TW584552B - Radiofrequency thermal balloon catheter - Google Patents

Abstract

A radiofrequency thermal balloon catheter makes it possible to heat uniformly the tissues in contact with the balloon and to achieve thermotherapy such as ablation or hyperthermia safely and properly for a diseased part. A radiofrequency thermal balloon catheter includes a catheter (4) consisting of an outer shaft (2) and an inner shaft (3) extended through the outer shaft so as to be slidable relative to the outer shaft, an inflatable balloon (6) capable of being inflated so as to be in contact with a target lesion (18) and equipped between respective front end parts of the outer and the inner shaft, a radiofrequency electrode (8) extended in a wall of the balloon or inside the balloon to be used for radiofrequency energy supply in combination with a counter electrode (53), the counter electrode being disposed at a predetermined position, for example, inside the balloon, in the wall of the balloon, in the position neighboring the balloon or on the patient's body surface, a lead wire (10) electrically connected to the radiofrequency electrode, a temperature sensor (12) capable of sensing temperature of a liquid contained in the balloon, and a temperature distribution uniformizing means such as a revolving structure (14) for uniformizing temperature distribution in the liquid contained in the balloon.

Description

584552 发明 Description of the invention (The description of the invention should be made clear: the technical field to which the invention belongs, the prior art, the content, the embodiments, and the illustration of the drawings)

The technical field to which C invention belongs; the field of J invention The present invention relates to a radio-frequency hot-air balloon catheter (RTBC). More specifically, 5 'is a radio-frequency hot-air balloon catheter for the treatment of cardiovascular diseases. t Prior Art 3

Background of the invention

A treatment method using an inflatable balloon and supplying radio frequency energy to the electrodes to heat 10 tissues in contact with the balloon to treat a radio frequency electric field is disclosed in Japanese Patent Nos. 2538375, 2510428, and 2574119 as approved by the applicant of the present invention . The tissue in contact with the balloon must be heated uniformly or homogeneously to achieve the desired treatment. However, the electrode lines forming the electrodes cannot be uniformly arranged in the balloon. If the wire of the electrode is arranged irregularly, the liquid contained in the balloon is heated with irregularity or different texture. The local temperature difference of the liquid contained in the balloon also increases due to convection and the temperature of the upper part of the balloon becomes higher. As such, the distribution within the balloon will inevitably be irregular or heterogeneous. Therefore, the tissue contacted by the balloon cannot be heated uniformly. [Summary of the Invention] SUMMARY OF THE INVENTION Accordingly, the object of the present invention is to solve the above-mentioned conventional problems, that is, to provide a radio-frequency hot-air balloon catheter, which can evenly heat the tissues in contact with the balloon to achieve thermotherapy, If it falls off safely or is overheated, it is suitable for a diseased area when it is suitable for 5 5 bumps. According to the present invention, a radio-frequency hot-air balloon catheter includes a catheter composed of an outer rod and an outer tube, the inner rod extending through the outer rod, sliding relative to the outer rod, and an inflation balloon, Inflatable 目 目 —— The relevant part of the damage department is placed in the _ material ^ of the material pole. S — RF electrode 'is used to cooperate with the-counter electrode to supply RF energy. Extension = the wall of the balloon or the balloon. Inside, the counter electrode is arranged at a predetermined position, a lead wire is electrically connected to the radio frequency electrode; a temperature sensor that can sense the temperature of the liquid contained in the balloon; and a uniform temperature distribution, It is used to uniformize the temperature distribution of the liquid contained in the balloon. The temperature distribution uniformization device uniformizes the temperature of the liquid contained in the balloon to prevent the liquid contained in the balloon from convection. Or the like produces an irregular temperature distribution, so the damaged part of the target organ 15 in contact with the balloon can be uniformly heated by radio frequency heating. Since the temperature distribution in the liquid contained in the balloon can be uniformized, the temperature of the liquid measured by the temperature sensor can be accurately consistent with the temperature of the target organ damage portion, and therefore the target organ damage portion can be accurately controlled temperature. The temperature distribution homogenizing device may be an agitation device for agitating the liquid contained in the balloon. The agitating device agitates the liquid to make the temperature distribution in the liquid uniform. The radio-frequency hot air balloon catheter may further include a rotating front sleeve placed on a front end portion of the inner rod to rotate around the axis of the catheter, and a rotated rear sleeve placed on the outer rod. A front part is rotated around the axis of the catheter, the invention explains the axis; and a rotation is basically, shot, and envy the lead in the temple so that the lead can be supplied here and the lead contains Count the electrode wire, W rotate; wherein the RF electrode package 3 must be electrically driven, so as to semi-privately apply to each other between the rotating front sleeve and the rotating rear sleeve, and the agitation device cover 3 is driven by a suspicious rotation. A device for driving the radio frequency electrode, the rotating front sleeve, the rotating rear sleeve, the lead wire and the rotating basic sleeve to make it rotate. The rotating drive of the stirring device is equipped with a garment 1 to drive the radio frequency electrode, the pre-rotation sleeve, the post-rotation sleeve, the lead and the rotation basic sleeve to rotate the pot to rotate the radio frequency electrode during the supply of radio frequency energy. . Therefore, to achieve a uniform RF energy supply, the stirring action of the 褙 Α transfer radio frequency electrode can be uniformized with the temperature distribution of the liquid. The radio frequency electrode includes several electrode wires to be connected in parallel to the pre-rotating sleeve and the post-rotating sleeve. Therefore, the RF electrode can be easily formed and can be evenly distributed in the balloon. Preferably, the linearly extending electrode wires forming the radio frequency electrode may be bent into a circular arc shape so that when the outer rod and the inner rod move axially with respect to each other to expand the balloon, they may be moved along an inner portion of the balloon. Surface extension. The liquid contained in the balloon can be effectively agitated by rotating the shooter electrodes to bend the electrode wires into an arc shape, and can generate a uniform radio frequency electric field. The lead wire can be spirally wound, and the rotation driving device can rotate the lead wire to rotate the radio frequency electrode. When the spirally wound lead is rotated in one direction, when the rotary drive device stops rotating the spirally wound lead, it can be rotated in the opposite direction to recover by its 584552 玖, invention description itself 5 Its natural shape. The rotary driving device can drive the pre-rotating sleeve, the post-rotating sleeve, the lead wire and the turning basic sleeve so that they rotate in opposite directions alternately: a predetermined number of revolutions can be borrowed by each of these opposite directions, After rotating the five sets of lube before the rotation, the sleeve after the turning, the lead wire of the book and the rotating basic sleeve, the rotation directions of the sleeve before the turning, the sleeve after the turning, the lead and the rotation basic sleeve are changed. Therefore, the radio frequency electrode can be simply rotated in opposite directions to agitate the liquid contained in the balloon by the radio frequency electrode. The agitation device may include a connecting tube connected to the outer rod and communicated with the balloon by a passage defined by the 104 outer rod and the inner rod; a vibration generating device for applying a vibration force to fill the The connecting tube and the liquid in the channel. The vibration generating device applies a vibration force to the liquid filled in the connecting pipe and the channel, and the vibration force is spread to the liquid 15 contained in the balloon and agitates the liquid contained in the balloon to be contained in the balloon. The temperature distribution of the liquid in the balloon is uniform. 4 The vibration generating device applies a vibration force to the liquid filling the connecting pipe and the channel, so that a vortex is generated in the liquid contained in the balloon. The vortex generated in the liquid contained in the balloon can effectively uniformize the temperature distribution of the liquid contained in the balloon. The temperature distribution of Guna's liquid in the balloon can be made uniform by circulating the liquid at a fixed temperature by the circulation device. The inner rod can be provided with a number of small nozzles in a part of the balloon, and the circulating farm can include a liquid supply device for the liquid to be supplied to the inner 8 玖, invention description rod to pass through the small 喑… Th shoots the liquid and can shoot the liquid in the balloon through the outer rod and the 4-channel suction channel of the f I 疋. The liquid supply device can spray the liquid through the outer rod and the small nozzle that can pass through the inner rod, and the channel defined by the inner rod reacquires the liquid- / RF f pole can be spirally coiled around the inner rod and extends to the Inside the balloon

▲ I5 position® This RF electrode can be easily placed inside the balloon for efficient RF heating. The balloon can be formed of antithrombogenic and demonogenic resin. The balloon can conform to all the necessary characteristics. The position can be a position on the patient's body, and the counter electrode is attached to the patient's body. The 垓 pre- 疋 position may be a position within a wall portion of the balloon or inside the balloon. 15 The predetermined position may be a position adjacent to the balloon.

The drawings briefly explain the above and other objects, features, and advantages of the present invention by the following detailed description, which will be understood with reference to the drawings, in which ... FIG. 1 is a radio-frequency hot-air balloon catheter 2 according to a first embodiment of the present invention 〇—a schematic perspective view of the front part; FIG. 2 is a schematic perspective view of the radio frequency hot air balloon catheter continuously behind the front part of the radio frequency hot air balloon catheter shown in FIG. 丨; FIG. 3 is a diagram for explaining the radio frequency Schematic diagram of the operation of the hot-air balloon catheter used in the electrical isolation of pulmonary blood vessels for atrial fibrillation treatment; 9 584552 (4) and 4 (b) of the invention description are the schematic diagrams of the balloon catheter, which are The state of being compressed for insertion into a pulmonary vessel, and the state of the balloon in contact with a target organ lesion; FIG. 5 is a schematic perspective view of a radio-frequency hot-air balloon catheter 5 according to the second embodiment of the present description; Figures 6 (b) and 6 (b) are schematic diagrams of the radio-frequency hot-air balloon catheter shown in Figure 5, respectively, in a state where the balloon is compressed for insertion into the femoral artery, and when the balloon is inflated to meet a target In contact adjacent the knitting; FIG piece goods for the first month • child B - schematic diagram of a heat treatment using the balloon catheter 10 of arteriosclerosis; and a portion of the FIG. Ϊ: Embodiment] Detailed description of the preferred embodiment 15 20 —The radio-frequency hot-air balloon catheter according to the first embodiment of the present invention will be described with reference to FIG. 4. As shown in Figure 丨 and Figure 2, a kind of radio-frequency hot gas Ά ^ 1 pack 3 " ~ Guide 4 'It consists of-the outer rod 2 and extending inside the outer rod 2 to slide relative to the outer rod 2- The inner rod 3 is composed of an inflatable balloon 6 ′ which is inflated to contact a target organ damage and extends between the outer rod 2 and the end of the inner rod 3. A radio frequency electrode 8 is arranged in the balloon 6. --- lead wire H), which is electrically connected to the radio frequency electrode 8, a thermocouple ^ is placed in the balloon 6 and can sense the temperature in the balloon 6, and an actuating device, namely, a temperature distribution uniformization device, Used to evenly distribute the temperature of the liquid contained in the balloon :. A wire 16 extends through the inner part 10, and the description of the invention is coaxial with the four guides 4. The guide wire 16 guides the catheter 4. — 2 7 The front sleeve 2G is placed in the saki 3 and extends inside the money ball 6 Put: == to rotate around: the axis of the catheter 4. -Turn the rear sleeve 21. Taxi ... One of the front ends of the stem 2 is used to rotate around the axis of the catheter *. The two-frequency electrode 8 includes a number of electrode wires 8a extending parallel to each other, such as between the sleeve and the sleeve 21 after the rotation. The wire 8a of the radio frequency electrode 8 extends substantially linearly when the money ball 6 is pressed. When the 6 mismatched rod 2 slides and expands relative to the inner rod 3,… is curved into an arc shape to extend along the inner surface of the balloon 6: 10 1 not shown in the figure. -Rotating the basic sleeve 23 is placed on the inner rod 3 to rotate about the axis of the catheter 4 near the rear end of the outer rod 2. The rotating basic sleeve 23 has a front end provided with a ring body 24, a rear end provided with a contact ring 15 20 M, and a middle portion provided with a gear 26 supported on a pantograph: electric brush 29 is in contact with the contact ring 25. An external thread 31 is formed on a rear end portion of the external rod 2. A nut 32 is screwed with the external thread 31. The o-ring 27 is placed on the rotating basic sleeve J 23 to seal the gap between the wire surface of the outer rod 2 and the outer surface of the rotating basic sleeve u to form a watertight type. Therefore, the clearance between the rotating basic sleeve M and the outer rod 2 and the clearance between the rotating basic sleeve 23 and the inner rod 3 are sealed into a watertight type sleeve 20 and the rotated sleeve 21. The inner rod 3 extends through the pre-rotation and the rotation basic sleeve 23. An external thread 33 is formed on a rear end portion of the rotating basic sleeve 23, and a nut 34 is screwed to the external thread 33. —O-ring 28㈣The outer surface of the inner rod 3 11 584552 玖, description of the invention and the gap between the inner surface of the rotating basic sleeve 23 forms a watertight type. «亥 Lead 10 is spirally coiled. One end of the lead wire is connected to the rotating sleeve 21 'and the other end is connected to the contact ring 25. The brush 29, which is in contact with the contact ring 25, is electrically connected to a radio frequency generator 40. The radio frequency energy generated by the radio frequency generator 40 is supplied to the radio frequency electrode 8 through the lead 10. The radio frequency generator supplies a radio frequency current of 13.56 Μ 于 ζ between the radio frequency electrode 8 and a counter electrode μ (Fig. 3) attached to the surface of the patient's body. For example, when the diameter of the balloon 6 is about 2.5 cm, radio frequency energy of 100 to 200 W is supplied to the radio frequency electrode 8. When a radio frequency 10 current is supplied between the radio frequency electrode 8 and the counter electrode 53 attached to the surface of the patient's body, the tissue 18 in contact with the balloon 6 is heated by a capacitor type of radio frequency heating. And was burned. The dielectric heating is generated around the electrode 8 inside the balloon 6 and is proportional to different dielectric constants. Therefore, the tissues 18 in contact with the balloon 6 are cauterized according to the principle of RF heating, that is, heat is generated on the contact portions of the dielectric members having different dielectric constants, respectively. A reduction gear 35 having gears 36 and 37 and a motor 38 is disposed close to the gear 26. The rotation of the output shaft of the motor 38 transmits a lower speed to the gear 26 via the gears 36 and 37. The motor 38 can be controlled 20 so that its output shaft rotates with a predetermined number of revolutions in a single direction, or it can be controlled so that its output shaft interacts with two full revolutions in the clockwise direction and two full revolutions in the counterclockwise direction. Way to rotate. The lead 10 is formed of a slightly hard material. When the motor 38 drives the rotating basic sleeve 23 fixed to the gear 26, the lead wire 10 connected to the ring body 12 玖, invention description 24 is rotated, and therefore, the sleeve 21, the radio frequency after the rotation The electrode 8 and the sleeve 20 before the rotation can be rotated. When the motor 38 is controlled to rotate the lead wire 10 in a single direction by a predetermined number of revolutions, the lead wire 10 is rotated in a direction opposite to the direction in which the lead wire 10 is spirally wound. When the motor 3δ is closed after turning the lead wire 10 by a predetermined number of revolutions, the lead wire 10 will automatically rotate in the opposite direction to restore its original shape. The radio-frequency electrode 8 can rotate and rotate the motor 38 in opposite directions by alternately starting and stopping the motor 38. When the motor 38 is controlled to rotate its output shaft clockwise with two full revolutions in the clockwise direction and counterclockwise with two full revolutions, the 0 far lead is made of an elastic material and has a flat shape to make the radio frequency. The electrodes 8 alternately rotate in opposite directions. 15 20

The moving device 14, that is, the temperature distribution homogenizing device, includes the pre-rotating sleeve 20, the post-rotating sleeve 2, the turning basic sleeve M, and the motor 38 to rotate the radio frequency electrode 8. The lead wire 1G transmits the rotational driving force of the motor 38 to the radio frequency electrode 8, and transmits radio frequency energy generated by the radio frequency generator 40 to the emitter electrode 8. The moving device M is used to reduce the local temperature difference generated in the heart ball 6, and the moving device M makes the temperature distribution of the liquid inside the balloon 6 uniform. At the rear end of the outer rod 2. The minute 3 is provided with a -ventilation tube and a contrast agent supply tube. The branch t 51 ^ messenger is opened to make the balloon 6 妯 milk, and then the contrast agent is supplied, and opened to supply a liquid, such as raw salt solution, to the balloon 6 to expand the balloon 6 . The inner rod 3 is provided with two inner cavities, that is, a first and a second inner cavity. The first 13 584552 玖, description of the invention The inner cavity is used as a space for extending the lead 16 and as a fluid passage. The second inner cavity is used as a space for extending a conductor for transmitting a signal provided by the thermocouple η attached to a middle portion of the exposed section of the inner rod 3. 5 The temperature of the liquid contained in the balloon 6 is measured with a thermocouple 12 attached to the inner rod 3. The conductor of the thermocouple 12 extends through the second inner cavity of the inner rod 3 and is connected to a thermometer 42. The thermometer 42 indicates the temperature of the liquid contained in the balloon 6. The balloon 6 is made of a thermally resistant, flexible, antithrombogenic resin. In an inflated state, the balloon 6 has an onion-like shape, as shown in FIG. 1. The radio frequency electrode 8 includes an equal number of electrode lines 8a. The number of such electrode wires 8a is in the range of several to several tens. When the inner # 3 is moved axially relative to the outer rod 2 to reduce the interval between the pre-rotation sleeve 20 and the post-rotation sleeve 15, the substantially linear electrode wires 8a are bent into an arc Shape ', so that the RF electrode 8 has a shape similar to a basket or onion head. If the Hongji wires 8a such as Hai are formed of a shape memory alloy, the electrode wires 8a can precisely change their shape to a substantially linear shape and an arc. Between shapes. The front and rear ends of the electrode wires 8a are covered with resin to prevent excessive radio-frequency heating of the front and rear ends of the electrode wires 8a. The radio frequency generator 40 supplies radio frequency power on the megahertz level, for example, 13.56 MHz to the radio frequency electrode 8. Thereby, heat can be generated by a capacitor RF to a part of the patient's body and generated between the RF electrode 8 and the counter electrode 53 attached to the back surface of the patient, as shown in FIG. 14 10 15 20 发明. Description of the invention The radio frequency electrode 8 is connected to the contact ring 25 of the rotating basic sleeve 23 through the spiral lead 10. The brush 29, which is cut on the pantograph, is said to be connected to the radio frequency generator 40. The brush 29 is kept in contact with the contact ring 25 to supply radio frequency energy to the radio frequency electrode 8. The radio frequency antenna 8 is rotated to generate a more uniform radio frequency electric field around the radio frequency electrode 8. The reduction gear 35 reduces the speed of the driver, that is, the rotation speed of the motor's% output, to a lower output speed. The rotational force of the motor 38 is transmitted to the rotating basic sleeve # 23 via the reduction gear 35 and the gear 26. The square box of the rotating earthen sleeve | 23 borrows the lead wire 5Q and transfers it to the rotating sleeve 2 fork to rotate the electrode wire 8a in the balloon 6. Therefore, the liquid-filled electrode wire 6a㈣ filled in the inflatable balloon 6 is used to prevent the irregular 'knives' due to convection and to make the temperature of the liquid filled in the balloon 6 uniform. Therefore, the temperature of the liquid in the central region of the balloon 6, the temperature of the liquid near the wall portion of the balloon 6, and the temperature of the tissue 18 in contact with the balloon 6 can be equal. Therefore, the temperature of the liquid in the central area of the balloon 6 measured by the thermocouple 12 and indicated by the thermometer 42 can accurately represent the temperature of the tissue in contact with the balloon 6. Time . The value of the helical fluid is measured when the energy of the shooter is supplied to the RF electrode $, and the thermocouple 12 set in the exposed section of the inner rod 3 is measured, and the X RF produces an output of 40 It is controlled in a feedback control mode so that the liquid filled in the button 6 can be heated at a good temperature. The tissue 18 in contact with the bulb 6 can be heated at an optimal temperature. The rotating basket-shaped RF electrode 8 is filled with the liquid of the balloon 6. Generate a more uniform radio frequency electric field and stir the temperature distribution in the liquid 15 玖, the description of the invention that the tissue 18 that can be uniform and in contact with the balloon 6 can be intensively heated to the desired temperature 0 The radio frequency hot air balloon will be explained in detail The operation of the catheter is applied to the electrical isolation of the pulmonary A tube for the treatment of atrial fibrillation. 5 FIG. 3 is a diagram for explaining the action of cauterizing the tissue 18 of the atrium 19 surrounding the pores W of the pulmonary blood vessel 17. The physiological salt solution is supplied into the balloon 6 through the branch tube 51 of the outer rod 2 and the circulation of the physiological salt solution outside the balloon 6 is repeated several times to purify the air of the balloon 6. As shown in FIG. 4 (a), the balloon 6 is compressed and the inner rod 3 is fully extended from the outer rod 2 10, so that the rotation of the sleeve 20 before the rotation and the sleeve 21 after the rotation The distance is increased to a limit, and the electrode wire of the radio frequency electrode 8 extends substantially linearly before the radio frequency hot-air balloon catheter 1 is inserted into the pulmonary blood vessel 17. In this state, the diameter of the balloon 6 is reduced to a minimum. Then, the balloon 6 is inserted into the lung enterprise tube 17. The radio-frequency hot-air balloon guide 15 is operated to place the balloon 6 near the target tissues 18. Then, as shown in FIG. 4 (b), the inner rod 3 is withdrawn, and a contrast agent and a physiological salt solution are supplied into the balloon 6 through the side branch officer 51 to inflate the balloon 6. Since the pre-rotation sleeve 20 is moved toward the post-rotation sleeve 21, the electrode wires 8a are bent into an arc shape. Thereby, the radio frequency electrode 8 is extended inside the balloon 6 in a basket shape 20. The radio-frequency hot-air balloon catheter i is continuously operated to bring the balloon 6 into contact with the target tissue μ. After that, the motor 38 is started to drive the rotating basic sleeve 23 for rotation by the reduction gear 35. The turning force of the rotating basic sleeve 23 is transmitted to the rotating sleeve 16 584552 by the spiral lead 10 extending through the catheter 4 and the invention description 21 °. Therefore, it extends into the balloon 6 in the shape of a basket. The RF electrode 8 is rotated to agitate the liquid filled in the balloon 6. ίο 15 Subsequently, the radio frequency generator 40 applies a radio frequency current, such as a radio frequency motor of 13.56MΗζ, to the counter electrode ^ attached to the back of the patient, and is connected to the radio frequency hot air balloon catheter i in a basket shape. Stretch the contact of the RF electrode between 25%. A radio frequency current flows through the brush 29 to make contact with the contact% 25. Therefore, the balloon 6 and the groups that are in contact with the balloon 6 are heated by a capacitor type heating with radio frequency dielectric heating attached. Regarding the temperature of the upper area of the balloon 6, if the liquid contained in the balloon 6 is not moved, it will be higher than the lower area of the balloon 6 due to convection, and the temperature of the liquid contained in the balloon 6 will be higher. The distribution can be evenly hooked by turning the liquid by the rotating RF electrode 8 extending in a blue shape. If the radio frequency electrode 8 is not aligned with the balloon 6 and is held in the balloon 6, the tissues 18 will be heated irregularly. Since the radio frequency electrode 8 is heated, a uniform RF electric field can be generated around the radio frequency electrode 8, and the balloon 6 and the tissues 18 are uniformly heated by radio frequency heating. The portion of the balloon 6 near the rotating sleeves 20 and 21 for the electrode wires to gather around has a tendency to overheat. Such overheating can be avoided by forming the sleeves 20 and 21 with a material having a small dielectric constant, such as resin or ceramic material, and / or by covering the electrode wires with resin, And / or avoid it by circulating cooling water through the inner rod 3. Therefore, the pulmonary blood vessel 17 can be electrically isolated by cauterizing the tissue 18 of the atrium 19 around the annular portion of the pulmonary enterprise tube 17 for the safe treatment of fibrous facial movements to the patient. 17 584552 Description of the invention ~ The radio-frequency hot-air balloon catheter 1 according to the second embodiment of the present invention is described in detail later. The radio-frequency hot-air balloon catheter package 3 is used to circulate the liquid in the balloon 6 to make the liquid temperature distribution uniform. A portion of the inner cymbal 3 extending inside the balloon 6 is provided with a number of small nozzles. The circulation 66 is used to keep the liquid being supplied in the inner tube 3, such as the liquid of 37 c, and a liquid supply device 62. 15 A liquid of a predetermined temperature controlled by the temperature controller 66 is supplied into the inner rod 3, and the liquid sprayed through the small nozzles 64 can be sucked through the annular space between the inner rod 3 and the -outer rod 2. The balloon 6 is inside. When inflated, the balloon 6 has an -ellipsoidal shape. A radio frequency electrode 8 is spirally wound around a portion of the inner rod 3 extending inside the balloon 6. The radio frequency electrode 8 is connected to the radio frequency by-lead H)! The temperature of the liquid contained in 4Ge contained in the balloon 6 is measured by a thermocouple 12 and monitored in a similar manner to the first embodiment described above, and the RF energy used to supply the RF electrode 8 is measured according to the amount Measured temperature to control. As shown in FIG. 5, the temperature controller 66 is controlled to, for example, 37 t: one of the circulating liquid 70 is heated at 44 ° C., while the circulating liquid 70 flows through the inner rod 3 and extends inside the balloon 6. Partially ejected through the small pouts 64 and flows into the balloon 6. The temperature of the circulating liquid 20 70 sprayed into the balloon 6 dropped to 43.5 ° C and further dropped to 43 ° C when the circulating liquid 70 reached the front end of the outer rod 2. Thereby, the circulating liquid 70 is circulated by the circulation system 60 so that the liquid contained in the balloon 6 is uniformly maintained at about 43.5 ° C. In the following, the radio frequency hot air balloon catheter 1 as shown in Fig. 5 is as shown in Fig. 7. The radio frequency hot air balloon catheter 1 shown in Fig. 5 applies 18 584552 玖, the description of the invention to the medical treatment of the arterial application site. 5 10 15 The balloon 6 of the radio-frequency hot-air balloon catheter 1 is compressed, and the radio-frequency hot-air balloon catheter 1 is inserted through the femoral artery 68 inside the diseased part of the carotid artery, as shown in Fig. 6 (a). Then, a contrast agent and a physiological salt solution are supplied to the balloon ㈣ through the branch f 51 on the outer rod 2 of the attachment material. Therefore, the balloon 6 is inflated to stretch the narrow part of the diseased part ⑼ as shown in FIG. In this state, an RF voltage of 13.3; 6mHz is applied across the RF electrode 8 and the counter electrode 53 attached to the back of the patient. ^ The circulation system 60 supplies a circulating liquid% such as 3rc to the inner cavity of "Hai Nei # 3" by pressurization. The circulating liquid claw heated by radio frequency is sprayed through the small nozzles 64 and sprayed into the balloon 6. The circulating liquid% flows through the balloon 6 'to make the temperature distribution inside the balloon 6 uniform, and is discharged through the inner cavity of the outer rod 2. When the balloon 6 is maintained at 43 ° C for 20 minutes or more, inflammatory cells or proliferating smooth muscle cells in the atherosclerotic lesion site 68 of the carotid artery will ride on ap_is, and The atherosclerotic lesion 68 can be stabilized. After that, the balloon 6 is compressed and the radio-frequency hot-air balloon catheter is withdrawn from the femoral artery. This radio frequency hot air balloon catheter! It can heat the diseased area 68 m evenly at an optimal temperature. Therefore, the 20th place of carotid artery atherosclerotic lesions 68 can pass the plan of these inflammatory cells or hypertrophic smooth muscle cells, ie the disturbed factor. Apoptosis can be stabilized by heating the carotid atherosclerotic lesion 6W 43 50c for 20 minutes or longer without affecting normal tissues, such as Endothelium. . Radiofrequency hot air balloon catheters can be applied to hyperthermia of cancer 19 584552 (Hyperthermia). It turns out that cancer cells can be controlled or eradicated by heating them at 43.5 ° C for 20 minutes or more. As shown in FIG. 8, a radio-frequency hot-air balloon catheter 1 according to a third embodiment of the present invention is shown. The radio-frequency hot-air balloon catheter 1 includes a balloon 6 and a 5 agitating device 80 for agitating and containing the balloon 6. To make the temperature distribution of the liquid uniform. The agitating device 80 includes a connecting tube 82 connected to an outer rod 2 to be opened to form an annular channel 83 defined by the outer rod 2, and an inner rod 3 extending through the outer rod 2 and a vibration generator 81, such as A vibration generates a 10-plate pump to apply a vibration force to fill the liquid in the annular channel 83. The connecting tube 82 communicates with the balloon 6 through the annular passage 83. A vibration force 86, such as about 1 Hz, generated by the vibration generator 81 spreads through the liquid filling the connecting tube 82 and the annular channel 83. Therefore, the liquid contained in the balloon 6 will generate thirst 85 due to the interaction between the actuated liquid and gravity. 15 These thirsts actuate the liquid through a variable direction during operation, so that the temperature distribution of the liquid contained in the balloon 6 can be homogenized. Thereby, the pulveroma formed in these tissues 68 can be homogenously heated at an optimal temperature. Similar to the RF electrode 8 shown in Fig. 5, one of the RF electrodes 8 spirally coiled around the inner rod 3 is used for RF heating. 20 # When the balloon 6 is formed of a suitable flexible material, the vibration force 86 'generated by the vibration generator 81 can generate a moderate vortex in the liquid contained in the balloon 6. It can be known from the foregoing that the radio-frequency hot-air balloon catheter of the present invention can heat the tissue in contact with the balloon by-

20 584552 发明 、 Explanation of the invention A full-three-dimensional necrotic surface is formed, which will not cause ulcers due to thrombosis or tissue burning. Therefore, the treatment of arrhythmia can be achieved safely and surely, for example, atrial fibrillation induced by extracardiac contraction from the isolation of the pulmonary veins and their pores through the pulmonary veins. 5 Because these tissues can be uniformly heated at an optimal temperature, planned heating of inflammatory cells or proliferating smooth muscle cells within unstable factors by heating an arteriosclerosis at a predetermined temperature (apotosis) ), Can stabilize the arteriosclerosis without affecting normal tissues, such as the endothelium. 10 BEST OF THE INVENTION The present invention has been described in detail with reference to its preferred embodiments to a certain degree of particularity, and it is apparent that many changes and modifications can be made therein. For example, the pure counter electrode 53 is placed on the surface of the patient's body. However, the position where the counter electrode 53 is provided is not limited to the surface of the patient's body. The counter electrode 53 may also be provided at the wall portion 15 of the balloon or inside the balloon 'or the counter electrode 53 may be provided at a position adjacent to the balloon. It is understood that the present invention may be implemented in a manner different from the specific description above without departing from the scope and spirit thereof. I! Brief description of the diagram] 20, Fig. 1 is an unintended perspective view of a radio-frequency hot-air balloon catheter / front according to the first embodiment of the present invention; Θ / radio-frequency hot gas pipe is continuously shown in Fig. 1 The schematic perspective view of the front and back of the radiofrequency hemp catheter; Figure 3 is used to illustrate the operation of the radiofrequency hot air balloon catheter in the application of heart isolation 21 584552 发明, the invention illustrates the electrical isolation of pulmonary blood vessels for atrial fibrillation treatment Schematic diagrams; Figures 4 (a) and 4 (b) are schematic diagrams of a balloon catheter when the balloon is compressed for insertion into a pulmonary vessel, and when the balloon is inflated to contact a target organ lesion 5; Figure 5 is an unintended perspective view of a radio-frequency hot-air balloon catheter according to a second embodiment of the present invention,

Figures 6 (a) and 6 (b) are schematic diagrams of the radio-frequency hot-air balloon catheter shown in Figure 5, respectively, when a balloon is compressed for insertion into the femoral artery, and when the balloon is inflated to communicate with A state of contact in the vicinity of a target tissue; FIG. 7 is a schematic diagram illustrating the use of a hot-air balloon catheter for treating arteriosclerosis; and FIG. 8 is a radio-frequency hot-air balloon catheter according to a third embodiment of the present invention Part of the figure. [Representation of the main components of the diagram]

1 ... radio frequency hot air balloon catheter 16 ... lead wire 2 ... outer rod 17 ... pulmonary blood vessel 3 ... inner rod 17quot ". Mao Mao 4 ... catheter 18 ... target tissue 6 ... balloon 19 ... atrium 8 ... RF electrode 20 · Turn the front sleeve 8a ... electrode wire. 21 ... turn the rear sleeve 10 ... lead 23 ... turn the basic sleeve 12 ... thermocouple 24 ... ring body 14 ... stirring device 25 ... contact ring 22 584552 玖, invention description 27,28 ... 0 ring 70 ... circulating liquid 29 ... brush 80 ... stirring device 31,33 ... external thread 81 ... vibration generator 32,34 ... nut 82 ... connection tube 35 ... reduction gear 83 ... ring channel 36,37 ... gear 85 ... vortex 38 ... motor 86 ... vibration force 40 ... RF generator 42 ... thermometer 5l ... branch tube 53 ... counter electrode 60 ... circulation system 62 ... liquid supply device 64 ... nozzle 66 ... temperature control Device 68 ... Diseased area

twenty three

Claims (1)

Patent application scope 1. A radio-frequency hot air balloon catheter, including a catheter composed of an outer rod and an inner rod, the inner rod extending through the outer rod to be slidable relative to the outer rod; k an inflatable balloon that can be inflated to make contact with a damaged part of the palace and is placed between the outer rod and the individual ends of the inner rod;-a radio frequency electrode for cooperating with a counter electrode for radio frequency The energy supply extends inside the wall of the shouting ball or inside the balloon, and the counter electrode is arranged at a predetermined position; a lead wire is electrically connected to the radio frequency electrode; 10 ′ is sensed, and the sensor contained in the balloon can be sensed. The temperature of the liquid: and-the temperature distribution uniformization device is used to make the temperature distribution of the liquid contained in the balloon uniform. 2. The radio-frequency type ball reduction catheter as described in the item of the patent application, wherein the temperature distribution homogenization device is an actuating device for actuating the liquid contained in the balloon. 3. The radio-frequency hot-air balloon catheter as described in item 2 of the patent application patent, further comprising: a rotating front sleeve placed on a front end portion of the inner rod to rotate around the axis of the 20 catheter; A rotating sleeve is placed on a front end of the outer rod to rotate around the axis of the catheter; and a basic sleeve is rotated to hold the lead so that radio frequency energy can be supplied to the lead and the lead can It is rotated; 24 584552. The scope of the patent application is that the radio frequency electrode includes several electrode wires to extend parallel to each other between the pre-rotating sleeve and the post-rotating sleeve, and the disturbance device includes a rotary driving device. In order to drive the RF electrode 4 to rotate, the sleeve, the sleeve after the rotation, the lead wire and the rotation basically 5 sleeve are caused to rotate. 4. The radio-frequency hot-air balloon catheter as described in item 3 of Shen μ College, wherein 4 radio-frequency electrodes include several electrode wires to be connected in parallel to the pre-rotating sleeve and the post-rotating sleeve. 5. The radio-frequency hot-air balloon catheter as described in item 4 of the patent, in which the 10 extensions > the linearly extending electrode wires that violate the radio frequency electrode can be bent into an arc shape so that when the outer rod and The inner rods move axially relative to each other so that the balloon can extend along an inner surface of the balloon when the balloon is inflated. 6. The radio-frequency hot-air balloon catheter according to item 3 of the scope of patent application, wherein the lead wire is spirally wound, and the rotary driving device rotates the lead wire to rotate the 15 RF electrode. / Qiao Shi / 7¾ radio frequency hot air balloon catheter, the rotary driving device drives the pre-rotating sleeve, the post-rotating sleeve, the 20 wire and the turning basic sleeve to rotate in opposite directions alternately, and by The number of rotations of each of the opposite directions, the rotation is changed after rotating the pre-rotation sleeve, ^ ^ sleeve, the lead and the rotation basic sleeve: official, the rotation sleeve, the m basic rotation Rotation of the casing The radio frequency hot air balloon catheter according to item 2 of the patent application, the agitating device comprises: Lu 25, a patent application scope connection officer connected to the outer rod, and by means of the outer rod and the inner rod boundary & The passage communicates with the balloon; and a motion generating device for applying a vibration force to the liquid filling the connecting pipe and the passage. 5 9 · The radio frequency hot air balloon catheter described in item 8 of the Chinese patent, which causes the vibration generating device to apply a vibration force to the liquid filling the connecting tube and the channel, so that the balloon is accommodated in the balloon Vortex is generated in the liquid inside. 10. The radio-frequency hot-air balloon catheter as described in item 1 of the scope of the patent of Shenying, wherein the temperature distribution homogenizing device is a circulation device for circulating the liquid contained in the 10 balloon, so that the liquid contained in the balloon The temperature distribution in the liquid in the balloon is uniform. U. The radio-frequency hot-air balloon catheter as described in item 10 of the scope of the patent application, wherein the nozzle is provided with a number of small nozzles at the portion where the inner rod extends, and the circulation device includes a liquid supply device for supplying liquid to the 15 In the inner cup, the liquid is sprayed through the small nozzles, and the liquid sprayed into the balloon can be sucked through the outer rod and the channel defined by the inner rod. 12. The radio-frequency hot-air balloon catheter according to any one of claims 8 to 10 in the scope of the patent application, wherein the radio frequency electrode is spirally coiled around the inner rod at a part inside the balloon. 20 13 · The radio-frequency hot-air balloon catheter according to item 1 of the scope of patent application, wherein the sah balloon is made of antithrombogenic and thermally resistant and pudding resin. 14. The radio-frequency hot-air balloon catheter according to item 1 of the scope of patent application, wherein the predetermined position is a position on the patient's body, and the counter electrode is attached to the body of the patient applying for patent scope. 15. The radio-frequency hot-air balloon catheter according to item 1 in the scope of patent application, wherein the predetermined position is a position in a wall portion of the balloon or inside the balloon. 05. According to item 1 in the scope of patent application The radio-frequency hot-air balloon catheter, wherein the predetermined position is a position adjacent to the balloon. % 27