方向開啟，使得呼出氣流能由輸入端251輸入遽氣： ’經過過濾層253的過瀘、作用後再由輸㈣252排出 此對於-些患有傳染性呼吸道疾病的使用者而言，更 效過濾細菌，防止細菌散播。 此 如圖5所示，本發明吸入型藥物釋放裝置2除了可如 上述方便使用者隨身攜帶外，如在醫療院所使用時，也可 視狀況而以面罩27取代前述咬嘴24,另外，儲藥器3上更 可設有一輸出接頭33’此時儲藥器3中可容裝液態藥物； 在使用時，可將醫療院所中高㈣氣設備4(當然也可以是 一空氣源）的輸出f路與該儲藥器3之輸出接頭33相接合， «，罩27罩置於使用者口鼻處，利用高壓氧氣高速輸入 儲藥器3中，在柏努力原理作用下於喷嘴32處產生負壓而 將液態藥物吸人高速氣體中，進而高速噴人殼體Μ之腔室 213後區段中，藉由撞擊殼體21内壁面亦能產生霧化效果 ’進而瀰漫至暫存S 223内，如此當使用者吸氣時，第一 ^向闕23因負壓作用而開通，已霧化的藥物亦能通過第一 單向閥23而由輸出口 212輸出供使用者毫不費力地吸入（ 如圖6所示）。又如圖7所示，當使用者呼氣時，第一單向 閥23形成關斷狀態’而第二單向閥％則反而受到該呼出 氣流的正壓頂推而朝遠離21殼體21方向開啟，因此，呼 出氣流能通過第二單向閥26 _氣件25過濾後由輸出端 252排出至外界。如此對於—些患有傳染性呼吸道疾病的使1285120 223 connected. When the first single (four) 23 is in the closed state, the temporary chamber is in communication with the rear portion of the chamber 213. In addition, the inhaled drug release device 2 further includes a mouthpiece μ which is disposed at the output port 212 of the housing 21 and is detachable by the user, and is connected to the front section of the chamber 213 of the case _ and can be used A Bacterial filter 25 of bacteria in the helium gas, and a first indium i) and a first early-direction valve 26. The mouthpiece 24 has a passage 241 that communicates with the chamber 213 and the outside. The gas inlet member 25 has an input end 251 fixed to the casing and communicating with the chamber 213, an output end 25 2 opposite to the input end 251, a port 252 and an input end 251 and an output end 252. Between the layers 253. The aforementioned second check valve % controls the on and off of the gas passage 25 and the chamber 213. As shown in Fig. 23, in use, the user needs to have the mouthpiece μ and activate the control valve 31 to open it. At this time, the medicine in the drug reservoir 3 is sprayed into the casing 21 at a high speed via the nozzle 32. In the chamber 213, the atomization effect can be generated by striking the inner wall surface of the casing 21, and the atomized medicine will be diffused into the temporary chamber 223 by the rear portion of the chamber 213. When the user inhales, the chamber 213 The front section generates a negative pressure force to attract the first one-way valve 23 to open in the flow direction of the airflow, so that the atomized medicine can pass through the first check valve 23 from the temporary chamber 223 and the rear section of the chamber 213. The air outlet of the air permeable portion 222 of the cover 22 allows the air to enter and exit the cover 22, thereby balancing the internal and external pressures, thereby preventing excessive generation of the chamber 213 and the temporary storage chamber 223. Negative pressure is therefore easier and less laborious for the user to inhale the drug. In addition, as shown in FIG. 4, when the user exhales, the first check valve 23 1285120 is pushed by the positive pressure of the exhaled airflow to form a closed state, and the second single 26 is instead positively pushed by the exhaled airflow. Opened away from the u bite ^, so that the exhaled air can be input to the helium by the input end 251: 'After passing through the filter layer 253, the action is discharged by the input (4) 252 to the user who has infectious respiratory diseases. In other words, it filters bacteria more effectively and prevents the spread of bacteria. As shown in FIG. 5, in addition, the inhaled drug release device 2 of the present invention can be carried by the user as described above. For example, when used in a medical institution, the mouthpiece 24 can be replaced by a mask 27 as the case may be. The medicine device 3 can be further provided with an output joint 33'. At this time, the liquid medicine can be accommodated in the medicine storage device 3. When used, the output of the high (four) gas equipment 4 (of course, an air source) can be used in the medical institution. The f-way is engaged with the output joint 33 of the accumulator 3, «, the cover 27 is placed at the mouth and mouth of the user, and is input into the accumulator 3 at high speed by high-pressure oxygen, and is generated at the nozzle 32 under the action of the cypress effort. The liquid medicine is sucked into the high-speed gas by the negative pressure, and the high-speed sprayed into the rear section of the chamber 213 of the human shell, and the atomization effect can be generated by hitting the inner wall surface of the casing 21, thereby diffusing to the temporary storage S 223 Therefore, when the user inhales, the first turn 23 is opened due to the negative pressure, and the atomized medicine can also be output through the first check valve 23 from the output port 212 for the user to effortlessly Inhalation (as shown in Figure 6). As shown in FIG. 7, when the user exhales, the first check valve 23 forms an OFF state and the second check valve % is instead pushed by the positive pressure of the exhaled airflow toward the casing 21 away from the 21 Turning on, therefore, the exhaled airflow can be filtered by the second check valve 26, the gas member 25, and then discharged to the outside by the output terminal 252. So for some people with infectious respiratory diseases
1285120 用者而言，更能有效過濾細菌，防止細菌散播。 綜上所述，本發明吸入型藥物釋放裝置i藉由殼體21 一端設有一可透氣之罩體22，以平衡使用者吸藥時，殼體 21内、外的壓力，避免殼體21内產生負壓，從而使得使用 者可以省力地輕鬆吸藥，另外，配合濾氣件26之設置，更 能將使用者所啤出的氣體過渡後才排出至外界，避免細菌 散播，故能確實達到上述本發明之目的。 准以上所述者，僅為本發明之較佳實施例而已，當不 能以此限定本發明實施之範圍，即大凡依本發明申請專利 範圍及發明說明内容所作之簡單的等效變化與修飾，皆仍 屬本發明專利涵蓋之範圍内。 【圖式簡單說明】 圖1是習知吸入輔助器示意圖； 圖2是本發明吸入型藥物釋放裝置一較佳實施例之局 部剖面示意圖； =3是該較佳實施例之作動圖一，顯示使用者吸氣時 ’第-單向閥開啟且第二單向閥關閉，霧化藥物之流動狀 態； ，圖^是該較佳實施例之作動圖二，顯示使用者呼氣時 單向閱關閉且第二單向閥開啟，使用者呼出氣流 流動狀態； 圖^ {該較佳實施例一使用態樣之示意目，顯示利用 、氧乳將儲藥器中的液態藥物高速喷入殼體中以產生 化效果之態樣； 分 10 1285120 圖6是該較佳實施例之另一使用態樣之示意圖，顯示 使用者吸氣時，第一單向閥開啟且第二單向閥關閉，霧化 藥物之流動狀態；及 顯示使 使用者 圖7是該較佳實施例之又一使用態樣示音圖 用者呼氣時，第一單向閥關閉且第二單向μ 网開啟 呼出氣流之流動狀態。 12851201285120 For the user, it is more effective in filtering bacteria and preventing the spread of bacteria. In summary, the inhaled drug release device i of the present invention is provided with a gas permeable cover 22 at one end of the housing 21 to balance the pressure inside and outside the housing 21 when the user takes the medicine, thereby avoiding the inside of the housing 21. The negative pressure is generated, so that the user can easily absorb the medicine with labor and effort. In addition, with the setting of the gas filtering member 26, the gas which the user drinks can be discharged to the outside world to avoid the spread of bacteria, so that it can be surely achieved. The above object of the present invention. The above is only the preferred embodiment of the present invention, and the scope of the invention is not limited thereto, that is, the simple equivalent changes and modifications made by the scope of the invention and the description of the invention are All remain within the scope of the invention patent. BRIEF DESCRIPTION OF THE DRAWINGS Figure 1 is a schematic view of a conventional inhalation aid; Figure 2 is a partial cross-sectional view of a preferred embodiment of the inhaled drug release device of the present invention; = 3 is an actuation diagram of the preferred embodiment, showing When the user inhales, the first check valve is opened and the second check valve is closed, and the flow state of the atomized medicine is closed. FIG. 2 is a second diagram of the preferred embodiment, showing that the user is one-way when exhaling. When the second check valve is closed and the second check valve is opened, the user exhales the flow state of the air flow; FIG. 1 is a schematic view of the use of the embodiment, showing that the liquid medicine in the drug reservoir is sprayed into the housing at a high speed by using the oxygen emulsion. FIG. 6 is a schematic view showing another use mode of the preferred embodiment, showing that when the user inhales, the first check valve is opened and the second check valve is closed. The flow state of the atomized drug; and the display allows the user to exhale when the user of FIG. 7 is another use mode of the preferred embodiment, the first check valve is closed and the second one-way μ net is opened and exhaled. The flow state of the airflow. 1285120
【主要元件符號說明】 2吸入型藥物釋放裝置 3儲藥器 4高壓氧氣設備 21殼體 22罩體 23第一單向閥 24咬嘴 25濾氣件 26第二單向閥 27面罩 3 1控制閥 32喷嘴 33輸出接頭 211輸入口 212輸出口 213腔室 221連接部 222透氣部 223暫存室 224 開口 251輸入端 252輸出端 253過濾層 ⑧ 12[Main component symbol description] 2 Inhalation type drug release device 3 Accumulator 4 High pressure oxygen device 21 Housing 22 Cover 23 First check valve 24 Mouthpiece 25 Filter member 26 Second check valve 27 Mask 3 1 Control Valve 32 nozzle 33 output joint 211 input port 212 output port 213 chamber 221 connection portion 222 gas permeable portion 223 temporary storage chamber 224 opening 251 input end 252 output end 253 filter layer 8 12