516952 經濟部智慧財產局員工消費合作社印製 A7 B7 五、發明說明（1 ) 1. 發明之領域 本發明為一種可應用於校正核子醫學診斷儀器-加馬攝 影機探頭之録-57平面密封射源(57Co Flood Source)的新穎製 作方法’尤指鈷-57溶液均勻混合分佈在適當配方之環氧樹 脂/固化劑/有機溶劑介質中，倒入表面包覆一層Tefj〇n之長 方形水平固化模具，使其固化塑製成射源平板，下模後再放 置於ABS塑膠被覆板套内，予以密封。|古_57衰變時放出加 馬射線，主要能量為122keV及136.5keV，因與核子醫學診 斷常用鉻-99m(99mTc)同位素能量（l40keV)相近，且介於加馬 造影最佳範圍（100-300keV)，故常用於製作平面密封射源， 應用在加馬影像系統例行校正，可提高儀器臨床上擷取數據 之準確性及增進分子影像診斷判斷效果，為目前核子醫學診 斷儀器理想之校正射源。 2. 發明之背景 鈷-57半衰期為271.3d，衰變時經由原子核電子捕捉 (Electron Capture 100%)機制，放出低能量 X 射線(κα1，κα2, 〜6.4keV ; Kp 7.1keV)，並釋出能量為 14.4keV(9.5%)、 122keV(85.5%)及136keV(10.7%)之加馬射線，最後轉化為 穩定同位素鐵。藉由能量適中之録-57加馬射線的 穿透性，其平面密封射源可提供加馬攝影機探頭相關參數例 行校正【包括影像系統區域計測效率均一性（Camera’s uniformity in regional efficiency)、準直儀局部通徑傾斜度 (Collimator’s regional variations in channel tilt)、放大係數 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） ---------------I I--I ^--------- (請先閱讀背面之注意事項再填寫本頁) 516952 經濟部智慧財產局員工消費合作社印製 A7 B7 五、發明說明（2 ) (Gain coefficiency)及衰減校正（Attenuation correction)等】2, 3。鈷-57由於半衰期長，密封射源有效使用時間可長達一年 以上。 平面密封射源之製作，基本要求在於放射性同位素能 均勻分佈在平板型固化介質中，成型之射源平板必須厚度一 致且具有優良的化學穩定性、低的吸水率、固化收縮率小及 良好的機械強度。此外，介質成型加工宜操作容易，固化時 須無低分子物質析出引發放射性洩漏顧慮。傳統上， 液態薄板射源(Liquid sheet sources)曾廣泛應用於加馬攝影機 探頭校正，此種可再充填式液態射源之優點為活度分佈均勻 性高，惟半衰期太短(t1/2 = 6.02h)，須在使用當日自99Mo/99mTc 核種發生器淘洗出子核種，再經活度計測校正、混合震盡及 充填等製備步驟，容易造成液體外洩污染，極不方便。目前商 用固體始-57平面密封射源之製作一般採用模塑方法，使用線型熱塑 性環氧樹脂(Epoxy resins)為介質4,5，此類聚合物介質之商用產品種 類繁多，依分子量大小可從液態到固態，鈷-57平面密封射源之製作 應係使用黏稠度(Viscosity)適當之液態環氧樹脂，以便與射源溶液均 勻混合，易於模塑固化成型。由於環氧樹脂二端含有環氧基團 ()，其分子鏈中存在很多活性基團，在各種固化劑的作用 下，能交聯成網狀型結構，環氧樹脂因此可與固化劑混合後，顯現 出優良的物性，包括··⑴在低溫、低壓下可固化成型；（2)分子主鏈 中含有基和醚鏈，對金屬、塑膠、陶瓷、木材等具有優良的黏著 力；⑶固化收縮率低；（4)機械性及電絕緣性佳；⑶對一般化學藥品 具有良好的抗性；（6)可摻入不同種類添加劑改變其特性。始_57平面 ---------------------1--------- {請先閱讀背面之注意事項再填寫本頁> 3 經濟部智慧財產局員工消費合作社印製 516952 A7 … B7 五、發明說明（3 ) 密封射源之製作，除須選用適當黏稠度及固化反應速率適中之環氧 樹脂/固化劑為模塑介質材料外，尚須尋找與介質相容性良好且具有 水溶性之媒介溶劑，期能將數毫升的鈷_57溶液充分攪拌混合，均勻 分佈在介質中。由於模塑介質具有極強的黏著力，塑製方法、模具 設計及模具材質的選擇，亦將影響射源平板的製作品質及操作方便 性。 ’、 商用產品録-57平面密封射源一般係以聚合塑膠（如ABS) 或鋁質被覆板包裝密封6, 7，外型分為方型及圓型兩種，隨 產品品牌不同、外觀尺寸及有效面積（Active area)或有效直 徑略有差異。方型鈷-57平面密封射源之有效面積一般約在 46cmx36cm 或 61cmx42cm，射源活度範圍為 5mCi_2〇mCi; 圓型平面密封射源之有效直徑則在33cni_60cm，活度範圍為 2mCi-10mCi。經由電腦線上檢索，有關鈷·57固體校正射源 之專利國内無相關報告登錄，而發表在美國專利（US patent) 自1979年1月迄今僅有一篇類似8,且使用Unsaturated polyester resin MR11048 凝結劑/Td-isooctylamine 穩定劑/n-Butanol 有機溶劑/Methylethyl ketone peroxide 催化固化劑配 製，更無操作條件、製程設備及品質管制說明與要求。本發 明經由一系列的實驗測試，選擇黏稠度較低及固化反應速率 適中之Araldite Μ環氧樹脂/HY 956固化劑/PEG-200水溶性 有機溶劑等為模塑材料，其抗輻射線性質良好（1〇7 Rad)，在 適當配方及室溫下擾拌，始7溶液與介質可完全均勻混合。 射源平板塑製係利用可調整水平度表面包覆一層Teflon之固 化模具（Teflon coated)，固化成型後容易脫模，操作方便， 4 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） --------^---------^ (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 516952 A7 B7 五、發明說明（4 ) 製作品質佳。考量紹質被覆板易產生加馬散射（Gamma Scattering)，可能影響射源計測準確度，被覆板採用ABS塑 膠材質，以真空壓模方式製成，尺寸及有效面積則參考Du Pont Merck Pharmaceutical Cq·等相關商用產品規格設計，所 製得成品可用於國内各大醫院常用之加馬攝影機探頭校正。 3.發明之目的 從上述背景說明，本發明之目的在於： (1) 製作一種安全實用及操作方便之鈷-57平面密封射 源，提供核子醫學診斷儀器-加馬攝影機探頭校正使用，以 提高儀器臨床上擷取數據之準確性及增進分子影像診斷判斷 效果。 (2) 製作一種核子醫學診斷儀器-加馬攝影機探頭校正用 鈷-57平面密封射源，以落實研發技術本土化。所使用之加 馬同位素鈷-57係利用核能研究所中型迴旋加速器自行產 製，其核種半衰期長，密封射源使用期限可長達一年以上9。 (3) 製作一種核子醫學診斷儀器_加馬攝影機探頭校正用 姑-5 7平面挽封射源’選擇最佳介質材料及組成配方》能與 鈷-57完全均勻混合，黏稠度低及可塑性高，且具有良好的 抗輻射性質。 (4) 製作一種核子醫學診斷儀器_加馬攝影機探頭校正用 鈷-57用平面密封射源，設計製作可調整水平度之固化模具 (Teflon coated)，方便塑製成射源平板，容易下模且平面厚 度一致。 5 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） --------------------訂--------- (請先閱讀背面之注意事項再填寫本頁) 516952 經濟部智慧財產局員工消費合作社印製 A7 _____— B7 _ 五、發明說明（5 ) 兹配合圖示就本發明之核子醫學診斷儀器-加馬攝影機 探頭校正用姑-57平面密封射源裝置簡要說明如下： 第一圖（a )、（ b )為本發明鈷_57平面密封射源之構 造示意圖及實體，其製作程序概要為··取已知活度（6-i2mCi) 鈷-57溶液，先與適量水溶性有機溶劑PEG_2〇〇混勻後，加 入環氧樹脂（AralditeM)攪拌3〇分鐘，再加入固化劑（Ηγ 956) 攪拌18分鐘，然後倒入水平固化模具(Tefl〇n c〇ated)内塑製 成60cmLx41cmWx6mmT之射源平板（1 〇 )，下模後放置 於ABS被覆底板（2 0 )，週邊另以黏著劑膠著固定，再覆 蓋上層ABS被覆板（3 〇 )予以密封，ABS被覆板套（板厚 2mm)内外觀尺寸分別為 6icmLx42cmW><9mmH/66cmL x46cmW x2cmT。 第二圖（a )、（ b )為所製作之鈷_57平面密封射源貯 存與傳送用箱子（50)示意圖及實體，箱子（5〇)各邊 内概厚度為〇.5mm錯皮並墊有防震海棉層（圖中未示），底 部安裝拖行輪（5 0 )，外觀尺寸為 72cmLx22cmW><57cmH， 當裳載lOmCi姑-57平面密封射源後，估計其表面輻射劑量 率可小於30pSv/h，符合原子能法規射源安全運送管制標準 ($ 2mSv/h) 〇 兹以相關實施例說明本發明鈷-57平面密封射源之詳 細製作方法如下： 實施例1 :高純度鈷-57同位素之製備 麵-57平面密封射源之製作流程如第三圖所示，主要操 麥，我诋人沒過用中國國家標準（CNS)A4規格（21〇 x 297公釐 ------------A__w^--------訂--------- 華 (請先閲讀背面之注意事項再填寫本頁) 516952 經濟部智慧財產局員工消費合作社印製 A7 B7 五、發明說明（6 ) 作步驟（第三圖虛線以下）包括：高純度鈷_57同位素之製備 (6 0 )、介質材料選擇與組成配方摻合（7 0 )、塑製成型 與膠合密封（80)、品質管制（9〇)。本實驗共進行四次 照射試產始·57同位素，採用高豐度（99 90土0 04% Enriched) 鎳-58(58Ni)電鍍於銅基銀面制式靶體（1 〇 〇 )，於核能研究 所中型迴旋加速器（TR30/15)質子束能量（Ep)22-24MeV及電 流強度(I) 150-180μΑ條件下照射（1 1 〇 )適當時數，其淨 照射I為5000-8 000 μ Ah。照射免經靜置冷卻3_7週，俟一些 短半衰期核種儘量抑低後，以濃鹽酸浸泡隔夜或加熱溶解（1 2 0 ) ’再以陰離子交換樹脂Dowex 1 χ8 (200-400 mesh)裝填 於lcm())><5cmL玻璃管柱進行層析分離（1 3 〇 )。鎳因不吸 附經過清洗（1 3 2 )幾可全量洗出管外，加以回收（1 3 3 )重復使用，鈷_57則以1M HC1溶液淘洗（1 3 1 )，溶 液中核種活度與純度係使用Canberra GC2520 Coax Ge516952 Printed by the Consumers ’Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs A7 B7 V. Description of the Invention (1) 1. Field of the Invention The present invention is a kind of correction instrument for nuclear medicine diagnosis-Record of Gama camera probe-57 plane sealed radiation source (57Co Flood Source) a novel production method, especially the cobalt-57 solution is uniformly mixed and distributed in an appropriately formulated epoxy resin / curing agent / organic solvent medium, and poured into a rectangular horizontal curing mold coated with a layer of Tefjon. It is cured and molded into a source plate, and it is placed in an ABS plastic cover plate sleeve after being lowered and sealed. | Gamma_57 emits gamma rays during the decay, the main energy is 122keV and 136.5keV, because it is similar to the chromium-99m (99mTc) isotope energy (l40keV) commonly used in nuclear medicine diagnosis, and is within the optimal range of gamma imaging (100- 300keV), so it is often used to make flat sealed radioactive sources. It is used for routine calibration in Gama imaging system, which can improve the accuracy of the clinical data acquisition and the effect of molecular imaging diagnosis. It is an ideal calibration for current nuclear medicine diagnostic instruments. Radio source. 2. Background of the invention The half-life of cobalt-57 is 271.3d. During decay, it emits low-energy X-rays (κα1, κα2, ~ 6.4keV; Kp 7.1keV) and releases energy via the Electron Capture 100% mechanism. Gamma rays of 14.4 keV (9.5%), 122 keV (85.5%), and 136 keV (10.7%) were finally converted into stable isotope iron. With the energy-permeability of -57 gamma rays, its flat sealed source can provide routine calibration of gamma camera probe-related parameters [including Camera's uniformity in regional efficiency, Collimator's regional variations in channel tilt, magnification factor This paper size is applicable to China National Standard (CNS) A4 (210 X 297 mm) ------------- --I I--I ^ --------- (Please read the notes on the back before filling out this page) 516952 Printed by the Consumers ’Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs A7 B7 V. Invention Description (2) (Gain coefficiency) and attenuation correction (Attenuation correction), etc.] 2, 3. Cobalt-57 has a long half-life, and the sealed source can be used effectively for more than one year. For the production of flat sealed radioactive sources, the basic requirement is that the radioisotopes can be evenly distributed in the flat-type curing medium. The formed radioactive source plates must be uniform in thickness and have excellent chemical stability, low water absorption, small curing shrinkage, and good Mechanical strength. In addition, the medium forming process should be easy to operate, and there must be no concern about radioactive leakage caused by the precipitation of low molecular substances during curing. Traditionally, liquid sheet sources have been widely used for calibration of Gama camera probes. The advantage of this refillable liquid source is high uniformity of activity distribution, but the half-life is too short (t1 / 2 = 6.02h), it is necessary to eluate the sub-nuclear seeds from the 99Mo / 99mTc nuclear seed generator on the day of use, and then undergo the preparation steps such as activity measurement correction, mixed shaking out and filling, which are likely to cause liquid leakage and pollution, which is extremely inconvenient. At present, the production of commercial solid starter-57 plane sealed radiation sources generally adopts the molding method, using linear thermoplastic epoxy resins (Epoxy resins) as the media 4,5. There are many types of commercial products of such polymer media, depending on the molecular weight. From liquid to solid, the production of Cobalt-57 flat sealed shot source should use liquid epoxy resin with appropriate viscosity (Viscosity), so as to be evenly mixed with the shot source solution, and easy to be molded and solidified. Since the epoxy resin contains epoxy groups at both ends, there are many active groups in its molecular chain. Under the action of various curing agents, it can be crosslinked to form a network structure, so the epoxy resin can be mixed with the curing agent. Later, it showed excellent physical properties, including: · ⑴ can be cured at low temperature and low pressure; (2) the molecular main chain contains groups and ether chains, and has excellent adhesion to metals, plastics, ceramics, wood, etc .; ⑶ Low curing shrinkage; (4) Good mechanical and electrical insulation; (3) Good resistance to general chemicals; (6) Different types of additives can be added to change its characteristics. Start _57 plane --------------------- 1 --------- {Please read the precautions on the back before filling in this page> 3 Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs 516952 A7… B7 V. Description of the invention (3) For the production of sealed radioactive sources, except for the use of epoxy resin / curing agent with suitable viscosity and moderate curing reaction rate as the molding medium material In addition, it is necessary to find a medium solvent that has good compatibility with the medium and has water solubility. In the future, a few milliliters of the cobalt_57 solution can be fully stirred and mixed to be evenly distributed in the medium. Due to the strong adhesion of the molding medium, the choice of molding method, mold design, and mold material will also affect the production quality and ease of operation of the source plate. ', Commercial product record -57 flat sealed radioactive source is generally sealed with polymer plastic (such as ABS) or aluminum clad board 6, 7, the appearance is divided into square and round type, depending on the product brand, appearance size And the active area (Active area) or effective diameter is slightly different. The effective area of the square cobalt-57 plane sealed radioactive source is generally about 46cmx36cm or 61cmx42cm, the active range of the radioactive source is 5mCi_2〇mCi; the effective diameter of the round flat sealed radioactive source is 33cni_60cm, and the active range is 2mCi-10mCi. Through the online search of the computer, there is no related report on the patent of the cobalt · 57 solid correction radioactive source in the country, and it has been published in the United States patent (US patent) since January 1979. Only one article is similar to 8 and uses Unsaturated polyester resin MR11048 to coagulate. Agent / Td-isooctylamine stabilizer / n-Butanol organic solvent / Methylethyl ketone peroxide Preparation of catalytic curing agent, without operating conditions, process equipment and quality control instructions and requirements. Through a series of experimental tests, the present invention selects Araldite M epoxy resin / HY 956 curing agent / PEG-200 water-soluble organic solvent as a molding material with a low viscosity and a moderate curing reaction rate, and has good radiation resistance properties. (107 Rad). Stir and stir at proper temperature and room temperature. The 7 solution and the medium can be completely and uniformly mixed. The source flat plastic molding system uses an adjustable level surface to cover a layer of Teflon curing mold (Teflon coated), which is easy to demould after curing and easy to operate. 4 This paper size applies to China National Standard (CNS) A4 specification (210 X 297 mm) -------- ^ --------- ^ (Please read the notes on the back before filling out this page) Printed by the Employees' Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 516952 A7 B7 5 2. Description of the invention (4) The production quality is good. Considering that the quality of the clad plate is prone to Gamma Scattering, which may affect the accuracy of the measurement of the source, the clad plate is made of ABS plastic and made by vacuum compression molding. For the size and effective area, refer to Du Pont Merck Pharmaceutical Cq · And other related commercial product specifications design, the finished product can be used in domestic major hospitals commonly used Gama camera probe calibration. 3. Purpose of the Invention From the above background description, the purpose of the present invention is to: (1) make a safe, practical and easy-to-operate cobalt-57 flat sealed radioactive source, and provide a nuclear medical diagnostic instrument-calibration camera probe to improve the use of The accuracy of the data acquired by the instrument clinically and the effect of molecular imaging diagnosis. (2) Manufacture a nuclear medical diagnostic instrument-Cobalt-57 flat sealed radioactive source for calibration of Gama camera probes to implement localization of R & D technology. The Canadian-Isotope cobalt-57 used is produced by a medium-sized cyclotron of the Institute of Nuclear Energy. Its nuclear species has a long half-life and the life of sealed radioactive sources can be as long as more than one year9. (3) Manufacture a nuclear medical diagnostic instrument _ Gama camera probe calibration-5 7 plane unsealing radioactive source 'Select the best medium material and composition formula' Can be completely and uniformly mixed with cobalt-57, low viscosity and high plasticity , And has good anti-radiation properties. (4) Manufacture a nuclear medicine diagnostic instrument _ Gama camera probe calibration cobalt-57 plane sealing radiation source, design and manufacture a leveling-adjustable curing mold (Teflon coated), easy to mold into a radiation source plate, easy to mold And the plane thickness is the same. 5 This paper size is applicable to China National Standard (CNS) A4 (210 X 297 mm) -------------------- Order --------- (Please read the precautions on the back before filling this page) 516952 Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs A7 _____ — B7 _ V. Description of the Invention (5) The nuclear medicine diagnostic instrument of the present invention is added with the illustration A brief description of the Gu-57 plane sealed source device for horse camera probe calibration is as follows: The first diagrams (a) and (b) are the structural diagram and entity of the cobalt_57 plane sealed source of the present invention, and the outline of the production process is ... Take a known activity (6-i2mCi) cobalt-57 solution, mix it with an appropriate amount of water-soluble organic solvent PEG_2, add epoxy resin (AralditeM) and stir for 30 minutes, and then add a curing agent (Ηγ 956) and stir 18 minutes, then poured into a horizontal curing mold (Tefloncated) into a 60cmLx41cmWx6mmT injection source plate (10), placed in the ABS-covered bottom plate (20) after the lower mold, and fixed around with an adhesive , And then cover the upper layer of ABS cover plate (30) to seal, ABS cover plate sleeve (plate thickness 2mm) internal appearance ruler Respectively 6icmLx42cmW > < 9mmH / 66cmL x46cmW x2cmT. The second picture (a) and (b) are the schematic diagram and the entity of the manufactured cobalt_57 plane sealed source storage and transmission box (50). The approximate thickness of each side of the box (50) is 0.5mm. Shock-resistant sponge layer (not shown in the figure), a tow wheel (50) is installed at the bottom, and the external dimensions are 72cmLx22cmW > < 57cmH. When the 10mCigu-57 plane sealed radiation source is mounted, the surface radiation dose is estimated. The rate can be less than 30 pSv / h, which complies with the atomic energy regulations for the safe transportation of radio sources ($ 2mSv / h). The detailed production method of the cobalt-57 flat sealed radio source according to the present invention is described in the following examples: Example 1: High purity The production process of the cobalt-57 isotope preparation surface-57 plane sealed radioactive source is shown in the third figure. It mainly handles wheat. We have never used the Chinese National Standard (CNS) A4 specification (21〇x 297 mm-- ---------- A__w ^ -------- Order --------- Hua (Please read the notes on the back before filling this page) 516952 Intellectual Property Bureau, Ministry of Economic Affairs Printed by employee consumer cooperative A7 B7 V. Description of invention (6) The working steps (below the dashed line in the third figure) include: preparation of high-purity cobalt _57 isotope (6 0 ), Medium material selection and composition formulation blending (70), plastic molding and gluing sealing (80), quality control (90). This experiment was carried out four times in total, trial production of 57 isotopes, using Gaofeng Degree (99 90 soil 0 04% Enriched) nickel-58 (58Ni) electroplated on a copper-based silver surface target (100), proton beam energy (Ep) 22 in a medium-sized cyclotron (TR30 / 15) of the Nuclear Energy Research Institute -24MeV and current intensity (I) 150-180μA irradiation (1 1 〇) for an appropriate number of hours, its net irradiation I is 5000-8 000 μ Ah. Irradiation is allowed to stand for 3-7 weeks without cooling, and some short half-life nuclear species should be tried as far as possible After suppression, immerse in concentrated hydrochloric acid overnight or dissolve by heating (1 2 0) 'and then fill it with anion exchange resin Dowex 1 χ8 (200-400 mesh) in lcm ()) > < 5cmL glass column for chromatographic separation. (1 3 0). Because nickel is not adsorbed, it can be washed (1 3 2) out of the tube and washed out of the tube. It can be recycled (1 3 3) and reused. Cobalt_57 is washed with 1M HC1 solution (1 3 1). The nuclear species activity in the solution Canberra GC2520 Coax Ge and purity
Detecto卜4096多頻道脈高分析儀(MCA)分析。 照射產率如附表一，顯示利用Enriched 58Ni電鍍靶經照 射核反應58Ni(p, 2p)鈷-57及冷卻溶解後，溶解液中所量測 之钻-57活度校正至停止照射時間（End of bombardment, EOB)，可得平均產率為ΐ2.〇±1.7μ(^/μΑ1ι。經陰離子交換分 離後，鈷-57回收率約達98%，核種純度>99.7%，成品液中 主要核種雜質為56Co，來自58Ni(p, ρ2η)或58Ni(p, 2ρη)核反 應，另一核種雜質58Co則來自58Ni(n，ρ)核反應，因量極小 可忽略不計。從四次試產實驗顯示，在Ep = 22MeV時上述 核種雜質產生量相對於鈷-57之活度百分率分別為56Co 0.15· 7 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） --------------------訂--------- (請先閱讀背面之注意事項再填寫本頁) 516952 經濟部智慧財產局員工消費合作社印制衣 A7 B7 五、發明說明（7 ) 0.26%及 58Co 0.04-0.07% ;而在 Ep = 24MeV 時 56Co/57Co 比 值明顯增加為 0.64%。由於 56Co(t1/2=77d)及 58Co(t1/2 = 71d) 半衰期較57Co(t1/2 = 271.3d)為短，隨靜置時間之延長，此等 核種雜質含量相對降低很多，有利於提升鈷-57成品溶液之 核種純度。檢討鈷-57平均產率之誤差來源，主要包括射束 能量與電流強度控制、58Ni電鍍在靶體分佈均勻性、有效核 反應截面積差異、取樣與稀釋操作及儀器分析等相關因素。 綜合上述實驗結果，選擇質子束能量在20MeV<EpS 22MeV及電流強度（I)為150-180μΑ條件下照射適當時間， 經冷卻、化學分離及射源製作程序約2_3個月後，計算鈷-57 核種純度可達到平面密封射源之製作規格標準（>99.8%)。 表一、鈷-57同位素之製備 實驗 Enriched 99.9% 58Ni 靶重(g) 照射> ί丨条件 溶解液 57Co 活度，mCi (距EOB時間，d) 57Co EOB 產率 (μΟ/μΑ1ι) 質子束能量 (MeV) 淨照射量 (μΜ) 1 0.183 24 1050 10.7(21) 10.8 2 0.216 22 6000 53.4 (33) 9.7 3 0.189 22 6711 88.1 (25) 14.0 4 0.223 22 6072 70.0 (49) 13.3 平均產率 12.0±1.7μΟ/μΜ 實施例2 :介質材料選擇與組成配方摻合 本實驗先後使用三種環氧樹脂/固化劑及不同的水溶性 有機溶劑，測試在不同體積比配方下相關介質材料之攪拌摻 合情形，包括黏稠度、固化反應速率、水溶性有機溶劑相容 性及混勻後氣泡產生與分佈，並以塗敷與模塑兩種方式製作 射源平板，以瞭解成型加工操作之方便性、固化時有無低分 8 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） --------------------訂---------線 (請先閱讀背面之注意事項再填寫本頁) 516952 經濟部智慧財產局員工消費合作社印製 A7 B7 五、發明說明（8 ) 子物質析出、固化板厚度平整性及鈷-57是否均勻分佈於介 質中。 實驗結果綜合如附表二，顯示採用環氧樹脂AW 136H/ 固化劑HY 991/酒精或丙酮溶劑在適當配方下攪拌，其固化 反應速率快，成型加工操作不便，故不適合作為介質材料； 而選擇環氧樹脂AW 106/固化劑HV 953U/酒精或丙酮溶劑 在適當體積比混合攪拌15分鐘，塗敷於ABS被覆底板，利 用水平振盪床振動3分鐘，顯示酒精或丙酮皆未能有效氣化 釋出，而且連同攪拌引進之空氣氣泡會遍佈於固化平板上 層，導致表面不平整。利用水溶性有機溶劑PEG-200(P〇lyethylene glycol 200)為鈷-57之媒介溶劑，雖可與前 兩種介質混合互溶，並可降低介質塗料黏稠度，惟以 900/300/300體積比混合塗敷後所得之固化平板，會呈現細 小空氣氣泡均勻分佈於上層，表面接觸雖似平滑但有微量 PEG-200析出；若減少PEG-200用量則黏稠度會增加，仍不 利於塗敷操作，其固化平板鈷_57活度分佈均勻性經掃描偵 測’相對標準偏差為1.88-2.1%。造成此種偏差之主要原因， 係由於真空壓模法所製作之ABS被覆底板，其底面水平度 不易達到精準一致。當實驗採用環氧樹脂Araldite M/固化劑 HY 956/水溶性有機溶劑PEG-200為介質材料時，由於其密 度(g/cm3)分別為1.15、丨^及M2，顯示混合相容性良好且 黏稠度低，品質上適合以模塑方式製作射源平板。有關摻合 與成型加工操作步驟，係將環氧樹脂(Araldite M，125〇ml)與 鈷·57 >谷液（取2-3ml鈷-57成品液溶於1〇〇ml pEG-2〇〇)混 9 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公复） ---I------I --------訂--------- (請先閱讀背面之注意事項再填寫本頁) 516952 A7Detecto 4096 multi-channel pulse height analyzer (MCA) analysis. The irradiation yield is shown in Table 1. It shows that the Enriched 58Ni plating target was used to irradiate the nuclear reaction 58Ni (p, 2p) cobalt-57 and dissolve after cooling. The activity of the drill-57 measured in the solution was corrected to the stop irradiation time (End of bombardment (EOB), the average yield is ΐ2.0 ± 1.7μ (^ / μΑ1ι. After anion exchange separation, the recovery of cobalt-57 is about 98%, and the purity of nuclear species is> 99.7%. The nuclear impurity is 56Co, which comes from the 58Ni (p, ρ2η) or 58Ni (p, 2ρη) nuclear reaction, and the other nuclear impurity, 58Co, comes from the 58Ni (n, ρ) nuclear reaction, which is negligible due to the extremely small amount. From four trial production experiments, When Ep = 22MeV, the activity percentages of the above-mentioned nuclear impurities relative to cobalt-57 are 56Co 0.15 · 7 respectively. This paper size applies the Chinese National Standard (CNS) A4 specification (210 X 297 mm) ----- --------------- Order --------- (Please read the precautions on the back before filling out this page) 516952 Employees' Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs print clothing A7 B7 V. Description of the invention (7) 0.26% and 58Co 0.04-0.07%; and the 56Co / 57Co ratio increased significantly to 0.64% when Ep = 24MeV. Since 56 The half-life of Co (t1 / 2 = 77d) and 58Co (t1 / 2 = 71d) is shorter than 57Co (t1 / 2 = 271.3d). With the prolonged standing time, the content of these nuclear impurities is relatively reduced, which is conducive to improvement. Nuclear purity of the finished cobalt-57 solution. Review the sources of error in the average yield of cobalt-57, including the control of beam energy and current intensity, the uniformity of the distribution of 58Ni plating on the target, the difference in effective nuclear reaction cross-sectional area, sampling and dilution operations, and Relevant factors such as instrument analysis. Based on the above experimental results, the proton beam energy was selected under the conditions of 20MeV < EpS 22MeV and current intensity (I) of 150-180μA for an appropriate period of time, after cooling, chemical separation, and source production process for about 2_3 months After that, it was calculated that the purity of the cobalt-57 nucleus could reach the production specification standard of the plane sealed source (> 99.8%). Table I. Preparation experiment of cobalt-57 isotope Enriched 99.9% 58Ni Target weight (g) Irradiation > ί 丨 Conditions Dissolved 57Co activity, mCi (time to EOB, d) 57Co EOB yield (μΟ / μΑ1ι) proton beam energy (MeV) net exposure (μM) 1 0.183 24 1050 10.7 (21) 10.8 2 0.216 22 6000 53.4 ( 33) 9.7 3 0.189 22 6711 88.1 (25) 14.0 4 0.223 22 6072 70.0 (49) 13.3 Average yield 12.0 ± 1.7 μO / μM Example 2: Selection of media materials and blending of formulations This experiment used three epoxy resins / curing agents and different water solubility. Organic solvents, test the mixing and mixing of related media materials under different volume ratio formulas, including viscosity, curing reaction rate, compatibility of water-soluble organic solvents, and bubble generation and distribution after mixing, and apply coating and molding Make the source plate in two ways to understand the convenience of the molding process and whether there is a low score when curing. 8 The paper size is applicable to the Chinese National Standard (CNS) A4 specification (210 X 297 mm) -------- ------------ Order --------- line (please read the precautions on the back before filling this page) 516952 Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs A7 B7 5 2. Description of the invention (8) Precipitation of sub-materials, thickness flatness of the solidified plate, and whether cobalt-57 is evenly distributed in the medium. The comprehensive experimental results are shown in Table 2. It shows that the epoxy resin AW 136H / curing agent HY 991 / alcohol or acetone solvent is stirred under the proper formula, the curing reaction rate is fast, and the molding processing operation is inconvenient, so it is not suitable as a dielectric material; Epoxy resin AW 106 / curing agent HV 953U / alcohol or acetone solvent was mixed and stirred at an appropriate volume ratio for 15 minutes, coated on the ABS coated bottom plate, and shaken for 3 minutes on a horizontal shaking bed, showing that neither alcohol nor acetone could be effectively vaporized and released. Out, and the air bubbles introduced along with the stirring will spread throughout the upper layer of the solidified flat plate, resulting in uneven surface. The use of water-soluble organic solvent PEG-200 (Polyethylene glycol 200) as the medium solvent of cobalt-57, although it can be mixed and miscible with the first two mediums, and can reduce the viscosity of the medium coating, but the volume ratio of 900/300/300 The solidified flat plate obtained after mixing and coating will show fine air bubbles evenly distributed on the upper layer. Although the surface contact appears to be smooth, a small amount of PEG-200 will be precipitated. If the amount of PEG-200 is reduced, the viscosity will increase, which is not conducive to the coating operation. The relative standard deviation of the activity distribution uniformity of the solidified flat cobalt _57 after scanning detection was 1.88-2.1%. The main reason for this deviation is that the bottom surface level of the ABS-coated bottom plate produced by the vacuum compression molding method is difficult to achieve precise consistency. When the epoxy resin Araldite M / curing agent HY 956 / water-soluble organic solvent PEG-200 was used as the dielectric material, the density (g / cm3) was 1.15, ^^, and M2, showing good mixing compatibility and It has low viscosity and is suitable for making the source plate by molding. For the blending and molding operation steps, epoxy resin (Araldite M, 1250 ml) and cobalt · 57 > grain solution (take 2-3 ml of cobalt-57 finished solution to 100 ml of pEG-2. 〇) Mixed 9 This paper size applies Chinese National Standard (CNS) A4 specification (210 X 297 public copy) --- I ------ I -------- Order ------- -(Please read the notes on the back before filling this page) 516952 A7
經濟部智慧財產局員工消費合作社印製 五、發明說明（9 ) 合’以電動攪拌器攪拌30分鐘，然後靜置3_4小時，俟空 氣氣泡盡量釋出及料液完全澄清後，再摻人固化劑(Ηγ 956, 250ml)授拌18分鐘，最後倒人水平固化模具中（㈣⑽e〇ated) 靜置固化’約-週後下模，操作十分簡便。製成之射源平板 品質呈透明淡黃色且不含氣泡，表面平直厚度_致，無任何 低分子物質析出現象。鈷_57活度分佈均勻性經掃描偵測， 顯示已達到商用產品規格（詳如實施例3與4)。 表-、壞氧樹脂/固化劑/有機溶劑介質材料在不同配方下掺合及固化情形 環氧 樹脂 固化劑 有機 溶劑 混合體 積比 (單位ml) Ί---- 攪拌時間 I 黏度 摻合與加工成型現象 AW 136H ΗΥ 991 酒精或 丙酮 750/ 250/ 200 15分鐘 稍稠 摻合後呈灰色稍稠液態， 固化反應速率快，塗敷操 作較不方便。 AW 106 HV 953U 酒精或 丙酮 PEG-200 900/ 300/ 300 900/ 300/ 300 20分鐘 20分鐘 稍稠 適中 混合攪拌15分鐘後塗敷 於ABS被覆底板，利用 水平振盈床振動3分鐘， 放置於水平台靜置，約需 三天完全固化，呈半透明 淡黃色，氣泡遍佈於上 層，表面不平整。 PEG-200與環氧樹脂可混 合相容兼具稀釋作用，攪 拌15分鐘後塗敷於abs 被覆板，在水平台上靜 置’約需五天完全固化， 有細小氣泡均勻分佈於上 層，表面平滑但有微量 PEG-200析出，57c〇活度 分佈均勻性為1.88-2.1% r.s.d. 〇 Μ ΗΥ 956 PEG-200 1250/ 250/ 100 1 25分鐘 _, 稀 57Co溶液先溶於PEG_2〇〇， 再與環氧樹脂勝30分鐘 及靜置4小時，俟氣泡盡釋 10 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） --------------------^-------- (請先閱讀背面之注意事項再填寫本頁) 516952 經濟部智慧財產局員工消費合作社印製 A7 B7 五、發明說明（10) |及料液完&登清後，摻入固 化劑擾拌18分鐘，再倒入 水平固似莫^{Teflon coated) 靜置，約一週後完全固化， 呈透明淡黃色不含氣泡，表 面平直厚度一致，無任何低 分子物質析出，57Co活度分 _ ___ 丨佈均勻性為 0.59~0.7% r.s.d.。 實施例3 :塑製成型與膠合密封 平面密封射源之製作基本考量因素，為放射性同位素能 均勻固著在平板型固化介質中，且密閉性良好，無虞放射性 物質洩漏。有關鈷-57能均勻固著在Araldite Μ環氧樹脂上 之化學反應機制，研判可能為57C〇Cl2水溶液中之c〇2+離子 先與PEG-200[HO(C2H4O)nH]溶劑上羥基(-0H)中之氫原子產 生取代反應，而PEG-200另一羥基之氫原子再與Araldite Μ 環氧樹脂上醚鏈（-R-0-R)中之氧原子上成對電子形成氫鍵結 合。實驗証明塑製成型之射源平板，經以乾濾紙擦試射源平 板表面，濾紙活度計測為背景值，顯示鈷-57可穩定固著於 介質内。塑製射源平板之固化模具分為兩部份，上模為框型 不銹鋼材質，内外尺寸為60cmLx41cmW x3CmT/66cmLx47CmWx3Cmin下模為平板型不銹鋼材質， 外部尺寸為66cmLx47CmWx3cmT。不銹鋼體先經由粗胚研 磨後，整體外表再包覆-層Tefl⑽材f，然後經表面精細研 磨加工，其水平厚度精準度可達到〇 〇3麵。而模塑介質材 料靜置固化所使用之移動式精密平台係以13咖厚花岗石製 作成型，其平面精準度為〇_〇 〇〇8_，石板置於雙速腳踏式 11 本紙張尺度適用中國國家標準(CNS)A4規格（2_1〇 x 297公董） — — — — — — — — — — — · I I I I I I I > — — — — — — — — (請先閱讀背面之注意事項再填寫本頁) 516952 A7 經濟部智慧財產局員工消費合作社印製 Β7 五、發明說明（11) 油壓升降台車上，平台並設有校正水平面用之微調腳座4 只，操作穩定方便。塑製前須先以數字型水平儀仔細調整平 台水平面，使整面水平度達到0.00-0.02。，再將固化模具置 於平台上，並核驗模板水平度，然後依照實施例2塑製介質 材料配方摻合與操作步驟，倒入模具中固化成型，詳如附表 二所示。 請參閱第一圖所示，固化成型之射源平板（1 〇 )無收 縮現象，下模後放置於ABS被覆底板（2 0 )内，其週邊5mm 寬之空隙另以環氧樹脂黏著劑（AW 1〇6/HV 953u，混合體積 比為10:8)填注將射源平板（} 〇)固定，最後以ABS膠均 勻塗敷於ABS被覆板（3 〇 )之四邊溝槽，與ABS被覆底 板（2 0 )邊緣膠合密封，即得鈷_57平面密封射源。 被覆板（3 0 )(四周相對兩側膠合處，寬度分別為25cm 及2cm可複設把手，以避免直接觸及平面密封射源。 請參閱第二圖所示，射源傳送箱箱子（4 〇 )之箱底分 χΛ有4 〃、小型拖行輪（5 Q )，箱前並裝置2只特製扣鎖（4 1)相頂附有手提式把手（圖中未示），於前後再裝設拉行 把手（4 2 )各1只，以方便平面密封射源取出、存放盥傳 送’箱體各邊内襯皆裝置厚度為。5麵財及海棉整了足 夠達到輻射防護安全之需求。 實施例4 :品質管制 為確保始-57平面密封射源製作品質之穩定性及安全 性，相關品質管制極為重要。本發明已成功製作四個鈷 ------------Ψ------- —訂--------- 線· (請先閱讀背面之注意事項再填寫本頁) 12 516952 經濟部智慧財產局員工消費合作社印製 A7 B7 五、發明說明（12) 平面密封射源（完成製作時之活度分別為215.7、241.2、236.4 及230.9MBq)，分別依據標準檢驗方法ANSIStandaΓdN542· 1977, Appendix A Leak Test Methods 完成品管檢驗，相關操 作與測試結果說明如下： (1) 表面擦拭測試(wiPe smear test):以乾濾紙擦拭固 化成型之介質表面及沾濕濾紙擦試鈷-57平面密封射源ABS 被覆板套表面，分別利用Eberline BC-4計數器計測（效率 35%)，結果顯示濾紙試樣活度皆為背景值（2.OBq)，遠低於 法規值185Bq(5nCi)，亦即所製作之平面密封射源無虞放射 性洩漏污染顧慮。 (2) 活度分佈均勻性測試··製作射源平板支架及固定夾， 將製作之鈷-57平面密封射源垂直固定於Nal(Tl)偵檢器準直 儀前（紹?套厚度5cm，孔徑12mm，孔深20mm)，於距離射源 表面2mm及離開面板長邊緣5公分及寬邊緣4公分，以電 腦連接偵檢系統及應用軟體程式自動控制掃描使用區域 (Useful region)。貞檢器計測能量範圍（Energy window)設定 100-150keV，掃描移動由下而上及由左而右依序彳貞檢，每一 偵測點位移距離1公分，計測時間10秒，合計使用區域偵 測點約1734。以試製產品活度為230.9MBq(6.24mCi)之鈷-57 平面密封射源為例，其活度分佈均勻性測試結果如第四圖所 示’顯示鈷-57在有效使用範圍之活度分佈相對標準偏差 (Relative standard deviation)為土0.59〇/〇，驗証已達到商用產品 規格之最大相對標準偏差為±1%的嚴格要求。 上述相對標準偏差亦可稱為變動係數（Coefficient of 13 本紙張尺度適用中國國豕標準（CNS)A4規格（210 χ 297公爱） --------------------^--------- (請先閱讀背面之注意事項再填寫本頁) 516952 A7 五 發明說明U3) vanatum) ’係以下列公式設計成電腦軟體 果’並_色區分不同的相對平均計測值偏差^算測試結 製活度分佈掃插圖，請參閱第四圖所示。自動繪 r.s.(Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs. 5. Description of the invention (9) Mix with an electric stirrer for 30 minutes, and then let it stand for 3-4 hours. The air bubbles should be released as far as possible and the material liquid should be completely clarified, and then mixed and solidified. The agent (Ηγ 956, 250ml) was mixed for 18 minutes, and finally poured into a horizontal curing mold (㈣⑽e〇ated) and allowed to stand for curing for about-weeks, and the mold was lowered, and the operation was very simple. The quality of the produced source plate is transparent light yellow without bubbles, and the surface is flat and uniform, without any appearance of low molecular substances. Cobalt_57 activity distribution uniformity was scanned and detected to show that it has reached the specifications of commercial products (see details in Examples 3 and 4). Table-, the mixing and curing of bad oxygen resin / curing agent / organic solvent media materials under different formulations epoxy resin curing agent organic solvent mixing volume ratio (unit ml) Ί ---- stirring time I viscosity blending and processing Molding phenomenon AW 136H 991 Alcohol or acetone 750/250/200 15 minutes thick and slightly grayish thick liquid after blending, fast curing reaction rate, and inconvenient coating operation. AW 106 HV 953U Alcohol or acetone PEG-200 900/300/300 900/300/300 20 minutes 20 minutes Slightly thick, moderately mixed and stirred for 15 minutes, and then coated on the ABS-coated floor. Use a horizontal vibration bed to vibrate for 3 minutes. The water platform is left to stand for about three days to fully solidify. It is translucent and light yellow, and air bubbles are scattered on the upper layer, and the surface is uneven. PEG-200 and epoxy resin can be mixed and compatible with the function of dilution. After stirring for 15 minutes, it is coated on the abs coated board and left to stand on the water platform. It takes about five days for complete curing. There are fine air bubbles evenly distributed on the upper layer. The surface Smooth but with a small amount of PEG-200 precipitation, the uniformity of 57c〇 activity distribution is 1.88-2.1% rsd 〇 ΗΥ 956 PEG-200 1250/250/100 1 25 minutes_, the dilute 57Co solution is first dissolved in PEG_2〇〇, then It can stand for 30 minutes with epoxy resin and stand for 4 hours, and the air bubbles can be released 10 times. The paper size is applicable to China National Standard (CNS) A4 (210 X 297 mm) ------------- ------- ^ -------- (Please read the notes on the back before filling out this page) 516952 Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs A7 B7 V. Description of Invention (10) | After finishing the material & clearing, mix with the curing agent and stir for 18 minutes, then pour it into a horizontal solid state. {Teflon coated) Let it stand, completely cured after about a week, transparent yellowish without bubbles, the surface is flat Straight thickness is consistent without precipitation of any low-molecular substances, and the 57Co activity score is _ ___ 丨 uniformity of 0.59 ~ 0.7% rsd. Example 3: Plastic molding and gluing sealing The basic considerations for the production of flat sealed radioactive sources are that radioisotopes can be uniformly fixed in a flat-type curing medium, and have good airtightness, and there is no risk of radioactive material leakage. Regarding the chemical reaction mechanism that cobalt-57 can be uniformly fixed on Araldite M epoxy resin, it may be determined that the co2 + ion in 57C〇Cl2 aqueous solution firstly reacts with the hydroxyl group on the PEG-200 [HO (C2H4O) nH] solvent ( -0H) generates a substitution reaction, and the hydrogen atom of the other hydroxyl group of PEG-200 forms a hydrogen bond with the pair of electrons of the oxygen atom in the ether chain (-R-0-R) of Araldite M epoxy resin. Combined. The experiment proves that the molded source plate was wiped with dry filter paper to test the surface of the source plate. The filter paper activity was measured as the background value, showing that cobalt-57 can be stably fixed in the medium. The curing mold of the plastic radio source plate is divided into two parts. The upper mold is made of stainless steel with internal and external dimensions of 60cmLx41cmW x3CmT / 66cmLx47CmWx3Cmin. The lower mold is made of flat stainless steel and the external dimensions are 66cmLx47CmWx3cmT. After the stainless steel body is ground through the rough embryo, the whole surface is coated with Tefl 层 f, and then the surface is finely ground. The accuracy of its horizontal thickness can reach 0.003. The mobile precision platform used for the solidification of the molding medium material is made of 13 granulated granite with a plane accuracy of __〇〇〇8_, and the slate is placed on a two-speed pedal 11 paper scale. Applicable to China National Standard (CNS) A4 specifications (2_1〇x 297 public directors) — — — — — — — — — — — — IIIIIII > — — — — — — — — (Please read the notes on the back before filling in (This page) 516952 A7 Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs B7 V. Description of the invention (11) The platform is equipped with 4 fine-adjustment feet for level adjustment on the hydraulic lifting platform, which is stable and convenient to operate. Before molding, the horizontal level of the platform must be carefully adjusted with a digital spirit level, so that the level of the entire surface can reach 0.00-0.02. Then, the curing mold is placed on the platform, and the level of the template is checked. Then, according to the blending and operation steps of the plastic medium material formula of Example 2, pour into the mold for curing and molding, as shown in Table II. Please refer to the first picture. The cured source plate (10) has no shrinkage. After being lowered, it is placed in the ABS-covered base plate (20). The 5mm wide gap around it is epoxy resin adhesive ( AW 1〇6 / HV 953u, mixing volume ratio is 10: 8) Fill and fix the source plate (} 〇), and finally apply ABS glue to the four side grooves of the ABS coated plate (3 〇), and ABS The edge of the coated bottom plate (20) is glued and sealed to obtain a cobalt_57 plane sealed shot source. Covering board (30) (Glue on opposite sides of the four sides, width is 25cm and 2cm respectively, handles can be set to avoid direct contact and flat sealed radio source. Please refer to the second picture, the radio source transfer box box (4 〇 The bottom of the box is divided into 4 〃, small drag wheels (5 Q), and two special buckles (41) are attached to the front of the box, and a portable handle (not shown) is attached to the top of the box. One pull handle (4 2) each to facilitate the removal of flat sealed radio sources and storage of toilets. The linings on each side of the box are equipped with a thickness of 5 mm. The sponges and sponges are sufficient to meet the radiation protection safety requirements. Embodiment 4: Quality Control In order to ensure the stability and safety of the production quality of the Si-57 plane sealed shot source, the related quality control is extremely important. The present invention has successfully produced four cobalt ------------ Ψ ------- —Order --------- Line · (Please read the notes on the back before filling out this page) 12 516952 Printed by the Consumers ’Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs A7 B7 V. Description of the invention (12) Plane sealed radioactive sources (activities at the time of completion are 215.7, 241.2, 236.4 and 230.9 MBq, respectively), based on ANSIStandaΓdN542 · 1977, Appendix A Leak Test Methods Complete the quality control inspection. The related operations and test results are described as follows: (1) WiPe smear test: Wipe the surface of the solidified medium with wet filter paper and wet the filter paper. The surface of the ABS coated plate cover of the Cobalt-57 flat sealed shot was measured with an Eberline BC-4 counter (efficiency 35%). The results showed that the filter paper sample activities were all background values (2.OBq), far lower than the regulations. The value is 185Bq (5nCi), which is the worry of radioactive leakage pollution caused by the flat sealed radio source produced. (2) Activity distribution uniformity test · Make the radio source plate bracket and fixing clip, and seal the produced cobalt-57 plane The radiation source is fixed vertically in front of the Nal (Tl) detector collimator (the thickness of the sleeve is 5cm, the hole diameter is 12mm, and the hole depth is 20mm). It is 2mm away from the surface of the radiation source and 5cm from the long edge of the panel and 4cm from the wide edge. The computer is connected to the detection system and the application software program to automatically control the scanning useful area. The energy window of the chastity meter is set to 100-150keV, and the scanning movement is from bottom to top and left to right.彳 Inspection, the displacement distance of each detection point is 1 cm, the measurement time is 10 seconds, and the total area detection point is about 1734. Take the trial production of a cobalt-57 flat sealed shot source with an activity of 230.9MBq (6.24mCi) as an example. The test result of the activity distribution uniformity is shown in the fourth figure. 'The relative standard deviation of the activity distribution of cobalt-57 in the effective use range is 0.59 〇 / 〇, and it has been verified that it has reached the commercial product specification. The maximum relative standard deviation is a strict requirement of ± 1%. The above-mentioned relative standard deviation can also be referred to as the coefficient of variation (Coefficient of 13) This paper size applies to China National Standard (CNS) A4 (210 χ 297 public love) ---------------- ---- ^ --------- (Please read the notes on the back before filling out this page) 516952 A7 Five Inventions U3) vanatum) 'Designed as a computer software fruit with the following formula' and color To distinguish between different relative average measured value deviations and calculate the test activity distribution, please refer to the fourth figure. R.s.
N (Xi-X)2/N-1 -χ x 100% 經 濟 部 智 慧 財 產 局 員 工 消 費 合 作 社 印 製 式中偵測點總數（約為1734)，沿二夸 值，χ=總偵測點平均計測值。 ⑶介質抗輕射線評估：從報導資料顯示， 收劑量為 3.07 Rad._Ci.h (David A Weber =7 單位吸 Radionuclide Date and Decay Schemes, 1989) 〇 ^ ^〇： -57平面密封射源製作所使用之介質材料總重^對本發明結 估’若以钻-57裝填活度為37〇MBq(1〇mCi)，均、=00g砰 質材料塑製成型之射源平板後，固著於ABs祜二刀佈在介 、 饿覆板套中， 估計射源使用一年其總吸收劑量< Ι 68χ1 3 1U Qy(1.68xl〇5 Rad)。將前述介質材料塑模固著於ABS塑膠板之試樣，經 始-60照射總劑量達1〇5 Gy(107 Rad)，結果驗証其抗輕射性 質良好。 (4)撞擊試驗：將塑製成型之射源平板以環氧樹脂黏著劑 (AW106/HV953U)固著於ABS被覆底板上，在密封前將其自 1 · 5 m局處作掉洛測試’結果顯不射源平板固定性良好，益 任何碎裂或變形現象。 此外，為瞭解鈷-57平面密封射源製作及裝箱後之環土竟 谓測點計測 (請先閱讀背面之注意事項再填寫本頁) |裝--------訂---- 籲· 14 本紙張尺度適用中國國家票準（CNS)A4規格（210 x 297公爱） 經濟部智慧財產局員工消費合作社印製 516952 A7 B7 五、發明說明（14) 輻射背景，利用手提式輻射偵檢器量測已完成製作四個鈷-57 平面密封射源（215.7-241.2MBq)之輻射劑量率，結果綜合如 附表三，顯示持握射源把手處可有效降低工作人員輻射曝 露，而傳送箱不論在寬側面、窄側面及頂部表面之輻射劑量 率皆<2(^Sv/h，足以達到輻射防護安全之要求。 表三、鈷-57平面密封射源實體之表面輻射劑量率 \製作活度 位置 射源平板（gSv/h) 傳送箱(MSv/h) 215.7 241.2 236.4 230.9 215.7 241.2 236.4 230.9 平板表面 165 169 166 159 側邊把手 20 26.5 26 25.5 頂部表面 7.8 8.9 8.6 9.2 寬側面 15.5 18.8 17.4 17.1 窄側面 9.3 9.7 9.2 8.6 由以上說明可知本發明乃採用一種混合物質具有可塑性 高、相容性佳及抗輻射性質良好之介質材料，在適當配方下 能與鈷-57水溶液均勻混合，並利用特別設計及操作方便之 水平固化模具，製作鈷-57平面密封射源，可提供加馬攝影 機探頭校正使用，提高儀器在臨床上擷取數據之準確性及增 進分子影像診斷判斷效果，對我國核子醫學診斷將有明顯的 貢獻。 圖不說明： 第一圖係本發明鈷_57平面密封射源示意圖與實體。 第二圖係本發明使用傳送箱示意圖與實體。 第三圖係本發明鈷-57平面密封射源製作流程。 第四圖係本發明鈷·57平面密封射源活度分佈均勻性鑑 15 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） ------------裝--------訂--------- (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 516952 A7 B7 五、發明說明（15) 定。 附表一：鈷-57同位素之製備。 附表二：環氧樹脂/固化劑/有機溶劑介質材料在不同 配方下摻合及固化情形。 附表三：始-57平面密封射源實體之表面輻射劑量率 圖號說明： 射源平板..........10 ABS被覆底板.....：..20 ABS被覆板.........3 0 箱子............4 0 扣鎖............4 1 把手· · · .........4 2 拖行輪...........5 0 高純度鈷-57同位素之製備·· 6 0 介質材料選擇與組成配方摻合·70 塑製成型與膠合密封.....8 0 品質管制..........9 0 制式靶體..........10 0 照射............110 溶解............120 層析分離..........13 0 淘洗............13 1 清洗............132 回收............133 16 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） ------------------- 訂--------- (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 516952 A7 B7 五、發明說明（1β) 參考文獻 1. E. Browine and R. B. Firestone, : Tables of Radioactive Isotopes(V. S. Shirley, ed.)5 John Wiley and Sons, Inc., New York(1986). 2. B. E. Oppenheim and C. R. Appledorn，、、Uniformity Correction for SPECT Using a Mapped Cobalt-57 Sheet Sourcer/ ? J. Nucl. Med., 26, 409(1985). 3. W. Chang, S. Li, J. J. Williams et al.5 vvNew Methods of Examing Gamma Camera Collimator"，J. Nucl. Med.，29. 676(1988). 4. Du Pont Merck Pharmaceutical Co. -The Du Pont Cobalt-57 Rectangular Flood Source, 331 Treble Cove Road, N. Billerica, MA，USA 01862. 5. Nycomed Amersham plc-Qcheck Cobalt-57 Flood Field Sources，Amersham Place, Little Chalfont，Buckinghamshire， England HP7 9NA. 6.Istope Products Laboratories - IPL Cobalt-57 Flood Sources, 1800 North Keystone Street, Burbank, CA? USA 91504· 7. Analytics, Inc. - Aluminum - Encased Flood Sources for Gamma Camera Quality Control, 1380 Seaboard Industrial Blvd.? Atlanta, GA? USA 30318. 8. R. C. Me Farland and P. A. Me Farland, vvMethod of Producting Liquid Equivalent Solid Gamma Ray Calibration Standards"，US Patent 4430258, Feb. 7, 1984. 17 本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） --------------------訂--------- (請先閱讀背面之注意事項再填寫本頁) 516952 A7 _B7_ 五、發明說明（17) 9.W. L. Cheng, Y. Jao5 J. D. Sheu et al.? vv Study on Production of High Purity Cobalt-57 with a Compact Cyclotron，，，Nucl. Sci. J.，M，1(2000). (請先閱讀背面之注意事項再填寫本頁) 訂---- 4. 經濟部智慧財產局員工消費合作社印製 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐）N (Xi-X) 2 / N-1-χ x 100% The total number of detection points (approximately 1734) in the printed format of the employee consumer cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs, along two exaggerated values, χ = average of the total detection points Measured value. (3) Evaluation of medium against light rays: According to the reported data, the received dose is 3.07 Rad._Ci.h (David A Weber = 7 units of Radionuclide Date and Decay Schemes, 1989) 〇 ^ ^ 〇: -57 Flat sealed source production The total weight of the dielectric material ^ According to the present invention, if the filling activity of the drill-57 is 37.0 MBq (10 mCi), the homogeneous, = 00 g ping material is molded into a source plate and then fixed to ABs The two-bladed cloth was placed in a cover plate and a cover plate. It is estimated that the total absorbed dose of the radiation source for one year is <68 x 1 3 1U Qy (1.68 x 105 Rad). The sample of the aforementioned dielectric material was fixed on the ABS plastic plate, and the total dose of -60 irradiation reached 105 Gy (107 Rad). The results verified that its light resistance was good. (4) Impact test: A plastic-made radiation source plate is fixed on an ABS-covered base plate with an epoxy adhesive (AW106 / HV953U), and it is subjected to a drop test from a 1.5 m station before sealing. 'The results show that the source plate is well fixed, and any chipping or deformation phenomenon is benefited. In addition, in order to understand that the circum-soil after the production and packing of the Cobalt-57 plane sealed radio source is actually measured by measuring points (please read the precautions on the back before filling this page) | Installation -------- Order-- -Call · 14 This paper size applies to China National Standard for Tickets (CNS) A4 (210 x 297 public love) Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 516952 A7 B7 V. Description of the invention (14) Radiation background, using portable The radiation detector has measured the radiation dose rate of four Cobalt-57 flat sealed radioactive sources (215.7-241.2MBq). The results are shown in Table 3, which shows that holding the radioactive source handle can effectively reduce staff radiation. Exposure, and the radiation dose rate of the transfer box on the wide side, narrow side and top surface is <2 (^ Sv / h), which is sufficient to meet the requirements of radiation protection safety. Table III. Surface of Cobalt-57 Flat Sealed Source Radiation Dose Rate \ Make Active Position Source Plate (gSv / h) Transfer Box (MSv / h) 215.7 241.2 236.4 230.9 215.7 241.2 236.4 230.9 Plate Surface 165 169 166 159 Side Handle 20 26.5 26 25.5 Top Surface 7.8 8.9 8.6 9.2 Wide side 15.5 18.8 17.4 17.1 Narrow side 9.3 9.7 9.2 8.6 From the above description, it can be seen that the present invention uses a mixed material with high plasticity, good compatibility and good radiation resistance. It can be uniformly mixed with a cobalt-57 aqueous solution under an appropriate formula. And using a specially designed and easy-to-operate horizontal curing mold to produce a Cobalt-57 flat sealed radiation source, which can provide calibration for Gama camera probes, improve the accuracy of the data captured by the instrument in the clinic, and improve the effect of molecular imaging diagnosis. China ’s nuclear medicine diagnosis will make a significant contribution. The picture does not illustrate: The first picture is the schematic diagram and entity of the cobalt_57 plane sealed shot source of the present invention. The second picture is the schematic diagram and entity of the present invention using a transfer box. The third picture is the present invention The production process of Cobalt-57 flat sealed radioactive source. The fourth picture is the uniformity of activity distribution of Cobalt · 57 flat sealed radioactive source according to the present invention. 15 This paper size is applicable to China National Standard (CNS) A4 (210 X 297 mm)- ----------- Equipment -------- Order --------- (Please read the precautions on the back before filling out this page) Staff Consumption of Intellectual Property Bureau, Ministry of Economic Affairs Cooperation Printed 516952 A7 B7 V. Description of the invention (15). Appendix I: Preparation of cobalt-57 isotope. Appendix II: Epoxy resin / curing agent / organic solvent media material blended and cured under different formulations. Attached Table 3: Surface Radiation Dose Rate Chart of Shi-57 Plane Sealed Radiation Source Entity Description: Radiation source plate .......... 10 ABS coated bottom plate .....: .. 20 ABS coated plate ......... 3 0 Boxes ......... 4 0 Buckle ......... 4 1 Handle ..... 4 2 Towwheel ........... 5 0 Preparation of high-purity cobalt-57 isotope · 6 0 Selection of media materials and composition blending · 70 plastic molding and Glue seal ... 8 0 Quality control ......... 9 0 Standard target body ......... 10 0 Irradiation ... .110 dissolve ......... 120 chromatographic separation ......... 13 0 elutriation ......... 13 1 wash ... .......... 132 Recycling ............ 133 16 This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) ----- -------------- Order --------- (Please read the notes on the back before filling out this page) Printed by the Employee Consumption Cooperative of Intellectual Property Bureau of the Ministry of Economic Affairs 516952 A7 B7 Fives Description of the Invention (1β) References 1. E. Browine and RB Firestone,: Tables of Radioactive Isotopes (VS Shirley, ed.) 5 John Wiley and Sons, Inc., New York (1986). 2. BE Oppenheim and CR Appledorn ,,, Uniformity Correction for SPECT Using a Mapped Cobalt-57 Sheet Sourcer /? J. Nucl. Med., 26, 409 (1985). 3. W. Chang, S. Li, JJ Williams et al. 5 vvNew Methods of Examing Gamma Camera Collimator ", J. Nucl. Med., 29. 676 (1988). 4. Du Pont Merck Pharmaceutical Co. -The Du Pont Cobalt-57 Rectangular Flood Source, 331 Treble Cove Road, N. Billerica, MA, USA 01862. 5. Nycomed Amersham plc-Qcheck Cobalt-57 Flood Field Sources, Amersham Place, Little Chalfont, Buckinghamshire, England HP7 9NA. 6. Istope Products Laboratories-IPL Cobalt-57 Flood Sources, 1800 North Keystone Street, Burbank, CA ? USA 91504 · 7. Analytics, Inc.-Aluminum-Encased Flood Sources for Gamma Camera Quality Control, 1380 Seaboard Industrial Blvd.? Atlanta, GA? USA 30318. 8. RC Me Farland and PA Me Farland, vvMethod of Producting Liquid Equivalent Solid Gamma Ray Calibration Standards ", US Patent 4430258, Feb. 7, 1984. 17 This paper size applies to China National Standard (CNS) A4 (210 x 297 mm) ---- ---------------- Order --------- (Please read the notes on the back before filling out this page) 516952 A7 _B7_ V. Description of the invention (17) 9 .WL Cheng, Y. Jao5 JD Sheu et al.? Vv Study on Production of High Purity Cobalt-57 with a Compact Cyclotron ,,, Nucl. Sci. J., M, 1 (2000). (Please read the first Note for this page, please fill in this page) Order ---- 4. The paper size printed by the Employees' Cooperatives of the Intellectual Property Bureau of the Ministry of Economy applies the Chinese National Standard (CNS) A4 specification (210 X 297 mm)