1279225 九、發明說明： 【發明所屬之技術領域】 本發明係有關於賴魏轉徵分析，尤指（但並祕於)提 供了 -對於生物體使躲射樣本傳送之特徵分析的系統及方法。 【先前技術】 糖尿病是-種麵疾病’是發生錢齡泌過少，胰臟不分 泌胰島素’献身體對於胰島素不能產生正常反應(胰&素排斥） 的狀況下所造成。糖尿病沒有治_找·糖尿病患者必須要 每曰接受病情_。射-種控财式是注織導素，例如Lantus 種胰島素-天注射數:域崎浦連續輸送。胰$侧量的不適 當會導致嚴重的副作用，包括墙過高症，也就是說血中的葡萄 糖的含量過高，轉致對於神經、血球及其赠龍官的損害。 不適當的胰A素控制也有可能導致錄過少，也就是說血中的葡 萄糖過低，而造成昏厥或甚至最糟糕的情況會巾風。由於胰島素 的配送必須配合血巾的_糖濃絲做改變，因錄尿病患者必 須經常檢視血糖濃度。 傳統上居家血糖濃度的檢測是使用血糖計量器，在數分鐘内 就能產生檢測結果。為了測定血糖的高低，受測者必須要針刺手 才日來採木小里的血液樣本；血液必須放在試紙上且插入血糖計量 為來分析血液巾㈣萄糖濃度。糖尿病患者必須根據測試結果來 1279225 調整胰島素的注射量。 “傳_萄糖檢測方式的缺點是需要採集血液樣本，過程中可 bk成刺痛以及不方便。糖尿病患者必需顧慮副作帛所產生的風 險:因«萄糖的監控是極度重要，—不具侵略性以及無痛的新 式葡萄糖檢測方式是有需要的。 【發明内容】 本案實施例提供-種不具侵略性的血糖濃度監控方法。本案 實施例也可朗來分減他錄叹非錄哺性。再者，此發 也可^使用桃射的樣本傳送，例如㈣的移除以及靜脈曲張 的移除等美容整形手術。 案實補中’其中一方法包含：偵測一生物體上的樣本； 在偵測到的樣本;收集至少一部分反射自被照射物的樣 本的輪射線；分析收_麵射，麵定生物體的特性。 =衡:所需的裝置包括一影像_器，一面鏡子，_ =:-套_測裝備’以及電子設傷。影像偵測器是被定 線到物體上，_ 鏡子是可調整來反射輕射 將第m 射11是發射第二類輻射，以及 反射:來^發射到鏡子上。姉_额是用來接受從生物體 料αΓ她射。喊子設備和影軸聰，練發射器， 兄子她貞職版樹—1料询_辨識目標 1279225 物上的樣本，且能狀射自雜侧㈣_資料來辨識目標物 的樣本’膽鏡子並將第二類輻概射在要觸的樣本；使用自 幸田射偵測衣備的輪射反射資料以分析目標物上的特徵。 口此這個衣置及方法提供—高訊號雜訊比，不需使用被引導 而來的輪射來耗損高能量，且能避免干擾。 【實施方式】 乂下敘述疋要讓^悉本技術領域者能夠使用這個發明，亦 提供此裝置㈣殊應財式及其必要餅。姉此簡領域的一 般技巧’針對此裝置的各種調整技巧十分顯而易見，^在此定義 的這些原理或許也適其他發明的實酬和翻，而不脫原來 么明的精神及見識。因此’此發明並不只侷關於此文所示之實 化例’而是力求表驗任何與此原理’特性’學說有—致性的最 大領域裡。 圖一是眼睛100的描述。此眼睛100約2· 5公分寬，2· 5公分深， 高2· 3公分。眼睛的外層12〇稱為鞏膜，約六分之一清澈且外露的 鞏膜是細。眼外的肌肉與鞏膜結合且能轉動眼睛副。有色區域 是眼睛100的瞳孔110，且位於眼睛1〇〇的第二層（例如：脈絡膜）， 也就是鞏膜的下面。脈絡膜跟鞏膜12()包含複數個血管，例如血管 130其負貝供給血液到眼睛各個不同區域。一般來說，鞏膜η。 裡頭的血管群是身體血管群裡最直接暴露於韓射的。因此，經由 !279225 血液的光譜分析得來的非侵人性分析__是最簡單也是最能 精雜行的’其必碰_眼_的血管。鞏膜⑽裡的血管 循著非直線的行徑流動，且各有不同的厚度。 圖二之方塊圖描述樣本偵測及輕射傳送裝置2〇〇，其得以偵測 ^睛10G上的樣本(Pattern)，额傳魏射到無樣本相符的眼 =00。例如，樣本侧及触傳送裝置咖可_血管⑽且傳送 符合眼睛1GG血管1_骑。較佳者，樣本侧聽射傳送裝置 200可偏]任何物體上的樣本，並將樣本的輕射傳送到該物體上， 不論疋生物鱗生物。例如’樣本_及鋪傳魏置細可偵測 一小塊木屑的樣本’並傳送與木屬樣本輻射相同的樣本輻射。又 如，樣本_及轴傳送裝置可_來__賴殘骸，並 將歹成骸的結構斷面清楚地呈現出來。 在一實施例中，樣本偵測及輻射傳送裝置2〇〇也可以在數組不 圖的樣本中’藉由事先設定的參數來選定一組。例如樣本侧及 輕射傳送震置200可以在眼球1〇〇裡選定血管13〇根據厚度、長 度、以及/或者顏色（例如··紅色）。 在另一實施例中，樣本偵測及輻射傳送裝置2〇〇測量一物體的 特欲係使用光譜分析反射自樣本的輻射。舉例來說，樣本偵測及 輻射傳送裝置可以測量在血管⑽⑽關糖濃度。樣本偵測 幸田射傳送叙置2〇〇也可以收集被反射出的輕射，例如此輻射的吸 收譜、干涉圖或是任何與其刺激來源有關的特性(例如萊曼散射， 1279225 螢先性，散卿）’這些都可職各種分析上辟要灿以調整。 ，有其他技術是用錢敍射回麵輻射。料糖以外的化學物 質(也是指分析物上的)也可以使_本_及触傳送裝置· 來進行偵測及測量。 樣本伯測及輕射傳送裝置·包含電子單元職及蓋子 p。電子單纖a，將於圖瑪五詳述，包含了她貞測目標 物上樣本的電子裝置；如果目標物尚有超過—個以上的樣本，樣 本偵測及鋪傳送裝置也可以選擇個在目標物上的特定樣 本’並將預先選定的樣本舖傳送到目標物上，同時測量在 物上至少-個以上的特徵’或是根據反射出的姉來測量目禅: ^的樣本。電子單元時可包含鎖定及解除物件樣本的功能。 好2_覆蓋在目標物上姉的照射區域。例如，蓋子_可以 蓋住眼睛_。蓋子2_可為_製或是其他合適的不透光的材料 所製。因絲子裏不透光的特性，它可以防止多餘的光輕射對 於樣本伽彳難生的干擾，影_樣本_及触傳錄置2 樣本摘測及輻射顧魏。奸聽可以是堅硬的結構也可 非堅_結構。使用非堅硬結構的的優點_層面比較廣。在 本案二施例中’盍子2〇0b可以根據一個人的臉部特徵訂製，因而 能夠密封住眼睛1〇〇且防止光輕射干擾樣本姻及輕射傳送裝置 200的樣本_、鋪傳送及特徵測定功能。 、 圖三是-樣本侧及細傳送裝置2_方塊圖。在電子單元 1279225 200a包含控制元件300 ; —輻射發射器310 ;以及一數位微面鏡裝 置320(或是其他的輻射指引裝置）；一低階的影像照明器33〇 ; 一 聚焦光學裴置360 ; —電耦合(CCD, charge-coupled device)影像 偵測為370，一光束分離器380 ;以及一套反射轄射偵測裝備39〇。 抆制元件3〇〇，將於圖四及圖五說明，係相互耦合到輻射發射器 310 ;數位微面鏡裝置32〇(或是其他的輻射指引裝置）；低階的影 像照明器330 ;聚焦光學裝置編；電麵合(CCD，charge-c〇upied device)影像偵測器37〇 ;絲分離器38〇 ;卩及回到反射輕射偵 、J衣備390。更進一步地說，控制元件3〇〇主控了輕射發射器“ο ; j位微面鏡農置320(或是其他的輕射指引裝置）；低階的影像照明 J30以及聚焦光學裝置36〇。在本案實施例中，控制元件3⑽可以 根據由反射__裝備識接收觸反射輻射，分析在輕射涵蓋 勺範圍内，目;^物上的特徵(例如葡萄糖的集中情形）。 ^射發射器310發射結構化的輕射340來口勿合目標物（例如在 = 100的血官130)上的樣本。在本案實施例，經由輕射發射器所 ^出二來的輪射报接近紅外線光譜(大約·奈米到3微米）是用來進 仃光4析。在本案另—實酬’使㈣是不同波長_射(大約 幻，朗在嫌或是聽上。透過此健其他波長的輕射 強的效果。此細是在控制元件3_驗之下，從數位微面 兄f置32G(可馳、金或是齡的材質）反賴光束分離器380， 再稭由Lt、光學健_反_目標物上的樣本。當然，其他藉由 1279225 輕射發射11310來”導服射傳送π的技術亦無不可。在本案另一實 加例’輪射發導引*置可以由數位微面鏡裝置％晰取代。例如， 液晶面板(LCD Panel)可以时選取輻射發射器發射的區塊輻 射。再者’输發射H31Q可自成—輻射導引裝置，因為它可以被 轉接到200a的電子裝置部分，使輻射發射在鏡子32{)或是其 他裝置不存在的情形下，將鋪導引到目標物上。 不同於輻射發射器31〇，低階的影像照明器33〇發射低階輻 射。更詳細的說，在本案實施例，被發射絲的輻射是在反射輻 射偵測裝備39G的偵測範圍之外但卻是在CCD(charge—c〇upled device)影像偵測器370的偵測範圍之内。例如，影像照明器33〇可 以包含一低階的藍色或綠色的發光二極體。低階的影像照明器33〇 所發射出來的是波長約5GG奈米的可見韓射。影像照明器33〇所發 射出來的低階輻射照亮了目標物上的樣本。 控制元件300，結合CCD(charge-coupled device)影像偵測器 370 ’使用反射自目標物上的低階輻射來偵測目標物上的樣本。如 果目標物上有多於一的樣本，控制元件3〇〇也可以依照是先設定的 參數來做選擇。根據偵測及選擇的結果，控制元件3〇〇可以控制數 位微面鏡320或是其他的輻射導引裝置的移動，使得輻射發射器 310所發射出來的輻射可以追蹤目標物上被選定的樣本。 光束分離器380將反射回來的輻射350分成兩道光束。其中的 一道光束衝擊反射輛射偵測裝備390，另一道光束衝擊(XD影像偵 1279225 測器370。如上所述’控制元件3〇〇結合⑽影像偵测器·，利用 被反射出的輕射來判定樣本的位置_制數位微面鏡3酬而使 付輕射發射$31G所發射出來的韓射追縱被侧到的樣本中制元 件_吏用反射幸畐_測裝備39〇所接收到的輕射來分析特^例 如使用光譜分析技術在物體的濃縮程度或物體的樣本上，對此， 圖六將有更進一步的說明。 圖四描述了本案實施例的電子控制元件3〇〇的方塊圖。當我們 選擇使用其他特別的應用方式時，有一點是我們應該設想妓 籲 的’就是構成此電子控制元件300的每個部分除非已經被指定用在 某種硬體或軟體上’不然它們應該是要能用在所有處理系統與其 相容的硬體或軟體或其他組合中。 電子控制元件包含了 一中央處理器（CpU)4〇5 ;工作記憶體 410，永續§己憶體42〇 ;輸入/輸出介面43〇 ;顯示裝置44〇以及輸入 衣置450，以上裝置都能藉由系統匯流排互相通聯。中央處理 杰咖)45()可以包含-英代祕騰微處理器，—摩托羅拉p_pc鲁· 倣處理器，或是任何其他能夠處理儲存在永續記憶體420内軟體的 μ 處理為。工作記憶體41〇裡頭可能包括隨機存取記憶體(麵）、其 他形式的可碩寫記憶體或綜合記憶體。永續記憶體420包含一些即 使在電子控制元件300關掉之後還可以保存資料的硬體，例如：硬 式磁碟機、唯讀記憶體，或其他類型的記憶體和综合式記憶體。 透過有線或無限的技術，I/O介面43〇可與輻射放射器310 ;或數位 12 1279225 ;或低階影像照明器；或聚焦光學裝置編；或影 _射裝侧交互私在-起。顯示麵可包 +液屬OXD)或其他顯示裝置。輸人裝置侧可能包括一 2小型鍵盤、其他輸4置或綜合型的輸人_。此發明的 貝關中’電子控制轉3_含—可以發出聽覺訊息的擴音器。 廷擴音器可能取代顯示器物或只是額外附加於上。 熟悉本技藝人场承認㈣元件勘也包含額外的錢，例如 ，路連接、額外的記憶體、額外的處理器、區域網路、透過硬體 官道傳輸資訊的輸入/輸出線路、或内部網路和外部網路等等。熟 悉本技藝人士也會承認財柯料可駿由電子控麻件細以 其他方式接收或儲存。 圖五疋個解釋永績§己憶體42〇的方塊圖，永續記憶體包括 y輻射發射引擎500 ; -輻射導向引擎51(); 一照明引擎漏；一光 學引擎咖；-樣本選擇引擎娜；—樣本選擇參數·;回饋引擎 60 ’刀析引擎570。輪射放射引擎5〇〇控制輻射發射器31〇發射 在只關上的輻射波長(輻射發射器剔可發出各種不同波長的輕 射在實施例上)聽射發㈣時間。連接回饋引擎5_輻射導向 引擎510可控制數位微面鏡32〇，或其他輻射導向裝置的定位(例如 由幸田射發射裔310出來的輻射可查出一物體(眼睛1〇〇)上的所需被 偵测的樣本(血管130)。 照明引擎520在兩方面上控制低階影像照明設備33〇的功能， 13 1279225 疋放射在貫施例上的波長(低階影像照明裝置33〇可發射各種不 同波長的細在實闕上），另-是輻射發射時間。光學引擎咖 控制著聚线學〇,因聽概射崎發出騎構性的輕 射340可聚焦在物體上’例如眼睛⑽。樣本選擇引擎⑽可選擇由 低1¾衫像照職置咖酬，且由(XDf彡像伽彳器聊反映出的樣 本此遠擇過私疋基於儲存在樣本選擇參數裡頭的參數決定。 可能的參數鮮是像在某寬度細喊某長度顧⑽樣本的參 數。參數若能包含事先設定範_任何可㈣數字，或沒有任何 上限或下限是最好的了。 回饋引擎56G決定所選樣本的位置，且送座射繼愧射導向 引擎51G，因此輕射導向引擎51Q可引導由輕射發射器_發向樣本 的輻射。_引擎通常執行這鑛定及傳送，例如每秒在實施例 上200次’所以即使物體是移動的，數位微面鏡32〇或其他輕射導 向裝置仍可追查到樣本，因此雖有移動，鋪發射器⑽所發射出 的輻射維持照射在樣本上。 分析引擎570根據反射輕射偵測裝備39〇所接收的反射輕射 350 ’可計算所選樣本或物體的至少一樣特性。在此發明的;施例 中’分析引糊0光譜分析去測定所職本上所欲分析物的濃 縮程度。例如分析引擎570使用光譜分析去決定目崎咖裡的血管 130的濃縮葡萄糖。分析引擎570運用技術在葡萄糖❸光譜分析， 或其他在美國第6, G61，582號專利的提到的分析物(在此作為參考 14 1279225 用）。其他可使用分析儀570揭露關於光學檢測技術的專利包含美 國第6, 025, 597; 6, 026, 314; 6, 028, 311; 6,151，522; 6,181，957; 6,188, 477; 6, 246, 893;及6, 276, 798號專利也在參考資料的範圍 内。其他分析引擎570可使用的技術已經被刊登在許多被專家認 可的期刊。例如歐馬卡利爾所著之”分光學與臨床觀點之非侵略性 葡萄糖檢測π (臨床化學45:2，1999);吉爾翁運等所著之”葡萄糖 /辰度在为散媒介的光學測1’’（第二十屆國際電氣和電子工程師協 會會Λ，藥物工程及生物社會工程；第二十版，第四條，西元1998 _ 年）。以及費德瑞克漢等所著之”使用NIR光譜人類血清所產生的葡 萄糖多變量決策”（國際電氣和電子工程師協會會議，1994)，也在 參考項目之列。以上文獻簡露了分析引擎57_分析功能應用。 圖六是一流程圖敘述了一輻射樣本傳送的方法6〇〇以及以反射輻 射為基礎的分析。首先，第-種的低階輻射被發射出來(⑽）。這 種輻射可崎Μ鍵性__離(也就是超岐射輻射偵測裝 備39〇的侧距離，但是在CCD影像偵測器37〇的偵測範圍之内）。鲁 例如，如果反射輻射偵測裝備390偵測到_鋪、低階的輕射可 以包含-㈣的綠色或藍色的發光二鋪所發出來的光。再來， 建議(615)使用者將蓋子2_覆蓋在目標物上(也就是人的眼睛 上）。建議將蓋子20013覆蓋在任何有樣本的目標物上。再者，一般 ，為方法_里頭不用納入提議⑹5)是比較好的。提議⑽)最好 疋透過聽覺或視覺上的肋，或其他技術(像是㈣反應）來完成。 15 1279225 在提議《⑸後，接著要檢查一理想的位置在哪裡(⑽）。例如眼 睛一百的鞏膜或脈絡膜可檢查⑽）出—條或多條血管。接著，確 認想要哪舰構或樣本卿）。假如社純本岐，可根據事先 设定的參細如厚度、顏色(紅色)）或樣本的長度，來判別卿 真正要的樣本是職。若樣本⑽)未被確認出來(卿，提議(6⑸ 和檢驗(620)這兩個步驟就一直重複直到確認出一適當的樣本 (625)為止。 7 -適當的樣本被確認(625)出來後，第二類姉發射出去(635)鲁 且導向⑽）目標結構或樣本。這韓射的目的可能是為了檢驗(例 如光譜分析）’或侵餘脫落，或凝結等。若轄射是為了檢驗，則會 =_昌射在内。若輕射是為了侵舰落或凝結，則此輕射是高能 里的輪射線’例如其波長可能綱而。檢驗(62Q)，確認⑽），發 射輻射(635)此三步驟係以一頻率重覆，例如每秒次，致使輻 射能追縱到任何特徵物的移動。例如，如果眼睛正在移動，檢驗 (62〇) |^、(625)及發射幸虽射(^⑹這王道步驟將追縱到血管 鲁— 130，且即使在移動當中仍可持續將輕射作用在血管⑽上。 ' (640)若為一凝結或脫落的過程，輻射（645)則依裝置的需要 持續放射-段時間。輕射發射(645)結束後，關掉(咖)機器測， 則方法600結束。 (640)若為檢驗的過程，放射(635)過後反射回來的輕射將被 聚集(655)在-起，接著經過過遽⑽）區分出一特定分析物的光 16 1279225 譜特性。過濾（660)後，這些過濾的資料會被套用（665) —組數學 模式去測定分析物的濃縮程度。則最後結果產生（67〇)並以聽覺或 視覺方式呈現，例如透過顯示器440。決定分析物的濃縮程度（例 如葡萄糖濃縮）是透過光譜分析，其内容詳見美國專利第 6, 061，582號，在此亦提出以供參考。於是乎，方法6〇〇結束。 上述所有提出的實施例說明都是以舉例的方式呈現，而且有 關裝置的變動或調整可能都必須依照上述的指示。例如此本案實 施例可能用在葡萄糖偵測以外的其他目的。此外，此發明所有纪 組成零件必觀用在程式化_數位電腦，或是特定的積體電 ^ =統互她的_辑__絡。連結可透娜 ===_ ^___姆太耗縣 此或限制太夕。本案申請專利範圍如附。1279225 IX. Description of the invention: [Technical field to which the invention pertains] The present invention relates to a Lai Wei transfer analysis, and more particularly, but not exclusively, to a system and method for analyzing characteristics of a living body for transmitting a sample. . [Prior Art] Diabetes is a type of disease that occurs when the age of the child is too low, and the pancreas does not separate insulin. The body is caused by a condition in which the insulin does not produce a normal reaction (pancreas & eliminator rejection). Diabetes is not cured. _ Finding patients with diabetes must receive a condition every time. The injection-type control method is a woven guide, such as the Lantus insulin-day injection number: the continuous delivery of the domain. Discomfort in the amount of the side of the pancreas can cause serious side effects, including wall hyperactivity, which means that the amount of glucose in the blood is too high, causing damage to the nerves, blood cells and their dragons. Inappropriate pancreatic A control may also result in less recording, which means that the glucose in the blood is too low, causing fainting or even the worst conditions. Since the delivery of insulin must be changed in conjunction with the smear of the bloodstain, it is necessary to check the blood glucose concentration frequently for patients with urinary tract. Traditionally, home glucose levels have been measured using a blood glucose meter that produces test results in minutes. In order to determine the level of blood sugar, the subject must take acupuncture hands to collect the blood sample of Mu Xiaoli; the blood must be placed on the test paper and the blood glucose meter is inserted to analyze the blood sugar concentration of the blood towel (4). Diabetes patients must adjust the amount of insulin injected according to the test results 1279225. The shortcoming of the method of detecting glucose is that it needs to collect blood samples, which can cause tingling and inconvenience in the process. Diabetes patients must be concerned about the risks caused by the side effects: because the monitoring of glucose is extremely important, Invasive and painless new glucose detection methods are needed. [Summary of the Invention] The present embodiment provides a non-aggressive blood glucose concentration monitoring method. The embodiment of the present invention can also be used to reduce his non-recording. Furthermore, this hair can also be transmitted using a sample of peach shots, such as (4) removal and removal of varicose veins, etc. One of the methods includes: detecting a sample on an organism; Detected samples; collect at least a portion of the ray from the sample that is reflected from the object being irradiated; analyze the _ 面 , , , , , , = = = = = = = = = = = = = = = = = = = = = = = = = = =: - Set _ test equipment ' and electronic damage. Image detector is aligned to the object, _ mirror is adjustable to reflect light shot, mth shot 11 is emitted second type of radiation, and reflection: come ^发On the mirror. 姊 _ _ is used to accept from the biological material α Γ her shot. Shouting equipment and shadow axis Cong, practice transmitter, brother her derelict version of the tree - 1 inquiry _ identification target 1279225 sample on the object And can shoot from the miscellaneous side (four) _ data to identify the target sample 'biliary mirror and the second type of radiation is projected on the sample to be touched; use the shot reflection data from the Kodakfield detection clothing to analyze the target The characteristics of the object. This clothing and method provides a high signal noise ratio, without the use of guided shots to consume high energy, and can avoid interference. [Embodiment] It is obvious that those skilled in the art can use this invention, and also provide the device (4) special financial formula and its necessary cake. The general skill in this field is 'the various adjustment techniques for this device are very obvious, ^ these principles are defined here Perhaps it is also suitable for the remuneration and reversal of other inventions, without the spirit and insight of the original Ming. Therefore, 'this invention is not only about the actual example shown in this article' but seeks to test any 'characteristics' with this principle. Sexuality In the largest field, Figure 1 is a description of the eye 100. This eye 100 is about 2.5 centimeters wide, 2.5 centimeters deep, and 2. 3 centimeters high. The outer layer of the eye 12 is called the sclera, about one-sixth of which is clear and The exposed sclera is fine. The extraocular muscles are combined with the sclera and can rotate the eye pair. The colored area is the pupil 110 of the eye 100 and is located in the second layer of the eye 1 (eg, the choroid), that is, under the sclera. The choroid and sclera 12() contain a plurality of blood vessels, for example, the blood vessels 130 and the negative shells supply blood to various regions of the eye. Generally, the sclera η is the most direct exposure of the body vascular group to the Korean shot. The non-invasive analysis obtained from the spectral analysis of the blood of 279225 __ is the simplest and most versatile blood vessel. The blood vessels in the sclera (10) follow a non-linear path. And each has a different thickness. The block diagram of Figure 2 depicts a sample detection and light-transmitting device 2, which is capable of detecting a sample on the 10G, and a pre-transmission to the eye with no sample matching =00. For example, the sample side and the touch device can be vascular (10) and delivered in accordance with the eye 1GG blood vessel 1_riding. Preferably, the sample side audible delivery device 200 can bias the sample on any object and transmit the light of the sample to the object, regardless of the squama. For example, 'sample _ and spread the sample to detect a small piece of sawdust' and transmit the same sample radiation as the genus sample. For example, the sample _ and the shaft transfer device can _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ In one embodiment, the sample detection and radiation delivery device 2 can also select a group by a parameter set in advance in a sample of the array. For example, the sample side and the light-transmitting transducer 200 can select a blood vessel 13 in the eyeball 1 depending on thickness, length, and/or color (e.g., red). In another embodiment, the sample detection and radiation delivery device 2 measures the characteristics of an object using spectral analysis of the radiation reflected from the sample. For example, the sample detection and radiation delivery device can measure the concentration of sugar in the blood vessels (10) (10). The sample detection Koda field transmission can also collect the reflected light, such as the absorption spectrum of the radiation, the interferogram or any characteristics related to its source of stimulation (eg Lehman scattering, 1279225 fluorescing,散卿) 'These are all available for various analyses. There are other techniques that use money to report back radiation. Chemical substances other than sugar (also referred to as analytes) can also be detected and measured using _ this _ and the touch transmission device. Sample test and light delivery device · Includes electronic unit and cover p. The electronic single fiber a, which will be detailed in Tuma 5, contains the electronic device that she speculates on the sample on the target; if there are more than one sample in the target, the sample detection and spreading device can also be selected. A specific sample on the target 'and delivers a pre-selected sample to the target while measuring at least one or more features on the object' or a sample based on the reflected enthalpy: ^. The electronic unit can include the function of locking and releasing the sample of the object. Good 2_ covers the illuminated area on the target. For example, the cover _ can cover the eyes _. The lid 2_ can be made of _ or other suitable opaque material. Due to the opaque nature of the silk, it can prevent unwanted light and light radiation from interfering with the gamma of the sample, and the sample_sample and touch-recording 2 sample extraction and radiation. The rap will be either a hard structure or a non-hard structure. The advantages of using a non-hard structure are relatively wide. In the second embodiment of the present case, 'scorpion 2〇0b can be customized according to a person's facial features, so that it can seal the eyes 1〇〇 and prevent light light from interfering with the sample and the sample of the light delivery device 200. And feature measurement function. Figure 3 is a block diagram of the sample side and the fine transfer device 2_. The electronic unit 1279225 200a includes a control element 300; a radiation emitter 310; and a digital micro mirror device 320 (or other radiation directing device); a low-order image illuminator 33A; a focusing optical device 360 ; - CCD (charge-coupled device) image detection is 370, a beam splitter 380; and a set of reflective ray detection equipment 39 〇. The clamping element 3〇〇, as illustrated in Figures 4 and 5, is coupled to the radiation emitter 310; the digital micro-mirror device 32 (or other radiation guiding device); the low-order image illuminator 330; Focusing optical device editing; CCD (charge-c〇upied device) image detector 37〇; wire separator 38〇; 卩 and back to reflection light shot, J clothing 390. Furthermore, the control element 3 〇〇 hosts the light emitter "ο ; j-position micro-mirror 320 (or other light-directing device); low-order image illumination J30 and focusing optics 36 In the embodiment of the present invention, the control element 3 (10) can analyze the characteristics of the object (for example, the concentration of glucose) in the range of the light-spraying scoop according to the received reflection radiation by the reflection__ equipment. The transmitter 310 emits a structured light shot 340 to a sample that does not conform to the target (e.g., at a blood donor 130 of = 100). In the present embodiment, the round shot from the light emitter is approached. Infrared spectroscopy (about nanometer to 3 micrometers) is used to enter the light 4 analysis. In this case another - the actual reward 'make (four) is a different wavelength _ shot (about illusion, lang in the suspicion or listen to. Through this health other The effect of the light-wavelength of the wavelength. This is the result of the control element 3_, from the digital micro-faced f set 32G (coach, gold or age material) against the beam splitter 380, and then by the Lt , optical health _ anti _ sample on the target. Of course, other light shots of 12110 by 1279225 "The technique of guiding the transmission of π is also indispensable. In this case, another example of the 'radiation guidance' can be replaced by a digital micro-mirror device. For example, the LCD panel can select radiation. The block emits radiation from the transmitter. In addition, the 'transmission H31Q can be self-contained—the radiation guiding device, because it can be switched to the electronic device part of 200a, so that the radiation is emitted in the mirror 32{) or other devices do not exist. In the case of the situation, the shop is guided to the target. Unlike the radiation emitter 31〇, the low-order image illuminator 33〇 emits low-order radiation. In more detail, in the embodiment of the present invention, the radiation of the emitted wire is outside the detection range of the reflected radiation detecting device 39G but is detected by the CCD (charge-c〇upled device) image detector 370. Within the scope. For example, the image illuminator 33A may comprise a low order blue or green light emitting diode. The low-order image illuminator 33 发射 emits a visible Korean shot with a wavelength of about 5 GG nm. The low-order radiation emitted by the image illuminator 33 illuminates the sample on the target. Control element 300, in conjunction with CCD (charge-coupled device) image detector 370', uses low-order radiation reflected from the target to detect samples on the target. If there is more than one sample on the target, the control element 3〇〇 can also be selected according to the parameters set first. Based on the results of the detection and selection, the control element 3 can control the movement of the digital micro-mirror 320 or other radiation guiding means such that the radiation emitted by the radiation emitter 310 can track the selected sample on the target. . Beam splitter 380 splits the reflected radiation 350 into two beams. One of the beams impacts the reflection detection device 390, and the other beam strikes (XD image detection 1279225 detector 370. As described above, 'control element 3〇〇 combines (10) image detectors, using the reflected light shot To determine the position of the sample _ digital micro-mirror 3 paid for the light shot launch $31G emitted by the Korean shot tracking side of the sample in the sample _ 吏 反射 反射 畐 畐 畐 畐 畐 〇 〇 〇 〇 〇 The light shots to analyze the characteristics of the object, such as the degree of concentration of the object or the sample of the object, which will be further illustrated in Figure 6. Figure 4 depicts the electronic control element of the embodiment of the present invention. Block diagram. When we choose to use other special application methods, one thing we should assume is that each part of the electronic control component 300 is constructed unless it has been designated for use on a certain hardware or software. Otherwise they should be used in all processing systems compatible with hardware or software or other combinations. Electronic control components include a central processing unit (CpU) 4〇5; working memory 410, forever §Reference 42〇; input/output interface 43〇; display device 44〇 and input device 450, the above devices can be connected to each other through the system bus. The central processing Jieba) 45 () can contain - British secret Teng microprocessor, Motorola p_pc Lu imitation processor, or any other μ processing that can handle software stored in persistent memory 420. The working memory 41 may include random access memory (face), other forms of rewritable memory or integrated memory. Perpetual memory 420 includes hardware that can hold data even after electronic control unit 300 is turned off, such as a hard disk drive, read only memory, or other types of memory and integrated memory. Through wired or infinite technology, the I/O interface 43 can be privately connected to the radiation emitter 310; or the digital 12 1279225; or the low-order image illuminator; or the focusing optics; The display surface can be packaged with + liquid OXD) or other display devices. The input device side may include a small keyboard, other input or integrated type. In this invention, the Beiguan 'electronic control turn 3_ contains a loudspeaker that can emit an audible message. The megaphone may replace the display or just add it to it. Familiar with this art field, acknowledging that (4) component surveys also include additional money, such as road connections, additional memory, additional processors, regional networks, input/output lines that transmit information through hardware channels, or intranets. Roads and external networks, etc. Those skilled in the art will also recognize that the money can be received or stored in other ways by electronic control. Figure 5 is a block diagram explaining the permanent performance § Remembrance 42〇, the persistent memory includes the y radiation emission engine 500; - the radiation steering engine 51 (); a lighting engine leak; an optical engine coffee; - sample selection engine Na; - sample selection parameter ·; feedback engine 60 'knife engine 570. The radiation emission engine 5 〇〇 controls the radiation emitter 31 〇 to emit at the wavelength of the radiation that is only turned off (the radiation emitter can emit light of various wavelengths on the embodiment) to listen to the emission (four) time. The connection feedback engine 5_radiation steering engine 510 can control the positioning of the digital micro-mirror 32A, or other radiation guiding devices (for example, the radiation from the Koda Shots 310 can detect an object (eye 1)) The sample to be detected (vessel 130). The illumination engine 520 controls the function of the low-order image illumination device 33〇 in two aspects, 13 1279225 疋 the wavelength emitted on the embodiment (the low-order image illumination device 33 can emit The different wavelengths of the fine on the real), and the other is the radiation emission time. The optical engine controls the polyline learning, because the listening light can make a riding light 340 can focus on the object 'eg eye (10) The sample selection engine (10) can be selected from a low 13⁄4 shirt like a photo, and the sample that is reflected by the XDf gamma chatter is determined based on the parameters stored in the sample selection parameters. The parameters are rarely like the parameters of a certain length (10) sample in a certain width. If the parameter can contain the preset _ any (four) number, or no upper or lower limit is the best. The feedback engine 56G determines the selected sample. Bit And the ejector is directed to the steer-steering engine 51G, so the light-guided engine 51Q can direct the radiation emitted by the light-emitting transmitter _ to the sample. The engine typically performs this sizing and transmission, for example 200 per second on the embodiment. Secondly, so even if the object is moving, the digital micro-mirror 32 〇 or other light-guided device can still trace the sample, so even if there is movement, the radiation emitted by the spreader (10) is kept on the sample. Analysis Engine 570 According to the reflected light-light detection device 39〇 received reflection light 350' can calculate at least the same characteristics of the selected sample or object. In the invention, the analysis analyzes the reference 0 spectrum analysis to determine the position The degree of concentration of the desired analyte. For example, the analysis engine 570 uses spectral analysis to determine the concentrated glucose of the blood vessels 130 in the Miyazaki. The analysis engine 570 uses techniques in the glucosinium spectroscopy, or other US Patent No. 6, G61, 582. The mentioned analytes are used herein as reference 14 1279225. Other patents that may be disclosed using the analyzer 570 for optical detection techniques include U.S. Patent Nos. 6,025,597; 6,026,314; 6, 0, 311; 6, 151, 522; 6, 181, 957; 6, 188, 477; 6, 246, 893; and 6, 276, 798 are also within the scope of the reference. Other techniques available to the analysis engine 570 have been Published in many journals recognized by experts, such as Omar Calier's "non-aggressive glucose detection π in optical and clinical perspectives (Clinical Chemistry 45:2, 1999); Gildon Yun et al." / Chen Du is in the optical measurement of the media 1'' (The 20th International Institute of Electrical and Electronics Engineers Association, Pharmaceutical Engineering and Biosocial Engineering; 20th Edition, Article 4, BC 1998 _ year). And the “multivariate decision making of glucose produced by human serum using NIR spectra” by Federekhan et al. (International Institute of Electrical and Electronics Engineers Conference, 1994) is also included in the reference project. The above document exemplifies the analysis engine 57_analysis function application. Figure 6 is a flow chart depicting a method 6 of radiating sample transmission and analysis based on reflected radiation. First, the first-order low-order radiation is emitted ((10)). This radiation can be rugged (ie, the side distance of the super-radiation detection device 39〇, but within the detection range of the CCD image detector 37〇). For example, if the reflected radiation detecting device 390 detects a _paste, a low-order light shot may include - (iv) green or blue illuminating light. Again, it is recommended (615) that the user covers the cover 2_ on the target (i.e., on the person's eyes). It is recommended to cover the cover 20013 on any object having a sample. Furthermore, in general, it is better to not include the proposal (6) 5) for the method _. Proposal (10)) is best done through auditory or visual ribs, or other techniques (like (4) reactions). 15 1279225 After proposing "(5), it is necessary to check where an ideal position is ((10)). For example, one hundred or more of the sclera or choroid of the eye can examine (10) out a strip or a plurality of blood vessels. Next, confirm which ship or sample you want.) If the society is purely based on the pre-set parameters such as thickness, color (red) or the length of the sample, the actual sample to be determined is the job. If sample (10)) is not confirmed (Qing, the two steps of proposal (6(5) and test (620) are repeated until an appropriate sample (625) is confirmed. 7 - After the appropriate sample is confirmed (625) The second type of 姊 emits (635) Lu and directs (10) the target structure or sample. The purpose of this shot may be to test (eg, spectral analysis) or to invade, or condense, etc. If the shot is for inspection , will be = _ Chang shot. If the light shot is to invade the ship or condense, then this light shot is a high-energy round of radiation 'for example, its wavelength may be the main. Inspection (62Q), confirm (10)), emit radiation (635) These three steps are repeated at a frequency, such as every second, causing the radiant energy to track the movement of any feature. For example, if the eye is moving, check (62〇) |^, (625) and launch, although the shot (^(6) will be traced to the vascular Lu-130, and it will continue to be light-light even if it is moving. On the blood vessel (10). ' (640) If it is a process of condensation or shedding, the radiation (645) will continue to radiate for a period of time depending on the needs of the device. After the end of the light emission (645), the machine is turned off. Then method 600 ends. (640) If it is the process of inspection, the light shot reflected back after the emission (635) will be aggregated (655), and then passed through the 遽 (10) to distinguish the light of a particular analyte 16 1279225 Spectral characteristics. After filtering (660), the filtered data is applied (665) - a mathematical model to determine the concentration of the analyte. The final result is then generated (67 〇) and presented in an audible or visual manner, such as through display 440. The degree of concentration of the analyte (e.g., glucose concentration) is determined by spectroscopic analysis and is described in detail in U.S. Patent No. 6,061,582, the disclosure of which is incorporated herein by reference. So, the method 6 is over. All of the above-described embodiments are presented by way of example, and variations or adjustments of the device may be in accordance with the above. For example, this embodiment of the present invention may be used for purposes other than glucose detection. In addition, all the components of this invention must be used in stylized _ digital computers, or a specific integrated system ^ = _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ Link to Corona ===_ ^___ M too consumption county This or limit Tai Xi. The scope of the patent application in this case is attached.
17 1279225 【圖式簡單說明】 本案得藉由下列圖式及詳細說明，俾得一更深入之了解，但並非 用以限定本發明之實施方式及其他可能的變更設計： 圖一：本案較佳實施例之眼睛的圖示； 圖二：本案較佳實施例之樣本偵測及輻射傳送裝置； 圖三··本案較佳實施例之圖二裝置的方塊圖； 圖四：本案較佳實施例之敘述圖二裝置中的電子控制系統的方塊 圖； 圖五：本案較佳實施例之敘述圖二裝置的永續記憶體的方塊圖· 圖六·本案較佳實施例之根據反射的輻射，解釋輻射的樣本傳、关 及其分析的流程圖。 之 【主要元件符號說明】 眼睛100 瞳孔110 鞏膜12〇 血管130 樣本偵測及輻射傳送裝置200 電子單元200a 蓋子部分200b 輻射發射器310 低階的影像照明器330 反射回來的輻射350 電耦合影像偵測器370 控制元件300 數位微面鏡裝置32〇 結構化的輻射340 聚焦光學裝置360 光束分離器380 1279225 反射輻射偵測裝備390 中央處理器（CPU)405 永績記憶體420 顯示裝置440 系統匯流排460 輻射發射引擎500 照明引擎520 樣本選擇引擎540 回饋引擎560 工作記憶體410 輸入/輸出介面430 輸入裝置450 輻射導向引擎510 光學引擎530 樣本選擇參數550 分析引擎57017 1279225 [Simplified description of the drawings] The following drawings and detailed descriptions of the present invention will be understood, but are not intended to limit the embodiments of the present invention and other possible modifications. FIG. Figure 2 is a block diagram of a preferred embodiment of the present invention; Figure 3 is a block diagram of the device of the preferred embodiment of the present invention; Figure 4: Preferred embodiment of the present invention BRIEF DESCRIPTION OF THE DRAWINGS FIG. 2 is a block diagram of an electronic control system in a device; FIG. 5 is a block diagram of a preferred embodiment of the present invention; FIG. 6 is a block diagram of a permanent memory of the device. FIG. A flow chart explaining the transmission, closure and analysis of the sample of radiation. [Main component symbol description] Eye 100 pupil 110 Scleral 12 fistula 130 Sample detection and radiation transfer device 200 Electronic unit 200a Cover part 200b Radiation emitter 310 Low-order image illuminator 330 Reflected radiation 350 Electrically coupled image detection 370 control element 300 digital micro-mirror device 32 〇 structured radiation 340 focusing optical device 360 beam splitter 380 1279225 reflected radiation detection equipment 390 central processing unit (CPU) 405 permanent memory 420 display device 440 system convergence Row 460 Radiation Launch Engine 500 Lighting Engine 520 Sample Selection Engine 540 Feedback Engine 560 Working Memory 410 Input/Output Interface 430 Input Device 450 Radiation Steering Engine 510 Optical Engine 530 Sample Selection Parameters 550 Analysis Engine 570
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