TW561048B - Pharmaceutical compositions, based on volatile oils obtained from plants for use in the human and veterinary medical field - Google Patents

Abstract

The invention relates to pharmaceutical compounds which are based on the anti-inflammatory properties of etheric oils selected from the group consisting of Origanum vulgaris, Thymus vulgaris, Mentha piperita, Thymus serpilum, Saturea hortensis, Saturea montana, Saturea subricata, Carum corticum, Thymus zugis, Ocimum gratisimum, Moranda pungtata, Mosla japanoica and Salvia officinalis. Preferably the etheric oils, obtained at the distillation of Origanum vulgaris, Thymus vulgaris and/or Mentha piperita are used. Such pharmaceutical compounds, compared to synthetic sulfonamids, antibiotics and cortisones do not create biorecidives in the human body as well as in animal meat and milk and do not contribute to the resistance of microorganism against pharmaceutical compositions in general. The composition according to the invention can be used in the treatment of colibacillosis, dermatomycosis, lice, perspiration and fungus on feet, dermatitis, acne and of veterinary diseases like coccidiosis, mastitis, etc.

Description

561048 A7 B7 Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs 5. Description of the Invention 纟) Technical Field The present invention relates to pharmaceutical compositions including extracts from specific plant ether oils, methods for preparing such pharmaceutical compositions, and the composition Application of substances in the field of human veterinary medicine. Technical problem solved by the present invention One of the technical problems solved by the present invention is to prepare various human medicines with active natural components as the substrate, which successfully replaces the previous technology with sulfonamids, antibiotics, 1 7 -hydroxyl-1 1 Dehydrocorticosterone and the like are the underlying medicines, so the novel products according to the present invention are: 1 · Does not produce biorecidives in the human body; 2. Does not produce antimicrobial properties; 3. It is ecologically healthy; and 4 It is not toxic, mutant or deformed. Other problems solved by the present invention are the preparation of various veterinary medicines with active natural components as substrates, which have succeeded in replacing the prior art products with sulfonamids or antibiotics as substrates. The application of the active substance of the present invention eliminates the eight good effects caused by many prior art products (such as sulfonamids and antimicrobial properties), such as: 1. the presence of biorecidives in animal meat and milk treated with such products; and 2. prior art products Must be antimicrobial-bacterial. Previous technical description (please read the note on the back page) This paper size is applicable to Chinese National Standard (CNS) A4 size (210X297 mm) · 4. 561048 A7 B7 Printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs Description of the Invention 4) Medicines known in the prior art are used to treat human diseases, such as: cholera, coliform, dermatophytosis, oral and throat mucosal infections, various causes, and treatment of purulent wounds with at least antibiotic, sulfonamid or Based on active substances of hormonal or corticoid origin. The trend of modern science is that ecological health drugs replace some of the drugs based on this source. The ecological health drugs are more affordable for humans and have a more favorable impact on human health. The same assessment is made for veterinary drugs used to treat animal diseases that use antibiotics, sulfonamid and even hormones as the substrate, such as various coliform diseases, dermatophytosis, breast infections, vaginal and ovary infections, various causes and coccidia disease. To avoid these unnecessary consequences, ecologically healthy and trusted products must be used to address the above-mentioned veterinary diseases. More specifically, a large number of bacteria that cause the above diseases have developed a form of resistance to medicines of the prior art, so the products of the present invention are used to solve the problems of the above diseases, as well as various abdominal inflammation, gastritis, stomatitis, otitis, Combined with meningitis. Based on the above point of view, FR-A_2,706,770 discloses a pharmaceutical composition against tuberculosis, which uses seven essential oils extracted from plants as the substrate: E uc η 1 ytusg 1 〇bu 1 us , Melaleuca leucadendron, thyme, Humulus lupulus, Eugenia caryophylata, peppermint and Organum vulgaris. However, F R — A 2 ', 7 0, 7 7 0 does not disclose the use of the oil mixture for the treatment of any other diseases or other components thereof. On the other hand, Annales Pharmaceutiques Francaises, Vol. 43, (Read the notes on the back and write this page first) This paper size is applicable to Chinese National Standard (CNS) Α4 specification (210 × 297 mm) -5-561048 A7 B7 V. Description of the invention $) η〇.1,1 085,77-81 shows only the fungicidal activity of forty plant extracts against nine molds. However, it does not point out that the plant extract can be used as a pharmaceutical composition in the human and veterinary fields, and even use any of the above diseases and conditions. The explanation of the above-mentioned problem solving method is applied to the main component of the pharmaceutical composition of the present invention is an ether type oil, which is derived from any of the following plants: oregano, thyme, peppermint, Thymus serpilum, Saturea hortensis, Saturea montana, Saturea subricata, Carum corticum, Thymus Zugis, Ocimum gratisimum, Moranda pungtata, Mosla japanoica and Salvia officinalis. Preferred ether oils are made from any of the following plants: oregano, thyme and peppermint. The best ether oils are at least from oregano and selectively from thyme. The Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs of the People's Republic of China mu aMemaiw v ^ m HJ-— — — ^ iaBIBBi ^^ 1 (Please read the notes on the back first \ ^! ^ 马 页) In the case of veterinary medicine, you can also Synthetic thymol with the chemical name isopropylcresol was used. In addition, tannic acid compounds may be used in the veterinary composition. The tannic acid can be collected by extracting the leaves and flowers of the oregano plant, and the leaves and flowers of the oregano plant are obtained by distilling the ether-type oil (see below). The pharmaceutical composition of the present invention includes a pharmaceutically acceptable carrier, preferably from a natural source. Representative examples of these carriers are those skilled in the art of human yang and veterinary medicine. Examples of such carriers are lactose, honey, laurel, petrolatum, paraffin, starch products, calcium carbonate and the like. The pharmaceutical composition can be in any form suitable for its application, for example, the size of glued paper is applicable to Chinese National Standard (CNS) A4 (210X 297 mm) · 6 561048 A7 B7 V. Description of the invention 4) Capsules, syrup, Tinctures, ointments, powders, emulsions, pastes, etc. The content of the active agent in the pharmaceutical composition of the present invention can be changed within wide limits, and in fact it depends on the pharmaceutical use. The active agent is preferably present in an amount of 1 to 15% by weight, and most preferably 4 to 10% by weight, which is calculated based on the total weight of the pharmaceutical composition. In addition, the active agent of the present invention can also use other active materials, preferably from natural sources. These substances may have bacterial, fungicidal, and astringent properties. The following dosages of the pharmaceutical composition in powder form (including 5% by weight of oregano oil and 95% by weight calcium carbonate) can be used for holistic and individual treatments: A) Holistic treatment = preventive dose: pig, rabbit, calf: per 500 grams of powdered chicken, duck, and turkey used per ton of feed: 450 grams of powder used per ton of feed printed by the Consumers' Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs. Pigs, rabbits, calves: per ton of feed Use 1000 grams of powdered chicken, duck, and turkey: This paper size applies the Chinese National Standard (CNS) A4 (210X297 mm) -7-561048 A7 B7 V. Description of the invention 纟) 9 0 per ton of feed 0 grams of powder treatment for 7-10 days B) Individual treatment: calves, ponies: 0 · 20 — 0 · 25 grams per kilogram of piglets, lambs, lambs: 0 · 1 grams per kilogram of body weight The pharmacological activity of oregano ether oils (oregano oil), the table below exemplifies oregano oil's "antibiotic resistance" ··-I-I ....... _ »=-I- 1-- I-n (Please read the note on the back ^^ matter page first) Order * Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs This paper size applies to China National Standard (CNS) A4 (210X297 mm) _ 8-561048 kl

7 B

V. Description of the invention, 6) Table A. The strength of microbiological effects printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs, Staphylococcus aureus 氺 * This Treponema hyodsiaenteriae 氺 氺 氺 氺 Erysipelothrix insidiosa * * * Pasteurella polydemic 氺 * * * Streptococcus faecalis 链 Streptococcus agalactiae 氺 氺 * Proteus mirabilis 氺 common Proteus 氺 * 氺 Proteus rayi 氺 本 氺 氺 Escherichia coli * 氺 * Vibrio coli * * 氺 * Salmonella species 氺 氺* * Streptococcus pyogenes amin. C * * 氺 pneumoniae * 氺 氺 Enterobacter aero genes * 氺 氺 Corynebacterium pyogenes * * 氺 Streptococcus papillae 氺 氺 氺 Candida species * 氺 Pseudomonas aeruginosa 氺 氺 氺 Tuberculosis 氺Species of this fungus * Species of white mold 氺 氺 氺 cryptosporidiae spp Species of coccidiosis * 〇 Drug resistance; * Relatively sensitive * * Moderately sensitive * * * Very sensitive * * * * Extremely sensitive The dimensions of this paper are applicable to the Chinese National Standard (CNS) A4 (210X 297 mm) 561048 A7 — B7 V. Description of the invention f) Information in Table A above It is pointed out that diseases caused by the microorganisms in Table A can be treated using pharmaceutical preparations containing oregano oil as an active ingredient. As mentioned above, the pharmaceutical composition is particularly used for the prevention and treatment of humans and is particularly suitable for the treatment of gastrointestinal infections in animals. It is caused by bacteria, molds, etc .; see the following list: Pigs: E. coli, Salmonella species, swine dysentery, Bath Poultry species: (chicken, duck, turkey): Coccidia (coccidiosis), Salmonella, Pasteurella rabbits: Coccidia (coccidiosis), Salmonella dairy cows · Calf-E. Coli, Pasteurella species, Salmonella species Lamb: Salmonella species, Pasteurella species, Clostridium perfringens, E. coli goat: (Lamb): Salmonella species, Pakistan In addition to the above diseases, the pharmaceutical composition of the present invention can be used to treat: Animals and humans caused by Toxoplasma gondii Venomplasma protozoan;-Canine body parasitic disease caused by Ascaris canis and canine larvae;-Myosinosis of dogs, livestock, poultry, and humans; Ascaris of pigs and poultry, by Ascaris Caused by suum and tapeworm; oxurosis equi of equine and heteroacidosis of poultry; national standard (CNS) A4 size of this paper rule (210X297 public attack). 10- 561048 A7 B7 Printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs Description of the invention $)-human tsutsugamushi and pig cysticercosis; human tsutsugamushi and oxyurocis; rheumatism, such as arthritis, spondilitis, dyscioathie, and damage, such as distorsio, subluxatio, etc .; Plant molds and insects;-dog tsutsugamushi disease,-diarrhea, caused by E. coli (coliform disease), salmonella (salmonellosis), Pasteurella (pasteurosis), streptococcus (Streptococcus), Vibrio coli (coliform), Treponema hyodsiaenteriae (diarrhea of hemorrhagic rickets) and other types of diarrhea in humans and animals;-parasitic diseases, by Cryptosporidia spp, ascaridia spp, tapeworm species, venom Caused by protozoan species, atoxoplasmosa;-Human and animal diseases caused by Candida albicans, Pseudomonas species, Cryptococcus neoformans, white mold species, Clostridium species Disease; and-tsutsugamushi disease in birds and poultry. The composition of the present invention, especially the powder form including 5% oregano oil, can also be used for the preservation of human food and the preservation of animal feed to extend the shelf life of these products. The method of extracting the ether type oil from the above plants (especially oregano, thyme and peppermint) is carried out by means of steam (steam) distillation. First, leave the plant's leaves and flowers (must be dry) in the evaporator. When the prepared oils are used in human applications, the distillation of oils from various plants is carried out separately, which indicates the different types of distillation during the distillation process (please read the precautions on the back before this page) € This paper size applies Chinese National Standard (CNS) A4 specification (210X 297 mm) -11 _561048 Μ B7__ V. Description of the invention _) Plants cannot be mixed together. The distiller must have two outlet pipes: one for oil outlet and one for water vapor (vapor). The water pan is placed under the dried parts (leaf and flower) of the plant and heated to 100 t, preferably at a pressure of about 20 bar. When the pressure is increased, the distillation time can be reduced. This water vapor passes through the dried part of the plant, thus generating oil droplets. Water vapor droplets are lighter than oil droplets and therefore flow out of the outlet tube below the extractor. The oil droplets flow out of the oil outlet pipe and flow into a pan for holding the oil. This process takes 3 hours. Its yield is 100 kg of dried plants producing 3-6 kg of oil. Usually the extracted oil contains a specific percentage of tymol and carvacrol. About 3% tymol and 60-70% carvacrol. After the above-mentioned distillation, the leaves and flowers are used to extract tannic acid, which can be particularly added to veterinary pharmaceutical compositions. A more detailed process for the preparation of ether-type oils from oregano plants consists of four steps: Step 1: Select the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs to print and use the existing oregano plants as the base, which can already be obtained with about 91% Oregano plant seeds of active material: 8 6-8 8% carvacrol and 3-5 thymol. 8-10% of the residue includes the following components: linal0, barneo1, cimeii, and some less important components. Step 2: Plant the plant. The paper size applies the Chinese National Standard (CNS) A4 specification (210X297 mm) -12-561048. Printed by the Consumers Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs. A7 —___ B7 V. Description of the invention 彳 ο) will be based on The seeds obtained in the steps are planted in good loose soil, preferably in a subtropical climate. During this period, all agricultural techniques were used, such as irrigation and artificial fertilization. Use only leaves and flowers that have grown. The harvest must take place in the early morning and evening hours when the plant blooms. Step 3: Dry the leaves and flowers The drying process is performed in a special room, that is, under the drying room. The harvested leaves and flowers cannot be directly exposed to the sun, as any exposure to the sun is sufficient to reduce the percentage of the active substance. The leaves and flowers are arranged in layers from 20 to 25 cm thick. During the first three days, the layer was turned over four times manually or mechanically every day to make the drying process uniform. These drying chambers are constructed in such a way that the air can always circulate freely. The drying process lasts about 7-8 days. Step 4: Manufacture the oil Distillation of the oil is performed from the dried leaves and flowers of the plant by a traditional steam distillation method. 5-7 kg of oil are made from 100 kg of dried leaves and flowers. After the distillation step to obtain the oil, the following steps are carried out:-The oil is heated at 187 ° C. The process is also carried out in the distiller to evaporate unimportant substances. The residue is an important substance: carvacrol 8 6-8 8%; thymol 3-This paper is in accordance with Chinese National Standard (CNS) A4 (2Ι〇χ297 mm) -13- 561048 A7 B7 V. Description of the invention 彳 1) 5% and a small amount: Lunburn, barneol, linalol, etc. After the re-distillation, the oil was cooled to room temperature, and then placed in an airtight container made of aluminum or dark glass. The following examples illustrate the present invention, namely (A) composition and preparation examples related to human pharmaceuticals, (B) composition and preparation examples related to veterinary pharmaceuticals, and (C) activities related to pharmaceutical compositions of the present invention. Examples and (D) Examples concerning the safety of the pharmaceutical composition of the present invention. Unless stated otherwise, the percentages are expressed by weight. (A) Composition and preparation of human pharmaceutical medicine Example 1 Medicine for treating coliform disease, salmonellosis, pasteurosis, vibriosis, and cholera: these diseases may be caused by E. coli and rodent injury Diseases caused by bacteria, Vibrio abortus, and Pasteurella multocida 1.1 The process of manufacturing capsules The material components of the medicine are: 1Ϊ printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs-90-92% lactose per cow To oil 4—6% —thyme oil 2-4% —pepper peppermint oil 0.5-1.5% First, put about 30% of lactose in a vacuum with all oils. This paper is in accordance with China National Standard (CNS) A4 specifications (210X297 mm) -14 _ 561048 A7 B7 V. Description of the invention (1) 2). The mixture was mixed for 5 minutes at 2000 revolutions per minute. Then the remaining lactose was added and each substance was mixed with each other at the above rate for 0 minutes. Finally, the powder was filled into capsules. 1 · 2 The process of making the syrup is based on the ingredients of the medicine: 92-94% honey—oregano oil 2—4% thyme oil 1-3% —pepper peppermint oil 0.5—1.5% 30% of the total amount of fluid honey is placed in a vacuum mixer and all the oil is added. The mixture was mixed at 200 revolutions per minute for 15 minutes. Then add the remaining honey and mix each substance at the above rate for 15 minutes. The product formed is a liquid syrup that can be packaged immediately after cooling. Printed in Example 2 by the Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs. 1 Medicine used to treat dermatophytosis: Dermatophytosis may be caused by Trychophiton sp. And microspore strains 2.1. Manufacture The constituent elements of the medicine for the preparation of tincture are: The paper size applies to the Chinese National Standard (CNS) A4 (210x297 mm) -15-561048 A7 B7 V. Description of the invention ¢ 3 Polyethylene glycol laurel-cow To oil-thyme oil-pepper peppermint oil 7 2-7 4% 19-21% 3-5% 1-3% 0.5-1.5% Heat about 30% of polyethylene glycol in a vacuum mixer up to 5 5 ° C. Add all the oil and mix the mixture for 5 minutes at 2000 rpm. Finally, the remaining polyethylene glycol is added, and the laurel is added, and the mixture is mixed at the above speed for five minutes or more. After cooling, the product is ready for packaging. 2.2 The process of manufacturing ointment The material constituents of preparing the ointment are: (Please read the precautions on the back before ^ r on this page) Order-Printed by the Employees' Cooperative of the Central Standards Bureau of the Ministry of Economy-Vaseline Gum Arabic-Liquid Paraffin-oregano oil-thyme oil-pepper peppermint oil 6 7-6 9% 2 4-26% 3-5% 1-3% 0.5-1.5% 30% petroleum jelly in a vacuum mixer with 4 5 ° C melting temperature. Add this oil and mix each paper at a speed of 250 revolutions per minute. Applicable Chinese National Standard (CNS) A4 size (210X 297 mm) -16-561048 A7 _ B7 V. Description of the invention 彳 4) Substance 10 minutes. Then add the remaining petroleum jelly and liquid paraffin. Then each substance was mixed with each other for 10 minutes at the above temperature, and Example 3, which was packaged after cooling, was used to treat vaginitis (female extension) Yukichi Ping Trychomonos genetalis. The components of the substance for preparing the medicine were: vagina The inflammation may be caused by (please read the precautions on the back before ^^ this page) L # too-starch dextrose-hygroscopic carrier-colloid-oregano oil—100 S * sesame oil—Klamath grass oil 5 1-53% 19-21% 19-21% 2-4% 2-4% 1-3%

1. The printing process of 1T Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs is as follows: Put the starch dextrose and the hygroscopic carrier in a vacuum mixer. The aforementioned amount of oil was added to the mixture, and each substance was mixed at 200 revolutions per minute. Finally, the colloid is added and each substance is mixed again, and then packaged. Example 4 Products of anti-lice and oxidative skin insects: for example, anti-mosquitoes and flies. The constituent elements of this medicine are: The paper size is applicable to Chinese National Standard (CNS) A4 (21 OX 297 mm) -17-561048 A7 B7 V. Description of the invention (is)-laurel 91-93% 1 oregano oil 4-6% thyme oil 2-4% All the above parts are placed in a vacuum mixer. Mix together at 200 revolutions per minute, after which the mixture is packaged. The advantage of this product over chemical products is that it uses lidane as the substrate. It is based on the medicine of the present invention and is completely non-toxic to humans and animals. Example 5 Products for preventing foot sweat and the presence of foot mold: Trichophyton sp. And microspores. Materials used in the preparation of these medical procedures:-calcium carbonate 91-93%-oregano Oil 4 — 6% One hundred miles of sesame oil 2-4% Printed by the Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs Put about 30% of calcium carbonate in a vacuum mixer with all the oil. The mixture was mixed at 200 revolutions per minute for 10 minutes, after which the remaining calcium carbonate was added. This mixing is continued until a powder is obtained. Example 6 This paper size applies the Chinese National Standard (CNS) A4 specification (210X297 mm) -18 _561048 A7 B7 V. Description of the invention 卩 6) Products of insects and other pests: such as mosquitoes and flies preparing these medical processes Materials used:-Calcium Carbonate-Oregano Oil-Thyme Oil 9 1-9 3% 4-6% 2-4% Put about 30% of calcium carbonate in a vacuum mixer with all the oil. The mixture was mixed for 10 minutes at 200 revolutions per minute. Subsequently, the remaining calcium carbonate is added and the mixing is continued until a powder is made. Example 7 Preparation of these medicines for the treatment of dermatitis, acne and other dermatitis of the face: Substances printed by Laurel-ethanol-oregano oil-thyme oil 7-2-7 4% 19-21% 3-5% 2-4% Put 30% laurel with all the oil in a vacuum mixer ° Mix the mixture at a stomach speed of 200 rpm for 10 minutes. The product is then 'add the remaining laurel and ethanol' and packaged in a dark glass bottle ° This paper size applies Chinese National Standard (CNS) A4 (2 Sichuan x 297 Gongchu) -19- 561048 A7 B7 Central Standard of the Ministry of Economic Affairs Yin Fan, Consumer Cooperative of the Bureau of the People ’s Republic of China 5. Description of the Invention 疒) Example I Oral Paeonia _ Preparation of the substances used in these medical processes: a natural medicine powder 94 96% oregano oil 2-4% one hundred sesame oil 1-3% Put 30% of the natural medicine powder and all the oil in a vacuum mixer. Mix together at 200 revolutions per minute for 10 minutes. Subsequently, the remaining natural medicinal powder is added. The product is packaged in a sachet or an aluminum tube under pressure. (B) Composition and Preparation of Veterinary Medicine and Medicine Example 9 Treatment of E. coli disease in animals and gastrointestinal diseases: E. coli disease may be caused by E. coli and other species: Salmonella, Pasteurella, Vibrio, Borrelia 、 Hiodysenterie and Cryptosporidiosae sp. 9.1 The process of powder manufacturing The materials used to manufacture powders for the treatment of E.coli disease: —Calcium carbonate 91—93% —oregano oil 4—6% (please read the precautions on the back and then copy the PC copy) Page) Too much ...

H This paper size is applicable to Chinese National Standard (CNS) A4 specification (210x297 mm) -20 561048 A7 B7 V. Description of the invention (is) One hundred miles sesame oil 2-4% peppermint oil 0.5-1.5% —tannin 0.5 — 1.5% Put 30% of the total calcium carbonate in the vacuum mixer, and gradually add all the ether type oils. The whole product was mixed together at a speed of 250 revolutions per minute for 10 minutes. The ether type oils were mixed directly before purification in the mixer. After 10 minutes of mixing, the remaining calcium carbonate was added and mixed for another 5 minutes at the above rate. The powder is then ready for packaging. 9.2 One of the examples of materials used in the process of manufacturing emulsions to produce powders for the treatment of E. coli is:-polyethylene glycol 89.5-91.5%-oregano oil 3--5%-thyme oil 1-3%-pepper Peppermint oil 0.5, 5-1.5%-Tannic acid 0.5-1.5%-Glyceryl monostearate 1--2% Printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs and in the second instance Substances used: 91-93% laurel oil, 3-5% oregano oil This paper size applies to Chinese National Standard (CNS) A4 specifications (21〇X 297 Gongchu) -21-561048 Α7 Β7 Central Ministry of Economic Affairs Printed by the Bureau of Standards Consumer Cooperatives V. Invention Description (19-Thyme Oil-Peppermint Oil-Tannin 1-3% 0.5-1.5% 0.5-1.5% The process of the two examples is the same. First, 30% of the The substrate was placed in an impeller-type vacuum mixer (the first example is the polyethylene glycol and the second example is the laurel oil), and the oil mixture was added to mix each substance at a speed of 200 revolutions per minute for 5 minutes. Then add the remaining substrate. In the first example also add the glyceryl monostearate. Mix again in the same way 1 0 minutes. Finally, it was packed in dark glass bottles. 3 The process of making capsules The materials used in the preparation of this product are:-lactose-oregano oil-thyme oil-peppermint oil-tannin 9 1- 9 3% 3-5% 1-3% 0 · 5-1 · 5% 0 · 5-1 · 5% First, mix the three oils at the given percentages. In the mixer at 200 revolutions per minute Blend the mixture with 30% lactose for 10 minutes. Then add the remaining lactose and mix again. Finally 'fill the mixture in capsules. This paper size applies the Chinese National Standard (CNS) A4 specification (210X297 mm) ) -22-Please read the back first · Attention

Item · Η II Order 561048 A7 B7 V. Description of the invention) 9 · 4 Process of manufacturing paste The elements used in this process are:-Vaseline gum arabic-oregano oil-thyme oil-peppermint oil-tannic acid-liquid Paraffin 6 9-7 1% 3-5% 1-3% 0.5-1.5% 0-5-1.5% 2 1-2 3% The process of this paste is as follows: Put Vaseline Gum Arabic in the mixer and total Ingredients are mixed at 20% and heated to 40 ° C. The heated person was then added to the above amount of oil, and the product was mixed at a rotation speed of 1,000 per minute for 5 minutes. Finally add the liquid paraffin and package the product-^ --- ^ ------- (please read the precautions on the back first and then this page), D-printed by the staff consumer cooperative of the Central Standards Bureau of the Ministry of Economic Affairs ^ Implementation Example 1 10 For the treatment and prevention of coccidiosis in living animals: Coccidiosis may be caused by Eimeria tenella, Eimeria phasani, Eimeria mecatrix, Eimeria duodenalis, Eimeria acervulina, Eimeria colchici, Eimeria maxima, Eimeria praecox, Eimeria brunetti, Eimeria hagani , Eimeria mitis, Eimeria mivoti The substance used in the manufacture of this product is: This paper size applies to Chinese National Standard (CNS) A4 (210X 297 mm) -23-561048 A7 B7 Employees' Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs Printed 5. Description of invention)-Calcium carbonate_Oregano oil-thyme oil-pepper peppermint oil 9 2-9 4% 3-5% 1-3% 0.5-1.5% Put 20% of this calcium carbonate in the impeller In a vacuum mixer, add all the oil that has been mixed in advance. The product was mixed at 200 revolutions per minute for 10 minutes. The remaining calcium carbonate was then added and mixed for another 10 minutes. The product is finally packaged. Example 11 1 Product used to treat mastitis: Mastitis can be caused by Streptococcus papillae, Staphylococcus aureus, Escherichia coli, Cryptococcus neoformans, Candida albicans, Spheroforus necroforus, Streptococcus agalactiae Material:-Vaseline Gum Arabic-Liquid Paraffin-Oregano Oil-Peppermint Oil 9 2-9 4% 2 2-2 4% 3-5% 0.5-1.5% Put 20% Vaseline Gum Arabic in advance at 4 5 ° C heated mixer. After the substance is melted, add a given amount of oil mixture, and order each (please read the notes on the back to write this page). Η This paper size is applicable to China National Standard (CNS) Α4 specification (210X297 mm) _ 24- 561048 kl _ B7 V. Description of the invention 2) Minutes at a speed of 200 rpm for 5 minutes. When the product is cooled, the remaining petroleum jelly and the paraffin wax of Bibu are added. The product is then packaged in a suitable syringe. Example 1 2 Products with anti-proinflammatory properties: Dermatitis may be caused by dermatophytosis, and may be caused by Trichophyton sp. (Trychophiton sp.) And microspore species. The substance used in the preparation of this product ： (Please read the notes on the back first_ 舄 this page) -Vaseline Gum Arabic-Liquid Paraffin-Oregano Oil-Thyme Oil-Peppermint Oil 6 9-7 1% 2 1-2 3% 3-5% 2 -4% 0.5-1.5%. Printed by the Consumers Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs. Put 20% Vaseline Gum Arabic in a mixer heated at 45 ° C beforehand. The oil was added and the product was mixed at 50 revolutions per minute for 10 minutes. Then add the remaining vaseline gum and liquid paraffin. The product is finally cooled and packaged in a suitable tube. Example 1 The material used to treat animal wounds for the preparation of the product is: -25- This paper size applies the Chinese National Standard (CNS) A4 specification (210 × 297 mm) ¥ 56104 A7 B7 V. Description of the invention b)-Medical powder 9 2-9 4%-Oregano oil 4-6%-Thyme oil 0 · 5-1.5%-Peppermint oil 0 · 5-1.5% Put 20% of the medical powder in a vacuum In a mixer, mix with oil that has been mixed in advance. The mixture was blended at a speed of 2000 revolutions per minute for 10 minutes. The remaining medicinal powder was then added and mixed for an additional 5 minutes at 150 rpm. Finally, the powder is packed in a bag or a pressure bottle. (C) Examples of veterinary and pharmacological activities of the present invention Example 14 Introduction Coccidiosis is the most common severe disease in modern poultry breeding. The disease is caused by a single intracellular parasite of the coccidia species, and its pathogenicity depends on the disease and the level of mortality. To prevent and eradicate this coccidia, many chemotherapy treatments have been used, but the problem is that these parasites are resistant ', especially when used improperly and unchanged. Therefore, the poultry's immune protection (vaccine) has been started using the preparation of the present invention, which preparation comprises 5% by weight oregano oil and 9 5% Ca C03, which is hereinafter referred to as `` Preparation A 〃 ''. Materials and manufacturing methods The test was performed on 75 Hybron breeders. The chicken is kept in a kit (please read the precautions on the back and then click on this page). The original copy is printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs. The paper size applies to the Chinese National Standard (CNS) A4 (210X297 mm) -26- 561048 Printed by the Consumer Cooperatives of the Central Bureau of Standards of the Ministry of Economic Affairs A7 B7__ V. Description of the invention b) Mini farms with landing systems and raised at standard concentrations "arbitrary". At the beginning of the test, divided into each group 25. Group A: 25 chickens were added to food at a preventive dose at a day's age. Preparation A was 0.25 g / kg within 7 days. After 7 days, it was found that E. Tenalla and E. Acervulima were infected with oocysts. The chickens were routinely examined for fecal examination 28 days after the infection. After 28 days, the chickens were killed and examined for parasitic sites and fecal examinations. Group B : In this chicken, 25 chickens were given a coccidia-free and tested substance A concentrate. After 7 days, they showed infection with E. Tenalla and E. Acervulima oocysts. On the same day, Preparation A and the Animal food was mixed at a concentration of 0.5 g / kg of food. The chicken was fed with food mixed in this way for seven days, and then routine fecal examination was started when the infection was measured. After 28 days, the chicken was killed and its parasitic site and fecal examination were checked. Group C : Among 25 chickens in this group, they were reared on pure feed for 7 days, and after 7 days, they were infected with E. Tenalla and E. Acervulima oocysts. After clinically found the disease (after the 7th day of infection), they started to be infected. The food was mixed with the concentrate of Preparation A at a concentration of 0.5 g / kg of food. This treatment lasted 7 days and a routine stool test was performed. When the chicken was 28 days old, the chicken was killed, Check for parasitic sites and feces. The bird has been infected with E. Tenalla and E. Acervulima oocyst tetrenic isolates, and sprouts are tested at a dose of 1 X 105 oocysts after standard application. Standard parasitology methods To carry out this test: proposed by jiohnson.; [And Reid W · M at 1970. Anticoccidial drugs: The paper size in chicken cages was applied to chickens in accordance with Chinese National Standard (CNS) A4 specifications (210 × 297 mm) ) -27- 561048 Central Standard of the Ministry of Economic Affairs A7 B7 printed by the Bureau ’s Consumer Cooperatives__V. Description of the invention) The lesion scorion technique and the Floar pen experiment, Exp. Parasitol. 28, 30-36. This inspection was performed on the first day after the chickens were moved throughout the experiment, and Performed within two days after infection. Test results and discussion The animal was found to be infected with parasites by inspection on the first day after the chickens were removed. Tests were performed within two days after infection. Of the three experimental groups, group A and group B had no coccidia in their feces during the experiment. In group C, the clinical symptoms of coccidiosis (diarrhea, characteristic behavior ...) and the presence of coccidia oocysts in the feces were found on the 6th day after infection. After the second day of treatment, diarrhea stopped, but coccidia oocysts were still found in the stool. After the fourth day, the number of oocysts decreased significantly, after which it had been reduced to a minimum. After the fifth day of treatment, the clinical symptoms of the disease have stopped. No chickens died. The chicken was killed, and its parasites and feces were examined by Johnson. J and Reid (1970), loc.cit. No coccidiosis was found in groups A and B, and it was not particularly important in group C (based on the level of this scale + 1, and no more than this) ° Based on preliminary experiments, it can be concluded that preparation A is applied to poultry Coccidiosis, and has good avoidance and treatment effect. The preparation contains 5% oregano flower and leaf ether type oil, which is effective for the intestinal tract, and may be the cause of clinically found that the infected digestive tract does not change before the application of this treatment. In this group, the bird was found to recover quickly and grow normally. It has been found that the poultry normally consumes the administered food, and the strong odor is usually absorbed by the food and therefore undetectable. The powder is conducive to making the thick paper used for poultry applicable to the Chinese National Standard (CNS) A4 specification (210X297 mm). · 561048 Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs. The preferred form of homogenization. When the experiment continued, it was found that the poultry consumed all the food at will, and that microclimate changes within the optimum limits of this product provided the animal with the optimal space. Conclusion: Based on the experiments performed, the use of Preparation A to prevent and kill coccidiosis in rearing chickens may include the following:-Preparations with a concentration of 0.25 g / kg of food can successfully prevent this disease. The preparation must be added to food for 7 days-the preparation at a concentration of 0.25 g / kg of food can be used in the initial and clinical diagnosis of coccidiosis. The treatment must last 7 days; the preparation is easily mixed with food. The preparation has a strong, distinctive odor but cannot be tasted in food. Chicks will normally eat the food mixed with the preparation;-in the treated chicken, no side effects caused by the application of the preparation are found;-the preparation can be used for preventive or therapeutic purposes, and can also be used in other poultry disease. Example 15 Introduction As in Example 14, coccidiosis is the most common parasitic disease of poultry, such as widely-raised maggots. The most common clinical disease occurred in _4-This paper size applies to Chinese National Standard (CNS) A4 (210X 297 mm) -29- 561048 A7 B7 Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs ) Six weeks old, the output has been greatly reduced. Eradication of coccidiosis prevention and treatment is the same as poultry production with the same treatment. There are also problems with resistance in this case. Therefore, the preventive and therapeutic effects of Formulation A (as defined in Example 14) were tested, and the results showed that this formulation had a significant effect in this test. Materials and methods used: Tests performed at 3 to 6 weeks old. Note that clinically occurring coccidiosis appears to occur at 4 to 6 weeks old. According to the production dynamics of the market, there are about 2000 animals in each group. This experiment was performed on three groups. Group A: After three weeks of parasitic examination of the big cockroach, no cocci were found, and the formulation was added to the feed. When used for prevention, the formulation is continuously administered at a feed concentration of 0.25 g / kg for seven days. Group B: This group was 2 to 4 days old, and the postmortem examination revealed the initial stage of cocci infection. Observe the changes of several cocci and pathogens in the small intestine to evaluate the degree of infection. The type of pathogen is determined based on its morphological characteristics. After diagnosis, the formulation dose was continuously given at a concentration of 0.5 g / kg feed. Group C: In this group, the 4-week-old spring pheasant has obvious clinical symptoms of the disease. Birds and diarrhea in this group are very obvious. Hemorrhagic enteritis was found and the mycosis was planted in the cecum. The death limit for this pupae is between 50 and 60 per day. Formulation A was used at a feed concentration of 0.5 g / kg. Coccidiosis is diagnosed by taking a sample of its feces and examining it using standard parasitology methods. A mucosal smear was performed from the diseased bowel lesion area. The degree of infection and the strict paper size are in accordance with Chinese National Standard (CNS) A4 (210X 29 * 7 mm) -30- 561048 A7 ____ B7 V. Description of the invention: Severity test is based on the degree of pathological changes to count cocci oocysts And evaluation. Norton's method is used to determine the morphological characteristics of the parasite. Test results and discussion Group A: Formulation A obtained sufficient coccidiosis stabilization effect. In this group, no cocci were observed during the three-week period (ending at the end of the sixth week). No parasite component (coccus oocysts) was found at the autopsy. The pupae grows normally and the mortality rate is lower than the technical range predicted for this yield (average 1.1%). Group B ... The initial symptoms of infection in this group have been infected by E. Du u d e n a 1 i s and E. C ο 1 c h i c i. Mortality is within the technical range, but symptoms of infection are visible. After seven days of treatment, the symptoms completely disappeared. At the post-mortem examination, the bowel and coccum of the sacrificed animals were free of pathological changes specific to coccidiosis. A mucosal smear test showed that the disease did not spread. Printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs Group C: This group has shown clinical symptoms of coccidiosis with a mortality rate of 2.5%. This is an infection caused by E. Duodenalis and E. Colchici. Treatment was performed for seven days. Mortality has decreased significantly in the first three days. After the treatment was completed, it was found to be completely cured. This is certified by a postmortem and parasitological test of the death moth. Among the two groups in which infection was found, the bird's condition and health improved significantly after treatment. After these birds have been kept for several weeks, they have found that their motility and development are at their best. After assessing and measuring mortality, due to worsening weather conditions (substantial decrease in temperature, heavy rain, and windy wind), the mortality rate increased slightly in the second week after observation, but according to the paper size of the dead animal, the country of China is applicable. Standard (CNS) A4 specification (210X297 mm) -31-561048 Μ _____ B7 V. Description of the invention yesterday) Anatomy (72 in Group B, 61 in Group C, and 60 in Group A) and dead animals and experiments Parasitic examination of the excreta of the group revealed no coccidiosis. Conclusion: Based on the experiments performed, using Preparation A to prevent and kill pheasant game bird I coccidiosis, which may include the following ...-Preparation of food at a concentration of 0.25 g / kg Can successfully prevent the disease. The preparation must be added to food for 7 days >-The preparation with a concentration of 0.5 to 50 g / kg of food can be used in the initial and clinical diagnosis of coccidiosis. The treatment must last 7 days; the preparation is easily mixed with food. The preparation has a strong, distinctive odor but cannot be tasted in food.鴂 Normally eat food mixed with the preparation;-In the treated pimple, no side effects caused by the application of the preparation have been found; printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs-the preparation can be used to prevent or Therapeutic use, for bacterial or fungal diseases. Based on its effect on coccidiosis, it can also be applied to other coccidia (bred from three to eight weeks old). (D) Examples of safety of veterinary pharmaceutical drugs of the present invention. Examples 16 and 1. Introduction This example conducts a research to obtain more information about the ether including oregano. The paper size applies Chinese National Standard (CNS) A4. Specifications (210X 297mm) 561048 A7 V. Description of the invention $ 0) Oil (oregano oil) pharmaceutical composition is safe for chicks. For this purpose, two levels of food intake are included in the experiment: the normal recommended level is 250 P Pm oregano oil, and the recommended level is 10 times the dose level (2,500 p p m oregano oil). In order to comply with the EU-registration of C o n c i 1 d i r e c t i v e (C 0 M C93 11 3) and Council decision (C0M (93) 114), the latter dose is usually used to test the safety of the product. A commercially available antiviral product, Virginiamycin, was used as a reference product in the experiments. Place the birds in the cage for 3 to 4 days. Research criteria are weight gain, feed ingested, feed conversion efficiency, water intake and general health. 2. Experimental process 2.1 Experimental groups The following four experimental groups are involved in this experiment: (Please read the precautions on the back before writing this page) 舾 衣 · 太 定 · Printed by the Staff Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs Group Food I Matrix Food (Controlled Food Without Antibiotics) Π Matrix Food * 250 ppm oregano oil m Matrix Food * 2,500 ppm oregano oil IV Matrix Food * 20 ppm oregano oil per experimental group Includes 90 chicks, six replicated cages, and 15 females in each cage. 2.2 Animals The dimensions of this paper apply to Chinese National Standard (CNS) A4 (210X297 mm) -33-561048 A7 B7 5. Description of the invention $ 1) Use of breeding broilers (', Ross 〃). At the beginning, 4 60 day-old females were randomly divided into 2 4 cages. During the five-day test period, all birds were reared on a standard diet. At the age of 5 days, 360 rats were selected and randomly divided into experimental groups based on body weight. The configuration was completed in this way, obtaining 15 birds with an average weight of 114 grams in two cages per group, 107 grams in two cages, and 102 grams in two cages. After the chickens were configured, they were reared experimentally for 29 days (age 5-34 days old). 2.3 Changes The birds were vaccinated with Newcastle disease (according to the distribution method) when they were one day and four days old. 2.4 Chicken House Printed by the Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs Make the chicken live in a chicken cage in a broiler house that has been heated, ventilated and lit. The broiler house consists of 72 cages. Each cage has a metal net, and its floor space is 0. 98 square feet. Each cage has a water dispenser and feeder. Close 1 to 15 birds per cage. The cage is illuminated for 2 to 4 hours. During the experiment, gradually reduce the light intensity. The temperature of the chicken cage unit gradually decreased from 2 8 t during the first week to 2 3 ° C on the last day. During the experiment, the humidity of this chicken cage unit was about 55%. 2.5 Ingestion For this experiment, a batch of feed was used. The composition of the matrix food is shown in -34- This paper size is applicable to the Chinese National Standard (CNS) A4 specification (210X297 mm) 561048 A7 ________ B7 V. Description of the invention 彳 2) is shown in Table B. No coccidia were added to this diet. The experimental diet was prepared with a feed mixing device. The substrate 飮 food system of this experiment was mixed in a batch in all groups. The prepared experimental food was then divided into four batches' to which the required amount of feed additive was added and mixed. Next, the food was granulated (2.5 mm) without adding steam. The granulation temperature was measured after the particles were flattened, and it was about 5 4 ° C. The contents of this matrix are crude protein, Ca and P. Feed this feed ad libitum. You can also drink water arbitrarily via an automatic device. The paper size of the printed papers printed by the employees' cooperatives of the Central Bureau of Standards of the Ministry of Economic Affairs applies to the Chinese National Standard (CNS) A4 (210X29 * 7 mm) -35-561048 A7 B7 V. Description of the invention Table _Basic food Composition (expressed in%) 中央 Printed by the Consumer Cooperatives of the Central Bureau of Standards of the Ministry of Economic Affairs Wheat 35.00 Corn 10.00 Soy oil 3.10 Animal fat 3.00 Tapioca flour 3.94 Pea flour 10.00 Soy flour (47.6% CP) 15.00 Heat treated soybeans 5.00 Sunflower flour 5.00 Meat residue (58% C RP) 5.00 Feather crumbs (hydr.82% CP) 1.50 Vitamin-mineral mixture * 1.00 Limestone 0.88 Monocalcium orthoacid 0.92 Salt 0.26 L-Lionine 0.20 D 1 -Methionamine Acid 0.20 Crude Protein 22.3 (21.9) Digested Crude Protein 18.3 ME Chicken (kcal / kg) 2900 ME Rooster (kcal / kg) 3140 Crude Fat 9.4 Crude Fiber 3.6 Ash 5.8 Calcium 0.86 (0.85) Phosphorus 0.71 (0.73) Effective P 0.4 5 Sodium 0.16 Potassium 0.8 5 Chlorine 0.28 Magnesium 0.16 Linoleic Acid 3.0 Total Amino Acid AFD Amino Acid 1.28 1.09 Methionine 0.54 0.48 Methionine • Crystal 0.94 0.79 Threonine 0.82 0.67 Tryptophan 0.24 0.20 Isoleucine 0.90 0.76 Leucine 1.65 1.40 Phenylalanine 1.03 0.88 Tyrosine 0.70 0.58 Valine 1.06 0.87 Arginine 1.48 1.28 Histamine 0.51 0.43 (Please read the notes on the back first ^ Write this page)

、 1T This paper size applies Chinese National Standard (CNS) A4 specification (210X 297mm)-Er-561048 A7 V. Description of the invention ") * Supply per kg of feed: riboflavin, 4 mg; nicotinamide, 40 Pen grams; d-pantothenic acid, 12 mg; bile chloride, 500 mg; amin, 15 micrograms; D1 10-tocopheryl acetate, 15 mg '2 ~ methylnaphthoquinone 5 mg; retinyl acetate , 3.44 mg; bilirubinol, 50 μg; biotin, 0.1 mg; folic acid, 0.75 mg; Feso4. 7H2, 0,300 mg; Mn0, 100 mg; CuS〇4 5H20, 100 mg; ZnS04.H20, 150 mg; Na2Se03, 0. 15 mg; K1, 5 mg; CoS 0.47H2 0, 1 mg; antioxidant (ethoxyquin), 100 mg; and second-generation virginian. ** Digestible amino acids visible to the naked eye in excreta. () Analytical content (please read the precautions on the back before ^ T this page)

Γ Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs 3. Research Standards-Individual body weights in experiments 14 and 29 days. -The feed consumption of 15 birds per group is based on the weight of each time. -The feed conversion efficiency is based on kilograms of feed consumed / kg of weight gain. Ten counts are based on the weight of each time. The feed consumption and conversion efficiency data can accurately estimate the feed consumed by dead birds during the experiment. Water and feed intake for 15 birds per group over a four-day period (2 4-28 days old). -Mortality and general health. ft This paper size is in accordance with Chinese National Standard (CNS) A4 (210X29 * 7mm) -37- 561048 A7 B7 i. Description of the invention $ 5) 4 · Static analysis Static analysis Weight gain, feed conversion efficiency, feed intake and water t 'Consumption results. Correct gender error and ‘non-professional’ weight gain, feed intake and feed conversion efficiency results. The following minimal importance test was then used to test the significance of the variation in the different experimental groups. The analysis of the variation was calculated using the computer program SPSS / PC * V5.0 (Norusis, 1 992). ○ All important statements are based on P ^ 〇 · 〇 5. 5 · CONCLUSION Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs The results of weight gain, daily feed intake and feed conversion efficiency during the 14 and 29-day experimental period are shown in Tables C and D. Supplying 250 or 2,500 ppm of oregano oil in the diet has no effect on weight gain and feed conversion efficiency during the 14 and 29 day experiments. The addition of virginiamycin to the diets used to increase body weight and feed conversion efficiency during the 14-day experimental period did not have any effect on the broilers obtained during the 29-day experimental period. Water intake and water / feed ratio are shown in Table E. Ingestions containing 250 or 2,500 ppm oregano oil or 20 P pm virginiamycin are not effective in terms of water intake to water / feed ratio. Low mortality, 1.4% (= 5 animals), which was not significantly different in each treatment group. In addition, there were no abnormal health conditions during the experiment. The low mortality rate obtained during this experiment indicates that the animal is in good health. The good health of the birds in this study may explain the fact that the observed effect of Virginiamycin on broilers is difficult, but this paper size applies the Chinese National Standard (CNS) A4 specification (210X 297 gt)- 38-561048 A7 B7 V. Description of the invention and) An improvement in feed conversion efficiency can usually be observed. Based on the results of this research, it can be concluded that when oregano oil is supplied at 10 times the recommended level, it has no negative or adverse effects on the chicken's health performance.

Table C: Results of weight gain, daily feed intake, and feed conversion efficiency of chickens during the 14-day experimental period (5-19 days old). Adding weight to feed increases feed intake (g)% (g / d) )% Ratio% I-585 100 60.6 100 1.450 100 Π 250 ppm oregano oil 577 98.6 59.4 98.0 1.441 99.4 Π 2,500 ppm oregano 582 99.5 60.3 99.6 1.452 100.1 IV oil 592 101.1 60.5 99.8 1.431 98.7 20 ppm virginian LSD (P 14 1.0 0.021 ^ 0,05) Printed by the Consumer Cooperatives of the Central Bureau of Standards of the Ministry of Economic Affairs This paper is printed in accordance with Chinese National Standard (CNS) A4 (210X29 * 7mm) -39-561048

7 7 AB V. Description of Invention $ 7) Table D Results of weight gain, daily feed intake and feed conversion efficiency of chickens during the 29-day experimental period (5-34 days old). Sample and material (g)% (g / d)% Ratio% I-1590 100 93.7 100 1.710 100 Π 250 ppm oregano oil 1571 98.8 92.2 98.3 1.702 99.5 Π 2,500 ppm oregano 1593 100.2 94.0 100.3 1.711 100.1 IV oil 1606 100.3 93.4 99.6 1.697 99.3 20 ppm Virginiane LSD (P 38 1.9 0.024 ^ 0.05) Printed on the paper by the Consumers' Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs. The paper size is applicable to the Chinese National Standard (CNS) A4 specification (210X 297 mm)- 40-561048 A7 7 Β V. Description of the invention) Table E. Results of water consumption and water feed ratio for chicks over a four-day period (2 4 — 2 8 days old). Ratio (g / d)% Ratio% I-291 100 2.06 100 Π 250 ppm oregano oil 295 101.3 2.07 100.7 Π 2,500 ppm oregano oil 295 100.3 2.09 101.4 IV 20 ppm Virginianine 290 99.6 2.08 101.2 LSD (P ^ 0.05) 1 3.2 0.07 (Please read the notes on the back ^^ write this page)

Printed by the Consumer Cooperatives of the Central Bureau of Standards of the Ministry of Economic Affairs This paper is sized to the Chinese National Standard (CNS) Α4 (210X 297 mm) -41-

Claims (1)

561048 A8 B8 C8 D8 附件 、 Appendix 2a for patent application scope: Patent application No. 86 1 1 83 19 (without underline after amendment) Chinese patent application scope replaces the amendment on September 15, 1992 of the Republic of China A composition comprising an active ingredient and a pharmaceutically acceptable carrier, characterized in that the active ingredient is thymol and / or carvacrol, which is present in oregano (QTiganum vulgads) The content of the vegetable-extracted oil is 1 to 15% by weight based on the total weight of the composition. 2. The composition according to item 1 of the scope of patent application, characterized in that the pharmaceutical carrier is a natural source. 3. The composition according to item 2 of the scope of patent application, characterized in that the pharmacological carrier is selected from the group consisting of lactose, honey, laurel, petrolatum, stone extract, starch products or calcium carbonate. 4 _ If the composition of any one of items 1 to 3 of the scope of patent application, characterized in that the content of the active ingredient is 4 to 10% by weight based on the total weight of the composition 5. The composition according to any one of 3 items, characterized in that the composition, especially a veterinary composition, contains tannic acid. 6. The composition according to item 5 of the scope of patent application, characterized in that the content of tannic acid in the composition is 0.5 to 2.5% by weight based on the total weight of the composition. 7. The composition according to any one of claims 1 to 3, characterized in that the active ingredient is of natural origin. This paper size applies the Chinese National Standard (CNS) A4 specification (21〇 > < 297 mm) (Please read the notes on the back before filling out this page) Ordered by the Intellectual Property Bureau of the Ministry of Economic Affairs and printed by the Consumer Cooperatives 561048 A8 B8 C8 _________D8 _ VI. Scope of Patent Application 8 · The composition of any one of the items 1 to 3 of the scope of patent application, which is used to prevent and treat microbial gastrointestinal diseases. 9. The composition according to any one of claims 1 to 3, which is used to prevent and treat skin diseases. 1 0. A composition according to any one of claims 1 to 3 of the scope of patent application ′, which is used to fight insects. · (Please read the precautions on the back before filling in this page) * 11 Line · Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs This paper applies the Chinese National Standard (CNS) A4 standard (210X297 mm) -2-