TWI228593B - Compounds for immunodiagnosis of prostate cancer and methods for their use - Google Patents

Abstract

Compounds and methods for diagnosing prostate cancer are provided. The inventive compounds include polypeptides containing at least a portion of a prostate tumor protein. The inventive polypeptides may be used to generate antibodies useful for the diagnosis and monitoring of prostate cancer. Nucleic acid sequences for preparing probes, primers, and polypeptides are also provided.

Description

1228593 A7 Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs 5. Description of the invention (1) Technical scope The present invention is generally related to the treatment and monitoring of prostate cancer. The invention relates more particularly to polypeptides comprising at least a portion of a prostate protein. These peptides can be used to produce compounds, such as antibodies, that can be used in patients to diagnose and treat retinocarcinoma, as well as other possible tumor types. BACKGROUND OF THE INVENTION Among men, prostate cancer is the most common type of cancer, estimated at approximately 30% of men over 50 years of age. Overwhelming clinical evidence shows that prostate cancer in humans has a tendency to metastasize to the bones, and that Obviously, the disease will inevitably progress from androgen-dependent to androgen-uncontrollable conditions, leading to increasing patient mortality. This epidemic is currently the second leading cause of cancer 2 deaths in American men. Although the diagnosis of m disease There are quite a few studies on treatment, and prostate cancer is still not easy to detect and treat. Usually, treatment is based on surgery and / or radiation therapy, but these methods are ineffective for most percentages of cases. Two have been previously identified Prostate-specific proteins _ prostate specific antigen (PSA) and prostatic acid phosphatase (PAP) _ limit the possibility of diagnosis and ▲. For example, PSA content is not always correlated with the presence of prostate cancer. The percentage in this case is positive, 勹 / benign prostatic hypertrophy (BPH). In addition, PSA measures 値 and prostate System, but does not represent the extent of metastasis. 'Therefore, there is a need for improved and diagnostic methods of prostate cancer in this technique. V' still invention summary-4-This paper size applies the Chinese National Standard (CNS) A4 specification (210X297 (Mm) (Please read the precautions on the back again: this page}-Installation, 11-line 1228593 Consumer Cooperatives of the Central Bureau of Standards, Ministry of Economic Affairs, A7 B7 V. Description of the invention (2) The present invention provides immunological diagnosis of prostate cancer. Methods, and toolsets used in such methods. The disclosed polypeptide includes an immunogenic portion of at least one prostate tumor protein, or a variant of the protein, the only difference being the retention replacement and / or modification Wherein the prostate tumor protein includes an amino acid sequence encoded by a DNA molecule, the DNA is divided into a sequence selected from the group consisting of 2, 3, 5 «107, 109-11, 115-171, 173» 175, 177, 179 No. 224 and the nucleocapsid sequence and its variant sequences. Such polypeptides may be useful in diagnosing and monitoring prostate cancer. In a particular aspect of the invention 'Providing a method for detecting a patient's prostate cancer, comprising (a) contacting a biological sample obtained from the patient with a binding reagent capable of binding one of the peptides; and (b) detecting the binding to the sample in the sample 忒Protein or polypeptide bound by an agent. In a preferred embodiment, the binding agent is an antibody, preferably a monoclonal antibody. In a related aspect, a method for monitoring the progress of prostate cancer in a patient is provided, including (a) Contacting a biological sample obtained from a patient with a binding reagent capable of binding one of the above-mentioned polypeptides; and (b) detecting the amount of protein or polypeptide bound to the binding reagent in the sample; (phantom repeat ( "And ii); and compare the amount of polypeptide detected in steps (b) and (c). In a related perspective, the present invention provides an antibody, preferably a monoclonal antibody, that binds to the polypeptide of the present invention, a diagnostic reagent containing such an antibody, and a method of using this antibody to inhibit the development of prostate cancer. The present invention further provides a method for detecting prostate cancer, which comprises (③) obtaining a biological sample from a patient; (b) subjecting the sample to the first and second oligonucleotides in a polymerase chain reaction Probe contact, at least one nucleotide probe pair (please read the precautions on the back first)

Printed by the Consumer Cooperatives of the Central Government Bureau of the Ministry of Economic Affairs of the Consumer Cooperatives 1228593 A7, '______________ B7 V. Description of the invention (3) The DNA molecule encoding one of the above peptides is specific, and (c) is detected in the sample. The amplified DNA sequence in the presence of the first and second probes. In a preferred embodiment, at least one oligonucleotide probe comprises a DNA molecule having at least about 10 adjacent nucleotides having a sequence selected from the group consisting of sequence recognition 2-3, 5-107, 109 Partial sequences of -11, 115-171, 173-175, 177 and 179-224. In a further aspect, the present invention provides a method for detecting prostate cancer in a patient, comprising (a) obtaining a biological sample from the patient; (b) causing the sample to be oligospecific to a DNA molecule encoding the polypeptide described above. The nucleic acid probe is contacted; and (c) detecting in the sample a DNA sequence that hybridizes to the oligonucleotide probe. Preferably, the oligonucleotide probe comprises a DNA molecule having at least about 15 adjacent nucleotides having a selected from the group consisting of sequence recognition 2-3, 5_ 107, 109-11, 115-171, 173 Partial sequence of -175, 177 and 179-224. In a related perspective, a diagnostic tool set including the oligonucleotide probes or primers above is provided. These and other aspects of the invention will obviously become a reference to the following detailed description and drawings. All reference materials disclosed in this article are incorporated herein for reference, as if each were individually incorporated. DESCRIPTION OF THE INVENTION As mentioned above, the present invention is generally directed to compositions and methods for immunodiagnostic and surveillance of prostate cancer. Compositions of the invention are usually polypeptides that include at least a portion of a prostate tumor protein. Also included in the invention are molecules (such as antibodies or fragments thereof) that bind to the polypeptides of the invention. In this -6 _ this paper size applies the Chinese National Standard (CNS) A4 specification (210X297 mm) (please read the precautions on the back before lUl this page)

1T 1228593 A7 B7 Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs ^ V. Description of the Invention (4) In the text, such molecules are called "binding reagents". More specifically, the polypeptide disclosed in the present invention includes at least a portion of a human prostate tumor protein, or a variant thereof, or a protein, wherein the prostate tumor protein includes a protein selected from the group consisting of sequence recognition 2-3, 5-107, 109-11, 115-171, 173 · 175, 177, and 179 «224 The nucleotide sequence of the nucleotide sequence mentioned in the DNA molecule encodes the amino acid sequence, the nucleotide sequence and its complements . When the term "polypeptide," is used herein, it includes amino acid chains of any length, including full-length protein cells, in which amino acid residues are linked by covalent peptide chains. Therefore, a polypeptide includes one of the above A part of the prostate protein, which may be entirely composed of the part, or the part may exist in a larger polypeptide, and contains an additional sequence. The additional sequence may be derived from a natural protein, or it may be a foreign protein. Derived, and such sequences may be immunoreactive and / or antigenic. When the "immunogenic portion" of a human prostate tumor protein is used herein, it is capable of being attacked by prostate cancer. The patient's body defies the immune response and therefore binds to the antibodies that appear in the serum obtained from patients with prostate cancer. Therefore, the immunogenic portion of the protein described herein can be confirmed in an antibody binding assay. This type of analysis is usually performed using any method known to those skilled in the art, for example, as described in Harolw and Lane, Antibodies: A Laboratory Manual, ColdSpring Harbor Laboratory, Cold Spring Harbor, NY, 1988 of. For example, the polypeptide can be immobilized on a solid support (as described below) and brought into contact with the patient's serum, allowing the antibody in the serum to bind to the immobilized polypeptide. Then you can remove the unbound serum and use, for example, * 7-(Please read the precautions on the back and then this page) • Packing · 11-line paper size applies Chinese National Standard (CNS) A4 specification (210X297 mm) 1228593 A7 B7 Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs. 5. Description of the invention (5) j 2 ^ ί-labeled protein A to detect the bound antibody. In addition, for the purpose of extracting Doxin from the serum or other fluids of patients with prostate cancer, the polypeptide can also be used to generate single and multiple strains of antibodies. The compositions and methods of the invention also include variants of the above polypeptides and DNA molecules. When a "variant" of a polypeptide is used herein, the difference from the mentioned polypeptide is only the retained substitution and / or modification of the polypeptide, so that the peptide (therapeutic, antigenic and / or immune) is retained. Characteristic. Polypeptide variants preferably show an identity of at least about 70/0 to the identified polypeptide, preferably at least about 90%, and most preferably at least about 950.0. About Prostate tumor polypeptides with immunoreactive properties can also be modified by modifying the amino acid sequence of one of the above polypeptides and evaluating the immunoreactivity of the modified polypeptide. About the diagnostic binding Reagents for prostate tumor polypeptides can be identified by assessing the ability of modified polypeptides to produce antibodies that detect the presence or absence of prostate cancer. Such modified sequences can use, for example, the representatives described herein Preparation and testing. When the term "reservative substitution," is used herein, one of the amino acids is replaced by another amino acid having similar properties such that Those skilled in the art of peptide chemistry will expect that the secondary structure and hydration properties of the peptide are largely unchanged. In general, amino acids in the following groups represent changes in retention: (1) ala, pro, gly, glu , Asp, gln, asn, ser, thr; (2) cys, ser, tyr, ihr; (3) val, ile, leu, met, ala, phe; (4) lys, arg, his ·, and (5 ) phe, tyi, trp, his. Variations can also, or contain other modifications, including deletions or additions -8- This paper size applies Chinese National Standard (CNS) A4 specifications (210X297 mm) (Please read first Note on the back page again} • Packing · -Printed by the Consumers 'Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs 1228593 A7 __ ___B7 V. Description of the invention (6 7 ~~ 一' 尔 ~ " 4 is the antigenic characteristic of the peptide, The secondary structure and hydration properties have the least impact = the base acid. For example, a polypeptide can be combined with a signal (or former) sequence at the N-terminus of a protein, which, in a common translation or post-translational manner, directs the protein's It can also make peptides and linkers or others easy to synthesize, purify or confirm Sequence binding (such as poly-His), or sequences that promote the binding of the polypeptide to a solid support. For example, the polypeptide can bind to the immunoglobulin F c region. A nucleotide "variant" is associated with the mentioned The nucleotide sequence differs in that it has one or more nucleotide deletion, substitution, or addition sequences. Such modifications can be easily introduced using standard mutation techniques, such as, for example, by Adeiman et al. (DNA, 2: 183 (1983) The oligonucleotide-position-specific mutation induced by oligonucleotide. The nuclear acid variant can also be a naturally occurring dual variant or a non-naturally occurring variant. The nucleotide | acid variant sequence preferably does not have at least about 70% identity to the mentioned sequence, more preferably at least about 80%, and most preferably at least about 90%. Such variant nucleotide sequences will usually hybridize to the mentioned nucleotide sequence under stringent conditions. When "stringent conditions" are used herein, it means hybridization in 6X SSC, 0.2% SDS overnight; then rinsed twice at 65 ° C with IX SSC, 0.1% SDS for 30 minutes, and Rinse twice at 65 ° C for 30 minutes with 0.2X SSC and 0.1% SDS. When a "polypeptide" is used herein, it also includes a combined or fused polypeptide. A "combined polypeptide" is a polypeptide consisting of at least one of the immunogenic portions described above, and one or more additional immunogenic prostate tumor-specific sequences, which can be linked to a single amino acid via a peptide bond Inside. Direct connection sequence -9- This paper size is applicable to Chinese National Standard (CNS) A4 (21 × 297mm) (Please read the precautions on the back before this page)

1228593 A7 B7 V. Description of the invention (7) column (that is, no amino acid is inserted), or can be connected through a linking sequence (such as Gly-Cys-CHy), which will not significantly reduce the constituent peptides (please Read the precautions on the reverse page: page) for immunogenic properties. The prostate tumor proteins of the present invention, and the DNA molecules encoding such proteins, can be isolated from the prostate tumor tissue by any of a variety of methods well known in the art. A DNA molecule corresponding to a gene (a part of which encodes the prostate tumor protein protein) of the present invention can be isolated from a prostate tumor cDNA library using a reduction technique as described in detail below. Examples of such DNA sequences are provided in sequence identification numbers 1-107, 109-111, 115_171, 173-175, 177, and 179_224. A portion of the DNA sequence thus obtained can be used, using techniques well known in the art (see, for example, Mullis et al., Cold Spring Harbor Symp. Quant. Biol., 51: 263, 1987; edited by Erlich, PCR Technology, Stockton Press, NY, 1989) to design oligonucleotide primers for the amplification of full-length DNA sequences in polymerase chain reaction (PCR). Once the DNA sequence encoding the polypeptide is obtained, standard mutagenesis techniques such as position-specific mutations directed by oligonucleotides directed by Adelman et al. (DNA, 2: 183, 1983) can be used to easily modify any The above modifications are imported. The Consumer Cooperative Association of the Central Standards Bureau of the Ministry of Economic Affairs can also synthesize or reconstitute the prostatic tumor peptides disclosed in this article. Synthetic polypeptides having less than about 100 amino acids, and usually less than about 50 amino acids, can be produced by techniques well known to those skilled in the art. For example, any commercially available solid-phase technology can be used, such as the Merrifield solid-phase synthesis method, in which an amino acid is continuously added to a growing amino acid chain (see, for example, Merrifield, J. Am. Chem. Soc · -10- This paper size applies to the national standard (CNS) A4 specification (210 × 297 mm) 1228593 A7 B7 Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs. 5. Description of the invention (8) 85: 2149 · 2146, 1963) to synthesize such polypeptides. Automated peptide synthesis equipment is available from suppliers such as Perkift Elmer / Applied BioSystems Division (Foster City, CA) and can be operated according to the manufacturer's instructions. In addition, any of the aforementioned polypeptides can also be produced recombinantly by inserting a DNa sequence encoding the polypeptide into a expression vector and expressing the protein in an appropriate host. Any of a variety of expression vectors known to those skilled in the art can be used to express the recombinant polypeptide of the present invention. Expression can be accomplished in any suitable host that has been transformed or transferred with an expression vector containing a DNA molecule encoding a recombinant polypeptide. Suitable host cells include prokaryotes, yeasts, and higher prion cells. Preferably, the host cells used are E. coli, yeast or mammalian cell lines, such as CHQ cells. A DNA sequence expressed in this manner may encode a naturally occurring polypeptide, a portion of a naturally occurring polypeptide, or other variants thereof. In general, regardless of the method of preparation, the polypeptides disclosed herein are generally prepared in pure form (that is, the polypeptide is determined to be homogeneous by amino acid composition and original sequence analysis). Preferably, the polypeptide is at least about 90% pure, more preferably at least about 95% pure, and most preferably at least about 99% pure. In certain specific embodiments, described in more detail below, the substantially pure polypeptides are incorporated into a pharmaceutical composition or vaccine used in the methods disclosed herein. In a related perspective, the present invention provides the first and second polypeptides of the present invention, or additionally the polypeptides of the present invention and known prostate antigens. 11-This paper applies Chinese National Standard (CNS) A4 Specifications (210X29? Mm) (Please read the precautions on the back before this page} Gutter 1228593 A7 B7 Printed by the Staff Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs 5. Description of the invention (9) Fusion protein, together with this type of fusion Protein variants. The fusion protein of the present invention may also contain a linker peptide between the first and second polypeptides. Using known recombinant DNA technology, the individual DNA sequences encoding the first and second polypeptides, Gathered into an appropriate expression vector to construct a DNA sequence encoding the fusion protein of the present invention. The 3 'end of the DNA sequence encoding the first polypeptide, with or without the use of a peptide linker, and the DNA encoding the second polypeptide The 5, ends of the sequence are ligated so that the code of the sequence allows the translation of the mRNA of two DNA sequences at the same time, becoming a single that retains the biological activity of the first and second polymorphisms Fusion protein. Peptide linker sequences can be used to separate the first and second polypeptides by a distance sufficient to ensure that each polypeptide folds into its secondary and tertiary structure. Utilizing standard techniques well known in the art Incorporate such peptide linker sequences into the fusion protein. Based on the following factors, the appropriate peptide linker can be selected: (1) its ability to adopt a flexible extension configuration; (2) its inability to adopt Secondary structures that interact with epitopes that are functional on the first and second polypeptides; and lack of water-repellent or charged residues that may react with functional epitopes on the polypeptide. Preferred peptide linkers The sequence includes Gly, Asn, and Ser residues. In the linker sequence, other near neutral amino acids such as Thr and Ala can also be used. It can be effectively used as the linker I amino acid sequence, including in Maratea Et al., Gene 4: 39_46, 1985; Murphy et al., Proc. Natl. Acad. Sci. USA 83: 8258_8262, 1986; those disclosed in U.S. Patent No. 4,935,233 and U.S. Patent No. 4,751,180. Linker sequences It can be from 1 to about 50 amino acids in length. When the first and second peptides have non-essential N-terminal amine groups-12- This paper size applies Chinese National Standard (CNS) A4 specifications (210X297 (Mm) (Please read the precautions on the back first, then the page) • Binding-Thread _ 1228593 A7 B7 V. Description of the invention (10 printed by the Staff Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs w 4 This area can be used to separate functions Functional sites and prevent interference between the two, without the need for peptide linkers. Know the ligated DNA sequence and operably link it to the appropriate translation element or translation element. The regulatory elements that cause DNA expression are only located at the 5 of the DNA sequence of the first polypeptide. Similarly, the stop code and green stop signal for ending translation appear only at 3, of the DNA sequence encoding the second polypeptide. The polypeptides and / or fusion proteins of the present invention can also be used to produce binding assays] like antibodies or fragments thereof which can detect metastatic human prostate swelling. The binding reagents of the present invention are generally known to those skilled in the art. Those methods include representative procedures described herein. Using the representative assays described herein, the binding reagent can identify patients with or without prostate cancer. In other words, antibodies or other binding agents that are elevated against prostate tumor proteins or appropriate portions thereof will produce an indication of the occurrence of primary or metastatic prostate cancer in at least about 20% of patients with the disease Signal, and will generate a negative signal indicative of the disease in at least about 90% of individuals and mounds with no primary or metastatic prostate cancer. An appropriate portion of this type of prostate tumor protein can be produced in substantially all patients (ie, at least about 80%, preferably at least about 90%) using full-length protein, which means that they do not have prostate cancer. Indicating the presence of primary or metastatic prostate cancer, and in general, those that are negative in all samples when tested using a full-length protein can refer to a binding agent that is not without prostate cancer. A representative analysis described below, such as a sandwich analysis of two antibodies, can usually be used to assess the binding of human prostate tumors to the metastases. -13- This paper is in accordance with Chinese National Standard (CNS) A4 (210X297 mm) )-^ --- ^ ----- batch clothes-(Please read the precautions on the back before ^^ this page) Order line 1228593 A7 B7 V. Description of the invention (1 · 1) Ability. The ability of a polypeptide and / or fusion protein prepared as described herein to generate antibodies capable of detecting primary or metastatic human prostate tumors' can often be achieved by raising one or more antibodies against the polypeptide. Assess (using, for example, the representative methods described herein) and determine the ability of such antibodies to detect such tumors in patients. The assay can be performed by analyzing the presence of a polypeptide bound to a produced antibody in a biological sample obtained from a patient with or without primary or metastatic prostate cancer. This type of test decantation can be performed using, for example, representative procedures described below. Through such procedures, polypeptides that produce antibodies capable of detecting at least 200/0 primary or metastatic prostate tumors are considered useful in the analysis of primary or metastatic human W prostate tumors. Antibodies specific to antibodies can be used alone or in combination to improve their sensitivity. Polypeptides and / or fusion proteins capable of detecting primary or metastatic human prostate tumors can also be used as markers to diagnose prostate cancer or monitor the progress of the disease in patients. In a specific embodiment, prostate cancer can be diagnosed in a patient by evaluating the amount of biological sample obtained from the patient with respect to one or more epithelial peptides relative to a predetermined cut-off threshold. When printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economics for use in this article, appropriate "biological samples, including blood, serum, urine, and / or prostate secretions. &Quot; Anything specific to the peptide (group) can be used Binding reagent to evaluate the content of one or more of the above-mentioned polypeptides. In the context of the present invention, a "selection agent ^ μ η reagent" is any preparation that binds to a polypeptide (such as a compound or a sprinter). “Combination” is used in this article to mean that there is a non-14 between two different molecules. The paper size is applicable to the Chinese National Standard (CNS) A4 specification (210X297 mm) 1228593 A7 B7. Printed by the Consumer Cooperative V. Description of the invention (12 Covalent connections (which are free (ie, in solution), or appear on the surface of cells or solid supports, respectively), so that `` complexes, Ingenious complexes can be free or immobilized on a supporting substance (either covalently or non-covalently). They are usually evaluated by determining the binding constants formed by the complexes. The binding capacity is estimated. The binding constant is the tritium obtained when the concentration of the complex is divided by the concentration of the constituents. Generally, in the context of the present invention, the so-called "combination of two compounds" is the complex formed. When the binding constant exceeds about 103 liters / mole. The binding constant can be determined using methods well known to those skilled in the art. Any preparation that meets the above requirements can be a binding reagent. For example, the binding agent can be Or ribosome without peptide component, RNA breakup or peptide. In a preferred embodiment, the binding partner is an antibody or a fragment thereof. Such antibodies can be multiple or single strains. In addition, the antibodies can be single chain , Chimeric, CDR_ colonized, or humanized. Antibodies can be prepared by the methods described herein 'or by other methods known to those skilled in the art.

There are various assays known to those skilled in the art to detect peptide labels using binding partners in a sample. See eg Harlow and Lane, Amibodies: A

Laboratory Manual, Cold Spring Harbor Laboratory, 1988 ° In a preferred embodiment, the analysis involves binding using a binding partner immobilized on a solid support and removal of the polypeptide from the residue of the sample. A second binding partner containing the reporter's base circle is then used to detect the bound peptide. A suitable second binding partner comprises an antibody that binds to the binding partner / polypeptide complex. In addition, competitive analysis can also be used, where the reporter group is used to label the polypeptide, and the binding partner and the sample are cultured together. This paper size applies the Chinese National Standard (CNS) A4 specification (210X297 mm) (please first Read the notes on the back page again} • Equipment · -ding, " '1228593 A7 Staff Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs, India and India —_-~~------------- V V. Description of the invention (13) It binds to the binding partner of solid I. The degree to which the component of the sample inhibits the binding of the labeled polypeptide binding partner represents the reactivity of the sample with the fixed binding partner. The solid support may be cooked Any agent known to this artist can attach antigens. For example, a solid support can be a test well on a microtiter plate, or nitrocellulose or other suitable membrane. In addition, the support can be small Beads or discs, such as glass, broken glass fibers, latex, or plastic materials such as polystyrene or polyvinyl chloride. The support may also be magnetic particles or fiber optic sensors, such as, for example, in US Patent No. 5,359,681 number Those described. Various techniques known to the artisan can be used to immobilize binding reagents on solid supports, which are described in detail in patents and scientific literature. In the context of the present invention, "fixed, a The word means non-covalent binding, such as adsorption, and covalent attachment (may be a direct bond between the antigen and the peptidyl group on the support, or it may be via a cross-linked preparation) Connection). It is better to attach to the well of the microtiter plate or fix it on the membrane. In this case, it can be done by contacting the binding reagent in a suitable buffer solution with the solid support for a suitable period of time. The contact time varies with temperature, but usually between about 1 hour and about 1 day. Generally speaking, plastic microtiter plates (such as polystyrene or polyvinylchloride) The amount of contact between the well and the binding reagent, ranging from about 10 nanograms to about 10 micrograms, preferably about 100 nanograms to about 1 microgram, is sufficient to fix an appropriate amount of the binding reagent. Valence attached to a solid support, which can usually be accomplished by first reacting the support with a reagent with two functions, the two functions -16,-This paper H applies the Chinese painting standard (CNS) A4 Specifications (210X297mm) '" ~ (Read the precautions on the back before reading this page) • Installation ·, 1T-line 1228593 A7 B7 V. Invention description (14) (Please read the precautions on the back before HI The reagent on the page will react with the support and functional groups on the binding reagent, such as «or amine groups. For example, benzene can be used to covalently attach the binding reagent to a support that is really coated with a suitable polymer. Or by condensation of an acid group on the support with an amine and active hydrogen on a binding partner (see, for example,

Pierce Itnmmioiechiioiogy Catalog and Handbook, 1991, in A12, A13). In certain embodiments, the analysis is a sandwich analysis of two antibodies. This analysis can be performed by first contacting an antibody that has been immobilized on a solid support, usually a microtiter plate well, with a sample to allow the polypeptide in the sample to bind to the immobilized antibody. The unbound sample is then removed from the immobilized peptide-antibody complex and a second antibody (containing reporter moieties) is added, which can bind to different positions on the peptide. The amount of a second antibody that continues to bind to the solid support is then determined using a method suitable for the particular reporter group. More specifically, once the antibody is fixed to a support as described above, the remaining protein binding sites on the support are blocked in a representative manner. The person skilled in the art knows any suitable blocking agent, such as bovine serum albumin or Tween 20 ™ (Sigma Chemical Co., St. Louis, MO). The immobilized antibody is then incubated with the sample and the polypeptide is allowed to bind to the antibody. Prior to incubation, the sample can be diluted with an appropriate diluent, such as phosphate-buffered saline (PBS). In general, an appropriate exposure time (ie, culture time) is a time sufficient to detect the presence of a polypeptide in a sample obtained from an individual with prostate cancer. Preferably, the contact time should be sufficient to complete, at least about what can be achieved when the equilibrium between the bound and unbound peptides is reached -iT- This paper size applies to China National Standard (CNS) A4 (210X297 mm) Ministry of Economic Affairs Printed by the Consumer Standards Cooperative of the Central Bureau of Standards 1228593 A7 -___ B7 '~ ^ ^ ----------- ~~ ---------------- ---____ V. Invention Explain the degree of (15) 7 5 / 〇l binding. Those skilled in the art will recognize that the time required to reach equilibrium 'can be easily determined by analyzing the extent to which bonding occurs during this period. An incubation time of about 30 minutes at a high temperature is usually sufficient. Unbound samples are then removed by rinsing the solid support with a suitable buffer solution, such as PBS 'containing 0.1% Tween 20 tm. A second antibody containing the reporter group can then be added to the solid support. Preferred reporter groups include enzymes (such as horseradish peroxidase), enzymes, cofactors, inhibitors, dyes, radionuclides, fluorenes, fluorescent groups, and biotin. The combination of antibody and reporter can be accomplished using standard methods known to the artist. The second antibody is then incubated with the immobilized antibody-polypeptide complex for a time sufficient to detect the bound polypeptide. The appropriate length of time can usually be determined by analyzing the degree of bonding that occurs during this time. However, the unbound second antibody was removed, and the reporter group was used to detect the bound second antibody. The method used to detect the reporter's base depends on the nature of the reporter's group. For radioactive groups, scintillation counting or autoradiography methods are usually appropriate. A spectroscopic method can be used to detect dyes, luminescent groups, and fluorescent groups. Biotin can be detected using avidin conjugated to different reporter groups (usually radioactive or fluorescein or enzymes). Enzyme reporter groups can usually be detected by adding an enzyme substrate (the system lasts for a sufficient period of time), followed by spectroscopic or other analysis of the reaction product. In order to determine the presence or absence of W column adenocarcinoma, the signal detected from the reporter group still bound to the solid support is usually in accordance with the pre-determined ____ _ 18- This paper scale applies Chinese national standards (CNS) A4 specifications (2l0X ^^^-——: --- ^-I .--- ^-I (Read the precautions on the back before buying)

1T line 1228593 A7 B7 V. Description of the invention (16 Please read back 5 I Matter and then m. Compare the truncated signal on this page. In a preferred embodiment, the truncation is straightforward. IS and, Seek from Wei, ¾ 'Sil S spring 5 ¾ I / ¾, the average 値 signal obtained when the sample is cultured together. Usually, a sample that produces a signal exceeding the pre-determined cutoff 値 three standard deviations Is considered positive for prostate cancer. In another preferred embodiment, the Receiver Operator Curve is used, according to Sacketi et al., Clinical Epidemiology: A Basic Science for Clinical Medicine, Little Brown and Co., 1985, page 106-7 to determine truncated pupae. In short, in this specific embodiment, the positive rate of pupae (that is, ) And the false positive rate (100% -specificity) of the paired chart to determine the truncation 値. In the chart, the truncation 最 closest to the upper left-side corner (that is, the 包围 that surrounds the largest area) is the most accurate truncation 値, Samples determined by this method to produce a signal higher than the truncated radon can be considered positive. In addition, the truncated radon can be shifted to the left along the graph to reduce the false positive rate, or to the right to Reduce false negative rate. Usually the sample that is determined by this method to produce a signal higher than the truncated radon is considered to be positive for prostate cancer. It is printed in the relevant specific examples by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs, The analysis is performed in a flow-through or stripping test format in which antibodies are immobilized on a membrane, such as nitrocellulose. In a flow-through test, when a sample passes through the membrane, the polypeptide in the sample is The immobilized antibody is bound. Then when the solution containing the second antibody flows through the membrane, the second labeled antibody binds to the antibody-polypeptide complex. The detection of the bound second antibody is then performed as described above. In the stripping test format, the end of the membrane that has been bound to the antibody is immersed in 19 paper sizes containing the sample, which is in accordance with the Chinese National Standard (CNS) A4 specification (21 × 297 mm). Ministry of Central Standards Bureau, Consumer Consumer Cooperatives, India 1228593 A7 ------ B7 " — —- _ V. Description of the invention (17) in solution. The sample moves along the membrane and passes the second antibody-containing Area and reach the area where the antibody is fixed. The concentration of the second antibody in the area where the antibody is immobilized indicates the presence of prostate cancer; see. Usually the concentration of the second antibody at this location produces a human-readable Graphics are like straight lines. The absence of such graphics represents a negative result. In general, the amount of antibody immobilized on the membrane is selected so that it produces a naked eye when the biological sample contains enough polypeptide to produce a positive signal in a sandwich analysis of two antibodies in the format discussed above. Recognizable graphics. Preferably, the amount of antibody immobilized on the membrane ranges from about 25 nanograms to about! Micrograms, more preferably from about 50¾ micrograms to about 500 micrograms. Such tests can usually be performed using a small number of biological samples. Of course, there are many other analytical protocols suitable for use with the antigen or antibody of the present invention. The above description is intended to be illustrative only. In another specific embodiment, the above polypeptide can be used as a marker for the progress of prostate cancer. In this specific example, the above-mentioned analysis for diagnosing prostate cancer can be performed over a period of time, and changes in the content of reactive polypeptides (classes) can be evaluated. For example, analysis can be performed every 24-72 hours over a period of 6 months to j years, and thereafter as needed. In general, prostate cancer is ongoing in those patients whose skin levels have been increased by binding reagents during this period. In contrast, when the content of the reactive polypeptide remains constant or decreases over time, prostate cancer does not progress. The antibodies used in the above methods can be prepared by any of a variety of techniques known to those skilled in the art. See, for example, Hariow and Lane, Antibodies: -20- This paper size is applicable to the Chinese National Standard (CNS) A4 specification (21〇χ297 mm) (Please read the precautions on the back before this page) • Installation-

1T 1228593 A7 B7, a consumer cooperative of employees of the Central Standards Bureau of the Ministry of Economic Affairs 5. Description of the invention (18) A Laboratory Manual, Cold Spring Harbor Laboratory, 1988 〇 In one such technology, immunization including antigenic peptides will be included in the beginning Originally injected into any of a variety of mammals (eg mice, rats, rabbits, sheep and goats). In this step, the polypeptide of the invention can be used as an immunogen without modification. In addition, especially for relatively short peptides, if the polypeptide is bound to a carrier protein, such as bovine serum albumin or keyhole limpet hemocyanin, a better immune response can be blamed. The injection of the immunogen into the animal host is best carried out according to a predetermined procedure, including one or more booster immunizations, and blood is collected from the animal on a regular basis. Polyclonal antibodies specific for the polypeptide can then be purified from such antisera by, for example, affinity chromatography using a polypeptide coupled to a suitable solid support. For example, Kohler and Milstein, Eur, J. Immimol. 6: 511-519, and modified techniques can be used to prepare monoclonal antibodies specific for the antigenic polypeptide of interest. Briefly, these methods involve the production of a permanent cell line capable of producing antibodies with the desired specificity (i.e., reactivity with the polypeptide of interest). Such cell lines can be produced, for example, from the spleen of an animal immunized as described above. The spleen cells are then immortalized by, for example, fusion with a fusion partner of a bone marrow cancer cell, most preferably a fusion partner that is synonymous with the animal to be immunized. Various fusion technologies are available. For example, non-ionic detergents can be used to mix spleen cells with bone marrow cancer cells for several minutes and then place them in a selective medium at a low gold level, which provides the growth of hybrid cells' but does not supply the growth of bone marrow cancer cells. The heavier selection technique uses HAT (hypoxanthine, aminopterin, thymic nucleus) selection. After sufficient time, usually about 1 to 2 weeks, hybridized colonies are obtained. Select a single • 21- This paper size is applicable to Chinese National Standard (CNS) A4 (210X297 mm) (Please read the precautions on the back and then the page) Packing--Order 1228593 Printed by the Consumer Standards Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs B7__V. Description of the invention (19) Colonies and testing of their binding activity to polypeptides. Fusion tumors with high reactivity and specificity are better. Individual strains can also be isolated from the supernatant of growing fusion tumor colonies. In addition, various techniques can be used to promote its production, such as injecting a fusion tumor cell line into the abdominal cavity of an appropriate vertebrate host, such as a mouse. Individual antibodies can then be harvested from ascites fluid or blood. By traditional methods Technology removes contaminants from antibodies, such as chromatography, gel filtration, precipitation, and extraction. The polypeptides of the invention can be used, for example, in purification procedures in affinity chromatography steps. The invention can also be used The monoclonal antibody is used as a therapeutic agent to reduce or eliminate prostate tumors. The antibody can be used alone (for example, to inhibit metastasis) or linked to one or more therapeutic agents For this purpose, suitable formulations include radionuclides, differentiation mediators, drugs, toxins and their derivatives. Preferred radionuclides include WY, i23I, 125I, i31I, i86lle, i88Re, plus At * 2i2Bi Preferred drugs include methotrexate and pyrimidine, and purine analogues. Preferred differentiation inducers include phorbol esters and butyric acid. Preferred toxins include ricin, chicken globin, Diphtheria toxin, Cholera toxin, gelonin, Pseudomonas exotoxin, Shiga-like toxin, and pokeweed antiviral protein. Therapeutic agents can also be used directly or indirectly (eg, via a linking group) with an appropriate (Such as covalent binding). When the preparation and the antibody have a substituent capable of reacting with each other, a direct reaction between the preparation and the antibody is possible. For example, a 'nucleophilic group, such as one There is an amine or sulfhydryl group on it, which may be able to react with a group containing -carbonyl group on another, such as -22- This paper size applies Chinese National Standard (CNS) A4 specification (210X297 mm) '(please first read Note again the back of this page) • installed ·

Line 1T 1228593 Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs A7 B7 V. Description of the invention (20) Alkali or tritium, or reacting with an alkyl group containing an excellent release group. Alternatively, it may be desired to bind to a therapeutic agent and an antibody via a linker group. The linker group may function as a spacer, keeping the antibody away from the agent ' ability to avoid interfering with binding. The linker group can also be used to increase the chemical reactivity of the substituents on the preparation or antibody, and therefore increase the coupling efficiency. Increasing the chemical reactivity can also promote the use of previously impossible preparations or the use of functional groups on the preparations . For those skilled in the art, it is obvious that bifunctional or multifunctional reagents can be used with the same or different functions (such as those described in the catalog of Pierce Chemical Co., Rockford, IL) as the linker base. Alas. For example, coupling can be performed via an amino group, a carboxyl group, a sulfhydryl group, or an oxidized carbohydrate residue. Numerous references describe such methods, such as U.S. Patent No. 4,671,958 to Rodwell et al. When the therapeutic agent is more potential when it does not contain the antibody portion of the immunoconjugate of the present invention, it may be desirable to use a linker group that can be cleaved during or at the time of absorption into the cell. Many different cleavable linker groups have been revealed. The intracellular mechanisms that release the agent from these linker groups include the reduction of disulfide bonds (e.g., Spitler, U.S. Patent No. 4,489,710), and the bonding to light instability by irradiation (e.g., Senter et al., U.S. Patent No. 4,625,014), amino acid side chains derived by hydrolysis (e.g. Kohn et al., U.S. Patent No. 4,638,045), hydrolyzed by serum complement regulation (e.g. Rodwell et al., U.S. Patent No. 4,671,958 No.), and acid-catalyzed hydrolysis (for example, Blattler et al., U.S. Patent No. 4,569,789). -23- This paper size is in accordance with Chinese National Standard (CNS) A4 specification (210X 297mm―) (Please read the precautions on the back before this page)

1. 1T printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs 1228593 A7 -------- B7 V. Description of the invention (21 — Yu: Can you want to couple more than one preparation to the antibody ^ in a specific In other cases, a plurality of molecules of a preparation are coupled to one antibody molecule. In a specific embodiment, more than one type of preparation may be coupled to p carcasses. Regardless of the specific embodiment, Various methods can be used to prepare immunoconjugates with more than one formulation. For example, more than one formulation can be directly coupled to the antibody molecule, or a linker that provides a plurality of < positions for K access can be used Alternatively, carriers can be used. Carriers can carry the formulation in a variety of ways, including covalent binding, either directly or via a linker group. Suitable carriers include proteins such as albumin (eg, Kato et al., U.S. Patent No. 4) No. 5,07,234), peptides and polysaccharides such as aminodextran (shih et al., U.S. Patent No. 4,699,784). Carriers can also be bound by non-covalent or by encapsulation To carry the preparation, like in micro Granule vacuoles (eg, US Patent Nos. 4,429,008 and 4,873,088) ° Specific carriers of radionuclide formulations, including radioactive small molecules and chelating compounds. For example, U.S. Patent No. Representative radioactive small molecule disclosed in No. 4,735,792 and its synthesis method. Radionuclide can be formed from those chelating compounds containing nitrogen and sulfur atoms which are donated atoms for binding with metal or metal oxide radionuclide. Chelate ^ For example, Davison et al., U.S. Patent No. 4,673,562, and representative synthetic compounds and methods of synthesis thereof. A variety of administration routes suitable for antibodies and immune conjugates can be used. Representative administration is intravenous, intramuscular , Subcutaneously, or reappear in the tumor's base. Obviously, the exact dose of antibody / immunoconjugate will be changed depending on the antibody used, the density of the antigen in the tumor, and the rate of antibody clearance. -24- This paper size applies China National Standard (CNS) A4 specification (210X297 mm) (Please read the precautions on the back before the page) • Installation.

1T 1228593 A7 _ B7 V. Description of the invention (22) The diagnostic reagent of the present invention may also include a DNA sequence encoding one or more of the above polypeptides, or one or more parts thereof. For example, in a polymerase chain reaction (PCR) based assay that expands prostate tumor-specific cDNA derived from a biological sample, at least two oligonucleotide primers can be used, of which at least one oligonucleotide primer is a The DNA molecules of the prostate tumor protein of the present invention are specific. The presence of amplified cDNA is then detected using techniques well known in the art, such as gel electrophoresis. Similarly, an oligonucleotide probe specific for a DNA molecule encoding a prostate tumor protein of the present invention can be used in a hybridization assay to detect the presence of the polypeptide of the present invention in a biological sample. Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs (please read the notes on the back before this page). When the term "oligonucleotide primers / probes specific for DNA molecules" is used in this article, it means The oligonucleotide sequence is at least about 80% identical to the problematic DNA molecule, preferably at least about 90% identical, and more preferably 95/0 identical. The oligonucleotide primers and / or probes used in the diagnostic method of the present invention preferably have at least about 10-40 nucleotides. In a preferred embodiment, the gadolinium fenamic acid primer includes at least about 10 adjacent nucleotides of the DNA molecule 'which have a sequence selected from sequence recognition 1-107, 173_175, 1-7, and 179-224. Sequence of numbers. Preferably, the oligonucleotide probe used in the diagnostic method of the present invention includes at least about 15 DNA molecules with adjacent nucleotides, and has a sequence recognition no ?, 10e > 1 ^ jj 15_ Sequences provided in Nos. 171, 173-175, 177, and 179-224. Techniques based on PCR and hybridization analysis are well known in the art (see, for example, Mixllis et al. In the same book; Ehriich in the same book). Therefore, primers or probes can be used to detect prostate tumors in raw samples. This paper size applies to Chinese National Standard (CNS) A4 specification (210X297 mm) ~ ---- 1228593 A7 B7 Central Ministry of Economic Affairs Printed by the Standards Bureau Consumer Cooperatives V. Invention Description (23) Sequences of the opposite sex, including blood, semen, prostate tissue, and / or prostate tumor tissue. For immunotherapy of prostate cancer, a polypeptide of the present invention including an immunogenic part of prostate tumor protein can also be used, wherein the polypeptide stimulates the patient's own immune response to prostate tumor cells. In a further aspect, the present invention provides the use of one or more DNA molecules (or encoding such polypeptides) having sequences provided in sequence recognition numbers 407, 109_111, 115-171, 173-175, 177, and 179_224. Dna) encoded immunoreactive polypeptides' methods of treating prostate cancer in patients by immunotherapy. "Patient" when used herein means any warm-blooded animal, preferably human. The patient may have a disease or may have no detectable disease. Therefore, the immunoreactive polypeptides described above can be used to treat prostate cancer or to inhibit the development of prostate cancer. The polypeptide can be administered before or after the surgical removal of the primary tumor and / or by the administration of radiation therapy and traditional chemotherapy drugs. In these perspectives, polypeptides are typically present in pharmaceutical compositions and / or vaccines. The pharmaceutical composition may include one or more polypeptides, each of which may contain one or more of the above-mentioned sequences (or variants thereof), and a physiologically acceptable carrier. Vaccines may include one or more of these polypeptides, and non-specific immune response promoters, such as adjuvants, biodegradable centrosomes (such as polylactic galactide) or microlipids (Incorporated into the peptide). Pharmaceutical compositions and vaccines can also include other antigenic determinants of prostate tumor antigens, incorporated into a combined polypeptide (ie, a single polypeptide containing multiple epitopes), or appear in separate polypeptides. -26- This paper size applies to Chinese National Standard (CNS) A4 (210X297mm) (Please read the precautions on the back before this page) • Loading ·

1T-line 1228593 A7 B7 V. Description of the invention (24) In addition, the pharmaceutical composition or vaccine may also contain DNA encoding one or more of the above-mentioned peptides, so that the polypeptide can be produced in situ. In such pharmaceutical compositions and vaccines, the DNA can be present in various delivery systems known to those skilled in the art, including nucleic acid expression systems, bacteria and virus expression systems. An appropriate nucleic acid expression system includes the necessary DNA sequences (such as appropriate promoter genes) to be expressed in a patient. Bacterial delivery systems involve the administration of bacteria (such as Bacillus-Calmette-Guerrin) that display prostate cell antigens on their cell surfaces. In a preferred embodiment, the DNA may be introduced using a viral expression system (such as vaccinia or other poxviruses, retroviruses or adenoviruses), which may involve non-pathogenic (defective) replicable viruses usage of. For example, in?丨 31 ^ 卜 11〇 ^ 1 and others? 8: 86-317-321, 1989; Flexner et al., Aim. NY Acad. Sci. 569: 86-103, 1989; Flexner et al., Vaccine 8: 17-21, 1990; U.S. Patent No. 4,603,112 Nos. 4,769,330 and 5,017,487; WO 89/0 1 973; U.S. Patent No. 4,777,127; German Patent No. 2,200,651; European Patent No. 0,345,242; WO 91/02805; Berkner, Biotechniques 6: 616-627, 1988; Rosenfeld et al., Science 252: 431-434, 1991; KqIIs et al., PNAS 91: 215-219, 1994; Kass-Eisler et al., PNAS 90: 11498-11502, 1993; Guzman et al., Circulation 88: 2838-2848, 1993; and Guzman et al. (: Res. 73: 1202-1207, 1993) discloses suitable systems. Techniques for incorporating DNA into such performance systems are known to those skilled in the art The DNA may also be "naked", as in, for example, published PCT applications WO 90/11092 and Ulmer et al., Science 259: 1745-1749, 1993, -27- This paper standard applies Chinese national standards ( CNS) A4 size (210X297mm) Please read the back first. Matters needing attention before m Printed by the Employees 'Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs 1228593 Printed by the Consumers' Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs A7 B7 V. Description of the Invention (25) Described in the review by Cohen, Science 259: 1691-1692, 1993. This can be done by applying m DN A is coated on biodegradable beads to increase the uptake of naked DNA 'to efficiently transport it into cells. The route and frequency of administration, and dosage, will vary from individual to individual' and may be similar Those currently used in immunotherapy for other diseases. Generally, pharmaceutical compositions can be administered by injection (e.g. intradermally, intramuscularly, intravenously or subcutaneously), intranasally (e.g. by inhalation) or orally And vaccines. Dosages between 1 and jo can be administered over a period of 3.24 weeks. It is better to 'administer 4 doses at 3-month intervals, after which supplemental administration can be given regularly. In addition, The Draft may also be appropriate for individual patients. The appropriate dose is a polypeptide or DNA that is sufficient to raise the immune response against prostate tumor cells (cellular and / or humoral) in the treated patient. the amount. A suitable immune response is at least 10-50% above the baseline (ie, untreated) content. The amount of polypeptide normally present in the dose (or produced in situ from DNA in the dose), ranging from about 1 picogram to about 100 milligrams per kilogram of host body weight, typically about 1Q picogram to about 1 mg, and preferably from about 100 picograms to about 1 picogram. The appropriate dose size will vary with the size of the patient, but will usually increase from about 0.01 to about 5 milliliters. When any suitable carrier known to those skilled in the art is used in the pharmaceutical composition of the present invention, the type of carrier will vary depending on the mode of administration. For parenteral administration, such as subcutaneous injection, the carrier preferably includes water, saline, alcohol, lipids, tincture, and / or buffered solution. For oral administration, you can use any of the above carriers, or solid carriers, such as mannose-28- This paper size applies Chinese National Standard (CNS) A4 specifications (210X297 mm) (Please read the precautions on the back first (This page)

1T 1228593 A7 B7 Printed by the Consumer Cooperatives of the Central Associated Bureau of the Ministry of Economic Affairs. 5. Description of the invention (26) Alcohol, lactose, powder, stearate, sodium saccharine, talc, cellulose, glucose, sucrose And / or magnesium carbonate. Biodegradable centrosomes (e.g., polylactic glycolide) can also be used as carriers for the pharmaceutical compositions of the present invention. Suitable biodegradable centrosomes are disclosed, for example, in U.S. Patent Nos. 4,897,268 and 5,075,109. In the vaccine of the present invention, any of various non-specific immune response promoters can be used. For example, an adjuvant may be included. Most adjuvants contain substances designed to protect the antigen from rapid metabolism, such as aluminum hydroxide or mineral oil, and non-specific immune response stimulants such as lipid A, Haemophilus pertussis ( Bordetella pertussis) or Mycobacterium tuberculosis. Such adjuvants are commercially available, such as FremuTs Incomplete Adjuvant and Complete Adjuvant (Difco Laboratories, Detrciit, MI), and Merck Adjuvant 65 ( Merck Adjuvant 65) (Merek and Company, Inc., Rahway, NJ). The polypeptides disclosed herein can also be used in vitro to treat prostate cancer. For example, commercially available cell isolation systems, such as CellPro Incorporated's (BotheU, WA) CEPRATE ™, can be used to isolate cells of the immune system, such as T cells, from the peripheral blood of afflicted patients (see US Patent No. 5,240,856; U.S. Patent No. 5,215,926; WO 9 " 16116 and WO 92/07243). The isolated cells are treated with one or more immunoreactive polypeptides contained in a delivery vehicle such as a centrosome to provide antigen-specific T cells. The population of tumor antigen-specific T cells is then expanded using standard techniques and the cells are administered back to the patient. -29-This paper size is in accordance with Chinese National Standard (CNS) A4 (210X297 mm) (Please read the precautions on the back before this page) • Binding · 1228593 Staff Consumption Co-operation Seal of the Central Bureau of Standards, Ministry of Economic Affairs System A7 _______ B7 V. Description of Invention (27) The following examples are provided for explanation, not for limitation. Examples Example 1 Isolation and characterization of prostate tumor polypeptides This example describes the isolation of prostate tumor polypeptides from a cDNA library of prostate tumors. The Superscript plastid system (BRL Life Technologies, Gaithersburg, MD 20897) for cDNA synthesis and plastid selection tools was used to construct a human prostate gland tumor cDNA expression library from prostate tumor poly A + RNA according to the manufacturer's draft. In particular, prostate tumor tissue was homogenized using polytron (Kinematica, Switzerland), and all RNA was extracted using Trizol reagent (BRL Life Technologies) according to the manufacturer's instructions. Poly-A + RNA was then purified using the Qiagenoligotex spin column mRNA purification tool set (Qiagen, Santa Clarita, CA 91355) according to the manufacturer's protocol. The Notl / oligo-dT18 primer was used to synthesize the first strand of cDNA. A double-stranded cDNA was synthesized, ligated to an EeoRI / BAXI conjugate (Invitrogen, Sab Diego, CA), and digested with Notl. For subsequent size fractionation, Chroma Spin-1000 columns (Clontech, Palo Alto, CA 94303) were used to connect the cDNA to the EcoRI / Notl position of pCDNA3.1 (Invitrogen), and the electrophoresis It was transformed into EleCtroMax E. Coli DH10B cells (BRL Life Technologies). Using the same procedure, a normal human pancreas cDNA expression library was prepared from a collection pool of six tissue samples (Clontech). By determining the number of independent colonies and the percentage of pure germline carrying the inserted sequence, the average inserted sequence ruler (please read the precautions on the back before this page).

、 1T -30- This paper size is applicable to China National Standards (CNs) A4 specification (210X297mm) 1228593 Employees' Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs Cooperative Printing India A7 B7 V. Description of invention (28) inch, and determined by sequence analysis The characteristics of the cDNA library. The prostate tumor bank contains 1.64 X 107 independent colonies, of which 70% of pure germlines have insertion sequences, and the average insertion sequence size is 1745 base pairs. The normal pancreas cDNA library contains 3.3 × 106 independent colonies, of which 69% of pure germlines contain insertions, and the average insertion size is 1120 base pairs. For these two performance libraries, sequence analysis revealed that most of the pure germlines had full-length cDNA sequences and were synthesized from mRNA with the lowest rRNA and mitochondrial DNA contamination. The above-mentioned prostate tumor and normal pancreas cDNA libraries were used to reduce the cDNA library, as described by Hara et al. (Blood, 84: 189-199, 1994), with some modifications. Specifically, an eDNA library of prostate tumor-specific reductions was generated as follows. A normal pancreas cDNA library (70 μg) was digested with EcoRI, NotI, and Sful, followed by a filling reaction with a DNA polymerase Klenow fragment. After phenol · chloroform extraction and ethanol precipitation, the DNA was dissolved in 100 microliters of H20, heat-denatured and 100 microliters (100 micrograms) of photoprobe biotin (Vector Laboratories, Burlingame, CA). According to the manufacturer's recommendation, the obtained mixture was irradiated with a 270 W solar lamp on ice for 20 minutes. Add additional light probe biotin (50 μl) and repeat the biotinylation reaction. After five extractions with butanol, the DNA was precipitated with ethanol and dissolved in 23 microliters of H20 to form the manipulator DNA. To form tracer DNA, digest 10 micrograms of prostate tumor cDNA library with BamHI and Xhol, extract by gas-like imitation, and pass it through a Chroma spin-400 column (Clontech). Followed by ethanol precipitation, dissolve the tracer DNA in 5 microliters * · 31 * I paper size applies Chinese National Standard (CNS) A4 specifications (210X297 mm 1 (Please read the precautions on the back before this page) • Installation · Order 1228593 A7 B7 printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs. 5. Description of the invention (29) H20. The tracker DNA and 15 microliters of manipulator DNA and 20 microliters of 2x hybridization buffer solution (1.5M NaCl / lOmM EDTA / 50mM HEPES pH 7.5 / 0 · 2% sodium lauryl sulfate) mixed, coated with mineral oil and fully heat denatured. Immediately move the sample to a 68 ° C water bath and incubate for 20 hours ( Long-term hybridization [LH]). The reaction mixture was then treated with avidin streptomycin, followed by phenol / chloroform extraction. This process was repeated three more times. The cut DNA was precipitated and diluted in 12 microliters of H20 , Mixed with 8 μl of manipulator DNA and 20 μl of 2x hybridization buffer solution and subjected to hybridization at 68 ° C for 2 hours (short-term hybridization [SH]). After removing the biotinylated double-stranded DNA, The cut cDNA was ligated to aerobicin-resistant pBCSK + (Stratagene, La Jolla , CA 92037), and transformed it into ElectroMax E. coli DH10B cells by electro-penetration to produce a prostate tumor-specific and reduced cDNA library (prostate reduction effect 1) 0 Analyze the reduced cDNA library, prepare plastid DNA from 100 independent pure germlines, randomly select from the reduced prostate tumor-specific expression library, and group by the size of the inserted sequence. By DNA sequencing, Perkin Elmer / Applied Biosystems Segmented Automatic Synthesizer Model 373A (Foster City, CA) was used to further characterize representative eDNA pure germlines. Six pure cDNA germlines are shown, hereinafter referred to as Fl-13, and Fl -12, Fl-16, H1-l, m-9, and H1-4, which are enriched with a reduced prostate-specific cDNA library. The identified 3 f of F1-12 is provided in sequence recognition numbers 2 and 3, respectively. And 5 f cDNA sequences, and the identified 3 'cDNA sequences of Fl-13, F16, Hl_1, Hl_9, and H1-4 are provided in Sequence Identification No. 1 and No. 7, respectively. -32- Applicable to this paper scale China National Standard (CNS) A4 specification (210X297 mm) (Please read the back first Notes on again) • The installation ·

1.1T printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs 1228593 A7 B7: ^ -------- ___________ V. Description of the invention (30) Use the EMBL and GenBank database (release 96) to isolate the eDNA of the pure germline that has been separated The sequences are compared with sequences known in gene banks. Determine four pure germline lines of prostate tumor cDNA, F1 -13, F1 -16, Η1 -1 and Η1 -4 encode the following previously confirmed proteins · Prostate Specific Antigen (ρ§A), Kallikrein of the human gland Releasing enzymes, human tumor expression enhancing genes, and mitochondrial cytochrome C oxidase subunit II. It was found that Η 1-9 is the same as the previously confirmed human automatic replication sequence. No significant homology was found for cDHA in F1-12. Subsequent research led to the isolation of the full-length cDNA sequence of F1-12. This sequence is provided in sequence identification number 107, and the corresponding predicted amino acid sequence is provided in sequence identification number 08. To colonize less abundant prostate tumor-specific genes, use the normal pancreas cDNA library to reduce the prostate tumor cDNA library as described above, and use the three most abundant genes in the previously reduced prostate tumor-specific cDNA library: the human gland Body kallikrein, prostate-specific antigen (PSA), and mitochondrial cytochrome C oxidase subunit II are used to reduce the cDNA library. Specifically, 'Add 1 microgram each of human gland kallikrein, psa, and mitochondrial cytochrome C oxidase subunit II cDNA in pCEVNA3.1 to the manipulator's DNA and reduce it as described above. A reduced second cDNA library was obtained, which is hereinafter referred to as "a reduced prostate tumor-specific cDNA library with a tracer". Twenty-two pure cDNA lines were isolated from a reduced prostate tumor-specific cDNa pool with tf longitudinal agents. 8-9, 10-11, 12-iS, 14-15, 16-17, 18.19, 20-21, 22-23, 24-25, 26-27, and 28--3 $ in sequence recognition -This standard is applicable to China National Standard (CNS) Α4 specification (210X297 mm) ~ '(Read the precautions on the back before reading this page)-Equipment, 1T 1228593 Printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs A7 B7 V. Description of the invention (31) — 29 The names of jTl 17, ji i3, "~" 1-24'0-58, (1_63, [1-4 and 1 ^ 1-14 The identified "and 5 'cDNA sequences are provided in sequence recognition Nos. 30-40 and named 仏 12,; 1] 6,] 1-2], {^ 48, [Bu55, [1- 2, 1 ^ 6, > ^ 1858, N1-1860, Nl-1861, N1-1864 pure lineages have been identified in columns 3, cD ^ A / f. These sequences are compared to those in gene banks as described above Comparing 'shows that three of the five most abundant DNA species (j_17, li_12 #! ^-1862; sequence recognition numbers 8_9, 10_11, and 12_13, respectively) have no significant homology. Among the next two most abundant species, one was found (Jl_ I 'sequence Chengbei No. 30) and Previously confirmed human lung surface-related proteins are the same 'and identified another (K1_48; sequence identification number 33) and Norwegian rat (R · norvegicus) mRNAi 2 _arylpropionyl_coA epimerase There is some homology. Of the π less abundant pure cDNA lines isolated from the reduced prostate tumor-specific cDNA library with tracer, four (Jl-16, Kl-55 'L1-6 and N1-1864; sequence identification numbers 31, 34, 36, and 40, respectively) are the same as the previously confirmed sequence, and two (j1-21 and N1-1860; sequence identification numbers 32 and 38, respectively) were found ) Showed some homology to non-human sequences, and two (L1_2 and N1-1861; sequence recognition 35 and 39 respectively) were found to show some homology to known human sequences. Polypeptides were found Jl-13, Jl-19, Ji-24, Jl-25, K1-58, Kί-63, L1-4, L 1-14 (respectively sequence recognition 14-15, 16-17, 20-21, 18 -19, 22-23, 24 · 25, 26_27 '28_29) have no significant homology. Subsequent research led to the full length of Jl-7, L1-12 and Nl-1862 (respectively sequence recognition 109-111). cDNA sequence Away. In the sequence identification No. 112-114 " · 34-This paper size applies the Chinese National Standard (CNS) A4 size (210X297 mm) (please read the precautions on the back before this page). _ Order · 1228593 Central Standard of the Ministry of Economic Affairs A7 B7 printed by the Bureau's Consumer Cooperatives 5. The corresponding predicted amino acid sequence is provided in the invention description (32). In a better experiment 'reduction of the prostate tumor cdnA pool by using normal prostate cDNA prepared from three normal prostate polyA + rnA heart collection pools' confirmed four additional pure germlines (prostate reduction effect 2). The determined cDNA sequences of these pure germlines are hereinafter referred to as ui-3064, Ul-3065, V1-3692, and 1A-3905, and are provided in sequence identification number 69 · 72, respectively. Comparison of the identified sequences with those in the gene bank showed no significant homology to Ul-3065. By using the normal pancreas cDNA library to reduce the tumor-specific prostate cDNA library with tracers, and further oxidize with PSA, J1-17, lung surface-related < protein, mitochondrial cDNA, cytochrome c Enzyme subunits π, Ni-1862, auto-replication sequence, L1-12, and tumor expression-promoting genes carry a tracer for a second tracer-reducing effect (prostate with tracer Reduction effect 2). Four additional pure germlines were isolated and named hereinafter Vl-3686, Rl_2330, 1B-3976 and V1-3679. The identified cDNA sequences of these pure germlines are provided in Sequence Identification Nos. 73-76, respectively. Comparison of these sequences with those in the gene bank showed no significant homology to V1_3686 and R1-2330. Further analysis of the above three prostate reduction actions (prostate reduction action 2, reduced prostate tumor-specific cDNa pool with tracer, and prostate reduction action with tracer 2), the results confirmed 16 additional Pure germline named 1G-4736, 1G-4738, 1G-4741, 1G-4744, lG_4734, lH-4774, lH-4781, lH-4785, lH-4787, m · 4796, 11-4810, 11- 4811, 1J-4876, IK-4884, and IK-4896. Respectively -35- This paper size applies Chinese National Standard (CNS) A4 specification (210X297 mm) (Please read the precautions on the back before buying this) $ 、 τ 1228593 A7 B7 Printed by the Consumers' Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs 2. Description of the invention (33) The identified cDNA sequences of these pure germlines are provided in sequence identification number 77_92. Comparing these sequences with those in the gene bank as described above, shows that for 1G-4741, 1G-4734, 11-4807, 1J4876, and 1K; 4896 (sequence recognition 79, 8 1, 87, 90, and 92) no Significant homology. Further analysis of the isolated pure germlines led to the identification of 10-4736, 10-4738, 10-4741, 1G4744, 1Η-4774, 1Η-4781, 1Η-4785, 1Η4787, lil · 4796, 11-4807, Extensive cDNA sequences of 1J-4876, IK-4884 and IK-4896 are provided in sequence recognition numbers 179-1S8 and 191-193, respectively, and the additional cDNA sequences of 11-4810 and 114811 are identified in sequence recognition Provided in Nos. 189 and 190. By reducing the normal prostate cDNA library with normal pancreatic cDNA, an additional reduction effect is performed (prostate reduction effect 3). This led to the identification of six additional pure lines, named 1G-4761, 1G-4762, 1H-4766, 1H-4770, 1H-4771, and 1H4772 (sequence identification number 93 · 98). Comparison of these sequences with those in the gene bank revealed no significant homology to 1G-4761 and 1Η-4771 (sequence recognition numbers 93 and 97, respectively). Further analysis of the isolated pure germline led the identification of the extensive cDNA sequences of 1G-4761 '1G-4762, 1H-4766 and 1H_4772, which were provided in sequence recognition numbers 194-196 and 199, respectively, and identified 1H-4770 and 1H -4771 additional part of the cDNA sequence, separately, J is provided in Sequence Identification Nos. 197 and 198. Using the normal pancreas cDNA library to reduce the prostate tumor cDNA library prepared from the poly A + RNA collection pool of three prostate cancer patients (Prostate Reduction Effect 4), eight pure germlines were identified and named 1D4297, 1 〇_ 4309, ID.1-4278, ID-4288, ID-4283, ID-4304, ID-4296, and ^ 36- ______ This paper size applies to China National Standard (CNS) A4 (210X297mm) (please first Read the notes on the back ^^ this page) • Loading ·

, 1T-line_ 1228593 A7 B7 V. Description of the invention (34) 11〇-4280 (serial identification number 99-107). As above, these sequences are compared with the base

Compare those in the bank. No significant homology was found for 1E > · 4283 * 1E > 4304 (sequence identification numbers 103 and 104, respectively). Further analysis of isolated pure germlines led the identification of a wide range of cDNa sequences for 1D_43〇9, 丄 4278, ⑴_4288 H 4283, ID-4304, 1D-4296, and 1D-4280, which were provided in sequence identification numbers 200-206 . The cDNA pure lines isolated in prostate reduction action 1 and prostate reduction action 2 as described above were subjected to solid-state PCR amplification, and microarray technology (Synteni, Palo Alto, CA) was used to determine their economics in the prostate. The Ministry of Central Standards Bureau staffs consumer cooperatives to print tumors, normal prostate, and mRNA expression in various other normal tissues. Briefly, PCR amplification products were spotted on a glass slide in an array format where each product occupied a separate position. The mRNA extracted from the tissue sample is tested, reverse transcribed, and a fluorescent-labeled ΝοΝΑ probe is produced. Probe microarrays using labeled cDNA probes, scan slides and measure fluorescence intensity. This intensity is correlated with hybridization intensity. Two new pure germlines (named P509S and P510S) were found to repeat-represent in prostate tumors and normal prostates, and in all other normal tissues tested (liver, pancreas, skin, bone marrow, brain, breast, adrenal glands) , Bladder, testes' salivary glands, large intestine, kidneys, ovaries, lungs, spine, skeletal muscle and colon). The identified cDNA sequences of P509S and P510S are provided in sequence identification numbers 223 and 224, respectively. Comparing these sequences with those in the gene bank, as shown above, shows some homology to previously identified ESTs. Example 2 -37- This paper size applies the Chinese National Standard (CNS) A4 specification (210X297 mm) 1228593 A7 B7 V. Description of the invention (35) Determine the tissue specificity of prostate tumor peptides using gene-specific primers in various RT-PCR was used in normal and tumor tissues to measure the mRNA expression levels of representative prostate tumor polypeptides Fl-16, Hl-1, J1-17, Ll-12, F1-12 and N1-1862. In short, Trizol reagent was used to extract the entire RNA from various normal and tumor tissues as described above. Using 1-2 μg of total RNA, complete the first strand synthesis using Superscript II Reverse Transcriptase (BRL Life Technologies) for 1 hour at 42 ° C. Gene-specific primers were then used to expand eDNA by PCR. To ensure the semi-quantitative nature of RT_PCR, Lu-actin was used as an internal control group for each test tissue. First, serial dilutions of the first strand of cDNAs were prepared and analyzed by RT-PCR using θ-actin-specific primers. Then select a dilution that will make the dots-actin template linearly enlarged and sensitive enough to reflect the difference in the number of original copies. Using these conditions, each reverse transcription response from each tissue was determined separately. Dots-actin content. DNA contamination is minimized by DNase treatment and by ensuring negative PCR results when using the first strand of cDNA prepared without the addition of reverse transcriptase. In four different types of tumors (prostate tumors from 2 patients' breast cancer, colon cancer, lung cancer from 3 patients) and 16 including prostate, colon, kidney, liver, lung, ovary, pancreas The expression level of mRNA was examined in different normal tissues of the skeletal muscle, skin, stomach, testes, bone marrow and brain. It was found that F1-16 had high expression in prostate tumor tissue, colon cancer and normal prostate, and low levels of epidermis in normal liver, skin and testicles, but it could not be detected in other tissues examined Performance. -38-This paper size is in accordance with Chinese National Standard (CNS) A4 (210X297mm) (Please read the notes on the back before page j. • Pei · Order · Printed by the Central Consumers Bureau of the Ministry of Economic Affairs Consumer Cooperatives 1228593 A7 B7 Economy Printed by the Consumer Standards Cooperative of the Ministry of Standards of the People's Republic of China. 5. Description of the Invention (3e) H1-1 was found to have high levels in prostate tumors, lung cancer, breast cancer, normal prostate, normal colon, and normal brain. It was found in normal lungs and pancreas. , Skeletal muscle, skin, small intestine, bone marrow have very low levels of expression, but not detected in other tissues tested. Η-17 and L1_12 obviously have particularly excessive expression in the prostate, these two genes in Prostate tumors and normal prostate have high levels of expression, but only low to undetectable in all other tissues examined. N1-1862 was found to be over-expressed in 60% of prostate tumors, and in normal colon and kidneys It can be detected. Therefore, the RT_pCR results indicate that Fl-16, Hl_1, Jl-17, Nb1862 and L1-12 are prostate-specific or have a significantly increased degree of expression in the prostate ^ A one-step RT-PCR study showed that F1-12 was overexpressed in 60% of prostate tumors and was detectable in normal kidneys, but was not detected in all other test groups. Similarly, it was shown that R1-2330 was present in Overexpression in 40% of prostate tumors' is detectable in normal kidneys and liver, but not detected in all other tissues tested. U1-3064 was found to be overexpressed in 60% of prostate tumors and also in breast cancer and It is manifested in colon cancer, but it is not detected in normal tissues. The ^^^ characteristics of disasters 1-2330, 111-3064, and 10-4279 show that these three antigens are excessive in prostate and / or prostate tumors. Performance. Northern analysis of four prostate tumors, two normal prostate samples, two BPH prostate and normal colon, kidney, liver, cerium, pancreas, skeletal muscle, brain, stomach, testes, small intestine and bone marrow, showing L 1-1 2 Overexpressed in prostate tumors and normal prostate, but not detectable in other normal test tissues. J b 17 was detected in two prostate tumors, but its -39- country Standard (CNS) A4 specification (210X297 mm) (Please read the precautions on the back before this page) • Binding. Thread 1228593 A7 B7 V. Invention Description (37 Printed by the Consumer Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs It was not detectable in the tissues. It was found that Νί-1862 was overexpressed in three prostate tumors, and I was present in normal prostate, colon, and kidney, but not in other test tissues. F1-12 was found in two prostate tumors Medium to high performance and not detected in all other tissues tested. The micro-array technology described above was used to determine the extent of representation of the representative antigens described herein in prostate tumors, breast cancer, and the following normal tissues: prostate, liver, pancreas, skin, bone marrow, brain, breast, adrenal gland, bladder L1-12 was found to be overexpressed in normal prostate and prostate tumors, and some manifestations were detected in normal skeletal muscle. Both η-12 and F1_12 were found to be over-expressed in prostate tumors and lower or undetectable in all other test tissues. N1-1862 was found to be expressed in high amounts in prostate tumors and normal prostates, and in low amounts in the normal large intestine and normal colon, 'while its performance was not detected in all other test tissues. R1-2330 was found to be over-expressed in prostate tumors and normal prostates, and low in all other tissues tested. 1D-4279 was found to be overexpressed in prostate tumors and normal prostates, and was present in low amounts in normal spines, while its performance was not detected in all other test tissues. Example 3 Hunting for a PCR-based reduction effect to isolate and characterize prostate tumor peptides. Use 10 other normal tissues of cdna (brain, heart, kidney, liver, lung, ovary, placenta, skeletal muscle, spleen, and thymus. ) Cut down the CDNA reduction library containing cDNA from normal prostate, and then accept it for purchase (please read the precautions on the back first, then this page). · · 11-line -40-1228593 A7 B7 V. Description of the invention (38)

Clontech's first round of PCR amplification. According to the manufacturer's draft, the library was subjected to a second round of PCR amplification. The resulting CDNA fragment was sub-selected into the vector pT7 Blue T-vector (Novagen, Madison, WI) and transformed into XL-1 BlUe MRF 'Stratagene. DNA was isolated from independent pure germlines and sequenced using the Perkin Elmer / Applied Biosystems Segmented Auto Sequencer Model 373A. Sequences of 59 positive pure germlines were determined. Comparing the DNA sequences of these pure germlines with those in the gene bank as described above shows that 25 of these pure germlines have no significant homology and are named hereinafter p5, p8, P9, P18, P20 , P30, P34, P36, P38, P39, P42, P49, P50, P53, P55, P60, P64, P65, P73, P75, P76, P79, and P84 〇 Printed on the staff consumer cooperative of the Central Standards Bureau of the Ministry of Economic Affairs (please Please read the notes on the reverse page before proceeding to this page) Sequence identification 41-45, 47-52, and 54-65 provide the identified cDNA sequences of these pure germlines, respectively. It was found that P29, P47, P68, P80 and P82 (sequence recognition numbers 46, 53 and 66-68) showed some degree of homology to the previously confirmed DNA sequence. To the knowledge of the present invention, none of these sequences have previously been shown to appear in the prostate. Further research using the PCR-based method described above resulted in the isolation of more than 180 additional pure germline lines, and found that 23 of them did not show significant homology to known sequences. The identified cDNA sequences of these pure germlines are provided in sequence recognition numbers 115-123, 127, 131, 137, 145, 147-151, 153, 156-158 and 160. Twenty-three pure germlines (sequence identifications 124-126 '128-130, 132-136, 138 · 144, 146' 152, 154, 155, and 159) were found to show some homology to previously identified ESTs. An additional 10 pure germlines (sequence identification 161-170) were found to show some degree of homology to known genes. Found a -41-This standard applies to China Standard (CNS) A4 specification (2 丨 〇'〆297 mm) '1228593 A7 B7 V. Description of the invention (39 additional pure germline named P703, which has five Junction variants. The identified ONA sequences of the variants named DE1, DE13, and DE14 are provided in sequence identification numbers 171, 175, and Γ77, respectively, and are provided in sequence identification numbers 172, 176, and 178, respectively. The corresponding predicted amino acid sequence. In sequence identification numbers 173 and 174, the DNA sequences of the conjugation variant named de2 and DE6 are provided, respectively. Hunting RT-PCR as described above, identifying representative pure germline In tumor tissue (prostate (n = 5), breast (n = 2), colon and lung), normal tissue (prostate (11 = 5), colon, kidney, liver, lung (n = 2), ovary (n2 2), skeletal muscle, skin, stomach, small intestine, and brain), and the extent of mRNA expression in activated and unactivated PBMc. Except where noted, performance is examined in a sample of each tissue type. Central Ministry of Economic Affairs Printed by the Bureau of Standards Consumer Cooperatives and all normal test groups In comparison, it was found that? 9 was highly expressed in normal prostate and prostate tumors and showed comparable performance except for normal colon tissue. Compared to all 12 normal test tissues, P20 was found to be It is highly expressed in normal prostate and prostate tumors. Compared with all normal tissues except the lung (2 of which are solid), p2O has moderately increased performance in breast cancer (n = 2), colon cancer, and lung cancer. Compared with normal tissues other than the lungs and stomach, pi8 was found to have enhanced expression in normal prostate and prostate tumors and breast cancer. Compared with most other normal tissues, pi8 was observed in normal spleen glands. The performance was moderately enhanced. However, elevated performance was seen in normal lungs and PBMCs. Some performance was also observed in prostate tumors (two out of five 7, breast cancer and one lung cancer sample, elevated P5 was observed Performance. Regarding P30, compared with six of 12 other normal test tissues -42- 1228593 A7 B7 V. Description of the invention (40) 'Similar performance was observed in normal prostate and prostate tumors In breast cancer, a lung cancer sample, and a colon cancer sample, and in normal PBMC, enhanced expression was seen. Compared with most normal tissues, P29 was found in prostate tumors (5 of 5 Over) in the normal prostate (5 out of 5). However, large numbers of P29 were observed in the normal colon and normal lung (2 out of 2). Comparing with all other normal test tissues By comparison, P80 was found to be overexpressed in prostate tumors (5 of 5) and normal prostate (5 of 5), and enhanced performance was also seen in colon cancer. Further research using the method described above resulted in the isolation of 16 additional pure lines. The identified DNA sequences of these pure germlines are provided in Sequence Identification Nos. 207-222. Further research using the methods described above resulted in the isolation of 16 additional pure germlines. The identified DNA sequences of these pure germlines are provided in Sequence Identification Nos. 207-222. Example 4 Polypeptide synthesis FMOC can be used on applied biological system 430A peptide synthesizer using HPTU (0-Benzamidine III-N, N, N ,, N, -tetramethylphosphonium hexafluorophosphate) activation Chemistry to synthesize peptides. The Gly-Cys-Gly sequence can be attached to the amine terminal of the peptide, providing a means of binding, binding to the immobilized surface, or labeling the peptide. The following cleavage mixtures can be used to cleave peptides from a solid support ... trifluoroacetic acid ... ethanedithiol ... phenylthiomethane ... water: phenol (40: 1: 2: 2: 3). After 2 hours of cutting, it can be used in cold methyl-tertiary-butyl-43 * This paper size applies Chinese National Standard (CNS) A4 specification (21 OX297 mm) (Please read the precautions on the back before this page) ), 1 'Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs 1228593 A7 B7 V. Description of the Invention (41) (Please read the precautions on the back and then precipitate the peptides in the ether on this page. The peptide pellets are then dissolved in Water containing 0.1% trifluoroacetic acid (TFA) and cold-dried before purification by CIS reverse-phase HPLC. 0% -60% acetonitrile (containing 0.1 % TFA) gradient to elute the peptides. The pure fractions are then freeze-dried, and the characteristics of the peptides can be determined by electrospray or other types of mass spectrometry and amino acid analysis. From the foregoing, Although the specific embodiments of the present invention have been described herein for the purpose of explanation, various modifications can be made without departing from the spirit and scope of the present invention. Sequence Listing (1) Common Information Subscriptions Audience: Xu, Jiangchun Dillin, Davin C. (ii) Title of Invention : Compounds for immunodiagnosing prostate cancer and how to use them (iii) Number of sequences: 224 (iv) Mailing address:

(A) To: SEED and BERRY LLP (B) Street: 6300 Columbia Center, 701 Fifth Avenue (C) City: Printed by the Consumers' Cooperative of the Central Standards Bureau, Seattle Department of Economics

(D) 卅: WA

(E) Country: USA (F) Zip code: 98104 (v) Computer-readable form: (A) Media type: floppy disk-44- This paper size applies to China National Standard (CNS) A4 specification (210X297 mm) 1228593 A7 B7 V. Description of Invention (42) (B) Computer: IBM PC compatible

(C) Operating system: PC-DOS / MS-DOS (D) Software: PatentInRelease # 1.0 # 1.30 version (vi) Current application information: (A) Application number: (B) Date of filing: February 23, 1998 (C) Classification: (viii) Lawyer / agent information: (A) Name: Maki, David J. (B) Registration number: 31,392 (C) Reference / case number: 210121.428C3 (ix) Telecommunications information: (A) Phone: (206) 6224900 (B) Pass it: (206) 682-6031 (2) Information of sequence identification number 1: ⑴ Sequence characteristics: (A) Length: 814 basis pairs (B) Type: Nucleic acid. Printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs (C)

(D) Topology: Straight line (ii) Molecular type: cDNA (xi) Sequence description: Sequence identification number 1: TTTTTTTTTT TTTTTCACAG TATAACAGCT CTTTATTTCT GTGAGTtCTA CTAGGAAATC ATCAAATCTG AGGGTTGTCT GGAGGACTTC AATACACCTC CCCCCATAOT GAATCAGCTT? Ccactggggccccccgggggtc

CTCCTTGGCT CACAGCCTTC TCTAGGCTTC CCAGTGCCTC CAGGACAGAG TGGGTTATGT _ -46 · This paper size applies to China National Standard (CNS) A4 (210X297 mm) 1228593 A7 B7 V. Description of the invention (43

TTTCAGCTCC CTTCATGOAO CTAGAGCGGC GCGCGCTTGO ATTCCACACA AHCTAACTCA TGCCAGCTGC TCTTCCGCTT ACTCCTCAAA AACAAAAGGG

ATCCTTGCTG AGTGTCCAGC CGCCACCGCG CGTAATCATG ACATACGAaC ChTTAATTGC ATTAATGAAT CTCGCTCACT GGNGGTATTA CANCAAAGGG

TGAOTGTCTG ACATGTCACT GTGGAGCTCC gtcataactg CGGAAGCMA GTTGCGCTCA GGGCCAACGC NANTCCTGCG CGGTTATCCN CNGAAACGTA

GTGCGTTGTG CTCCACTCTG AGCTTTTGTT TTTCCTGTGT aaotgtaaag CTGNCCGCTT NCGGGGAAAA CTCGGTCKTT: OTGGG

NAAATC AAAA

CCTCCAGCTT TCAGTGTTGGA CCCTTTAGTG GAAATTGTTA CCTGGGGTGC tccagtcngg gcggtttgcg CGGCTGCGGG GATACCCNGG

CTCCTCAGTG TCCACTAGTT AGGGTTAATT TCCGCTCACA CTAAtaAGTG AAAACTOTCG TTTTOGGGGC GAACGGTATG AAAAAANTTT 300 360 420 480 540 right 00 660 720 780 B14 2) Sequence identification number 2 lean machine (i) Sequence characteristics: (A) Length: 816 base pairs (B) : Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecular type: cDNA (xi) Sequence description: Sequence identification number 2 (please read the precautions on the back first? ^ This page • 装 _

ACAGAAATGT

TTCATGGCTG

CTAAAGTCTG

AAGTTTGGAG

ACAGATGCCT

AAGGAACGGG

CTGCTGTTAA

GCCGCCACCG

GGCGTAATCA

AACATACGAG

CATTAATTGC

TTANTGAATC

TCGCTCATTG

GGTNTNCCGG

TGGATGGTGG

TTGGAGCAAT

ATGAACTTCC

ATGTATTTGC

GTGTGACTCC

GCTCGTTTAT

ACACCCCAGC

CGGTGGAGCT

TGGTCATAGC

CCGGAAGATA

GTTGCGCTCA

NOCCACCCCC

ATCCTNGCNC

TTATCCCCAA

AGCACCTTTC agaaccccag

CAATCAGATG

AAAGAAGACG ggttctgact

CACCAGTGAG

CATCCCTTCT

CCAGCTTTTG

TGTTTCCTGT

AAGTGTTAAG

CTGCCCGCTT

CGGGAAAAGG

CCGGTCTTCG

ACNGGGGATA

TATACGACTT

TTCTACGAQG

AGCATGGATG

AAGGCAGAGT

TTTGAGOAGG

GAGCAGGACG

TTC ^ AAAGGG

TTCCCTTTAG

GTGAAATTGT

CCTGGGGTGC

TCCAGTCGGG

CGGTTGCNTT

GCTGCGGNGA

CCCNGA

ACAGGACAGC

TGCTGATCAA

ATTGGCCAGA

GGTGtCAAAT

TTGTTCATCA

TGAGCCCCCG

ATCCACTAGT

TGAGGGTTAA

TATCCGCTCA

CTAATGANTG

AAAACTGTCG

TTGGGCCTCT

ACGGTTCACT

AGATGGGGAA acgacttoga aatgaagaao

CTTTGACGGC

TGATCACAAC

CCCTGCACCT

TCTAGAAGCG ttgcgcgctt

CAATTCCCCC

AGCTAACTCN

TGCCA.CTGCN

TCCGCTTTCC

CCTCAAAGGC 60 120 1B0 240 300 360 420 480 540 ¢ 00 660 720 7S0 816 Printed nucleic acid single strand by the Consumer Cooperatives of the Central Economic and Technical Bureau of the Ministry of Economic Affairs (2) Sequence identification No. 3 information: ⑴ Sequence characteristics: (A) Length. · 773 base pairs (B) Type (C) Strand type -46- The paper is suitable for financial management "quasi (CNS) Ege (21Gx ^^ y 1228593 B7) V. Description of the invention (44) (D) Topology : linear (ii) mOLECULE tYPE: cDNA (xi) sequence Description: SEQ ID NO 3:. CTTTTGAAAG AAGGGATCGC TGGGGTGTTT AACAGCAGAG GTGCAGGGCG GGGGCTCACG 60 TCCTGCTCCT cactggtgat aaacgagccc cgttccttgt tgtgatcatg atgaacaacc 120 TCCTCAAAAG tCAGAACCGG AGTCACACAG GCATCTGTGC CGTCAAAGAT TTGACACCAC 180 TCTGCCTTCG TCTTCTTTGC AAATACATCT GCAAACTTCT TCTTCATTTC TGGCCAATCA 240 TCCATGCTCA TCTGATTGGG AAGTTCATCA GACTTTAGTC CANNTCCTTT GATCAGCAGC 300 TCGTAGAACT GGC-GTTCTAT TGCTCCAACA GCCATGAATT CCCCATCTGC TGTCCTGTAA 3 ^ 〇GTCGTATAGA AAGGTGCTCC GGCCGTCC CGCC CGCC CGCC CGCCCGGTAC CGCC CGCCCGGTAC G CGTTACCiUVC TTAATCGCCTT TGCAGCACAT CCCCCTTTCG 540 CCAGCTGGGC GTAATANCGA AAAGGCCCGC ACCGATCGCC CTTCCAACAG TTGCC3CACCT 600 GAATGGGNAA ATGGGACCCC CCTGTTACCG CGCATTNAAC CCCCGCNOGG TTTUGTTGTT € 60 ACCCCCACNT NNACCGCTTA CACTTTGCCA GCGCCTTANC GCCCGCTCCC TtTCNCCTTT 720 CTTCCCTTCC TTTCNCNCCH CTTTCCCCCG GGGTTTCCCJC CNTCAAACCC C: NA 773 (2) SEQ ID information number of 4: ⑴ SEQUENCE CHARACTERISTICS : (A) Length: 828 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecular type: cDNA (xi) Sequence description: Sequence identification number 4: (Please read the precautions on the back before this page)

, 1T line, Ministry of Economic Affairs Bureau of Standards staff consumer cooperative printed CCTCCTGAGT CCTACTGACC TGTGCTTTCT GGTGTOGAGT CCAGGGCTGC TAGGAAAAG < 3 60 AATGGC3CAGA CACAGGTGTA TGCCAATGTT TCTGAAATGG GTATAATTTC GTCCTCTCCT 120 TCGGAACACT GGCTGTCTCT GAAGACTTCT CGCTCAGTTT CAGTCAGOAC AGACACAAAG 180 ACGTGGGTGA CCATOTTGTT TGTGGGGTGC AGAGATGGGA GGGGTGGGGC CCACCCTGGA 240 AGAGTGGACA GTGACACAAG GTGGACACTC TCTACAGATC ACTGAGGATA AGCTGGAGCC 300 ACAATGCATG AGGCACACAC ACAGCAAGGA TGACNCTGTA AACA.TAGCCC ACGCTGTCCT 360 GNGGGCACTG GGAAGCCTAN ATNAGGCCGT GAGOANAAAG AAGGGGAGGA TCCACTAGTT 42〇CTANAOCGGC CGCCACCGCQ GTGGANCTCC ANCTTTTGTT CCCTTTAGTQ AGGGTTAATT 480 GCGCGCTTGG CNTAATCATG GTCATANCTN TTTCCTOTGT GAAATTOTTA TCCGCTCACA S40 ATTCCAGACA ACATACGANC CGGAAACATA AANTGTAAAC CTGGGGTGGC TAATGANTGA 600 CTAACTCACA TTAATTGCGT TGCGCTCACT GCCGGCTTTC CAATCNGGAA. ACGTGTCTTG 660 CCNCTTGCAT TiTATGAATCN GCCAACCCCC GGGGAAAAGC GTTTGCGTTT TGGGCGCTCT 720 TCCGCTTCCT CNCTCANTTA MTCCCTNCNC TCGGTCATTC CGGCTGCNGC AAACCGGTTC 78 0 ACCNCCTCCA AAGGGG GtAT TCCGGTTTCC CCNAATCCGG GGANANCC 828 -47- This paper size applies to China National Standard (CNS) A4 (210X297 mm), printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs 1228593 kl _________________ — B7 V. Description of the invention (45) (2) ) Information on sequence identification number 5: Sequence characteristics: (A) Length · 834 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecular type: cDNA (xi) sequence Description: SEQ ID NO 5: TTTTTTTTTT TTTTTACTGA TAGATGGAAT TTATTAAGCT TTTCACATGT GATAGCACAT 60 AOTTTTAATT GCATCCAAAG TACTAACAAA AA.CTCTAGCA ATCAAGAATG GCAGCATOTT 120 ATTTTATAAC AATCAACACC TGTGGCTTTT AAAATTTGGT TTTCATAAGA ΤΛΑΤΤΤΑΤΑΟ 150 T < 3AAGTAAAT CTAGCCATGC ΤΤΤΤΑΑΛΑΑΑ TGCTTTAGGT CACTCCAAGC TTGGGAGTTA 240 ACATTTGGCA TAAACAATAA TAAAACAATC ACAATTTAAT AAATAACAAA TACAACATTG 300 TAGGCCATAA TCATATACAG TATAAGGAAA AGGTOGTAGT GTTGAGTAAG CAGTTATTAG 3 ^ 0 AATAGAA.TAC CTTGGCCTCT AtGCAAATAT GTCTAGACAC TTTGATTCAC TCAGCCCTGA 420 CATTCAGTTT TCAAAGTAGG AGACAGGTTC TACAGTATCA TTTT ^ CAGXT TCCAACACAT 4BO TGAATiACAAG TMAAAATGA TGAGTTGATT TTTATTAATG CATTACATCG TCAAGAGTTA 540 TCACCAACCC CTCAGTTATA AAAAATTTTC AAGTTMATT AQTCATATAA CTTGGTGTOC 600 ΤΤΑΤΊΤΤΑΡΛ TTAGTGCTAA ATGGATTAAO TCiiAGACAAC AAtGGTCCCC TAATGTGATT 660 GATATTGGTC ATTTTTACCA GCTTCTAAAT GTNAACTTTC AGGCTTTTGA ACTGGAACAT 72 0 TGNATNAGAG TGTTCCANAG TTNCAACCTA CTGGAACATT ACAGTGTGCT TGATTCAAAA 780 TGTTATTTTG TTIU ^ AAATTA AATTTTAACC TGGTGGAAAA ATAATTTGAA ATNA 834 (2) Information on sequence identification No. 6 ... Sequence characteristics: (A) Length: 818 base pairs (B) Type: Nucleic acid (C) Strand type ... Single strand (D) Topology ... Straight line (ii) ) Molecule type: cDNA (xi) Sequence description: Sequence identification No. 6: (Please read the notes on the back before this page) _Binding · Binding-Thread L__ -48 The paper size of this paper applies the Chinese National Standard (CNS) A4 specification (210X297 mm) 1228593 A7 B7 V. Description of the invention (46 ')

TTTTTTTTTT

AACCACATCT

TGTAAAGTGA

GACGTGAAGT

AATGGTGAAG

TAAAATTGTA

GTGAGCTCAG

TTCTAGGGGA

AGQGGCTAGG

GGTAATAAAT

TTCGTATGTG

TTAKTANGGC

GTCATTANGA

GGAATNCNCC

TTTTTTTTTT

ACAAAATGCC

AATATTAGTT

CCGTGGAAGC

GGAGACTCGA

ATAAGCAGTG

GTGATTGATA

TTTAGCGGGG

CTGGAGTGGT

AGGATTATCC

CTTTCTCGTG

CTANTATGAA

NGGCTNAAAA

CGCCGGACNA

AAGACCCTCA

AGTA.TOAGGC

GGCGGATGAA

CTGTGGCTAC

AGTACTCTGA

CTTGAATtAT

CTCCTGATGC

TGATGCCTGT

AAAAGGCTCA

CGTATCGAAG

TTACATCGCG

GAACTTTTGG

GGCCCTGTTA

NTGNATCGCT

TCAATAQATG GGGGGCTTCG GCAGATAGTG AAAAAATGTT GGCTTOTAGG TTGGTTTCGG GAGTAATACG; CGAG kTCCT GCCTTTTTGG CCATCATTGO ANTGGAATTA ngggtctggg

ATTCTTAA

GAGACATACA

AAGCCAAAGT

AGGAAAGTTG

GAGCCGTAGA

AGGGTAAAAT

TTGTTTTCTA

GATGTGTTTA

TGCCGTCCTA

GCGAAGAAAA

ACAGGTGGTG

TATATGGTTA

AATCAATNGC

CTNGGTTTTA

GAAATAGTCA

GATGTTTGGA agccaataat

TGCCGTCGGA

AGAGACCCAG

TTAGACTATG

GGAGTGGGAC

GTTGGOGGGT

AAACTTCTGA

TGTGGTGGCC

GtGTGTTGGG ttggccggaa

CCCNACCCAT (2) Sequence identification number 7: ⑴Sequence features: (A) Length · S17 base pairs TGGGGCC GAAAAAl

60 120 160 240 300 360 420 4S0 540 600 ¢ 60 720 780 81S (Please read the notes on the back before this page) Equipment-Single-Strand Nucleic Acid Single-line Straight Line Ministry of Economic Affairs Central Standards Bureau Employees Consumer Cooperatives Printing Traditional Chinese (B) Type (C) Stock Type (D) Topology:

(ii) Molecular type: cDNA (xi) Sequence description: Sequence identification number 7

TTTTTTTTTT CGCGCCCTAT GGTTTGCTCC AAGTGGTTTG GTCATGAGTG GTACTACTCG GAAGTATGTA ATTGGTGGCG AGGATNCCTT TCAAACNGTC GAATNTTNNG CNTTATCNTN ACNATTGGAT CTTNANTGAN

T? * 1 * T? Ί * Ί * ίχττχι TTCAAAGATT ACAGATTTCA GTTTAGACGT CAAGACGTCT ATTGTCAACG GGAATTGAAG AATTGATTTG NGGGATGGGA TCTANTTCCT CAAAAGGGCT AAAGGTNATA NGCCCANTTC GGTTATTCNG

TGGCTCTAGA TTTAGGGQAA GAGCATTGAC CCGGGAATTG TGTGATGTAA TCAAGGAGTG attaatccgg ATGGTAAGGG AGGCNATNAA gaaacgtgtg TACAGGACTA accnctccta CANAAAKGGC CCCTNGCNTT

GGGGGTAdAG TTAATTCTAG CGTAGTATAG CATCTOTTTT TTATTATACN GCAGGTCGCG CGTAGTCGC5T GAGGGATCGT GCACTANGGA aaatgttaat gaaaccaaat TNATCCCACC CNCCCCCCGG ATCANCC: 2) Information on sequence identification number 8: ⑴Sequence features:, (A) type pairs · 799

GGGGtGCTAT GACGATGGGT CCCCGGTCGT TAAGCCTAAT AATGGGOGCT TGGTTCTAGG GTTCTCCTAG TGAACTCGTC TNAATGGCGG AANAATTAAN ANGAAMNTA CAATNGNATT TGNANNCCNC

AGGGTAAATA ATGAAACTGT GTAGCOGTGA GTGGGGACAO tcaatcggga aataatgggg GTTCAATACC TGTTATGTAA GGANGATATT TTTNGTTATT atnntaangg CCGCACNCNN CTTTTGTTCC ¢ 0 120 180 240 300 360 420 460 S40 600 660 720 7 Θ0 017-49 standard A7 paper size (China's paper size) V. Description of the invention (47) (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecular type: cDNA (xi) Sequence description: Sequence identification number 8: CATTTCCGGO TTTACTTTCT AAGOAAAGCC GAGCGGAAGC TGCTAACQTG GGAATCGGTG 60 CATAAGGAGA ACTTTCTGCT GOCACQCGCT AGC3GACAAGC GGQAGAGCGA CTCCGAGCGT 120 CTGAAGCGOA CGTCCCAGAA GGTGaACTTG GCACTGAAAC AGCTGGGACA CATCCGCGAG 1Θ0 TACGAACAGC GCCTGAAAGT GCTGGAGCGG GAGGTCCAGC AGTGTAGCCG CGTCCTGGGG 240 TGGOTGGCCG ANC3CCTGANG CGCTCTGCCT TGCTGCCCCC ANGTGGGGCO CCACCCCCTG 300 ACXITGCGTGG GTGCAAACAC TGAGCCCTGC TOGGGGACTT CAAGGANAAC CCCCACANGG 350 GGATTTXGCT CCTANANTAA GQCTCATCTG GGCCTGGGCG CCCCCACCTG GTTGGCCTTO 420 TCTTTGANGT GAGCCCCAtG TCCATCTGGG CCACTGTCNG GACCACCTTT NGGGAGXGTT 480 CTCCTTACAA. CCACANNATG CCCGGCTCCT CCCGGAAACC ANTCCCANCC TGNGAAGOAT 540 CAAGWCCTGN ATGCACTNNT NCTANAACCG GCCNCCNCCG CNOTGGAACC CNCCTTNTGT 600 TCCTTTTCNT TtlAGGGTTAA TliNCGCCTTG GCCTTNCCAN NOTCCTNCNC NTTTTCCNNT 660 GTTNAAATTG TTANGCNGGC NCCNNTCCCN CNNCNNCNAN CCCGACCCNN ANNTTNNANN 720 NGCTGGGGGT NCCNNCNGAT TGACCCNNCC NGCCTNTANT TGCNTTNGGG NNCNNTOCCC 780 CTTTCCCTCT NGGGANNCG 799 (Please re-read the notes on the back of this page) • Loading ·

(2) Information of sequence identification number 9: (i) Sequence characteristics: (A) Length: 801 base pairs "B" Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecular TypeΞ cDNA

、 1T Printed (xi) sequence description by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs · Serial Identification No. 9: ACGCCTTGAT CCTCCCAGGC TGGGACTGGT TCTGGGAGGA GCCGGGCATG CTGTGGCTCT 60 TAANGATGAG ACTGCCAAAG GTGGTCCTGGTCCTCCAGGACACAAGAGCAAGAGCA GCTCAGTGTT TGGACCCANG 240 CAGGTCATGG GGTTGTNGNC CAACTGC3GGG CCNCAACGCA AAANGGCKCA GGGCCTCNGN 300 CACCCATCCC ANGACX3CGGG TACACTNCTG GACCTCCCNC TCCACCACTT TCATGCGCTG 3 $. TTCNTACCCG CGNATNTGTC CCANCTGTTT CNGTGCCNAC TCCANCTTCT NGGACGTGCG 420 CTACATACGC CCGGANTCNC NCTCCGGCTT TGTCCCTATC CAGGTNCCAN CAACAAATTT 460 CNCCNTANTO CACCNATTCC CACNTTTNNC AGNTTTCCNC NKCGNGCTTC CTT. GGTTGANCGC CGGAAAATNC CCCAAAGGGG GGGGGCCNGG TACCGAAGTN CCCCCTNATA 600 GCTGAANTCC CCATNACCNN GNCTCN ^ TGG ANCCNTCCNT TTTAANNACN TTCTNi \ ACTT 660 GGGAANANOC CTCGNCCNTN CCCCCNTTAA TCCCNCCTTG CNAN013NCNT CCCCCNNTCC 720 NCCCNNWTNG GCNTNTNANN CNAAAAAGGC CCNNNANCAA TCTCGTNNCN CCTCANTTCO 780 CCANCCCTCG AAATCGGCCN CB〇l -50- This paper scales applicable Chinese National Standard (CNS) A4 specifications (210X297 male thin) 1228593 ΚΊ B7 48 V. Description of the invention (、 Consumption cooperation with employees of the Central Bureau of the Ministry of Economic Affairs of the People's Republic of China) Printing (2) Serial identification number 10 information: ⑴Sequence characteristics ·· (A) Length: 789 Base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecular type: cDNA (xi) Sequence description ·· Sequence identification number 10

CAGTGTATNT ACAGTGTGGC AGATCCTGCC AATACCGAGG CAGGCCCTAA TGCTCCCACC TGGTGGGTGA CCATCCTGGA TGTCCAGCTC CCCATTTACT TTAAAAAATT TCCTGTTAAC GTQGCTCTCT GGNGTTCCC

GGCCAGTGTG GGAGCTTTCC CGTGGTGACA GCTTCAGCCG CTACACACTG GCCTCCCTCT GGACAGTGGA OOTGCTAGCA GCCTGGAGCT CCCTTCCCTA

TCCACCCGCG GCCCACCGAN TAGTGCTTCC AGCCAGTCTG

CTCTGCGGGQ GCCAjGGGTGG TOCTGTCCCA TCACTGCCTA

TTGCTACACA GOTANTATTT CCAGCAACAT TGGGGGTGGA cccatgqggc tgcgggcttg GCTGCCACCT GTTGCTOGGT

CTGTGGCTC3C CGGTGCCACA CCCTCACCGG GTTCACCTTC accaccggga gaagcaggtg gtoaggacag cctgatgacc ATGGACACGT GGGTGCTGGA cgtctgcctg tgatgtctcc TTCCGGGCCG GGGCATCTGC NGTGGCCCCA TCCCTGTTTA TATGQTGTCT GCCGCAGGCC GACAAGAACG ANTTGGCCAA AGGCCTGCCT OACTGGGTCC GCCGCCAATT TCTOTTGCTG GAAQTGCNTA CNGCNCANCT TGCCTGTCCC TCAGCCCTGC TTCCTGCCCA AGCTTCCTGC GGCAGTGGCC GTACGTGTGG CTGGACCTCQ TGGGCTCCAT TGGGTCTGGT ATACTCAGCO AACTCCCCGC CCAAANTNAT ngggggctng 60 12 0 180 240 300 360 420 4 reads 0 540 600 6 € Q 720 780 75 points (please read the notes on the back first and then this page) • equipment. (2) Information of sequence identification number 11: (i) Sequence characteristics: (A) Length: 772 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology · Straight line (ii) Molecular type: cDNA (xi) Sequence description · Sequence identification number 11: CCCACCCTAC ccaaatatta gacaccaaca cagaaaagct agcaatggat tccottgtac tttgttaaat aaataagtta aatatttaaa tgcctgtgtc tctgtgatgg caacagaagg ACCAACAGGC CACATCCTGA TAAAAGC3TAA GAGGGGGOTG GATCAGCAAA AAGACAGTGC tgtgggctga. goggacctgg ttcttgtgtg ttgcccgtca ggactcttcg cctacaaata actttcatat gttcaaatcc catggaggao tgtttcatcc tagaaactcc catgcaagag CTACATTAAA COAAGCTGCA GGTTAAGGGG CTTANAGATO GGAAAdCAGG tgactgagtt 120 180 240 300 360 lines--51-This paper applies the Chinese National Standard (Big 7 7285) A5 Specification (CN7210 5) A4

TATTCAGCTC

CTGAGCCTOG CTccCTGTivr aactggggaa gcacagggtg

ACCCGGCCAC GGCCCNCCAC ccaaaaaccc

GTAATCCACC aagtccagag aaaagaaaag

GCAGCAAAAA

CCCNANGGGG

CCCNAATNTT

TTCTGTAGGT

TGCAGAGTCC

TGAAACCCCC

GACGCCCCAN

AACCACTTTA

GTTAACAGGA gctgcgaaat

GTGTCTCAAC

CCGCATTCCA

TTGGAAGGNG

CCCCCAGCTG

CTTTGGCACA

ANCNGGGNAA

TTTTCCTCCC

TAGGAGGCTA

GTGCATGGAA

TCCAGTCAGG

TGCANCTACG aacaaaaact

CNTGGAACCC

CTAAATTNTT

GCTGTTAACC

CCCTTCTGGC

CAGCCCTAMA

CACCTCAACA

NGGGGGGGCA

AATTNAGGCA

TC 420 4B0 S40 600 660 7 ^ 0 772 (2) Information of sequence identification number 12: ⑴ Sequence characteristics: (A) Length: 751 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand

(D) Topology: straight line (ii) Molecular type: cDNA (xi) Sequence description: Sequence identification number 12:

GCGCCAATTC AGCTGATTGA TTGQGTGTC3T AAGTANGGTG ATGGTGGTGT GGCACTACCA AGCAGCTGCN ACACTTGCTC CNCCGGCTGC AQTGGCCCNA CCAACAGQGQ TNATNAACNT AANGAACTCN

CAGCTCCCAC AGCAACCCTC TGQTOACGTT AGTCCTCAAA TCCACACTTG GCAACGTCAG ACCTCAOC TCAGTCTT. GATGAAGAAA AAAATCTTCA CTGCCCCACN GAACCCTGCN GAAGNCCCCA: AA ΓΑΝACCACCC TACTTT1

: CACG: TTGG GTCATTGCAA ATCCGTATAG AQTGAAGTCT GGAAGTGCTC tgaaoatgan CACCA.TANCA TNACGCCNCG AAAAGGATGC CNCNNAACGA TNGTGGCTCC CNGGANANNG

GTGACTGCAT TAGTTCGGAT TCGTGAGCCT TTTGGTTGGT CAGAATGOGG gaaaggcact TTGGTGAAGC CACAGCACTT TCCTGQGAAC CATAATCTTT AGCCATTGTG GTQTACACCA GAGGANOATG AAGAAGAACNG GCCCNTGAAA ACCAANANCA TTGACAAACT CCTGTGCATAG

GTCATACAAA GCAGGTTTCA GTTCTCTTTG GACCCCTTTC CTTGATGGCA AGGCX3ACCAC TCNCGAGGGC AAGACCACNA TGGGANCCAC ATGCCCACTG TOCNTGGTCX CTTCTNAANN ¢ 0 120 180 240 300 360 420 480 540 600 650 720 751 .Sequence of printed information for employees' cooperation cooperation in the Central Standards Bureau, Ministry of Economic Affairs, printed sequence number 13: Features: (A) Length: 729 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight-52 · This paper size applies to Chinese National Standard (CNS) A4 specifications (210X 297 mm) 1228593 A7 B7 V. Description of the invention (50 (ii) Molecular type: cDNA (xi) Sequence description: Sequence identification number 13:

GAGCCAGGCG TGTGGANCCT ACCATGCAGT CTGTGTGGTG CTGAAGATCT CTCATCGCAG ACTGAGAGCA GAGGTTGCAA TCCTGGTAAT GTTGGAACAC GAAGANTCAC ACGTCCCCAA ATTNAAGGG

TCCCTCTGCC TGCGCACTCA GTGGCAACAC CAGCAGTNCC CTCTTTCAGA ACTCANTGCC GCTTCAGCTT CATTAAGACC ATGATGATCC CAGCCCTGTT GGCAGTGGGC ATCTGGGTGT TCGGGCCACT GTCGTCCAGT GCCATGCAGT CCGGCGTTGT GGTCTTAGCT GTAGGTTTCC AGTGTGCCCT COTGACGTTC TTCTTCATCC TGCTGTGGTC GCCTTGGTGT ACACCACAA.T JAAAAGAT TATGGGTTCC JCTCAAGT GCTGTGGCTT CTACTTCAAA GAAAANAGTG CCTTTCCCCC CACAGCCAAT TCAAAACCTG CACCCAACCC

GCCTGCjfATC AANi CACCATGAAA GGGC

CCGGGAGCTG AAGANCCCTG TCTXCAATTT CAATCGATGG TTGTCAACGT TGGGCtGCTA TCCTCCTCAT GGCTGAGCAC CAGGAANACT CNNCCAAGTA ATTTCTGTTG AAANGOGTCC

TTTTGTCCTT AACAGGAGCC GCTCATCTTT GGCATCGTTT GGGCTACTTC TGGTGCTAAG CTTCATTGCT TTCCTGACGT TCACTCAAGT TACGGATTTT CAATTGACAA CCAACCANAA 60 120 180 240 300 360 420 480 540 600 660 720 729 (2) Sequence identification number 14: (Number of sequences: AA B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecular type: cDNA (xi) Sequence description: Sequence identification number 14 (please read the precautions on the back before this page) '

1T * Printed by the Consumer Cooperatives of the Central Bureau of the Ministry of Economic Affairs

TGCTCTTCCT TGTTCGCTGA GGCAGGTCCA CCACTCGTGT TCACACTCCA CANGTGCCAG TGANCCCCAN ATCTTCTTCC GCANATCTGC CAANCTTGTT CTGTNNANCT GGGACAAGGT CNCNCTCCTA CACAACCCTN

CAAAGTTCTT CTl'GTTGCCA AGGGGTTGTA GTACCAGCGC CGCAGTGCCC TTTGTCACTG ATTTTTCACA GGCAGCCTCG GGAAACTGTC NATGCAGCAO AGCACACTGG ATGGCGCCTT ANCTGCCTCT CAAANGCCCC CGAAAGGTAG TTNTTCTTGT TCCGNGGGGQ TCNTANTACC TGGATNCGAA. GCNATAATCT TTAGNCCNTG GTCCTCNTGG AANTNGCCNT CCTTTNAATT CCCCAGAAAN NCCGTGTTCC CCCCACCCAG CGGTTCNGNT

TAACAACCAG CATAGGTAAA GCGGGCGCAG iATGCTCT CCTTGCAGAO TCCTGTGTCT ^ AAATGGA TGCGCTGGAG CTCGTCAAAG tccgacgcgt cggggcagtt gggggtgtct CCATTGCTGC AGCGGAACTG GGTGGGCTGA TCCATQNNAW GGOGCCTGITG GGAAAQTCCC ACCTTGCACA CCGCGACAGG CTAGAATGGA TOCCCAANCC ANCCCCNTAA ACAAACTCTT ANCGTGGGAA AAGAACCCCA GGCNQCGAAC NCTNTTCTGC TTGGTGGACA GCACCANTNA OTTONNCTTG AACCTAATCN GCNNTCAACT CCCNANCNTM CCCCCTGGTT TGGGQTTTTN CCGCCAACTA GCGGCCNfAAA CCNNTTNTTC GGTTNG GGGP. GGG ^ 60 120 180 240 300 360 420 4B0 S40 600 660 720 780 816 -line-53- This paper size applies to Chinese National Standard (CNS) A4 specification (210X297 mm) 1228593 A7 B7 V. Description of the invention (51) (2) Serial identification number 15 information : (I) Sequence characteristics: (A) Length: 783 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecular type Ξ eDNA (xi) Sequence description Sequence identification number 15 Ξ CCAAGGCCTC GOCAGGCATA NACTTGAAGQ TACAACCCCA GQAACCCCTG GTGCTGAAGG 60 ATGTGGAAAA CACAGATTGG CGCCTACTGG GGGGTGACAC QOATOTCAGG GTAGAGAGGA 120 AAGACCCAAA ccaggtgoaa ctgt gcggac tcaaggaang cacctacctg TTCCAGCTGA 1Θ0 CACSTO ^ CTAG CTCAGACCAC CCAGAGGACA CGGCCAACGT CACAGTCACT GTGCTGTCCA 240 CCAAGCAGAC AGAAGACTAC TGCCTCGCAT CCAACAANGT GGGTCGCTGC CGGGGCTCTT 300 TCCCACGCTG QTACTATGAC CCCACGGAGC AGATCTGCAA GAGTTTCGTT TATGGAGGCT 360 GCTTGGGCAA CAAGAACAAC TACCTTCGGG AAGAAGAGtG CATTCTANCC TGTCNGGOTG 420 TGCAAGGTGG GCGTTTGANA NGCANCTCTG GGGCTCANGC GACTTTCCCC CAGGGCCCCT 480 CCAtGGAAAG GCGCCATCCA NTGTTCTCTG GCACCTGTCA GCCCACCCAG TTCCGCTGCA 540 NCAATGGCTG CTGCATCNAC ANTTTCCTNG AATTGTGACA ACACCCCCCA NTGCCCCCAA 600 CCCTCCCAAG AAAGCTTCCC TGTTNAAAAA TACNCCANTT GGCTTTTNAG AAACNCCCGO 6 ^ 0 CNCCTCCNTT TTCCCGNN ™ AACAAAGGGC NCTNGCNTTT GAACTGCCCN AACCCNGGAA 720 TCTNCCNNGG AAAAANTNCC CCCCCTGGTT CCTNNAANCC CCTCCNCNAA ANCTNCCCCC 780 CCC 7Θ3 (please read the Notes on the back of another page) • installed · Order (2 ) Sequence identification number 16 information: (i) Sequence characteristics: (A) Length: 801 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line

(Ii) MOLECULE TYPE: eDNA (xi) Sequence Description: SEQ ID NO 16: GCCCCAATTC CAGCTGCCAC ACCACCCACG GTGACTGCAT TAQTTCGGAT GTCATAGAAA 60 AGCTGATTGA AGCAACCCTC TACTTTTTGG TCGTGAOCCT TTTGCTTGGT GGAGGTTTCA 12 0 TTGGCTGTGT TGGTGACGTT GTCATTGCAA CAGAATGGGG GAAAGGCACT GTTGTCTTTG 160 AAGTAGGGTG AOTCCTCAAA ATCCGTATAG TTGGTGAAGC CACAGCACTT GAOCCCTTtC 240 ATGGTGOTGT TCCACACTTG AGTGAAGTCT TCCTGGOAAC CATAATCTTT CTTGATGGGA 3〇〇GGCACTACCA GCAACQTCAG GAAGTGCTCA CCCATTOTGO TOTACACCAA GGCOACCACA 3 60 GCAQCTGCAA CCTCACCAAT GAAGATGAGG AGGAGGATGA AGAAGAACGT CNCGAGGCCA 420 -54- this paper scales applicable Chinese national standard (CNS) A4 size (210X297 mm) line _ the central Bureau of standards, Ministry of economic Affairs staff co-op printed 1228593 A7 B7 V. Description of the invention (52) CACTTGCTCT CCGTCTTAGC ACCATAGCAG CCCANGAAAC CAAGAGCAAA GACCACAACG 4 $ 0 CCNGCTGCGA ATGAAAGAAA NTACCCACX5T TGACAAACTG CATGGCCACT GGACGACAGT 540 TGGCCOGAAN ATCTTCAGAA AAGGQATGCC CCATCGATTG AACACCCANA TGCCCACTGC 600 CNAOAGGGCT GCNCCNCNCN GAAAGAATCA GGCATTGi ^ AG AAGGA TCNTC NTGGTCTTAA 660 TGAACTGAAA CCNTGCATGG TCGCCCCTGT TCAGGGCTCT TGGCAGTGAA TTCTGANAAA 720 AAGGAAGNGC NTNAGCCCCG CCAAANGANA AAACACCCCC (3GGTGTTGCC CTGAATTGCC 780 GGCCAAGGAN CCCTGCGCCN G B01 (2) sequence: 2 base sequence) : Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecular type: cDNA (xi) Sequence description: Sequence identification number 17: GTGAQAGCCA GGCGTCCCTC TGCCTGCCCA CTCAGTGGCA ACACCCGGGA GCTGTTTTGT 60 CCTTTGTGGA OCCTCAGCAG TTCCCTCXTG CAGAACTCAAC TAC 120 AGCCACCATG CAGTGCTTCA GCTTCATTAA GACCATGATG ATCCTCTTCA ATTTGCTCAT ΙβΟ CTTTCTGTGT GGTGCAGCCC TGTTGGCAGT GGGCATCTGO GTGTCAATCG ATGGGGCATC 240 CTTTCTGAAQ ATGTTCGGGC CACTGTCGTC CAGTGCCATG CAGTTTC3TCA ACOTGGGCTA 300 CTXCCTCATC GCAGCCGGCG TTGTGOTCTT TGCTCTTGOT TTCCTGGGCT GCTATGGTGG 360 TAAGACGGAG AGCAAGTGTG CCCTCGTGAC GTTCTTCTTC ATCCTCCTCC TCATCTTCAT 420 TGCTGAAGTT GCAGCTGCTG TGGTCGCCTT GGTGTACACC ACAATGGCTG AACCATTCCT 4 80 GACGTTGCTG GTANTGCCTG CCATCAANAA AGATT ATGGG TTCCCAGGAA AAATTCACTG 540 AANTNTGGAA CACCNCCATO AAAAGGGCTC CAATTTCTGN TGGCTTCCCC AACTATACCG 600 GAATTTTGAA AGANTCNCCC TACTTCCAAA AAAAAANANT TGCCTTTNCC CCCNTTCTGT 660 TGCAATGAAA ACNTCCCAAN ACNGCCAATN AATlACCTGCG CNNNCAAAAA GGNTCNCAAA 720 CAAAAAAANT NNAAGGOTTN 740 (Please read the cautions on the back of another m this page) • · installed, Ministry of Economic Affairs quasi-Su Printed by the Bureau's Consumer Cooperative (2) Sequence Identification No. 18: ⑴ Sequence Features: (A) Length: 802 base pairs (B) Type: Nucleic acid (C) Stock type: Single strand (D) Topology: Straight-55- This paper size applies Chinese National Standard (CNS) A4 (21 ×: 297 mm) 1228593 A7B7 V. Description of the invention (53) Printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs (ii) Molecular type: CDNA (xi) sequence description: Sequence identification number 18: CCGCTGGTTG CGCTGGTCCA GNGNAGCCAC GAAGCA.CGTC AGCATACACA GCCTCAATCA 60 CAAGGTCTTC CAGCTGCCGC AGATTACGCA GGGCAAGAGC CTCCAGCAAC ACTGCATAGCCTCGGTCGGTCGGTAGGTCTQGTCA GO CTTCAGCTAA GTAGTCAGCG TATGTCCCAT 240 AAGCAAACAC TGTGAOCAGC CGGAAGGTAG AGGCAAAGTC ACTCTCAGCC AGCTCTCTTAA 3 00 CATTGGGCAT GTCCAOCAGT TCTCCAAACA CGTAGACACC AGNGGCCTCC AGCACCTQAT 360 GGATGAGTGT GGCCAGCGCT GCCCCCTTGG CCGAGTTGGC TAGGAGCAGA AATTCCTCCT 420 GGTTCTGCCC TGTCACCtTC ACTTCCGCAC TCATCACTGC ACTGAGTGTG GGGGACTTGG 480 OCTCAGGATG TCCAGAGACG TGGTTCCGCC CCCTCNCTTA ATGACACCGN OCANKCAACC 540 GTCGGCTCCC GCCGANTGNG TTCGTCGTNC CTGGGTCAGG GTCTGCTGGC CNCTACTTGC 600 aancttcgtc nggcccatgg aattcaccnc accggaactn gtangatcca ctnnttctat MO AACCGGNCGC CACCGCNNNT CG7VACTCGAC TCTTNTTNCC TTTACTTGAG GGTTAAGGTC 720 ACCCTTUMCG TTACCTTGGT CCAAACCNTN CCNTGTGTCG ANATNGTNAA TCNGGNCCNA. NC TCB number: 780 TCB ) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Linear (ii) Molecular type: cDNA (xi) Sequence description: Sequence identification number 19: CNAAGCTTCC AGQTNACGGO CCGCNAANCC TGACCCNAQG TANCANAANG CAGNGNGCGG 60 GAGCCCACCG TCACGNGGNG GNGTCTTTAT NGGAGGGGGC GGAQCCACAT CNCTQGACNT 120 CNTGACCCCA 7VCTCCCCNCC NCNCANTGCA GTGATGAGTG CAGAACTGAA GGTNACOTGG 1B0 CAGGAACCAA GANCAAMfNC TGCTCCNNTC CAAGTCGQCN NAGCSGGGCGG GGCTGGCCAG 240 GCNCATCCNT CNAGTGCTGN AAAGCCCCNN CCTGTCTACT TGTTTGGAGA ACNGCNUNGA 3〇〇CATGCCCAGN GTTANATAAC NGGCNGAGAG TNANTTTGCC TCTCCCTTCC GGCTGCGCAN 3SO CGNGTNTGCT TAGNGGACAT AACCTGACTA CTTAACTGAA CCCNNGAATC TNCCNCCCCT 420 CCACTAAGCT CAGAACAAAA AACTTCGACA CCACTCANTT GTCAdCTGNC TGCTCAAGTA 4B〇 AAGTGTACCC CATNCCCAAT GTNTGCTNGA NGCTCTGNGC TGCNTTANGT TCGGTCCTGG S40 QAAGACCTAT CAATXNAAGC TATGTTTCTG ACTGCCTGTT GCTCCCTGNA ACAANCaiACC 600 CNNCNNTCCA AGGGGGGONC GGCCCCCAAT CCCCCCAACC NTNAATTNAN TTTANOCCCN 660 CCCCCNGGCC CGGCCTTTTA CNANCNTCNN NKACNGGGNA AAACCNNNGC TTTNCCCAAC 720 NNAATCCNGC T 731 -56- this paper scales applicable Chinese national standard (CNS) A4 size (210X297 mm ) (Please read the notes on the back before -ijll this page).

1T line 1228593 A7 B7

V. Description of the invention (54) (2) Information on sequence identification number 20: ⑴ Sequence characteristics: (A) Length: 754 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology : molecular type ·· cDNA (xi) sequence Description linear (ii): SEQ ID NO 20: ττττττττττ τττττττχττ taaaaacccc ctccattnaa tgnaaacttc cgaaattgtc eo CAACCCCCTC NTCCAAATNN CCNTTTCCGG GKGGGCGTTC CAAACCCAAN TTANNTTTGG '120 ANNTTAAATT AAATNTTNNT TGGNOGNNNA ANCCNAATGT NANGAAAOTT NAACGC ^ NTA 180 TNANCTTNAA TNCCTGGAAA CCNGTNGNTT CCAAAAATNT TTAACCCTTA ANTCCCTCCG 240 AAATNGTTNA NGGAAAACCC AAKTTCTCNT AAGGTTGTTT GAAGGNTNAA T ^ TAAAANCCC 300 NNCCAATTGT TTTTNGCCAC GCCTGAATTA ATTGGNTTCC GNTGTTTTCC NTTAAAAKAA 360 GGNNANCCCC GGTTANTNAA TCCCCCCNNC CCCAATTATA CCGANTTTTT TTNGAATTGO 420 QANCCCNCGO GAATTAACGG GGNNNNTCCC TNTTGGGGGG CNGCNNCCC? C CCCCNTCGGG 480 GOTTNOGGNC AGGNCNNAAT TGTTTAAGGG TCCGAAAAAT CCCTCCNAGA AAAAAAKCTC. 540 CCAGGNTGAG NNTNGGGTTT NCCCCCCCCC CANGCCCCCT CTCGNANAGT TGGGGTTTGG 600 GGGGCCTGGG ATTTTNTTTC CCCTNTTNCC TCCCCGC CCC CCNGGGANAG AGGTTNGNGT 660 TTTGNTCNNC GGCCCCNCCN AAOANCTTTN CCGANTTNAN TTAAATCCNT GCCTNGGCGA 120 AGTCCNTTG ^ T AGGGNTAAAN GGCCCCCTNN CGGG 754 (Please read the notes on the back first and then this page) • Assembling · Ordering (2) Sequence identification No. 21 sequence information · A) Length: 755 base pairs (B) Type: Nucleic acid (C) Stock type: Single strand, printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs

(D) Topology: Straight line (ii) Molecular type: cDNA (xi) Sequence description: Sequence identification number 21: ATCANCCCAT < 3ACCCCNAAC NNGGGACCNC TCANCCGGNG NNNCNACCNC CGGCCNATCA 60 NNQTNAGNNC ACTNCNNTTN NATCAC3ffCC〇'CNCCNACTAC GCCCNCNANC CNACGCNCNC NCNCGCNCNC NCACGCNCNC NCNCGCNCNC ACC 180 GCAGCTGTCG NANAAKGCCT NNNATACNGG NNNATCCAAT NTGNANCCTC CNAAGTATTN 240 NMCNNCANAT GATTTTCCTN ANCCGATTAG CCNTNCCCCC TANCCCCTCC CCCCCA? VCNA 300 CGAAGGCNCT GGNCCNAAGG NNGCGNCNCC CCGCTAGNTC CCCNNCAAGT CNCNCNCCTA 350 AACTCANCCN NATTACiNCGC TTCNTGAGTA TCACTCCCCG AATCTCACCC TACTCAACTC 420 -57- this paper scales applicable Chinese national standard (CNS) A4 size (210X297 mm ) 1228593 A7 B7 V. invention is described in (55) AAAAANATCN GATACAAAAT AATNTCAAGCC TGNTTATNAC ACTNTGACTG GGTCTCTATT 480 TTAGNGGTCC NTNAANCNTC CTAATACTTC CAOTCTNCCT TCNCCAATTT CCNAANGGCT 540 CTTTCNGACA GCATNTTTTG GTTCCCNNTT GGGTTCTTAN NGAATTGCCC TTCNTNGAAC 600 GGGCTCNTCT TTTCCTTCGG TTAKCCTGGN TTCNHCCGGC CAOTTATTAT TTCCCNTTTT S60 AAATTCNTNC C KTTTAITTTT TGGCNTTCNA AACCCCCGGC CTTGAAAACO GCCCCCTGGT 720 AAAAGGTTGT TTTGANAAAA TTTTTGTTTT GTTCC 755 (2) Sequence identification number 22: ⑴ Sequence characteristics: (A) Length: 849 base pairs (B) Type: Nucleic acid (C) Share type: Single strand ( D) in topology: linear (ii) mOLECULE tYPE: cDNA (xi) sequence Description: SEQ ID NO 22: TTTTTTTTTT TTTTTANGTG TNGtCGTGCA GGTAGAGGCT TACTAOAANT GTGAANACGT 6〇ACGCTNGOAN TAANGCGACC COANTTCTAG OANNCNCCCT AAAATCANAC TGTGAAGATN 120 ATCCTGNimA CGGAANGGTC ACCGGNNGAT NNTGCTAGGO TGNCCNGTCC CANIINCNTTN CATAACTCNG NGGCCCTGCC CACCACCTTC GGCGGCCCNG NGNCCGGGCC CGGOTCATTN 240 GmrrTAACCN CACTNNGCNA NCGGTTTCCN NCCCCNNCNG ACCCNGGCGA TCCGGGGTNC 3 00 TCTGTCTTCC CCTGNAGWCN ANAAANTGGG CGNCGGNCCC CTTTACCCCT NNACAAGCCA 360 CNGCGNTCTA NCCNCNGCCC CCCCTCCANT NlTGGGGGACT GCCNANNGCT CCGTTNCTNG. 420 NNACCCCNWN GGGTNCCTCG GTTGTCGANT CNACCGNANG CCANCGATTC CNAAGGAAGG 4Θ0 TGCGTTNTTG GCCCCTACCC TTCGCTNCGG NNCACCCTTC CCGACNANGA NCCGCTCCCG 540 CNCNNCGNITG CCTOtTCCTCG CAACACCCGC NCTCNTCNGT NCGGNNNCCC G CCCACGCGC 600 NCCCTCNCNC NGNCGNANCN CTCCNCCNCC GtCTCANNGA CCACCCCGCC CCGCCAGGCC NTCANCCACN GGNNGACNNG NAGCtJCNNTC GCNCCGCGON GCGNCNCCCT CGCCNCNGAA 720 CTNCNTCNGG CCANTNNCGC TCAANCCNNA CNAAAOTCCG CTGCGCGGCC CGNAGCGNCC 780 NCCTCCNCGA GTCCTCCCGN CTTCCNACCC ANGNWTTOCN CGAGGACACN NITACCCCGCC 840 NNCANGCGQ 849 (please read the Notes on the back page again • installed - line, the central Ministry of Economic Affairs Standards Bureau's Consumer Cooperation 衽 Printed (2) Information on Sequence Identification No. 23: ⑴Sequence Features: (A) Length: 872 base pairs (B) Type: Nucleic Acid, (C) Stock Type: Single Stock (D) Topology: Straight-58- This paper is suitable for Chinese National Standard (CNS) A4 (2I0X297 mm) 1228593 A7B7

Fifth, the invention is described in (56) (ii) MOLECULE TYPE: cDNA (xi) Sequence Description: SEQ ID NO 23: GCGCAAACTA TACTTCGCTC GNAGTCGTGC GCCTCGCTNC TCTTTTCCTC CGCAACCATG 60 TCTGACNANG CCGATTNGGC NGATATCNAXi AAGNTCGANC AGTCCAAACT GANTAACACA 120 CACACNCNAN AGANAAATCC NCTGCCTTCC ANAGTANACN ATTGAACNUG AGAACCANGC 180 NGGCGAATCG TAATNAGGCG TGCGCCGCCA ATNTQTCNGC GTTTATTNTN CCAOCNfCNfC 240 CTNCCNACCC TACNTCTTCN NAGGTGTCNN ACCCCTNGTN CGNACCCCCC NAGOTCGGGA 300 TCQGGTTTNN NNTGACGGNG CNNCCCCTCC OCCCNTCCAT NACGANCCNC CCGCACCACC 360 NANNGCNCGG NCCCCGNNCt CTTCGCCNCC CTGTCCTNTN CCCCTGTNGC CTOGCNCNGW 420 ACCGCATTGA CCCTCGCCNN CTNCNNGAAA NCGHANACGT CCGGGTTGNN AMiANCGCTG 480 TGGGN1TNGCG TCTGCNCCGC GTTCCTTCCN NCNNCTTCCA CCATCTTCNT TACNGGGTCT 540 CCNCGCCNTC TCNNNCACNC CCTGGOACGC TNTCCTNTGC CCCCCTTNAC TCCCCCCCTT ¢ 00 CGNCGTGKCC CGNGGCCACG NTCATTTNGA NACGNTCTTG ACAANNNCCT GONTNNCTCC «0 CNANOTGNCN GTCANCOTAG GGAAGGGNGG GGNWCCNNTG NTTGACGTTG NGGNGANGTC 720 CGAANANTCC TCNCCNTCAN CNCTACCCCT CGGGCGmCT CTCNGTTNCG AACTTANCAA. 7 80 NTCTCCCCCO NONGCNCNTC TCAQCCTCMC CCNCCCCNCT GTCTGCANTG TNCTCTGCTC 840 TNACCN1TTAC QANTNTTCGN CNCCCTCTTT CC 872 (2) Information on sequence identification number 24: (i) Sequence characteristics: (A) Length: 815 base pairs (B) Type: Nucleic acid (C) Stock type : Single strand (D) topology: straight line (ii) molecular type; cDNA (xi) sequence description: sequence identification number 24: (Please read the precautionary number on the back first! Ul page)

, 1T, Ministry of Economic Affairs Bureau of Standards employees consumer cooperatives printed GCATGCAAGC TTGAGTATTC TATAGNGTCA CCTAAATANC TTGGCNTAA.T CATGGTCNTA- stone 〇NCTGNCTTCC TGTGTCAAAT GTATACNAAN TANATATGAA TCTNATNTOA CAACANNGTA 12 0 TCOTNCATTA GTAACAANTG TNNTGTCCAT CCTGTCNGAN CANATTCCCA TNNATTNCGN 1Α〇CGCATTCNCN GCNCANTATN TAATNGGGAA NTCNNNTNNN NCACGNNGAT CTATCNTNCC 240 GCNCCCTGAG TGGNAGAGAT GCATNANTTC TNNTNTGACC NACATGTTCA TCTTGGATTN 300 AANWTCCCCC CGCNGNCCAC CGGTTNGNNG CNAGCCNNTC CCAAGACCTC CTGTGGAGGT 360 AACCTGCGTC AGANNCATCA AACNTGGGAA ACCCGCNUCC ANGTNNAAGT NONNKCANAN * 420 GATCCCGTCC AGGNTTNACC ATCCCTTCNC AGCGCCGCCT TTNGTGCCTT ANAGNONAGC 480 GTGTCCNANC CTCTCAACAT GA1TACGCGCC AGNCCANCCG CAA.TTNGGCA CAATGTCGNC. 540 GAACCCCCTA GGGGGANTNA TNCAAANCCC CAGGATTGTC CNCNCANGAA ATCCCNdANC 600 CCCNCCCTAC CCNNCTTTGa GACNGTGACC AANTCCCGGA GTTiCCAGTCC GGCCNGNCTG 660 CCCCACCGGT NlvTCCNTGGGG GGGTGAANCT CNGNNTCANC CNGNCGAGGN NTCONAAGGA 720 ACCGGNCCTO GGNCGAANNG AInTCNKTCNGA AGNGCCNCNT CGTATAACCC CCCCTCNCCA 780 NCCNACNGN T AGNTCGCCCC CNGGGWCGG AANGG 815 (2) Information on serial identification number 25: (i) Sequence characteristics · ** 59-This paper size applies Chinese National Standard (CNS) A4 specification (2IOX297 mm) 1228593 A7 B7 V. Description of the invention (57) (A) Length: 775 base pairs (B) Type · Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecular type: cDNA (xi) Sequence description: Sequence recognition No. 25 ·· CCGAGATGTC TCGCTCCGTO GCGTTAjGCTG TGCTCGCGCT ACTCTCTCTT TCTGGCCTGG AGGCtATCCA GCX3TACTCCA AAGATTCAGG TTTACTCACG TCATCCAGCA GAGAATGGAA 120 AGTCAAATtT CCTOAATTGC TATGTGTCTG CGTTTCATCC ATCGGACATT GAANTTGACT ISO TACTGAAGAA TGGAHAGAGA ATTGAAA71AG TGGAGGATTG AGACTTGTCT TTCACGAAGQ 240 ACTGGTCTTT CTATCTCMTG TACTACACTG AATTCACCCC CACTOAAAAA GATGAGTATG 3〇〇CCTGCCGTGT GAACCATGTG actttgtcac agcccaagat AGTTAAGTGG GATCGAGACA 3 ^ 0 TGTAAOCAGN CNNCATGOAA GTTTGAAGAT QCCGCATTTG GATTGGATGA ATTCCAAATT 420 CTGCTTCCTT GCNTTTTAAT ANTGATATGC NTATACAGCC TACCCTTTAT GNCCCCAAAT 480 TGTAGGGGTT ACATNANTGT TCNCNTNdGA CATGATCTTC CTTTATAANT CCNCCNTTCG S40 AATTC3CCCOT CNCCCNGTTN NGAATGTTTC CNNAACCACG GTTGGCTCCC CCAGGTCNCC 60〇TCTTACQQAA GGGCCTGGGC CNCTTTNCAA G0TTGGGC3GA ft.CCNAAAATT TCNCTTNTGC 660 CCNCCCNCCA CXmTCTTGNG NNCNCANTTT GGAACCCTTC CNATTCCCCT TGGCCTCNWA. ^ 20 NCCTTNNCTA ANAAAACTTN AAANCQTNGC ΝΛΑΑΝΝΤΤΤΝ ACTTCCCCCC TTACC 775 (Please re-read the notes on the back of this page) • installed · Order ( 2) Information on sequence identification number 26: (i) Sequence characteristics: ΥΑ) Length · 820 base pairs (B) Type: Nucleic acid (C) Strand type · Single strand (D) Topology: Straight line

(Ii) MOLECULE TYPE: cDNA (xi) Sequence Description: SEQ ID NO 26: ANATTANTAC AGTGTAATCT TTTCCCAGAG GTGTGTANAG GGAACGGGGC CTAGAGGCAT 60 CCCANAGATA NCTTATANCA ACAOTGCrTT GACCAAGAGC TGCTGGGCAC ATTTCCTGCA 120 GAAAAGGTGG CGGTCCCCAT CACTCCTCCT CTCCCATAGC CATCCCAGAG GGOTGAGTAG 18 ° CCATCANGCC TTCGGTGGGA GGGAGTCANQ GAAACAACAN ACCACAGAGC ANACAGACCA 240 NTGATGACCA TGGCCGGGAG CGAGCCTCTT CCCTGNACCG GGGTGOCANA NGANAGCCTA 300 NCTGAGGGGT CACACTATAA ACGTTAACGA CCNAGATNAN CACCTGCTTC AAGTGCACCC 3 60 TTCCTACCTG ACNACCAGNG ACCNNNAACT GCNGCCTGGG GACAGCNCTG GGANCAGCTA 420 ACNNAGCACT CACCTGCCCC CGCATGGCCG TNCGCNTCCC TGGTCCTGNC AAGGGAAGCT 40 0 CCCTGTTGGA ATTNCGGGGA NACCAAGGGA NCCCCCTCCT CCAKCTGTGA AGGAAAAANN 540 GATGGAATTT TNCCCTTCCG GCCNNTCCCC TCTTCCTTTA CACGCCCCCT NNTACTCNTC 600 TCCCTCTNTT NTCCTGNCNC ACTTTTNACC CCNNNATTTC CCTTNATTGA TCGGAKNCTN C60 GANATTCCAC TNNCGCCTNC CNTCNATCNG NAANACNAAA NACTNTCTNA CCCNGGGGAT 720 GGGNNCCTCG NTCATCCTCT CTTTTTCNCT AGCNCCNNTT CTTTdCGTCT CCTTNGATCA 780 TCCAACCNTC GNTGGCCNTN C CCCCCCNNN TCCTTTNCCC S2〇-60- This paper size applies to Chinese National Standard (CNS) A4 (210X297 mm) line_, printed by the Central Consumers Bureau of the Ministry of Economic Affairs Consumer Cooperatives 1228593 A7 V. Description of the invention (58 (2) sequence Information identifying No. 27: (i) Sequence characteristics: (A) Length: 818 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecular type: eDNA (xi) Sequence description: Sequence identification number 27

TCTGGGTOAT TGTTTCTTCT CTGCGGMGC CTGCTGAGCA TCCGCCTCCA TTCTTCCTGC GATCTCAGTT TATNACCNAN NCTCCCTTCC CTCCTTTGCO CTGNTNNCCC TNNCTCTTCN CNNNTGHANG CCCNNCGGCC

GGCCTCTTCC CCGAGCCCCA TOTGACGCAC cttccgcccc GGGTTCTGCT CCCNTCCCTG TCCCTCNCTC TGGNCTOTNC ANTTCNliNNA CTNACCANGG CNCTCNCNNT KGTNTCGNAA TNNTTNliNNC NGNATTAAGO

TCCTCAGC3GA GGCAGCGGTG CCAAGGGGCA TCACCCTGCC CTTCCANGCA GCTCTGANTC ANNGAACTCT TGTCNNACTT NC .CCQ TNCCTCOTCC NGNTCNCNTN NCNGNNCCCC CCTCCNNTCT

ACCNGCTTK GCCNNNACC

CCTCTGACTO ATTCAGCCCT AATAGGGTCC CAGCCCCTGC NGCCAKCAAG TCTQTCTTCC GTTTCTGANN TAATGGGCCKf CNTCNTCTCG CCCNTNUCTH CmrCNNCOCN TNNNNNGNCN NNNliCNNNNN CCGGCCNC

CTCTGGGCCA GCCCAACCTG CAGGGTCCAG CATGAGCTCT TGGCGCTGGG TGTCi TCTT < GACCGGCTAA CCNTANCCCG ggggggcnng NNGGANNTTC NGNTNNTNCN NGGNNNTNNN

: CTGTGC rCANTTA

AAGAATCTCT ATTCTGATGK ggaggcgcgc GGGCTGGGTC CCACACTGGC ANGCNOCTTG ACTNTGANTT TCCCTCCCTC CCNGGGAANC GTNNGTNCNC NCNGTCCCNW TCCCTCTCNC TCTNCNCNGC 60 120 180 240 300 ZS0 420 4B0 S40 600 660 1 720 BO 720 7

, 1T • Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs

(2) Information on sequence identification number 2S ... Sequence characteristics: (A) Length: 731 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecules type: cDNA (xi) sequence Description: SEQ identification exit No. 28: AGGAAGGGCG GAGGGATATT GTANGGGATT GAGGGMAGG AGNATAANGG GGGAGGTGTG TCCCAACATG ANfGGTGNNGT TCTCTTTTGA ANGAGGGTTG NGTTTTTANN CCNGGTGGGT GATTNAACCC CATTGTATGG AGNNAAAGGN TTTNAGGGAT TTTTCGGCTC TTATCAGTAT NTANATTCCT GTNAATCGGA AAATNATNTT TCNNOXGGAA AATNTTGCTC CCATCCGNAA ATTNCTCCCG GGTAGTGCAT NTTNGGGGGN CNGCCANGTT TCCCAGGCTG CTiVNAATCGT ACTAAAGNTT NAAGTGGGAN TNCAAATGAA AACCTNNCAC. AGAGNATCCN TACCCGACTG 60 120 180 240 300 3β〇-line--61-This paper size applies Chinese National Standard (CNS) A4 specification (210X297 mm) 1228593 ΑΊ Β7 V. Description of the invention (59)

TmJNTTUCCT TCGCCCTNTG ACTCTGCNNG AGCCCAATAC CCNKGNGWAT GTC1TCCCNGN 420 NNNGCGNCNC TG7VAANNNNC TCGNGGCTNN GANCATCANG GGGTTTCGCA TCAAAAGCNN 4 80 COTTTCNCAT NAAGGCACTT TNOCCTCATC CAAGCNCtNG CCCTCNNCCA TTTNGCCGTC S40 NGGTTCNCCT ACGCTNNTNG CNCCTNWNTN GANATTTTNC CCGCCTNGGG NAANCCTCCT 600 GNAATGGGTA GGGNCTTNTG TTTTNACCNN GNGGTNTACT AATCNNCTNC ACGCTTNCTT 660 TCTCNACCCC CCCCCTTTTT CAA.TCCCANC GGCNAATGGG GTGTCCCCNIT CGAISrGGGGCG 72 0 NNNCCCANNG C 731 ( 2) Information on sequence identification number 29: (i) Sequence characteristics: (A) Length: 822 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecules type: cDNA (xi) sequence Description: SEQ ID NO 29: ACTAGTCCAG TGTGGTGGAA TTCCATTGTG TTGGGGNCNC TTCTATGANT ANTNTTAGAT 60 CGCTCANACG TCACANCCTC CCNACNANGC CTATAANGAA NANUAATAGA NCTGTNCNNT 120 ATNTNTACNC TCATANNCCT CNN1TACCCAC TCCCTCTTAA CCCNTACTGT GCCTATNGCN 1θ〇TNNCTANTCT NTGCCGCCXN CNANCCACCN GTGGGCCNAC CNCNNGNATT CTCNATCTGC 240 TCNCCATNTN GCCTANANTA NOTNCA.TACC CTATACCTAG NCCAATGCTA NNNCTA ANCN 300 TCCATNANTT ANNNTAACTA CCACTGACNT NGACTTTCNC ATNANCTCCT AA.TTTGAATC 360 TACTCTGACT CCCACNGCCT ANNNATTAGC ANONTCCCCC NACNATNTCT CAACCAAATC 420 NTCAACAACC TATCTANCTG TTCNCCAACC NTTNCCTCCG ATCCCCNNAC AA.CCCCCCTC 4 80 CCAAATACCC NCCACCTGAC NCCTAACCCN CACCATCCCG GCAAGCCNAN GGNCATTTAN · 540 CCAGTCGAAT CACNATNGGA NAAAAAAAAC CCNAACTCTC TANCNCNNAT CTCCCTARNA 600 AATNCTCCTN NAATTTACTO NCANTNCCAT CAANCCCACN TGAAACNNAA CCCCTGTTTT 660 TANATCCCTT CTTTCGAAAA CCNACCCTTT ANNNCCCAAC CTTTNGGGCC CCCCCNCTNC 720 CCNAATGAAG GNCNCGCAAT CNAHGAAACG NCCNTGAAAA ANCNAGGCNA ANANTrtlTCCG 780 CANATCCTAT CCCTTANTTN GC3GGNCCCTT NCCCNGGGCC CG Please read on the back of this page.

Line 1T • Printed by the Consumer Cooperatives of the Central Bureau of Standards of the Ministry of Economic Affairs

(2) Information on sequence identification number 30: ⑴ Sequence characteristics: (A) Length: 787 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand, (D) Topology · Straight line (ii) Molecular type: cDNA ___ 62 The size of the male paper is applicable to the Chinese National Standard (CNS) A4 (210x297 mm) 1228593 A7 B7 V. Description of the invention (60) (xi) Sequence description: Sequence identification number 30: CGGCCGCCTG CTCTGGCACA TGCCTCCTGA ATGGCATCAA AAGTGATGGA CTGCCCATTG 60 CTAGAGAAGA CCTTCTCTCC TACTGTCATT ATGOAGCCCT GCAGACTGAG GGCTCCCCTT 120 GTCTGCAGGA TTTGATGTCT GAAOTCGTGO AOTGTGGCTT GGAGCTCCTC ATCTACATNA 180 GCTGQAAGCC CTGGAGGGCC TGTCTCGCCA GOCTCCCCCT TCTCTCCACG CTCTCCANGG 240 ACAGCAGGGG CTCCAGGCAG CCCATTATTC CCAGNANGAC ATGGTGTTTC TCCACGCGGA 300 cccatggggc ctgnaaggcc agcgtctcct ttgacaccat ctctcccgtc CTGCCTGGCA 3 ^ 0 GGCCGTGGGA TCCACtANTT CTANAACGGN CGCCACCNCG GTGGGAGCTC CAGCTTTTGT 420 TCCCNTTAAT GAAGGTTAAT TGCNCGCTTG GCGTAATCAT NGGTCANAAC TNTTTCCTGT 480 GTGAAATTGT TTNTCCCCTC NCNATTCCNC NCNACATACN AACCCGQAAN CATAMGTGT 540 TAAAGCCTGG GGGTNGCCTN NNGAATOAA C TNAA.CTCAAT TAATTGCGTT GGCJTCATGGC ¢ 00 CCGCTTTCCN TTCNGGAAAA CTGTCNTCCC CTGCNTTNNT GAATCGGCCA CCCCCCNGGG 660 AAAAGCGGTT TGCNTTTTNG GGGGNTCCTT CCNCTTCCACC2 CGGGTCCGTCNGTCNG CCNG ) Length: t99 base pairs (B) Class: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecular type: cDNA (xi) Sequence description: Sequence recognition 3 No. 1 (read Notes on the back read it again this page) installed · Ministry of economic Affairs Bureau of standards Co-op members Η printed TTTTTTTTTT TTTTTTTGGC C3ATGCTACTG TTTAATTQCA GGAGGTGGGQ GTGTGTOTAC CATGTACCi, G GGCTATTAGA ACCAAGAAGG AAGGAQGGAG GGCAQAGCGC CCTGCTGAGC 120 AACAAAGGAC TCCTGCAGCC TTCTCTGTCT GTCTCTTGGC GCAGGCACAT (3GGGAGGCCT CCCGCAGGGT GGGGGCCACC AGTCCAGGGC? TGGGAGCACT ACANGGGGTG GGAGTGGGTG 240 GTGGCTGaTN CNAATGGCCT GNCACANATC CCTACGATTC TTGACACCTG GATTTCACCA 3 ° OGGGACCTTC TGTTGTCCCA NGGNAAGTTC NTNNATCTCN AAAGAACACA ACTaTTTCTT 360 C NGCANTTCT GGCrrGTTCA.T GGAAAGCACA GGTGTCCNAT TTNGGCTGGG ACTTGGTACA 420 TATGGTTCCG GCCCACCTCT CCCNTCNAAN AAGTAATTCA CCCCCCCCCN CCNTCTNTTG 4 Day 0 CGTGGGCCCT TAANTACCCA CACCOGAACT CANTTANTTA TTCATCTTNG aNTGGGCTTG 54 0 NTNATCNCCN CCTGATINGCG CCAAGTTGAA AGGCCACC3CC GTNCCCNCTC CCCATAGNAW θ〇α NTTTTNNCNT CANCTAATGC CCCCCCNGGC AACNATCCAA TCCCCCCCCN TGGGGGCCCC 660 AGCCCMJGGC CCCCGNCTCG GGNNNCCNGN CNCGNANTCC CCAGGNTCTC CCANTCNGNC 720 CCNNNGCNCC CCCGCACGCA GAACANAAGG liTNGAGCCNG CGCANNNNNN NGGTNNCNAC 780 CTCGCCCCCC CCNNCGNNG, 755 (2) Information of sequence identification number 32: (i) Sequence characteristics: -63 * This paper size applies the Chinese National Standard (CNS) A4 specification (210X297 mm) -line 128593 A7B7 V. Description of the invention (61) (A) Length: 789 base pairs (B) Type: Nucleic acid (C) Strand type · Single strand (D) Topology: Straight line (ii) Molecular type: cDNA (xi) sequence Description: Sequence identification number 32

τττττττττττ TTTTNCCNAG GGCAACAGGC CGCTCCCGCT GGTGGGCACC NATTAGGAAT GCGGCTCCGG NCCNGCCACA GGNCCATGTC CCAAAAOTTC CCCCTTGGCC TGGNNGGCAA NTCCTNNNCA CCCCCCNCG

ΤΤΤΤΤΤΤΤΤΤ GGCAGGTTTA TCCGGCGGCG TGATNTTCCT CTGGGATTTW AOTGCTNTTA CATCTGGTCT ATCATNACTC TTNNCGGCGT TTGNGGGCCN CCCAAATCCT GNTGGNTCCC CCATCCCCCC

ΤΤΤΤΓΤΤΤΤχ TTGACAACCT GCGGCGGCGG CTGCAGCTGC AATTTCCACG CCCNCCNCCG TAAACCTTGC AOACTGGCNC TGCTGCNATN CAAAAAANCT CCCCCCGNTT CCTTCGGGCC NNGNNACGNC

ΤΤΤΤΤΤΤΤΤΤ CNCGGGACAC CCCTACCTGC AGGATGCCNT (3GCACAATGC TTGGCNCACT AAACNCTGOG GGGCTGGCCC TNCATCACCT GCOGGGGGNC NGTGGGTTTG CCCGG1] TANCJ

3GTGGGG: AANGNA

T? TTTTTTTTT AANCAGCCTG GGTACCAAAT AAAACAGGGC GGTCGGANCC CCCCNTGGAA GCCCTCTTTT CAAAAAANCN CCCGGGCNCA CCAGTTTCAA GGAACCCACG CC Li CTCTAA TCCCTTTTTT

τττττττττττ GGGACAGGAC NTGCAGCCCC CTCGGCCNTN CCTCACCACC ACCACTTNTC TGGTTANTMT CCCCAAAACC NCAGGNCAAC CAAAGTCATC CCTCTNNCTT NGAAAACNCC TANAAACGGG 60 120 180 240 300 360 420 4S0 540 600 650 720 7BO 789 ----------------------- (Notes on this page), the member of the Central Standards Bureau of the Ministry of Economic Affairs and the Consumer Cooperative Press (2) Information on sequence identification number 33: (i) Sequence characteristics: (A) Length: 793 base pairs (B) Type: Nucleic acid ( C) Strand type ·· Single strand (D) Topology: Straight line (ii) Molecular type: cDNA (xi) Sequence description: Sequence identification number 33. ·

GACAOAACAT AATTCATGGC GACTAAAGTC AGAAGTTTGC GCACAGATGC ACAANGAACG CTCTGCTGTT GGNCGCCACC TAATC 2ATACG TGGCGTi ACAACA ^

GTTGGATGGT TGTTGGAGCA TGATGAACTT AGATGTATTT CTGTGTGACT GGGCTCGTTT AAACACCCCA GCGGTGGAGG ATGGTCATAN ANCCGGAAGC GGAGCACCTT ATANAACCCC CCCAATCAGA GCAAAGAAGA CCGGTTCTGA ATCACCANTG GCCATCCCTT TCCAGCTTTT CTGTTTCCTG ΑΤΓίΑΑΛΤΤΤΤ TCTATCACGAC TTACAGGAGA GCAGATGGGG 60 AGTTCTACGA GCTGCTGATC AAAGGACTTG 120 TGAGCATGGA TGATTGGCC ^ V GAAATGAANA 180 GTGGTGTCAA ATCTTTGACG 240 GOTTGTTCAT CA.TGATCACA 300 CGTGAGCCCC COCCCTGCAC 360 GGATCCACTA CTTCTAOAGC 420 GTGAdGGTTA ATTGCGCGCT 4Θ0 TGTGAAATTG TTATCCGCTC ACAATTCCAC S40 AAAGCCTGGN GGTNGCCTAA TGANTGAACT: 600

CGAAOGCAGA CTTTTGAGGA AGGAGCAGGA CTTTCAAAAG GTTCCCrTTTA -64 This paper size applies to the Chinese National Standard (CNS) A4 size (210X297 mm) Order line-1228593 A7 B7 V. Description of the invention (62) NAGTCACGA ATCCCCTCTATCCCCCCGGGGCTGCGCGCCGGCGCGCGCGC GCTTTCTCGC TTCCTGAANT CGTTCCCCCC GGTCTTTCGG CTTGCGGCNA ACGGTATCNA CCf (2) Information of sequence identification number 34: ⑴ Sequence characteristics: (A) Length: 756 base pairs (B) Type: Nucleic acid (C) Strand type ·· Single strand (D) Topology Pu Xue: straight line (ii) molecular type: eDNA (xi) sequence description: sequence identification number 34: 6G0 120 7Θ0 793 Please read the precautions on the back first

GCCGCGACCG GOATGTACGA GCAACTCAAG GGCC3AGTGGA ANCAAGTGCG GGGAAWAGCT GGGTCGACTC AAGCTAQTTC ccaaccagag ggaccaagct gaccaaacag cagctaattc ATCQGGGCCC AATGGAGCAT CCTACGCAAN GACATCGCCT CAGCTCAAAT GCTAGTACTT TGATTACAAN GAGCAGCTCC CAGCTCTTGG GCCTCAACCT CCTCTTCCTG CTGTCCCAGA acgganttgc ancggctgcc tgcccaanga catacanacg gtgtcctgoa gcaatactga tgganogcag ctaccncaaa CATCCCCCGC CGAGAGGTAC ACCTTCTTCA TTGACATCCT ATU ^ ATCGCNG GQTTGCTCCA GAAAGGCTNC AANAANATCC ATNCNCTAGT NCTAGAATCO GCCCGCCATG GCGGTGCANC TTACTOAGQG TTNATTGCCG CCCTTGGCGt TATCATGGTC AATTNTTAAC CCCCCACAAT TCCACGCCNA CATTNO

ACCGTAAAAQ TTCTGGAGCT TGGCCCGTGA CCTTCGAGCG CCGAGTCAGG ACCGC3GTCGC AATOTCTACA GTNTTCCTGG GCTCGACACT TTTTCITCTGA CTCCAACCTT ACNCCNGTTN

CCCCAA.TCTT CAACTTCTTG CATACTGGAG CTACATGQCC CTATATGCAC TGANTNCCAC TCNACCACCA CCNAGGGTAA ATGAGGGATG AGGCCCCCGG TCGTTNCCCT CCTGTGTTGA 60 120 1B0 240 300 360 420 480 540 600 6 $ 0 720 756 Ordering Economy and Printing Co., Ltd. : ⑴ Sequence characteristics: (A) Length: 834 base pairs (B) Type: Nucleic acid (C) Strand type · Single strand (D) Topology: Straight line, (ii) Molecular type: cDNA (xi) Sequence description ： Serial identification number 35 65 This paper size is applicable to Chinese national standard (CNS) A4 specification (210X297 mm) 1228593 A7 B7 V. Description of the invention (63) GGGGATCTCT AMATCNACCT GNATGCATGG TTGTCGGTGT GGTCGCTGTC GATGAATAGGATCCATCCATCGATCCATCTCTCAGTCTCTCAG CTTCAGCT GTCTTGATTT CACCTCCAAT 18 0 AATCTTCNGG GCTGTCTGCT CGGTGAACTC GATGACNANG GGCAGCTGGT TGTGTNTGAT 24 0 AAANTCCANC AHGTTCTCCT TGGTGACGTC CCCTTCAAAG TXGTTCCGGC CTTCATGAAA 300 CTTCTNNAAN ANGANGANCC CANCTNATGGATCGA CCCAA? \. TGGT ATGTCATCCA TCGCCTCTGC TGCCTGCAAA AAACTTGCTT 420 GGGNTCAAATC CGACTCCCCN TCCTTGAAAG AAGCCNATCA CACCCCCCTC CCTGGACTCC 480 NNCAANGACT CTNCCGCTNC CCCNTCCNNG CAGGGTTGGT GOCANNCCGG GCCCNTGCGC S4〇TTCTTCAGCC AGTTCACNAT NTTCATCAGC CCCTCTGCCA GCTGTTNTAT TCCTTGCGOG 600 GGAANCCGTC TCTCCCTTCC TGAANNAACT TTGACCGTNG GAATAGCCGC GCNTONCCNT 660 ACNTNCTGGG CCGGOTTCAA ANTCCCTCCN TTGNCNNTCN CCTCGGGCCA XTCTGOATTT 720 NCCNAACTTT TTCCTTCCCC CNCCCCNCGG KGTTTGGNTT TTTCATNGGG CCCCAACTCT 780 GCTNTTGGCC ANTCCCCTGG GGGCNTNTAN CNCCCCGTNT GGTCCCNTNQ GGCC 834 (2) Sequence identification number 36: (i) Sequence characteristics: (A) Length: 814 base pairs (B) Type: Nucleic acid (C) Genotype: Single strand (D) Topology: straight line (ii) Molecular type: cDNA (xi) Sequence description: Sequence identification number 36: (Please read the notes on the back before this page) CGPrinted CGGNCGCTTT GCNGCCGCGG CCCGTTTGC ^ tGACNAAGGC TCCCTTCANG TTAAATACNN 60 CCTAGNAAAC ATTAATGGGT TGCTCTACTA ATAGATCATA CNAA-CCAGTA AOCCTG CCCA 120 NAACGCCAAG TCAGGCCATT CCTACCAAAQ GAAGAAAGGC TGGTCTCTCC ACCCCCTGTA 180 GGAAAGGCCT GCCTTGTAAG ACACCACAAT KCGGCTC3AAT CTNAAGTCTT GTGTTTTAGT 240 AATGGAAAAA AAAAATAAAC AANAGGTtTT GTTCTCATGG CTGCCCACCG CAGCCTGGCA 3〇〇CTAAAACANC CCAGCGCTCA CTTCTGCTTG GANAAATATT CTTTGCTCTT TTGGACMCA 360 GGCTTGATGG TATCACTGCC ACNTTTCCAC CCAGCTQOGC NCCCTTCCCC CATNTTTGTC 420 ANTGANCTGG AAGGCCTGAA NCTTAGTCTC CAMAGTCTC NGCCCACAAG ACCGGCCACC 48〇AGGGGANGTG NTTTNCAGTG GATCTGCCAA ANANTACGCN TATCATCNNT GAATAAAAAG 540 GCCCCTGAAC GANATGCTTC CANCANCCTT TAAGAGCCAT AATCCTNGAA CCATGQTGCC CTTCCX3GTCT GATCCNAAAG GAATGTTCCT GGGTCCCANT CCCTCCTTTG TTNCTTACQT 660 TGTNTTGGAC CCNTGCTNGN ATNACCCAAN TGANATCCCC iiGAAGCACCC TNCCCCTGGC 720 ATTTGiiUTTT CNTAAATTCT CTGCCCTACN NCTGAAAGCA CNATTCCCTN GGCNCCNAAN 780 GGNOAACTCA AGAAGOTCTN NGAAAAACCA CNCN 814 (2) SEQ ID information number of 37: ⑴ sEQUENCE cHARACTERISTICS: (A) Length: 760 base pairs (B) Type: Nucleic acid-66- This paper size applies Chinese National Standard (CNS) A4 specification (210X297 male) ) Line _ 1228593A7B7, Ministry of Economic Affairs Bureau of Standards employees consumer cooperatives printed V. Description (64 invention)

(C) Stock type: Single-strand (D) Topology: Straight line (ii) Molecular type: eDNA (xi) Sequence description: Sequence recognition CATGCTGCT CTTCCTCAAA GTTGTTCTTG GCGCAGTGTT CGCTGAAGGO GTTGTAGTAC GTGTCTGCCA GGTCCAGTGCGCCATCCATCACACACTCTGTCACTCTCACTCTCACAC. CCAAAGGTAG TGCTCCGTGG GTTTGAATGG GTTAACNTTG GGTANGTGCC CTAAAAATCO

Gi

CNCCTNANCC ACTCl TTGCi GANCCNCCTT CAATTGAACT ACTGGAAAAA CTCCTGTNCC

DTTCTTC ^ AAAATC

CTCAAAGGCC TTGTTCTXGT GC? ATCATNNN NAAGGNAATA GGCCGNGTTC TTCCXTGAAT TNTTCCCCCC

No. 37: TTGCCATAAC CAGCGCGGGA TCACTGGGGA GCCTCCTCCG CANCAGCCCA GGCCTTTCCA ACCTTGCACA TGCCCAAGCA taccanqgtt ATCCTCCTGT CNCTNGGGTG TCCCAAANTT CCNTANGGCG

AACCACCATA TGCTCTCCTT aatggatgcg AAGCNTCCGG TTGCTGCAOC TGGAAGGGCC CCCCGACAGG NCCTCCAKCA GGGGAAANAA CTTGCTTGGG GTCTGAAACT CCCCTNGNTT

GGTAAAGCGG QCAGAGTCCT CTGGAGCTCG GCAGTTGGGG GGAACTGGGT TGGGGOAAAT CTAGAAATGC AACCAAAANC ACCCGGCNGN TGGAANAGCA AATCACCGTC TGGGTNNTTT ooooooooooooo 6284062 S40626 1123344S6677 (Please read the note on the reverse side and the sequence on this page). • Sequence: A) • Length: 724 base pairs (B) Type (C) Stranded nucleic acid Single strand (D) Topology: Straight line (ii) Molecular type: cDNA (xi) Sequence description: Sequence identification number 38

τττττττττττ CTTCCNAAAT CAAATTAATT AATT 'CTT; NGATTT, TCCTNTTj TTTTTGAATT CCCNCTTTCG AAAAAACTCC TTTNTOGGGG NGNNTTTGGT GCCG ITTAACCC rAAATCCC TAAAC ΓΤΑΑΝ

τττττττττττ TGTCCAACCC TTGGANTTTA ATTATNAACT TCCGAAAfTQ CCCCTTNANT CNTNGGTAAC GGAAATTCCN GGGfTTGGGN CAAGNNTTAA CCNGGCANTT TTTTGQGCCC

ΤΤΤΤΤΤΤΤΤΤ TXTTTi CCTCNNCCAA ATNNCCATTT AATTAAATNT TNATTNGGGG TAAATNCCTN GAAACCCNTG NTAANGGAAA ACCAAATTCN TNTTTTNACC CNNGNCTNAA TCCGGNTAAT OAANNKGCCT NCTGACCNA CCGCGGTTTT NTAGGTTGAACC TCCTTCC CNCC

CCCCCTCCAt TGAATGAAAA CCGGGGGGGO GTTCCAAACC aawaauccaa ATGTNAAGAA GNTTCCAAAA ATTTTTAACC CCTAAGGCTN TTTGAAGGTT NTATTTNGNT TCCGGTGTTT AANCCAATTA AACCGAATTT TCCCNTCCCCGGCCGGCCGGCCGGCCGGCCCCCC

、 1T -line 67 This paper size applies Chinese National Standard (CNS) A4 specification (210X297 mm) 1228593 A7 _________ B7 V. Description of the invention (65) (2) Information of sequence identification number 39: ⑴ Sequence characteristics: (A) Length : 751 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecular type: cDNA (xi) Sequence description: Sequence identification number 39: τττττττττττttttttgtttq ctcacattta atttttattt tgattttttt taatgctgca ¢ 0 CAACACAATA tttatttcat ttqtttcttt tatttcattt tatttgtttg ctgctgctgt 120 ΤΊΤΑΤΤΤΑΤΤ TTTACTGAAA GTGAGAGGGA ACTTTTGTGG CCTTTTTTCC TTTTTCTGTA 1B0 GGCCGCCTTA AGCTTTCTAA ATTTGGAACA TCTAAGCAAG CTGAANGCSAA AAGGGGGTTT 240 CGCAAAATCA CTCGGGGGAA NGGAAAGGTT GCTTTGTTAA TCATGCCCTA TGGTGGGTGA 3〇〇TTAACTGCTT GTACAATTAC NTTTGACTTX TAATTAATTG TGCTNAANGC TTTAATTANA 3SO CTTGGGGGTT CCCTCCCCAN ACCAACCCCN CTGACAAAAA GTGCCNGCCC TCAAATNATG 420 TCCCGGCNNT CNTTGAAACA CACNGCNGAA NGTTCTCATT NTCCCCNCNC CAGGOTAAAA 4Θ0 TGAAGGGTTA CCATNTTTAA CNCCACCTGC ACNTGOCNNN GCCTGAATCC TCNAAAANCN 54 0 CCCTCAANCN AATTNCTNNG CCCCGGTCNG GCNTNNGTCC CNCCCGGGCT CCGGGAANTN 600 CACCCCCNGA ANNCNNTNNC NAACNAAATT CCGAAAATAT TCCCNWTCNC TCAATTCCCC 660 CNNAGACTNT CCTCNNCNAN CNCAATTTTC TTTTNNTCAC GAACNCGNNC CNC NCTCTCCT

, 1T, printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs (2) Information on sequence identification number 40: (i) Sequence characteristics: (A) Length: 753 base pairs (B) Type: Nucleic acid (C) Stock type : Single strand (D) Topology: Straight line (ii) Molecular type: cDNA (xi) Sequence description: Sequence recognition number 40: GT < 3GTATTTT CTGTAAGATC AGGTGTTCCT1 CCCTCGTAOG TTTAGACGAA ACACCCTCAT 60 AGATGAAAAC CCCCCCGAGA CAGCACJCACT GCAACXGCCA AGCAGCGCGCGGCGGGGGGGCG GATGTGAGGC TCGATGTCAA 1Θ0 TGGTCTGGAA GCGOCGGCTQ TACCTGCGTA GGGGCACACC GTCAGGGGCC ACCAGGAACT 240 TCTC7UVAGTT CCAGCCAACN TCGTTGCGAC ACACCGGAGA CCAGGTGATN AGCTTGGGGT 3 00 CGGTCATAAN CGCGGTGGCG TCOTCGCTQG GAGCTGGCAG GGCCTCCCGG AGGAA-GGCNA 3 60 ATAAAAGGTG CGCCCCCCCA CCGTTCANCT CGCACTTCTC NAANACCATG ANGTTGGGCT 420 • 68- this paper scales applicable Chinese national standard (CNS) A4 size (21〇X297 mm) 1228593 A7 B7 V. Description of the invention (66)

CNAAGCCACC TTCTNCTCJAT AAANCACCCN GGANCCCATA TTCCCNCCCG TNCCCTATCT

ACCAmCC GCCCTANC

TCCGG r〇TG CCTCCTCNTT TCTCmCCAN NCCTCTGGCC GNACCCCNCN

ACTTCCTTGA GTTGCCCNON TCATCTGGGT TACTCACCNT CNTCAAAHAN TTTGTCTCAN

NOGAATTCGC ATGCCAANCA TNTTNTCCCG NCCCCCCCNT GCTTMCACNA TNT

AAATCTCTTC NCCCCAANCC GGACCNTGGT GOTfACCCANC CCTGGGTCTG

GNTCTTGGGC CCGGGGTCCT TCCTCTCAAG CTTCTANNGN CCTTCCCCCC 4B0 540 € 00 660 720 753 * Printed by the Consumer Cooperatives of the Central Bureau of Standards of the Ministry of Economic Affairs (2) Information on Sequence Identification No. 41 · Sequence Features: (A) Length: 341 base pairs ( B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecular type: cDNA (vi) Source: (A) Biology · Human (Homo sapiens) (xi) Sequence description: sequence ID 41: ACTATATCCA TCACAACAGA CATGGTTCAT CCCATAGACT TGTTGACATA GCTTCAAATG AGTGAACCCA TCGTTGATTT ATAXACATAT ATGTTCTCAG TA.TTTTGGGA GCCTTTCGAG ttctttaaac cttgttcatt atgaacactg aaaataggaa TTTGTGAAQA gttaaaaagt TATAGCTTGT TTA.CGTAGTA AGTTTtTGAA GTCTACATTC AA.TCCAOACA CTTAGTTGAG tgttaaactg (2) SEQ ID tgatttttaa aaaatatcat ttgagaatat tctttcagag gtattttcat TTTTAGTTTT TGATTAATTG TGTTTTATAT ATTAGGGTAG T Information of No. 42: (i) Sequence characteristics: (A) Length: 101 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecular type: eDNA ( vi) Source: $ 0 120 180 240 300 341 (Please read the (Notes on this page) Binding, binding-line-69- This paper size applies Chinese National Standard (CNS) A4 specification (21 × 297 mm) 1228593 A7 B7 V. Description of invention (67) (A) Biological: human ( xi) Sequence description ·· Sequence identification number 42: acttactgaa tttagttctg tgctcttcct tatttagtgt TGTATCATAA ATAGTTTGAT 60 GTTTCAAACA TTCTi \ AATAA. ATAATTTTCA GTGGCTTCAT A 101 (2) Information of sequence identification 43: ⑴ Sequence characteristics: (A) Length: 305 bases Pair (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecular type: cDNA (vi) Source: (A) Organism: Human (xi) Sequence description: Sequence identification number 43 : ACATCTTTOT TACAGTCTAA GATGTGTTCT TAAATCACCA TTCCTTCCTG GTCCTCACCC 60 TCCAGGGTGG TCTCACACTG TAATTAGAGC TATTGAGGAO TCTTTACAGC AAATTAAGAT 12. TCAQATGCCT TGCTAAGTCT AGAGTTCTAG AGTTATGTTT CAGAAAOTCT AAGAAACCCA 180 GCTCTTGAQA GGTCAGTAAA GAGGACTTAA TATTTCATAT CTACAAAATG ACCACAGGAT 240 TGGATACAGA ACGAGAGTTA TCCTGGATAA CTCAGAGCTG AGTACCTGCC CGGGGC3 Please read this page on the back of the page. TGGGGC3

.Institute Consumer Cooperatives of the Central Bureau of Standards of the Ministry of Economic Affairs

(2) Information of sequence identification number 44: (i) Sequence characteristics: (A) Length: 852 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecular type: cDNA -70- This paper size applies Chinese National Standard (CNS) A4 specification (210X297 mm) 1228593 A7 B7 V. Description of invention (68) (νί) Source: (Α) Biology: Human (xi) sequence description ·· SEQ ID NO 44; ACATAAATAT CAGAGAAAAG TAGTCTTTGA AATATTTACG TCGAGGAGTT CTTTGTTTCT 60 GATTATTTGG TGTGTGTTTT GGTTTGTGTC CAAAGTATTG GCAGCTTCAG TTTTCATTTT 120 CTCTCCATCC TCGGGCATTC TTCCCAAATT TATATACCAG TCTTCGTCCA TCGACACGCT 180 CGAOAATTTC TCTTTTGTAa TAATATCTCA TAGCTCGGCT GAGCTTTTCA TAGOTCATOC 240 TCCTGTTGTT CTTCTTTTTA CCCCATAGCT GAGGCACTGC CTCTGATTTC AAGAACCTGA 300 AGACGCCCTC AGAXCGGTCT TCCCATTTTA TTAATCCTGG GTTCTTGTCT GGGTTCAAGA 360 GGATGTCGCG GATGAATTCC CATAAGTGAG TCCCTCTCGG GTTGTGCTTT TTGGTGTGGC 420 ACTTGGCAGG GGGGTCTTGC TCCTTTTTCA TATCAGGTGA CTCTGCAACA GGAAGGTGAC 460 TGGTGGTTOT CATGGAGATC TGAGCCCGGC AGAAAGTTTT GCTGTCCAAC AAATCTACT CATA GTTGGTGTCA TATAAATAGT TCTNGTCTTT CCAGGTGTTC ATGATGGAAG 600 GCTCAGTTTG TTCAGTCTTG ACAATOACAT TGTGTGTGGA CTC ^ GAACAGG TCACTACTGC 660 ACTGGCCGTT CCACTTCAGA TGCTGCAAGT TGCTGTAGAG GAGNTOCCCC GCCGTCCCTG 720 CCGCCCGGOT GAACTCCTGC AAACTCATGC TGCAAAGGTO CTGGCCGTTG ATGTCGAACT 780 CNTGGAAAGG GATACAATTG GCATCCAGCT GGTTGGTGTO CAGGAGGTGA TGGAGCCACT 840 CCCACACCTG GT 852 (Please read the notes on the back of this again Printed by the Consumers' Cooperative of the Central Bureau of Standards and Quarantine of the Ministry of Economic Affairs (2) Information on Sequence Identification No. 45: (i) Sequence characteristics: (A) Length: 234 base pairs (B) Type: Nucleic acid (C ) Stock type: Single strand (D) Topology: Straight line (ii) Molecular type: cDNA (vi) Source: (A) Biology · Human (xi) Sequence description: Sequence identification number 45; ACAACAGACC CTTGCTCGCT AACGACCTCA TGCTCATCAA GTTGGACGAA TCCGTGTCCG 60 AGTCTGACAC CATCCGOAGC ATCAGCATTQ CTTCGCAGTO CCCTACCGCG GGGAACTCTT 120 GCCTCGTTTC TGGCTCGGGT CTGCTGGCOA ACGGCAOAAT GCCTACCGTG CTGCAGTGCG 180 TGAACGTGTC GGTGQTGTCT GAGOAGGTCT GCAGTAAGCfT CTATGACCCG CTGT2 Information of No. 46: (i) Sequence characteristics: (A) Length; 590 base pairs -71 * This paper size applies the Chinese National Standard (CNS) A4 specification (210X297 mm) Order-line 1228593 A7 B7 V. Invention Explanation (69) (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecular type: cDNA (vi) Source: (A) Biology: Human (xi) Sequence description: Sequence Identification number 46:

ACTTTTTATT ATTTGATAGC AAGAAOATAA TGANTATAAC aaagctttca CAGGATAAAN TTACAATGGC TGGTCTCTAA GGCTCCTGTT GGCTTGCTTT

TAAATQTTTA AATATTTTCG TATATTCCAA. TAATTGACAA AAANAAANAA AACTGAAGGG TTAAA.TGCAN TCTGCCTTAC ATATCCACAA GAGOAGACTT

TAAOGCAOAT AGATTACAGA GCANATACAA TGGAAAATCA TTATTGCAGT CANAAAGAAT ggaaaaagca tctttgggtg TCCCAGCAOG CATCTCACTG

CTATGAGAAT GTTTTAGTAA AATATCTAAT ATtTTAATGT CTANTTAATT TAATtTTCAC GTGGAAGTAG TGGCTTTGAT AAGATGAAGG GCCAACACTC

\ GAAAAC: CAATTA

GATAGj TTAC 丨 aAAAQATCAA GAATTGCAOA CAAACAGTGT TTCATGTAA'C GGAAGTANTC CGTCTGGAGA GATGAAAAAG ACTCACATGT

ATGGTGTGTA CACAGTTAAA ggcaggaaaa ttatccttta TA2VATGGTAT NCACCCANAT aaggtctttc CAGCTGCCAG GACACATGCT 60 120 180 240 300 360 420 480 540 S90 (Please read the precautions on the back before this page)

, 1T, printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs (2) Information on Sequence Identification No. 47: (i) Sequence characteristics: (A) Length: 774 base pairs (B) Type: Nucleic acid (C) Stock type : Single strand (D) topology: straight line (ii) molecular type: cDNA (vi) source: (A) organism: human (xi) sequence description: sequence identification number 47: ACAACSGGGGC AtAATGAAGG AC3TGGGQANA GATTTTAAAG AAGGAAAAAA TQAACAOAAT TTTCiCTGilAG AA.CGGGGCTT CAAAATAATT TTCTTGQGGA CCTTCACTGG TTGAAACTTA AATGGATGTQ GGACANAATT TTGTGTAATG CATTACAGAC GGGAGTCTGG GAOQAAGGAT AAACAGAAAG GGGACAAAGG AA.CATCAAAG AAAGGAAGGT GGCOTCATAC CTCCCAGCCT ACACAGTTCT CCTCATCCCT GGAGGACGAC AGTGGAGGAA CAACTGACCA TGTCGCCAGG CTGOCTCCTG GTGTTCAGCC CCCAGCTCTC GAAGCCCACC CTCTGCTGAT CCACACTCCT tgaacacaca tccccaggtt atattcctgg acatgqctga

AACGAGGCCC GGTTCAAGAC ACCCTGAGCG CTAATCCCAA CCAGCQCTCT CTCCTGTGTG cctgcgtggc ACCTCCTATT

60 120 ie〇240 300 360 420 4BO line 72- This paper size applies to Chinese National Standard (CNS) A4 (210X297 mm) 1228593 kl B7, printed by the Consumer Cooperatives of the Central Bureau of Standards of the Ministry of Economic Affairs 5. Description of the invention (70) CCTACTTCCG AC5AT0CCTTG CTGCCTGCAG CCTGTCA7 ^ AA TCCCACTCAG CCTCCAAAOC 540 acggcatggg aagcctttci1 gacttgcctg attactccag catcttggaa CAATCCCTGA 6ΰ0 TTCCCCACTC CTTAGAGGCA AG? lTAGGGTG GTTAAGAGTA GGGGTGGACC ACTTGGAGCC ^ 60 AGGCTGCTGG CTTCAA ^ TTN TGGCTCATTT ACGAGCTATG GGACCTTGGG CAAGTNATCT 720 TCACTTCTAT GGGCNTCATT TTGTTCTACC TGCAAAATGG GGGATAATAA TAGT 774 (2) SEQ ID No. 48 of the Information: (i) Sequence characteristics: (A) Length · 124 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology · Straight line (ii) Molecular type: cDNA (vi ) Source: (A) Biology: Human (xi) Sequence description: Sequence identification number 48: CANAAATTGA. AATTTTATAA AAAGQCATTT TTCTCTTATA TCCATAAAAT GATATAiiTTT 60 TTGCAANTAT ANTUU ^ TGTGT CATAAATTAT AiVTGTTCCTT AATTACAGGT CAACGCAACT 120 TGGT… serial number: 49 (2) sequence Signs: (A) Length: 147 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecular type: cDNA (vi) Source: (A) Organism: Ren-73- This paper size applies to China National Standard (CNS) A4 (210X297 mm) (Please read the precautions on the back before binding and binding 1228593 A7 B7. Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs V. Description of the invention (71) (xi) Sequence description: Sequence identification number 49: GCCGATGCTA CTATTTTATT GCAGGAGGTG GGGGTGTTTT TATTATTCTC TCAACAGCTT 60 TGTGGCTACA GGTGGTXSTCT GACTGCATNA AAAANTTTTT TACGGGTGAt TGCAAAAATT 120 ttagggcacc catat cccag 50 sequence: (A) Length: 107 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecular type: cDNA (vi) Source; (A) Organism: Human ( xi) Sequence description: Sequence identification number 50: ACATTAAATT aataaaagca ctottgggct tctgctaaaa cacatggctt gatatattgc so ATGGTTTGAO GTTAGGAGGA GTTAGGCATA TGTTTTGGGA GAGGGGT 107 (2) Information of sequence identification number 51: Sequence Column characteristics: (A) Length: 204 base pairs (B) Type: Nucleic acid (C) Strand type · Single strand (D) Topology: Straight line (ii) Molecular type: cDNA (vi) Source: (A) Biology ·· Human-74- This paper size applies to Chinese National Standard (CNS) A4 (210X297 mm) (Please read the precautions on the back before this page)

, 1T 1228593 ΑΊ B7 five described (72) (χί) Sequence description of the invention: SEQ ID NO 51: GTCCTAGGAA gtctagggga cacacgactc tgoggtgacg gggccgacac acttgcacgg eo CGGGAAGGAA AGGCAGAGAA GTGACACCGT CAGGGGGAAA TGACAGAA ^ G GAAAATCAAG 120 GCCTTGCAAG GTCAGAAAGG GGACTCAGGG CTTCCACCAC AGCCCTGCCC CACTTGGCCA 180 CCTCCCTTTT gggaccagca ATGT 204 (2) Information on sequence identification number 52. · Sequence characteristics.- (A) Length: 491 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecular type: cDNA (vi) Source: (A) Biology · Human (xi) Sequence description: Sequence identification number 52: ACAAAGATAA CATTTATCTT ATAACAAAAA TTTGATAGTT TTAAAGGTTA GTATTGTGTA 60 GGGTATTTTC CAAAAGACTA AAGAGATAACAC CTTCAGACA GTTCAGACA CTTTTGTTCA AAATGACTGA CTTAANTATT TTTAAATATT 240 TCANAAACAO TTCCTCAAAA ATTTTCAANA TGGTAGCTTT CANATGTNCC CTCAGTCCCA 300 ATGTTGCTCA GATAAATAAA TCTCGTGAGA ACTTACCACC CACCACAAGC TTTCTGOGGC 360 ATGCAACAGT GTCTTTTCTT TNCTTTTTCT TTTTTTTTTT TTACAGGCAC AGAAA.CTCAT '420 CAATTTTATT TGGA.TAA.CAA AGGGTCTCCA AATTATATTG AAAAATAAAT CCAAGTTAAT 480 ATCACTCTTG T 491 (2) Information on serial identification number 53:, Printed by the Central Government Bureau of the Ministry of Economic Affairs, Consumer Consumption Cooperative Association i : (A) Length: 484 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line

(ii) Molecular type: cDNA -75- This paper is applicable to the Chinese standard i: Standard (CNS) A4 specification (210X297 mm 1 1228593 A7 B7 V. Description of the invention (73) (vi) Source: (A) Biology: Human (xi) sequence description: Sequence identification number 53:

ΓΑΑΤΤΤ rTAACAC

GTATTAACAG ACTACAGAAC CAATCAAATC GCACTAGTAT AGCTTTGANT AATGATTGGC TANCTTGANT CANT GCAGOGCTAA TTACCATAAG A.TGCTATTTA TTAANAGQTN TATGATCTGA TTGCTGAAGT TTGC3TATTTT TATGCAGCAT TTTCTTTTTG CTTTGATAAC CCTTAAGGAC ACTGAAAATT agtaagtaaa gttcagaaac ATTAGCTGCT TCTACATAAC ACTATAGTAA TTAAAACGTT AAAAAAAAGT GTTGAAATCT ANACCGCTCC TGTCAGGATA ANACTGCTTT GGAACAGAAA GGGAAAAANC ttgtttgtgc tgatangagg 'aaaggctgaa ttaccttgtt gcctctccct AGGTCNGGTA AATNCCAAAA CATATTCCAA CTCAACACTT CTTTTCCNCG CTGTQTATTC caggancagg cggatggaat gggccagccc ngggatgttc ¢ 0 120 180 240 300 360 420 480 4Θ4 (2) Information for sequence identification number 54: ⑴ Sequence characteristics: (A) Length: 151 test pairs (B) Type: Nucleic acid (C) Share type: Single strand ( D) Topology ·· Straight line (ii) Molecular type: CDNA (vi) Source: (A) Biology: Human (xi) Sequence description: Sequence identification number 54: Read first-Read the back-Precautions Printed by CCAGTGGGTA TACTGCTGAC AACCGCAACA Μ TCTATGTCCT CTCAAGTGCC TTTTTGTTTG TT (2) Serial Identification Information of No. 55: ⑴ Sequence characteristics: (Α) Length: 91 base pairs (B) Type: Nucleic acid; aaaacggtg ccatco .CAAAAACAC AAATCC '

： TTGG CACTGGCTAG 60 120 1S1 -76- This paper size is applicable to Chinese national standard (€ milk) 8 4 size (210 '乂 297 mm) 1228593 Printed by A7 B7 of the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs (74) (C) Strand type: Single strand (D) Topology: Linear molecule type: cDNA (vi) Source: (A) Biology: Human (xi) Sequence description, sequence identification number 55: ACCTGGCTTG TCTCCGGGTG GTTCCCGGCG GCCCCCACGG TCCCGAGAAC GGACACTTTC GO GCCCTCCAGT GGATACTCGA GCCAAAGTGG T (2) Sequence identification number 56: (i) Sequence characteristics: (A) Length: 133 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology : Straight line (ii) molecular type: cDNA (vi) source: (A) organism: human (xi) sequence description: sequence identification number 56: GGCGGATGTG CGTTGGXTAT ATACAAATAT GTCATTTTAT GTAAGGGACT TGAQTATACT 60 TGGATTTTTQ GTATCTGTGG GTTGGGGGGA CGGTCCAGGA ACOAATACC TOCA CATGG 3 2) Information on Sequence Identification No. 57: ⑴ Sequence characteristics: (A) Length: 147 base pairs (B) Type: Nucleic acid-77- This paper is in accordance with China National Standard (CNS) A4 ^ _ (210X 297 mm) (Read the precautions on the back of this page-installation, \ 呑 线 1228593 A7 B7, printed by the staff of the Central Procurement Bureau of the Ministry of Economic Affairs, consumer cooperation, printed 5. Invention Description (75) ( C) Stock type: Single strand (D) Topology: Straight line (ii) Molecular type: CDNA (vi) Source: (A) Biology: Human (xi) Sequence description: Sequence identification 57: ACTGTQGAGA ACCTGAGCCG CTGCTCCGCC TCTGGGATGA GGTGATCkJAN GCNGTGGCGC gactgggagcc tgagcccttc cctttgcgcc tgcctcagao gattgttqcc gacntgcana TCTCAN ^ GGG GTGGA.TNCAT GCAGGGT (2) Sequence identification number 58: ⑴Sequence features: (A) Length: I98 base pairs (B) Type: Nucleic acid (C) Share type ·· Single (D) Topology: Straight line (ii) Divided type: cDNA (vi) Source: (A) Organism: Human (xi) Sequence description: Sequence identification number 58: ACAGGGATAT AGGTTTNAAa TTATTGTNAt TGTAAAATAC ATTGAATTTT CTGTATACTC TGATTACATA CATTTATCCT TTCATAAAGA TGTAAATCTT AATTTTA ATTTACCAAT GAGTTACCTT GTAAATGAGA AGTCATGATA GCACTGAATT TTAA.CTAGTT TTGACTTCTA AQTTTGGT (2) Information of sequence identification number 59: ⑴ Sequence characteristics: (A) long : 330 base pairs (B) TYPE: nucleic acid 60,120,147

60 120 ieo19B (Please read the precautions on the back page first) -Installation ·-= " Line -78- This paper size is applicable to China National Standard (CNS) A4 gauge (210X297 mm) 1228593 A7 B7 V. Description of the invention (76) (C) Strand type: single strand (D) Topology: straight line (ii) Molecular type: cDNA (vi) Source: (A) Biology: human (xi) Sequence description: Sequence identification number 59: ACAACAAATG GGTTGTGAGQ AAGTCTTATC AGCAAAACTG GTGATGGCTA CTGAAAAGAT 60 CCATTGAAAA TTATCATTAA TGATTTTAT ^ A TGACAAGTTA TCAAAAACTC ACTCAATTTT 120 CACCTGTGCT AGCTTGCTAA AATGGOAGTT AACTCTAGAO CAAATATAOT ATCTTCTGAA 180 TACAGTCAAT AAATOACAAA GCCAGGGCCT ACAGGTGGTT TCCAGACTTT CCAGACCCAG 240 CAGAAGGAAT CTATTTTATC ACATGGATCT CCOTCTGTGC TCAAAATACC t ^ ATGATATT 300 TTTCGTCTTT ATTGGACTTC TTTGAAGAGT 330 (2) SEQ ID NO 60, Information: ⑴ Sequence characteristics: (A) Length: 175 base pairs (B) Type: Nucleic acid (C) Strand type · Single strand (P) Topology: Straight line (ii) Molecular type: cDNA (vi) Source: (A) Biology: human, printed by the Central Laboratories of the Ministry of Economic Affairs, Consumer Cooperatives (xi) Sequence description: Column identification number 60: ACCX3TGGGTO CCTTGTACAT TCCTGACGGC TCCTTCACOA ACATCTGGTT CTACTTCGGC 60 GTCGTGGGCT CCTTCCTCTT CATCCTCATC CAGCTGGTGC TGCXCATCGA CTTTGCGCAC 120 TCCTGGA · AGIDGTIDCT sequence: Base pairs -79-This paper size applies Chinese National Standard (CNS) A4 specification (210X297 mm) 1228593 A7 V. Description of the invention (77) (B) Type: Nucleic acid (C) Stock type: Single strand (D) Topology ·· Straight line (ii) Molecular type: cDNA (vi) Source: (A) Biology: Human (xi) Sequence description: Sequence identification number 61: ACCCCACTTT TGCTCCTGTG AGCAGTCTGG ACTTCTCACT GCTACATCAT GAGGOTGAGT GGTTGTTGCT OTTCAACAGT ATCCTCGCCT TTCCGGATCT GCTGAGCCCCGGGGCCCCACTG CTGT l-54 (2) Information for sequence identification number 62: ⑴ Sequence characteristics: (A) Length · 30 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecular type: CDNA (vi) Source: (A) Organism; Human (xi) Sequence description: Sequence recognition 62 : Printed by CGCTCQAGCC, CTATAGTOAG, TCGTATTAGA 30, printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs. (2) Information on sequence identification number 63. ⑴ Sequence characteristics: (A) Length: 89 base pairs (B) Type: Nucleic acid-80- Paper size applies Chinese National Standards (CNS) A4 regulations (210X 297 mm) 1228593 A7 B7, printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs 5. Description of the invention (78) (C) Stock type ·· Single stock (D ) Topology: straight line (ii) molecular type: cDNA (vi) source: (A) organism: human (xi) sequence description: sequence identification number 63: ACAAGTCATT TCAGCACCCT TTGCTCTTCA AAACTGACCA TCTTTTATAT TTAATGCTTC 60 CTGTATGAAT AAAAATGQTT ATGTCAAGT 89 (2) sequence recognition Information of No. 64: ⑴ Sequence characteristics: (A) Length: 97 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecular type: cDNA (vi) Source: (A) Biology: Human (xi) Sequence description: Sequence identification number 64: ACCGGAOTAA CTGAGTCGGG ACGCTGAATC TGAATCCACC ΑΑΤΑΑΑΤΑ7Λ GGTTCTGCAG € 0 AATCAQTGCA TCCAGGATTG GTCCTTGGAT CTGGGGT "(2) Sequence ID 65 News: (i) Sequence characteristics: (A) Length: 377 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology ·· Straight-81-This paper applies Chinese national standards (CNS) A4 specification (210X 297 mm) (Please read the precautions on the back v. Installation-F this page)-'口 线 1228593 A7 ΒΊ V. Description of the invention (79

(ii) Molecular type: cDNA (vi) Source: (A) Organism: human (xi) Sequence description: Sequence recognition ACAACAANAA NTCCCTTCTT TAGGCCACTG GCATCOCQTC CTAGGCCTTG ACACAGCGGC CCAACCCTGG TCTACCCACA NTTCTGGCTACATTCCGCGGTGCGGGGtgggggctgtctgctgctgctgctgctgctgctgctgctgctgctgctgctgctgctggt

No. 65: ATGGAAACCT TGGGOTTTGG TGGGCTGTCT AGAGGTCAGT CCTGGCATTC GCCTGGGCOA

GGAACCCCCT GCTNTCCCAA CTOCCACTGA AGAGGAAGCT GCCGCTGAAC TGCAANGGTG

TTTGATGGCA ACCGCACACG ACATCAGGGT CAATGAGAAA TATGAACCCG CGAACAGGAG 60 120 180 240 300 360 377 (Please read the notes on the back first (2) Information on sequence identification number 66: (i) Sequence characteristics: (A) Length: 305 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecular type: cDNA (vi) Source: (A) Biology: Human (xi) Sequence description · Sequence identification page 66) • Packing · Order-line * Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs

ACGCCTTTCC AGAACCCGTQ AGGAACTAAC TCCTCCACTC TTATATATTT

CTCAGAATTC TGCCCCTTCC TCJCACCCTGG TAAGGGATAT TTTAATAAGA

AGGGAAGAGA CACCATATCC TCCTCTCCCG CAACACTGCC TGCACTTTAT CTGTCGCQTG ACCCTCGCTC AOTCCCCAGT CAGCACAGGG gtoatttttt

ccttcctccg catctttgaa TCACCCTCCA CCCCTGAATT AATAAAGTCT

TTGTTGCGTG CTCAAACACG TCCCTCACCT TATGTGGTTT GAAGAATTAC 60 120 1Θ0 240 300 305 (2) Information of sequence identification number 67: ⑴ Sequence characteristics: (A) Length: 385 base pairs (B) Type: Nucleic acid 82 This paper is in accordance with Chinese national standards ( CNS) A4 specification (210X 297 mm) 1228593 A7 B7 * Printed by the Consumer Cooperatives of the Central Government Bureau of the Ministry of Economic Affairs. 5. Description of the invention (80) (C) Stock type: Single stock (D) Topology ·· Straight line ( ii) Molecular type: cDNA (vi) Source: (A) Biology: Human (xi) Sequence description: Sequence recognition ACTCACACA CTCCACTTGG CCTTGTGAGA GGTCGGAGCA GCCACATCTC ATGTGCAAGA CCCTTTTAAA AAAGGGGACT TGCTTAAAAA TGTOCTGTGCCC TGGAOATTCA CTTTTGA ^ AG CTGCGCAGGC TCGCA TTGCA 2) Information on sequence identification number 68 (i) Sequence characteristics: (A) Length: 73 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecular type: cDNA (vi) Source: (A) Organism: human (xi) Sequence description: Sequence identification number 68: ACTTAACCAG ATATAXTTTT ACCCCAGATG GGGATATTCT TTGT AAAAAA TGAAAATAAA GTTTTTTTAA tg〇 (2) Information of sequence identification number 69: ⑴ Sequence characteristics: (A) Length: 536 base pairs (B) Type: Nucleic acid

No. 67: CACTTTGTCC TTGCCCAGCA AGAAGTCTAG AGTTCTCCTC GTGTGATCTC TGGTTACAGG

CAGCACTTTiV GACATCAGGT CCACGATTGT TGAGACCTGA AGCACTCCTT GCACTCTCAO

GGAATGCTGA CTGAGAGTTC GTAGAGCAGC TCTTTAGAGG AGTCTGCTTG ATGCCCATAC 60 120 180 240 3 00 360 385 60 73 Please read the back first. Notices Binding on this page -83 This paper size applies to the Chinese National Standard (CNS) Α4 size (210 × 297 mm) 1228593 A7 B7 V. Description of the invention (81) (C) Strand type ·· Single strand (D) Topology: straight line (ii) Molecular type: cDNA (vi) Source: (A) Biology: human (xi) Sequence description: sequence ID 69: ACTAOTCCAG TGTGGTGGAA TTCCATTGTG TTGGGGGCTC TCACCGTCCT CTCCTGCACC 60 TCCAGCTTTG TGCTCTGCCT CTGAGGAGAC CATGGCCCA.G CATCTGAGTA CCCTGCTGCT 120 CCTGCTGGCC ACCCTAGCTG TGGCCCTGGC CTGGAGCCCC AAGGAGGAGG ATAGGATAAT 18 0 CCCGGGTGGC ATCTATAACG CAQACCTCAA TOATGAGTGG GTACAGGGTG CCCTTCACTT 240 CGCCATCAGC GAGTATAACA AGGCCACGAA AGATGACTAC TACAGACGTC CGCTGCGGGT 300 ACTAAGAGCC AGGCAACAGA CGGTTGGGGG CGTGAATTAC TTCTTCGACG TAGAGGTGGG 3 60 CCGAACCATA TGTACCAAGT CCCAGCCCAA OTTGGACACC TGTGCCTTCC ATGAACAGCC 420 AGAAGTGCAG AAGAAACAGT TGTGCTCTTT CGAGATCTAC GAAGTTCCCT GGGGAGAACA 480 GAANGTCCCT GGGTGA AATC CAGGTGTCAA. GAAATCCTAN GOATCTGTTG CCAGGC 536 (Please read the notes on the back before this page) • Equipment-• Printed by the Consumers' Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs (2) Information on Serial Identification No. 70: (i) Sequence Features ·· (A) Length: 477 base pairs (B) Type: Nucleic acid (C) Strand type · Single strand (D) Topology: Straight line (ii) Molecular type: cDNA (vi) Source: (A) Biology: Human (xi) sequence Description: SEQ ID NO 70:. ATGACCCCTA ACAGGGGCCC TCXCAGCCCT CCTAATGAGC TCCGGCCTAO CCAXGTGATT 60 TCACTTCCAC TCCATAACGC TCCTCATAGT AGGCCTACTA ACCAACACAC TAACCATATA 120 CCAATQATGG CGCGATQTAA CACGAGAAAG CACATACCAA GGCGJVGCACA CACCACCTGT 180 CCAAAAAGGC CTTCGATACG GGATAATCCt ATTTATTACC TCAGAAOTTT TTTTCTTCGC 240 AGGGATTTTT CTGAGCCTTT TACCACTCCA GCCTAGCCCC TACCCCCCAA CTAGQAGGGC 3〇〇ACTGGCCCCC AACAGGCATC ACCCCGCTAA. ATCCCCTAGA AGTCCCACtC CTAAACACAT 360 CCGTATTACT CGCATCAGGA GTATCAATCA CCTGAGCTCA CCATAGTCTA ATAGAAAACA 420 ACCGAAACCA AATTATTCAA AQCACTGCTT ATTACAATTT TACTGGGTCT CTATTTT 477 -84-China paper standard Standard (CNS) A4 size (210X297 mm)

1T 1228593 A7 B7 V. Description of the invention (82) (2) Information of sequence identification number 71: ⑴ Sequence characteristics: (A) Length: 533 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: straight line (ii) Molecular type: cDNA (vi) Source: (A) Organism: human (xi) Sequence description: Sequence identification 71: AGAGCTATAG GtACAGTGTG ATCTCAGCTT TGCAAACACA TTTTCTACAT AGATAGTACT 60 AGGTATTAAT AGATATGTAA AGAAAOAAAT CACACCATTA ATAATGOTAA GATT TGTGATTTTA GTGGTATTTT TGdCACCCTT ATATATOTTT TCCAAACTTT CAGCAGTGAT 1B0 ATTATTTCCA TAACTTAAAA AGTGAGTTTG AAAMGAAAA TCTCCAGCAA GCATCTCATT 240 TAAATAAAGG TTTGTCATCT TTAAAAATAC AGCAATATGT GACTTTTTAA AAAAGCTGTC 300 AAATAGGTGT GACCGTACTA ATAATTATTA GAAATACArT TAAAAACATC GAGTACCTCA 3 ^ 0 AGTCAGTTTG CCTTGAAAAA TATCAAATAT AACTCTTAGA GAAATGTACA TAAAAGAATG 420 CTTCOTAATT TTGGAGTANG AGCTTCCCTG CTCAATTTTG TATTTTXAAA AAGTACAtGG 4Θ0 ΤΑΆΑΑΑΑΑΑΑ AATTCACAAC AOTATATAAG GCTGTAAAAT GAAGAATTCT GCC 533 (Please read the precautions on the back before UPr page).

, 1T, printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs (2) Serial ID No. 72: ⑴ Sequence characteristics: (A) Length: 511 base pairs (B) Type: Nucleic acid (C) Stock type: Single Unit (D) Topology: Straight line (ii) Molecular type: cDNA (vi) Source: (A) Biology: Human (xi) Sequence description: Sequence identification number 72: -85--The paper size of the paper applies Chinese national standards ( CNS) A4 specification (210X297 mm) 1228593 A7 B7 V. Description of the invention (83

TATTACGGAA AAATGAAAGG AAGCCGCAOG AAACA.TGGAN GAGGTTCTCT CACATGAGAA GCTTCTAGGO ATTTCTCTCC: AAATACACCC

AAACACACCA CTTCCAGGCA ATGTCTACAC AGATTGGTGC GTGTGCCCAC CTGAAATGGC ACAATAACCG ATTGCAGCNA CCTCTTGAAG CATAATTCAA CTANCAAAOA ANACTGCTTC AGGGCGTGTA 60 GTTATCTGAT TAAAGAACAC TACGATCAGGTACTAGAGCAGTACGAGGAG TGGTTTGAAA ACCGTTCTNC iU \ TAATGATA GAATAGTACA 300 CCAAACCCAG AAAGAAAGCC CAACTAGATC CTCAGAANAC 360 ATGAAGAAAA CATGGCCTCC TTGTGCCCCC OTCTGTTATO ^ 20 NAAACCCGTT CTTCTAAGCA ACANCAGGTG ATGATGGCNGG Standards 480 NAC employee identification 480ACC ) Sequence characteristics ... (A) Length: 499 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecular type: cDNA (vi) Source ... (( A) biological: human (xi) sequence Description: SEQ ID NO 73: CAGTGCCAGC ACTGGTGCCA GTACCAGTAC CAATAACAGT CAGTGGTGGC TTCAGTGCTG GTGCCAGCCT GACCGCCACT TGGCCTTGGT GGAGCTGGTG CCAGCACCAG TGGCAGCTCT CAAGTGAGAT TTTAGATATT GTTAATCCTG CCAGTCTTTC CTCAGAAACC TACTCAACAC AGCACTCTAG GCAGCCACTA CTCTGCATTA AATCTATTTG CCATTTCTGA AAAAAAAAAA ANTCTAGAGG GCCCGTTTAA ACCCGCTGAT CAGCCTCGAC CATCTGTTGT TTGCCCCTCC CCCGNTGCCT TCCTTGACCC GTCCTTTCCT AANTAAAAT (2) Information on sequence identification number 74 ... Sequence characteristics ... (A) Length: 537 base pairs

GCCAGTGCCA CTCACATTTG GGTGCCTGTG TCTTCAAGCC TCAATCAATT AAAAAAAGGG TGTGCCTTCT TGGAAAGTGC

GTGCCAGCAC GGCTCTTCGC GTTTCTCCTA AGGGTGCATC GAAGTTGACA CGGCCGCTCG ANTTGCCAGC CACTCCCACT 000000009 628406289 11233444 (Please read the precautions on the back first ν • Installation-F page)

1T (B) Type (C) Stranded Nucleic Acid Single Strand (D) Topology: Straight-86- This paper size applies to China National Standard (CNS) A4 (21〇X 297mm) 1228593 A7 B7 V. Invention Description (84

: ii) Molecular type: cDNA

(vi) Source: (A) Organism: Human (xi) Sequence description: Sequence TTTCATAGGA GAACACACTG TTATCAGCTT AACTCAGATA TCCAGGCCCA CGGCTCAAGT CATTGTATGC ATGGAAACAT AAAGAATTAC AGACTCTGAT GGCTTTTGAT TTATAANACT CAGTTTGCTT GATATATTTGATGAGATAGAGATAGA

Column identification number 74: AGGAGATACT TGAAGAATTT GGATTCAGCC AAATCATTGA AAGTAATAAG GTAAAAGCTA GAATTTGAAT ACTGCATTTA CAGTGTAGAG GGAGGAACAG TATTACAGTG TCCTACCACT TCTACAGTGA TAG ATTGATGA TGA ATGA ATGA ATGA ATGA

GCGAAGAGAT GTCTCTAACT TAACACATAA CTAATCAAGA TAATCATTAG TACTGCCTTC AATGGGTTCT CACTCTTGAT GTCCCGT 60 120 180 240 300 360 420 480 53 7 (2) Information on sequence identification number 75: (i) Sequence characteristics: (A) Length: 467 base pairs (B) Type: Nucleic acid (C) strand type: single strand (D) topology: straight line (ii) molecular type: cDNA (vi) source: (A) organism: human (xi) sequence description: sequence identification number 75 (please read the first (Notes on this page), printed by the Consumer Cooperatives of the Central Bureau of Standards of the Ministry of Economic Affairs

CAAANACAAT TGCATATTAC CCTGCTGTCT TGGCACAAGG TCTAGTTGGG TCATTATTGT CAATGAGGAA CTCCAGCCAA

TGTTCAAAAG ACGTACCTCC GCTTAGAAGA AGGCCATCTT CTTTCTTTCT ATAACGGTTT TAGCCACGGT CCCAAATAGC

ATGCAAATGA TCCTGCTCCT ACGGCTTTCT TTCCTCATCG GGGTTTGGGC TCAAACCNGT GATCTCCAGC CGCTGCTATN

TACACTACTG CAAGTAGTGT GCTGCAANGG GTTATTGTCC CATTTCANTT GGGCACNCAG ACCAAATCTC GTGTAGAACA

CTGCAGCTCA GGTCTATTTT AGAGi CTAGJ CTCATGTGTG AGAACCTCAC TCCATGTTNT TCCCTGN

3AAATCA 3AAGCGT

CAAACACCTC GCCATCATCA TAACAGACGG CTTCTGAGGA TACTATTCTA TCTGTAATAA TCCAGAGCTC 60 120 180 240 300 360 420 467 (2) Information of serial identification number 76 (i) Sequence characteristics: 87 This paper is applicable to China National Standard (CNS) A4 specification (210X297 mm) 1228593 A7 B7 V. Description of Invention (85

(A) Length: 400 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecular type = cDNA (vi) Source: (A) Biology: Human ( xi) sEQUENCE DESCRIPTION: SEQ ID NO 76: AAGCTGACAG CATTCGGGCC GAGATGTCTC GCTCCGTGGG CTTAGCTGTG CTCGCGCTAC TCTCTCTTTC TGGCCTGGAG GCTATCCAGC GTACTCCAAA GATTCAGGTT TACTCACGTC ATCCAGCAGA GAATGGAAAG TCAAATTTCC TGAATTGCTA TGTGTCTGGG TTTCATCCAT CCGACATTGA AGTTGACTTA CTGAAGAATG GAGAGAGAAT TGAAAAAGTG GAGCATTCAG ACTTGTCTTT CAGCAAGGAC TGGTCTTTCT ATCTCTTGTA CTACACTGAA TTCACCCCCA CTGAAAAAGA TGAGTATGCC TGCCGTGTGA ACCATGTGAC TTTGTCACAG CCCAAGATNG JAGTGGGA ΤΤΝί

TCGANACATG TAAGCAGCAN CATGGGAGGT ooooooo 6 2 8 4 0 6 0 1 1 2 3 3 4. Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs

(2) Information on sequence identification number 77: ⑴ Sequence characteristics: (Α) Length: 248 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecular type : cDNA (vi) source: (A) biological: human (xi) sequence Description: SEQ ID NO 77: CTGGAGTGCC TTGGTGTTTC AAGCCCCTGC AGGAAGCAGA ATGCACCTTC TGAGGCACCT CCAGCTGCCC CGGCGGGGGA TGCGAGGCTC GGAGCACCCT TGCCCGGCTG TGATTGCTGC CAGGCACTGT TCATCTCAGC TTTTCTGTCC CTTTGCTCCC GGCAAGCGCT TCTGCTGAAA GTTCATATCT GGAGCCTGAT GTCTTAACGA ATAAAGGTCC CATGCTCCAC CCGAAAAAAA 0 0 0 0 8 6 2 8 4 4 112 2 -88- This paper size is applicable to Chinese National Standard (CNS) A4 specification (210X297 mm) 1228593 A7 B7 V. Description of the invention (86) (2) Serial identification number 78 information: (i) Sequence characteristics: (A) Length: 201 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecular type: cDNA (vi) Source: ( A) Biology: Human (xi) Sequence Description: Sequence Identification No. 78: (Please read the note on the back page first)-Installed · Printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs 60 120 180 201 (2) Sequence identification number 79 says: (i) Preface 歹] Features: (Α) Length: 552 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology Pu Xue: straight line (ii) molecular type: cDNA (vi) source: (A) organism: human (xi) sequence description: sequence identification number 79:

ACTAGTCCAG TGTGGTGGAA TTCCATTGTG TTGGGCCCAA CACAATGGCT ACCTTTAACA TCACCCAGAC CCCGCCCTGC CCGTGCCCCA CGCTGCTGCT AACGACAGTA TGATGCTTAC TCTGCTACTC GGAAACTATT A7 7B ASC7-ATC-ATC-AAAAAAAC Invention Description (87

TCCTTTTGTT TTTAGGCAGT CCTCTTTCTT TGTGATAGTA ATGCAAGTTA CTGTTCCTTG TAATATTCTA TTCCCAGGAA CNGTTTTGGT

AGGTTTTTGA GCTAGTAATT CTGAAGATTA TAAGTATCTA GTAATTACTC GCTAGAAAAA TGTTCTAAAA TATGGGGTTC TAATACGTTA AA

GACAACCCTA TCCTCGTAAT ATGAAGTTGA AGTGCAGATG AGGGTTAACT ATTATAAACA GTTGGGCTAT ATTTATGAAT ATATGTCCTN

GACCTAAACT GATTCTGTTA AAATTGAGGT AAAGTGTGTT AAATTACTTT GGACTTTGTT ACATAAANTA ANTACCCGGG AATNAACAAG

GTGTCACAGA TTACTTTCCT GGATAAATAC ATATATATCC AATATGCTGT AGTTTGGGAA TNAAGAAATA ANAGAAGTTT GCNTGACTTA

CTTCTGAATG ATTCTTTATT AAAAAGGTAG ATTCAAAATT TGAACCTACT GCCAAATTGA TGGAATTTTA TGANTNAAAC TTTCCAAAAA 60 120 180 240 300 360 420 480 540 552. Printed by the Consumer Standards Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs (2) Information on the sequence identification number 80: ⑴ Sequence characteristics: (A) Length: 476 Base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology ·· Straight line (ii) Molecular type: cDNA (vi) Source: (A) Biology: Human (xi) Sequence description: SEQ ID NO 80: ACAGGGATTT GAGATGCTAA GGCCCCAGAG MCGTTTGAT CCAACCCTCT TATTTTCAGA G < 5GGAAAATG GGGCCTAGAA OTTACAGAGC ATCTAGCTGG TGCGCTGGCA CCCCTGGCCT cacacagact cccgaotagc tgggactaca ggcacacagt cactgaagoa ggccctgtit GCAATTCACG TTOCCACCTC CAAGTTAAAC ATTCTTCATA TGTGATGTCC TTAGTCACTA AGOTTAAACT TTCCCACCOA GAAAAGGGAA CTTAGATAAA ATCTTAGAGT ACTTTCATAC TCTTCTAAGT CCTGTTCCAG CCTCACTXTG AGTCCTCCTT GGGGGTTGAT AGGAANTNTC TCTTGGCTTT GTCAAT7 \ AAA TGTCTATCCA TCTCATGTTT AATTTGGTAG GCNTAAAAAT GCTQAAAAAA TTAAAATGTT CTGGTTTCNC TTTAAAAAAA (2) Information of sequence identification number 81: ⑴ Sequence characteristics: (A) long : 232 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight 60 120 1B0 240 300 3 60 420 476 (Please read the precautions on the back first ^^^ This page) 90 This paper size applies Chinese National Standard (CNS) A4 (210X297 mm) 1228593 A7 B7 V. Description of the invention (88) (ii) Molecular type: cDNA (vi) Source: (A) Biology: Human (xi) sequence DESCRIPTION: SEQ ID NO 81: TTTTTTTG TATGccntgn gtgtggngtt attgttgctg tcttgcactt ttgctagggt tggaggcgct ttgctggtag cccctcagag actcagtcag cggga vtaag tcctaggggt ggggcgtgtg gcaagccggc ct (2) SEQ ID information number of 82 ccaccctgga gqagcccagt ttcttctgta tctttctttt ctgggggmc ttcctggctc tgcccgtcca ttcccagcct ctcatcccca:? (i) sEQUENCE cHARACTERISTICS: ( A) Length: 383 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecular type: cDNA (vi) Source: (A) Biology: Human 60 120 1B0 232 (Please read the precautions on the back before this page) • Installation.

1T * Consumption cooperation printed by the Central Government Bureau of the Ministry of Economic Affairs (xi) Sequence description: Sequence identification number 82 AGGCGGGAGC AGAAGCTAAA GCCAAAGCCC AGTACCAGTA CCAATAACAT GCCA0TGCCA GTGCCAGCCT GACCQCCAQV CTCACATTTG CCAGCACATCCATCACTCATCCCTCCATCTCCCTCATCCC Information identifying number 83: (i) sequence characteristics: (A) length: 494 base pairs

AAGAAGAGTG 6CAGTGCCAG GTGCCAGCAC CAGTGGT6GC GGCTCTTCGC TGGCCTTGGT GTTTCTCCTA CAAGTGA ^ AT AGGGtGCATC CTCAGAAACC GAAGTTGACA CTCTGCATTA

CACTGGTGCC TTCAGTGCTG GGAGCTGGTO TTTAGATATT TACTCAACAC AATCTATTTG 60 120 180 240 300 360 383-line (B) type (C) strand type nucleic acid single strand 91

This paper size is in accordance with Chinese National Standard (CNS) A4 specification (210 × 297 mm) 1228593 A7 B7 V. Description of the invention (89) (D) Topology: straight line (ii) Molecular type: eDNA (vi) Source: (A ) Biology: Human (xi) Sequence description: Sequence recognition number 'AAGCGA TCATGTI .GAAATT TGACCCi

ACCGAATTGG GGGAGATCGA CCATCCTGGT ACGCTTCAAG ATGTCTTTTC AGCCCTOATG TATGCTTGTG TTTCNCATAT

GACCOCTGGC GTCTATACGC CGGTTCTCCC GTGCTCATGA TGCCACCTGT CCTTTTTGCC TGAGGCAATC TTTAAATTAG

TTAT · TGAA (CAGATGACAA CCCAGCAACG TACCCCTCGG AGCCATACTC A.TGGTGGCAT NACCAGAATA

1TCCTC GATG ATACTCTCOA GCGCCCTGTC AGACTCCGTA TTTGGCNTCC CACCCATNAA NTTCAGAATA

CAC3TATTACC GOACAACAGA CACCGAATCA CTCTOAGGGT ACCAAACTCT AGTCTCTCGT GGGAACACAT AATC3AATTGA

TCAACGAGCA CCTGCTCAGC CCATCAAGAA CCtTAAACTG TCGOACTGTG GGCGATTGAT TTGANTTITT AAAACTGTTA 60 120 ieo 240 300 36C 420 480 454 (Read the notes on the back first and then on this page) Installation_ (2) Information of sequence identification number 84: ⑴ Sequence characteristics: (A) Length · · 380 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecular type: cDNA (vi) Source · (A) Biology: Human (xi) sequence Note: Order No. 84, printed by the Consumer Cooperatives of the Central Government Bureau of the Ministry of Economic Affairs

GCTGGTAGCC TATGGCGTGG CCACGGAliGG GCTCCTGAGG AGTATCCTGC GCCQCGTCTT CTACCGTCCC TACCTGCAGA gaggacatgg acgtggccct catggagcag (2) identifying information sequence wherein the sequence (i) number of 85 agcaactgct gcacaccctc ctggggccca ggcgggcacc tccgtctccc GTGCTGCTCC TCOTCATCTT CCTGCTCGTG GCCAACATCC CCATGTtCAG TTACACATTC GGCAAAGTAC AGGGCAACAG AGCQTTNCCG CCTCATCCGG: -92-

CACGOGACAG TCTTCQGGCA CGTCGGAGCC agtatcccaa TGCTGaTCAC CNATCTCTAC

tgacttccca GATTCCCCAG CGGCTTCTGG CTGGCTGGTG TTGCTCATTG TGGGAAGGCC 60 120 180 240 300 360 380 This paper size applies Chinese National Standard (CNS) A4 specifications (210X297 mm) 1228593 A7 B7 V. Description of the invention (90) (A) Length: 481 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (along molecular type: eDNA (vi) Source: (A) Biology: Human (xi) Sequence description: Sequence identification number 85: GAGTTAGCTC CTCCACAACC TTGATGAGGT CGTCTGCAGT GGCCTCTCQG TTCATAGCGC 60 TNCCATCGTC ATACTGTAGG TTTGCCACCA CCTCCTGCAT CTTGOGGCGG CTAATATCCA 120 GGAAACTGTC AATCAAGTCA CCGTCNATNA AACCTGTGGC TGGTTCTGTC TTCCGCTCGG 1BO TOTGAAAGGA TCTCCAGAAQ GAGTGCTCGA TCTTCCCCAC ACTTTTGATG ACTTTATTGA 240 GfCGATTCTG CATGTCCAGC AGGAGGTTGT ACCAGCTCTC TGACAGTGAG GTCACCAGCC 300 CTATCATGCC NTTGAACGTO CCGAAGAACA CCGAGCCTTG TGTGGGGGGT GNAOTCTCAC 360 CCAGATTCTG CATTACCAGA NAGCCGTGGC AAAAGANATT GACAACTCGC CCAGGiiJNGAA 420 AAAGAACACC TCCTGGAAGT GCTNGCCGCT CCTCGTCCNT TQOTGGNNGC CCNTNCCTTT 480 τ 4Θ1 (Please read the notes on the back first \ ^ (^^ Horse page) • Binding and binding (2) Information for sequence identification number 86: ⑴ Sequence characteristics; (A) Length: 472 base pairs (B) Type: Nucleic acid (C) Stock type: Single strand, economic Printed by the Consumer Cooperatives of the Ministry of Standards and Technology (D) Topology: straight line (ii) Molecular type: cDNA (vi) Source: (A) Biology: human (xi) Sequence description: Sequence identification number 86: 11 mm ··

AACATCTTCC TGTATA ^ TGC TGTGtAATAT CGATCCGATN TTGTCTGCTG AGAATTCATT ACTXGGAAAA GCAACTTOAA GCCTGOACAC TGGTATTAiUV, ATTCACAATA TGCAAOACTT TAAACA.GTGT GTCAATCTGC TCCCTTACTT TGTCATCACC AGTCTGGGAA TAAGGGTATG CCCTATTCAC ACCTGTTAjhA agggggctaa GCATTTTTGA TTCAACATCT ttttttttga CACAAGTCCG AAAAAAGCAA AAGTAAACAG TTNTTAATTT GfTAGCCAAT TCACTTTCTT -93- This paper scales applicable Chinese National Standard (CNS) A4 size (21 OX 297 mm) 1228593 A7 B7 V. Description of the invention (91)

CATGGGACAG AGCCATTTGA TTTAAAAAGC AAATTGCATA ATATTGAGCT TtGGGAGCTG ATATNXGAGC GGAAGANTAG CCTTTCTACT TCACCAGACA CAACTCCTTT GATATTGGGA TGTTNACNAA AGTTATGTCT CTTACAGATG GGATGCTTTT GTGGCAATTC TG (2 information sequence identification sequence number: 87 sequence sequence number 87) ) Stock type: single strand (D) topology: straight line (ii) molecular type: cDNA (vi) source: (A) organism: human (xi) sequence description: sequence identification number 87; AGAAACCAGT ATGTCTNAAA ACAACCTCTC ATACCrTGTO GACCTAATTT TGTGTGCGTG TOTGTGTGCG CGCATATTAT ATAGACAGGC ACATCTTTTTT TACTTTTGTA AAAGCTTATG CCTCTTTGGT ATCTATATCT GTGAAAGTTT TAATGATCTG CCATAATGTO TTGGGGACCT TTGTGTTCTG TCTAAATGGT ACT ^ GAGAAA ACACCTATNT TATGAGTCAA TCTAGTTNGT TTTATTCGAC ATGAAGGAAA TTTCCAGATN ACKACACTNA CAAACTGTCC CTTGACTAGG GGGGACAAAG AAAAGCANAA CTGAACATNA GAAACAATTN CCTGGTGAGA AATTMCATAA ACAGAAATTTG GGTNGTATAT TGAAANAJ ^ NG CATCATTNAA ACGTTTTTTT TTT 360 420 472 (please read the back of the precautions Μ (This page) Equipment-Printed by the Staff Consumer Cooperative of the Central Bureau of Standards, Ministry of Economic Affairs 60 120 180 240 3Q0 360 413 (2) Sequence identification number 88: 诉 Sequence characteristics: (A) Length: 448 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology Pu Xue: Straight line (ii) Molecular type: cDNA (vi) Source: (A) Biology: Human paper size applies Chinese National Standard (CNS) A4 specification (210X297 mm) Order-line 1228593 A7 B7 V. Description of the invention (92 ) (xi) Sequence description: Sequence identification number 88:

CGCAGCGGGT GTCCTAGCCN CGTGCCCCTQ GGGAGGCCCA TCGGCNANTA CCCAANCAAA TTTACCAGAA GAANCANTCC

CCTCTGTATG ACCATGGCCG GCCGTGAGCC TGGACCCCGC CAACAAACCC iCTmrCCAAT TGNTCTTTTC

TTGTtAC CCNAGCC

TAGCTCCAGC GGCCCCTGCG CCGCGGCCGG GTGGAAGAAG GCAACNACTT GGGTAAN ^ AA TNGAACAATT CAAATTTT

CTCTCGCCTG CGCCCCGCTG CTCCAGTCCC AAGGTGTGCG TTACCNAGCN TTCTTGGAAG NCCCGTCCAT

CCCCACTCCC CTCCTGCTGG GGCAAGCCGC GCGTGCACTO CGCGCTGCAG TTGAACCT ^ G A ^ CAGCCCCT

CGCGTCCCGC CCATCCTGGC CGCGCCTGGT GACTTTGCCG GTTGTQCCGC GCCAAACNNG TTTAAAAAOG 60 120 180 240 300 360 420 448 (2) Information on sequence identification number 89: ⑴ Sequence characteristics: (A) Length: 463 base pairs (B) Type: Nucleic acid (C) Stock type : Single strand (D) topology: straight line (ii) molecular type · cDNA (vi) source: (A) biology · human (xi) sequence description: sequence identification number 89 GAATTTTGTG GTAGTGATTC AGAGGTCTAG CTCAGTCACA TTTNATGrm tttaacaaaa. AATTCTCTCC aattcnnana

CACTGGCCAG .TGCCAAAGTT GTCTGCATAT AGTTNNTTCT AGACTTGCCT TAGAANNACT CCATANNAAA ANTOCAGNTW

TGTGATGGAA GGTGTTGTAA CAGCAGACAG GATGCGAAGT CTNTNAAATT TCTCTGCTTN ACCCANGCCC TCATACAACA

CCATTGGGCC CATGAGTATG TTTGTCCGTO TCTNATTCCA GCTTTTGTNT: TTGA ΓΑΑΤ NAACNGGANC GAANATT1 TTGGGAUi

AGGATGGTTT TAAAATGTCA TATTTTGTAG GTGTTTTAGT TCTGCAGGTA ATATCTTACA TTGAAAAANG CCC

GAGTTTATCA aaaaattagc CCTTGAAGTT CGTTTGCATC CTATCTGTGG TCTNi GNTC

ΓΝΑΑΑΑΝΝ ITCCTTCNN 60 120 1Θ0 240 300 360 420 463 (Please read the precautions on the back and then the page). Binding and binding. Printed by the Employees' Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs (2) Serial identification number 90: (i) Sequence Features: (A) Length: 400 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand 95 The paper size is applicable to Chinese National Standard (CNS) A4 specification (210X297 mm) 1228593 A7 B7 V. Invention Explanation (93) (D) Topology ... (Straight line) (ii) Molecular type: cDNA (vi) Source: (A) Organism: Human (xi) Sequence description: Sequence identification number 90: AGGGATTGAA ggtctnttitt actqtcggac tgttcancca ccaactctac AAGTTGCTGT 60 CTTCCACTCA CTOTCTGTAA GCNTNTTAAC CCAGACTGTA TCTTCATAAA TAGAACAAAT 12 0 TCTTCACCAG TCACATCTTC TAGGACCTTT TTGGATTCAG TTAGTATAAC3 CTCTTCCACT 1δ〇TCCTTTGTTA AGACTTCATC TGGTAAAGTC TTAAGTTTTG TAGAAAGGAA TTTAATTGCT 240 CCTTCTCTAA CAATGTCCTC TCCTTGT ^ GT ATTTGGCTGA ACAACCCACC TNAAGTCCCT 30Q TTGTGCATCC ATTTTAAATA TACTTAATAG G < 3CATTGGTN cactaggtta AATTCTGCAA 3 ^ 0 GAGTCATCTG TCTGCAAAAG TTGCOTTAGT ATATCTGCCA 400 (Please read the precautions on the back f-installation-F page first) .Information for Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs of the People's Republic of China (2) Serial Identification Number 91: ： Sequence Features: (A) Length: 480 alkalis Base pair (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecular type: cDNA (vi) Source: (A) Biology: Human (xi) Sequence description: Sequence recognition 91 No: GAGGTCGGAT CCAATAATCT TTGTCTGAGG GCAGCACACA TATNCAGTGC CATGGMAA.CT 60 GGTCTACCCC ACATGGGAGG AGCATGCCGT AGNTATATAA GQTCATTCCC TGAGTCAGAC 120 ATGCCTCTTT GACTACCGTO TGCCAGTGCT GGTGATTCTC ACACACCJCC NWCCGCTCTT ISO TGTGOAAAAA CTGGCACTTG WCTGGAACTA GCAAGACATC ACTTACAAAT TCACCCACGA 240 GACACTTGAA AGGTGTJ \ ACA AAGCGACTCT TGCATTGCTT TTTGTCCCTC CGGCACCAGT 300 tGTCAATACT AACCCGCTGG TTTGCCTCCA TGACATTTGT GATCTGTAGC TCTGGATACA 360 TCTCCTGACA GTAGTOAAGA ACTTCTTCTT TTGTTTCAAA AGCAACTCTT GOTGCCTGTT 420 NGATCAGGTT CCCATTTCCC AGTCCGAATG TTCAGATGGC ATATNTTACT TCCCACAAAA 480 -96- This paper size applies to the Chinese National Standard (CNS) A4 specification (210X297 mm) Order-line 122859 3 A7 B7 V. Description of the invention (94) (2) Information on sequence identification number 92: ⑴ Sequence characteristics: (A) Length: 477 base pairs (B) Type: Nucleic acid (C) Strand type ·· Single strand ( D) Topology: straight line (ii) molecular type: cDNA (vi) source: (A) organism: human (xi) sequence description: sequence identification number 92 ATACAGCCCA NATCCCACCA CGAAGATGCG CTTGTXGACT GAGAACGTGA TGCGGTGACT SO GGTCCCGCTG T ^ GCCCCAQC GACTCTCCAC CTGCTGGCAOA CGGT TGCACTCCTf 120 CCCACGCAGG CAGGAGCGGO GCCGGTCAAT GAACTCCACT CGTGGCTTGG QGTTGACGGT 180 TAANTGCAGG AAGAGGCTGA CCACCTCGCG GTCCAGCAGG ATGGCCGACT GTGCGOGACC 240 TGCAGCQAAA CTCCTCGATG GTCATGAGCG GQAAGCGAAT GANGCCCAGG GCCTTGCCCA 300 GAACCTTCCG CCTGTTCTGT GGCGTCACCT GCAGCTGCTG CCGCTNACAC TCGGCCTCGG 360 accagcggac aaacggcgtt gaacagccgc acctcacgoa TQCCCANTGT GTCQCGCTCC 420 AGGAACGGCN CCAGCGTGTC CAGGTCAATG TCGGTGAANC CTCCOCGGGT AATGGCG 477 (back surface of the read (Notes on this page) • Equipment ·, 11 • Printed by the Consumer Cooperatives of the Central Bureau of Standards of the Ministry of Economic Affairs (2) Information of serial identification number 93: (i) Sequence characteristics: (A) Degree: 377 base pairs (B) Type: Nucleic acid (C) Strand type · Single strand (D) Topology: Straight line (ii) Molecular type: cDNA (vi) Source: (A) Biology: Human (xi) Sequence description: Sequence identification number 93: -97- This paper size applies to Chinese National Standard (CNS) A4 specification (210X297 mm)-line 1228593 A? B7 V. Description of invention (95) OAACGGCTGG ACCTTGCCTC GCATTGTGCT GCTGGGAGOA ATACCTTGGC AAGCAGCTCC ¢ 0 AGTCCGAGCA GCCCCAGAGC GCTGCCGCCC GAAGCTAAGCJ CTGCCTCTGG CCTTCCCCTC 12. CGCCTCAATG QAGAACCMTt AGTGGGAGCA CTGTGTTTAG AGTTAAGAGT GAACACTGTN 180 TGATTTTACT TGGGAAtTTC CTGTGTTATA TAGCTTTTCC CAATGCTAAT TTCCAAACAA 240 CAACAACAAA ATAACATGTT TGCCTGTTNA GTTGTATAAA AGTANOTGAT TCTGTAWTA 300 AAGAAAATAT TACTGTTACA TATACTGCTT GCAANTTCTG TATTTATTGG TNCTCTGGAA 260 ΑΤΑΑΑΤΑΤΛΤ TATTAAA 377 (2) serial number of the identification information 94: ⑴ SEQUENCE CHARACTERISTICS ·· (A) length : 495 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecular type: cDNA (vi) Source: (A) Biology · Human (xi) sequence DESCRIPTION: SEQ ID NO 94: CCGTTTGAGG GGTTAGGOTC CAQTTCCCAG TGGAAOAAAC AGGCCAGGAG AANTGCGTGC ¢ 0 CQAGCTGANG CAGATTTCCC ACAGTGACCC CAGAGCCCTG GGCTATAGTC TCTGACCCCT 120 CCAAGGAAAG ACCACCTTCT GOGGACATGQ GGTGGAGGGC AGGACCTAGA GGCACCAAGG 180 GAAGGCCCCA TTCCGGGGCT GTTCCCCGAG CAGGAAGGGA AGGGGCTCTG TGTGCCCCCC 240 ACGAGGAANA GGCCCTGANT CCTGGGATOA NACACCCCTT CACGTGTA.TC CCCACACAAA 300 TGCAAGCTCA CC2 \ AGGTCCC. CTCTCAQTCC CTTCCCTACA CCCTOAACGG NCACTGGCCC 3 60 ACACCCACCC AGMCANCCA CCC GCCATGG GGAATGTNCT CAAGGAATCG CNGGGCAACG 420 TGGACtCTNG TCCCNliAAGG GGGCAGAATC TCCAATAGAM GOANNGAACC CTTGCTNANA 480 ΑΛΑΑΑΑΑΝΑ AAAAA 495 (2) Information on Sequence Identification No. 95:, The Ministry of Economic Affairs, Central Standards Bureau, Consumer Consumption Cooperatives · Printed 472 base sequences Pair (B) Type: Nucleic Acid-(C) Strand Type: Single Strand (D) Topology: Straight -98- This paper size is applicable to Chinese National Standard (CNS) A4 (210X297 mm) 1228593 A7 B7. Central Ministry of Economic Affairs Printed by the Consumer Cooperatives of the Bureau of Standards 5. Description of the invention (96) Molecular type: cDNA (vi) Source: (A) Biology: Human (xi) Sequence description: Sequence identification number 95: GGTTACTTC3G TTTCATTGCC ACCACTTAGT GGATGTCATT TAGAACCATT TTGTGTGCTC 60 CCTCTGGAAG CCTTGCGCAO AGCGGACTTT GTAATTGTTO GAGAATAACT GCTGAATTTT 120 TAGCTGTTTT GAGTTGATTC GCACCACTGC ACCACAACTC AATATGAAAA CTATTTNACT 180 TATTTATTAT CTTGTGAAAA GTATACAATG AAAATTTTGT TCATACTGTA TTTATCAAOT CAATGATOAAAA GCAATAGATA TATATTCTTTTTATTATTATGAG GTAATA TATGCCTTTT GTAACTTCAG 360 TTGGTTATTT TATTGTAAAT GAATTACJ ^ AA ATTCTTAATT TAAOAAAATQ GTANGTTATA 420 TTTANTTCAN TAATTTCTTT CCTTGTTTAC GTTAATTTTG AAAAOAATGC AT 472 (2) Sequence identification number 96: ⑴ Sequence characteristics: (A) length: 476 bases (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecular type: cDNA (vi) Source: (A) Biology: Human (xi) Sequence description · Sequence identification number 96 · CTGAAGCATT TCTTCAAACT TNTCTACTTT TGTCATTGAT ACCTGTAGTA AGTTGACAAT 60 GTGGTGAAAT TTCAAAATTA TATGTAACTT CTACTAGTTT TACTTTCTCC CCCAAGTCTT 120 TTTTAACTCA TOATTTTTAC ACACACAATC CAGAACTTAT TATATAGCCT CTAAGTCTTT 180 ATTCTTCACA GTAGATGATG AAAGAGTCCT CCAGTGTCTT GNGCANAATG TTCTAGNTAT 240 AGGTGGATAC ATACNGTGGG AGTTCTATAA ACTCATACCT CAGTGGGACT NAACCAAAAT 300 TGTGTThGTC TCAATTCCTA CCACACTGAG GGACCCTCCC AAATCACTAT ATTCTTATCT 360 GCAGGTACTC CTCCAGAAAA ACNOACAGGG CMGCTTGCA TGAAAAAGTN ACATGTGCGT 42 0 TACAAAGTCf ATCTTCCTCA NANGTGTGTN AAGGAACAAT TTAATCTTCT AGCTTT 476 (2) Information of sequence identification number 97: (i) sequence Column characteristics: -99- This paper size is applicable to China National Standard (CNS) A4 specification (210X297mm) (Please read the precautions on the back first? Page) • Binding and Binding Line 1228593 A7 B7 V. Description of the Invention (97) (A) Length: 479 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (ii) ) Molecular type: cDNA (vi) Source: (A) Biology: human (xi) Sequence description: Sequence identification number 97: ACTCTTTCTA ATGCTGATAT GATCTTGAGT ATAAGAATGC ATATGTCACT AGAATGGATA 60 AAATAATGCT GCAAACTTAA TGTTCTTATAG CATCACTATGCACATCTCACTCACTCAC 〇GATTGTGCTC CTTCQGATAT GATTGTTTCT C / ^ NATGTTGG GCAATNTTCC TTAGTCAAAT 240 CAGGCTACTA GAATTCTQTT ATTGGATATN TGAGAGCATG AAATTTTTAA NAATACACTT 3 00 GTGATTATNA ATGAA GTA ATCAA GTCAA TTCNATCTTA TTTTTTCCCN GACNACTANT TNCTTTlTTA GGGNCTATTC TGANCCATC 479 (2) Information of sequence identification number 98: (i) Sequence characteristics: (A) Length · 461 base pairs (B) Type: Nucleic acid (C) Share type: Single strand (D ) Topology: straight line, printed by the Consumer Cooperatives of the Central Bureau of Standards, Ministry of Economic Affairs (ii) Molecular type: cDNA (vi) Source: (A) Biology · Human (xi) Sequence description: Sequence identification number 98: AGTGACTTGT CCTCCAACAA AACCCCTTGA TCAAGTTTGT GGCACTGACA ATCAGACGTA 60 TGCTAGTTCC TGTCATCTAT TCGCTACTAA ATGCAGACTG GAGGGGACCA AAAAGGGGCA 120 TCAACTCCAG CTGGATTATT TTGGAGCCTG CAAATCTATT CCTACTTGTA CG < 3ACTTTGA ISO AGTGATTCAG TTTCCTCTAC GGATQAGAGA CTGGCTCAAG AATATCCTCA TGCAGCTTTA 240 TGAAGCCACT CTGAACACGC TGGTTATCTA GATGAGAACA GAGAAATAAA GTCAGAAAAT 300 -100 - this paper scale applicable Chinese national standard (CNS) A4 size ( 210X297 mm) A7 B7 1228593 V. Description of Invention (98) TTACCTGGAG AAAAGAGGCT TTGGCTGGQQ ACCA.TCCCAT TGAACCTTCT CTTAAGGACT 360 TTAAGAAAAA CTACGACATG TTGTGTATCC TGGTGCCGGC CGTTTATOAA CTGACCACCC 420 TTTTGGAATA ACGCt CCTOAACTTG CTCCTCTGCG A 461 (2) Information of sequence identification number 99. ⑴ Sequence characteristics: (A) Length: 171 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecular type: cDNA (vi) Source: (A) Biology: human (xi) Sequence description: Sequence identification number 99: GTCGCCGCGC GCAGGTGTTT CCTCGTACCG CAGGGCCCCC TCCCTTCGGC AGGCGTCCCT 60 CGGCGCCTCT GCGGGCCCGA GGAGGACGCGGGGGGGGGTG GGGGGAGTGT GACCCCTCTAGCTCGACCCGCT 120 171 (2) Information for sequence identification number 100: ⑴ Sequence characteristics: (A) Length · 269 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecular type: qDNA (vi) Source: (A) Biology: Human (xi) Sequence description: Sequence identification number 100: -101-This paper is suitable for China National Standards (CNS) A4 (210X297 mm 7 (Please read first) Note on the back page)-Equipment, 1T, printed by the Consumers' Cooperative of the Central Government Bureau of the Ministry of Economic Affairs 1228593 A7 B7 V. Description of the invention (")

CGGCCGCAAG TGCAACTCCA GCTGGGGCCG TGCGGACGAA GATTCTGCCA GGAGTTGGTC CGACTGCGAC OACGGCGGCC3 GCGACAGTCG CAGGTGCAGC GCGGGCGCCT GGGQTCTTGC AAGGCTGAGC TGACOCCGCA GAGGTCOTGT CACGTCCCAC GACCTTGACO CCOTCGGGGA CAGCCGGAAC AGAGCCCX5GT GAAGCGGGAG GCCTCGGGGA GCCGCTCGGG AAGGGCGGCC CGAGAGATAC GCAGGTGCAG GTGGCCGCC (2) Information · Number of SEQ ID 1〇1 ⑴ SEQUENCE CHARACTERISTICS: (A) Length: 405 Base pairs (B) type: nucleic acid (C) strand type: single strand (D) topology: straight line (ii) molecular type: cDNA (vi) source: (A) organism: human (xi) sequence description: sequence ID 101: ΤΤΤΤΤΤΤΓΤΤ TTTTGGAATC TACTGCGAGC ACAGCAGGTC AGCAACAAGT TTATTTTGCA GCTAGCAAGG TAACAGGGTA GGGCATGGTT ACATGTTCAG gtcaacttcc tttgtcgtgg ttgattggtt tgtctttatg ggggcggcqt gggotagggg aaacgaagca aataacatgg AOTGGGTGCA CCCTCCCTGT AGAACCTGGT TACAAAGCTT GGGGCAGTTC ACCTGGTCTG TGACCGTCAT TTTCTTGACA TCAATGTTAT TAGAAGTCAG GATATCTTTT AGAGAGTCCA CTGTTCTGGA GGGAGATTAG GGTTTCTTGC CAAATCCAAC AAAATCCACT GAAAAAGTTG GATGATCAGT ACGAATACCG AGGCATATTC TCATATGGGT GGCCA 60 120 180 240 269 (please read the note on the back page first) • Binding and binding. 60 120 180 240 300 360 405 (2) Information of serial identification number 102: (i ) Sequence characteristics: (A) Length: 470 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology · Straight line (ii) Molecular type: cDNA (vi) Source: -102 -This paper size applies Chinese National Standard (CNS) A4 specification (210X297 mm) 1228593 A7 B7 V. Description of the invention (100) (A) Biological: human (xi) sequence description: sequence identification number 102: TTTTTTTTTT fTTTTTTTTT TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT 'Γ TTTTTTTTTf 60 GGCAGTTAAT CCATTTTTAT TTCAAAATGT CTACAAATTT AATCCCATTA TACGGTATTT 120 TCAAAATCTA AATTATTCAA ATTAGCCAAA TCCTTACCAA ATAATACCCA AAAATCAAAA 180 ATATACTTCT TtCAGCAAAC TTGTTACATA AATTAAAAAA ATATATACGG CTGGTQTTTT 240 caaagtacaa ttatcttaac actgcaaaca ttttaaggaa ctaaaataaa AAAAAACACT 300 CCOGAAAGQT TAAAGGGAAC AACAAATTCT TTTACAACAG CATTATAAAA ATCATATCTC 360 AAATCTTAGG GGAATATATA CTTCACAC QQ OATCTTAAGT TTTACTCACT TTGTTTATTT 420 TTTTAAAGCA TTGTTTCOGC CCAACACAAT GGAATCCCCC CTGGACTAGT 470 (2) Information of sequence identification number 103: (i) Sequence characteristics: (A) Length: 5S1 base pairs (B) Type: Nucleic acid (C) Stock plastic: Single Unit (D) Topology: Straight line (ii) Molecular type: cDNA (vi) Source: (A) Biology: Human (xi) Sequence description: Sequence identification number 103: (Please read the precautions on the back before this page} • installed ·, 11 TTTTTTTTTT TTTmTTGA CCCCCCTCTT αίάαααααοα agttaccatt ttattttact € 0 TACACATATT TATTTTATAA TTGGTATTAG ATATTCAAAA GGCAGCTTTT AAAATCAAAC 12 0 TAAATGGAAA CTGCCTTAGA TACATftATTC TTAGOAATTA GGTTAAAATG TGCCTAAAGT 180 GAA7 \ ATCTTC TCTAGCTCTT TTGACTGTAA AtTTTTGACT CTTGTAAAAC ATCCAAATTC 240 ATTTTTCTTG TCTTTAAAAT TATCTAATCT TTCCATTTTT TCCCTATTCC AAGTCAATTT 300 GGTTCTCTAG CCTCATTTCG TAGCTCTTAT CTACTATTAG TAAGTGGCTT TTTTCCTAAA 360 AGGGAAAACA GGAAGAGAAA TGGCACACAA AACAAACATT TTATATTCAT ATTTCTACCT 42 0 ACOTTAATAA AATAGCATTT TGTGAAGCCA GCTCAAAAGA AGGCTTAGAT CCTTTTATGT 480 CCATTTTAGT CACTAAACGA TATC AAAGTG CCAGAATGCA AAAGGTTTGT GAACATTTAT S40 tcaaaagcta atataagata tttcacatac tcatctttct G 5B1 (2) Information on sequence identification number 104: (i) Sequence characteristics: (A) Length: 578 base pairs -103- + Paper size applies Chinese National Standard (CNS) A4 Specification (210X297 mm)-Printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs 1228593 A7B7 V. Description of the Invention () (B) Type: Nucleic Acid (C) Stock Type: Single Stock (D) Topology: Straight ( ii) Molecular type • cDNA (vi) Source: (A) Biology · Human (xi) sequence description · Sequence identification number 104 · TTTTTTTTTTTTTT n; τTTTTTTTTTTTTTTTTTTTCTCTT ctttttttttgaaatgagga TCGAGTTTTT 60 CACTCTCTAG a ^ agggcatTCTCTACTaaACaaAAaa ATATCATATT TTAAGTTAAA CTAATGAGTG ACTGGCTTAT CTTCTCCTGA ISO ^ GOAAATCTQ ttcattcttc tcattcatat ag ^ tatatca agtagtacct TGCATATTGA 240 GAGGTTTTTO TTCTCTMTT ACACATATTA CTA TCA TACTA CTTCA T TAGTTGGCAG GAGCTAATAC 42 0 AAATCACATT TACGACAGCA ATAATAAAAC TGiAGTACGA GTTAAATATC CAAAATAATT 4B0 aaaggaacat ttttagcctg ggtataatta qctaat ^ cac txtacaagca tttattagaa tg ^ attcaca TGTTATTATT cctaggccaa (i) Sequence characteristics: (A) Length: 538 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecular type: cDNA (vi) Source: ( A) biological: human (xi) sequence Description: SEQ ID NO 105: TTTTTTTTTT TTTTTCAGTA ATAATCAGAA CAATATTTAT TTTTATATTT AAAATTCATA * ¢ 0 gaaaagtgcc ttacatttaa taaaagtttg tttctcaaag tgatcagagg AATTAGATAT 120 GTCTTGAACA CCAATATTAA TTTGAGGAAA ATACACCAAA ATACATTAAG ΤΑΑΑΤΓΑΤΤΤ 180 AAGATCATAG AGCTTGTAA.G TGAAAAGATA AAATTTGAGC TCAGAAACTC TGAGCATTAA 24 0 AAATCCACTA TTAGCAAATA AATTACTATG GACTTCTTGC ΤΤΑΑΓΠΤσ TGATGAAXAT 3 00 GGGGTGTCAC TGGTAAACCA ACACATTCTG AAGGATACAT TACTTAGTGA TAGATTCTTA 360 XGTACTTTGC TAATACGTGG ATATGAGTTG ACAAGTTTGT CTTTCTTCAA TCTTTTAAGO 420 GGCGAGAAAT GAGGAAGAAA AGAAAAGGAT TA.CGCATACT GTTCTTTCTA TGGAAGGATT 48 0 AGATATGTTT CCTTTGCCAA TATTAAAAAA ATAATAATGT TTACTACTAO TGAAACCC 538 -104- This paper standard applies to China National Standard (CNS) A4 Standard (210X297). Printed 1228593 A7 B7 V. Description of the invention (1Q2) (2) Sequence identification number 10 6 · (i) Sequence characteristics: (A) Length: 473 base pairs (B) Type: Nucleic acid (C) Stock type: Single strand (D) Topology: Straight line (ii) Molecular type: cDNA (\ ά) Source: (Α) Biology: Human (xi) Sequence description: Sequence identification 106: TTTTTTTTTTTTTTTTTTTTTAGTC AAGTTTCTAT TTTTATTATA ATTAAAGTCT TGGTGATTTC 60 ATTTATTAGC TCXGCAACTT AAAAATTAMA CGTTTTAGAC AACTGTACAA 120 TTTATAAATG TAAGGTGCCA TTATTGAGTA ATATATTCCT CCAAGAGTGG ATGTGTCCCT '180 TCTCCCACCA ACTAATGAAC AGCAACATTA GTTTAATTTT ATTAGTAGAT ATACACTGCT 240TAGAAACAGCCATCCATCATTCTCTTCT CCATCCCCAT GTGATATAGAGGCGTCAGTCA T 3 $ 0 AGACTGTGTC TGTCTGAATC AAATGATCTG ACCTATCCTC GGTGGCAA ($ A ACTCTTCGAA 420 CCGCTTCCTC AAAC5GCGCTG CCACATTTGT GGCTCTTTGC ACTTGTTTCA AAA, 47 3 (2) Information on sequence identification number 107: (i) sequence length 1J base: 16A (B) Type: Nucleic acid. Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs (C) Stock type: Single stock (D) Topology: Straight line (ii) Molecular type: ct) NA (vi) Source: (A) Biology : Human (xi) sequence description: Sequence identification number 107: -105- This paper size applies to Chinese National Standard (CNS) A4 specification (210X297 mm) 1228593 A7 B7

Description of the invention (1Q3) CGCCATGGCA CTGCAGC3GCA TCTCGGtCAT OGAGCTGTCC OGCCTC3GCCC CGGGCCCGTT 60

CTGTGCTATG GTCCTGGCTG ACTTCGGQGC GCGTGTCGTA CQCGTGGACC QGCCGGGCTC 12 Q

CCGCTACGAC GTGAGCCGCT TGGGCCGGGG 'CAAGCGCTCG CTAGTGCTGG ACCTGAAGCA XBO GCCGCGGGGA GCCGCCGTGC TGCGGCGTCT GTGCAAGCGG TCGGATGTGC TGCTGGAGCC 240 CTTCCGCCGC GGTGTCA-TGG AGAAACTGCA GGTGGGCGCA GAGATTCTGC AGCGGGAAAA 3 0 0 TCCAAGGGTT ATTTATGCGA GGCTGAGTGG ATTTGGCCAG TCAGGAAGCT fCTGCCGGTT 360 AC3CTGGCCAC GATATCAFVGT ivTTTGGCTTT GTCAGGTGTT CTCTCAAAAA TTGGCAGAAG 420 TGGTGAGAAT CCGTATGCCC CGCTGAATCT CCTGGCTGAC TTTGCTGGTG GTGGCCTTAT 4Θ0 QTGTCCAGTG GGCATTATAA TGGCTCTTTT TGACCGCACA CGCACTGACA AGGOTCAGGT 540 CATTGATGCA AATATGGTGG AAGGPACAGC ATATTCTAAGT TCTTTTCTGT GGAAAACTCA 6〇〇GAAATCGAGT CTGTGCGAAG CACCTCGAGG ACAGAACATG TTGGATGGTG GAGCACCTTT 660 CTiLTACGACT tacaggacag cagatgggga attcatggct GTTGGAGCAA TAGAACCCCA 720 GTTCTACQAG GTGCTGATGA AAGOACTTGG ACTAAAGTCT GATGAACTTC CCAATCAGAT 780 GAGCATGGAT GATTGGCCAG AAATGAA-QAA GAAGTTTGCA QATGTATTTG CAAAGAAGAC 840 gaaggcagag tggtgtcaaa tctttgacgg cacagatgcc tgtgtgactc CGGTTCTGAC 900 TTTTGAGGAG GTTGTTCATC ATGATCACAA CAAGOAACGG GGCTCGTTTA TCACCAGTGA 960 GGAGC AGGAC GTGAGCCCCC GCCCTGCACC TCTGCTGTTA AACACCCCAG CCATCCCTTC 1020

TTTCAAAAGG GATCCTTTCA TAGGAGAACA CACTGAGGAG ATACTTGTVAG AATTTGGATT lOfiO CAGCCGCGAA GAGATTTATC AGCTTAACTC AGATAAAA.TC ATTGAAAGTA ATAAGGTAAA 1140 AGCTAGTCtC TAACTTCCAG GCCCACGGCT CAAGTGAATT TGAATACTGC ATTTACAGTG 1200 tagagtaaca cataacattg tatgcatgga aacatggagg AACAGTATTA CAGTGTCCTA 12 $ 0 CCACTCTAAT caagaaaaga. Attacagagt ctgattctac agtgatgatt GAATTCTAAA station 3 20 AATGGTt / lTC attagggctt ttgmttata aaactttggg TACTTATACT AAATTATGGT 13 Θ0 AGTTATTCTG CCTTCCAGTT TGCTTGATAT ATTTGTTGAT ATTAAGATTC TTGACTTATA 1440 TTTTGAATGC GTTCTAGTGA AAAAGGAATO ATATATTCTT OAAGACATCG ATATACATTT: 1500 ATTTACACTC TTGATTCTAC AATGTAGAAA ATGAGOAAAT GCCACAAATT GTATGGTGAT 1S60 AAAAGTCACG TGAKACAAAA ΑΑΑΑΑΑΑΑΑΑ AAAAAAAAAA KAAAAAAA ^ (2) SEQ ID A AAAAJ \ AAAAA 1620 A 1621 number of l〇8 information: (i ) Sequence characteristics: (A) Length: 382 amino acids (B) type · amino acids (C) strand type: single strand (D) topology · straight line (ii) molecular type: protein (vi) source : (A) Biology: Human (xi) Sequence description: Sequence identification number 108: '

Met Al < i Leu Gin Gly lie Ser Val Met Glu Leu Ser Gly Leu AXa Pro 15 10 15

Gly Pro Phe Cyc Ala Met Val Leu Ala Asp Phe Gly Ala Arg Val Val 20 25 30

Arg Val Asp Arg Pro Gly Ser Arg Tyr Aap Val Ser Arg Leu Gly Arg 35 40 45

Gly hye Axg Ser Leu Val Leu Asp Leu Lys Gin Pro Arg Gly Ala Ala SO 56 eo val Leu Arg Arg Leu Cys Lye Arg Ser Asp Val Leu Leu Glu Pro Phe 65 70 7S 80 -106- This paper size applies to Chinese national standards ( CNS) A4 specification (210X297 mm) 1228593 A7 B7 V. Description of the invention (104)

Arg Arg Gly Val Met Glu Lys Leu Gin Leu Gly Pro Glu ϊΐβ Leu Gin 85 90 95 Arg Glu Asn Pro Arg Leu lie Tyr Ala Arg Leu Ser Gly Phe Gly Olti 100 10S no ser Gly Ser Phe Cys Arg Leu Ala Gly His Asp He Asn Tyr Leu Ala 115 120 125 Leu Ser Gly Val Leu Ser Lys lie Gly Arg Ser Gly Glu Asn Pro Tyr130 130 135 140 Ala Pro Leu Asn I ^ eu I * eu Ala Asp Phe Ala Gly G] Ly Gly Leu Met Cys 14 5 ISO 155 ISO Ala Leu Gly He lie Met Ala Leu Phe A $ p Arg Thr Arg Thr Asp Iiys 165 170 175 Gly Gin Val He Asp Ala Asn Met Val Glu Gly Thr Ala Tyr Leu Ser 180 185 150 Ser Phe Leu Trp Lys Thr Glu Lys Ser Ser Leu Trp Glu Ala Pro Arg 155 200 205 Gly Gin Asn Met Leu A.sp Gly Oly Ala Pro Phe Tyr Thr Thr Tyr Arg 210 215 220 Thr Ala Asp Gly Glu Phe Met Ala Val Gly Ala lie Glu Pro 〇! Ln Phe 22S 230 235 240 Tyr Glu Leu Leu lie Lys Gly Leu Gly Leu Lys? Ser Asp Glu Leu Pro 245 250 255 Asn Gin Met Ser Met Asp Asp Trp Pro Glu Met Lys Lys Lys Phe Ala 2 € Q 265 270 Asp Val Phe Ala Lys Lys Thr Lys Ala Glu Trp Cys Gin lie Phe Asp 275 280 285 Gly Thr Asp Ala Cys Val Thr Pro Val Leu Thr Phe Glu Glu Val Val 290 295 300 His His Asp His Asn Lys Glu Arg Gly Ser Phe He Thr Ser Glu Glu 305 310 315 320 Gin Asp Val Ser Pro Arg Pro Ala Pro Leu Leu Leu Asn Thr Pro Ala 32S 330 335 lie Pro Ser Phe Lys Arg Asp Pro Phe Gly Glu His Thr Glu Glu 340 345 350 lie Leu Glu Glu Phe Gly Phe Ser Arg Glu Glu lie Tyr Gin Leu Asn 355 360 365 Ser Asp Lys lie Glu Ser Asn Lys Val Lys Ala Ser Leu 370 375 3Θ0 (Please read the precautions on the back before this page) • Installation ·

Line 1T Printed by the Consumer Cooperatives of the Central Bureau of Standards of the Ministry of Economic Affairs

(2) Information of sequence identification number 109: (i) Sequence characteristics ... (A) Length ... 1524 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line ( ii) Molecular type: cDNA -107-This paper size is in accordance with Chinese National Standard (CNS) A4 specification (210X297 mm) 1228593 A7 B7 105 V. Description of the invention ((vi) Source (xi) Sequence description: Sequence identification number 109

GGCACGAGGC TGCGCCAGGG GGGCCTGGCC ATGCCTCACT CAGTGCGACC TAGTGGCTCT ggtttgtacc acgtgogccg ctgcttcaca tcttcacggt atgatgaago acgtgttctt GTOGGCACGG AGGGGCTCCT GTCTXCTACC GTCCCTACCCCA GCCCTCAT

ATCTTCCTGC ACA (ATC CGCCTCCTGC CTCGAGCATT TCCG

^ TTCGGCA □ CGGGAAT

TCGOTGCATA AGOAGAAGTT GAGCGTCTGA AGCGCACGTC CGCGAGTACG AACAGCGCCT CTGGGGTGGG TGGCCQAGGC CCCCCTGACC TGCCTGGGTC GCACAGGGGA TTTTGCtCCT GCCTTGTCCT TGAGGTGAGC gtgtcatcct tacaaaccac GGATCAAGCCCAGCGCACCGACC

TCGTGGCCAA AAGTACAGGG TCCACTCTCG TCAGGGAATT: GGGTTTA

CCTGAGCGGA

GAGCCAGCGC

CACCTGCTTC

CACTGTCCTC

CAACAAACAG cttcctcttc

GkQGCCACGO

GCAOATCTTC

CTGCTCGTCG

CTCCCAGTAT

CATCCTGCTG

CAACAGCGAT

GCCCGCGCTG gtgcagocga

cemcTAAG

TCTGCTGGCA

CCAGAAOGTG

GAJVAGTGCTG

CCTGAGCCGC

CAAAGACTGA

AGAGTAAGOC

CCCATGTCCA

AGCATGCCCG

GGCCGTTATC

CCACTCACAG

GGCGGGGGCA

CTGCGCCTCT

CTCCTGGdCG

TGCATCGACT

CTGGGGCCCA

TTCCTCGGCG

GACAGTGACT

GGGCAGATTC

GAGCCCGGCT

OCCAACTGOC

• GTCAACTTGC

CTCTACTGGA

GCCCCGCCCT

CGCCGGAGCG

GAAGCCGAGC

CGCGCTAGGG

GACTTGGCAC

GAGCGGGAGG

TCTGCCTXGG

GGCCTGCTGG

TCATCTGGGC

TCTGGGCCAC

GCTGCTCGCA

CATCTGGAGG ATTCCTCACA gcctcgccag

ACCTCGCCGA

TGGGCTGCCG

TCATGGTTTT

AGATCGTCAT

TGTGQCTGGT

TCCCAAGTAT

CCCAGGAGGA

TCTGOOCACA

TGGTGGTGCT

TCATTGCCAT

AGGCGCAGCG

TTATCGTCAT

CCCAGCCGTC

GGAAGCTGCT

ACAAGCGGGA

TGAAACAGCT

TCCAGCAGTG

TGCCCCCAGG

CGGACTTCAA

CTCGGCCCCC

TGTCAGGACG

OAACCAGTCC

CTGCAGGGTC

CTGGGGAAAT

CGGGGGCCCC

CAGCTGGAAC

GCTGACCCCG

CACGGTGCGG

CC3TGAGCAAO

AGCCTATOGC

CCTGCGCCGC

CATGGACGTG

CCCTCCTGGO

GCTCCTCGTC

GTTCAGTTAC

TTACCGCCTC

CTCCCACTTG

CTCCCCGGCC

AACGTGGGAA

GAGCGACTCC

GGGACACATC

TAGCCGCGTC

TGGGCCGCCA

GGAGAAGCCC

GCACCTOOTG

ACCTTTGGGA

CAGCCTGGGA

CTTGGGGTAA aaagccattt 60 120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1524 (2) Information of sequence identification number 110: (i) Sequence characteristics: (A) Length: 3410 Base pairs (B) Type: Nucleic acid • Printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs (C) Stock type: Single strand (D) Topology: Straight line (ii) Molecular type: eDNA (\ 4) Source: ( A) Biology: Human (xi) sequence description: Sequence identification number 110-108- This paper size applies Chinese National Standard (CNS) A4 specification (210X297 public attack) 1228593 A7 B7 V. Description of the invention (106), the central standard of the Ministry of Economic Affairs Board member H; Printed by Consumer Cooperative

GGOAACCAGG GTGATGAGAC AAGGTGGACG GGCGGCAGCA GAGTGCCTGA GGTGAGCCGC TGGCCTGGAG GGGGGTAGAG CTGTGTCCCG GCCCTTCATG CCGCTGGCTA CGTGGGCGTG GCTCTCTCAC CATGATCAOT TGCCCXGGCC CTTCCTCACC CGAGCCAGCA CCGCTTGGCT CATGCCCCGC GACCTTCACO AOCTGAGCCG qgggctgttc GCAGCGATTC CGC3TGCCACA QTTCACCTTC gaagcaggtg CCTGATQACC GGGTGCTGGA TGATGTCTCG GGGCATCTGC ATCCCTGTTT TGCCGCAGGC CGACTTGGC. GACTGGGTCC TTCTGTtGCT GCTGCACAGC ACTGOAGGCC ATGCACTGGA CTCCTAGTTO GTTTCCCATC tttctacgat GtCCTGAGGG QATCCACCCG CAGAGACACA tgctagcttt GGTCCCCTGA CTGGCCGGTCCC GCCTCACGTCTCACC

CTGCAGGCGC GTGTCCCCAC GGCACCAAAG AGGAGGA.GAG ACGGCCCGCt CTGCTGCGGC GTGTGTTTGG GAQAAGTTCA CTCCTAGGCT TGGGCACTGT GCAGGGCTGC GGGCTGCTGG CTCTTCCGGG CTXGGGGGCT GCCTACCTGO TGCGTAGCAG GAAGGGCTGT TTCCGGAAGC AGCCTGCGCG CTGTTTTACA ggcaccgagg GTGCAGTGCG GOCACTCGAG TGCCTGTCCC TCAGCCCTGC TTCCTGCCCA AGCTTCCTGC GGCAGTGGCC gtacgtgtgg GTGGA.CCTCG ATGGGCTCCA CTGGGTCTGG AAATACTCAG CAGCTCCCCG GCCAAAGTAA TGGGGGCTGG TTCCAAGOGG ATGCGGGGAC AGACACACCT TCTAAGCCCC GAAACACTCC GCAACACACA CCTCTTACGT GGCATTTAAA TCTGTGTTGG GATAGCTGGT AAAATGCCTA GTTACCCAAG TCCCTAACCA CTCTCTCTAQ CCCTACCCCC AAGCACAAAG TTGGGOAATC CTCTGAGGGG AATATTTTAT CTTTCTTATA

TGGCTCCGGG TGAGGTGCCC GGCTGGCAGA gccgcagctt GAGCCCTACC ACCGGAAAGC CCGCAGGCAT TGACCATGGT CAGCCAGTGA CCTTGGGCAT TGTGCCCGGA AGTTCTGTGG ACCCGGACCA GCCTGGGCTA GCACCCAGCA CCACACTGCT CGGCCCCCTC TGGGCGCCCT GGCTCTTCGT CGGATTTCGT CCCGGAGACA CCATCTCCCT CAGTCTATTT ACAGTGTGGC agatcctgcc AATACCGAGO CAGGCCCTAA TOCTCCCACG TGGTGGGTGA CCATCCTGGA TTGTCCAGCT TCGCCATTTA CGTAGAAAAC CTCCTGTTAG TGTGGCTCTC GGCGTCCCTC GTTTCAGTCT TCTGCAGGTG AGAGAAGGGT TTAACCTGCA TCCATGGCAT AGAACCAGGT TTTATCAGGA TATTTAACTT TGTCTAATAT CATTGGGCTG ACCCAGGACC GTTAGGGTGT CCCGTCTTCT GACTGGGCTG AACTTTCCCC TGCGGTTTCC TOiVCACAGAA GGGTTTAAGT ACTGTAAGTG TGTTTAAAAA

TGACAGCCGC GCGCCTCGGC CAGGATCTGA CACAGCAGCA GGTGTTGAGC ATGGGCTGAG AATGGGCGCC TGGCTGATTC CTAGGGAGTT CTGGAGCAGA GCCGAGACGA AGCAGTTCTG CGCCTGGCCC ACTATGGTCG agaoggtgtg GCAGCTCTTG GTC ^ GTCAACC TGCTAACCTT CACCTATGTG CCGCCTGTGC TGCTGGAAGT GCTGGGCATT GGTCCAGTGC TGGGCCTGGT CCACTGGCGT GGACGCTATG GCCGCCGCCG CCTGCTGAGC CTCTTTCTCA TCCCAAGGGC TCCGAGGCCC CTGGAGCTGG CACTGCTCAT CCAGGTGTGC TTCACTCCAC TGGAGGCCCT CTGTCGCCAG GCCTACTCTG TCTATGCCTT CCXCGTGCCT GCCATTGACT GGGACACCAG GGAGTGCCTC TTTGGCCTGO TCACCCTCAT GGTGGGTGAG GAGGCAGCGC TGGGCCCCAC CTTGTCGCCC CACTGCTGTC CATGCCGGGC GCTTCCCCGG CTGCACCAGC TGTGCTGCCG GGCTGAGCTG TGCAGCTCJGA TGGCACTCAT GGGCGAGGGG CTGTACCAGG GCGTGCCCAG ctatgaxgaa ggcgttcgga tgggcagcgt GOTCTTCTCT CTGGTCATGG ACCOGCTGGT GGCCAGTGTQ GGAGOTTTCC CTGTGGCTGC CGTGGTOACA GCTTCAGCCG CCCTCACCGG CTACACACTG GCCTCCGTCT ACCACCGGGA ggacactgga ggtggtagca gtgaggacag gcctggagct cccttcgcta atggacacgt TCCACCCGCO CTCTGCGGGG CCTTCTGCCTa GCCCACCGAG GCCAGGGTGG TTCCGGGCCG TAGTGCCTrC CTGCTGTCCC AGGTGGCCCC CAGCCA. GTCT GTCACTGCCT ATATGGTOTC CTTTGCTACA CAGGTAGTAT TTQACAAGAG TTCCAGCAC ^ TTGGGGTGGA GGGCCTGCGT CCCCATGGGG CTGCCGGGCT GGCCGCCAGT TGCTGCCACC CTGTGCTGCT OAGGTGCGTA TCCTCTCTCC CCAGTCTCTA QQGCTGCCTG ggacttatag aggoagqcca gaagggctcc gattacccag gctcagggtt aacagctagc TTTTGGGAGG TGAATAAACT CAGTCACCTG gcttcgttta atgtagctgt tgcatgggag TTGAACATAT GACTTATTTQ TAGGGGAAGA cccgtcagcc cacagcactg tctttttgct TGTGGCGTGT TGGTCCTTCT GTTGCCATCA atttatttaa caaagtagaa oggaatccat TTOGGTAGGO TGGGGGATCC CCAACAATCA ATCATTGCCA GAATCTTCTT CTCCTGGGGT TTGGAAATTC TACTCATCCC AAATGATAAT TGAAGGAAGG TAGAGGGTGG GGCTTCAGGT CTTGGCCCAG CCTGGTTCCC CCCACTTCCA ATGAAGGCAG TGCCCAAAAT TTCCCCTACC accagctcca caacoctgtt tgoagctact CAAGCCTTTG TCCATCTCAG CCCCCAGAGT ACTCAGGAGC ACCCCCTGCC TGAGCTAAGG GCCGTTTCCA ATAATGTCGT CTTATTTATT AGCAATCAGA GTAXAATGTT TA.TGGTGACA eo 120 180 240 300 360 420 480 S4Q ^ 00 660 720 780 840 900 9 (50 1020 1080 114 0 1200 12 ^ 0 1320 1380 1440 1S00 1560 1β20 1680 1740 1800 1920 19β〇2040 2100 2160 2220 2280 2340 2 400 2460 2520 2580 2640 2700 2750 2820 2880 2940 3000 3060 3120 3190 3240 3300 3360 3410 (Read the precautions on the back 舄 This page-binding-Thread _ 109-This paper size applies to China National Standard (CNS) A4 specifications ( 210X297 mm) 1228593 A7 B7 V. Description of the invention (1Q7). Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs (2) Information on sequence identification number 1 Π: ⑴ Sequence characteristics: (A) Length: 1289 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecular modeling · cDNA (vi) Source: (A) Biology: Human (xi) Sequence description: Sequence recognition 1 U No: AGCCAGGCGT CCCTCTGCCT GCCCAGTCAG TGGCAACACC CGGGAGCTGT TTTGTCCTTT 60 GTGGAGCCXC AGCAGTTCCC TCTTTCAGAA CTCACTGCCA iuGAGCCCTGA ACAGOAGCCA 120 CCATGCAGTG CTTCAGCTTC ATTAAQACCA TGATGATCCT CTTCAATTTG CTCATCTITC 180 TGTGtGGTGC AGCCCTGTTG GCAGTGGGGA TCTGGGTQTC AATCGATGGG GCATCGTTTC 240 TGA7VGATCTT CGGGCCACTG TCGTCCAGTG CCATGCAQTT TGTCAACGTG GGCTACTTCC 3〇〇TCATCGCAGC CGC3CGTTQTO GTCTTTGCTC TTGGTTTCGT GGGCTGCTAT GGTGJCTAAGA 360 ctoagao caa g ^ gtgccctc gtgacgttct tcttcatcct CCTCCTCATC TTCATTGCTG 420 AGQTTGCAGC TQCTGTGGTC GCCTTGGTGT ACACCACAAT G < 3CTGAGCAC TTCCTGACQT 480 TQCTGGTAGT QCCTC3CCATC AAGAAAQATT ATGGTTCCCA GGAAOACTTC ACTCAAQTGT 540 GGAAGACCAC CATOAAAQGQ CTCAAGTGCT GTGGCTTCAC CAACTATACG GATTTTGAGG βΟΟ ACTCACCCTA CTTCAAAGAG AACAGTGCCT TTCCCCCATT CTGTTGCiAAT GACAACGTCA S60 CCAACACAGC CAATGAAACC TGCACCAAGC AAAAGOCTCA CGACCAAAAA GTAGAOGGTT 720 GCTTCAATCA GCTTTTGTAT GACATCCGAA CT ^ TGCAGT CACCGTGGGT GGTOTGOCAa 7Θ0 CTGGAATTGO GGGCCTCGAG CTGGCTGCCA TGATTGTGTC CATGTATCTG TACTGCAATC 840 TACAATAAGT C3CACTTCTGC! CTCTGCCACT ACTGCTGCCA CATGGGAACT GTGAAGAGG. 900 ACCCTGGCAA GCAGCAGtGA TTGGGGGAGG GGACAQGATC TAACAATGTC ACTTGGGCCA 96Q QAATGGACCT gccctttctg ctccagactt gqggctagat AGGOACCACT CCTTTTAGCG 1020 ATGCCTGACT TTCCTTCCAT TGGTGGOTGO ATGGGTGGGG GGCATTCCAG AGCCTCTAAO 1080 GTAGCCAGTT CTGTTGCCCA TTCCCCCAGT CTATTAAACC CTTGATATGC CCCCTAGGCC 1140 TAQTGGT (3AT CCCAGTGCTC TACTGGGGGA TGAGAGAAAG GCATTTTATA GCCTGGGCAT 1200 AAGTC3AAATC AQCAGAGCCT CTGC3GTGOAT GTGTAGAAGG CACTTCAAAA TXSGATAAACC 1260 TGTTACAATG ΤΤΜΑΑΑΑΑΛ AAAAAAAAA 1289 ( 2) Information on sequence identification number 112: (i) Sequence characteristics: (A) Length: 315 amino acids (B) Type: Amino acid (C) Stock type: Single strand -110- This paper size applies to China Standard (CNS) A4 size (210X297 mm) (Please read the precautions on the back page first)-Installation · Line 1228593 A7 B7 V. Description of the invention (108) (D) Topology: straight line (ii) Molecular type: protein (vi) Source: (A) Biology: Human (xi) Sequence description: Sequence identification No. 112, printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs

Met Val Phe Thr Val Arg lieu Leu His lie Phe Thr Val Asn Lys Gin 15 l〇is X, eu Gly Pro Lys lie Val lie Val Ser Lys Met Met Lys Asp Val Phe 20 25 30 phe Phe Ixe \ i Phe Pha I « eu Gly Val Tip Leu Ala Tyr Gly Val Ala 35 40 4S Thr Glu Gly Leu IjGU Arg Pro Arg: Asp Ser Asp Phe Pro Ser lie Leu 50 55 60 Arg Arg Val Phe Tyr Arg Pro Tyr Leu Gin lie Phe Gly Gin Ilo Pro g5 70 7S 80 Gin Glu Aap Met Asp Val Ala Leu Met Glu His Ser Asn Cys Ser Ser 85 90 95 Qlu Pro Oly Phe Trp Ala His Pro Pro Gly Ala Gin AXa Gly Thr Cys 100 105 110 Val Ser Gin Tyr Ala Asn Trp Leu Val Val Leu lieu Leu Val He Phe 115 120 125 Leu Leu Val Ala Asn lie Leu Leu Val Asn Leu Leu lie Ala Met Phe 130 135 140 — Ser Tyr Thr Phe Oly Lys Val Qln Gly Asn Ser Asp Leu Tyr Trp Lye 145 150 155 160 Alii Gin Arg Tyr Arg Leu He Arg Glu Phe His Ser Arg Pro Ala Leu 165 170 17S Ala Pro Pro Phe lie Val lie Ser His Leu Arg Leu Leu Leu Arg Oln 180 185 190 Leu Cys Arg Arg Pro Arg Ser Pro Oln Pro Ser ser Pro Ala Leu Glu 155 200 205 His Phe Arg Val Tyr Leu Ser Lya Glu Ala Glu Arg Lys Leu Leu Thr 210 215 220 Trp Glu Ser Val His Lys Glu Asn the i ^ eu Leu Ala Arg Ala Arg Asp 225 230 235 240 Lys Arg Glu Ser Asp Ser Glu Arg Leu Lya Arg Thr ser Gin Lys V ^ l 245 250 255 Asp Leu Ala Leu Lys Oln Leu Oly His lie Arg Glu Tyr Glu Gin Arg 260 265 270 Leu Lya Val Leu Glu Arg Glu Val Gin Gin Cys Ser Arg Val Leu Gly 275 280 285 Trp Val Ma Glu Ala Leu Ser Arg ser Ala Leu Leu Pro Pro Gly Glv 290 295 300 Pro Pro £ > r〇Pro Asp Leu Pro Gly Ser Lys Asp 3〇5 310 315 -111-

(Please read the Precautions on the back page first}-Binding · Binding-Thread · 1228593 A7 B7 V. Description of the invention (1 (59) (2) Information of Serial Identification No. 113: ⑴ Sequence Features: (A) Length: 553 Amino acid (B) type: cavity acid (C) strand type: single strand (D) topology: straight line (ii) molecular type: protein (vi) source: (A) organism: human (xi) sequence description : Sequence identification number 113:

Met Val Gin Arg Trp Val Ser Arg Leu Leu Arg His Arg Lys Ala X 5 10 15

Gin Leu Leu Leu Val Asn Leu Leu Thr Phe Gly Leu Glu Val Cya Leu 20 25 3〇

Ala Ala Gly Le Thr Tyr Val ϊ > ι Pro Prouu Leu Leu Glu Val Gly Val 35 40 45

Glu Glu Lya Phe Met Thr Met Val Leu Gly lie Gly Pro Val Leu Gly 5〇 55 € 0

Leu Val Cys Val Pro Leu Leu Gly Ser Ala Ser Asp His Trp Arg Gly

55 70 7S BO

Arg Tyr Gly Arg Arg Arg Pro Phe lie Trp Ala Leu Ser Leu Gly lie 85 9〇 95

Leu Leu Ser Leu phe Leu lie Pro Arg Ala Gly Trp Leu Ala Gly Leu 100 10S xio

Leu Cys Pro Asp Pxo Arg Pro Leu Glu Leu Ala Leu Leu lie Leu Gly 115 120 125

Val Gly Leu Leu Asp Phe Cyg Gly Gin Val Cys Phe Thr Pro Leu Glu 130 135 140

Ala Leu Leu Ser Asp Leu Phe Axg Aap Pro Asp His Cys Arg Gin Ala 145 ISO 155 l $ 〇

Tyr Sex: Val Tyr Ala Phe Met: lie Ser ΙιβίΑ Gly Gly Cys Leu Gly Tyx 165 170 175

Leu Leu Pro Ala lie Asp Trp Asp Thr Ser JUa Leu Ala Pro Tyr Leu 180 1Θ5 190

Gly Thr Gin OXu Glu Cys Leu Phe Gly Leu Leu Thr Leu lie Phe Leu 195 200 205 -112- This paper size applies to China National Standard (CMS) A4 specification (210X297 mm) (Please read the precautions on the back before uploading this paper Page • Loading ·

1T, printed by the Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs 1228593 A7 B7

V. Description of the invention (11G • Printed by the Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs

Thr Cys Val Ala Ala Thr Leu Leu Val Ala Glu Glu Ala Ala Leu Gly 210 215 220 Pro Thr Glu Pro Ala Glu Gly Leu Ser Ala Pro Ser Leu Ser Pro His 225 230 235 240 Cys Cys Pro Cys Arg Ala Arg Leu Ala Phe Arg Asn Leu Gly Ala Leu 245 250 255 Leu Pro Arg Leu His Gin Leu Cys Cys Arg Met Pro Arg Thr Leu Arg 260 265 270 Arg Leu Phe Val Ala Glu Leu Cys Ser Trp Met Α1 »Leu Met Thr Phe 275 280 285 Thr Leu Phe Tyr Thr Asp Phe Val Gly Glu Gly Leu Tyr Gin Gly Val 290 295 300 Pro Arg Ala Glu Pro Gly Thr Glu Ala Arg Arg His Tyr Asp Glu Gly 305 310 315 320 Val Arg Met Gly Ser Leu Gly Leu PhG Leu Gin Cys Ala lie Ser Leu 325 330 335 Val Phe Ser Leu Val Met Asp Arg Leu Val Qln. Arg Phe Gly Thr Arg 340 345 350 Ala Val Tyr Leu PJ. 3X Ser Val Ala Ala Phe Pro Val Ala Ala Gly Ala 355 360 365 Thr cys Leu Ser His Sex val Ala Val Val Thr Ala Ser Ala Ala Leu 370 375 380 Thr Gly Phe Thr Phe Ser Ala Leu Gin He .Leu Pro Tyr Thr Leu Ala 385 330 395 400 Ser Leu Tyr His Arg Glu Lys Gin Val Phe Leu Pro Lys Tyr Arg Gly 405 410 415 Asp Thr Gly Gly Ala Ser ser Glu Asp Ser Leu Met Thr Ser Phe Leu 420 425 430 Pro Gly Pro Lys Pro Gly Ala Pro Phe Pro Asn Gly Hi3 Val Gly A1 & 435 440 445 Gly Gly Ser Gly Leu Leu Pro Pro Pro Pro Ala Leu Cys Gly Ala Ser 450 4SS 460 Ala Cys Asp Val Ser Val Arg Val Val V ^ l Gly Olu Pro Thr Glu Ala 465 470 475 480 Arg Val Val Pro Gly Atg Gly He Cye Leu Asp hcu Ala lie Leu Asp 465 490 495 Ser Ala Phe Leu Leu ser Gin Val Ala Pro Ser Leu Phe Met Gly Ser 500 S05 510 113 This paper size applies to China National Standard (CNS) A4 (21GX297 mm)--------- I -I- · Γ · -1- —LI--II -I- == I (Please read the note on the back page first) Order 1228593 A7 B7 V. Description of the invention (111), printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs lie Val Gin Leu Ser Gin Ser Val Thr Ala Tyr Met vslI Ser Ala Ala 515 520 525 Gly Leu Gly Leu Val Ala lie Tyr Phe Ala Thr Gin Val val Phe Asp 530 535 540 Lye Ser Asp Leu Ala Lys Tyr Ser Ala 545 550 ( 2) Information of sequence identification number 114: (i) sequence characteristics: (A) long : 241 amino acids (B) Type: Amino acid (C) Strand type: Single-strand 乂 1>) Topology: Straight line (ii) Molecular type: Protein (vi) Source: (A) Biology · Human ( xi) Sequence description: Sequence identification number 114: Met Gin Cys Phe Ser Phe lie Lys Thr Met Met lie Leu Phe Aan Leu X 5 l〇15 Leu He Phe Leu Cys Gly Ala Ala Leu Leu Ala val Oly lie Trp Val 20 25 30 Ser lie Asp Gly Ala Ser Phe Leu Lya lie Phe Gly Pro Leu Ser Ser 35 40 45 Ser Ala Met Gin Phe Val Asn Val Gly Tyr Phe Leu lie Ala Ala Oly SO S5. ¢ 0 Val Val Val Phe Ala Leu Gly Phe Leu Gly Cys Tyr Gly Ala Lys Thr 65 70 75 B0 Glu Ser Lys Cys Ala Leu Val Thr Phe Phe Phe lie Leu Leu Leu lie 85 90 95 Phe He Ala Glu Val Ala Ala Ala Val Val Ala Leu Val Tyr Thr Thr 100 105 110 Met Ala Glu His Phe Leu Thr Leu Leu VaX Val Pro Ala lie Lys Lya 115 120 125 Asp Tyr Gly Ser Gin Glu Asp Phe Thr Gin Val Trp Αβϊι Thr Thr Met 130 135 140 (Please read the precautions on the back before this one hundred. ·

、 1T ___- 114- This paper size applies to Chinese National Standard (CNS) A4 specification (210X297 mm) 1228593 A7 B7 V. Description of invention (112

Lys Gly Leu Lys Cys Cys Gly Phe Thr Asn Tyr Thr Asp Phe Gin Asp 14 S 150 155 160 Ser Pro Tyr Phe Lys Glu A Day Ser Ala Phe Pio Pro Phe Cys Cys Asn 165 170 175 Asp Asti Val Thr Asn Thr Ala Asn Glu Thr Cys Thr i ^ ys Gin Lys A.la 180 185 190 Asp Gin Lys V ^ l Glu Gly Cys Ph 巳 Asii Gin Leu lieu Tyx Asp lie 195 200 205 Arg Thr Asn Ala Val Thr Val Gly Gly Val Ala Ala Gly lie Gly Gly 210 215 220 Leu Glu Leu Ala Ala Met lie Val ser Met Tyr Leu Tyr Cys Asn Leu 225 Gin 230 235 240. Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs (2) Information on serial identification number 115: (i) Sequence features: (A) Length: 366 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecular type ·· cDNA (vi) Source: (A) Creature: Human (xi) Sequence description: Sequence recognition number 115 · AACGAT · TTAAAA!

GCTCTTTCTC TCCCCTCCTC TGAATTTAAT TCTTTCAACT TGCAATTTGC TGATGTATAT TOTQTTGOAA AAAAAAAAAA OTGTCTTTGT TTGGTTTGTO AATCCATCTT GCTTTTTCCC CATTGGAACT AGTCATTAAC CCATCTCTGA CATTT 丨 ’CACTG: TTGT.

kTTAC

ACTGGTAGAA AAACA.TCTGA AGAGCTAGTC TATCAGCATC! TGACAGGTGA ATTGGATGGT TCTCAQAACC ATTTCACCCA GACAGCCTGT TTCTATCCTG TTTAATAAAT TAGTTTGGGT TCTCTACATG CA.TAOC4AQC (China National Standards of China) 360 TCGCTCATC ATC ATGGTCT 1228593 A7 B7 V. Description of the invention (113) (2) Information on sequence identification number 116: 116 Sequence characteristics: (A) Length: 282 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: straight line (ii) Molecular type: cDNA (vi) Source: (A) Biology: human (xi) Sequence description: Sequence identification number 116: ACAAAOATGA ACCATTTCCT ATATTATAGC AAAATTAAAA TCTACCCGTA TTGTAATATT 60 GAGAAATGAG ATNAAACACA ATNTTATAAA GTCTACXTAG AGAAGATCAA GTGACCTC AGACTTTACT ATTTTCATAT TTTAAGACAC ATGATTTATC CTATTTTAGT AACCTGGTTG 180 ATACGTTAAA CAAAGGATAA. TGTGAACAGC AGAGAGGATT TGTTGGOAGA AAATCTATGT 240 TCAATCTNGA ACTATCTANA TCACAGACAT TTCTATTCCT TT 2 82 (2) sequence identification number: 1) sequence identification number 30: 2 5 base pairs (B) Type: Nucleic acid (C) Strand type ·· Single strand, printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs (D) Topology: Straight line (ii) Molecular type: cDNA (vi) Source: (A) Biology: Human, (xi) Sequence description: Sequence identification number 117: -116- This paper size is applicable to Chinese National Standard (CNS) A4 specification (210X297 mm) 1228593 Α7Β7 V. Description of the invention (114) ACACATGTCG CTTCACTGCC TTCTTAGATG CTTCTGGTCA ACATANAGGA ACAGGGACCA 60 TATTTATCCT CCCTCCTGAA ACAATTGCAA AATAANAGAA AATA ^ ATGAA ACAATTGCAA 120 AATAAGGCAA AATATATGAA ACAACAGGTC TCGAGATATT GGAAATCAGT CAATOAAGGA 180 TACXOATCCC TGATCAGTGT CCTMTGCAG GATGTGGGAA ACAC ^ ATOAGG TCACCTCTGT 240 GACTGCCCGA GCTTACTGCC TGTAGAOAGT TTCTANGCTQ CAGTTCAGAC AGGGAGAAAT 300 TGGGT 305 (2) SEQ ID information number of 118:. ⑴ Sequence characteristics ... (A) Length: 71 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology · Straight line (ii) Molecular type: cDNA (vi) Source: (A ) Organism: human (xi) sequence description: sequence identification number 118

ACGAA.GGTGT NTGAATCTCT GACGTGGGGA TCTGTGATTC CCGCACAATC TOAGTGGAAA aantcctggc t (2) Information on sequence identification number 119: ⑴ Sequence characteristics: (A) Length · 212 base pairs (B) Type: Nucleic acid Printed (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecular type: cDNA (vi) Source: (A) Biology: Human (xi) Sequence description: Sequence identification No. 119: _ -117- This paper size applies (CNS) A4 specification (21GX297 mm) 1228593 、 Industrial Consumer Cooperatives of Central Standards Bureau of the Ministry of Economic Affairs printed A7 ^ _ B7 V. Description of invention (115) ACTCCGGTTG GTGTCAGCAG CACGTGGCAT TGAACATNGC AATGTGGAGC CCAAACCACA 60 GAAAATGGGG TGAAATTGGCATACACACTA 120 AGTAAGCTGQ CCCTTOTAAT AAAAGAAAAT TGAAAGGTTT CTCACTAAMC GGA? VTTAANT 180 AATGGANTCA AGT ^ NACTCCC AGGCCTCAGC OT 212 (2) Information on sequence identification number 120: (i) Sequence characteristics: (A) Length: 90 base pairs (B) Type: Nucleic acid ( C) strand type: single strand (D) topology: straight line (ii) molecular type: cDNA (vi) source: (A) biology · human (xi) sequence Column description: Sequence identification number 120: ACTCGTTGCA NATCAGGGGC CCCCCAGAGT CACCGTTGCA GGAQTCCTTC TGGTCTTGCC 60 CTCCGCCGGC GCAGAACATQ CTGGGGTGGT 90 (2) Information on sequence identification i2i: ⑴ Sequence characteristics: (A) Length: 218 base pairs (B) Type: Nucleic acid ( C) strand type: single strand (D) topology: straight line (ii) molecular type: cDNA (vi) source: (A) biology: human (read the precautions on the back before reading \ ^! ^ 读 this page)-equipment _

、 1T __- 118- This paper size is applicable to the Chinese National Standard (CNS) six 4 specifications (2l0x297 mm) 1228593 A7 B7 V. Description of the invention (116) (xi) Sequence description: Sequence identification 121: TGTANCGTGA ANACGACAGA NAGGGTTGTC AAAAATGGAG AMTCCTTGAA GTCATTTTGA € 0 GiJATAAGATT TGCTAAAAGA TTTCGGGCTA AAACATGGTT ATTGOGAGAC ATTTCTGAAG 120 ATATNCANGT AftATTANGGA ATGAATTCAT GGTTCTTTTG GGAATTCCTT TACGATNGCC ISO AGCATANACT TCATGfGG Type ATANCAGCTA CGCTTGTA122 Θ (2) sequence: 2 base sequence: 2A sequence : Nucleic acid (C) strand type: single strand (D) topology: straight line '

(ii) Molecular type: cDNA (vi) Source: (A) Organism: human (xi) Sequence description: Sequence identification number 122: TAGGGGTGTA TGCAACTGTA AGGACAAAAA TTGAGACTCA ACTGGCTTAA CCAATAAAGQ 6. CATTTOTTAG CTCATGGAJLC AGGAAGTCGG ATGGTGOGGC ATCTTCAGTG CTGCATGAGl 120 CACCACCCCG GCGGGGTCAT CTGTGCCACA GGTCCCTGTT GACAGTGCGO T 171 (2) Information on serial identification No. 123: ⑴Sequence features: • Printed by the Consumers' Cooperatives of the Central Bureau of Standards of the Ministry of Economic Affairs ------------- ---- Equipment-(Please read the notes on the back page first) Line (A) Length: 76 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecular type: cDNA (vi) Source: -119- This paper size applies Chinese National Standard (CNS) A4 ^ (210X297 male f) 1228593 B7 V. Description of the invention (117) (A) Biology: human (xi ) Sequence description: Sequence identification number 123:

TGTAGCGTGA AGACNACAGA ATGGTGTGTG CTGTGCTATC CAGGAACACA TTTATTATCA TTATCAANTA TTGTGT (2) Information of sequence identification number 124: ⑴ Sequence characteristics: (A) Length: 131 test pairs (B) Type: Nucleic acid (C) Genotype: Single strand (D) Topology Pu Xue: straight line (ii) molecular type: cDNA (vi) source: (A) organism: human (xi) sequence description: sequence identification number 124:

ACCTTTCCCC AAGGCCAATG TCCTGTGTGC TAACTGGGCO GCTGCAGQAC AGCTGCAATT CAATGTGGTG GGTCATATGG AGGGGAGGAG ACTCTAAAAT AGGCAATTTT ATTCTCTTGG TTAAGATTTG T (2) Information on sequence identification 125: ⑴Sequence features: (A) Length printed by the Ministry of Economic Affairs · 432 standard base pairs. (B) Type: Nucleic acid (C) Strand type ·· Single-strand (D) Topology ·· Straight line (ii) Molecular type: cDNA (vi) Source: (A) Biology: Human-120- The paper size is applicable to China Standard (CNS) A4 specification (210X 297 mm) 1228593 A7 B7 V. Invention description (118) (xi) Sequence description: Sequence identification number 125: ACTTTATCTA CTGGCTATOA AATAGATGGT GGAAAATTGC GTTAGCAACT ATACCACTGG 60 CTTGAAAAAG AGGTGATAGC TCTTCAGAGO ACTTGTGGACT CTAGAG TGCTAGCA GAATTTGGAT TAAATGAGGA TGCTOAAGAT 1st 〇 TTGCCTCACG AAACAAAAGT GAAAGAACTG AGAGAAA ^ TT TTCAGGAAAA AAGACAGTGG 240 CTCTTGAAGT ATCAGTCACT TTTGAGAATG TTTCTTAGTT ACTGCATACT TGATCGATCCA 300TGTGTGGGGG GTCTTGCATCTGTGAGAGCA AGAACCACT ATTTTCXAGC CCTCTGTCAG AGCAAACCTC AGTGCCTCTC 420 CTCTTTGCTT GT 432 (2) Information on sequence identification number 126: ⑴ Sequence characteristics: (A) Length: II 2 base pairs (B) Type: Nucleic acid (C) Stock type ·· Single strand

(D) Topology: straight line (ii) Molecular type: cDNA (vi) Source: · (A) Organism: human (xi) Sequence description: Sequence identification number 126: ACACAACTTG AATAGTAAAA TAGAAACTGA GCTGAAATTT CTAATTCACT TTCTAACCAT AOTAAGAATG ATATTTCCCC CCAGGGATCA CCAAATATTt ATAAAAATTT GT H2 (2) Information on sequence identification number 127: ⑴Sequence features: (A) Length: 54 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecular type ·· Source of cDNA (vi): -121-This paper size applies to Chinese National Standard (CNS) A4 specification (21〇χ 297 mm)-^-a --- ^ ---- pack-(Please Read the notes on the back page first

1T • Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs 1228593 A7 V. Description of the Invention (119, Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs (A) Biological: Human (xi) Sequence Description: Sequence Identification 〖27: ACCACGAAAC CACAAACAAG ATGGAAGCAT CAATCCAGTT GCCAAG < ^ ACA GCAG (2) Sequence identification information No. 128 ... Sequence characteristics ... (A) Length: 323 base pairs (B) Type: Nucleic acid (C) Share type: Single strand ( D) Topology: straight line (ii) molecular type: cDNA (vi) source · (A) organism: human (xi) sequence description: sequence identification number 128: ACCTCATTAQ TAATTGTTTT GTTGTTTCA.T TTTTTTCTAA TGTCTCCGCT CTACCAGCTC ACCTGAGATA ACAGAATGAA AATCGAAGGA CAGCCCTCAt tctcct TTCTCTCTGA AGTCTAGGTT ACCCATTTTG GGGACCCATT ATAGGCAATA AACACAGTTC CGAAAGCATT TGGACAGTTT CTTGTTQTGT TTTAG7VATGG TTTTCCTTTT TCTTAGCCTT TTCCTGCAAA AGQCTCACTC (Cyclic sequence: 7VGTCCCTTGC TTGCTCAGtG GTCCTGCGCGCGCGCTCGCGCTCCCGTCGCGCTCGCGCTCGCGCGCGCGCTCGCGCGCGCGCGCTCGCGCTCGCGCGCGCTCGCGCTCGCGCGCGCTCGCGCTCGCGCGCGCGCGCTCGCGCTCGCGCTCGCTCGTCTCG Class 翌: Nucleic acid (0 strands: Single strand (D) topology : Straight line (ii) Molecular type: cDNA (vi) Source: 54 60 120 180 240 300 323 (Precautions for reading the back page first page-binding · Binding-122- This paper size applies to Chinese National Standards (CNS) Specifications (210X297 mm) 1228593 A7 B7 V. Description of the invention (12Q) (A) Biology: Human (xi) Sequence description: Sequence identification No. 129: ACATACATGT GTGTATATTT TTAAATATCA CTTTTGYATC AGTCTGACTT TTTAGCATAC TGAAAACAtag Ctacatcgatg ttggccaatg gataaacaaa gt £ 0 120 180 192 (2) Information on sequence identification number 130: ⑴ Sequence characteristics: (A) Length: 362 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology Pu Xue: Linearization > Molecular Type: cDNA (vi) Source: (A) Organism; Human (xi) Sequence Description: Sequence Identification No. 130:

CCCTTTTTTA TATAATGACG GTTTCCATTG TTCTGTATTC

TGCAGCAGGA GG

TGGAATGAGT CAACAAAAAG TGTTTTGCCG cattttgtta AGCTCTTATT AGCACGTGTG

AOACTOTATG GTGCTOTTTA ATCTTCTGGC ACGCCTGGTA TTQTGGTCAT GGTTGGTTGT

TTTGAANATT GTCCTATGGT TAATCGTGGT QATGTAACCT TAAAATGGCA AAAGCTCTTT

TANCCACAAC TCAC3TTTATG ATCCTCCATG GCTANGAGGC ATTTATGTGC GCTAATCTTA

CTCTTTQACA CCCCTGACAA TTATTAGTAA TAACTTTATA AGCACTTTAT AAAAGTAATG 60 120 180 240 300 3 ^ 0 362 (Read the precautions on the back page first) • Binding, ordering, and threading • Printed by the Central Bureau of Standards, Ministry of Economic Affairs, Consumer Consumption Cooperative (2) Serial Identification Number 131 Information: (i) Sequence characteristics: (A) Length · 332 base pairs (B) Type (C) Single-stranded nucleic acid 123 This paper is in accordance with Chinese National Standard (CNS) A4 regulations (210X297 mm) ) 1228593 A7 B7 V. Description of the invention (121) (D) Topology: straight line (ii) Molecular type: cDNA (vi) Source: (A) Biology: human (xi) Sequence description: Sequence recognition 13 Number 1: CTTTTTGAAA GATCGTGTCC ACTCCTGTGG ACATCTTGTT TTAATGGAGT TTCCCATGCA 60 GTANGACTGG TATGGTTGCA GGTGTCCAGA TAAAAACATT TGAAGAGCTC CAAAATGAGA 120 GTTCTCCCAG GTTCGCCCTG CTGCTCCAAG TCTCAGCAGC AGCCTCTTTT AGGAGGCATC 180 TTCTGAACTA GATTAkGGCA GCTTGTAAAT CTGATGTGAT TTGGTTTATT ATCCAACTAA 240 CTTCCATCTG TTATCACTGG AGAAAGCCCA GACTCCCCAN GACNGGTACG GATTGTGGGC 300 ATANAAGGAT TGGGTOAAGC TGGCGTTGTQ GT 332 (2) SEQ ID information at No. 132: ⑴ sequence special Signs: (A) Length: 322 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecular type: cDNA (vi) Source: (A) Organism: Human (xi) sequence description: Sequence identification number 132: (Read the precautionary page on the back first, and install the line, printed by ACTTTTGCCA TTTTGTATAT ATAAACAATC TTGGGACATT CTCGTGAAAA CTAGGTGTCC 6 0 AGTOGCTAAO AGAACTCGAT TTCAAOCAA- T TCTGAAAGGA AAACCAGCAT GACACAGT ^ AT 120 CTCAAATTCC CAAACAGGGQ CTerGTGGGA AAAATQAQGO AGGACCTTTG TATCTCGOGT 180 tttagcaagt taaaatgaan atgacaggaa aggcttaxtt atcaacaaag AQAAOAGTTG 240 GGATGCTTCT AAAAAAAACT TTGQTAGAGA AAATAGGAAT GCTNAATCCT AGGGAAGCCT 300 GTAACAATCT ACAATTGGTC CA 322 (2) SEQ ID NO's 133 information: ⑴ sEQUENCE cHARACTERISTICS: (A) length : 278 base pairs -124-This paper size applies Chinese National Standard (CNS) A4 gauge (210X 297 mm) A7 1228593 B7 V. Description of the invention (122) (B) Type: Nucleic acid (C) Stock type: Single strand (D) topology: straight line (ii) molecular type: eDNA (vi) source: (A) organism: (Xi) Sequence Description: SEQ ID NO 133:. ACAAGCCTTC ACAAGTTTAA CTAAATTGGG ATTAAtCTTT CTGTANTTAT CTGCATAATT $ 〇CTTGTTTTTC TTTCCATCTG GCTCCTGGGT TGACAATTTG TGGAAACAAG TCTATTGCTA 120 CTATTTAAAA AAAATCACAA ATCTTTCCCT TTAAGCTATG TTNAATTCAA ACTATTCCTG 1Θ0 ctattcctgt tttgtcaaag aaattatatt tttcaaaata tgtntatttg TTTGATGGGT 240 CCGACGAAAC ACTAATAAAA ACCACAGAGA CCAGCCTG 278 (2) Sequence Information identifying No. 134: ⑴Sequence characteristics ... (A) Length: 121 base pairs (B) Type: Nucleic acid (C) Strand type ... Single strand (D) Topology: Straight line (ii) Molecular type: cDNA (vi) Source: (A) Biology: Human (xi) Sequence description: Sequence identification number 134: GTTTANAAAA CTTGTTTAGC TCCATAOAGG AAAC5AATGTT AAACTTTGTA TTTTAAAACA 60 TGATTCTCTG AGOTTAAACT TGGTTTTCAA ATGTTATTTT TACTTGTATT TTGCTTTTGG 120 T 121 (2) sequence identification number 135 Features: -125- This paper size is applicable to Chinese National Standard (CNS) A4 specification (210X 297mm) (Read the precautions on the back page first and then install the _, 1T line. The Central Bureau of Standards, Ministry of Economic Affairs, Consumer Consumption Cooperation Printed by the Agency 1228593 A7B7 V. Description of the invention (123

350 base pairs 4: 35 sets of stems' and LBL ^ cDNA (A) Length (B) Type (C) Strand type (D) Topology (ii) Molecular type (vi) Source: (A) Biology : Human (xi) sequence description: Sequence identification number 135: Read the note on the back of the page.

ACTTANAACC ATGCCTAGCA CATCAGAATC CCTCAAAGAA CATCAGTATA ATCCTATACC ATANCAAOTG GTOAClOGIT AAGCGTGCGA CAAAGGTCAG CTC3GCACATT ACTTGTGTGC aaacttgata cttttgttct aagtaggaac tagtatacag tncctaggan tggtactcca GGGTGCCCCC CAACTCCTGC AGCCGCTCCT CTGTGCCAGN · CCCTGNAAGG AACTTTCGCT CTGCAATTGG CTGAACAAAC GTTTGCTGAG TTCCCAAGGA TGC ^ AAGCCT GGTGCTCAAC TCCTGCGGCG TCAACTCAGT

CCACCTCAAT CAAGCCGTGO GGCATGCTAC 60 120 180 240 300 3S0 • Printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs: 2) Information on sequence identification number 136: (i) Sequence characteristics: (A) Length: 399 base pairs (B) Type : Nucleic acid (C) strand type: single strand (D) topology: straight line (π) molecular type: cDNA (vi) source: (A) organism: human (xi) sequence description: sequence identification number 136

TGTACGGTGA GGTGTGATTG GCAGACTTGT CCTGGCGGCC AAAACTGCAG TCCCAGGAAC GGTGCAGAWG

AOACGACAGA AGTTGCATGG TATCCGAATA NTCCTCGTGT GTCTGCCTTC AANAAGGGAG AGCGAGCCAG CCACAGGTGG AGGCCCAGGG fCAGGTGTNA CCX3GCCAAAG GCCATCCGCA JAAGCAG GATGi

CCAGNTGTTC

CAGGGACAGG GAAAAI ACAG 'GCTTCtTCCT GTGGGTANGT CCTACAGCCA TGCTGTGGT

HAGATAA 3GAAGCC

gcagggccga TGAC3ATGACG CCTGCCTGCC TTTGTGGTGA GACCATAAAA GCATaCCCAC

GGCCAGGGTT tgagcagcct ttggctctga caacnccaag caccaggtgc TGGCGTGATG 60 120 180 240 300 360 399-126- This paper size applies Chinese National Standard (CNS) A4 gauge (210X 297 mm) 1228593 kl B7 V. Description of the invention (124) (2) Sequence identification Information of No. 137: ⑴ Sequence characteristics: (A) Length: 165 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecular type ·· cDNA (vi ) Source: (A) Biology: Human (xi) Sequence description: Sequence identification m number:

ACTGQTGTGG TNGGGGGTGA TGCTGGTGGT ANAAOTTGAN GTGACTTCAN GATGGTGTGT GO GGAGGAAGTG TGTGAACGTA GGGATGTAGA NGTTTTGGCC GTGCTAAATO AGCTTCGGGA 120 TTGGCTGGTC CCACTGGTGO (Number of Sequences: 138) TCACTGTCAT TGGTGGGGTT CCTGT: 1 € 5 ) Type: Nucleic acid (C) Share type: Single strand (D) Topology: Straight line, printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs (ii) Molecular type: cDNA (vi) Source: (A) Biology: human (xi ) Sequence description: Sequence identification number 138:

ACTCACTGGA ATGCCACATT CACAACAGAA TCAGAGQTCT GTGAAAACAT TAATGGCTCC € 0 ttaacttctc cagtaagaat cagggacttg aaatggaaac gttaacaqcc ACATGCGCAA 120 TGCTGGGCAG TCTCCCATGC CTTCCACAGT GAAAGGGCTT GAQAAAAATC ACATCCAATG 180 TCATGTQTTT CCAGCCACAC CAAAAGGTGC TTGGGGTGGA GGGCTGGGGG CATANANGGT 240 CANGCCTCAG GAACCCTCAA OTTCCATTCA GGTTTGCCAC TGTAC ^ TTCC CCATNTTTAA 300 AAAAACtGAT GCCTTTTTTT TTTTTTTTTG TAAAATTC 33B -127 - apply the present paper Scale China National Standard (CNS) A4 specification (210X 297 mm) 1228593 A7 B7 V. Description of the invention (125) (2) Information on sequence identification number 139 · ⑴ Sequence characteristics: (A) Length: 382 base pairs ( B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecular type: cDNA (vi) Source: (A) Biology: Human (xi) Sequence description ·· Sequence identification number 139: GGGAATCTTG GTTTTTGGCA TCTGGTTTGC CTATAGOCGA GGCCACTTTO ACAGAACAAA 60 GAAAGGGACT TCGAGTAAGA AGGTGATTTA CAGCCAGCCT AGTGCCCGAA GTOAAGGAGA 120 ATTCAAACAG ACCTCGTCAT TCCTGGTGTG AGCCTGGTCG GCTCACCGCC TATCATCTGC1 ACTCT GGCCCCTGAT GTCtGTAGTT TCACAQGATG 240 CCTTATTTGT CTTGTACACC CCACAGGCCC CCCTACTTCT TCGGATGTGT TTTTAATAA.T 300 OTCAGCTATG TGCCCCATCC TCCTTCATGC CCTCCGTCCC Ministry of Economic Affairs (Please read the central page on the back page of this page) * Please read this page on the back of the website. Printed by Employee Consumption Cooperative (2) Information on sequence identification number 140: (i) Sequence characteristics: (A) Length · 200 base pairs (B) Type: Nucleic acid (C) Stock type: Single strand (D) Topology Pu Xue: Straight line (ii) Molecular type: cDNA (vi) Source: (A) Organism: Human (xi) Sequence description: Sequence identification number 140: ACCAA ^ CTT ctttctgttg tgttngattt tactataggo gtttnccttm TTCTAAANAT 60 ACTTTTCATT taacancttt tgttaagtgt caggctgcca TACT TGTGTTTGTG TCTTANAGCA TTGGTGAAAT CACATATTTT 180 atattcagca taaaggagaa 200 ___ -128- This paper size applies to Chinese National Standard (CNS) A4 specifications (21 OX 297 mm) Line 1228593 A7 B7 V. Description of the invention (126) (2) Sequence identification number 141 Information: ⑴ Sequence Features: (A) Length : 335 base pairs (B) Class 螌: Nucleic acid (C) Strand type ·· Single strand (D) Topology: Straight line (ii) Molecular type: eDNA (vi) Source: (A) Biology: Human (xi) sequence Description: SEQ ID NO 141: ACTTTATTTT CAAAACACTC ATATGTTGCA AAAAACACAT AGAAAAATAA AGTTTGGTGG 60 GGGTGCTGAC TAAACTTCAA GTCACAGACT TTTATGTGAC AGATTGGAGC AGGGTTTGTT 12 0 ATGCATGTAG AGAAGGCAAA CTAATTTATT AAACAGGATA GAAACAGGCT GTCTGGGTGA 180 AATGGTTCTQ AGAACCATCC AATTCACGTG TCAGATGCTG ATANACTAGC TCTTCAGATG 240 TTTTTCTACC AGTTCAGAGA TNGGTTAATG ACTANTTGCA ATGGGGAAAA AGGAAGATGG 300 ATTCACAAAC CAAGTAATW TAAACAAAGA CACTT 335 ( Read the first note on the back · Impacts on this page) • Equipment ·, printed by the Consumers' Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs (2) Serial ID No. 142: (i) Sequence characteristics: (A) Length ·· 459 Base pairs (B) type: nucleic acid (C) strand type: single strand (D) topology: straight line (ii) molecular type: cDNA (vi) source: < A) organism: human (xi) sequence description: Sequence identification number 142: ACCAGGTTAA TATTGCCACA TATATCCTTT CCAATTGCCG GCTAAACAGA CGTGTATTTA 60 GGG TTGTTTA AAGACAACCG AGCTTAATAT CAAGAGAAAT TGTGACCTTT CATGGAGTAT 120 CTGATGGAQA AAACACTGAG TTTTGACAAA TCTTATTTTA TTCAGATAGC AGTCTGATCA 19〇CACATGGTCC AACAACACTC metric (China National Standards-Accac AC4 AC4) central Bureau of standards portion printed consumer cooperative five employees described (127) the invention TTCAAACATC ATAGCCAATG ATGCCCCGCT TGCCTATAAT CTCTCCGACA TAAAACCACA TCAACACGTC AGTGGCCACC AAACCATTCA GGACAGCTTC CTTAACTGTG AGCTGTTTGA AGCTACCAGT ctgagcacta ttgactatnt serial number of identification information 143 ttttcangct ctgaatagct ctagggatct CAGCAliGGGT GGGAGGAACC AGCTCAACCT TGGCGTANT (2): (i ) Sequence characteristics: (A) Length: 140 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecular type: cDNA (vi) Source: (A) Organism: Human (xi) Sequence description: Sequence identification number 143: ACATTTCCTT CCACCAAGTC AOOACTCCTG GCTTCTGTGG GAGTTCTTAT CACCTGAGGG AAATCCAl ^ C AGTCTCTGCT AGAAAGGAAT AGTGTCACCA ACCCCACCGA T CTCCCTGAa ACC7VTCCGAC TTCCCTQTGT (2) Information of sequence identification number 144 ... Sequence characteristics: (A) Length: 164 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line ( ii) Molecular type ·· eDNA (vi) Source: (A) Biology: Human-130- 0 6 2 5 3 3 4 4 1214 (Please read the precautions on the back page first) National Standard (CNS) A4 specification (2l0X 297 mm) 1228593 A7B7 V. Description of invention (128) (xi) Sequence description · Sequence identification number 144: ACTTCAGTAA CAACATACAA TAACAACATT AAGTOTATAT TGCCATCTTT GTCATTTTCT 60 ATCTATACCA CTCTCCCTTCTCACTACACAACAA ACGCAATTAA TCCATATTTG TTTTCAATAA GGAAAAAAAG ATGT 164 (2) Information on sequence identification number 145 ... Sequence characteristics ... (A) Length ... 303 base pairs (B) Type: Nucleic acid (C) Share type: Single strand (D) Topology ·· Straight (ii) Molecular type: cDNA (vi) Source: (A) Biology: Human (xi) Sequence description: Sequence identification number 145: (Please read the precautions on the back page first) Binding · Order ACGTAGACCA TCCAACTTtG TATTTGTAAT GGCA AACATC CAGNAGCAAT TCCTAAACAA 60 ACTGGAGGGT ATTTATACCC AATTATCCCA TTCATTAACA TGCCCTCCTC CTCAGGCTAT 120 GCAGGACAGC TATCATAAGT CGGCCCAGGC ATCCAGATAC TACCATTTGT ATAAACTTCA 180 GTAGGGGAGT CCATCCAAGT GACAOOTCTA ATCAAAGGAG GAAATGGAAC ATAXOCCCAG 240 TAGTAAAATN TTGGTTAGCT GAAACAGCCA CAAAAGACTT AGCGCCGTGG TGATTACCAT Bureau of Standards staff consumer cooperative economic printed portion 300 CAA 303 (2) SEQ ID 146 Number information: ⑴ Sequence characteristics: (A) Length: 327 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecular type: cDNA (vi) Source ： LINE '-131 · This paper size applies the Chinese National Standard (CNS) A4 Orange (210X 297 mm) 1228593 A7 B7 V. Description of the invention (129) (A) Biological: Human (xi) Sequence description: Sequence identification 146 Number: ACTC3CAGCTC AATTAGAAGT GGTCTCTGAC TTTCATCANC TTCTCCCTGG GCTCCATGAC ACTGGCCTGG AGTGACTCAT TGCTCTGGTT GGTTGAGAGA GCTCCTTTGC CAACAGGCCT 120

CCAAGTCAGG GCTGGGATTT GTTTCCTTTC CACATTCTAG CAACAATATG CTGGCCACTT 1BO CCTGAACAGG gagggtggga ggagccagca TGGAACAAGC TGCCACTTTC TAAAGTAGCC 240 AGACTTGCCC CTGGGCCTGT CAGTAG: C # TAG: GA TGTGGAGGATGGAGAT Base pair (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecular type: CDNA (vi) Source: (A) Biology: Human (xi) Sequence description: Sequence recognition No. 147: ACATtGTTTT TTTGAGATAA AGCATTGANA GAGCTCTOCT TAACGTGACA CAATGGAAGG 60 ACTGGAACAC ATACCCACAT CTTTGTTCTG AGGGATAATT TTCTQATAAA GTCTTGCTGT 12 0 ATATTCAAGC ACATATGTTA TATATTATTC AGTTCCATGT TTATAGCGTA GTT 173 sequence number: 178 base sequence: Pair (B) Type: Nucleic Acid (C) Strand Type: Single Strand (D) Topology: Straight

(ii) Molecular type: cDNA -132- This paper size applies to Chinese National Standard (CNS) A4 gauge (210X 297 mm) (Please read the precautions on the back page first) —Package-Too-δ, Economy, 郅Printed by the Central Procurement Bureau for Employee Cooperative Cooperation 1228593 A7 B7 V. Description of Invention (130 (vi) Source ··

(Xi) sequence ACAA.CCACTT ATGGGATATA GCCCTACTAC GTGGTCCTAO NCCANCCCAC TAQATTATNT CACCACTGGT CCAGGCACAG

Description: Sequence recognition TATCTCATCG AATTTTTAAO TTATTTGATG CTCCATTTCA CTGCTGCAAT AATCACATTC TGGCCATCAG TCCANGCCTO CTCAGCGACC CCATCCTCTT CCAAATTCAG TCAATTAAGT AAGCCTTCTC CAGCCAACAC GCTACCTCAt CTTCACAATC

No. 148: CCAAACTCAC TCACACATAT CCTTCCTGTC CACCTTGAGC ACACAGCTAC TACTATTAAC ACACACACAC ACCCCTTTAA

TCACTGTGCC ATGAATAATA CTGACCCTGA CCTTGAGCTC CTCCTTGCTC ACTCTACCCG ACACNCACAC TTACCATGCT

TTTCTATCCT CACTCATACT AGCCATTGGG CATTGCTCAC TCTAACCCCA ACATGTCCA < 3 ACACACATAT ATGGTGG ¢ 0 120 1B0 240 300 360 420 477 (2) Information on sequence identification number 149: ⑴ Sequence characteristics: (A) Length: 207 base pairs (B) Type: Nucleic acid (C ) Strand type: single strand (D) topology: straight line (ii) molecular type: cDNA (vi) source: (A) organism: human (xi) sequence description: sequence identification number 149 ^ 0 X20 180 207

ACAQTTGTAT TATAATATCA AGAAATAAAC TTGCAATGAG AGCATTTAAQ AOGGAAGAAC TAAGGTATTT TAGAGAGCCA AGGAAGGTTT CTGTGGGGAG TGGGATQTAA GGTGGGGCCT GATQATAAAT AAOAGAGAGAGCACAGCAGCACAGGAT : (A) Length · 111 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line -133- This paper size applies Chinese National Standard (CNS) A4 specification (210X 297 mm) 1228593 V. Description of the invention (131) (ii) Molecular type: cDNA (vi) Source: (A) Biology: human (xi) Sequence description: Sequence identification number 150: ACCTTGATTT CATTGCTGCT CTGATGGAAA CCCAACTATC TAATTTAGCT AAAACATGOG 60

CACTTAAATG TGGTCAGTGT TTGGACTTGT TAACTANTGG CATCTTTGGG T HI (2) Sequence identification number 151: (i) Sequence characteristics · (A) Length: 196 base pairs (B) Type: Nucleic acid (C) Share type: Single strand (D ) Topology: Straight line (ii) Molecular type: cDNA (vi) Source: (A) Biology: Human (xi) Sequence description: Sequence identification number 151: AGCGCGGCA.G GTCATATTGA ACATTCCAGA TACCTATCAT TACTCGATGC TGTTGATAAC € 〇AQCAAGATGO OTTTGAACTC AGGGTCACCA CCAGCTATTO GACCACACT 12 0

GGAXACCAAC CGOAAAACCC CTATCCCGCA CAGCCCACTG TGCTCCCCAC TGTCTACGAQ XSQ GTGCATCCGG CTCAGT 196 (2) Information of sequence identification number 152: (i) Sequence characteristics: (A) Length: 132 base pairs (B) Type: Nucleic acid (C) Stock type: Single strand (D) Topology: Straight Line

(ii) Molecular type: cDNA, 134- This paper size applies to Chinese National Standard (CNS) A4 (210X 297 mm) (Please read the notes on the back first

Γ • Printed by the Consumers' Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs Printed by the Consumers ’Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs 1228593 7 A7 V. Description of the Invention (132) (vi) Source: (A) Biological: Human (xi) Sequence Description: Sequence Identification number 152:

ACAGGACTTT CACATGTAA.G AAGGGAGAAA TTCCXAAATG TAGGAGAAAQ ATAACAGAAC CTTCCCCTTT TCATCTAGTG GTGGAAACCT GATGCTTTAT GTTOACAGGA ATAGAACCAG GAGGGAGTTT 0T (2) Information on sequence identification number 153. ⑴Sequence characteristics: (A) Length: 285 base pairs Strand type: single strand (D) topology: straight line (ii) molecular type: cDNA (vi) source: (A) organism; human (xi) sequence description: sequence identification number 153:

ACAANACCCA NGANAGGCCA CTGGCCGTGG TGTCATGOCC TCCAAACATO AAAGTGTCAG cttctgctct tatgtcctca tctgacaact ctttaccatt tttatcctcg ctcagcagga

GCACATCAAT AAAGTCCAAA GTCTTCjGACT TGGCCTTGGC TTGGAGGAAG TCATCAACAC CCTGGCTAGT GAGGGTGCGG CGCCGCTCCT GGATGACGGC ATCTGTGAAG TCGTGCACCA gtctggaggc cctgtcgaag: nucleic acid sequence: 333 sequence: gaatt2 (Gat) Stock type: Single (D) Topology: Straight-135- This paper size is applicable to China National Standard (CNS) A4 specification (210X297 male f) S20s = 40

1228593 A7 B7 V. Description of the invention (133) (ii) Molecular type: cDNA (vi) Source: (A) Biology: human (xi) Sequence description: Sequence identification number 154: ACCACAGTCC TGTTGCGCCA GGGCTTCATG ACCCTTTCTG TGAAAAGCCA TATTATCACC 60 ACCCCAAATT TTTCCTTAAA. TATCTTTAAC TGAAGGGGTC AGCCTCTTGA CTGCAAAGAC 120 CCTAAGCCGG TTACACAGCT AACtCCCACT GGCCCTGATT TGTGAAATTG CTGCTGCCTG l $ 〇ATTGGCACAG GAGTCGAAGG TGTTCAGCTC CCCTCCTCCG TGGAACCAGA CTGTGATTTQ 240 AGTTTCACAA ATTCTCGGGC CACCTCGTCA TTGCTCCTCT GAAATAAAAT CCGGAGAATG 300 OTCAGGCCTG TCTCATCCAT ATGGATCTTC CGG 333 (2) information 155 of SEQ ID NO: (i) sequence fEATURE: (A ) Length · 308 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecular type: cDNA (vi) Source: (A) Biology: Human (xi ) Sequence description: Sequence identification number 155: It is necessary to read the precautions on the back of this page-installation. 、 Printed by ACTGGAAATA ATAAAACCCA CATCACAC3TQ TTGTGTCAAA GATCATCAGG GCATGOATGG GO GAAAGTGCTT TGGGAACTGT AAAQTGCCTA ACACAtGATC GATGATTT TT OTTATAATAT 120 TTGAATCACG GTGCATACAA ACTGTCGTGC CTGCTCCTCC TGQQCCCCAG CCCCAGCCCC iaATCACAQOTC ACTGCTCTGT TCATCCAGOG COAOCATGTA GTGC3CTGATT CTTCTTGOA sequence: 300 GCTTTTAGCC TCCANAAGTT TCTCTGAAGCGCTACATGCAGCAAA · 295 base pairs (B) Type: Nucleic acid -136- This paper size applies Chinese National Standard (CNS) A4 standard orange (210X297 mm) 1228593 A7 B7 V. Description of the invention (134) (C) Stock type: single (D) Topology: Straight line (ii) Molecular type: cDNA (vi) Source: (A) Biology: Human (xi) Sequence description: Sequence identification number 156: ACCTTGCTCG GTGCTTGGAA CATATTAGGA ACTCAAAATA TGAGATGATA ACAGTGCCTA 60 TTATTGATTA CTGAGAGAAC TGTTAGACAT TTAGTTGAAG ATTTTCTACA 12 0 GAATAGGAGA ttatgtttgg ccctcatatt ctctcctatc ctccttgcct CATTCTATGT 130 CTAATATATT CTCAATCAAA TAAGGTTAGC ATAATCAGGA AATCGACCAA ATACCAATAT 240

AAAACCAGAT GTCTATCCTT iAGATTTTCA AATAGAAAAC AAATTAACAG ACTAT 29S (2) Information of sequence identification number 157: ⑴ Sequence characteristics:. (A) Length: 126 base pairs (B) Type: Nucleic acid (C) Share type: Single strand (D) Topology Pu Xue: straight line (ii) molecular type: cDNA (vi) source: (A) organism: human (xi) sequence description: sequence identification number 157: ACAAOTTTAA ATAGTGGTQT CACTGTGCAT GTGCTGAAAT GTGAAATCCA CCACATTTCT 60, printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs GAAGAGCAAA ACAAATTCTG TCATGTAATC TCTATCTTC3C3 GTCaTQGGTA TATCTGTCCC 120 CTTAGT 126 (2) Information on sequence identification number 158: ⑴ Sequence characteristics: (A) Length: 442 base pairs (B) Type: Nucleic acid-137- This paper is in accordance with Chinese national standards ( CNS) A4 specification (210X 297 mm) 1228593 A7 B7 V. Description of the invention (135) (C) Strand type: single strand (D) Topology: straight line (ii) Molecular type: cDNA (vi) Source: (A) Organism: Human (xi) Sequence description: Sequence identification number 158: ACCCACTGGT CTTGOAA ^ CA CCCATCCTTA ATACGATGAT TTTTCTGTCG TGTGAAAATG GO AANCCAGCAG GCTGCCCCTA GTCAQTCCTT CCTTCCAGAG AAAAAGMAT TT GAGAAAGT 120 GGGTGGGTAA TTCAGCATTA ATTTCCTCGC CCAAACTCTC TGAGTCTTCC CTTAATATTT 180 CTOGTGGTTC TGACCAAAGC AGGTCATGGT TTGTTGAGCA TTTGGGATCC CAGTGAAGTA 24 ΰ NATGTTTGTA GCCTTGCATA CTTAGCCCTT CCCACGCACA AACGGAGTGG CAGAGTGGTG 300 CCATiCCCTGT TTTCCCAGTC CACGTAGACA GATTCACAOT GCGGAATTCT GGAAGCTGGA 3 60 NACAGACGGG CTGTTTGGAG AGCCGGGAGT CTGAGANGC3A CATGAGGGCC TCTGCCTCTG Λ20 TGTTCATTCT CTGATGTCCT GT 442 (2) SEQ ID NO 159 Information: (i) Sequence characteristics: (A) Length: 498 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecular type: cDNA (vi) Source: 'Printed by the Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs (A) Biological: Human (xi) Sequence Description: Sequence Identification No. 159: ACTTCCAGGT AACGtTGTTG TTTCCOTTOA GCCTGAACtG AXGGGTGACO TTGTAGOTTC 60 TCCAACAAGA ACTGAGGTCGCTGGCTGOT AGGGAAGAGT OCTQTTCCACGCTGGCTGGCGCTGTG 180 GTGTGTTGTT GGANTTGAGC TCGGGCX3GCT GTGGTAGGTT GTGGGCTCrC CAACAGGGGC 240 TGCTGTGGTG CCGGGANGTG AAN GTGTTGT GTCACTTGAG CTTGGCCAGC TCTGGAAAGT 300 ANTANATTCT TCCTGAAGGC CAGCGCTTGT GGAGCTGGCA NGGGTCANTG TTGTGTGTAA 350 CGAACCAGTG CTGCTGTGGG TGGGTGTANA TCCTCCACAA AGCCTGAAGT TATGGTGTCN 420 TCAGGTAANA ATGTGGTTTC AGTGTCCCTG GGCNGCTGTG GAAGGTTGTA NATTGTCACC 4Θ0 AAGGGAATAA GCTGTGGT 498 -138- This paper scales applicable Chinese National Standard (CNS) A4 gauge station (210X297 mm) 1228593 A7 B7 V. Description of the invention (136) (2) Information of sequence identification number 160: (i) Sequence characteristics (A) Length: 380 base pairs (B) Type · Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecular type: cDNA (vi) Source: (A) Biology · Human (xi) Sequence description: Sequence identification number 160: ACGTGCATCC AGCTTCCCTQ CCAAACTCAC AAGGAGACAT CAACCTCTAO ACAGGGAAAC 60 KGCTTCAGGA TAGTTCCAGG AGACAGAGCC ACCAGCCTA TAAA 12 0 GQAGCATGGC ATAOAGGAAG CTGANAAATG TGGGGTCTGA GGAAGCCATT TGAGTCTGGC 180 CACTAGACAT CTCATCAGGC ACTTCJTGTGA AGAGATGCCC CATGACCCCA GATGCCTCTC 240 CCACCCTTAC GTCCATCTCA CACACTTGAG CTTTCCAGTG TGTATAATTC TAACATGC AATG GCAGTTTGAC CGAACGTGTT CACAACGQTA GAGGCTGATT TCTT ^ -CGAAA 360 CTTGTAGAAT GAAOGGTGQA 3fl0 (2) Information on sequence identification number 161: (i) Sequence characteristics: (A) Length: 114 base pairs (B) Type: Nucleic acid. Central Ministry of Economic Affairs Printed by the Consumer Bureau of Standards Bureau (C) Stock type: Single strand (D) Topology: Straight line (ii) Molecular type: cDNA (vi) Source: (A) Biology: Human (xi) Sequence description: Sequence identification number 161 ： -139- This paper size applies the Chinese National Standard (CNS) A4 specification (210X 297 mm) A7 B7 1228593 V. Description of the invention (137) ACTCCACATC CCCTCTGAGC AGGGGGTTGT CGTTCAAGGT GTATTTGGCC TTGCCTGTCA CACTGTCCAC TGGCCCCTTA TCCACTTGGT GCTTGATCCCTCGCTCAATCACC Information of No. 162: ⑴ Sequence characteristics: (A) Length: 177 base pairs (B) Type · Nucleic acid (C) Strand type · Single strand (D) Topology: Straight line (ii) Molecular type: cDNA ( vi) Source: (A) Biology: Human (xi) Sequence description: Sequence identification number 162: ACTTTCTGAA TCGAATCAAA TGATACTTAQ TGTAGTTTTA ATATCCTCAT ATATATCAAA 60 GTTTTACTAC TCTGATAAIT: TTGTAAACCA GGTAACCAGA ACATCCAGTC ATACAGCTTT 120 TGGTGATATA TAACTTGGCA ATAACCCAGT CTGGTGATAC ATAAAACTAC TCACTGT 177 (2) Information of sequence identification number 103: ⑴ Sequence characteristics: (A) Length: 137 base pairs (B) Type: Nucleic acid · (C) Share type: Single strand ( D) Topology: straight line (ii) molecular type: cDNA (vi) source: (A) organism: human (xi) sequence description: sequence identification number 163: CATTTATACA GACAGGCGTG AAGACATTCA CGACAAAAAC GCGAAATTCT ATCCCGTGAC 60 CANAGAAGGC AGCTACGGCT ACTCCTACAT CCTCGCGTGG GTGGCGTTCG CCTGCACC ATGATGT 137 • 140-This paper size applies to Chinese National Standard (CNS) A4 gauge (210X 297 mm) (Read the precautions on the back before reading ^^ Write this page) Printed by the consumer cooperative 1228593 ΑΊ Β7 V. Description of the invention (138 (2) Information on sequence identification number 164: (i) Sequence characteristics · (A) Length: 469 base pairs (B) Type: Nucleic acid (C) shares Type: Single strand (D) Topology: Straight line (ii) Molecular type: cDNA (vi) Source: (A) Biology: Human (xi) Sequence description: Sequence identification number 164: Please read first Back · Face Winter i Things P This Page Pack

CTTATCACAA TGCAATGCAT TGCATGGATC GAGACATGCA GGTTATGACA GTGGAGAAGA TCTAGTAGGC GATTGTGTAG

TGAATOTTCT CATGCTATTT TCAAAGGAAA CTTGCTACGA AAGACAACTG AGGACCCAAA, ACAGGGGTCC CCATCCCTAT

CCTGOGCAGC CATACCTAAT CAAACAGCCA AACAGAAATT CCAAAGAATC AAAGACCTGT CAGGCCAGGC CAGTAAAAAG

GTTGTGATCT GAGGGAGTTC ATAAACTCGG TCATGTTGCA TTCAAGAAGG TCTGTCAGTG CTCATTCTCC ATNTTTGAGC

TTGCCACCTT CAGGAGATTC AGTGGCAGAC CCCTTOTTTG AGGACTGCAA AATGGATAAT TCTGGCCTCT AAACACTTT

.CTTTA .GGAAA CGTGAC AACCAl TGACAACTGT TACACCTGTG GTATATCOTG ctaatgtgct aatagtcaat 60 120 180 240 300 360 420 469 Printing • Printed by the Consumers' Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs (2) Information on serial identification number 165: (i) Serial characteristics: (A) Length: 195 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecular type: cDNA (vi) Source: (A) Biology: Human (xi) sequence Description: Sequence identification number 165: 141 This paper size is in accordance with Chinese National Standard (CNS) A4 (210X 297 mm) 1228593 A7 B7 V. Description of invention (139 printed by ACAGTTTTTT ATANATATCQ ACATTGCCGG CACTTGTGTT ATCCGCTGTC ATCCACTATT CCTTGGCTAG AGTAAAAATT TGCAGGCCGC CCGCCCGTAG TTCTCGTTCC AGTCGTCTTG TCCTTCTGAGA TGAGT (6) Poverty: (i) Sequence characteristics: (A) Length: 383 base pairs (B) Type: Nucleic acid (C) Stock type: Single strand (D) Topology: straight line (ii) Molecular type: cDNA (vi) Source: (A) Organism: human (xi) Sequence description: Sequence identification number 166: ACATCTTAGT AGTGTGGCAC ATC AGGGGGC CATCAGGQTC CGAGGTCGGA GTCCACACCA CCGGTGTAGG TGTGGTCAAT TTGQAGAAQG OATATGCTGC ACACkCATGT CCACAAAGCC TTTGCAGACC AGOCTGAGCA AGGGGCGQAT GTTCAGCTTC GATGCCAAGC TCGTCTANGO TCCGTGGGAA GCTGGTGTGC GANGATCTTA TAAAGAGGCT CCNAGATAAA CTCCACGAAZV NGGGGCCTTT TTGGTGAACT TTG (2) serial number of identification information 167: (i) SEQUENCE CHARACTERISTICS ·· (A) Length: 247 bases Base pair (B) Type: Nucleic acid (C) Strand type · Single strand (D) Topology: Straight line (ii) Molecular type: cDNA (vi) Source: (A) Biology: Human

CAGTTTCATA AAGCTGGTGG ATTOTTATAG CCOATGTCCC GCACACAGGG TGCCAGGACT

ACAGTCACTG CTTGGGCTTG TGTGAACTCG AJGCTCCTCCT ACNTCACCTA CTTCTCTGGG

ATAGCCTCGC GCGCCCACCT CCAAAGAATT TGGTCAGGTG CAACCTGGGC AC3GTGGTAGT

60 120 180 13S Please read the back-to-back Ϊ. Matters on this page 60 120 180 240 300 300 360 3 63 Order-142- This paper size applies to China National Standard (CNS) A4 gauge (210X 297 mm) 1228593 A7 ______ B7 V. invention is described in (140) (xi) sequence Description: SEQ ID NO 167: ACAGAGCCAG ACCTTGGCCA TAAATGAANC AGAGATTAAG AGTAAACCCC AAGTCGANAT 60 TGGAGCAGAA ACTCGAGCAA GAAGTGGGCC TGGGGCTGAA GTAGAGACCA AGGCCACTGC 120 TATANCCATA CACAGAGCCA ACTCTCAGGC CAAGGCNATG GTTGGGGCAG ANCCAGAGAC 180 TCAATCTGAN TCCAAAQTGG TGGCTGQAAC ACTGGTCATG ACANAGGCAG TGACTCTGAC 240 TGANGTC 247 ( 2) Information on sequence identification number 168: (i) Sequence characteristics: (A) Length: 273 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology ·· Straight line (ii) Molecular type: cDNA (vi) Source: (A) Biology: human (xi) Sequence description: Sequence identification number 168 ACTTCTAAGT TTTCTAGAAG TGGAAGGATT GTANTCATCC TOAAAATGGG TTTACTTCAA 60 AATCCCrCAN CGTTGTTCTT CACNACTGTJTAG TCCACTACA GTGTCATGTT TCCACAAAGGGACTCTCTCTGCT GTGGGC 160 AATTCCCAAC TTCCTTGCCA CAAGCTTCCC AGGCTTTCTC CCCTGGAAAA OTCCAGCTTG 24 0 AGTCCCAGAT ACACTCATGG GCTGCCCTGG GCA 273 (2) Information on sequence identification number 169: ⑴Sequence characteristics · (A) Length: 431 base pairs, printed by the Consumers' Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs t (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecular type: cDNA (vi) Source: -143- Standards are applicable to Chinese National Standard (CNS) A4 regulations (2l 〇x 297mm 122593 ΑΊ B7 V. Description of the invention (141) (A) Biology: human (xi) Sequence description: Sequence identification number 169: ACAGCCTTGG CTTCCCCAAA CTCCACAGTC TCAGTGCAGA AAGATCATCT TCCAGCAGTC 6Q AGCTCAGAG ACGGQTCAAA.G GATGTGACAT CAGTAGTC ACCTAGAG AC ATGACCCCCC ATACTTCCTC AAAGGCTGTG GTAAGTTTTG CACAGGTGAG 1Θ0 GGGAGCAGAA AGGGGGTANT TACTGATGGA CACCATCTTC TCTGTATACT CCACACTGAC 240 CTTQCCATGG GCAAAGGCCC CTACCACGG ACTCAGAC ACCACATAC TTCTGGGGGC CATCAGCTGC 420 TCGAACACTG A 431 (2) Information on sequence identification number 170 ... Sequence characteristics: (A) Length: 266 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology ·· Straight line (ii) Molecular type: cDNA (vi) Source: (A) Biology: human (xi) Sequence description: Sequence identification number 170: ACCTGT〇 < 3GG TGGGCTGTTA TGCCXGTGGG GGCTGCTGAA AGGGAGTTCA GAQGTGGAGC 60 TCAAGGAGCT CTGCAGGCAT TTTGCCAANG CTCTCCANAG CANTAGACT ^ 0 CCCCGCTAQA AAGACACOAG ATTGGAGtCC TGGGAGGGGG AGTTGGGGTQ GGCATTTGAT 18〇GTATACTTGT CACCTGAATG AANGAGCCAG AGAGGAANGA GACGAANATG ANATTGGCCT 240 TCAAAGCTAQ GGGTCTGGCA GGTGOA 266, printed by Department of Economics and Information Bureau Central Bureau of Standards and Information Bureau Number: 171. ·· 1248 base pairs (B) Type: Nucleic acid (C) Strand type: Single-144 ㈣ This paper size applies the Chinese National Standard (CNS) A4 regulations (210X 297 public ^ 7 1228593 A7 B7 V. Description of the invention (142 (D) Topology: Linear (H) Molecular Type: cDNA (vi) Source: (A) Organism: Human (xi) Sequence Description SEQ ID NO 171:

GGCAGCCAAA CTGGTCATQa

TCAGCCGGAC

CACAGTCTTO

CGGCACCCAG

GAATCCGtGT

GCGGGGAACT

GTGCTGCAGT

CCGCTGTACC

AACGGTGACT

GGAAAAGCCC

ACTGAGTGGA

ATTGACCCCC

CCCTCAGGCC

CCCAGCCCCT

CCAGGAGTCC

CXCAGACCGA

CCAACCCNTC

GCQGTCCAAT

AACCTTACCA

AAGAGAAGNG

TCATAAACGG

WVAACGAATT

ACTGTTTCCA

AGGCCGACCA

AGTACAACAG

CCGAGTCTGA

CTTGCGTCGT

GCGTGAACGT

ACCCCAGCAT

CTGGGGQGCC

CGTGtGGCCA

TAGAGAAAAC

AAATACATCC

CAGGAGTCCA

CCTCCCTCAO

AGCCCCTGCT

GGGGTCCAGG

ATTCCCCAGA

GCCACCTAGA

GTTGGTTTTT caaaaaaaaa

CGAGGACTGC

OTTCTGCTCG

GAAQTGAGTG

AGAGCCAGGG

ACCCTTOCTC

CACCATCCGO

TTCTGGCTGG

GTCGGTGGTG

GTTCTGCGCC

CCTGATCTGC

AGTTGGCGTO

CGTCCAGQCC

TGCGGAAGGA

GGCCCCCAGC

AGCCAGGAGT

CCCTCAGACC

CCCCCAACCC

CCCAGAGOTC

CTNTCCCTGT

CATTTTTNGT

AOCCCGCACT

GGCOTCCTGG

CAGAGCTCCT

AGCCAGATGG

GCTAACQACG

AGCATCAGCA

GGTCTGCTGG

TCTGAGGAGG

GGCGGAGGGC aacgggtagt

CCAGGTGTCT

AGTTAACTCT

ATtCAGGAAT

CCCTCCTCCC

CCAGACCCCC

CAGGAGTCCA ctcctoccto caggtcccag

ACACAGTGCC

CCCTTTCCCC

CGCAGGCCTQ

TGCATCCGCA

ACACCATCGG TGGAQGGCAa

TCATGCTCAT

TTGCTTCGCA

CGAACGGCAG

TCTGCAGTAA

AAGACCAGAA

TGCAGGGCCT

ACACCAACCT

GGGGAGTGGG

ATCTGTTCCC

TCAAACCAAG

CAGCCGGTCC

GACCCCCCAG

AGACTCAGAG

CCCCTCNTCC

CCCTTGTGGC

TAGATCCAGA

GCAGGCGGCA

GTGGGTGCTG

GCTGGGCCTG

CCTCTCCGTA

CAAGTTGGAC

OTGCCCTACC

AATGCCTACC

GGTCTATGAC

GGACTCCTGC

TGTGTCTTTC

CTGCAAATTC

AACCCATGAA

AGCCCCTCCT

GGTACAGATO

TCCCTCAGAC cccctcctcc

GTCCAAGCCC

CTCAGACCCA

ACGTTGACCC

AATAAAGTTT eo 120 180 240 300 360 420 480 540 600 Swallow 60 720 7 B0 840 900 960 1020 1080 1140 1200 1248 Please read the back and the above precautions P Binding on this page • Printed by the Central Standards Bureau of the Ministry of Economy <Printed by Industrial and Consumer Cooperatives (2) Information of sequence identification number 172: ⑴Sequence characteristics: (A) Length: 157 amino acids (B) type · · amino acids (C) strand type: single strand (D) topology: straight line (ii) ) Molecular type: Protein (vi) Source: (A) Biology: Human (xi) Sequence description: Sequence identification No. 172:, 145 This paper size applies Chinese National Standard (CNS) A4 standard orange (210X 297 mm) 1228593 kl B7 V. Description of Invention (143

Met VaX Qlu Ala Ser Leu Ser Val Arg His Pro Glu Tyr Asn. Arg Pro 15 10 15 Leu Leu Ala Asn Aep Leu Met Leu lie Lys Leu Aep Glu Ser Val ser 20 25 30 Glu Ser Asp Thr lie Arg fier lie Sex * lie Ala Ser Gin Cys Pro Thr 3S 40 45 Ala Gly Asn Ser Cya Leu Val Ser Gly Trp Gly Leu Leu Ala Asn Gly 50 55 ¢ 0 Arg Met Pro Thr Val Leu Gin Cys Val Asn VelI Ser Val Val Ser Glu 65 70 75 80 Glu Val cys Ser Lys Leu Tyr Asp pro Leu Tyr His Pro Ser Met Phe 85 90 95 Cys Ala Gly Gly Gly Gly Gin Xaa Gin Xaa Asp Ser Cys Asn Gly Asp Ser 100 105 X10 Gly Gly Pro Leu lie Cya Asn Gly Tyr Leu Gin Gly Leu Val Ser Phe US 120 125 Gly Lys AIa Pro Cy3 Gly Gin V at 1 Gly Val Pro Gly Val Tyr Thr Asn 130 135 140 Leu Cys Lys Phe Tixr Glu Trp lie Glu Lys Thr Val Gin Ala Ser 145 ISO 155 Please read the back, Item i on this page Binding information printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs (2) Serial ID No. 173: ⑴Sequence features: (A) Length: 1265 base pairs (B) Type: Nucleic acid (C) Stock Type: Single Stock (D) Topology: Straight (Ii) MOLECULE TYPE: cDNA (vi) Source: (A) Biological · person -146-

This paper scale applies to Chinese National Standard (CNS) A4 regulations (210X297 male iT 1228593 A7 B7 V. Description of invention (144) (xi) Sequence description: Sequence identification number 173: GGCAGCCCGO ACTCGCAGCC CTQGCAGGCG GCACTGGTCA TGGAAAACGA ATTGTTCTGC 60 TCGGGCGTCC TGGTGCATCC CTAGGCGGGGCG CCAGAACTCC 120 TACACCATCG GGCTGGGCCT GCACAGTCTT GAGGCCGACC AAGAGCCAGG GAGCCAGATG 190 GTGGAGGCCA GCCTCTCCGT ACGGCACCCA GAGTACAACA GACCCTTGCT CGCTAACGAC 240 CTGA.TGCTCA TCAAGTTGGA CGAATCCGTO TCCGAGTCTG ACACCATCCG GAGCATCAGC 3 00 ATTGCTTCGC AGTGCCCTAC CGCGGGGAAC TCTTGCCTCG TTTCTGGCTG GGGTCTGCTG 360 GCGAACGGTG AGCTCACGGG TGTGTC3TCTG CCCTCTTCAA GGAGGTCCTC TGCCCACTCG 420 CGGGGGCTGA CCCAGAGCTC TGCGTCCCAG GCAGAATGCC TACCGTGCTG CAGTGGGTGA 480 AOGTGTCGGT GOTQTCTGAG GAGOTCTGCA GTAAQCTCTA TGACCCGCTQ TACCACCCCA 540 GCATQTTCTG CGCCGGCGGA GGGCAAGACC AGAAGGACTC CTGCAACGGT GACTCTGGGG ¢ 00 GGCCCCTGAT CTGCAACGGG TAGTTGCAGG CSCCTTGTGTC TTTCGGAAAA GCCCCGTGTO 660 GCCAAGTTCT OCTAC AGGGTCCA GGCCAGTTAA CTCTGGGGAC TGGGAACCCA TGAAATTGAG CCCCAAATAC 780 ATCCTGCGOA AGGAATTCAG GAATATCTGT TCCCAGCCCC TCCTCCGTCA GGCCCAjGGAG 840 TCCAGGCCCC CAGCCCCTCC TCCCTCAAAC CAAGGGTACA GATCCCCAGC CCCTCCTCCG 900 TCACACCCAG GAGTCCAGAC CCCCCAGCCC CTCCTCCCTC AGACCCAGGA GTCCAOCCCC 960 TCCTCCNTCA GACCCAGGAG TCCAGACCCC CCAGCCCCTC CTCCCTCAGA CCCAGGGGTT 1020 GAGGCCCCGA ACCCCTCCTC CTTCAGAGTG AGAGGTCCAA GCCGCCAACC CCTCGTTCCC 10Θ0 CAGACCCAGA GGTNNAGGTC CCAGCCCCTC TTCCNTCAGA CCCAGNGGTC CAATGCCACC 114 0 TAGATTTTCC CTONACACAG TGCCCCCTTG TGGNANQTTG ACCCAACCTT ACCAGTTGGT 1200 TTTTCATTTT TNQTCCCTTT CCCCTAGATC CAGTJ ^ TAAA GTTTAAGAOA NGNQCAAAAA 1250 AAAAA 1265 (2) Sequence identification number 174: (i) Sequence characteristics: (A) base pair (C) Stock type: Single stock (D) Topology: True line • Printed by a member of the Central Standards Bureau of the Ministry of Economic Affairs and Consumer Cooperatives (ii) Molecular type: cDNA (vi) Source: (A) Biology: Human (xi) Sequence description : Sequence ID 174:

GOTCAGCCGG ACACTGTTTC CAGAAGTQAC3 TGCAGAQCTC CTACACCATC GGGCTGGGCC TGCACAGTCT TGAGGCGGAG CAAGAGCCAG GOAGCCAGAT GGTGGAGGCC AGCCTCTCCG 120 TACX3GCACCC AGAGTACAAC AGACCCTTGC TCGCTAACGA CCTCATQCTC ATCAAJBTTGO Xfi〇ACGAATCCGT GTCCGAGTCT GACACCATCC GGAGCATCAO CATTGCTTCG CAGTGCCCTA 240 CCGCGGGOAA CTCTTQCCTC GTTTCTGGCT GGGGTCTGCT GGCGAACGGT ΟΑσΟΤΟΑΟΟα 300 GTGTGTO-rCT GCCCTCTTCA AGGAGGTCCT CTGCCCAGTC GCGGGGGCTG ACCCAGAGCT 360 CTGCX5TCCCA GGCAGAATGC CTACCGTGGT GCAGTGCGTG AACGTOTCGG TGGTGTCTGA 420 NOAGOTOTGC ANTAAGCTCT ATGACCCGCT OTACCACCCG ANCATGTTCT GCGCCGGCGO 4B0 -147-This paper size applies to Chinese National Standard (CNS) A4 specifications (210X 297 mm) 1228593 A7 V. Invention Description (145) AGGGCAAGAC CAGGAGGGGGGGGGGGGGAAA CCGCATGGCG AGATGCAGAG 600 ATGGAGAGAC ACACAGGGAG ACAGTGACAA CTAGAGAGAG AAACTGAGAG AAACAGAGAA 660 ATAAACACAG GAATAAAGAG AAGCAAAGGA AGAGAGAAAC AGAAACAGAC ATGGGGAGGC 720 AGAAACACAG ACACATAGAA A TGCAGXTGA CCTTCCAACA GCATGGGGCC TOAGGGCGGT 780 GACCTCCACG CAATAGAAAA TCCTCTTATA ACTTTTGACT CCCCAAAAAO CTGACTAGAA 840 ATAGCCTACT GTTGACGGGG AGCCTTAGCA AT2y \ CATAAA TAGTCGATTT ATGCATACGT 900 TTTATGCATT CATGATATAC CTTTGTTGGA ATTTTTTGAT ATTTCTAAOC TACACAGTTC 960 GTCTGTGAAT TTTTTTAAAT TQTTGCAACT CTCCTAAAAT TTTTCTGATG TGTTTATTGA 1020 AAAAATCCAA GTATAAGTGG ACTTGTGCAT TCAAACCAGO GTTGTTCAAG GGTCAACTGT 1080 GTACCCAGAG GGAAACAGTG ACACAGATTC ATAGAGGTGA AACACGAAGA GAAACAGGAA 1140 AAATCAAGAC tctacaaaga ggctgggcag ggtggctcat gcctgtaatc CCAGCACTTT 1200 GGQAGGCGAG GCAGGCAGAT CACTTGAGGT AAGGAGTTCA AGACCAGCCT GGCCAAAATG 1260 GTGAAATCCT GTCTGTACTA AAAATACAAA AGTTAGCTGG ATATGGTGGC AGGCGCCTGT 1320 AATCCCAGCT ACTTGGGAGG CTGAGGCAGG AGAATTGCTT GAATATGGGA GGCAGAGGTT 1380 GAAGTGAGTT GAGATCACAC CACTATACTC CAGCTGGGGC AACAGAGTAA GACTCTGTCT 1440 CAAAAAAAAA AAAAAAAAA 1459 (2) SEQ ID information at No. 175: ⑴ sEQUENCE cHARACTERISTICS : (A) Length: 1167 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (i i) Molecular type: cDNA (vi) Source: (A) Biology: Human (xi) Sequence description: Sequence identification No. 175: * Printed by GCGCAGCCCT GGCAGGCGGC ACTGGTCATG GAAAACGAAT TGTTCTGCTC GGGCGTCCTC3 60 GTGCATCCQC AGTGQGTQCT GTCAGCCGCA GAGTGTCC AGAACTCCTA CACCATCGGG 120 CTGQC3CCTOC ACAGTCTTOA GGCCGACCAA OAGCCAGOGA GCCAGATGGT GGAGGCCAGC 0.80 CTCTCCGTAC GGCACCCAGA OTACAACAGA CTCTTGCTCG CTiJVCGACCT CATGCTCATG 240 aaottggacg aatccctgtc cgaotctgac accatccgga gcatcagcat tgcttcocag 300 TGCCCTAGCG CGGGGAACTC TTGCCTCGTN TCTGGCTGGG GTCTGCTOGC GAACGGCAGA 360 ATGCCTACCG TGCTGCACTG CGTGAACGTO TCGGTGGTQT CTGAGGANGT CTGCAGTAAQ 420 CTCTATGACC COCTGTACCA CCCCAGCATG TTCTGCGCCG GCGQAC5GGCA AGACCAGAAG 4Θ0 OACTCCTGCA ACGGTGACTC TGCGGGGCCC CTGATCTGCA ACGGQTACTT GCAGGGCCTT 540 GTGTCTTTCG gaaaagcccc gtgtggccaa cttggcgtgc caggtgtcta caccaacctc ¢ 00 TGGAAATTCA CTGAGTGGAT AOAQAAAACC GTCCAGNCCA GTTAACTCTO GGQACTGGGA 660 ACCCATGAAA TTGACCCCCA AATACATTCCCTCTCGA GTC TTC CCTCAGGCCC AGGAGTCCAG QCCCCCAGCC CGTCCTCCCT CAAACCAAGG 780 -148-Zhang scale is applicable to China National Standard (CNS) A4 specifications (210X297 public 1228593 A7) V. Description of the invention (146) GTACAGATCG CCAGCCCCTGCCCCAGAGCCCCCCGCCCCCCTCTCTCC CCCCAAGCCC TCNTCCNTCA GAGTCAGACG 960 TCCAAGCCCC CAAGCCCTCG TTCCGCAGAG CCAGAGGTNC AGGTCCCAGC CCCTCCTCCC 1020 TCAGACCCAG CGGTCCAATG CCACCTAGAN TNTCCCTOTA GACAGTGCCC CCTTGTGGCA SEQ ID 1080 NQTTGACCCA AOCTTACCAG TTGGTTTTTC ATTTTTTGTC CCTTTCGCCT AOATCCAGAA 1140 ATAAAGTNTA AGAGAAGCGC AAAAAAA 1167 (2) information at No. 176: (i) sEQUENCE cHARACTERISTICS: (A) length: 205 amino acids (B) type: amino acid (C) strand type: single strand (D) topology: straight line (ii) molecular type: protein (vi) source: (A) organism: human (xi) sequence Description: Sequence identification number 176 ...

Met Glu Asn Glu Leu Phe Cys Ser Gly Val Leu Val His Pro Gin Trp 1 5 10 15

Val Leu Ser Ala Ala His Cys Phe Gin Asn Ser Tyr Thr lie Gly Leu 20 25 30

Gly Leu His Ser Leu Glu Ala Asp Gin Glu Pro Gly Ser Gin Met Val 35 40 45

Glu Ala Ser Leu Ser Val Arg His Pro Glu Tyr Asn Arg Leu Leu Leu 50 55 60 A1 in Asn Asp Leu Met Leu lie Ivys Leu Asp Glu Ser Val Ser Glu Ser 65 70 75 Θ0

Asp Thr lie Arg Ser lie Ser lie Ala Ser Cys Pro Thr Ala Giy 65 90 95

Aan Ser Cys Leu Val Ser Gly Trp Gly Leu Leu Ala A ^ n Gly Arg Met 100 105 110

Pro Thr Val Leu His Cys Val Aen Val Ser Val Val Ser Glu Xaa Val 115 120 125

Cys Ser Lys Leu Tyr Asp Pro Leu Tyr His Pro Ser Met Phe Cys Ala 130 135 140

Gly Gly Gly Gin Asp Gin Lys Asp Ser Cya Asn Gly Asp Ser Gly Gly 145 150 155 160

Pro Leu 11 «Cys Asn Gly Tyr Lev Gin Gly Leu Val ser Phe Gly Lys 165 170 175 -149-This paper size applies Chinese National Standard (CNS) A4 specifications (21 () &gt; &lt; 297 公 #) (诮 先Read the notes on the back

Revision • Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs 1228593 A7 B7 147 Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs

Ala Pro Cys Gly Glu Leu Gly Val Pro Gly Val Tyr Tlir Asn Leu Cys 180 185 190

Lys Phe Thr Glu Trp lie Glu Ly Thr Val Gin Xaa Ser · 195 200 205 (2) Information on sequence identification number 177: (i) Sequence characteristics: (A) Length: 1119 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology ... Straight line (ii) Molecular type: cDNA (vi) Source: (A) Biology ... Human (xi) sequence description ... Sequence identification number 177: Please read the back Precautions P Binding

GCGCACTCGC GTCCTGGTGC ATCGGGCTGG GCCAGCCTCT CTCATCAAGT TCGCAGTGCC GATGGTGTGA CAACCCTGGC CTCACTGGGT CACCATAGTT ACTAACCATO CAGTTATCCT TGACCTACAG TTCATTTCTC QGTCACAATG CTCAGTACAC ACCACCTCAO GAGGTGAGGO TTAATAAACA

AGCCCTGG0A ATCCGCAGTG GCCTGCACAG CCGTAGGGCA TGGACGAATC CTACCGCGGG TTGCCMCCA AGGGTTGTAC GCTCACTACT CTCCGAAGTC CCGATGTTTA CACTGAATTG AGOTOAGGGA CTGTTOTAGT ATGAATGTAT CAOGGCJAGGT GACTCCTGGA AGAGGGCCCA OAAQ

GGCGGCACTG GGTGCTGTCA tcttgacgcc CCCAGAGTAC CGTGTCCGAG GAACTCTTGC GTCCCAGACT CATTTCGGCA GCTCACTGCA AGACTATCAT GGTGAAATTA AGATTTCCTG TCATATAGCT GAAAGGTGCC3 GATCGTGTTC CTAGCATTTC TTCTCTGCCT TGGTAAAAA

GTCATGGAAA GCCGCACACT GACCAAGAGC AACAGACCCT TCTGACACCA CTCOTTTCTG GTGGGAGQOT ACTTCCAGTG TCACCCGGAA GATTACTGTG GCGTCACTTG CTTCAGTGTC CTTCAAGGAT CCCTCTGGAG CCATTACCCA TTCATTTAGT AGTTGAGGTC GGATCTGTQC number sequence: amine-identifying sequence: 164 base sequence

ACGAATTGTT GTTTCCAGAA CAGGGAGCCA TGCTCGCTAA TCCGGAGCAT GCTGGGGTCT GGGAGTGTGA CAAGGACGTC CACTGTGATC TTGACTGTGC gcctcaagca AGCCATTCCC GCTGGTACTC CCTCCCAGGG AAGCCTTTAA GTATGCTGTC CTGCATCCTG AGTTGTAACA

CTGCTCGCGC CTCCTACACC GATGGTGGAG CGACCTCATG CAGCATTGCT GCTGGCGAAC GAAGCTTTCC CTGCTGCATC: AACTAGGCAG TGTCTATTGT TCTTGGTATC ACATAATTTC CCCTCACAAA TGGGTGTGCA ATCCCT 120 1200 China 1200 120 650 200 1 650 ) A4 gauge (210X297 mm 1228593 A7 B7 V. Description of the invention (148) (B) Type: Amino acid (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecular type: Protein (vi ) Source: (A) Biology: Human (xi) Sequence description: Sequence identification number 178 ...

Met Glu Asn Glu Leu Phe Cye Ser Gly Val Leu Val His Pro Gin Trp 1 5 i〇 15

Val Leu Ser Ala Ala His Cys phe Oln Aan ser Tyr Thr lie Gly Leu 20 25 30

Gly Leu His Ser Leu Glu Ala Asp Gin Glu Pro Gly Ser Gin Met Val 35 40 45

Qlu Ala Ser Leu Ser Val Arg Hie Pro Glu Tyr Asn Arg Pro Leu Leu SO 55 60

Ala Asn Asp Leu Met Leu lie Lys Leu Asp Glu Ser Val ser Glu ser 65 70 7S 80

Asp Thr lie Arg Ser lie Sex 'lie Ala Ser Gin cys Pro Thr Ala Gly * Θ5 90 95

Asn Ser Cvs Leu Val Ser Gly Trp Gly Leu Leu Ala Asn Asp Ala Val 100 105 110 lie Ala lie Gin Ser Xaa Thr Val Gly Gly Trp Glu Cys Glu Lys Leu 1X5 120 125

Ser Gin Pro Trp Gin Gly Cys Thr lie Ser Ala Thr Ser Ser Ala Arg 130 135 140

Thr Ser Cys Cys lie Leu Thr Gly Cys Ser Leu Leu Leu Thr Ala Ser 145 150 15S 160

Pro Oly Thr Leu (2) Information on sequence identification number 179; ⑴Sequence characteristics: (A) Length: 250 base pairs (B) Type: Nucleic acid (C) Share type: Single share 151 This paper size applies to Chinese national standards (CNS) A4 specification (21GX 297 mm) Please read the note on the back page for binding. The printed version of the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs (C) share type 1228593 A7 _ B7 V. Description of the invention (149) (D) Topology: straight line (xi) Sequence description: Sequence identification number 179:

CTGGAOTGGG TTGGTGTTTC AAGCCCCTGC AGGAAGCAGA ATGCACCTTC TGAGGCACCT CCAGCTGCCC CCGGCCGGGG GATGCGAGGC TCGGAGCACC CTTGCCCGGC TGTGATTGCT GCCAGGCACT GTTCATCTCA GCTTTTCTGT CCCTTTGGTG CCGGCAAGCG CTTCTGCTGA AAGTTCATAT CTGGAGCCTG ATQTCTTAAG GAATAAAGGT CCCATGCTCC ACCCGAAAAA aaaaaaaaaa (2) serial number of identification information 180: ⑴ SEQUENCE CHARACTERISTICS: (A) Length: 202 base pairs nucleic acid Single strand (D) topology: straight (xi) sequence description: sequence identification 180 60 120 1B0 240 250 First read the notice on the back P Binding on this page

ACTAQTCCAO TGTGGTGGAA TTCCATTGTG TTGGGCCCAA CACAATGGCT ACCTTTAACA TCACCCAGAC CCCGCCCCTG CCCGTGCCCC ACGCTGCTOC TAACGACAGT ATQATXK: TTA CTCTGCTACT · CGGAAACTAT (Number of Sequences) TTTTATQTAA TTAATGTATG CTTTCTaaa aaa: 180 202 Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs (B) Type (C) Single-stranded nucleic acid (D) Topology: Straight line (xi) Sequence description: Sequence identification number 181 ··

TCCYTTTGKT AATGTTTAGG TTATTCCTCT GGTAGTGTOA AAATTATGCA CTACTCTGTT ATTGATAATA

3TGTCACA GACTTGYNGG ΓΑΤΤΑΟΤΤ TCCTNATtCT 3GTGGATA AATACAAAAA

NAGGTTTKKG AGACAMCCCK AGACCTWAAN CTOTGTCACA GAC1 CAQTGCTAGT AATTTCYTCG TAATGATTCT βΤΤΑΊ TTCTTCTGAA GATTAATGAA GTTGAAAATT GAGG TAGTATAAGT ATCTAAGTCC AOATGAAAGT GTGTTATATA TATCCATTCA AGTTAGTAAT TACTCAGGGT TAACTAAATT ACTTTAATAT GCTGTTGAAC CCTTCGCTAG AA2 \ AAATTAT AAACAGOACT TTGTTAGTTT GGGAAGCCAA TTCTATGTTC TAAAAGTTGG GCTATACATA AATTATTAAd T ^ AATATGGAW 60 120 180 240 300 360 420 -152- present scale paper Applicable to Chinese National Standard (CNS) A4 (210X 297 mm) 1371228593 V. Description of Invention (150

TTTTATTCCC AGGAATATGC KGTTCATTTT ATOAATATTA CSCRGGATAG AWGTWTGAGT AAAAYCAGTT TTGGTWAATA YGTWAATATO TCMTAAATAA ACAAKGCTTT GACTTATTTC CAAAAAAAAA 4Θ0 540 5S8 (2) Sequence identification number 182: (i) sequence pair (A) feature length · J base : Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (xi) Sequence description: Sequence identification No. 182: Read the first 5 notes P

ACAGGGWTTK GRGGATGCTA AGAGGGGAAA ATGGGGCCTA CSTCACACAG AStCCCGAGT TTWGCAATTC ACC ^ TTGCCAC CTAAGGTTAA ACTTTCCCAC TACTMTTCTA AGTCCTCTTC irrCTCTTGGC TTTCTCAATA A.WTGSTOARA AAATTAAAAT

AGSCCCCRGA GAAGTTACAG AGCTGOGACT CTCCAACTTA CCAGAAAAGG CA.GCCTCAOT AARTCTCTAT GTTCTGGTTY

RWTYGTTTGA MSCATYTAGY ACAGGCACAC AACATTCTTC CAACTTAGAT KKGAGTCCTM YCATCTCATG MACTfTAAAA

TCCAACCCTG TGGTGCGMTG AGTCACTGAA ATATGTGATG AAAATCTTAG CYTGGGGGTT TTTAATTTGG

GCTTWTTTTC GCACCCCTGQ GCAGGCCCTG TCCTTAGTCA AGTACTTTCA GATAGG TACC

rAGGAANT HGCATARA 60 120 1B0240 300 360 420 479 Order printed by the Consumers' Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs (2) Information on sequence identification number 183: ⑴ Sequence characteristics: (A) Length: 384 base pairs (B) Type: Nucleic acid ( C) Stock type ···················································· ·······················································

AGGCGGGAGC AGTACCAGTA GGTGCCAGCC GCCAGCACCA TGTTAATCCT CAGCACTCTA GGCATTTCAA

AOAAGCTAAA CCAATAA.CAQ TQACCQCCAC GTGGCAGCTC GCCAOTCTTT GGCAGCCACT

: CAAAGCCC 3CCAGTGCC

GCi TGC (TCTCACATTT TGQTGCCTGT CTCTTCAAGC ATCAATCAAT

AAGAAQAGTG GCAOTGCCAG AGiTGCCAGCA CCAGTGGTGG GGGCTCTTCG CTGGCCTTGG GGTTTCTCCT ACAAGTOAGA CA.GGGTGCAT CCTCAGAAAC TGAAGOTGAC ACTCTGCATT

CACTGGTGCO CTXCAGTGCT TGGAGCTGQT TTTTAGATAT CTACTCAACA ARATCTATTT ¢ 0 120 1B0 240 300 3603Θ4 153 This paper size applies Chinese National Standards (CNS) A4 regulations (210X297 mm 1228593 A7 B7) V. Description of the invention (151) (2) Serial identification number 184 Information: (i) Sequence characteristics: (A) Length: 496 test pairs (B) Type: Nucleic acid (C) Strand type ·· Single strand (D) Topology: Straight line (xi) Sequence description: Sequence identification number 184 * ACCGAATTGG aACCGCTGGC TTATAAGCGA TCATGTYYNT CCRGTATKAC CTCAACGAGC 60 AGGGAGATCG AGTCTATACG CTGAAQAAAT TTGACCCGAT GGGACAACAG ACCTGCTCAG 12 0 CCCATCCTGC TCGGTTCTGG CCAGATGACA AATAGTCTSG ACACCGAATC ACCATCAAGA 180 AACGCTTCAA GGTGCTCATG ACCCAGCAAC CGCGCCCTGT CCTCTGAGGG TCCCTTAAAC 240 TGATGTCTTT TCTOCCACCT GTTACCCCTC GGAGACTCCG TAACCAAACT CTTCGGACTG 300 TGAGCCCTGA TGCCTTTTTG CCAGCCATAC TCTTTGGCAT CCAGTCTCTC GTGGCGATTO 3 € 〇ATTATGCTTG TGTGAGGCAA TCATGOTGGC ATCACCCATA AAGGGAACAC ATTTGkCTTT 420 TTTTTCTCAT ATTTTAAATT ACTAGMAGAW TATTWMAGAW WAAATGAWTT GAAAAACTST 480 TAAAAAAAAA AAAAAA 496 (2) Sequence recognition 1S5 No. information: (i) Sequence characteristics: (A) Length: 384 base pairs (B) Type: Nucleic acid (C) Share type: Single strand (D) Topology: Straight line. Employees' cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs printing (xi) sequence Description: SEQ ID NO 185: GCTGGTAGCC TATGGCGKGO CCCACGGAGG GGCTCCTGAG GCCACGGRAC AGTGkCTTCC 60 CAAGTATCYT GCGCSGCGTC TTCTACCGTC CCTACCTGCA OATCTTCGGQ CAGATTCCCC 120 AGGAGGACAT GGACOTGGCC CTCATGGAGC ACAGCAACTG YTCGTCOGAG OCCGGCTTCT 18 〇GGGCACACCC TCCTGGGGCC CAGGCGGGCA CCTGCGTCTC CCAGTATGCC AACTGGCTGG 240 TGGTGCTGCT CCTCGTCATO TTCCTGCTCG TGOCCAACAT CCTGCTGGTC AACTTGCTCA 300 TTGCCATGTT CAGTTACACA TTCGGCAAAG TACAGGGCAA CAGCGATCTC TACTGGGAAG 3 ^ 0 GCGCAGCOTT ACCGCCTCAT CCGQ 3Θ4 (2) Information on sequence identification number 186: ⑴Sequence characteristics: -154 · This paper size applies Chinese National Standard (CNS) A4 Regulation (210X 297 mm) 1228593 A7 B7 V. Description of the invention (152) (A) Length: 577 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (xi) Sequence description: Sequence identification number 186: OAGTTAGCTC CTC CACAACC TTGATGAGGT CGTCTGCAGT GGCCTCTCGC TTCATACCGC 60 TNCCATCGTC ATACTGTAGG TTTOCCACCA GYTCCTGGCA TCTTGOGGCG GCNTAATATT 1 ^ 0 CCAGGAAACT CTCAATCAAG TCACCGTCGA TGAAACCTOT GGGCTGGTTC TGTCTTCCGG 180 TCQGTGTGAA AGGATCTGCC AGAAGGAGTG CTCGATCTTC CCGACACTTT tGATGACTTT 240 ATTGAGTCGA TTCTGCATGT CCAGCAGGAQ GrTGTACGAG CTCTCTGACA GTGACGTCAG 3 00 CAGCCCTATC ATGCCGTTGA MCGTGCCGAA GARCACOGAG CCTTGTOTGG GGGKKGAAGT 360 CTCACCCAGA TTCTGCATTA CCAGAGAGCC GTGGCAAAAG ACATTGACAA ACTCGCCCAG 42 〇GTGC3AAAAAG AMCAMCTCGT GOARGTGCTO GCCGCTCCTC GTCMGTTGGT GGCAGCGCTW 4Θ0 TCCTTTTGAC ACACAAACAA GTTAAAGGCA TTTTCAGCCC CCAGAAANTT GTCATCATCC 540 AAGA.TNTCGC ACAGCACTNA TCCAGTTGGG ATTAAAA sequence number: 577 sequence number: 5772 (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (xi) Sequence description: Sequence identification number 187: AACATCTTCC TGTATAATGC TGTGTAATAT CGATCCGATN TTGTCTGSTG AGAATYCATW 60 ACTKGGAAAA GMAACATTAA AGCCTGGACA CTGGTATTAA AATTCACAAT ATGCACAAT AGTG TGTCAATCTG CTCCCYYNAC XTTGTCATCA CCAGTCTGGG AAKAAGGGTA 180 TGCCCTATTC ACACGTGTTA AAAGGGCGCT AAGCATTTXT GATTCAACAT CTTTTTTTTT 240 GACACAAGTC CGAA2VAAAGC AAAAGTAAAC AGTTATYAAT TTGTTAGCCA ATTCACTTTC 300 TTCATGGGAC AOA, GCCATYT GATTTAAAAA GCAAATTGCA TAATATTGAG GTTYGGGAGC 260, Ministry of Economic Affairs Bureau of Standards employees consumer cooperatives printed TGATATTTGA GCGGAAGAGT AGCCTTTCTA CTTCACCAGA CACAACTCCC TTTCATATTG 420 GGATGTTNAC NAAAGTWATG TCTCTWACAG ATGGGATGGT TTTOTGGCAA TTCTGTTCTG 4B0 AGGATCTCCC AOTTTATTTA CCACTTGCAC AAOAAGGCGT TTTCTTCCTC AGGG 534 (2) Information on sequence identification number 188: (i) Sequence characteristics: (A) Length: 701 base pairs (B) Type ·· Nucleic acid-155- This paper The scale is applicable to the Chinese National Standard (CNS) A4 gauge (210X 297 mm) 1228593 A7 B7 V. Description of the invention (153) (C) Stock type: single stock (D) Topology: straight line (xi) 188: AGAAACCAGT ATCTCTNAAA ACAACCTCTC ATACCTTGTG TGTGTGtGCG CGCATATTAT ATAGACAGGC ACATCTTTTT CCTGTTTGGT ATCTATATCT GTGAAAGTTT TAATGATCTC ttgtcttctg tgtaaatggt act agagaaa acacctatnt tttattcgac ATGAAGGAAA xttccagatn acaacactna ggggacaaag aaaagcaaaa ctgamcataa raaacaatwa ACAOAAATWR GGTAGTATAT TGAARNACAG CATCATTAAA GCAAAAAACA TGTACNGACT TCCCGTTGAG TAATGCCAAG CTTGCCGTTC ATTACATGTT TNAAAOTGGT GTGGTGGGCC ctgactgata aagctgtaca AATAAGCACt gtgcctaaca ATGCTTAATT CACAAATGCT AATTTCATTA TAAATGTTTG TTTTTCTGTN TTCCCAGAGC TGAQATNTTA GATTTTATGT gaaaataata acattgaaga aaaananaaa aaanaaaaaa (2) SEQ ID Information Number of 1S9: (i ) Sequence characteristics: (A) Length: 482 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (xi) Sequence description: Sequence identification number 189:

GACCTAATTT TGTGTGCGTQ TACTTTTGTA AAAGCTTATG CCATAATGTC TTQQGGACCT TATGAGTCAA TCTAGTTNOT CAAACTCTCC CTKGACKARG CCTGGTGAGA ARTTGCATAA RMGTTWTKTT WTTCTCCCTT TTGTTtTTTT TATNATAAAA AAAATATTGA AATGATGGAA AGCAACACAG TAATGTTGAC CTAAAATACA ctttgaacta AGTAXNAAGT GAAAAANTAC A 60 120 180 240 300 360 420 480 540 600 6GQ 720 761 Read back νέ binding economic precautions page P Printed by the Consumer Standards Cooperative of the Ministry of Standards

TTTTTTTTTT CACGGGGOCT AAGCCGCGTG AAGGCAGGGG TGATAGGCAC GTCATTGTGC AAATTTGGCT GTTCGGCCCA CC

TTTGCCGATN ATNAGAAGCA CTGCCTTCTC CCACCAOTCC AGGCCACCCG CCTG &lt; NGT (GCTCCNCGTC

rGCCCAGG rCATNGAA

CTACTATTTT AQAAGGAAGG TOTCTGTCTC AGGGGTGGGA GTACAGACCC CACAGCGTAN NGGGCAimT CAAAAANTAT

ATTGCAGGAN AGGGAGGGCA CTGGTGCAGG ATACAGGGGG CTCGGCTCCT ATCTGGAAAA TCCAANTTNO TCACCCNNCT

GTGQGGOTGT CAGCCCCTTO CA.CATGGGGA TGGGANGTGT gacaggtnga GACAGAATGC GCTNGGTCTT CCNAATTGCT

ATGCACCGCA CTGAGCAACA GACCTTCCCC GCATAAC5AAG TTTCGACCAG TTTCCTTTTC GGTACNCTTG TGCNQGNGCC eo 12 0 180 240 300 3 € 0 420 480 482 (2) Information on sequence identification number 190: (i) Sequence characteristics: (A) Length: 471 base pairs (B) Type ·· Nucleic acid • 156- This paper size applies Chinese National Standard (CNS) A4 specification (210X 297 mm) 1228593 A7 B7 V. Description of the invention (154) (C) Stock type: single strand (D) Topology: straight ( xi) Sequence description: Sequence identification number 190

τττττττττττ aaaactctcg aatgtctggt CGGTTtTGAC TAA.GTACTCA ΤαΑΑΑΑΑΤΤΤ CTACATCNAC TCTGTAATTN

TTXTAAAACA CATCCAGTQA CAAATGATAC ATACAATGCA TCACATACAT CATGTATGCA CTTGATCATT ANTTCAACCT

GTTTTTCACA gaactaccat AATGGAACCA CAAAAAJVAAA TAAGACACAG ATCCAACCAA GCCAGGAACN CCGTACNGAA ACAAAATTTA ACACCACAtT TTCAATCTTA AGGGGGGGGG TTCTAGTCCA agaacttnat AAAAGTTNAA ΑΛΑΝΝΤΤΝΤ

TTAGAAGAAT ACAGCTNGGA CACATQCACG GACCACATGG GTCKTAAAATC TGGTGATCAT ANCACNCNGT TATACACTCC

AGTGGTTTTC ATQTNCTCCA AAAGAACAAG ΑΤΤΑΛΑΑΤΤΤ AGAACTGCNT GANTNCXCXA ACAAAAANAA C 60 12 0 180 240 300 360 420 471 Please read the information on the back of (2) sequence identification number 191: ⑴Sequence Features · (A) Length: 402 base pairs (B) Type : Nucleic acid (C) Falcon: Single strand (D) Topology: Straight line (xi) Sequence description: Sequence identification item 191 P i

GAGGGATTGA

GTCTTCCACT

ATTCTTCACC

CTTCCXTTGT

CTCGTTCTCT ctttgtgcat

AAGAGTGATC

AGGTCTGTTC

CACTGTCTGT

AGTOACATCT

TAAGACTTCA

AACA ^ TGTCC

CCATTTTAAA

TGTCTGCAAA

TASTOTCQGM

AAGCTTTTTA

TCTAGGACCT

TCTGGTAAAG

TCTGCTTGAA

TATACTTAAT

AGTTGCOXTA

CTGTTCAGCC

ACCCAGACWG

TTTTGGATTC

TCTTAAGTTT

GTATTTGGCT

AGGGCATTGK

GTATATCTGC

ACCAACTCTA

TATCTTCATA

AGTTAGTATA

TGTAGAAAGG

GAACAACCCA

TNCACTAGGT

CA

ACAAGTTGCT

AATAGAACAA

AGCTCTTCCA

AATTYAATTG

CCTAAAGTCC

TAAATTGTGC 60 120 1Θ0 240 300 360 402, printed by k-nucleic acid single strand in the consumer cooperation of the Central Bureau of Standards of the Ministry of Economic Affairs (2) Information on sequence identification number 192: (i) Sequence characteristics: (A) Length: 601 base pairs Type (C) Stock type (D) Topology: Straight-157 This paper size is applicable to Chinese National Standard (CNS) A4 gauge (210X 297 mm) 1228593 kl B7 V. Description of the invention (155) (xi) Sequence description: SEQ ID NO 192: _ gAgctcggat ccaataatct ttgtctgagg gcagcacaca tatncagtgc catggnaact 60 GGTCTACCCG ACATXSGGAGG AGCATGCCGT AGNTATATAA GGTCATTCCC TGAGTCAGAC 12 0 ATGCYTYTTT GAYTACCGTG TGCCAAGTGC TGGTOATTCT YZ ^ ACACACYT CCATCCCGYT 180 CTTTTGTGGA AAAACTGGCA CTTKTCTGGA ACTAGCARGA CATCACTTAC AAATTCACCC 240 acgagacact tgaaaggtot aacaaagcga ytcttgcatt GCTTTTTOTG CCTCCGGCAC 300 CAGTTGTCAA TACTAACCCG CTGGTTTGCC TGCATCACAT TTGTGATCTG TAGCTCTGGA 360 TACATCTCCT GACAGTACTG AAGAACTTCT TCTTTTGTTT CAAAAGCARG TC1TGGTGCC 42 0 TGTTGGATCA GGTTCCCATT TCCGAGTCYG AATGTTCACA TGGCATATTT WACTTCCCAC 480 AAAACATTGC GATTTGAGGG TCAGCAACAG CAAATCCT GT TCCGGCATTG GCTGCAAGAG S40 CCTCGATGTA GCCGGCCAGC GGCAAGGCAG GCGCCGTGAG CCCCAGCAGC AGCAGAAGCA 600 G 601 (2) Information on sequence identification number 193: ⑴ Sequence characteristics: (A) Length · 608 base pairs (B) Type: Nucleic acid (C) Share type: single strand (D) in topology: sequence Description linear (XI): SEQ ID NO 193: ATACAGGCCA NATCGCACCA CGAAGATGCG CTTGTTGACT GAOAACCTGA TGCGQTCACT 60 GGTCCCGCTO TAGCCCCAGC OACTGTCCAC CTGCTGGAAQ CGGTTGATGC TGCACTCYTT 120 CCCAACGCAG GCAGMAGCGG GSCCGGTCAA TGAACTCCZAY TCGTGGCrTG GGGTKGACGG 1Θ0 TKAAGTGCAG GAAOAGGCTG ACCACCTCGC GGTCCACCAG GATGCCCGAG TGTGCGGGAC 240 CTGOAGCGAA ACTCCTCGAT GGTCATGAGC GGGAAGCGAA TGAGGCCCAG GGCCTTGCCC 300 AGAA.CCTTCC GGCTQTTCTC TGGCGTCACC TGCAGCTGCT GCCGCTGACA CTCGGCCTCQ 360 GACCAGCGGA CAAA.CGGCRT TGAACAGCCG CACCTCACGG AtGCCCAGTG TGTCGCGCTC 420 CAGGAMMGSG ACCAGCGTGT CCAGGTCAAT GTCGOTGAAG CCCTCOGCGG GTRATGGCGT &lt; 480 CTGCAGTGTT TTTGTCGATG TTCTCCAGGC ACAGGGTGGC CAGCTGCGGT TCATCGAAGA 540 GTCGCGCCTG CGTGAGCAGG ATGAAGOCGT TGTCGGCTCG CAGTTCTTCT TCAGGAACTC 600 CACGCAAT $ 〇a (2) Information on sequence identification number 194:, printed by the Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs, sequence characteristics: (A) Length: 392 base pairs (B) Type: Nucleic acid (C) shares Type: Single strand (D) Topology: Straight line (xi) Sequence description: Sequence identification number 194: -158-------- --- ----- This paper size applies to Chinese National Standard (CNS) A4 regulation station (210X 297 mm) 1228593 A7 _ B7 V. invention is described in (156) GAACGGCTGG ACCTTGCCTC GCATTGTGCT TGCTGGCAGG GAATACCTTG GCAAGCAGYT 60 CCAGTCCGAG CAGCCCCAGA CCGCTGCCGC CCGAAGCTAA GGCTGCCTCT GGCCTTCCCG 120 TCCGCCTCAA TGCAGAACCA GTAGTGGGAG CACTGTGTTT AGAGTTAAGA GTGAACACTG 1Θ0 TTTGATTTTA CTTGGGAATT TCCTCTGTTA TATAGCTTTT CCCAATGCTA ATTTCCAAAC 24 0 AACAACAACA AW \ TAACATG TTTGCCTGTT AA.GTTGTATA AAAGTAGGTG ATTCTGTATT 300 TAAAGAAAAT ATTACTGTTA CATATACTGG TTGCAATTTC TGTATTTATT GKTNGTSTGG 360 AAATAAATAT AGTTATTAAA GGTTGTCANT CC 392 (2) Sequence identification number 195: (A) sequence length (B) ) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Sequence Description linear (xi): SEQ ID NO 195:. CCSTTKGAGG GGTKAGGKYC CAGTTYCCGA GTGGAAGAAA CAGGCCAGGA GAAGTGCGTG 60 CCGAGCTGAG GCAGATGTTC CCACAGTGAC CCCCAGAGCC STGGGSTATA GTYTCTGACC 12 〇CCTCNCAAGa aaaqaccacs ttctggggac atgcgctgga GGGCAGGACC TAGAGOCACC 180 AAGGGAAGGC CCCATTCCGG GGSTGTTCCC CGAGGAGGAA GGGAAGGGGC TCTGTGTGCG 240 CCCCASGAGG AAGAGGCCCT GAGTCCTGGG ATCAGACACC CCTTCACGTG TATCCCCACA 3〇 〇CAAATGCAAG CTCACCAAGG TCCCGTCTCA GTCCCCTTCC STACACCCTG AMCGGCCACT 360 GSCSCAGAGG CACCCAGAGC ACGCCACCCG CCATGGGGAR TGTGCTCAAG GARTCGCNGG 420 GCARCGTGGA CATCTNGTCC CAGAAGGGGG CAGAATGTCC AATAQANAGA AAA ATCAQANAGA CTANAA

Printed by 1T Consumer Cooperatives, Central Standards Bureau, Ministry of Economic Affairs

(2) Information on sequence identification number 196: (i) Sequence characteristics: (A) Length: 665 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (xi) sequence Description: SEQ ID NO 196: GGTTACTTGG TTTCATTGCC ACCACTTAGT GGATGTCATT TAGAACCATT TTGTCTGCTC CCTCTCGAAG CCTTGCGCAG AGCGGACTTT GTAATTGTTG GAGAATAACT GCTGAATTTT WAGCTGTTTK GAGTTGATTS GCACCACTGG ACCCACAACT TCAATATGAA AACYAV7TTGA ACTWATTTAT TATCTTGTGA AAAGTATAAC AATGAAAATT TTGTTCATAG TGTATTKATC AAGTATGATG AA7y \ GCAAWA GATATATATT CTTTTATTAT GTTAAATTAT GATTGCCATT ooooo 6 2 Θ 4 o 112 3 -159 -This paper size applies Chinese National Standard (CNS) A4 gauge (210X297 mm) 1228593 A7 V. Description of invention (157

ATTAATCGGG TCACTTGGTT WATATTTATT TCTTGACAGA TTGTTAGAAT TTTGCAATCA AAGTG

aaaktgtgga ATTTTATTGT TCATTA? \ TTT AATCGATCTT OTATAAAQGT GGCTGAAATG

GTGTATOTTC AAA.TQARTTA CTTTCCTKGT GATGCTGTGQ TGTAGCCCAT TGGCATCOTN TTTTCA CAAAAl

'ACAGT • TTCTt WAGGTWAAT AAGTAGTTTG CNAACTTCAA TTCTAATTCC

AATATATGCC TTTTGTAA.CT AATTTAAGAR AATGGTATGT TTTGAAAAGA WTGCATGATT ACCCACATCC CTATGAGTTT AGAAAAAAAT GACCACATAC AACTTTATAA ACTAGCAAAN 3S〇420 480 540 ¢ 00 665 (2) Information on Sequence Identification No. 197: ⑴Sequence Features: (A) Length · B · Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (xi) Sequence description: Sequence identification No. 197 Please read on the back 5 I Matter P This page is attached

TXTTNTTTTT TTTTTTTTGC AGGAAGGATT CCATTTATTQ TGOATGCATT TTCACAATAT ATGTTTATTG GAGCGATGCA TTATCAGXGA JU ^ GTATCAA OTOTTTATAA NATTTTTAGG AAGGCAGATT CACAQAACAT GGTNGTCNGC TTGCAGTTTT ACCTCGTAKTA OATOACAGAG AATTATAGTC NAACCAGTAA ACNAGGAATT TACTTTTCAA AAGATTAAAT CCAAACTGAA caaaattcta ccctgaaact tactccatcc aaatattqga ataanagtca gcagtgatac ATTCTCTTCT GAACTTTAGA TTTTCTAGAA AAATATGTAA TAGTGATCAG tgttcaaaag TACAACNAAG caatgttccc ttaccatago ccttaattca CATTTCACTC CCATCACGGG AGTCAATGCT ACCTGGGACA CTTGTATTTT GTTCATNCTG ANCNTGGCTT AA

GAAGAGCTCT AACTTTGATC 60 120 180 240 300 360 420 480 432 Order, printed by the Consumer Cooperatives of the Central Government Bureau of the Ministry of Economic Affairs (2) Information on sequence identification number 198: (i) Sequence characteristics: (A) Length: 478 base pairs ( B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line

(xi) Sequence description: Sequence identification TTTNTtTTON ATTTCANTCT GTANNAANTA TGTNTCCACN ACAAATCATN TTACliTNAGT TGAGTATATT TTGAAAAGGA CAAGTTTAAA TATACATGGC TTGATTGATA TTTAGCACAG NATATATOTC AATCNGATTT AAGATACAAA

No. 198: TTTTCATTAT AAGAGGCCAN GTANACNCAT CANAAACTGA ACAGATCCTA

GTTTATTANA CTACATTGTA ATTGCCGANC GTGAGTTACC TGGTACATAN

AAAATATNAA CAACATACAC ATANCACATT AGAAANAAAT CATCNTGTAO 60 120 180 240 .300 160- This paper size applies to Chinese National Standard (CNS) A4 gauge (210X 297 mm) 1228593 A7 B7 V. Description of the invention (158) GAGTTGTGGC TTTATGTTTA CTGAAAGTCA ATGCAGTTCC TGTACAAA TACCTCTACT CCATGGTTAA GAATCGTACA CTTATGTTTA CATATGTNCA 420

GGGTAAGAAT TGTGTTAAGT NAANTTATGG AGAOOTCCAN GAGAAAAATT TGATNCAA 47S (2) Information on sequence identification number 199 ... Sequence characteristics: (A) Length: 482 base pairs (B) Type · Nucleic acid (C) Share type: Single strand (D) in topology: sequence Description linear (XI): SEQ ID NO 199: agtgacttgt cctccaacaa AACCCCTTGA tcaagtttgt GGCACTGACA ATCAGACCTA 60 TGCTAGTTCC TGTCATCTAT tcgctagtaa atgcagactg gaggogacca AAAAGGGGCA 120 TCAAGTCCAC3 CTGGATTATT TTQGAGCCTG CAAATCTATT CCTACTTOTA CGGACTTTGA 1B0 AGTGATTCAG TTTCCTCTAC GGATGAGAGA CTGGCTCAAG AATATCCTCA TGCAGCTTTA 240 TGAAQCCNAG TCTC3AACACG CTGGTTATCT NAGATGAGAA NCAGAGAAAT AAAGTCNAC3A 300 AAATTTACCT GGANGAAAAG AGGCTTTN ^ G CTGGGGACCA TCCCATTGAA CCTTCTCTTA 360 ANGGACTTTA AGAANAAACT ACCACATGTN TGTNGTATCC TGGTGCCNGO CCGTTTANfTG 420 aacntngacn itcacccttnt ggaatanant cttgacngcn TCCTGACT sequence: TCCTGACT Right (B) Type: Nucleic Acid (C) Stock Type ·· Single Stock. Printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs (D) in topology · linear (xi) Sequence Description: SEQ ID NO 200: CGOCCGCAAG TGCAA.CTCCA GCTGGGGCCC3 TGCGGACGAA GATTCTGCCA GCAGTTGGTG 60 CQACTOCQAC GACGGCGGCG GCGACAGTCG CAGGTGCAGC GCGGGCGCCT GGGGTCTTGC 120 AAGGCTGAGC TGACGCCGCA GAGGTCGTGT CACGTCCCAC GACCTTGACG CCGTCGGGGA 180 CAGCCGGAAC AGAGCCCGGT GAANGCGGGA GGCCTCGGGG AGCCCCTCGC GAAGGGCCGC 240 CCGAGAtSMA CGCAGGTGCA GGTGCCCGCC 270 -161-This paper size applies to the Chinese National Standard (CNS) A4 gauge (210 X297 mm) 1228593 A7 B7 V. Description of the invention (159) (2) Information of sequence identification number 201: ⑴ Sequence characteristics: ( A) Length: 419 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (xi) Sequence description: Sequence identification number 201

TTTTTTTTTT TTTTGGAATC TACTGCGACC ACAGCAGGTC GCTAGCAAGG TAACAGGGTA GGGCATGGTT ACATGTTCAG TTGATTOOTT TGTCTTTATG GGGGCGOGGT GGGGTAGGOG TGGAGTGGGT GCACCCTCCC TGTAGAACCT GGTTACNAAA TCTGTGACCG TCATTTTCTT GACATCAATG TTATTAGAAG TCCACTGTNT CTGGAGGGAG ATTAGGGTTT CTTGCCAANA AAAAGTTGGA TGATNCANGT ACNGAATi ^ CG GANGGCATAJN

AGCAACfiAGT GTCAACTTCC AAANCGAAOC C30TTGGGGCA TCAGGATATC TCCAANCAAA TTCTCATANT

TTATTTTGCA TTTGTCGIGG ANAANTAACA CTTCACCTGG TTTTAGAGAG ATCCACNTGA CGGTGGCOA 60 120 1B0 240 300 360 419 Please read the back τδ 5 ί Matters P This page is bound and bound. It is printed by (2) serial identification number 202 of the Central Consumer Bureau of the Ministry of Economic Affairs: ⑴Sequence features: (A) Length: 609 base pairs (B) Type: Nucleic acid (C) Strand type ·· Single strand (D) Topology: Straight line (xi) Sequence description: Sequence identification number 202:

TTTNTTTTTT TTTTTTTTTT TTTTTTTTTT TTTTTTTTTT TTTTTTTTTT TTTTTTTTTT TGGCACTTAA tccattttta tttcaaaatg tgtacaaant ttnaatncnc cattatacng GTNATTTTNC aaaatctaaa nnttattcaa atwtnaqcca aantccttac ncaaatnnaa TACNCHCAAA AATCAAAAAT ATACNTNTCT TTCAGCAAAC TTNGTTACAT AAATTAAA? A AATATATACG QCTGGTQTTT TCAAAGTACA ATTATCTTAA CACTQCAAAC ATNTTTNNAA taaaaaaaaa cactnccgca aagottaaag ggaacaacaa attcntttta iTATTATAAAA AtCATATCTC AAATGTTAGG GGAATATATA CTTCACACNG GGATCTTAAC TTTTACTNCA CTTTGTTTAT ΤΓΤΤΤΤΆΝΑΑ CCATTOTNTT GGGCCCAACA CAATGGNAAT NCCNCCNCNC TGGACTAGT

ggaactaaaa CAACANCNNC 120 180 240 300 360 420 48 0 S09 -162- This paper size applies to Chinese National Standard (CNS) Α4 gauge (210 × .297 mm 1228593 A7 B7 V. Description of the invention (160) (2) Sequence identification number 203 Information: (0 sequence characteristics ... (A) length, 583 base pairs (B) type: nucleic acid (C) strand type: single strand (D) topology: straight line (xi) sequence description: sequence identification number 203

TTTTTTTTTT

TACACATATT

TAAATGGAAA

GAAAATCTTC

ATTTTTCTTG

GCTTCTCTAG

AGGOAAAACA

TACGTTAATA

TCCATTTTAG

ATTCAAAAGC

TTTTTTTTGA

TATTTTATAA

CTGCCTTAGA

TCTAOCTCTT

TCTTTAAAAT

CCTCATTTCC

GGAAGAGANA aaatagcatt

TCACTAAACQ

TAATATAAGA

CCCCCCTCTT

TTGGTATTAG

TACATAATTC

TTGACTGTAA

TATCTAATCT

TAGCTCTTAT

ATGGCACACA

TTGTGAAGCC

ATATCNAAAG

TATTTCACAT

ATAAAAAACA atattcaaaa

TTAGGAATTA

ATTTTTGACT

TTCCATTITT ctactattag

AAACAAACAT

AGCTCAAAAG

TGCCAGAATG

ACTCATCTTT

AGTTA.CCATT

GGCAGCTTTT

GCTTAAAATC

CTTOTAAAAC

TCCCTAXTCC

TAAGTGGCTT

TTTATATTCA

AAGGCTTAGA

CAAAAGGTTT

CTG

TTATTTTAGT

AAAATCAAAC

TGCCTAAAGT

ATCCAAATTC

AAOTCAATTT

TTTTCCXAAA

TATTTGTACC

TCCTTTTATG

GTGAACATTT € 0 120 1B0 240 300 350 420 480 540 5Θ3, printed by TTCTTTTTTT TTGANTU ^ TGA GGATCGAGTT 60 CTCATCTTTC CAGCTTTAAA ATAACAATCA 120 AAACTA TGA ATCACTA TGA TCAACATA CTCA 300 TATAGTT CTC 3 ^ 0 GNTTATCCAT TATAATTAGT TNGGCAGGAG 420 TAATAAAACT GAMTACCAG TTAAATATCC 4BO gtataattag ctaattcact TTACAAGCAT S40 CCNTAGCCCA AGACAATGG 589 (2) Information on sequence identification 2Θ4: ⑴ Sequence characteristics: (A) Length: 589 base pairs (C) ) Stock type ·········································································

TTTTTTTTNT TTTTTTTTTT TTTTTTNCTC TTTCACTCTC TAGATAGGGC ATGAAGAAAA AATCTCTTAT GCTATATCAT ATTTTAAGTT TGAAGGAAAT CTGTTCATTC TTCTCATTCA TGAGAGGTTT TTCTTCTCTA TTTACACATA ATTTTCATGC AAACTTAAATCAATCAATC

CTAATACAAA tcacatttac ngacnagcaa AAAATAATTA AAGGAACATT TTTAGCCTGG TTATTNAGAA TGAATTCACA TGTTATTATT -163 · This paper size applies to the Chinese National Standard (CNS) A4 specification (210X 297 mm) 1228593 A7B7 V. Description of the invention (161) (2) Serial number 205 i) Sequence characteristics: (A) Length: 545 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology ·· Straight line (xi) Sequence description: Sequence recognition No. 05: TTTTTNTTTT TTTTTTCAGT AATAATCAGA ACAATATTTA TTTTTATATT TAAAATTCAT ¢ 0 AGAAAAGTGC CtTACATTTA ATAAAAGTTT GTTTCTCAAA GTQATCAGAO GAATTAGATA 12 0 TNOTCTTQAA CACCAATATT AATTTGAGGA A7UVTAGACCA AAATACATTA AGTAAATTAT 180 TTAAGATCAT AGAGCTTGTA AGTGAAAAGA TAAAATTTGA CCTCAGAAAC TCTGAGCATT 240 TLAAAATCCAC TATTAQCAAA TAAATTACTA TGGACTTCTT GGTTTAATTT TGTGATGAAT 300 ATGGGGTGTC ACTGGTAAAC CAACACATTC TQAAGGATAC ATTACTTAGT GATAGATTCT 360 TATGTACTTT GCTANATNAC GTGGATATGA GTTGACAAGT TTCTCTTTCT TCAATCTTTT 420 AAOCOGCNGA NGAAATOAGG AAGA7 \ AAGAA AAGGATTACG CATACTGTTC TTTCTATNGG 480 AAGGATTAGA TATGTTTCCt tt gccaatat taaaaaaata ATAATGTTTA CTACTAGTGA S40

AACCC S4S (2) Sequence identification number 206: (i) Sequence characteristics: (A) Length: 487 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line

(ii) Molecular type: CDNA • Consumption cooperation printed by the staff of the Central Standards Bureau of the Ministry of Economic Affairs (xi) Sequence description: Sequence identification number 206: ττττττττττ ttttttagtc aagtttctna ΤΤΤΤΤΑΤΤΑΤ AATTA2 \ AGTC TTGGTCATATTA AATTAAAGAATTA . CCATTATTGA GTANATATAT TCCTCCAAGA GIX5GATGTGT ^ 00 CCCTTCTCCC ACCAACTAAT GAANCAGCAA CATTAGTTTA ATTTTATTAG TAGATNATAC ^ 40 ACTQCTGCAA ACGCTAATTC TCTTCTCCAT CCCCATGTNG ATATTGTGTA TATGTGTGAG 300 TTGGTNAGAA TGCATCANCA ATCTNACAAT CAACAGCAAG ATGAAGCTAG GCNTGGGCTT 360 TCGGTGAAAA TAGACTGTGT CTGTCTGAAT CAAATGATCT GACCTATCCT CGGTGGCAAG 420 AACTCTTCOA ACCGCTTCCT CAAAGGCNGC TGCCACATTT GTGGCNTCTN TTGCACTTGT 480 TTCAAAA 487 • 164- - ____ This paper size applies Chinese National Standard (CNS) A4 (210X 297 mm) 1228593 A7 B7 V. Description of the invention (162) (2) Information on serial identification number 207: ⑴ Sequence characteristics: (A) Length: 332 Base pair (B) Type: Nucleic acid (C) Strand type: Single strand (1 &gt;) Topology: Straight line

(Ii) MOLECULE TYPE: cDNA (xi) sequence DESCRIPTION SEQ ID NO ·· 207:.. TGAATTGGCT AAAAOACTGC ATTTTTANAA CTAGCAACTC TTATTTCTTT CCTTTAAAAA 6〇TACATAGCAT TAAATCCCAA ATCCTATTTA AAOACCTGAC AGCTTGAGAA GGTCACTACTC 120 GCATTTATAG GACCTTCTGG TGGTTCTGGT GTTACNTTTG AANTCTQACA ATCCTTGANA 1Θ0 ATCTTTGCAT GCAGAGQAGG TAAAAGGTAT TGGATTTTCA CAGAGGAANA ACACAGCGCA 240 GAAA.TGAAGG GGCCAGGCTT ACTGAGCTTG TCCACTGGAG GGCTCATGGG TGGGACATGG 300 AAAAjGAAGGC AGCCTAGCCC GTQGOOAGCC CA 332 (2) Information on sequence identification 208: ⑴ Sequence characteristics: (A) Length: 524 test pairs (B) Type: Nucleic acid (C) Stock type: Single stock

(D) Topology: straight line (ii) Molecular type: cDNA (xi) Sequence description: Sequence identification number 208 ... Printed by AGCGCGTGGT GCGGAGGGCG TTACTQTTTT GTCTCAGTAA Ci ^ TAAATAC AAAAAGACTG 60 GTTGTGTTCC QGCCGCATCC AACCACGAAG TTGATTTCTC TTQTGTGCAQ AGTOACTGAT 120 TTTAAAQGAC ATCOAGCTTC TCACAATGTC ACAATQTCAO AGTGTGAAGG GCACACTCAC 180 TCCCGCGTGA TTCACATTTA GCAACCAACA ATAGCXCATG AGTCCATACT TGTAAATACT 240 TTTGGCAGAA TAGTTNTTGA AAGTTGCAGA TGATAACTAA GATCCAAGAT ATTTCCCAAA 300 GTAAATAGAA GTGGGTCATA ΑΤΑΤΤΑΑΤΤΛ CCTGTTCACA TCAGCTTCCA TTTACAACTC 360 ATGAGCCCAO ACACTGACAT CAAACTAAGC CCACTTACAC TCCTCACCAC CAQTCTGTCC 420 TGTCATCAGA CAGGAGGCTG TCACCTTGAC CAAATTCTCA CCAGTCAATC ATCTATCCAA 480 AAACCATTAC CTC3ATCCACT TCCGGTAATG CACCACCTTG GTGA 524 -165-This paper size applies the Chinese National Standard (CNS) A4 gauge (210X 297 mm) 1228593 A7 B7 V. Description of the invention (16 °) (2) Information on sequence identification number 209: ⑴ Sequence characteristics: (A ) Length: 159 base pairs (B) Type: Nucleic acid (C) strand : Single strand

(D) Topology: straight line (ii) Molecular type: cDNA (xi) Sequence description: Sequence identification number 209:

GOGTGAGGAA ATCCAGAGTT GOCATGGAGA AAATTCCAGT GTCAC3CATTC TTGCTCCTTG TGGCCCTCTC CTACACTCTO GCCAGAGATA CCACAGTCAA ACCTGGAGCC AAAAAGGACA CAAAGGACTC TCGAGCCAAA CtGCCCCAGA CCCtCTCCA (2) sequence identification number: 256 bases: Type: A Type: Single

(D) Topology: straight line (ii) Molecular type: cDNA (xi) Sequence description: Sequence identification number 210: Printed by the member of the Central Standards Bureau of the Ministry of Economic Affairs, Consumer Cooperative

ACTCCCTGQG AOACAAAGGC AGAGQAGAGA GGTCTGTTAG TTGTGTQTTG TTGAACTGCC ACTOAATTTC TTTCCACtTG GACTATTACA TOCCANTTOA GGOACTAATG GAAAAACGTA tggggagatt ttanccaatt tangtntgta. Aatggggaga ctggggatcagg

TTOCAGGGTG NAAATGGGAN GGCTQGTTTG TTANATGAAG AGGGACATAG GAGGTAGGCA CCAGGATGCT AAATCA (2) Information on sequence identification number 211: ⑴ Sequence features: (A) Length · 264 base pairs (B) Type: Nucleic acid-166- This paper is in accordance with Chinese national standards ( CNS) A4 specification (210X2 ^^ 7 1228593 A7 B7 V. Description of the invention (164) (C) Strand type: single strand (D) Topology: straight line (ii) Molecular type: cDNA (xi) Sequence description: sequence recognition 211 No: ACATTGTTTT TTTGAOATAA AGCATTGAGA GAGCTCTCCT TAACGTGACA CAATGGAAGG 60 ACTGGAACAC ATACCCACAT CTITGMCTG AGGWTAATT TTCTGATAAA GTCTTGCTOT 120 ATATTCAAGO ACATATGTTA TATATTATTC AGTTCCATGT TTATAGCCTA GTTAAGGAGA SEQ ID 1 0 GGGOAGATAC ATTCMGAAAG AGGACTGAAA GAAATACTCA AGTNGGAAAA CAGAAAAAOA 240 AAAAAAGGAG CAAATGAGAA GCCT 264 (2) information at No. 212: ⑴ sEQUENCE cHARACTERISTICS: (A) Length: 328 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology: Straight line (ii) Molecular type: cDNA (xi) Sequence description: Sequence identification number 212:

ACCCAAAAAT CCAATGCTGA ATATTTGGCT TCATTATTCC CANATTCTTT GATTGTCAAA 60 GGATTTAATG TTGTCTCAGC TTGGGCACTT CAGTTAGGAC CTAAGGATGC CAGCCGGCAG 120 GTTTATATAT GCAGCAKGAA TATTCAAGCG CGACAACAGG TTATTGAACT TGCCCGCCAG 1B0 TTNAATTTCA TTCCCATTGA. CTTGGGATCC TTATCATCAG CCAGAGAGAT TGAAAATTTA 240 CCCCTACNAC TCTTTACTCT CTGGANAGGG CCAGTGGTGG TACCTATAAG CTTGGCCACA 300 TTTTTTTTTG CTTTATTCCT TTGTCAGA 32B (Please read the Notes on the back and then fill (This page)

1T. Consumer Cooperative Cooperative Association of the Central Standards Bureau of the Ministry of Economic Affairs (2) Information on sequence identification number 213: ⑴ Sequence characteristics: (A) Length: 250 test base pairs (B) Type: Nucleic acid (C) Stock type: Single (D) Topology: Straight-167-This paper size applies Chinese National Standard (CNS) A4 regulations (210X297 mm) 1228593 A7B7 165) (ii) mOLECULE tYPE: cDNA (xi) sequence Description: SEQ ID NO 213: AGTTATGAGO AGAGGGACAT ATCCNAGTGT AGACTGAATA AAACTGAATT CTCTCGAGTT TAAAGCATTC CTCACTGAA.G GOATAGAAGT GACTGCCAGG AGGGAAAGTA AGCCAA.GGCT CATTATGCCA AAGGANATAT ACATTTCAAT TCTCCAAACT TGTTCCTCAT TCOAAGAGTT ttcaatattt gcatcaacct gctgataanc catgttaana aacaaatatc tgtctnacct tgtcatcgot ( 2) Information on sequence identification number 214: ⑴ Sequence characteristics: (A) Length: 444 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology · Straight line (ii) Molecular type : EDNA [xi] Sequence description: Sequence identification number 214: ACCCAGAATC CAATQCTGAA TATTTGGCTT CATTATTCCC AGATTCTTTG ATTGTCAAAG GATTTAATGT TCTCTCAGCT TGGGCACTTC AGTTAGGACC TAAGGATGCC AGCCGGCAGG TTTATATATG CAOCAACAAT ATTCAAGCGC GACAACAGGT TATTQAAGTT GCCCGCCAGT TGAATTTCAT TCCCATTGAC TTGGGATCCT TATCATCAGC CANAGAGATT GAAAATTTAC CCCTACGACT CTTTACTCTC TGGAGAGGGC CAGTOGTGGT AGCTATAAGC TTGGCCACAT ttttttttcc tttattcctt tgtcagagat gcgattcatc catatgctan aaaccaacag AGTGACTTTT ACAAAATTCC TATAGANATT GTGAATAAAA CCTTACGTAT AGTTGCCATT ACTTTOCTCT CCCTAATATA CCTC (2) SEQ ID information at No. 215: ( i) Sequence characteristics: (A) Length: 366 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D) Topology · Straight line (ii) Molecular type: cDNA (xi) Sequence description: Sequence identification number 215: _____ -166- This paper size is applicable to China National Standard (CNS) A4 (210X297 mm) 2 8 4 5 112 2 2 8 4 0 6 2 4 112 3 3 4 4 (Please read first Notes on the back (this page)

, 1T 1228593 A7 B7 V. Description of the Invention (166) ACTTATG? IGG AGAGCGACAT ATCCAAGTGT ANACTGAATA AAACTGAATT CTCTCCAGTT βΟ TAAAGCATTG CTCACTGA ^ G GGATAGAAGT GACTGCCAGG AGGGAAAGTA AGCCAAGGCT 120 CATTATGCCA AAGGANATAT ACATTTCAAT TGTCCAAACT TGTTCCTCAT TCCAAGAGTT 180 TTCAATATTT GCATGAACCT GCTGATAAGC CATGTTGAGA AACAAATATC TCTCTGACC1T 24 0 TCTCATCGGT AAGCAGAGGC TGTAGGCAAC ATGGACCATA GCGAANAAAA AACTTAGTAA. 300 TCCAAGCTGT TTTCTACACT GTAACCAGGT TTCCAACCAA GGTGGAAATC TCCTATACTT 3 ^ 0 GGTGCC 366 (2) Information on sequence identification number 216: (i) Sequence characteristics: (A) Length: 260 base pairs (B) Type: Nucleic acid (C) shares Type ·· Single-strand (D) Topology: Straight line '(ii) Molecular type ·· cDNA (xi) Sequence description: Sequence identification number 216: CTOTATAAAC AGAACTCCAC TGCANGAGGG AGGGCCGGGC CAGGAGAATC TCCGCTCGTC 60 CAAGACAGGG GCCTAAGGAG CTGGCATCA CTGCTNOTiA GGGCTTTCTA TATCATCA TTNGGCTGGA ΛΛΑ.ΤΤΤΑΑΑΑ ia〇ATCAAAAATT TCCTNAAGTT NTCAAGCTAT CATATATACT NTATCCTGAA AAAGCAACAT 240 AATTGTTCC T TCCCTCGTTT 260. Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs (2) Information on sequence identification number 2Π: ⑴ Sequence characteristics: (A) Length: 262 base pairs (B) Type: Nucleic acid (C) Stock type · Single strand-(D) Topology: Straight line (ii) Molecular type: cDNA (xi) Sequence description: Sequence identification No. 217: ACCTACGTGG GTAAGrTTAN AAATGTTATA ATTTCAGGAA NAGOAACGCA TATAATTGTA ffO TCTTGCCTAT AATTTTGTTGCA CATGAGAG 1GGGGAGTGGG1 GGACAGCACT CAAAAATTTT 1B0 ATGAATAATC TGTATGATTA TATGTCTCTA O ^ GTAGATTT ATAATTAGCC ACTTACCCTA 240 ATATCCTTCA TGCTTGTAAA GT 262 -169-This paper size applies to the Chinese National Standard (CNS) A4 specifications (210X 297 mm) 1228593 kl B7 5. Description of the invention (167) Information on sequence identification number 218: ⑴Sequence features: (A) Length: 205 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand

(D) Topology: Straight line (ii) Molecular type: cDNA (xi) Sequence description: Sequence identification number 218: ACCAAGGTGG TGCATTACCG GAANTGGATC AANGACACCA TCGTGGCCAA CCCCTGAGCA 6〇CCCCTATCAA CTCCCTTTTG TAGTAAACTT GCAACCATCAG CTCAGGTCTCAGCTGCAGAGTCCTAGAGTCGCAGTCTC AGACACAGGT GTAAA 205 (2) Information of sequence identification number 219: (i) Sequence characteristics: (A) Length: 114 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand ((D) Topology: straight line

(ii) Molecular type: cDNA, printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs (xi) Sequence description: Sequence identification No. 219: TACTGTTTTG TCTCAGTAAC AATAAATACA AAAAGACTGG TTOTGTTCCQ GCCCCATCCA 60 ACCACGAAGT TGATTTCTCT TGTGTGCAGA GTGACTQATT TTAAAGGACA TGGA 114 Information: ⑴ Sequence characteristics: (A) Length: 93 test base pairs (B) Type: Nucleic acid-170- This paper size applies Chinese National Standard (CNS) A4 specification (210X 297 mm) 1228593 A7 B7 V. Invention Explanation (168) (C) Share type: single share

(D) Topology: straight line (ii) Molecular type: cDNA (xi) Sequence description: Sequence identification number 220:

ACTAGCCAGC ACAAAAGGCA GGGTAGCCTG AATTGCTTTC TGCTCTTTAC ATTTCTTTTA AAATAAQCAT TTAGTGCTCA GTCCCTACTO AGT (2) Information of sequence identification number 221: ⑴ Sequence characteristics: (A) Length: 167 base pairs (B) Type: Nucleic acid (C) Stock type: Single strand

(D) Topology: straight line (ii) Molecular type: cDNA (xi) Sequence description: Sequence identification number 221:

ACTANGTGCA GGTGCGCACA AATATTTOTC GATATTCCCT TCATCTTGGA TTCCATGAGG TCTTTTGCCC AGCCTQTGGC TCTACTGTAG TAAGTTTCTG CTOATGAGOA GCCAGNATGC CCCCCACTAC CTTCCGTGAC GCTCCCCANA AATCACCCAA CCTCTGT (2) sequence identification number: 222 base sequence number 222 base number information: 222 base sequence number 222 Printed by Employee Consumption Cooperative (B) Type: Nucleic Acid (C) Stock Type: Single Stock (D) Topology: Straight

(ii) Molecular type: cDNA (xi) Sequence description: Sequence identification number 222: «171- --- _ This paper size applies to China National Standard (CNS) A4 specification (210X297 mm) 1228593 A7 B7 V. Description of the invention ( 169

AGGGCGTGGT GTTCTTCACC ATGTTTGCTG TTTTCTGTTT TAGGTOAGCA CTCGTATCAA

GCGGAGGGCG TGTCCCCCAA AATTAAAGGA TATATTTCTA TGATTAGAGA AACAATAGAT GTACTGACCT TCCTTAAAAG tggatgaaaa GAAjGAAGTTT GCTTGTAGGT TGGTAAAGCt

CATTAGTAGG GCCATACTGC AAATTAATAA CTTTGAGCCT TGCTTTTACA GGTATTATTO

AGGATGCATT ATAAAGTCAA TGAATTTTTG ATTAGATCCC TATATCTGGC TATTGATAAG

CTGGCAGCCC CAACAGATAA CATAATCCAA GGGAATCTTT ATATTTGAGT T ¢ 0 120 1Θ0 240 300 351 (2) Information of sequence identification number 223: ⑴ Sequence characteristics: (A) Length: 383 base pairs (B) Type: Nucleic acid (C) Stock type: Single Stock (D) Topology: Line (xi) Sequence Description: Sequence Identification No. 223:

AAAAGAAACA TGGTAATTAT TTAAAATGTC TGCCAAAGGA TAAAAGATTT ATAGGACCAC ACCATTAAGC

AACAAAAAAA αατοΑΑτττΑ T? QTGCCAAAA AGTCTAAGGA TGATTXCCTG AGTCTTCACT TATATGTTTA

ACAATTCTTC ATTCAGA7VAA ATTATCTTAG GGACTGATAT ATWRTRTTKT GCGGCATTTC CTTAC! ATTGT CTTGACAAGA TTTTGTATTT TATTTGGAGA CTTCTTATCA AAAGTAATGG ATTA3TAGTG TTCCCMTCAG TTGTTTGGAG TGTGCTATTC GAATGACAAT TATATTTTftA CTTTGGTGCC5 GGAAMAOTT TGTGATACTT GTAT ^ TTAAT CTTTTA.TTGC ACTTGTTTTG 601201Θ0 240300 360 3Θ3, Ministry of Economic Affairs Bureau of Standards staff printed consumer cooperatives

(2) Information on sequence identification number 224: (i) Sequence characteristics: (A) Length: 320 base pairs (B) Type: Nucleic acid (C) Strand type: Single strand (D &gt; Topology: Straight line (xi) sequence Description: SEQ ID NO 224: CCCCTGAAGG CTTCTTGTTA GAAAATAGTA CAGTTACAAG CAATAGGAAC AACAAAAAGA AAAAOTTTGT GACATTGTAO TAGGGAGTGT GTACCCCTf A CTCCCCATCA ΑΑΑΑΑΑΑΑΑΤ gqatacatgg ttaaaggata raaqggcaat attttatcat atgttctaaa agagaaggaa gagaaaatac tactttctcr aaatggaagc ccttaaaggt gctttgatac tgaaggacac aaatgtggcc GTCCATCCTC CTTXARAGTT gcatgacttg gacacggtaa ctgttgcagt TTTAHACTCM GCATTGTOAC 60120180 240300320 -172 scale applies present paper China National Standard (CNS) A4 Specification (210X297 mm)

Claims (1)

1228! County Patent No. 02741 Chinese Patent Application Replacement (October 1993) 8 8 8 8 A B c D 93 · ια is amended ♦ λ «V:. 1 Patent application scope 1. A method for detecting prostate cancer in a patient, comprising: (a) obtaining a biological sample from the patient; (b) subjecting the sample to at least two oligonuclei in a polymerase chain reaction The fenamic acid primer contacts, at least one of which is an oligonucleotide primer comprising at least about 10 adjacent nuclei of a DNA molecule having a sequence selected from the group consisting of sequence identification numbers: 10, 11 and 1 10 (C) detecting the amplified DNA sequence in the presence of the oligo: y: acid primer in the sample to detect prostate cancer; wherein the sequence identification number: 10, 11, 110 is as follows As shown in: SEQ ID NO: CAGTCTATNT GGCCAGTGTG ACAGTGTGGC CGTGGTGACA AGATCCTGCC CTACACACTG AATACCGAGG GGACACTGGA CAGGCCCTAA GCCTGGAGCT TGCTCCCACC TCCACCCGCG TGGTGGGTGA GCCCACCGAN CCATCCTGGA TAGTGCTTCC TGTCCAGCTC AGCCAGTCTG CCCATTTACT TTGCTACACA TTAAAAAATT TCCTGTTAAC GTGGCTCTCT GGNGTTCCC CCAGCAACAT CCCATGGGGC GCTGCCACCT 10: GCAGCTTTCC GCTTCAGCCG GCCTCCCTCT GGTGCTAGCA CCCTTCCCTA CTCTGCGGGG GCCAGGGTGG TGCTGTCCCA TC ACTGCCTA GGTANTATTT TGGGGGTGGA TGCCGGCTTG GTTGCTGGCT CTGTGGCTGC CCCTCACCGG ACCACCGGGA GTGAGGACAG ATGGACACGT CCTCTGCCTG TTCCGGGCCG NGTGGCCCCA TATGGTGTCT GACAAGAACG AGGCCTGCCT GCCGCCAATT GAAGTGCNTA CGGTGCCACA GTTCACCTTC GAAGCAGGTG CCTGATGACC GGGTGCTGGA TGATGTCTCC GGGCATCTGC TCCCTGTTTA GCCGCAGGCC ANTTGGCCAA CACTGGGTCC TCTGTTGCTG CNGCNCANCT TGCCTGTCCC TCAGCCCTGC TTCCTGCCCA AGCTTCCTGC GGCAGTGGCC GTACGTGTGG CTGGACCTCG TGGGCTCCAT TGGGTCTGGT ATACTCAGCG AACTCCCCGC CCAAANTNAT NGGGGGGTNG 60 120 180 240 300 360 420 480 540 600 660 720 780 789 SEQ ID NO: CCCACCCTAC CCAAATATTA TTTGTTAAAT AAATAAGTTA ACCAACAGGC CACATCCTGA TGTGGGCTGA GGGGACCTGG ACTTTCATAT GTTCAAATCC CTACATTAAA CGAAGCTGCA TATTCAGCTC CCAAAAACCC CTGAGCCTGG GTAATCCACC CTCCCTGTAT AAGTCCAGAC AACTGGGGAA AAAAGAAAAG GCACAGGGTG GCAGCAAAAA ACCCCGGCAC CCCNANGGGG GGCCCNCCAC CCCNAATNTT 11: GACACCAACA AATATTTAAA TAAAAGGTAA TTCTTGTGTG CATGGAGGAG GGTTAAGGGG TTCTCTAGGT TGCAGAGTCC TGAAACCCCC GACGCCC CAN AACCACTTTA GTTAACAGGA GCTGGGAAAT CAGAAAAGCT TGCCTGTGTC GAGGGGGGTG TTGCCCCTCA TGTTTCATCC CTTANAGATG GTGTCTCAAC CCGCATTCCA TTGGAAGGNC CCCCCAGCTG CTTTGGCACA ANCNGGGNAA TTTTCCTCCC AGCAATGGAT TCTGTGATGG GATCAGCAAA GGACTCTTCC TAGAAACTCC GGAAACCAGG TAGGAGGCTA GTGCATGGAA TCCAGTCAGG TGCANCTACG AACAAAAACT CNTGGAACCC CTAAATTNTT TCCCTTCTAC CAACAGAAGG AAGACAGTGC CCTACAAATA CATGCAAGAG TGACTGAGTT GCTGTTAACC CCCTTCTGGC CAGCCCTANA CACCTCAACA NGGGGGGGCA AATTNAGGCA TC 60 120 180 240 300 360 420 480 540 600 660 720 772 SEQ ID NO: GGGAACCAGC CTGCACGCGC GTGATGAGAC GTGTCCCCAC AAGCTGGACC GGCACCAAAG GGCGGCAGCA AGGAGGAGAG GAGTGCCTGA ACGGCCCCCT GGTGAGCCGC CTGCTGCGGC TGGCCTGGAG GTGTGTTTGG GGGGGTAGAG GAGAAGTTCA CTGTGTCCCG CTCCTAGGCT GCCCTTCATC TGGGCACTGT 110: TGGCTCCGGG TGAGGTGCCC GGCTGGCAGA GCCGCAGCTT GAGCCCTACC ACCGGAAAGC CCGCAGGCAT TGACCATGGT CAGCCAGTGA CCTTGGGCAT TGACAGCCGC CACAGCAGCA AATGGGCGCC CTGGAGCAGA CGCCTGGCCC CCAGCTCTTG CACCTATGTG GCTGG GCATT CCACTGGCGT CCTGCTGAGC GCGCCTCGGC GGTGTTGAGC TGGCTGATTC GCCGAGACGA ACTATGGTCC CTGGTCAACC CCGCCTCTGC GGTCCAGTGC GGACGCTATG CTCTTTCTCA CAGGATCTGA ATGGGCTGAG CTAGGCAGTT AGCAGTTCTG AGAGGCTGTG TGCTAACCTT. TGCTGGAAGT TGGGCCTGGT GCCGCCGCCG TCCCAAGGGC 60 120 180 240 300 360 420 480 540 600 52031-931015.DOC present paper applies the Chinese national standard scale (CNS) A4 Specifications (210 X 297 mm) 8 8 8 8 AB c D 1228593 々, patent application scope 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1740 1800 1860 1920 1980 2040 2100 2160 220 2280 2340 2400 2460 2520 2580 2640 2700 2760 2820 2880 2940 3000 3060 3120 3180 3240 3300 3360 3410 CGGCTGGCTA GCAGGG.CTGC TGTGCCCGGA TCCCAGGCCC CTGGAGCTGG CACTGCTCAT CCTGGGCGTG GGGCTGCTGG ACTTCTGTGG CCAGGTGTGC TTCACTCCAC TGGAGGCCCT GCTCTCTGAC CTCTTCCGGG ACCCGGACCA CTGTCGCCAG GCCTACTCTG TCTATGCCTT CATGATCAGT CTTGGGGGCT GCCTGGGCTA CCTCCTGCCT GCCATTGACT GGGACACCAG TGCCCTGGCC CCCTACCTGG GCACCCAGGA GGAGTGCCTC TTTGGCC TGC TCACCCTCAT CTTCCTCACC TGCGTAGCAG CCACACTGCT GGTGGCTGAG GAGGCAGCGC TGGGCCCCAC CGAGCCAGCA GAAGGGCTGT CGGCCCCCTC CTTGTCGCCC CACTGCTGTC CATGCCGGGC CCGCTTGGCT TTCCGGAACC TGGGCGCCCT GCTTCCCCGG CTGCACCAGC TGTGCTGCCG CATGCCCCGC ACCCTGCGCC GGCTCTTCGT GGCTGAGCTG TGCAGCTGGA TGGCACTCAT GACCTTCACG CTGTTTTACA CGGATTTCGT GGGCGAGGGG CTGTACCAGG GCGTGCCCAG AGCTGAGCCG GGCACCGAGG CCCGGAGACA CTATGATGAA GGCGTTCGGA TGGGCAGCCT GGGGCTGTTC CTGCAGTGCG CCATCTCCCT GGTCTTCTCT CTGGTCATGG ACCGGCTGGT GCAGCGATTC GGCACTCGAG CAGTCTATTT GGCCAGTGTG GCAGCTTTCC CTGTGGCTGC CGGTGCCACA TGCCTGTCCC ACAGTGTGGC CGTGGTGACA GCTTCAGCCG CCCTCACCGG GTTCACCTTC TCAGCCCTGC AGATCCTGCC CTACACACTG GCCTCCCTCT ACCACCGGGA GAAGCAGGTG TTCCTGCCCA AATACCGAGG GGACACTGGA GGTGCTAGCA GTGAGGACAG CCTGATGACC AGCTTCCTGC CAGGCCCTAA GCCTGGAGCT CCCTTCCCTA ATGGACACGT GGGTGCTGGA GGCAGTGGCC TGCTCCCACC TCCACCCGCG CTCTGCGGGG CCTCTGCCTG TGATGTCTCC GTACGTGTGG TGGTGGGTGA GCCCACCGAG GCCAGGGTGG TTCCGGGCCG GGGCATCTGC CTGGACCTCG CCATCCTGGA TAGTGCCTTC CTGCTGTCCC AGGTGG CCCC ATCCCTGTTT ATGGGCTCCA TTGTCCAGCT CAGCCAGTCT GTCACTGCCT ATATGGTGTC TGCCGCAGGC CTGGGTCTGG TCGCCATTTA CTTTGCTACA CAGGTAGTAT TTGACAAGAG CGACTTGGCC AAATACTCAG CGTAGAAAAC TTCCAGCACA TTGGGGTGGA GGGCCTGCCT CACTGGGTCC CAGCTCCCCG CTCCTGTTAG CCCCATGGGG CTGCCGGGCT GGCCGCCAGT TTCTGTTGCT GCCAAAGTAA TGTGGCTCTC TGCTGCCACC CTGTGCTGCT GAGGTGCGTA GCTGCACAGC TGGGGGCTGG GGCGTCCCTC TCCTCTCTCC CCAGTCTCTA GGGCTGCCTG ACTGGAGGCC TTCCAAGGGG GTTTCAGTCT GGACTTATAC AGGGAGGCCA GAAGGGCTCC ATGCACTGGA ATGCGGGGAC TCTGCAGGTG GATTACCCAG GCTCAGGGTT AACAGCTAGC CTCCTAGTTG AGACACACCT AGAGAAGGGT TTTTGGGAGC TGAATAAACT CAGTCACCTG GTTTCCCATC TCTAAGCCCC TTAACCTGCA GCTTCGTTTA ATGTAGCTCT TGCATGGGAG TTTCTAGGAT GAAACACTCC TCCATGGGAT TTGAACATAT GACTTATTTG TAGGGGAAGA GTCCTGAGGG GCAACACACA AGAACCAGGT CCCCTCAGCC CACAGCACTG TCTTTTTGCT GATCCACCCC CCTCTTACCT TTTATCAGGA TGTGGCCTGT TGGTCCTTCT GTTGCCATCA CAGAGACACA GGCATTTAAA TATTTAACTT ATTTATTTAA CAAAGTAGAA GGGAATCCAT TGCTAGCTTT TCTGTGTTGG TGTCTAATAT TTGGGTAGGG TGGGGGATCC CCAACAATCA GGTCC CCTGA GATAGCTGGT CATTGGGCTG ATCATTGCCA GAATCTTCTT CTCCTGGGGT CTGGCCCCCC AAAATGCCTA ACCCAGGACC TTGGAAATTC TACTCATCCC AAATGATAAT TCCAAATGCT GTTACCCAAG GTTAGGGTGT TGAAGGAAGG TAGAGGGTGG GGCTTCAGGT CTCAACGGCT TCCCTAACCA CCCCTCTTCT CTTGGCCCAG CCTGGTTCCC CCCACTTCCA CTCCCCTCTA CTCTCTCTAG GACTGGGCTG ATGAAGGCAC TGCCCAAAAT TTCCCCTACC CCCAACTTTC CCCTACCCCC AACTTTCCCC ACCAGCTCCA CAACCCTGTT TGGAGCTACT GCAGGACCAG AAGCACAAAG TGCGGTTTCC CAAGCCTTTG TCCATCTCAG CCCCCAGAGT ATATCTGTGC TTGGGGAATC TCACACAGAA ACTCAGGAGC ACCCCCTGCC TGAGCTAAGG GAGGTCTTAT CTCTCAGGGG GGGTTTAAGT GCCGTTTGCA ATAATGTCGT CTTATTTATT TAGCGGGGTG AATATTTTAT ACTGTAAGTG AGCAATCAGA GTATAATGTT TATGGTGACA AAATTAAAGG CTTTCTTATA TGTTTAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA Self-sequence identification number: at least about 10 of the sequence of DNA molecules in the group of 10, 11 and 1 10 Adjacent nucleotides; Wherein the sequence identification number: 10, 11, 110 The sequence is as follows: SEQ ID NO: 1 0: CAGTCTATNT GGCCAGTGTG GCAGCTTTCC CTGTGGCTGC CGGTGCCACA TGCCTGTCCC 60 ACAGTGTGGC CGTGGTGACA GCTTCACAGCCGACCTAGGGTGTCACCTTC TCAGCCCTGCGCCT ACCT AATACCGAGG GGACACTGGA GGTGCTAGCA GTGAGGAGAG CCTGATGACC AGCTTCCTGC 240 CAGGCCCTAA GCCTGGAGCT CCCTTCCCTA ATGGACACGT GGGTGCTGGA GGCAGTGGCC 300 TGCTCCCACC TCCACCCGCG CTCTGCGG8CC (China standard 8OCXCG standard CGCCGTCG-GCCTCGC-CCC-GCC-GCC-GCC-CCC-GCC-GCC-GCC-GCC-GCC-GCC-GCC) 8 ABCD 1228593, patented scope TGGTGGGTGA GCCCACCGAN GCCAGGGTGG TTCCGGGCCG GGGCATCTGC CTGGACCTCG 420 CCATCCTGGA TAGTGCTTCC TGCTGTCCCA NGTGGCCCCA TCCCTGTTTA TGGGCTCCAT 480 TGTCCAGCTC AGCCAGTCTG TCACTGCCTA TATGGTGTCT GCCGCAGGCC TGGGTCTGGT 540 CCCATTTACT TTGCTACACA GGTANTATTT GACAAGAACG ANTTGGCCAA ATACTCAGCG 600: TTAAAAAATT CCAGCAACAT TGGGGGTGGA AGGCCTGCCT CACTGGGTCC AACTCCCCGC 660 TCCTGTTAAC CCCATGGGGC TGCCGGCTTG GCCGCCAATT TCTGTTGCTG CCAAANTNAT 720 GTGGCTCTCT GCTGCCACCT GTTGCTGGCT GAAGTGCNTA CNGCNCANCT NGGGGGGTNG 780 GGNGTTCCC 789 SEQ ID NO: 1 1: CCCACCCTAC CCAAATATTA GACACCAACA CAGAAAAGCT AGCAATGGAT TCCCTTCTAC 60 TTTGTTAAAT AAATAAGTTA AATATTTAAA TGCCTGTGTC TCTGTGATGG CAACAGAAGG 120 ACCAACAGGC CACATCCTGA TAAAAGGTAA GAGGGGGGTG GATCAGCAAA AAGACAGTGC 180 TGTGGGCTGA GGGGACCTGG TTCTTGTGTG TTGCCCCTCA GGACTCTTCC CCTACAAATA 240 ACTTTCATAT GTTCAAATCC CATGGAGGAG TGTTTCATCC TAGAAACTCC CATGCAAGAG 300 CTACATTAAA CGAAGCTGCA GGTTAAGGGG CTTANAGATG GGAAACCAGG TGACTGAGTT 360 TATTCAGCTC CCAAAAACCC TTCTCTAGGT GTGTCTCAAC TAGGAGGCTA GCTGTTAACC 420 CTGAGCCTGG GTAATCCACC TGCAGAGTCC CCGCATTCCA GTGCATGGAA CCCTTCTGGC 480 CTCCCTGTAT AAGTCCAGAC TGAAACCCCC TTGGAAGGNC TCCAGTCAGG CAGCCCTANA 540 AACTGGGGAA AAAAGAAAAG GACGCCCCAN CCCCCAGCTG TGCANCTACG CACCTCAACA 600 GCACAGGGTG GCAGCAAAAA AACCACTTTA CTTTGGCACA AACAAAAACT NGGGGGGGCA 660 ACCCCGGCAC CCCNA NGGGG GTTAACAGGA ANCNGGGNAA CNTGGAACCC AATTNAGGCA 720 GGCCCNCCAC CCCNAATNTT GCTGGGAAAT TTTTCCTCCC CTAAATTNTT TC 772 SEQ ID NO: 1 1 0: GGGAACCAGC CTGCACGCGC TGGCTCCGGG TGACAGCCGC GCGCCTCGGC CAGGATCTGA 60 GTGATGAGAC GTGTCCCCAC TGAGGTGCCC CACAGCAGCA GGTGTTGAGC ATGGGCTGAG 120 AAGCTGGACC GGCACCAAAG GGCTGGCAGA AATGGGCGCC TGGCTGATTC CTAGGCAGTT 180 GGCGGCAGCA AGGAGGAGAG GCCGCAGCTT CTGGAGCAGA GCCGAGACGA AGCAGTTCTG 240 GAGTGCCTGA ACGGCCCCCT GAGCCCTACC CGCCTGGCCC ACTATGGTCC AGAGGCTGTG 300 GGTGAGCCGC CTGCTGCGGC ACCGGAAAGC CCAGCTCTTG CTGGTCAACC TGCTAACCTT 360 TGGCCTGGAG GTGTGTTTGG CCGCAGGCAT CACCTATGTG CCGCCTCTGC TGCTGGAAGT 420 GGGGGTAGAG GAGAAGTTCA TGACCATGGT GCTGGGCATT GGTCCAGTGC TGGGCCTGGT 480 CTGTGTCCCG CTCCTAGGCT CAGCCAGTGA CCACTGGCGT GGACGCTATG GCCGCCGCCG 540 GCCCTTCATC TGGGCACTGT CCTTGGGCAT CCTGCTGAGC CTCTTTCTCA TCCCAAGGGC 600 CGGCTGGCTA GCAGGGCTGC TGTGCCCGGA TCCCAGGCCC CTGGAGCTGG CACTGCTCAT 660 CCTGGGCGTG GGGCTGCTGG ACTTCTGTGG CCAGGTGTGC TTCACTCCAC TGGAGGCCCT 720 GCTCTCTGAC C TCTTCCGGG ACCCGGACCA CTGTCGCCAG GCCTACTCTG TCTATGCCTT 780 CATGATCAGT CTTGGGGGCT GCCTGGGCTA CCTCCTGCCT GCCATTGACT GGGACACCAG 840 TGCCCTGGCC CCCTACCTGG GCACCCAGGA GGAGTGCCTC TTTGGCCTGC TCACCCTCAT 900 CTTCCTCACC TGCGTAGCAG CCACACTGCT GGTGGCTGAG GAGGCAGCGC TGGGCCCCAC 960 CGAGCCAGCA GAAGGGCTGT CGGGCCCCTC CTTGTCGCCC CACTGCTGTC CATGCCGGGC 1020 CCGCTTGGCT TTCCGGAACC TGGGCGCCCT GCTTCCCCGG CTGCACCAGC TGTGCTGCCG 1080 CATGCCCCGC ACCCTGCGCC GGCTCTTCGT GGCTGAGCTG TGCAGCTGGA TGGCACTCAT 1140 GACCTTCACG CTGTTTTACA CGGATTTCGT GGGCGAGGGG CTGTACCAGG GCGTGCCCAG 1200 AGCTGAGCCG GGCACCGAGG CCCGGAGACA CTATGATGAA GGCGTTCGGA TGGGCAGCCT 1260 GGGGCTGTTC CTGCAGTGCG CCATCTCCCT GGTCTTCTCT CTGGTCATGG ACCGGCTGGT 1320 GCAGCGATTC GGCACTCGAG CAGTCTATTT GGCCAGTGTG GCAGCTTTCC CTGTGGCTGC 1380 CGGTGCCACA TGCCTGTCCC ACAGTGTGGC CGTGGTGACA GCTTCAGCCG CCCTCACCGG 1440 GTTCACCTTC TCAGCCCTGC AGATCCTGCC CTACACACTG GCCTCCCTCT ACCACCGGGA 1500 GAAGCAGGTG TTCCTGCCCA AATACCGAGG GGACACTGGA GGTGCTAGCA GTGAGGACAG 1560 CCTGATGA CC AGCTTCCTGC CAGGCCCTAA GCCTGGAGCT CCCTTCCCTA ATGGACACGT 1620 GGGTGCTGGA GGCAGTGGCC TGCTCCCACC TCCACCCGCG CTCTGCGGGG CCTCTGCCTG 1680 TGATGTCTCC GTACGTGTGG TGGTGGGTGA GCCCACCGAG GCCAGGGTGG TTCCGGGCCG 1740 GGGCATCTGC CTGGACCTCG CCATCCTGGA TAGTGCCTTC CTGCTGTCCC AGGTGGCCCC 1800 ATCCCTGTTT ATGGGCTCCA TTGTCCAGCT CAGCCAGTCT GTCACTGCCT ATATGGTGTC 1860 TGCCGCAGGC CTGGGTCTGG TCGCCATTTA CTTTGCTACA CAGGTAGTAT TTGACAAGAG 1920 CGACTTGGCC AAATACTCAG CGTAGAAAAC TTCCAGCACA TTGGGGTGGA GGGCCTGCCT 1980 CACTGGGTCC CAGCTCCCCG CTCCTGTTAG CCCCATGGGG CTGCCGGGCT GGCCGCCAGT 2040 TTCTGTTGCT GCCAAAGTAA TGTGGCTCTC TGCTGCCACC CTGTGCTGCT GAGGTGCGTA 2100 GCTGCACAGC TGGGGGCTGG GGCGTCCCTC TCCTCTCTCC CCAGTCTCTA GGGCTGCCTG 2160 ACTGGAGGCC TTCCAAGGGG GTTTCAGTCT GGACTTATAC AGGGAGGCCA GAAGGGCTCC 2220 ATGCACTGGA ATGCGGGGAC TCTGCAGGTG GATTACCCAG GCTCAGGGTT AACAGCTAGC 2280 CTCCTAGTTG AGACACACCT AGAGAAGGGT TTTTGGGAGC TGAATAAACT CAGTCACCTG 2340 GTTTCCCATC TCTAAGCCCC TTAACCTGCA GCTTCGTTTA ATGTAGCTCT TGCATGGGAG 2400 TTTCTAGGAT GAAACACTCC TCCATGGGAT TTGAACATAT GACTTATTTG TAGGGGAAGA 2460 GTCCTGAGGG GCAACACACA AGAACCAGGT CCCCTCAGCC CACAGCACTG TCTTTTTGCT '2520 GATCCACCCC CCTCTTACCT TTTATCAGGA TGTGGCCTGT TGGTCCTTCT GTTGCCATCA 2580 CAGAGACACA GGCATTTAAA TATTTAACTT ATTTATTTAA CAAAGTAGAA GGGAATCCAT 2640 TGCTAGCTTT TCTGTGTTGG TGTCTAATAT TTGGGTAGGG TGGGGGATCC CCAACAATCA 2700 52031-931015.DOC - 3 - This paper applies China National Scale standard (CNS) A4 size (210 X 297 mm) 8 8 8 8 A BCD 1228593 々, patented scope GGTCCCCTGA GATAGCTGGT CATTGGGCTG ATCATTGCCA GAATCTTCTT CTCCTGGGGT 2760 CTGGCCCCCC AAAATGCCTA ACCCAGGACC TTGGAAATTC TACTCATCCC AAATGATAAT 2820 TCCAAATGCT GTTACCCAAG GTTAGGGTGT TGAAGGAAGG TAGAGGGTGG GGCTTCAGGT 2880 CTCAACGGCT TCCCTAACCA CCCCTCTTCT CTTGGCCCAG CCTGGTTCCC CCCACTTCCA 2940 CTCCCCTCTA CTCTCTCTAG GACTGGGCTG ATGAAGGCAC TGCCCAAAAT TTCiCCCTACC 3000 CCCAACTTTC CCCTACCCCC AACTTTCCCC ACCAGCTCCA CAACCCTGTT TGGAGCTACT 3060 GCAGGACCAG AAGCACAAAG TGCGGTTTCCCAAGTC T 3120 ATATCTGTGC TTGGGGAATC TCACACAGAA ACTGAGGAGC ACCCCCTGCC TGAGCTAAGG 3180 GAGGTCTTAT CTCTCAGGGG GGGTTTAAGT GCCGTTTGCA ATAATGTCGT CTTATTTATT 3240 TAGCGGGGTG AATATTTTAT ACTGTAAGTG AGCAATCAGA GTATAATGTT TATGGTGACA 3300 AAATTAAAGG CTTTCTTATA TGTTTAAAAA ΑΑΑΑΆΑΑΑΑΑ AAAAAAAAAA AAAAAAAAAA 3360 AAAAAAAARA AAAAAAAAAA AAAAAAAAAA AAAAAAATAA AAAAAAAAAA 3410 3. - kind of method of detecting prostate cancer in a patient Including: (a) obtaining a biological sample from the patient; (b) contacting the biological sample with an oligonucleotide probe, wherein the oligonucleotide probe comprises a compound having a sequence identification number selected from the group of 10 1 At least about 15 adjacent nucleotides of a DNA molecule of the group consisting of 1, 11, and 10; and (c) detecting in the sample that hybridizes with the oligonucleotide probe DNA sequence to detect prostate cancer in patients; where the sequence identification numbers: 10, 11, 110 are as follows: SEQ ID NO: 1 0: CAGTCTATNT GGCCAGTGTG GCAGCTTTCC CTGTGGCTGC CGGTGCCACA TGCCTGTCCC 60 ACAGTGTGGC CGTGGTGACA GCTTCAGCCG C CCTCACCGG GTTCACCTTC TCAGCCCTGC 120 AGATCCTGCC CTACACACTG GCCTCCCTCT ACCACCGGGA GAAGCAGGTG TTCCTGCCCA 180 AATACCGAGG GGACACTGGA GGTGCTAGCA GTGAGGACAG CCTGATGACC AGCTTCCTGC 240 CAGGCCCTAA GCCTGGAGCT CCCTTCCCTA ATGGACACGT GGGTGCTGGA GGCAGTGGCC 300 TGCTCCCACC TCCACCCGCG CTCTGCGGGG CCTCTGCCTG TGATGTCTCC GTACGTGTGG 360 TGGTGGGTGA GCCCACCGAN GCCAGGGTGG TTCCGGGCCG GGGCATCTGC CTGGACCTCG 420 CCATCCTGGA TAGTGCTTCC TGCTGTCCCA NGTGGCCCCA TCCCTGTTTA TGGGCTCCAT 480 TGTCCAGCTC AGCCAGTCTG TCACTGCCTA TATGGTGTCT GCCGCAGGCC TGGGTCTGGT 540 CCCATTTACT TTGCTACACA GGTANTATTT GACAAGAACG ANTTGGCCAA ATACTCAGCG 600 ΤΤΑΑΑΑΆΑΤΤ CCAGCAACAT TGGGGGTGGA AGGCCTGCCT CACTGGGTCC AACTCCCCGC 660 TCCTGTTAAC CCCATGGGGC TGCCGGCTTG GCCGCCAATT TCTGTTGCTG CCAAANTNAT 720 GTGGCTCTCT GCTGCCACCT GTTGCTGGCT GAAGTGCNTA CNGCNCANCT NGGGGGGTNG 780 GGNGTTCCC 789 SEQ ID NO: 1 1: CCCACCCTAC CCAAATATTA GACACCAACA CAGAAAAGCT AGCAATGGAT TCCCTTCTAC 60 TTTGTTAAAT AAATAAGTTA AATATTTAAA TGCCTGTGTC TCTGTGATGG CAACAGAAGG 12 0 ACCAACAGGC CACATCCTGA TAAAAGGTAA GAGGGGGGTG GATCAGCAAA AAGACAGTGC 180 TGTGGGCTGA GGGGACCTGG TTCTTGTGTG TTGCCCCTCA GGACTCTTCC CCTACAAATA 240 ACTTTCATAT GTTCAAATCC CATGGAGGAG TGTTTCATCC TAGAAACTCC CATGCAAGAG 300 CTACATTAAA CGAAGCTGCA GGTTAAGGGG CTTANAGATG GGAAACCAGG TGACTGAGTT 360 TATTCAGCTC CCAAAAACCC TTCTCTAGGT GTGTCTCAAC TAGGAGGCTA GCTGTTAACC 420 CTGAGCCTGG GTAATCCACC TGCAGAGTCC CCGCATTCCA GTGCATGGAA CCCTTCTGGC 480 CTCCCTGTAT AAGTCCAGAC TGAAACCCCC TTGGAAGGNC TCCAGTCAGG CAGCCCTANA 540 AACTGGGGAA AAAAGAAAAG GACGCCCCAN CCCCCAGCTG TGCANCTACG CACCTCAACA 600 GCACAGGGTG GCAGCAAAAA AACCACTTTA CTTTGGCACA AACAAAAACT NGGGGGGGCA 660 ACCCCGGCAC CCCNANGGGG GTTAACAGGA ANCNGGGNAA CNTGGAACCC AATT31GGCA520 Standard 520 China National Standard-520 ACN 520-520 8 8 ABCD 1228593 々, patent application scope GGCCCNCCAC CCCNAATNTT GCTGGGAAAT TTTTCCTCCC CTAAATTNTT TC SEQ ID NO: 1 1 0: GGGAACCAGC CTGCACGCGC TGGCTCCGGG TGACAGCCGC GCGCCTCGGC C AGGATCTGA 60 GTGATGAGAC GTGTCCCCAC TGAGGTGCCC CACAGCAGCA GGTGTTGAGC ATGGGCTGAG 120 AAGCTGGACC GGCACCAAAG GGCTGGCAGA AATGGGCGCC TGGCTGATTC CTAGGCAGTT 180 GGCGGCAGCA AGGAGGAGAG GCCGCAGCTT CTGGAGCAGA GCCGAGACGA AGCAGTTCTG 240 GAGTGCCTGA ACGGCCCCCT GAGCCCTACC CGCCTGGCCC ACTATGGTCC AGAGGCTGTG 300 GGTGAGCCGC CTGCTGCGGC ACCGGAAAGC CCAGCTCTTG CTGGTCAACC TGCTAACCTT 360 TGGCCTGGAG GTGTGTTTGG CCGCAGGCAT CACCTATGTG CCGCCTCTGC TGCTGGAAGT 420 GGGGGTAGAG GAGAAGTTCA TGACCATGGT GCTGGGCATT GGTCCAGTGC TGGGCCTGGT 480 CTGTGTCCCG CTCCTAGGCT CAGCCAGTGA CCACTGGCGT GGACGCTATG GCCGCCGCCG 540 GCCCTTCATC TGGGCACTGT CCTTGGGCAT CCTGCTGAGC CTCTTTCTCA TCCCAAGGGC 600 CGGCTGGCTA GCAGGGCTGC TGTGCCCGGA TCCCAGGCCC CTGGAGCTGG CACTGCTCAT 660 CCTGGGCGTG GGGCTGCTGG ACTTCTGTGG CCAGGTGTGC TTCACTCCAC TGGAGGCCCT 720 GCTCTCTGAC CTCTTCCGGG ACCCGGACCA CTGTCGCCAG GCCTACTCTG TCTATGCCTT 780 CATGATCAGT CTTGGGGGCT GCCTGG'GCTA CCTCCTGCCT GCCATTGACT GGGACACCAG 840 TGCCCTGGCC CCCTACCTGG GCACCCAGGA GGAGTGCCTC TTTGGCCTGC TCACCCT CAT 900 CTTCCTCACC TGCGTAGCAG CCACACTGCT GGTGGCTGAG GAGGCAGCGC TGGGCCCCAC 960 CGAGCCAGCA GAAGGGCTGT CGGCCCCCTC CTTGTCGCCC CACTGCTGTC CATGCCGGGC 1020 CCGCTTGGCT TTCCGGAACC TGGGCGCCCT GCTTCCCCGG CTGCACCAGC TGTGCTGCCG 1080 CATGCCCCGC ACCCTGCGCC GGCTCTTCGT GGCTGAGCTG TGCAGCTGGA TGGCACTCAT 1140 GACCTTCACG CTGTTTTACA CGGATTTCGT GGGCGAGGGG CTGTACCAGG GCGTGCCCAG 1200 AGCTGAGCCG GGCACCGAGG CCCGGAGACA CTATGATGAA GGCGTTCGGA TGGGCAGCCT 1260 GGGGCTGTTC CTGCAGTGCG CCATCTCCCT GGTCTTCTCT CTGGTCATGG ACCGGCTGGT 1320 GCAGCGATTC GGCACTCGAG CAGTCTATTT GGCCAGTGTG GCAGCTTTCC CTGTGGCTGC 13S0 CGGTGCCACA TGCCTGTCCC ACAGTGTGGC CGTGGTGACA GCTTCAGCCG CCCTCACCGG 1440 GTTCACCTTC TCAGCCCTGC AGATCCTGCC CTACACACTG GCCTCCCTCT ACCACCGGGA 1500 GAAGCAGGTG TTCCTGCCCA AATACCGAGG GGACACTGGA GGTGCTAGCA GTGAGGACAG 1560 CCTGATGACC AGCTTCCTGC CAGGCCCTAA GCCTGGAGCT CCCTTCCCTA ATGGACACGT 1620 GGGTGCTGGA GGCAGTGGCC TGCTCCCACC TCCACCCGCG CTCTGCGGGG CCTCTGCCTG 1680 TGATGTCTCC GTACGTGTGG TGGTGGGTGA GCCCACCGAG GCCAGGGTGG T TCCGGGCCG 1740 GGGCATCTGC CTGGACCTCG CCATCCTGGA TAGTGCCTTC CTGCTGTCCC AGGTGGCCCC 1800 ATCCCTGTTT ATGGGCTCCA TTGTCCAGCT CAGCCAGTCT GTCACTGCCT ATATGGTGTC 1860 TGCCGCAGGC CTGGGTCTGG TCGCCATTTA CTTTGCTACA CAGGTAGTAT TTGACAAGAG 1920 CGACTTGGCC AAATACTCAG CGTAGAAAAC TTCCAGCACA TTGGGGTGGA GGGCCTGCCT 1980 CACTGGGTCC CAGCTCCCCG CTCCTGTTAG CCCCATGGGG CTGCCGGGCT GGCCGCCAGT 2040 TTCTGTTGCT GCCAAAGTAA TGTGGCTCTC TGCTGCCACC CTGTGCTGCT GAGGTGCGTA 2100 GCTGCACAGC TGGGGGCTGG GGCGTCCCTC TCCTCTCTCC CCAGTCTCTA GGGCTGCCTG 2160 ACTGGAGGCC TTCCAAGGGG GTTTCAGTCT GGACTTATAC AGGGAGGCCA GAAGGGCTCC 2220 ATGCACTGGA ATGCGGGGAC TCTGCAGGTG GATTACCCAG GCTCAGGGTT AACAGCTAGC 2280 CTCCTAGTTG AGACACACCT AGAGAAGGGT TTTTGGGAGC TGAATAAACT CAGTCACCTG 2340 GTTTCCCATC TCTAAGCCCC TTAACCTGCA GCTTCGTTTA ATGTAGCTCT TGCATGGGAG 2400 TTTCTAGGAT GAAACACTCC TCCATGGGAT TTGAACATAT GACTTATTTG TAGGGGAAGA 2460 GTCCTGAGGG GCAACACACA AGAACCAGGT CCCCTCAGCC CACAGCACTG TCTTTTTGCT 2520 GATCCACCCC CCTCTTACCT TTTATCAGGA TGTGGCCTGT TGGT CCTTCT GTTGCCATCA 2580 CAGAGACACA GGCATTTAAA TATTTAACTT ATTTATTTAA CAAAGTAGAA GGGAATCCAT 2640 TGCTAGCTTT TCTGTGTTGG TGTCTAATAT TTGGGTAGGG TGGGGGATCC CCAACAATCA 2700 GGTCCCCTGA GATAGCTGGT CATTGGGCTG ATCATTGCCA GAATCTTCTT CTCCTGGGGT 2760 CTGGCCCCCC AAAATGCCTA ACCCAGGACC TTGGAAATTC TACTCATCCC AAATGATAAT 2820 TCCAAATGCT GTTACCCAAG GTTAGGGTGT TGAAGGAAGG TAGAGGGTGG GGCTTCAGGT 2880 CTCAACGGCT TCCCTAACCA CCCCTCTTCT CTTGGCCCAG CCTGGTTCCC CCCACTTCCA 2940 CTCCCCTCTA CTCTCTCTAG GACTGGGCTG ATGAAGGCAC TGCCCAAAAT TTCCCCTACC 3000 CCCAACTTTC CCCTACCCCC AACTTTCCCC ACCAGCTCCA CAACCCTGTT TGGAGCTACT 3060 GCAGGACCAG AAGCACAAAG TGCGGTTTCC CAAGCCTTTG TCCATCTCAG CCCCCAGAGT 3120 ATATCTGTGC TTGGGGAATC TCACACAGAA ACTCAGGAGC ACCCCCTGCC TGAGCTAAGG 3180 GAGGTCTTAT CTCTCAGGGG GGGTTTAAGT GCCGTTTGCA ATAATGTCGT CTTATTTATT 3240 TAGCGGGGTG AATATTTTAT ACTGTAAGTG AGCAATCAGA GTATAATGTT TATGGTGACA 3300 AAATTAAAGG CTTTCTTATA TGTTTAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA 3360 AAAAAAAARA AAAAAAAAAA AAAAAAAAAA AAAAAAA TAA AAAAAAAAAA 3410 4. A diagnostic tool set comprising an oligonucleotide probe comprising at least about 1 of a DNA molecule having a sequence selected from the group consisting of sequence identification numbers: 10, 1 1 and 1 10 5 adjacent nucleotides; 52031-931015.DOC-5-This paper size applies to Chinese National Standard (CNS) A4 specifications (210 X 297 mm) 1228593 A8 B8 C8 D8 6. Application for patent scope Among which the sequence identification number: 10,11, no the sequences are shown below: SEQ ID Ν Ο: 1 0: CAGTCTATNT GGCCAGTGTG GCAGCTTTCC CTGTGGCTGC CGGTGCCACA TGCCTGTCCC 60 ACAGTGTGGC CGTGGTGACA GCTTCAGCCG CCCTCACCGG GTTCACCTTC TCAGCCCTGC 120 AGATCCTGCC CTACACACTG GCCTCCCTCT ACCACCGGGA GAAGCAGGTG TTCCTGCCCA 180 AATACCGAGG GGACACTGGA GGTGCTAGCA GTGAGGACAG CCTGATGACC AGCTTCCTGC 240 CAGGCCCTAA GCCTGGAGCT CCCTTCCCTA ATGGACACGT GGGTGCTGGA GGCAGTGGCC 300 TGCTCCCACC TCCACCCGCG CTCTGCGGGG CCTCTGCCTG TGATGTCTCC GTACGTGTGG 360 TGGTGGGTGA GCCCACCGAN GCCAGGGTGG TTCCGGGCCG GGGCATCTGC CTGGACCTCG 420 CCATCCTGGA TAGTGCTTCCCT CTGTG TTA TGGGCTCCAT 480 TGTCCAGCTC AGCCAGTCTG TCACTGCCTA TATGGTGTCT GCCGCAGGCC TGGGTCTGGT 540 CCCATTTACT TTGCTACACA GGTANTATTT GACAAGAACG ANTTGGCCAA ATACTCAGCG 600 TTAAAAAATT CCAGCAACAT TGGGGGTGGA AGGCCTGCCT CACTGGGTCC AACTCCCCGC 660 TCCTGTTAAC CCCATGGGGC TGCCGGCTTG GCCGCCAATT TCTGTTGCTG CCAAANTNAT 720 GTGGCTCTCT GCTGCCACCT GTTGCTGGCT GAAGTGCNTA CNGCNCANCT NGGGGGGTNG 780 GGNGTTCCC 789 SEQ ID Ν Ο: 1 1: CCCACCCTAC CCAAATATTA GACACCAACA CAGAAAAGCT AGCAATGGAT TCCCTTCTAC 60 TTTGTTAAAT AAATAAGTTA AATATTTAAA TGCCTGTGTC TCTGTGATGG CAACAGAAGG 120 ACCAACAGGC CACATCCTGA TAAAAGGTAA GAGGGGGGTG GATCAGCAAA AAGACAGTGC 180 TGTGGGCTGA GGGGACCTGG TTCTTGTGTG TTGCCCCTCA GGACTCTTCC CCTACAAATA 240 ACTTTCATAT GTTCAAATCC CATGGAGGAG TGTTTCATCC TAGAAACTCC CATGCAAGAG 300 CTACATTAAA CGAAGCTGCA GGTTAAGGGG CTTANAGATG GGAAACCAGG TGACTGAGTT 360 TATTCAGCTC CCAAAAACCC TTCTCTAGGT GTGTCTCAAC TAGGAGGCTA GCTGTTAACC 420 CTGAGCCTGG GTAATCCACC TGCAGAGTCC CCGCATTCCA GTGCATGGAA CCCTTCTGGC 480 CTCCCTGTAT AAGTCCAG AC TGAAACCCCC TTGGAAGGNC TCCAGTCAGG CAGCCCTANA 540 AACTGGGGAA AAAAGAAAAG GACGCCCCAN CCCCCAGCTG TGCANCTACG CACCTCAACA 600 GCACAGGGTG GCAGCAAAAA AACCACTTTA CTTTGGCACA AACAAAAACT NGGGGGGGCA 660 ACCCCGGCAC CCCNANGGGG GTTAACAGGA ANCNGGGNAA CNTGGAACCC AATTNAGGCA 720 GGCCCNCCAC CCCNAATNTT GCTGGGAAAT TTTTCCTCCC CTAAATTNTT TC 772 SEQ ID NO: 1 10: GGGAACCAGC CTGCACGCGC TGGCTCCGGG TGACAGCCGC GCGCCTCGGC CAGGATCTGA 60 GTGATGAGAC GTGTCCCCAC TGAGGTGCCC CACAGCAGCA GGTGTTGAGC ATGGGCTGAG 120 AAGCTGGACC GGCACCAAAG GGCTGGCAGA AATGGGCGCC TGGCTGATTC CTAGGCAGTT 180 GGCGGCAGCA AGGAGGAGAG GCCGCAGCTT CTGGAGCAGA GCCGAGACGA AGCAGTTCTG 240 GAGTGCCTGA ACGGCCCCCT GAGCCCTACC CGCCTGGCCC ACTATGGTCC AGAGGCTGTG 300 GGTGAGCCGC CTGCTGCGGC ACCGGAAAGC CCAGCTCTTG CTGGTCAACC TGCTAACCTT 360 TGGCCTGGAG GTGTGTTTGG CCGCAGGCAT CACCTATGTG CCGCCTCTGC TGCTGGAAGT 420 GGGGGTAGAG GAGAAGTTCA TGACCATGGT GCTGGGCATT GGTCCAGTGC TGGGCCTGGT 480 CTGTGTCCCG CTCCTAGGCT CAGCCAGTGA CCACTGGCGT GGACGCTATG GCCGCCGCCG 540 GCCCTTCATC TGGGC ACTGT CCTTGGGCAT CCTGCTGAGC CTCTTTCTCA TCCCAAGGGC 600 CGGCTGGCTA GCAGGGCTGC TGTGCCCGGA TCCCAGGCCC CTGGAGCTGG CACTGCTCAT 660 CCTGGGCGTG GGGCTGCTGG ACTTCTGTGG CCAGGTGTGC TTCACTCCAC TGGAGGCCCT 720 GCTCTCTGAC CTCTTCCGGG ACCCGGACCA CTGTCGCCAG GCCTACTCTG TCTATGCCTT 780 CATGATCAGT CTTGGGGGCT GCCTGGGCTA CCTCCTGCCT GCCATTGACT GGGACACCAG 840 TGCCCTGGCC CCCTACCTGG GCACCCAGGA GGAGTGCCTC TTTGGCCTGC TCACCCTCAT 900 CTTCCTCACC TGCGTAGCAG CCACACTGCT GGTGGCTGAG GAGGCAGCGC TGGGCCCCAC 960 CGAGCCAGCA GAAGGGCTGT CGGCCCCCTC CTTGTCGCCC CACTGCTGTC CATGCCGGGC 1020 CCGCTTGGCT TTCCGGAACC TGGGCGCCCT. GCTTCCCCGG CTGCACCAGC TGTGCTGCCG 1080 CATGCCCCGC ACCCTGCGCC GGCTCTTCGT GGCTGAGCTG TGCAGCTGGA TGGCACTCAT 1140 GACCTTCACG CTGTTTTACA CGGATTTCGT GGGCGAGGGG CTGTACCAGG GCGTGCCCAG 1200 AGCTGAGCCG GGCACCGAGG CCCGGAGACA CTATGATGAA GGCGTTCGGA TGGGCAGCCT 1260 GGGGCTGTTC CTGCAGTGCG CCATCTCCCT GGTCTTCTCT CTGGTCATGG ACCGGCTGGT 1320 GCAGCGATTC GGCACTCGAG CAGTCTATTT GGCCAGTGTG GCAGCTTTCC CTGTGGCTGC 1380 CGGTGCCACA TGC CTGTCCC ACAGTGTGGC CGTGGTGACA GCTTCAGCCG CCCTCACCGG 1440 GTTCACCTTC TCAGCCCTGC AGATCCTGCC CTACACACTG GCCTCCCTCT ACCACCGGGA 1500 GAAGCAGGTG TTCCTGCCCA AATACCGAGG GGACACTGGA GGTGCTAGCA GTGAGGACAG 1560 CCTGATGACC AGCTTCCTGC CAGGCCCTAA GCCTGGAGCT CCCTTCCCTA ATGGACACGT 1620 GGGTGCTGGA GGCAGTGGCC TGCTCCCACC TCCACCCGCG CTCTGCGGGG CCTCTGCCTG 1680 TGATGTCTCC GTACGTGTGG TGGTGGGTGA GCCCACCGAG GCCAGGGTGG TTCCGGGCCG 1740 GGGCATCTGC CTGGACCTCG CCATCCTGGA TAGTGCCTTC CTGCTGTCCC AGGTGGCCCC '1800 ATCCCTGTTT ATGGGCTCCA TTGTCCAGCT CAGCCAGTCT GTCACTGCCT ATATGGTGTC 1860 TGCCGCAGGC CTGGGTCTGG TCGCCATTTA CTTTGCTACA CAGGTAGTAT TTGACAAGAG 1920 CGACTTGGCC AAATACTCAG CGTAGAAAAC Standard XXCC-AWG-CCCGC-CCCGC-CCCGC-CCCGC-CCCGC-CCCGC-CCC-CCC-CCC-CGC C8 D8 VI. Patent application scope 2040 2100 2160 2220 2280 2340 2400 2460 2520 2580 2640 2700 2760 2820 2880 2940 3000 3060 3120 3180 3240 3300 3360 3410 CACTGGGTCC CAGCTCCCCG CTCC TGTTAG CCCCATGGGG CTGCCGGGCT GGCCGCCAGT TTCTGTTGCT GCCAAAGTAA TGTGGCTCTC TGCTGCCACC CTGTGCTGCT GAGGTGCGTA GCTGCACAGC TGGGGGCTGG GGCGTCCCTC TCCTCTCTCC CCAGTCTCTA GGGCTGCCTG ACTGGAGGCC TTCCAAGGGG GTTTCAGTCT GGACTTATAC AGGGAGGCCA GAAGGGCTCC ATGCACTGGA ATGCGGGGAC TCTGCAGGTG GATTACCCAG GCTCAGGGTT AACAGCTAGC CTCCTAGTTG AGACACACCT AGAGAAGGGT TTTTGGGAGC TGAATAAACT CAGTCACCTG GTTTCCCATC TCTAAGCCCC TTAACCTGCA GCTTCGTTTA ATGTAGCTCT TGCATGGGAG TTTCTAGGAT GAAACACTCC TCCATGGGAT TTGAACATAT GACTTATTTG TAGGGGAAGA GTCCTGAGGG GCAACACACA AGAACCAGGT CCCCTCAGCC CACAGCACTG TCTTTTTGCT GATCCACCCC CCTCTTACCT TTTATCAGGA TGTGGCCTGT TGGTCCTTCT GTTGCCATCA CAGAGACACA GGCATTTAAA TATTTAACTT ATTTATTTAA CAAAGTAGAA GGGAATCCAT TGCTAGCTTT TCTGTGTTGG TGTCTAATAT TTGGGTAGGG TGGGGGATCC CCAACAATCA GGTCCCCTGA GATAGCTGGT CATTGGGCTG ATCATTGCCA GAATCTTCTT CTCCTGGGGT CTGGCCCCCC AAAATGCCTA ACCCAGGACC TTGGAAATTC TACTCATCCC AAATGATAAT TCCAAATGCT GTTACCCAAG GTTAGGGTGT TGAAGGAAGG TAGAGGGTGG GGCTTCAGGT CTCAACGGCT TCCCTAACCA CCCCTCTTCT CTT .GGCCCAG CCTGGTTCCC CCCACTTCCA CTCCCCTCTA CTCTCTCTAG GACTGGGCTG ATGAAGGCAC TGCCCAAAAT TTCCCCTACC CCCAACTTTC CCCTACCCCC AACTTT'CCCC ACCAGCTCCA CAACCCTGTT TGGAGCTACT GCAGGACCAG AAGCACAAAG TGCGGTT.TCC CAAGCCTTTG TCCATCTCAG CCCCCAGAGT ATATCTGTGC TTGGGGAATC TCACACAGAA ACTCAGGAGC ACCCCCTGCC TGAGCTAAGG GAGGTCTTAT CTCTCAGGGG GGGTTTAAGT GCCGTTTGCA ATAATGTCGT CTTATTTATT TAGCGGGGTG AATATTTTAT ACTGTAAGTG AGCAATCAGA GTATAATGTT TATGGTGACA AAATTAAAGG CTTTCTTATA TGTTTAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAARA AAAAAAAAAA AAAAAAAAAA AAAAAAATAA AAAAAAAAAA 52031-931015.DOC This paper size applies to China National Standard (CNS) A4 specifications (210 X 297 mm)