TW589337B - The self-supporting apertured sheets, the method of manufacture of the same and the wound dressings comprising the same - Google Patents

Abstract

A self-supporting apertured sheet consisting essentially of a water-swellable hydrogel composition, wherein the area of the apertures is up to about 50% of the area of the sheet before swelling. Also provided are wound dressings comprising such sheets. Also provided is a method of making such sheets comprising the steps of: providing an apertured substrate sheet; coating an aqueous hydrogel precursor onto the apertured substrate; curing the aqueous hydrogel precursor on the substrate to form an apertured hydrogel layer on the substrate sheet; and separating the apertured hydrogel layer from the substrate sheet.

Description

A7 A7 5 11 Printed by Shelley Consumer Cooperatives, Bureau of Intellectual Property, Ministry of Economic Affairs. 2 V. Description of the Invention (/) I --- The present invention relates to pore-swelling sheet materials and wound dressings including such sheet materials . It is known that maintaining a slightly moist wound environment can promote wound healing, especially wounds that are hot per month, such as ulcers, but also want to avoid excessive moisture on the wound or the fluid beach of the wound exudate, because the wound The exudate can cause skin and other distress to the skin around the wound. In addition, wound exudate can leak from the wound site and contaminate clothing or bedding. In fact, 'it is not easy to maintain the desired humidity at the wound site, because the rate of wound fluid production varies with each wound, and the same-the wound will change over time, so different dressings must often be changed and used differently. EP-A-0123456 describes the use of continuous polymer films for surgical dressings. Beans are produced from materials that have a higher moisture vapor permeability than wet films. EP A-087522 describes that a wound dressing includes a non-water-swellable, water-impermeable porous sheet with a cutting crack, wherein the slab sheet is laminated to a swelled foamed plastic layer. Absorbing the wound fluid causes the foamed plastic layer to swell, which causes deformation to open the cracks in the porous sheet, thereby increasing the liquid permeability of the porous sheet. EP-A-OM (85) describes that a wound dressing has a porous sheet obtained from a layer of water-swelling material to a less water-swelling layer, which has cut slits. In use, 'the difference in the degree of swelling of the porous plate and the underlying layer promotes the opening of cracks in the gap plate', so the permeability of the porous plate to the wound fluid can be increased. US-A-5352508 describes a porous matrix coated with hydrogel material (Please read the precautions on the back before filling this page}

91 · 3. 2,000 589337 A7 B7 V. Description of the invention (and) 10 15 20 Woven cloth for wound dressing. It has been found that some porous, self-supporting hydrogel sheets are swelled in water to obtain swellable sheets, which have higher liquid permeability than unexpanded sheets. Increased average area of pores. Therefore, the present invention provides a self-supporting porous plate, which mainly includes a hydrogel composition of a watercraft, in which the pores occupy less than 50% of the area of the front panel of the foam. Typically, the pores occupy from about 0.1% to about 50% of the area of the front panel of the blister (preferably the area of the panel facing the wound), and more typically, from about 1% to about 30% of the blister. The area of the panel before swelling is about 10% to about 25%. For the better, about 10% to about 20% of the blistering front panel area is most preferred. Porous hydrogel plates hold micro-wound wounds for a longer period of time 'and cover a wide range of wound exudation rates. #When the exudation rate is high, it causes the pore plate to expand, increasing its pore size, and thus increasing the liquid permeability: the plate can therefore absorb the wound fluid to prevent the wound from containing excessive moisture without removing it. When the hydrogel or the rate of wound exudate production in the pores of the hydrogel decreases, the hydrogel sheet will shrink: promote: the permeability of the liquid will decrease, which will help the wound surface maintain the wound fluid. In addition, the hydrogel absorbs water vapor 'and can be used as a wetting agent to keep the slightly wet wound contact surface. In some instances, the pore area is increased by at least about 25%, for example, by swelling the sheet to 25%. (: 60 minutes in water, it can increase at least about 50%. Typically, the plate has about 1 to 30 pores per square centimeter, for example: about 4 to about 15 pores per square centimeter or per square centimeter. The centimeter has' 4 paper standards applicable to Chinese national standards (CNS> A4 specification 91. 1. II — — — — — — — — — — — II (Please read the notes on the back before filling this page) Wisdom of the Ministry of Economic Affairs Printed by the Shellfish Consumer Cooperative of the Property Bureau 589337 A7 I-- ~ ------_____ V. Description of the invention (3) About 5 to about 10 pores. In some examples, the pores are evenly distributed on the surface of the panel It is better to use a regular pattern. The one with smaller pores is better, because when the hydrogel sheet swells, it will cause the liquid permeability to increase at the maximum rate, such as the average area of 5 pores per pore. It may be about 0.00 to about 10 square millimeters, preferably about (U to about 4 square millimeters, and most preferably about 1 square millimeter to about 2 square millimeters.… The pores may have any suitable shape as long as When the hydrogel is swelled, it can increase the pore size and increase the liquid permeability. Yes, in some examples, the ratio of the maximum length to the maximum width of the pores before inflation is about 1 to about 10 10 ′, preferably about 1 to about 3, and most preferably about 1 to about 1.5. The shape of the pores includes round, oval, or regular polygons. The cross-sectional area of the pores can be fixed through the thickness of the hydrogel sheet (tubular). In the form of an oblique truncated cone, this type of pores makes it easier for water to flow through the plate from one direction than through the plate in the opposite direction. Preferably, such pores have a bottom opening size (pore plate The maximum opening size at the top is G.1 mm to 3 mm, and the opening size at the apex (as far as the top of the pore plate) is 0.05 to 2 mm. The best pore has a bottom defined as such The opening size is 0.5 mm to 2 mm, and the apex 20 opening size is 0. 1 to 1.0 mm. The pores are at an angle of 10 to 60 degrees with a gradually decreasing average angle (measured from a plane perpendicular to the pore plate). Pore hydrogel sheets are available Line support, i.e., the aperture plate without any reinforcing or supporting sheet, a fabric, or a laminate web or an object embedded therein.

-Ordered! : -------- Xiang Tai (Please read the precautions on the back of JH before filling this page)

This paper size applies the Chinese National Standard (CNS) A4 specification (210 X 297 mm) 91. 3. 2,000 Printed by S Industrial Consumer Cooperative, Intellectual Property Bureau, Ministry of Economic Affairs 589337

V. Description of the invention (+) The porous hydrogel sheet generally mainly includes a hydrogel composition as described below. Of course, the self-supporting performance of the plate means that the hydrogel composition has a minimum intrinsic strength, and the preferred hydrogel composition (according to astm4i2, is on a continuous elongated sheet (2 · 5mm width) (Measurement) has a breaking force of 0.5 5 to 10 Newton, and the best is 1 to 5 Newton. The thickness of the porous plate (according to ASTM D374_79) is preferably about 0.2 to about 4 mm, and most preferably about 0.4 to 2 mm. The dry basis weight of the hydrogel layer is preferably about 10 to about 1,000 g / m 2, more preferably about 20 to about 200 g / m 2, and about 40 to about 10 g.丨 ⑼g / m² is the best. "Blister hydrogel composition, the term refers to a composition that absorbs water at physiological temperature and pH conditions, and forms a gel with water. Such a composition includes medically acceptable macromolecules Material, which has the ability to swell, and can absorb wound fluid while maintaining a solid overall structure. Generally, the hydrogel composition is substantially insoluble in water under physiological conditions, so the hydrogel will not be washed away by the wound fluid. Hydrogel can include a biopolymer, that is, it can be produced from a polymer that exists in nature, such as collagen, gelatin, or algin. Hydrogel can be bioabsorbable, that is, it can be slowly in its body. Re-absorption. 20 Typically, the porous sheet according to the present invention is immersed in water at 25 ° C for 60 minutes, and then absorbs at least about 10 weight / weight 1 / 〇 of water based on the weight of the sheet before immersion. Water of at least about 25 wt / wt% is preferred, water of at least about 50 wt / wt% is more preferred, and water of at least about 100 wt / wt% is most preferred. (Please read the back first (Notes to fill out this page)

This paper size applies Chinese National Standard (CNS) A4 (210 X 297 mm) 91. 3. 2,000 Printed by Shelley Consumer Cooperative of Intellectual Property Bureau of the Ministry of Economic Affairs 589337 A7 V. Description of Invention (g) Not > Gu Yushui Examples of gels include cross-linked polyacrylate gels, such as those described in EP-A-0676457, calcarein, cross-linked glucosamine anaerobic acid gels, alginate derivatives, such as : Propylene glycol algal gel, gel, and gel, in which the generation of hydrogenated polymers is derived from: vinyl alcohols, vinyl 5 esters, vinyl ethers and carboxy vinyl monomers, methacrylic acid, acrylic acid Amine, N-vinylpyrrolidone, fluorenylamidopropanesulfonic acid, PLURONIC (registered trademark) (block polyethylene glycol, block polypropylene glycol) polystyrene ... maleic acid, N, N-difluorenyl Acrylamide, diacetone acrylamide, acrylmorpholine, and mixtures thereof, suitable hydrogels are also described in 10 US-A-5352508. A preferred hydrogel composition includes a macromolecular material selected from the group consisting of: polyurethane gel, biopolymer gel, methyl cellulose gel, hydroxyethyl cellulose gel, hydroxypropyl Methylcellulose, polyacrylates, and mixtures thereof. Suitable biopolymer gels include: algin, pectin, gelatine 15, galactomannan, such as: Gua and flavonic acid, polychitosan, gelatin , Glass sugar vinegar, and its mixture, some of these biopolymer materials can also promote wound healing. The gel is preferably chemically or physically cross-linked, and chemical cross-linking may be pingvalent or ionic. ^ 20 Based on the weight of the sheet before inflation, the porous sheet can include at least 50 weight percent / reset% of gel-forming macromolecular material, and preferably at least about 75 weight / weight%. On the same basis, the hydraulic kick material may further include about 5 to about 50% by weight, and preferably 15 to 40% by weight of one or more moisture retention agents, such as glycerin. Under the same standard, hydraulic aggregates can be additionally included to this paper size. Applicable to China National Standard (CNS) A4 specification (210 X 297 male " i 91 · 3. 2,000 (Please read the precautions on the back before filling this page) ) I ^ --- I ---- ^ --------- Printed by Shellfish Consumer Cooperative of Intellectual Property Bureau of the Ministry of Economic Affairs 589337 A7 B7_ V. Description of the invention (G) 30% / wt% more, It is preferably at most about 15% by weight / weight%. Water 0 is based on the weight of the composition before inflation. The hydrogel composition may further include at most about 10% by weight / weight%, at 0.1 to 5% by weight / weight%. Medical products that are better than 5. Suitable medical products include preservatives, such as silver sulfadazine, chlorhexidine, triclosan, or povidone moth, Analgesics, steroids, antibiotics, auxins, or mixtures thereof. The porous plate according to the invention is preferably substantially sterile. The porous plate according to the invention is adhesive in some examples and in some 10 examples. The hydrogel composition of the plate itself has adhesiveness. In other examples, the medical An acceptable pressure-sensitive adhesive is applied to the surface of the porous sheet. In some examples, the hydrogel layer includes a cross-linked polyacrylate hydrogel material, such as: EP-A-0676457, The materials described in WO 00/0763 8 15 or WO 00/45866 are incorporated herein by reference in their entirety. The present invention further provides a wound dressing comprising a porous sheet according to the present invention. Preferred wound dressings other than the porous sheet It includes an absorbent layer and / or a support layer. In this case, it is better for the porous sheet to be the top 20 layers facing the wound. More preferably, the dressing additionally includes a support on the back of the porous sheet. This support layer is better to provide a barrier to the passage of microorganisms through the dressing, and it is better to prevent wound fluid from flowing out of the dressing. The support layer extends at least on one side of the absorbent layer and is provided immediately adjacent to the aforementioned one. Coating Adhesive '8 This paper size is applicable to Chinese National Standard (CNS) A4 (210 X 297 mm) 91. 3. 2,000 (Please read the precautions on the back before filling this page) · · n ϋ n an nn ^ OJ · nn I n i n- Printed by the staff of the Intellectual Property Bureau of the Ministry of Economic Affairs and printed by the cooperative 589337 A7 B7 V. The edge of invention description (7) to adhere the dressing to a surface, such as: to the skin of the patient next to the wound being treated. Apply adhesive The edges can extend to the four sides of the absorbent layer, so that the dressing is a so-called island dressing, however, it is not necessary to have any adhesive-coated edges. 5 The support layer is preferably substantially impermeable to liquid, the support layer It is better to use semi-permeable, that is, the support layer is permeable to water vapor, but it is not permeable to water or wound exudate, and the support layer is also to be permeable to microorganisms. Suitable continuous and consistent support layer, at 37.5 ° C and 100% to 10% relative humidity, a single support layer with 300 to 5000 g / m² / 24 hour water vapor transmission rate (MVTR) is The best is 500 to 2000 g / m² / 24 hours. The thickness of the support layer is preferably in the range of 10 to 1000 microns, and most preferably 100 to 500 microns. According to the present invention, the dressing as a whole has a lower MVTR than the individual support layer, because the porous sheet partially hinders water vapor from passing through the dressing, and the 15 MVTR of the dressing (measured across the island of the dressing) is 20% to MVTR of the separate support layer. 80% is better, 20% to 60% is better, and about 40% is best. It has been found that this water vapor penetration rate allows the wound under the dressing to heal in a slightly moist condition without macerating the skin around the wound. Polymers suitable for use in the production of support plates include: polyurethanes and 20 polyalkoxyalkyl acrylates and methacrylates, as disclosed in GB-A-1280631. The support layer consists of high-density end-capped polyurethane foam, mainly closed cells. A continuous layer is preferred. A suitable support sheet material is a commercially available polyurethane with registered trademark ESTANE 5714F. Ester film 0 This paper size is applicable to China National Standard (CNS) A4 (210 X 297 cm) 91. 3. 2,000 (Please read the precautions on the back before filling this page)

A7 Printed by the Intellectual Property Bureau of the Ministry of Economic Affairs, the Beiya Consumer Cooperative. V. Invention Description (y) The adhesive layer (existing on the right) should have water vapor permeability and / or be patterned to form a channel through which the π crosses. It has a pressure-sensitive adhesive layer with continuous water vapor penetration 14, which is preferred for conventional island-shaped wound dressings. For example:-a pressure-sensitive adhesive, whose base f is acrylic copolymer, polyethylene based _ With polyurethane, as described in GB_A] 280631. The reference weight of the anchoring layer is preferably from 20 to 250 g / m 2, most preferably from 50 to 150 g / m 2, and a pressure-sensitive adhesive based on polyurethane is preferred. . Preferably, the adhesive layer extends outward from the absorbing layer, and forms an edge for applying an adhesive on the periphery of the support layer, and surrounds the adhesive layer such as a conventional island dressing. The area of the selective absorption layer is typically in the range of from ^ 2 to ^ 2, and preferably from 4 to 100 cm2. The selective absorbent layer may be any layer conventionally used in wound healing techniques to absorb wound fluid, serum, or blood, including two gauze, non-woven fabrics, strong absorbents, hydrogels, and mixtures thereof, preferably the absorbent layer includes a An absorbent foamed plastic layer, such as an open-celled hydrophilic polyurethane foam made in accordance with EP_Winter 541391, is hereby incorporated by reference in its entirety. In other examples, the absorbent layer may be a non-woven mesh, such as two carded meshes with hook and loop woven fabrics. The reference weight of the absorbing layer can be in the range of 50 to g / m2, such as 100 to 400 g / m2. The uncompressed thickness of the absorbent layer can range from 0.5 mm to 10 mm, such as: 丨 mm to 4 mm. The natural (uncompressed) liquid absorption measured at 25 ° C in normal saline can range from 5 to 30 g / g. The wound dressing according to the present invention is sterile and packaged in a way that cannot be penetrated by microorganisms 5 10 15 20 91. 3. 2,000 n 1 nnn 1 1 n 1 n It -II · n 1 · (Please read the precautions on the back before filling (This page) * φ-

589337 Printed by the Anti-Poverty Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs A7 B7 V. Description of the invention (1) It is better to put it in a transparent container. In another aspect, the present invention provides a method for manufacturing a porous sheet, including the following steps: providing a sheet of a porous matrix; 5 coating a water-soluble hydrogel precursor on the porous matrix; The mature hydrogel precursor is matured to generate a porous hydrogel layer on the matrix plate; and the hydrogel layer to be crosslinked is separated from the matrix plate. The preferred substrate sheet is a perforated thermoplastic film, such as: PTFE film 10 or t-acetylene film or ethylene vinyl acetate (EVA) film. Vacuum-perforated films are preferred, for example: the pores described in GB-Ai 526778 Thinning film. In other examples, the substrate sheet may be a perforated metal or plastic sheet, or a mesh of metal or thermoplastic threads. In some examples, the substrate sheet may be coated with a release coating, such as a silicone release coating, to assist the release of the porous sheet product from the substrate. A hydrogel precursor is a pre-gel composition that can form a water-insoluble hydrogel after cooling, polymerization, or cross-linking. Examples include: water-soluble sodium alginate, which can be cemented with calcium salts. Another example is ancient gum, which can be gelled by borate. In other examples, the pregel is a composition that can be cured. 20 It includes one or more monomers and typically one or more crosslinking agents and / Or polymerization initiator. The preferred monomers are acrylates, such as: methamphetamine 2-meryl ethyl ester, propylamine, such as: n, N-dimethylacrylamide, and the same is preferably 2-propane Mixture of dilute amine-2-methylpropionate salts or ci to C5 δ purpose 'and salts of acrylic acid (3-propane) g or ci to C5' 11 Size of this paper Applicable to China National Standard (CNS) A4 (210 X 297 mm) 91 · 3. 2.000 (Please read the precautions on the back before filling this page)

589337 A7 _ B7 V. Description of the invention () Alkyl esters. A suitable cross-linking agent is polyethylene glycol diacrylate, and a suitable cross-linking initiator is a conventional peroxide initiator. (Please read the notes on the back before filling this page.) A suitable pregel material is a UV-curable polyacrylate pregel, as described in WO 00/65143, which is incorporated herein by reference in its entirety. 5 It is preferred to adjust the viscosity of the pregel to provide the desired thickness of the pregel layer on the substrate. Pregels can be applied to the surface of the substrate by spray or slit coating or extrusion, or using a medical blade. Pores can be generated in the pre-gel coating layer, for example: a gas pressure differential can be applied across the coated substrate to blow holes 10 gaps in the coating layer. This general form of method is described in, for example, WO 93 / 19709, or a pore hydrogel can also be coated on the pore matrix, as described in 5000/65143, which is incorporated herein by reference in its entirety. The porous hydrogel sheet is preferably separated from the matrix by peeling. In another aspect, the present invention provides a method for treating a wound, which comprises the steps of applying a dressing according to the present invention to a wound surface, and contacting the wound through a porous hydrogel sheet. Specific examples of the present invention will now be described by way of example. Example 1 Printed by Bei Gong Xiao F Cooperative of Intellectual Property Bureau of the Ministry of Economic Affairs 2 A porous hydrogel sheet according to the present invention was prepared according to the following method. A: A substrate sheet comprising a polyethylene film, each of which has 10 holes per square A knife, spoon, and each hole is substantially conical as described above, with a maximum aperture of approximately ^ Mm, the area of the opening is 16/0 ′ of the total area of the front surface, and the thickness is about 43 microns, and the thickness of the embossing is about 0.5 mm. This paper is suitable for financial standards (CNS) A4 297 mm) 2.000 589337 A7 Printed by Shelley Consumer Cooperative of Intellectual Property Bureau of the Ministry of Economic Affairs 5. Description of the invention (//) Such perforated sheet can be obtained from Tredegar Film Products Company , Richmond, Virginia, registered trademark is VISPORE. The matrix plate is a smooth, perforated upper surface, and then a spray-coated layer of hydrogenated polymer pregel 6 is applied to the surface. The pregel includes bovine gel in about 25 ° C water. The gel concentration is adjusted in the range of 5 to 20% by weight / weight% so as to provide a desired viscosity to obtain a uniform adhesive layer which is intended to be used on the substrate as much as possible. A suction is then applied to the back of the substrate, and the pre-gel layer is vacuum perforated to mark holes in the substrate. Then the gel was cross-linked by the treatment of glutarine or Jiajun. After the cross-linked gel sheet was dried at 4 ° C, it was peeled from the matrix sheet. The obtained hydrogel sheet had a drying standard It weighs 100 g / m² and includes a gel of bovine cross-linked with glutaraldehyde or formaldehyde. This plate has about 10 holes per square centimeter, and each hole has a maximum pore size of about 0.8 In the range of 1.2 mm, the opening area is about 5 to 10% of the total area of the porous plate. After soaking in water for 25 hours at 25 ° C, the gel has swelled but has not bathed, and its pores can be seen to increase. Therefore, the liquid permeability of the plate is increased. The plate can be directly used in packaging, or can be made into a multi-layer wound dressing according to the present invention, which can be sterilized using gamma rays. When using, remove the dressing from the package and remove The porous hydrogel sheet is applied to the wound, and the hydrogel is brought into contact with the wound to provide a sterile and absorbent dressing. The hydrogel sheet has so far unexpectedly interacted in a comparable section of J. For a wide range of Range of wounds provide slightly moist but do not wet the wound Nearby '510152013 (Please Note the back surface of the page and then fill Mtt)

91. 3. 2,000 589337 A7 printed by Shellfish Anti-Poverty Cooperative of Intellectual Property Bureau of the Ministry of Economic Affairs ----------- B7 V. Description of the Invention (丨 1) Example 2 Produced from polyvinylpyrrolidone (PVP) gel The pore plate according to the present invention is prepared by the following pre-gel formula: PVP 20% 5 water 79.16% Acetone 0.25% Ethyl secondary 0.03% Propyl secondary 0.05% Butyl secondary 0.01% 10 2-benzene The resulting gel solution was then extruded through a slot mold onto a substrate of the same type as in Example 1, and moved at a speed of 5 meters / minute, with a coating weight of 1,000 grams / square. Remove the meter and apply 15 suction as described in Example i for pregel perforation. After that, the pregel was cured by passing through an oven at 60 ° C, and the obtained cured hydrogel layer was dried at 40 ° C and peeled from the substrate. Example 3 20 A PTFE mold was prepared. The height of the protrusions was 3 mm, the diameter of the bottom was 2 mm, and the diameter of the top of the cone was 1 mm. Fill the mold with a polyacrylate monomer solution prepared in the following way: 80 ml of 2-propenylamine methylpropanesulfonic acid made from 50 wt / vol%, 20 ml of water, 5 ml of potassium gaseous (5 weight / Volume%), this paper size applies Chinese National Standard (CNS) A4 specification (210 X 297 male «) (Please read the precautions on the back before filling this page)

91. 3. 2,000 589337 A7 V. Description of the invention (Λ3) 0.15 ml of a solution of 1g 2G & PEG4GG and 6 parts of 1xylcyclohexylphenylfluorene. The monomer solution was polymerized by exposure to ultraviolet light, and the polymerized gel was peeled from the plastic core to provide a self-supporting porous gel. 5 Descriptive examples are provided for illustration only, and many other examples within the scope of the accompanying patent application should be obvious to the specialized reader. (Please fill in the notes on the back of Mtt before filling out this page.) Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs. This paper size applies to China National Standard (CNS) A4 (210 X 297 cm) 91. 3. 2,000

Claims (1)

ROC Patent Appln. No. 91116522 No. 91116522 Amended Claims in Chinese-Enci. (T) 5-Amended Claims in Chinese-Enci. (T) 5 (Submitted on August) ιζ 2003) 1. A self-supporting pore plate mainly includes a hydrogel composition with water swell, wherein the pore area is 0.1 / 10 of the area before the plate swell. 10 to 50%. 2. The pore plate according to item 1 of the scope of patent application, which has 1 to 30 pores per square centimeter. 3. The pore plate according to item 1 or 2 of the scope of patent application, wherein the average area of each pore is from 0.001 to 4 square millimeters. 15 4. The porous sheet according to item 1 or 2 of the scope of patent application, wherein the pores have a length to width ratio from 1 to 10 before inflation. 5. The porous sheet according to item 1 of the scope of patent application, wherein the pore area is increased by at least 50% by immersing the sheet in water at 25 ° C for 60 minutes. 20 6. The porous sheet according to item 1 or 5 of the scope of the patent application, in which the swelling hydrogel composition is printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Bubbling Economy, and the slender sheet with a width of 2.5 cm has a tensile strength of 2 to 5 Newton. 7. The pore plate according to item 1 or 5 of the scope of patent application, wherein the pores gradually become smaller from the front surface to the rear surface of the plate. -25 8 · According to the pore plate of item 1 or 5 of the scope of the patent application, where the plate is immersed in water at 25 ° C for 60 minutes, based on the weight of the plate before immersion, the plate absorbs 50 weight / weight% to 1 〇〇wt / wt% water. -16-This paper size applies Chinese National Standard (CNS) A4 specification (210x297 mm) 91330B-connected 589337 A8 B8 C8 _D8_ VI. Application scope of patent 9. According to the application of the patent application scope 1 or 5 of the porous sheet, The plates have a dry basis weight from 10 to 1000 g / m². 10. The porous sheet according to item 1 or 5 of the scope of the patent application, wherein the sheet has a thickness from about 0.2 to about 45 meters as measured in accordance with ASTM D374-79. 11. The porous plate according to item 1 or 5 of the scope of patent application, wherein the plate material includes a hydrogel selected from the group consisting of polyurethane gel, gelatin, pectin, algin, and glucosamine Sugar gels, glaucose carbonate gels, guar gum, xanthan gum, gels derived from starch derivatives, 10 carboxymethyl cellulose gel, hydroxyethyl cellulose gel, hydroxypropyl methyl ester Cellulose, polyethylene oxide, and mixtures thereof. 12. The porous sheet according to item 1 or 5 of the scope of patent application, wherein the hydrogel layer includes a hydrogel selected from gels formed by polymerization or copolymerization of the following: vinyl alcohols, vinyl esters, Vinyl ethers and carboxy 15-based vinyl monomers, meth (acrylic) acid, vinylamine monomers, printed vinyl monomers, hydroxy vinyl monomers, employee cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs Cationic vinyl monomers include amines or quaternary groups, ionic acrylamide derivatives, N-alkyl acrylamide, esters of acrylates, ester derivatives of ionic acrylates, N-vinyl Pyrrolidone, fluorenilinopropylpropanesulfonic acid, maleic acid, N, N-difluorenylacrylamide, diacetoneacrylamide or acrylamide morpholine. 13. The porous sheet according to item 1 or 5 of the application, wherein the hydrogel is chemically or physically crosslinked. 14. A wound dressing comprising a paper according to the scope of patent application Nos. 1 to -17-this paper size applies Chinese National Standard (CNS) A4 specifications (210 X 297 mm) 8 8 8 8 AB c D Intellectual Property Bureau of the Ministry of Economic Affairs Printed by the Employee Consumer Cooperative 589337 VI. Porous sheet of any of the 13 patent applications. 15. The wound dressing according to item 14 of the application, further comprising an absorbent layer in contact with the back surface of the apertured sheet. 16. The wound dressing according to claim 14 or 15, wherein the absorbent layer includes a hydrophilic foamed plastic layer. 17. The wound dressing according to item 14 or 15 of the patent application scope, wherein the dressing further comprises a support layer covering the porous sheet. 18. The wound dressing according to claim 17 in which the support layer is substantially liquid permeable. 10 19. The wound dressing according to item 14 or 15 of the scope of patent application, further comprising an adhesive layer on the surface of the support layer and facing the porous sheet. 20. The porous sheet according to item 5 of the patent application, wherein the support layer extends at least beyond one edge of the porous sheet to provide an edge for applying an adhesive immediately adjacent to the aforementioned side, thereby adhering the dressing to a surface. 15 21. The wound dressing according to item 14 or 15 of the scope of patent application, which is sterile and packaged in a container impermeable to microorganisms. 22. —A method for manufacturing a porous sheet according to any one of claims 1 to 13 of the scope of patent application, comprising the steps of: providing a sheet of a porous matrix; 20 applying a water-soluble hydrogel precursor to the porous sheet Base H; ripening the water-soluble hydrogel precursor on the substrate to form a porous hydrogel layer on the substrate plate; and separating the porous hydrogel layer from the substrate plate. 23. The method according to item 22 of the scope of patent application, in which water-soluble hydrogel -18-This paper size is applicable to China National Standard (CNS) A4 (210x297 mm) 589337 8 8 8 8 A B c D Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 6. Scope of patent application The coating of the precursor is perforated by applying a gas pressure difference across the coated substrate. -19-This paper size applies to China National Standard (CNS) A4 (210 X 297 mm)