TW492868B - Peptide compounds useful for treating MHC class II dependent T-cell medicated autoimmune or inflammatory diseases and pharmaceutical compositions containing same, and process for preparing same - Google Patents

Peptide compounds useful for treating MHC class II dependent T-cell medicated autoimmune or inflammatory diseases and pharmaceutical compositions containing same, and process for preparing same Download PDF

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Publication number
TW492868B
TW492868B TW086115279A TW86115279A TW492868B TW 492868 B TW492868 B TW 492868B TW 086115279 A TW086115279 A TW 086115279A TW 86115279 A TW86115279 A TW 86115279A TW 492868 B TW492868 B TW 492868B
Authority
TW
Taiwan
Prior art keywords
ala
group
peptide
amino acid
arg
Prior art date
Application number
TW086115279A
Other languages
English (en)
Chinese (zh)
Inventor
Richard Willam Arthur Luke
Ronald Cotton
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Application granted granted Critical
Publication of TW492868B publication Critical patent/TW492868B/zh

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/81—Drug, bio-affecting and body treating compositions involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, immunotolerance, or anergy
TW086115279A 1996-10-19 1997-10-17 Peptide compounds useful for treating MHC class II dependent T-cell medicated autoimmune or inflammatory diseases and pharmaceutical compositions containing same, and process for preparing same TW492868B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9621836.7A GB9621836D0 (en) 1996-10-19 1996-10-19 Peptide compounds

Publications (1)

Publication Number Publication Date
TW492868B true TW492868B (en) 2002-07-01

Family

ID=10801703

Family Applications (1)

Application Number Title Priority Date Filing Date
TW086115279A TW492868B (en) 1996-10-19 1997-10-17 Peptide compounds useful for treating MHC class II dependent T-cell medicated autoimmune or inflammatory diseases and pharmaceutical compositions containing same, and process for preparing same

Country Status (10)

Country Link
US (1) US6207644B1 (US06207644-20010327-C00003.png)
EP (1) EP0932618B1 (US06207644-20010327-C00003.png)
JP (1) JP2001508036A (US06207644-20010327-C00003.png)
AT (1) ATE256145T1 (US06207644-20010327-C00003.png)
AU (1) AU4633097A (US06207644-20010327-C00003.png)
DE (1) DE69726743T2 (US06207644-20010327-C00003.png)
GB (1) GB9621836D0 (US06207644-20010327-C00003.png)
TW (1) TW492868B (US06207644-20010327-C00003.png)
WO (1) WO1998017680A1 (US06207644-20010327-C00003.png)
ZA (1) ZA979338B (US06207644-20010327-C00003.png)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100451522B1 (ko) * 1996-06-07 2004-12-08 아스트라제네카 유케이 리미티드 펩티드유도체
CA2376903A1 (en) 1999-06-25 2001-01-04 Emory University Devices and methods for vagus nerve stimulation
TW200502221A (en) 2002-10-03 2005-01-16 Astrazeneca Ab Novel lactams and uses thereof
AU2004212954B2 (en) * 2003-02-14 2008-07-17 Provid Pharmaceuticals, Inc. Inhibitors of antigen presentation by MHC class II molecules and methods of use thereof
JP2006520396A (ja) 2003-03-14 2006-09-07 アストラゼネカ・アクチエボラーグ 新規なラクタム及びその使用
CA2547651C (en) * 2003-12-01 2015-06-23 Cambridge University Technical Services Limited Anti-inflammatory agents
AU2008331789A1 (en) * 2007-12-03 2009-06-11 Provid Pharmaceuticals, Inc. Inhibitors of antigen presentation by MHC Class II molecules and methods of use thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4474778A (en) 1983-11-09 1984-10-02 E. R. Squibb & Sons, Inc. Lactam containing compounds, their pharmaceutical compositions and method of use
DE3711335A1 (de) 1987-04-03 1988-10-20 Merck Patent Gmbh Aminosaeurederivate
US5223485A (en) 1989-01-31 1993-06-29 Abbott Laboratories Anaphylatoxin-receptor ligands
WO1992002543A1 (en) * 1990-08-01 1992-02-20 Cytel Corporation Novel immunosuppressant peptides
DE4034829A1 (de) 1990-11-02 1992-05-07 Merck Patent Gmbh Cyclopeptide
WO1993005011A1 (en) 1991-08-29 1993-03-18 Sandoz Ltd. Novel immunosuppressants
DE69413167T2 (de) 1993-06-04 1999-05-06 Vertex Pharma Peptid-Phosphinyloxymethyl-Ketonen als Inhibitoren von Interleukin-1 beta-konvertierenden Enzymen
PT735893E (pt) 1993-09-14 2009-03-06 Pharmexa Inc Péptidos que se ligam aos alelos pan dr para aumentar a resposta imunitária
AU2238395A (en) 1994-04-01 1995-10-23 Immulogic Pharmaceutical Corporation Haptenated peptides and uses thereof
EP0815123B1 (en) 1995-03-24 2001-10-04 Molecumetics, Ltd. Beta-sheet mimetics and use thereof as protease inhibitors
US5840835A (en) * 1995-10-30 1998-11-24 Merck & Co., Inc. Inhibitors of peptide binding to MHC class II proteins
US5719296A (en) 1995-10-30 1998-02-17 Merck & Co., Inc. Pseudopeptide lactam inhibitors of peptide binding to MHC class II proteins
US5817757A (en) * 1995-10-30 1998-10-06 Merck & Co., Inc. Inhibitors of peptide binding to MHO class II proteins
AU7604196A (en) 1995-10-30 1997-05-22 Merck & Co., Inc. Novel inhibitors of peptide binding to mhc class ii proteins
GB9702377D0 (en) * 1996-02-23 1997-03-26 Zeneca Ltd Peptide derivatives

Also Published As

Publication number Publication date
DE69726743D1 (de) 2004-01-22
JP2001508036A (ja) 2001-06-19
WO1998017680A1 (en) 1998-04-30
GB9621836D0 (en) 1996-12-11
DE69726743T2 (de) 2004-10-14
EP0932618A1 (en) 1999-08-04
EP0932618B1 (en) 2003-12-10
ATE256145T1 (de) 2003-12-15
US6207644B1 (en) 2001-03-27
ZA979338B (en) 1998-04-20
AU4633097A (en) 1998-05-15

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Legal Events

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GD4A Issue of patent certificate for granted invention patent
MM4A Annulment or lapse of patent due to non-payment of fees