五 、發明説明 A7 B7 —In 1 - - 經濟部智慧財產局員工消費合作社印製 本發明係關於—種膠凝分古 維素膠。本發明特別，包含…菜芬及-種纖 劑，含有二二及：種膠凝牙膏，包含-種黏合 、k 、 芬 種纖維素膠，如羧甲基纖雉妾， ^配物t ’以提供—種具有低黏稠性之 牙喜且* 】好稠度，維持良好物理安定性，以相當低之黏:劑: 歧 對於牙V製造者，牙膏條之黏稠性在歷史上及今曰爲一 重要考慮參數。大量製i土去曲_ & m > 、一 I込者典型使用母分鐘可裝填80至 ，告二心：裝填線包裝牙膏於層壓管中。爲符合此製 口而 要者爲牙霄條精確地由管切斷。若牙膏保切於 層壓管之密封部份，管之密封可能失敗，導致管:^牙 I條由管溢出亦可能引起管密封區域之外部變黑，因爲在 =封時燃燒所致p在製造期間，打開及變黑之管去除。在 消費者万面’黏稠性牙膏在使用期間會使牙膏噴嘴有破爛 外觀。這些問題爲拖尾（tails)或黏稠性牙膏所固有。爲避 免或減少此問題，需要一種可精確切斷之牙膏調配物，即 不黏調或拖尾之牙膏。 牙膏一般含有一種磨光劑或磨擦劑，潤濕劑，增稠劑或 黏合劑，水，發泡劑，及調味劑。潤濕劑及水亦共同稱爲 媒液。此外，可併入提供治療或化粧用途之劑，如氟化物 及酒石控制劑。爲提供一種非黏稠性牙膏，調配物必須維 持消費者習慣之其他極佳物理性質。爲滿足消費者者，這 些性質應提供牙膏令人心動之味道，良好清潔效果，容易 -4 本紙張尺度適用中國國家標準（CNS ) M規格（210>< 297公釐） I I I -- I J - J 於本-- (請先閱竣背面之漆意事項再) 線 冲洗，極佳口味，化學及物理安定性。此外，這些性質應 提供於成本上對於消費者有利之牙膏。 牙霄之凋配物性質依黏合劑，磨擦劑，潤濕劑，水，及 調配物之其他成份而定，亦依這些成份於複合混合物中如 何互相作用而定。一般而言，黏稠性由牙膏調配物中所用 之黏合劑及磨擦劑之種類及量而定。在較少程度，黏稠性 亦受潤濕劑之選擇所影響。在一般所用之黏合劑中，例 如，竣曱基纖維素（CMC) —般已知可增進黏稠性，而鹿角 菜苷會減少黏稠性。在一般所用之磨擦劑中，矽石一般較 白要及瑪酸二鈣（DCP)可增進黏稠性。 經 濟 部 智 慧 財 產 局 員 X 消 費 合 作 社 印 製 一般術語「鹿角菜甞」用於成打衍生自海草之相似多 醣。所有鹿角菜苷含有重複之半乳糖單元以交替之卢i — 3 及α 1 4醣苷键結連接，且部份硫酸化。鹿角菜甞之種類 部份可以硫酸化程度區分。％鹿角菜苷具有重複單元D-半 乳糖-4-硫酸酯-3,6-酐半乳糖，提供硫酸酯含量約18 至2 5 %。L鹿角菜甞具有重複單元D _半乳糖_ 4 _硫酸酯_ 3,6-酐-D-半乳糖-2-硫酸酯，提供硫酸酯含量約25至 34%。λ鹿角菜苷具有重複單元0_半乳糖_2_硫酸酯半 乳糖-2，6 -二硫酸g旨，提供硫酸g旨含量約3 〇至4 〇 %。 鹿角菜苷形成搖變性膠凝。已報告該膠凝顯示極佳之擦 出性，香味釋放，及沖洗性。％及t鹿角菜苷用作膠凝牙 膏之黏合劑已知亦可提供非黏稠性牙膏。然而，美國專利 4,604,280述及一個使用鹿角菜苷所製造之組合物之有關之 問題，當該組合物在低於膠凝-溶膠溫度之溫度進行機械操 ______-5- 本紙張尺度適用中國國家標準（CNS ) A4規格（210 X 297公釐） 537902 A7 --- -B7 五、發明説明（3 ) ^ 作時，該組合物之稠性或黏性容易減少。對於鹿角菜嘗， 膠凝-溶膠溫度在約451至49。(：之範圍内。低於此溫度之 小操作有時可引起黏性實質減少。爲補償此黏性之喪失， 通常需要使用額外量之鹿角菜甞於調配物中。因此，鹿角 菜荅通常以1%過量之重量濃度使用。 在已用於牙膏調配物中之鹿角菜苷種類L ，％ ，及几 中，L鹿角菜嘗一般較佳。其部份因爲硬化效果之差異所 致。相對於基於L鹿角菜苷之膠凝，已報告基於％鹿角菜 苷之膠凝在架上較易硬化。以此方式硬化之牙膏難由管中 擠出。相對於基於t鹿角菜苷之膠凝，基於％鹿角菜苷之 膠凝亦可能具有脱水收縮問題，即水可能由膠凝分離。若 相分離不安定，牙膏產品視爲不可接受。因爲這些理由， 當鹿角菜苷用作膠凝牙膏之黏合劑時，一般選擇6形式。 本發明之一目的爲提供一種非黏稠性膠凝牙膏，其包含 %鹿角菜谷作爲黏合劑之主要成份，而無上述與％鹿角菜 善有之妥定性問題。另一目的爲提供一種％鹿角菜答之濃 度相當低之牙膏。 發明之 現在已發現一種含有％鹿角菜苷及一種纖維素膠之黏合 劑於牙嘗調配物中’提供一種牙膏具有令人驚奇之非黏稠 性’顯示良好稠度及物理安定性。該牙膏亦可調配成具有 極佳透明性。調配物中黏合劑濃度之重量百分率在約〇 3 〇 至0.8 0 %範圍内。黏合劑中％鹿角菜甞對纖維素膠之重量 比例在約2 5 : 7 5至7 5 : 2 5範圍内。黏合劑之較佳濃度在 ’ —3~—____________ - 6 - 本紙張尺度朝巾國i家標準（CNS ) A4規格（21()X 297^J~i '---- (請先閲I背面之：/-£>意事項再c .裝 經濟部智慧財產局員工消費合作社印製 ^7902 A7 B7 五、發明説明（4 ____ 約0M至0·65之範ϋ内，％鹿角㈣對纖維素膠之較佳比 (請先閲讀背面之注意事項再頁} 例在、、4 5 5 · 4 5至7 5 : 2 5範圍内。較佳之纖維素膠爲複甲 基纖維素（C M C)。 發明之詳細説明 本發明係關於一種牙膏，包含一種含有此鹿角菜苷及一 種纖維素膠之黏合劑於調配物中，其爲非黏稠性，且有良 好稠度，it明性，及顯示良好物理安定性。本發明；克服 纖維素膠（域甲基纖維素或CMC)有關之黏稠性問題及尤 鹿角菜菩有關之脱水收縮及安定性問題。由混合纖維素膠 及％鹿角菜苷所獲得之黏合劑可用於標準膠凝牙膏中，以 提供一種牙膏爲非黏稠性，對於水及調味劑分離長時間安 定，具有良好Cuban値（具有良好稠度），及長時間無可感 知之硬化。黏合劑可以相當低濃度使用，其爲成本考慮^ 重要因素。 經濟部智慧財產局員工消費合作社印製 本發明提供一種牙膏組合物，其包含一種經口可接受之 媒液，一種磨光劑，一種表面活性劑，及一種黏合劑，該 黏合劑含有％鹿角菜菩及一種纖維素膠，黏合劑濃度之重 量百分率在約0.30至0.80%範圍内，冗鹿角菜苷對^維素 膠之比例在約25 : 75至75 : 25範圍内。本發明之重要特 點爲（a)黏合劑濃度之重量百分率，及（b)黏合劑中％鹿角 菜苷對纖維素膠之重量比例。黏合劑之較佳濃度在約〇 45 至0.65%範圍内。黏合劑之更佳濃度在約〇 45至〇 61%之 間。％鹿角菜苷對纖維素膠之較佳比例在約5 5 ·· 4 5至 7 5 ·· 2 5範圍内。更佳比例在約6 0 ·· 4 0至7 5 : 2 5之間，而 本紙張尺度適用中國國家標準（CNS )八4規格（210>< 297公釐） 五 '發明説明（ 5 A? B7 ，佳比例在約62 : 3 8至71 : 29之間。黏合劑中纖維素膠 此鹿角菜苷可呈乾燥摻合混合物共處理混合物之形式， 任一形式均適合。該混合物可依據此技藝中—般已知 法製備。 可用於本發明中之纖維素膠包括一般適用於牙膏中作爲 膠增稠劑者。該膠之實例爲經乙基纖維素，輕丙基纖維 素’及效曱基纖維素。本文中所用之術語「纖維素膠」表 任-纖維素膠或其組合物。較佳膠爲羧甲基纖維素。 牙T 一般包含-種媒液，—種磨光劑，一種黏合劑，及 -種表面活性劑及清潔劑。此外，可併人提供治療或化粒 用途之劑，如琺瑯硬化劑，酒石控制劑，變白劑，及抗細 2劑。一或多種甜化劑及調味劑選擇性加入以令消費者滿 思。右需要，二氧化鈥亦可加人作爲乳白劑或 此牙膏之媒液爲經口可接受之媒液，包含水及潤濕劑， 如3至6個碳之多元醇，其中各碳羥基化，及其混合物。潤 濕劑之實例包括甘油，山梨糖醇，聚乙二醇，聚氧乙二 醇，甘露糖醇，木糖醇，及其他糖醇。山梨糖醇及甘油較 佳。 經濟部智慧財產局員工消費合作社印製 適用於本發明牙膏中之磨光劑或磨擦劑包括細粉分剖之 水不溶性粉末物質，許多爲熟習技藝人士周知者。這些物 質具有磨光活性，但無過度磨擦性。實例包㈣酸二舞， 鱗酸三_，偏蹲酸納，、结晶以，膠體以，複合銘矽酸 鹽，碳酸鈣，竣酸鍰，磷酸鎂，焦鱗酸鈣，膨土，滑石， 矽酸鈣，鋁酸鈣’氧化銘，及矽石乾膠凝。較佳之磨擦劑 -8- 表紙張尺度適用中國國家禕準（CNS ) A4規格（210X297公釐） 537902 A7 B7 五、發明説明（6 經濟部智慧財產局員工消費合作社印製 爲碎石基磨擦劑。 可用於本發明牙v中I表面活性劑(清潔劑)爲—般 乳化或均W散牙膏成份者。清潔劑—般較佳爲陰離子性 或非離子性或其混合物。陰離子清潔劑之適合軸包括月 ㈣㈣納，脂肪酸_甘油疏酸鹽，脂肪酸硫酸鹽，高燒 基方基％酸鹽，南烷基磺酸基醋酸鹽，高烯磺酸鹽，高脂 族酿基酿胺或低脂族胺«酸，高垸基聚㈣氧基（3至 100個烷氧基)硫酸鹽，及脂肪酸肥包。這些陰離子清潔劑 t實例包括月桂基硫酸鈉，氫化椰丨油脂膀酸一甘油一硫 酸鈉，N -月桂醯基肉胺酸鈉，及椰子油酸（cMMe)鈉。非 離子性清潔劑之適合種類包括低環氧烷鏈，如環氧乙烷及 環氧丙垸。 k擇1生加入之其他物質包括調味劑，瑞鄉硬化劑，及抗 細菌化合物。調味劑物質之實例包括甜化劑糖精，香精 浚、、彔薄％ (spearmint)，薄荷，鹿蹄草（wintergreen)， ’由加利树，檸檬，及莱姆（lime)之油。硬化劑之實例包括 一氟磷酸鈉，氟化鈉，及氟化錫。抗細菌劑之實例爲苯曱 酸納’ 一氯苯氧氯驗（tricl〇san)，及對襄苯曱酸（parasept) 甲酯或乙酯。 本發明之牙膏可製備呈不透明或透明。不添加乳白劑， 牙嘗具有良好透明性。二氧化鈦爲較佳之乳白劑，可加入 以提供不透明之牙膏，不會影響調配物之物理特徵。 本發明之牙貧調配物可以熟習技藝人士周知之方式製 備在周圍溫度進行之一般程序之實例如下述。黏合劑分 本紙張尺度適用 -9- (CNS)A4#1；^( 210X 297&.) - · I- -I —1 -. I—J----------— II (請先閱讀背面之；&意事項再頁) 、11 ,% 537902 A7 B7 五、發明説明（ 散於山梨糖醇或甘油中，以高速度攪拌，分散液在該速度 擾拌5分鐘。水加入，生成之膠漿再攪拌15分鐘。乾燥掺 合之混合物分別由糖精鈉及苯甲酸鈉製備。若使用氟化 鋼，一氟鱗酸鋼，二氧化欽，或任何其他鹽，彼等在此階 段加入混合物中。然後混合物分散於膠漿中，在低速攪拌 1 0分鐘以形成膠凝。顏料加入，以攪:掉5分鐘混合。然後 膠凝移入Ross®混合器中。矽石加入，在部份眞空下（至少 720 mm Hg)混合1 5分鐘。調味劑加入，在完全眞空下混合 1 0分鐘，然後月桂基硫酸鈉加入，在完全眞空下混合1 5分 鐘。此時，取出樣品試驗，卸出批料以裝入管中。 下列實例係用以例示，並非限制本發明。 實例 比較具有變化量之％鹿角菜甞及C M C之調配物·。爲評估 黏合劑對於黏稍性，Cuban値，及安定性之影響，除％鹿 角菜甞及C M C黏合劑外之其他成份保持一致。表1顯示在 一組比較中保持一致之成份。 請 先 閱 讀 背 冬 I 事 項 再 頁 經濟部智慧財產局員工消費合作社印製 表1 .除黏合劑外之成份 成份 百分率 山梨糖醇70% 68.00 糖精 0.20 苯甲酸鈉 0.20 矽石（沉澱物） 7.00 矽石(磨擦劑） 11.00 -10- 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 537902 B7 五、發明説明（8 ) 經濟部智慧財產局員工消費合作社印製 調味劑 月桂基硫酸鈉 水 1.00 2.00 9.80-10.15 表2例示一些含有表1中所示成份及變化量之冗 及C M C之調配物。 表2 .代表性試驗調配物 鹿角菜苷 編號 %鹿角菜答 CMC t鹿角菜甞* 黃原膠 1 0.38 0.23 - - 2 0.32 0.13 - 睡 3 0.30 0.15 - - 4 0.34 0.21 - - 5 0.31 0.19 - - 6 0.50 0.30 - 睡 7 0.30 0.20 - - 8 0.31 0.29 - - 9 0.25 - 0.05 - 10 0.20 - 0.10 - 11 0.15 - 0.15 - 12 0.10 - 0.20 - 13 0.15 - 0.20 - 14 0.20 - 0.20 - 15 0.20 - 0.50 16 0.40 - - 0.40 (請先閲讀背面之注意事項再頁) -11 - 本纸張尺度適用中國國家標準（CNS ) A4規格（210'乂 297公釐） 五、 發明説明（9 17 18 19 20 21 22 0.45 0.35 0.50 0.70 0.50 0.75 經濟部智慧財產局員工消費合作社印製 * 6鹿角采甞含量爲約90%至100% 以L鹿角菜甞所製備之調配物含有0.03%氯化鉀。 驗結果 測里所製備之調配物之黏稠性，Cuban値，及物理安定 性。 调配物之黏稠性係使用質地分析器測量。質地分析器裝 < 一柱塞’其向下移動，接觸牙膏樣品。柱塞保留在樣品 上一疋時間，然後開始向上移動，攜帶一牙膏條。在柱塞 向上達到一特定高度或距離後，牙膏條將斷裂。當牙膏條 斷裂時立即停止試驗，柱塞移動之距離（毫米）爲黏稠性之 測量値。下列爲用以測量本發明黏稠性之詳細程序。2克 牙貧樣品放於質地分析器下板之中央。柱塞之力設定爲 2〇〇克，柱塞之前試驗（Pretest)速度設定爲1毫米/秒。前試 ’知速度爲減驗開始前柱塞向下移動之速度。柱塞之樣品抓 取時間設定爲2秒。使柱塞接觸置物板上之樣品，保留在 該處2秒，然後向上移動。後試驗時間設定爲1亳米/秒。 其爲柱塞上移動之速度。當牙膏條斷裂時立即停止試驗， -12 Μ氏張尺度適用中國國家標準（CNS ) A4規格（2!0x297公釐 537902 五、發明説明（10 測量柱塞移動之距離（毫米）。V. Description of the invention A7 B7 —In 1--Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs This invention is about a kind of gelatin. In particular, the present invention includes ... vegetable fen and fiber seed agent, containing two or two kinds: gel toothpaste, including a kind of glue, k, fen cellulose seed, such as carboxymethyl cellulose, ^ Compound t ' To provide—a kind of tooth with low viscosity and *] good consistency, maintain good physical stability, with a very low viscosity: Agent: For tooth V makers, the viscosity of toothpaste strips in history and today is An important consideration parameter. Mass production of soil Ququ _ & m > A typical person can use 80 minutes to fill the female minutes, the second heart: the filling line packaging toothpaste in a laminated tube. In order to comply with this mouthpiece, it is necessary to precisely cut off the tube for the strip. If the toothpaste is cut on the sealing part of the laminated tube, the sealing of the tube may fail, resulting in the tube: ^ tooth I overflowing from the tube may also cause the outside of the tube sealing area to become black, because p = During manufacture, open and darken tubes are removed. At Consumers ’sticky toothpaste, the toothpaste nozzle will have a tattered appearance during use. These problems are inherent to tails or sticky toothpaste. To avoid or reduce this problem, a toothpaste formulation that can be accurately cut off, that is, a toothpaste that is not sticky or smeared. Toothpaste generally contains a polishing or abrasive, wetting agent, thickening or binding agent, water, foaming agent, and flavoring agent. Wetting agents and water are also collectively referred to as vehicles. In addition, agents that provide therapeutic or cosmetic uses, such as fluorides and tartar control agents, can be incorporated. To provide a non-sticky toothpaste, the formulation must maintain other excellent physical properties that consumers are accustomed to. In order to satisfy consumers, these properties should provide toothpaste with an exciting taste, good cleaning effect, and easy to use.-This paper size applies the Chinese National Standard (CNS) M specification (210 > < 297 mm) III-IJ- J Yuben-(please read the paint notes on the back before finishing) thread washing, excellent taste, chemical and physical stability. In addition, these properties should provide toothpaste that is cost effective for consumers. The properties of the withering tooth compound depend on the binder, abrasive, wetting agent, water, and other ingredients of the formulation, and how these ingredients interact in the composite mixture. Generally speaking, the viscosity is determined by the type and amount of the binder and abrasive used in the toothpaste formulation. To a lesser extent, viscosity is also affected by the choice of wetting agent. Among the commonly used adhesives, for example, endocyl cellulose (CMC) is generally known to improve viscosity, and carrageenin reduces viscosity. Among the commonly used abrasives, silica is generally whiter and dicalcium maleate (DCP) can increase viscosity. Printed by the Consumer Affairs Agency of the Ministry of Economic Affairs and Intellectual Property, X Consumer Cooperatives. The general term "carrageen" is used to make similar polysaccharides derived from seagrass. All carrageenin contains repeating galactose units linked by alternating I-3 and α 1 4 glycoside bonds and is partially sulfated. The type of antlers is distinguished by the degree of sulfate. Carrageenin has repeating units D-galactose-4-sulfate-3,6-galactanhydride, providing a sulfate content of about 18 to 25%. L carrageenan has repeating units D_galactose_4_sulfate_3,6-anhydride-D-galactose-2-sulfate, providing a sulfate content of about 25 to 34%. λ Carrageenin has a repeating unit of 0_galactose_2_sulfate galactose-2,6-disulfate g, providing a content of g sulfate of about 30 to 40%. Carrageenin forms a denaturing gel. This gel has been reported to show excellent wiping, fragrance release, and rinseability. % And t-carrageenin is used as a binder for gelled toothpaste and it is also known to provide non-sticky toothpaste. However, U.S. Patent No. 4,604,280 describes a problem related to a composition made using carrageenin, when the composition is mechanically operated at a temperature lower than the gel-sol temperature ______- 5- This paper standard is applicable to the country of China Standard (CNS) A4 specification (210 X 297 mm) 537902 A7 --- -B7 V. Description of the invention (3) ^ When the composition is prepared, the viscosity or viscosity of the composition tends to decrease. For carrageen, the gel-sol temperature is between about 451 and 49. (: Within the range. Small operations below this temperature can sometimes cause a substantial reduction in viscosity. To compensate for this loss of viscosity, it is usually necessary to use an additional amount of antlers in the formulation. Therefore, antlers are usually Use at a concentration of 1% excess. In the toothpaste formulations, the type of carrageenin L,%, and several, L carrageen is generally better. Part of it is due to the difference in hardening effect. Relative For gelatin based on L-carrageenin, it has been reported that gelatin based on% carrageenin is easier to harden on a rack. Toothpaste hardened in this way is difficult to squeeze out of the tube. Compared to gelatin based on t-carrageenin Gelatin based on% Carrageenin may also have syneresis problems, that is, water may be separated by gelling. Toothpaste products are considered unacceptable if the phase separation is unstable. For these reasons, when Carrageenin is used as a gelled toothpaste When the adhesive is used, the form 6 is generally selected. One object of the present invention is to provide a non-sticky gel toothpaste, which contains% carrageenan as the main component of the adhesive, without the above-mentioned definiteness that is compatible with that of carrageen. ask Another object is to provide a toothpaste with a relatively low concentration of carrageenan. The invention has now found an adhesive containing carrageenin and a cellulose gum in a tooth taste formulation. 'Providing a toothpaste has a Surprising non-stickiness' shows good consistency and physical stability. The toothpaste can also be formulated to have excellent transparency. The weight percentage of the binder concentration in the formulation is in the range of about 0.30 to 0.8 0%. The adhesive The weight ratio of medium% carrageenan to cellulose gum is in the range of about 2 5: 7 5 to 7 5: 25. The preferred concentration of the binder is in the range of '—3 ~ —____________-6- i House Standard (CNS) A4 Specification (21 () X 297 ^ J ~ i '---- (Please read the back of I first: /-£ > Italy and then c. Install the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economy Printed ^ 7902 A7 B7 V. Description of the invention (4 ____ In the range of about 0M to 0 · 65, the better ratio of% antlers to cellulose gum (please read the precautions on the back first and then the page) 4 5 5 · 4 5 to 7 5: 2 5. The preferred cellulose gum is polymethylcellulose (CMC). DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a toothpaste, which contains an adhesive containing the carrageenin and a cellulose gum in a formulation. It is non-sticky, has good consistency, it is clear, and shows good physical properties. Stability. The present invention; overcomes the stickiness problems related to cellulose gum (domain methyl cellulose or CMC) and the syneresis and stability problems related to Euphora pallidum. It is obtained by mixing cellulose gum and% carrageenin. The adhesive can be used in standard gel toothpaste to provide a toothpaste that is non-sticky, stable for long periods of time in the separation of water and flavors, has good Cuban 値 (with good consistency), and has no appreciable hardening for a long time. Adhesives can be used at relatively low concentrations, which is an important factor for cost considerations ^. Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economics The present invention provides a toothpaste composition comprising an orally acceptable vehicle, a polishing agent, a surfactant, and a binder, the binder containing% antlers Diptera and a cellulose gum, the weight percentage of the binder concentration is in the range of about 0.30 to 0.80%, and the ratio of carrageenin to vitamine gum is in the range of about 25:75 to 75:25. Important features of the present invention are (a) the weight percentage of the binder concentration, and (b) the weight percentage of carrageenin to cellulose gum in the binder. The preferred concentration of the binder is in the range of about 45 to 0.65%. A more preferred concentration of the binder is between about 45 and 61%. The preferred ratio of% carrageenin to cellulose gum is in the range of about 5 5 ·· 4 5 to 7 5 ·· 2 5. A better ratio is between about 60 0 · 40 to 7 5: 2 5 and this paper size applies the Chinese National Standard (CNS) 8 4 specifications (210 > < 297 mm). Five 'invention description (5 A ? B7, the best ratio is between about 62:38 to 71:29. The cellulose gum in the binder can be in the form of a dry blending mixture co-processing mixture, any form is suitable. The mixture can be based on This technique is prepared by a generally known method. Cellulose gums that can be used in the present invention include those generally used as gum thickeners in toothpaste. Examples of the gums are ethyl cellulose, light propyl cellulose, and Effective cellulose-based cellulose. The term "cellulose gum" as used herein refers to cellulose gum or a combination thereof. The preferred gum is carboxymethyl cellulose. Tooth T generally includes a kind of vehicle, a kind of polishing Agent, a kind of adhesive, and a kind of surfactant and detergent. In addition, it can also provide agents for the treatment or granulation, such as enamel hardener, tartar control agent, whitening agent, and anti-fine 2 agents. One or more sweeteners and flavoring agents are optionally added to satisfy consumers. Right need, two Oxidation can also be added as a creamer or the vehicle for this toothpaste is an orally acceptable vehicle containing water and a wetting agent, such as a 3 to 6 carbon polyol, where each carbon is hydroxylated, and mixtures thereof Examples of wetting agents include glycerin, sorbitol, polyethylene glycol, polyoxyethylene glycol, mannitol, xylitol, and other sugar alcohols. Sorbitol and glycerol are preferred. Intellectual Property Bureau, Ministry of Economic Affairs Polishing agents or abrasives suitable for use in the toothpaste of the present invention printed by employee consumer cooperatives include finely divided water-insoluble powder materials, many of which are well known to those skilled in the art. These materials have polishing activity but are not excessively abrasive. Examples include two dances of gallic acid, tribasic acid, sodium squatrate, crystals, colloids, composite silicates, calcium carbonate, dibasic acid, magnesium phosphate, calcium pyroscale, bentonite, talc, Calcium Silicate, Calcium Aluminate's Oxide Ming, and Silica Dry Gelation. Better Abrasive -8- Sheet size is applicable to China National Standard (CNS) A4 (210X297 mm) 537902 A7 B7 V. Description of the invention (6 Consumer Co-operation of Intellectual Property Bureau, Ministry of Economic Affairs Printed as a gravel-based abrasive. The surfactants (cleaners) that can be used in the teeth of the present invention are generally emulsified or uniformly dispersed in toothpaste ingredients. Cleaners are generally preferably anionic or nonionic or Mixtures. Suitable shafts for anionic detergents include luna soda, fatty acid_glycerol sulphate, fatty acid sulphate, high calcined squaryl acid salt, sulkanyl sulfonate acetate, high olefin sulfonate, high fat Family brewed amines or low aliphatic amines «acids, high fluorenyl polyfluorenyl (3 to 100 alkoxy) sulfates, and fatty acid fertilizers. Examples of these anionic detergents include sodium lauryl sulfate, hydrogenated coconut 丨Fatty acid monosodium glycerol monosodium sulfate, sodium N-lauryl sodium carnitine, and sodium coconut oleic acid (cMMe). Suitable types of non-ionic cleaners include low alkylene oxide chains such as ethylene oxide and propylene oxide. Other substances added to the product include flavoring agents, Ruixiang hardeners, and antibacterial compounds. Examples of flavouring substances include sweeteners saccharin, flavors, spearmint, mint, wintergreen, 'Gary tree, lemon, and lime oil. Examples of the hardener include sodium monofluorophosphate, sodium fluoride, and tin fluoride. Examples of antibacterial agents are sodium benzoate trichlorosan and methyl or ethyl parasept. The toothpaste of the present invention can be prepared to be opaque or transparent. Without adding opalescent agent, the tooth taste has good transparency. Titanium dioxide is the preferred creamer and can be added to provide opaque toothpaste without affecting the physical characteristics of the formulation. An example of a general procedure for preparing the anaplastic formulation of the present invention at ambient temperature in a manner well known to those skilled in the art is as follows. Adhesive paper size applies -9- (CNS) A4 # 1; ^ (210X 297 &.)-· I- -I —1-. I—J ----------— II ( Please read the back of the page; & notes on the next page), 11,% 537902 A7 B7 5. Description of the invention (dispersed in sorbitol or glycerin, stir at high speed, and the dispersion is stirred at this speed for 5 minutes. Water Add the resulting paste and stir for 15 minutes. The dry blended mixture is prepared from sodium saccharin and sodium benzoate. If using fluorinated steel, monofluorinated steel, dioxin, or any other salt, they are here. Add to the mixture in stages. The mixture is then dispersed in the glue and stirred at low speed for 10 minutes to form a gel. Pigments are added to stir: 5 minutes to mix. Then the gel is transferred to a Ross® mixer. Silica is added in Mix for 15 minutes under partial emptying (at least 720 mm Hg). Add the flavoring agent, mix for 10 minutes under complete emptying, then add sodium lauryl sulfate, and mix for 15 minutes under complete emptying. At this time, remove the sample and test The batch is discharged for loading into a tube. The following examples are for illustration and are not a limitation on the present invention. Examples Compare the formulations of% Carrageenan and CMC with varying amounts. To evaluate the effect of the adhesive on adhesion, Cuban 値, and stability, other ingredients except% Carrageenan and CMC Adhesive were kept consistent .Table 1 shows the ingredients that are consistent in a set of comparisons. Please read the Winter I item first and then the page printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs. 1. The percentage of ingredients other than the binder is sorbitol 70% 68.00 Saccharin 0.20 Sodium benzoate 0.20 Silica (precipitate) 7.00 Silica (abrasive) 11.00 -10- This paper size applies to the Chinese National Standard (CNS) A4 specification (210X 297 mm) 537902 B7 V. Description of the invention (8) Economy The Ministry of Intellectual Property Bureau employee consumer cooperative printed the flavoring agent lauryl sulfate sodium water 1.00 2.00 9.80-10.15 Table 2 illustrates some of the formulations containing redundant and CMC ingredients and changes shown in Table 1. Table 2. Representative test formulation Carrageenin No.% Carrageenan CMC t Carrageenan * Xanthan Gum 1 0.38 0.23--2 0.32 0.13-Sleep 3 0.30 0.15--4 0.34 0.21--5 0.31 0.19--6 0.50 0.30-sleep 7 0.30 0.20--8 0.31 0.29--9 0.25-0.05-10 0.20-0.10-11 0.15-0.15-12 0.10-0.20-13 0.15-0.20-14 0.20-0.20-15 0.20 -0.50 16 0.40--0.40 (Please read the precautions on the back page) -11-The paper size is applicable to the Chinese National Standard (CNS) A4 specification (210 '） 297 mm) V. Description of the invention (9 17 18 19 20 21 22 0.45 0.35 0.50 0.70 0.50 0.75 Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs * 6 Antler harvesting content is about 90% to 100%. The preparation prepared from L. antlers contains 0.03% potassium chloride. Test results Test the viscosity, Cuban 値, and physical stability of the formulations prepared. The viscosity of the formulation was measured using a texture analyzer. The texture analyzer holds < a plunger ' which moves downward to contact the toothpaste sample. The plunger remains on the sample for a while, then begins to move up, carrying a toothpaste strip. After the plunger reaches a certain height or distance, the toothpaste strip will break. When the toothpaste strip breaks, the test is stopped immediately. The distance (mm) that the plunger moves is a measure of viscosity. The following is a detailed procedure for measuring the viscosity of the present invention. A 2 gram sample of anaemia was placed in the center of the lower plate of the texture analyzer. The force of the plunger was set to 200 grams, and the pretest speed of the plunger was set to 1 mm / sec. Before the test, the known speed is the speed at which the plunger moves downward before the start of the subtraction test. The sample grab time of the plunger was set to 2 seconds. Touch the plunger to the sample on the plate, leave it there for 2 seconds, and then move it up. The post-test time is set to 1 mm / s. It is the speed at which the plunger moves. When the toothpaste strip breaks, the test is immediately stopped. The -12 MM scale is applicable to the Chinese National Standard (CNS) A4 specification (2.0 × 297 mm 537902). 5. Description of the invention (10 Measure the distance (mm) of the plunger movement.
Cuban試驗値直接關斗 「如^ < a <黏性。Cuban試驗（亦稱s 「架（Rack)」試驗）中， Γ::柵，間隔逐漸增加。試驗結果以最大間隔數ΐ ^不表7^棒條間之最長距離，其支持牙膏 、、夂斷裂。该架爲約3〇〇毫米長及約1〇〇毫米寬。 不鏽鋼棒條以増加之距離間隔，棒條m間（間隔數 以3毫未開始，棒條間之距離以3毫米增加。因此，棒條2 及3間I距離為6毫米，棒條12及13間（間隔數目I”之炬 離爲39毫米。u及9_12之分數不可接受，3及8可接受， 4 - 7爲良好。 經濟部智慧財產局員工消費合作社印製 士足f生係由牙霄樣品裝入管中進行。管加蓋，在室溫及 在πχ:平放貯存12星期。在暴露12星期後，約5公分長之 牙霄條由管中擠出並試驗。然後管劃開，評估内容物之調 味劑及相分離（脱水收縮）。牙膏管頂部調味劑及水相之分 離可記爲「濕蓋」。調味劑分離之評分爲：1 =稍微，2 =中 等，及3二嚴重。安定性評分爲「不好」，「好」，及「良 好」。坪分爲Γ不好」表示樣品輕易顯示一些不欲性質， 如調味劑分離，脱水收縮，在管中極硬，或具有不可接受 之Cuban値。評分爲「好」表示樣品不分離，但可能有點 顆粒及缺乏良好光輝。評分爲「良好」表示樣品顯示無任 何分離現象，且樣品在一些微小細節優異，如良好質地或 無顆粒，且具有優異光輝或光澤。表3顯示上表1及2中所 述調配物之Cuban及安定性試驗之結果。 -13 本紙張尺度適用中國國家標準（CNS ) A4規格（210 X 297公釐） 537902 A7 B7 五、發明説明（11) 主3 .試驗結果_____ ~" — 安定1 生The Cuban test directly closes the bucket "such as ^ < a < viscosity. In the Cuban test (also known as the" Rack "test), Γ :: grid, the interval gradually increases. The test results are based on the maximum number of intervals 不 ^ not shown 7 ^ the longest distance between rods, which supports toothpaste, 夂 break. The stand is about 300 mm long and about 100 mm wide. Stainless steel rods are separated by a plus distance, between rods m (the number of intervals does not start with 3 millimeters, and the distance between rods increases by 3 mm. Therefore, the distance between rods 2 and 3 is 6 mm, rods 12 and The torch distance of 13 (interval number I ”is 39 mm. The scores of u and 9_12 are unacceptable, 3 and 8 are acceptable, and 4-7 are good. The dental samples were filled into tubes. The tubes were capped and stored flat at rt for 12 weeks at room temperature. After 12 weeks of exposure, approximately 5 cm long dental strips were extruded from the tubes and tested. Divide and evaluate the flavor and phase separation of the content (synthesis). The separation of the flavor and water phase on the top of the toothpaste tube can be recorded as a "wet cover". The score for the flavor separation is: 1 = slightly, 2 = medium And 3 and 2 are serious. The stability scores are "bad", "good", and "good". The grading of Γ is not good "means that the sample easily shows some undesired properties, such as flavoring agent separation, syneresis, etc. Extremely hard, or have unacceptable Cuban 値. A score of "Good" means that the sample is not divided , But may be a little grainy and lack good gloss. A score of "Good" indicates that the sample shows no separation, and the sample is excellent in some small details, such as good texture or no particles, and has excellent brightness or gloss. Table 3 shows the above table Results of Cuban and stability tests of the formulations described in 1 and 2. -13 This paper size applies to China National Standard (CNS) A4 specifications (210 X 297 mm) 537902 A7 B7 V. Description of the invention (11) Master 3 .Test Results _____ ~ "
編號 Cuban ^_5〇°C 1 5 良好 良好 2 5 良好 良好 3 3 良好 良好 4 5 好 好 5 5 好 好 6 9 濃稠 濃稠 7 5 略濃稠 略濃稠 8 5 好 好 9 10 好 碉味劑分離 10 9 好 調味劑分離 11 9 好 調味劑分離 12 5 好 調味劑分離 13 8 濃稠 好 14 9 濃稠 #1味劑分離 15 3 好 好 16 4 好 好 經濟部智慧財產局員工消費合作社印製 表3中編號1-8爲％鹿角菜苷/ CMC調配物，其中y鹿角 菜苷對CMC之比例在52 : 48至71 : 29範圍内。由表3可 見，％鹿角菜苷/ C M C調配物（編號1 - 8 )之Cuban値良好， 當欠鹿角菜甞濃度之重量百分率大於0.30%及小於〇.5〇 % 時。在較高濃度之％鹿角菜甞，長時間增稠劑亦成爲一個 問題。 __________-14 -- - ------—__ 本紙張尺度適用中國國家標準（CNS )八4規格（21〇x297公釐） 537902 A7 一 _____ 五、發明説明（12 ) ~" 表3中、.扁唬9 - 1 4爲嘗試由混合％及：鹿角菜苷製備適合 黏合劑I代表。由Cuban値及/或安定性結果可見，這些調 配物一般不可接受。表3中編號15爲嘗試由混合％鹿角菜 苷及黃原膠製備適合黏合劑不成功之代表。 除提供具有良好黏性及安定性之％鹿角菜甞基膠凝牙膏 外，另一目的爲提供非黏稠性之牙膏。本文中所用之術語 「非黏稠性」表具有低黏稠性（低於約2〇毫米）之牙膏。已 發現某^包含；c鹿角菜甞及CMC之黏合劑之膠凝牙膏顯示 令人驚奇之低黏稠性。爲提供具有低黏稠性之牙膏，黏合 劑濃度4較佳百分率在約〇·45至〇61%範圍内。在此範圍 内，兀鹿角菜苷對CMC之較佳比例在約62 : 3 8至71 : 29 範圍内。表4顯示本發明之一些代表性牙膏如何與其他牙 膏調配物比較，包括一些商業上廣泛使用之品牌。編號卜 22之調配物述於上表1及2中。 表4 .黏網性之比較 (請先閱讀背面之注意事項再本頁) •裝No. Cuban ^ _5〇 ° C 1 5 good good 2 5 good good 3 3 good good 4 5 good 5 5 good 6 9 thick thick 7 5 slightly thick slightly thick 8 5 good 9 10 good flavor separation 10 9 Good flavoring agent separation 11 9 Good flavoring agent separation 12 5 Good flavoring agent separation 13 8 Thickness good 14 9 Thickness # 1 Flavoring agent separation 15 3 Goodness 16 4 Goodness of the Ministry of Economic Affairs Intellectual Property Bureau Employee Consumption Cooperative Printed in Table 3 Numbers 1-8 are% carrageenin / CMC formulations, where the ratio of y carrageenin to CMC is in the range of 52:48 to 71:29. It can be seen from Table 3 that the Cuban 鹿 of the% carrageenin / CMCC formulation (No. 1-8) is good, when the weight percentage of the carrageenan concentration is greater than 0.30% and less than 0.5%. At higher concentrations of carrageen, long-term thickeners also become a problem. __________- 14----------__ This paper size is applicable to Chinese National Standard (CNS) 8 4 specifications (21 × 297 mm) 537902 A7 I _____ V. Description of the invention (12) ~ " Table 3,... 9-1 4 is an attempt to prepare a suitable binder I by mixing% and: carrageenin. It can be seen from Cuban (R) and / or stability results that these formulations are generally unacceptable. The number 15 in Table 3 represents the unsuccessful attempt to prepare a suitable adhesive from a mixture of carrageenin and xanthan gum. In addition to providing% carrageenan-based gel toothpaste with good stickiness and stability, another purpose is to provide non-sticky toothpaste. The term "non-sticky" as used herein refers to toothpastes with low viscosity (less than about 20 mm). It has been found that a gelled toothpaste containing a binder of c carrageenan and CMC shows a surprisingly low viscosity. In order to provide a toothpaste with low viscosity, a preferred percentage of the binder concentration 4 is in the range of about 0.45 to 0061%. Within this range, the preferred ratio of Caryophyll to CMC is in the range of about 62:38 to 71:29. Table 4 shows how some representative toothpastes of the present invention compare to other toothpaste formulations, including some brands that are widely used commercially. The formulation numbered 22 is described in Tables 1 and 2 above. Table 4. Comparison of stickiness (please read the precautions on the back before this page)
、1T 毫 稠 經濟部智慧財產局員工消費合作社印製 準 標 國 一國 I中 用 -適 一度 尺 一張 紙 I本 1 2 7 8 9 0 1 2 1112 2 2 祕 I釐 公 7.9.2.14 7 2. 2. ο. 6. 9. 2. 2 2 2 2 1 2 537902 A7 B7 五、發明説明（ 13 品牌A 18.7 品牌B 19.2 品牌C 18.2 品牌D 13.6 本發明之牙膏（在表4中以編號1及2表示）具有極低黏稠 性。這些牙膏之黏稠性實質上低於所試驗之四種商業上可 得牙膏之三種，本發明某些牙膏之黏稠性顯著低於所試驗 之商業上可得之最佳產品。低黏稠性係由使用相當少量之 兄鹿角菜苷於膠凝中之調配物達成，其顯示良好稠度及安 定性。 請 先 閱 讀· 背 面 之 注· 意 事 項 再 頁 經濟部智慧財產局員工消費合作社印製 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐）、 1T Printed by the Consumer Property Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs, China, China, China, China-Appropriately, a piece of paper 1 2 7 8 9 0 1 2 1112 2 2 2. 2. ο. 6. 9. 2. 2 2 2 2 1 2 537902 A7 B7 V. Description of the invention (13 Brand A 18.7 Brand B 19.2 Brand C 18.2 Brand D 13.6 The toothpaste of the present invention (numbered in Table 4 (Represented by 1 and 2) have extremely low viscosity. The viscosity of these toothpastes is substantially lower than that of three of the four commercially available toothpastes tested. The viscosity of certain toothpastes of the present invention is significantly lower than the commercially available test The best product obtained. Low viscosity is achieved by using a relatively small amount of the brother's carrageenin in the gel, which shows good consistency and stability. Please read · Notes on the back · Notes before the Ministry of Economic Affairs The paper size printed by the Intellectual Property Bureau employee consumer cooperative is applicable to the Chinese National Standard (CNS) A4 (210X297 mm)