TW427968B - Process for manufacturing simvastatin from lovastatin or mevinolinic acid - Google Patents
Process for manufacturing simvastatin from lovastatin or mevinolinic acidInfo
- Publication number
- TW427968B TW427968B TW086111652A TW86111652A TW427968B TW 427968 B TW427968 B TW 427968B TW 086111652 A TW086111652 A TW 086111652A TW 86111652 A TW86111652 A TW 86111652A TW 427968 B TW427968 B TW 427968B
- Authority
- TW
- Taiwan
- Prior art keywords
- lovastatin
- simvastatin
- starting material
- cyclopropyl
- pyranone ring
- Prior art date
Links
- QLJODMDSTUBWDW-UHFFFAOYSA-N lovastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(C)C=C21 QLJODMDSTUBWDW-UHFFFAOYSA-N 0.000 title abstract 6
- RYMZZMVNJRMUDD-UHFFFAOYSA-N SJ000286063 Natural products C12C(OC(=O)C(C)(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 RYMZZMVNJRMUDD-UHFFFAOYSA-N 0.000 title abstract 4
- 229960004844 lovastatin Drugs 0.000 title abstract 4
- PCZOHLXUXFIOCF-BXMDZJJMSA-N lovastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 title abstract 4
- 229960002855 simvastatin Drugs 0.000 title abstract 4
- RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- QLJODMDSTUBWDW-BXMDZJJMSA-N mevinolinic acid Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@@H](C)C=C21 QLJODMDSTUBWDW-BXMDZJJMSA-N 0.000 title abstract 2
- ZPSJGADGUYYRKE-UHFFFAOYSA-N 2H-pyran-2-one Chemical group O=C1C=CC=CO1 ZPSJGADGUYYRKE-UHFFFAOYSA-N 0.000 abstract 3
- 239000007858 starting material Substances 0.000 abstract 3
- PCZOHLXUXFIOCF-UHFFFAOYSA-N Monacolin X Natural products C12C(OC(=O)C(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 PCZOHLXUXFIOCF-UHFFFAOYSA-N 0.000 abstract 2
- WLAMNBDJUVNPJU-UHFFFAOYSA-N 2-methylbutyric acid Chemical group CCC(C)C(O)=O WLAMNBDJUVNPJU-UHFFFAOYSA-N 0.000 abstract 1
- HTJDQJBWANPRPF-UHFFFAOYSA-N Cyclopropylamine Chemical compound NC1CC1 HTJDQJBWANPRPF-UHFFFAOYSA-N 0.000 abstract 1
- MSZJEPVVQWJCIF-UHFFFAOYSA-N butylazanide Chemical compound CCCC[NH-] MSZJEPVVQWJCIF-UHFFFAOYSA-N 0.000 abstract 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
- HWDVTQAXQJQROO-UHFFFAOYSA-N cyclopropylazanide Chemical compound [NH-]C1CC1 HWDVTQAXQJQROO-UHFFFAOYSA-N 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 150000003839 salts Chemical group 0.000 abstract 1
Landscapes
- Pyrane Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN175DE1997 IN184969B (enrdf_load_stackoverflow) | 1997-01-24 | 1997-01-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW427968B true TW427968B (en) | 2001-04-01 |
Family
ID=11088580
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW086111652A TW427968B (en) | 1997-01-24 | 1997-08-14 | Process for manufacturing simvastatin from lovastatin or mevinolinic acid |
Country Status (2)
| Country | Link |
|---|---|
| IN (1) | IN184969B (enrdf_load_stackoverflow) |
| TW (1) | TW427968B (enrdf_load_stackoverflow) |
-
1997
- 1997-01-24 IN IN175DE1997 patent/IN184969B/en unknown
- 1997-08-14 TW TW086111652A patent/TW427968B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IN184969B (enrdf_load_stackoverflow) | 2000-10-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GD4A | Issue of patent certificate for granted invention patent | ||
| MM4A | Annulment or lapse of patent due to non-payment of fees |