TW495354B - Radio-frequency based co-axial cable and catheter system for ablation of body tissues - Google Patents

Abstract

An improved radio-frequency catheter system for ablating biological tissues of a body vessel in a patient including a catheter, a deployable antenna guide disposed at the distal portion of the catheter and a radio-frequency (""RF"") antenna mounted on the antenna guide. The RF antenna includes a axial passageway to accommodate the antenna guide, and is adapted to receive and transmit RF energy for tissue ablation. Upon deployment, the antenna guide acquires a configuration configuration which establishes line contact with the body vessel conformable to its internal contour to prescribe the precise and affixed tissue ablation pathway despite body vessel movements. The RF antenna is carried by the antenna guide to be deployed along the established tissue ablation pathway. Alignment of the configuration with the desired tissue ablation pathway is facilitated with the use of radio-opaque markers and intracardiac electrodes mounted along the antenna guide. The catheter, as well as the antenna can be provided with steering or deflection mechanism for navigation through the body vessel passageways.

Description

V. Description of the invention (1) Background and field of the invention · Internal biological tissue cauterization (for arrhythmia) The present invention relates to a radiofrequency catheter medical device applied to a patient's blood vessel ablating, particularly > , Laigu: Biomedical devices have made great progress in the application of heart disease or other serious conditions; traditionally, these conditions-usually by drugs or Feng: First, the medical community hopes to find better invasive surgical methods and effects Less residual medication. Second, by

The progress' has made a major breakthrough in the development of convenient and effective medical devices. Atrial Fibrillation (AF), a rapid irregular rhythm of the atrium or heart chamber caused by irregular stimuli, often causes a heart attack and places a heavy burden on the body. Nowadays, the most effective surgical method for treating atrial fibrillation is a kind of happy operation called "Maz e procedure". This method is to open all mouths in a predetermined place on the atrium and then suture. When healing, the incision will be scarred, which is equivalent to setting a boundary for the conduction of ECG stimulation. Therefore, atrial fibrillation will not occur and the heart will return to normal rhythmic beating. However, '' Maze procedure β is not widely adopted because of its recurrence rate and the high risk associated with having to open the chest and ribs with open surgery. A similar, "Maze procedure" technology is radiofrequency catheter cauterization technology 'using catheter electrodes to destroy or cauterize atrial tissue to replace the hand IE I i 1 I 1 1 Ϊ I 1 Page 5 V. Description of the invention (2), The incision is based on the existing catheter-based therapy: forming a linear boundary and a line to prevent the scorching of the improper transmission of electrical stimulation. Therefore, it is necessary to place the electrode on a predetermined point. You must know the electricity: more than 12 hours Furthermore, during the treatment, == ::: these methods must be protected by a thick lead wall, and Lauin ί: roads under radiation may cause safety problems for doctors or patients' so such a catheter system and * Commonly used. * Wangmen shout No. 249 is used to reduce the risk of reducing-lowering / moving the path, for example *, in US Patent No. 5, ⑷, the end ^ ϋ ϋΐ catheter-based microwave antenna is used to expose it = On the wall. "Although this design reduces the possibility of slippage in the early cautery step, it is firmly and precisely fixed in the second two: after each cauterization step, the antenna must be on the aforementioned, cautery road, : 2 at the bottom-point position, and this The position must be within the space of the path or close to its tolerance; if the benefit line is called 'the material passes the boundary line of the pulse leakage transmission wheel': it causes a problem due to the two-day fiber: clever; can continuously burn the atrium in a linear or curved shape Inside.

V. Explanation of the invention (3) Effectively forming a barrier to the stimulation signal, and solving the problem of atrial fibrillation. In summary, the design of the catheter system provided by the present invention can be used not only for the cardiac system, but also for the burning of vascular tissues in the body. This catheter binds the human body: a qualitative and fixed position mechanism. It uses the antenna to guide and control the sensors; I! Guides and monitors the sensors with different parameters during the burning period, and makes the guide slide easy to operate and control. Description of drawing number: ° 1 2 Proximal part 18 conduit opening M connector 40 Top part 54 RF antenna 7 Printer 10 tube body 1 4 End part 20 Manual control device 3 Conduit-6 RF energy controller antenna guide computer details Description: Ben Mingyi ^ Intravascular tissue and an improved radiofrequency catheter system to provide the body with the function of two internal wall ablation. This system combines one; a catheter into the blood vessel of the human body, a catheter antenna, and a radio frequency antenna (radi0—freQuency to the treatment point), which is positioned to the desired position by means of el ectromaSnet ic energy. The required 2-wire guide (an tenna guide) can illuminate the antenna accurately. It can also be used in the same way. (Ablati〇n Pathway) 'At present, this process is described by the co-axial cable. ) To transmit electromagnetic energy, and the antenna is used for the antenna approach, 7 丨 waiting for an entry path.

V. Description of the invention (4) As shown in FIG. 1, the present invention includes a catheter 3, which is used to enter a blood vessel in a patient's body. The catheter has an elongated and flexible tubular body 10, It has a proximal portion (prOximai porti-n) 12 and a distal portion (distal por0-n) 14, and at the proximal portion 12 of the catheter 3 there is a place for manipulation, A handle chassis 20 for controlling positioning will be described in more detail later. The proximal end of the combined catheter 3 is a coupling 22, which is connected to various electrodes (not shown) to support the cauterization procedure. The size of ^ can be different according to the specific medical procedure. The tube body 10 of the catheter 3 is generally a biocompatible (bi0-ε ompaUble) catheter, which is a polymer suitable for the intravascular environment. It also has elasticity, degree of stiffness and twisting weight K degree and = = Ϊ and easier to pass through the patient's body blood vessels, and the torque is transferred ~ the length of the guide from the proximal part to the terminal part. Lai Ming: The operation of the two catheters is through a pull wire (PuU wire, which is extended by the control manual control device 20 all the way to the end of the catheter 3 ^ 14, at the end of the catheter 3, the pull wire (Enng) or other suitable means to fix the catheter wall. The guidance system of the present invention provides an effective device for directing a shot: a line to complete the tissue cautery along a predetermined cauterization path. The first household:: bow 丨 Daoguang line guide 6, which is connected to The terminal part of the catheter 3 is "front display door, and the antenna guide 6 can also shrink the θ channel;

Qi play π / catheter lumen. The M or retract of the antenna 54 and the antenna guide 6 is unfolded from the tip guide 6 of the catheter, either manually or by means of: the proximal tail ′ and 4 π are controlled by electronic and mechanical mechanisms. 495354 V. Description of the invention (5) = The scheduling of the line guide 6 can contact the inner condyle of the vascular tissue by controlling the glide to the end of the catheter 3 and adjusting the length of the extension of the opening 18 of the catheter. With such contact, the degree of extension of the antenna guide can be adjusted to the desired configuration size. Depending on the condition of the contour of the blood vessel to be treated, the size of the configuration can be controlled by the antenna to guide the slide to match the contour of the blood vessel. Since the antenna 2 has spring-like elasticity, the antenna will still be partially linear despite the movement of the blood vessel. It is in contact with vascular tissue, and the apex 44 0 on the antenna guide can further fix the antenna guide on the small concave bit of the A tube without rupturing the blood vessel. In order to know the position of the antenna guide in the blood vessels of the body, we set one or more radiation opaque markers (1 ^ (11〇 一 opaque markers) on it because the material of the radiation is opaque, which makes the antenna guide 6 and its top portion 40 are opaque to X-ray or fluoroscopic inspection, so it can help to insert the catheter or determine when burning is performed. 'Among them, the structure and use of radiopaque markers in the catheter The technology is a known technology, so it will not be repeated here. The present invention includes a radio frequency antenna (RF antenna) 54 which is arranged at the end portion of the adjacent catheter 3 and used for cauterizing tissue. The present invention has various different Radio frequency antenna to cooperate with the antenna guide, so as to be used for the organization of the configuration of the air gap. In a specific embodiment of the present invention, the radio frequency antenna includes: an electrically conductive material or a metal wire, and is spirally formed. Form a spiral coil, and the appropriate diameter, strength (pi tch) and length of the wound coil, and also choose the conductive material or metal wire Is an important choice 'to have different options depending on the need for surgery, and are not detailed mediated

Page 9 495354 The conductive part in front or inside and the surname ’This energy is controlled by the RF energy controller; the layer is not conductive and the closest thing is completely conductively connected on the insulating layer. It is controlled by the environment and electric energy, and the radio frequency energy and radio frequency are in contact with each other. Because of this invention, V. Invention Description (6) The radio frequency antenna will be first contacted and then combined with radio frequency energy. The inner electrical conductor will be extended to the composition by a surface around it. The inner and outer layers of the conductive RF antenna can be connected to the coiled conductor. After that, the RF power provided by the outer body forms a Blncapsulant electric body. And provide a body bio-ring radio frequency antenna that can generate radio frequency energy from radio frequency energy, and suitable radio frequency spectrum is that micro antennas can evenly absorb electromagnetic energy and the transmission system is evenly distributed around it to generate an energy field. The antennas are evenly distributed on the antenna. A hand-held device wrapped in a tissue or hemoelectric polymer is caused by this insulation. The outer surface of the layer is made of a material suitable for radio frequency energy and encapsulates the magnetic and thermal response of the insulator 5 at a range of 300mHz to be emitted from the antenna on the long axis of the line. However, the burning required by the tissue can be reduced. The previous cover was approached or contacted, and the cover was converged and formed an outer layer leading edge with the outer layer controller 5. Transmitting electromagnetic, radio frequency. After the electromagnetic energy is absorbed, the hot spot catheter of the technology can pass through an opening and pass through the body's blood vessels to reach the vicinity of the tissue to be burned. Before entering, the antenna guide 6 and the radio frequency antenna 5 4 will be radio-opaque. The inside of the marker's catheter allows it to pass smoothly, and then the end portion 1 of the catheter 3 enters through the body opening for operation control

Page 10 495354 V. Description of the invention (7) When it reaches the position where it is to be cauterized, it is completed by directly controlling the rotation of the manual control device and using the offset control. The placement of the RF antenna guide 6 or the antenna 54 "can be confirmed by a radio-opaque marker, and its position can be detected by an appropriate X-ray or fluorescent device. When the end of the catheter 3 is placed near the tissue to be cauterized When it is around, the antenna guide can be removed from the lumen of the catheter through the control slide and deployed into the configuration described above. Depending on the shape and size of the tissue in the tube, one or two antenna guides can be obtained by controlling the sliding operation. The desired size and shape, as well as the size and shape of the tissue, can be further obtained from the ECG electrodes in the heart, so as to provide the doctor to guide the RF antenna or arrange the RF antenna in the desired path. ^ ^ For example, the antenna, then At least part of the atrium should be removed from the catheter when the inner side of the angel guides one of its inner wall lines to guide the treatment. After that, the group needs to burn the long antenna that is in line with the internal wall beat of the body, so the antenna can be fixed. The antenna moves through the radiation, and the contact that stays in the Ί structure is caused by burning. Find the guide and do not adjust the guide to the frequency energy to guide and use the length of the cautery and the atrial wall antenna to guide the arcade, the inner wall of the atrium in the body ik to adjust the treatment, and then hope to complete the cauterization. The cheek energy to the antenna The bit line guides the structural symbol of the space shape; when the atrium will follow the adjustment position, the inner cavity of the manual control device can be adjusted by the antenna through the weaving and burning, so it is at least flexible and can stay in contact with the name. In the tube, I want U treatment points to be parallel to the correct position of the seven RF antennas.] Different treatments can reach the desired housing configuration, ^

495354

To avoid the step of capturing, cadaver ... in the path of tissue burning. There are changes. The antenna is fixed to the phase between the blood vessel and the body. The grid that leaks electricity can be emphasized according to the specific surgical requirements. #J 价 表 'Another embodiment of the invention described above further includes any In this embodiment, the antenna guide 6 includes a 1-lead design so that the system has a slender elasticity that terminates at the distal end of the terminal 40. The application of i 'extends into the catheter 3 to be burned; the end guide 6 will It extends beyond the opening of the catheter 18, and the main #, and weave around the gap on the surface of the body's blood vessels, and the antenna leads: adjust the shape of the tube tissue contour and adjust the shape of the natural path A 〇 The eight-lead guide 6-shaped fish body j-shaped contact, $ -like, come, the displacement of the center of the antenna guide will be reduced, and then the RF antenna 54 is taken out of the antenna cavity, and the path of its burning position is between the antenna blood vessels The linear contacts are parallel to each other. In other embodiments, the RF antenna is designed in a way that the RF antenna of the present invention may actually have different shapes, such as spiral, monopole, and elastic wires_ I = i, one or more ECG The metal wire is connected to one or more electrodes of the terminal part of the county after the shooting of the present invention, so as to obtain the ideal tissue adjacent position and electrical conduction measurement situation before the tissue is cauterized. Gold] The antenna system of the present invention includes a Or more or more antennas are flexed or controlled to ψ Mb, so as to fix the antenna end part, so that the antenna forms a more suitable metal wire connected to this X 'antenna end, which can increase the degree of bending of the antenna at this point. In principle 'The entire system is controllable and data can be retrieved

V. Description of the invention (9) and any device that can be programmed and recorded ... The computer can be familiar with the following points: the present invention effectively reduces the path of the tissue to be burned as defined by the line guide. Material shot; = landing A continuous burning path, which greatly reduces the risk of leakage of electronic pulses. Because of the &, the present invention does not need to: place: produce ^ " r :: r, on Maze; say: upper 上 :: specific explanation, plus practical applications where the spirit and architecture of the invention are inconsistent Without violating, the examples are only for explaining the technical ideas and characteristics of the present invention. The same changes or modifications made to the spirit disclosed in the present invention should still be included in the scope of the patent of the present invention. . Decoration,

495354 Brief Description of Drawings Figure 1 is a schematic diagram of the radiofrequency catheter burning system of the present invention, which includes a radio frequency power module, a computer control and a data recording device. ❿ Page 14

Claims (1)

495354 6. The scope of patent application ____ 1 · An application for cauterizing biological tissues in the blood vessels of the body, including: Catheter only a)-Catheters, which are used to extend into the blood vessels of a patient's body, the catheter spoon contains a proximal end Part, a terminal part with a terminal opening extending from the proximal part to the lumen of the terminal part; b) an elongated antenna guide which is arranged in the lumen of the catheter and can protrude from the distal opening of the catheter And unfolded so as to make proper contact with the internal contours of the blood vessels of the body; and the stomach c) a radio frequency antenna, which is arranged at the end of the catheter and has a path for the antenna to pass through, the radio frequency antenna is used for receiving And emit radio frequency energy to scorch biological tissue along the biological cautery path. Work 2 The catheter system described in item 1 of the scope of the patent application, which is more conductive, combines the RF antenna and extends to the inner cavity of the nearest part of the catheter. 4 The duct system as described in item 2 of the scope of patent application is used to transmit radio frequency energy. " The catheter system according to item ^, wherein the antenna 2 has the catheter system described in item 1 of the extended patent range which extends in the catheter lumen, and on that day 6 as described & 2 3 ί (an ECG electrode in the heart. The catheter complex guidance as described in item 1 of Shenqiao's patent scope is composed of a plurality of elongated members 蛀 / ,,, '/, ΌΛ,'. The combination is then combined into one Single antenna Page 15 495354 6. Scope of patent application 1 --- 7 • The catheter system according to item 1 of the scope of patent application, wherein the antenna guide further includes at least one tip end portion made of a material that is opaque to radiation. 8. A radiofrequency catheter system for cauterizing biological tissues in the blood vessels of the body, including: a) Catheter 'is used to extend into the blood vessels of a patient's body. The catheter includes a proximal portion and a distal opening. A distal portion and a lumen extending from the proximal portion to the distal portion; b) an elongated antenna guide disposed in the lumen of the catheter and having a first portion connected to the distal portion of the catheter A distal end portion, a second distal end portion extending from the lumen of the catheter to the proximal end, the antenna guide can be extended and unfolded from the opening of the distal end of the catheter, and can make proper contact with the internal contour of the blood vessel of the body; and c) A radio frequency antenna is arranged at the end of the catheter. The antenna has an axial path for receiving the antenna to guide through. The radio frequency antenna is used for receiving and transmitting radio frequency energy to cauterize the biological tissue along the biological cautery path. 9 An RF catheter system for cauterizing biological tissues in the blood vessels of the body, including: a) a catheter, which is used to extend into a patient's blood vessel, the catheter includes a proximal portion, a distal portion with a distal opening, and a lumen extending from the proximal portion to the distal portion; b) — a slender and flexible antenna guide, which is arranged in the lumen of the catheter and can be extended and unfolded from the opening at the end of the catheter to communicate with the body's blood 495354 6. The scope of the patent application The tube forms a linear contact and can make proper contact with the internal contours of the blood vessels of the body; and C) A radio frequency antenna is arranged at the end of the catheter. The antenna has a shaft path to accommodate the antenna Guided through, the radio frequency antenna is used to receive and transmit radio frequency energy to cauterize the biological tissue along the cauterization path. 1 0 · The catheter system according to item 1 of the scope of patent application, further comprising at least one elongated and bent metal wire fixed at the end of the antenna and extending to the proximal end of the antenna, and the bent metal wire system Used to complete the deflection of the antenna end. Page 17