TW426663B - Novel compounds and methods for synthesis and therapy - Google Patents

Abstract

Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.

Description

Printed by the Central Standards Bureau of the Ministry of Economic Affairs, Shellfish Consumer Cooperatives 4 266 6 3 v at ____ B7 V. Description of the Invention (1) Related ... Guan Shen _ 窭: "This case is a US patent application SN 08/580567 (1 9 February 1995), part of the consecutive applications, the aforementioned case is part of the US patent application SN 08/476946 (filed on June 6, 1995), and the previous case is It is part of the US Patent Application Serial No. SN 08/395245 (filed on February 27, 1995), all of which are under review and are incorporated herein by reference. Inventing the summer heat Inventing the jaw domain Neuraminidase (also known as sialidase, aldehyde neuraminyl hydrolase, and EC3. 2. 1. 18) are common enzymes in animals and many microorganisms. It is a glycohydrolase, and sialic acid, which breaks the terminal α-ketosaccharide bonds from glycoproteins, glycolipids and oligosaccharides. Many neuraminidase-containing microorganisms are pathogenic to humans and other animals, including poultry, horses, pigs and seals. These pathogenic organisms include influenza viruses. Neuraminidase is involved in the pathogenic process of influenza virus. It is believed to help the newly synthesized virus particles to escape from infected cells, and to help the virus move through the respiratory mucosa (through its hydrolytic activity).

Itzstein, Μ.νοη et al. * ^ Nature ', 363 (6428): 418-423 (1993) revealed that sialic acid (CNS) Α4 ^ Μ · (210X297 ^) that inhibits influenza virus replication' (please first (闰 Read the notes on the back again t ^ this page)

-4-426663 A7 B7 5. Explanation of the invention (Z) Theoretical design of enzyme-based inhibitors.

Colman, PM, et al .; International Patent Publication No. WO 92/06691 (Int. App. No. PCT / AU 90/00501, published April 30, 1982), Itzstein, LM von, et al .; Europe Patent Publication No. 0539 2 0 4 A 1 (

Ep App · No. 92309684.6, published April 28, 1993), and Itzstein, LM von et al .; International Publication No. VO 91/16320 (Int. App. No. PCT / AU 91/0 0161 (Published on October 31, 1991), reveals compounds that bind to neuraminidase, and claims to have antiviral activity in vivo.谙 Note of reading first Φ

Printed by the Shellfish Consumer Cooperative of the Central Standards Bureau of the Ministry of Economics Purpose of the invention Inhibition of the present invention. In particular, especially the disease, the urination rate of the present invention is sufficient for therapeutic efficacy. The clinical purpose requires pharmacological properties. The main purpose is virus. The other purpose is to inhibit such as toxicity or bacterial ceramides. Oral bioavailability (upper acceptable toxicity curve (especially for influenza virus, selective inhibition of glycosidase hydrolase, neuraminidase). Inhibitors of glutamate, which enter the nose or lungs Secretions with bioavailability) * high profiles) * and others. Another purpose is to propose a better and cheaper synthetic method of neuraminidase inhibitors. Another purpose is to propose the administration of known and novel neuraminidases. Improved method for inhibitors. The paper size is applicable to China National Standards (CNS) Λ4 specification (2! 0 × 29? Mm) 426663, A7 B7 V. Description of the invention (3) Another purpose is to propose for preparation. Polymers, surfactants or immunogens or other industrial processes and articles of composition. These and other objects will be understood by those skilled in the art after considering the present invention. Summary of the Invention The compound or composition of the present case has formula (I) or (π) Ui A ^ U,

Where A 1 is one C (Jr) =, or one N =:. — ≫ — (please read the notes on the back first and then this page) Α2 is —C (JOs—, — N (Ji)-, one Ν (0) (Ji) —, — N (0) =, — S —, -S (0) SC 〇) a —or _ ◦ — Printed by the Consumers ’Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs

OR θ Β,

-NO or-(CR 1 R 1) mlW 2; Τι is -NRiWa, heterocyclic ring * or combined with 111 or 〇1 to form the group shown below: This paper standard is generally Chinese National Standard (CNS) A4 specification (210 X 297 Mm) 4 2 6 6 6 w Λ. Let A 7 B7 V. Description of the invention (4) > ν '; U 1 is Η or -X 6; J! And J are each Ri'Br'Cl, F 'I' CN 'Ν Ο 2 or N 3; J 2 and J 2a are each H or R 1; R i is each Η or C 1 -C 12 alkyl; R 2 is each 3 or 1 ^ 4 each of R 4 Independently substituted by 0 to 3 R3; each R3 is F, C1, Br, I, -CN, N3, -N Ο 2 *-0 R 6a * ~ Ο R 1 * — N (R 1) 2, -N (R!) (R 6b) ·-N (Re eb) 2 · -SRi ， —SRea ， -S (◦) Ri ， -S (0) ZR i > —S (0) ORj ·-S (0) 0Rea * -S (0) 2 0 R!--S (0) 2〇Rea, issued by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs -C (0) OR ^ -C (0) Rec * —C (0) 0Ree, one OC (0) Ri, -N (R!) (C (0) R!), -N (Re eb) (C (0) R!), -N (R! ) (C (0) 0 R!)-—N (Reb) (C (0) 0 R!), -C (0) N (R a) 2-This paper size applies Chinese national standard Standard (CNS) Λ4 specification (210X297 mm) -7-Printed by the shoulder labor consumer cooperative of the Central Standards Bureau of the Ministry of Economic Affairs 4 2 6 6 6 3 A7 __ ^ _ B7_ V. Description of the invention (5) -C (0) N (R eb) (R!), -C (0) N (Reb) 2,-C (NR. (N (Ri) 2), -C (N (Reb)) (N (R!) 2), -C (N (R!)) (N (R i) (Reb)), -C (N (Reb)) (N (R!) (Reb)), -C (N (R!)) (N (R 0b) 2), -C (N (Reb)) (N (R Bb) 2), -N (Ra) C (N (R1)) (N (R!) 2), -NCR ^ CCNCRi )) (N (R!) (Reb)), -N (Ri) C (N (R6b)) (N (R!) 2), -N (Reb) C (N (R1)) (N ( R!) 2), -N (Reb) C (N (Reb)) (N (R!) 2), -N (Reb) C (N (R1)) (N (R r) (Reb)), -N (R1) C (N (Reb)) (N (R!) (R 6b)), -N (R!) C (N (R i)) (N (R 6b) 2) > -N (Re eb) C (N (Reb)) (N (R t) (Reb)), one N (Reb) C (N (R!)) (N (Re eb) 2), -N (R!) C (N (Reb)) (N (Re eb) 2), -N (Re eb) C (N (Re eb)) (N (R 6b) 2), = 0, = 8, = 1 ^ (111 ) Or = 1 "[(1161 >); R4 is each Cl — Ci2 alkyl, C2-Ci2 alkenyl, or c2 — C 1 2 alkyl;

Rs are each R4, and each foot 4 is replaced by 0 to 3 feet 3;

Each Rsa is Ci — C 12 Shen Yuanji ’C 2 — C 12 Shen Jiji, or this paper size applies Chinese National Standard (CNS) A4 specification (2ΐκκ297 mm). — ,, * Order chain (please read the notes on the back before filling this page) 4266 6 3, at B7 Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs 5. Description of the invention (6) 1 1 C 2 "- C 1 2 alkynyl any--alkylene 1 or alkenyl group is substituted by 0 to 1 1 3 R 3 τ 1 IR β β are each Η or an ether or ester-forming group; 1 IR β t > each is a residue of Η y amine protecting group or a carboxyl group-containing compound; please read 1 R Rec is each Η or a residue of an amine-containing compound t read IW i on the back is a group containing acidic hydrogen. Note for protecting acidic groups or containing acidic hydrogen 1 1 R amine group of the group 1 IW 2 is a group containing a basic heteroatom or a protected basic heteroatom, or %% of the writing 4 I This basic heteroatom R β b enzyme amine; Page 1 1 W 3 is W 4 or W 5 1 | W < 4 is R 5 or — C (0) R 5-— c (0) w 5. I — S 0 2 R 5 or _ s 0 0w a; 1 Let IW 5 be a carbocyclic or heterocyclic ring, each of which may be substituted by 0 to 3 R 2 1 1 IW 6 is-R 5-w 5,-R Se W g * 1 1 — C (0) 0 R 6 at — C (0) R, 1 y — C (0) N (R θ b) 2 * h 1 — C (NR eb) (N (R β t >) 2) »1 1 — C (NR eb) (N (Η) (Re 1,))» 1 1 — C (N (Η) ( N (R 6 b) 2) 1 1 I-C (S) Ν (R Θ t >) 2, or C (0) R 2 * 1 1 X 1 is the bond t — -0--, -N ( H)-One N (W β)-1!) — N (0 Η) — i One N (0 W 6)-— N (Ν Η 2)-1 t 9 — N (Ν Η) (W β )) —, -N (Ν (W β) 2)-1 I 1 — N (Η) Ν (We) —, one S — S 0 —, or 1 1 The paper scale is applicable to China National Standard (CNS) A4格格 〖〖〇Χ297mm） —9 — 4 2 6 6 6 3 ^ A7 _B7_ V. Description of the invention (7)-s 〇 2 —; mi each is an integer of 0 to 2; except the following compounds, which (a) Aι is one CH = or one N = and R2 is one CH2_t (b), E1 is COH, P (0) (0H) 2, SOOH, S03H, or tetrazolyl;

(c) GjCN, N (H) R2O, N3, SR20 OR2. , Guanidino, —N (H) CN (Please read the precautions on the back before filling in and writing this page)

NH * N " R2〇 R20R20 CH-

Printed by the Consumer Cooperatives of the Central Bureau of Standards of the Ministry of Economic Affairs (d) Ti is -NHR20: (e) R2. Is H; Ci-C4fluorenyl; Ci-Ce linear or cyclic alkyl, or its halogen-substituted analog: allyl or unsubstituted aryl, or via halogen, OH, N02, 1 ^ 112 or ": 0011 substituted aryl t (f) Ji is Η and Jla is 11 ,? , (: 1, 8]: or CN; (g) J 2 is Η and J 2a is Η, CN or N 3; (h) Ui is CH2YR…, CHYR20 CH2YR… or CHYR20aC HYR2aaCH2YR2Qa: The paper wave scale is applicable to China Standard (CNS) Λ4 specification (210X297 mm) -10-4 2 6 so tD 3 426663, V. Description of the invention (A7 B7 8 (i) R 2〇a is Η or C 1-C 4 醯 group; (j ) Y is 0, S, H or NH; (k) 0 to 2 YR 2oe is H, and (1) each Y part of Ui is the same or different, and when Y is H, then R 2. Is a covalent bond, and if G 1 is N 3 then U 1 is not -CH20 CH2P h > and its pharmaceutically acceptable salts and solvates: and its salts, solvates, and resolved mirror image stereo Isomers and purified non-mirror stereoisomers. Another specific example of the present invention is directed to compounds having the formula:

1a

1a Please read the note on the back lS and bind on this page where E 1 is-(CR 1 R 1) mlW 1; G ^ N3, — CN, — OH, — 0Rea, — N02 — or — (CHhiWz; Τι is one NRiW3, heterocyclic ring, or combined with 1; 1 or 〇1 to form the group shown below: V: This paper size applies Chinese national standards ((:! ^ 5) / \ 4 specifications (210; < 297) Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Spicy Economy 11-426663 ^ A7 B7 V. Description of the invention (

Ui is Η or a XiW6 and if it is -XiWe, Ui is a branched chain • 11 and] 1 & each is R ^ Br, C1'F, I, CN, N 0 2 or N 3; each of J 2 and J 2a Is Η or R 1; Ri is each Η or Ci-C12 alkyl; R 2 is each R 3 or R 4, where each R 4 is replaced by 0 to 3 R 3 Please read the note above 4 Ministry of Economic Affairs The Central Bureau of Standards, Consumers and Cooperatives printed R3 for F, C1, Br, I, one CN, N3, —N〇2, — ORea, one ORl, _N (Ri) 2., -N (R!) (Reb), — N (Reb) 2--SRa--SRea · — S (0) Ri, -S (0) 2R! · -S (0) 0 R! *-S (0) 0 R 6a > -S (0) 2 0 R! ≫-S (0) 20 R ea 1 -C (0) ORr-C (0) Rec, -C (0) 0Rea--0C (0) Ri · -N (R!) (C (0) R1)--N (R 6b) (C (O) Ri), -N (R 1) (C (0) 0 R!), N (Reb) (C (0 ) 0 R i)

) to 1 Θ 6 \ ly RΡίRΘ (((R N N N (Λ—y Nly \ ly No o o (/ (V / lx / lx c c c c I

R / IV N -fv 2) 1 RN / | \) »1 -xly RNN \ J. X t (R \ 1 / c xfv 1 This paper size applies to the Chinese National Standard (CNS) Λ4 specification (210X 297 mm) Page-12-4266 6 3 A7 B7

V. Description of the invention (printed by 1G Men ’s Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs-C (N (Ri)) (N (Ri) (Reb)), -C (N (Reb)) (N (R!) (R ei >)), -C (N (R!)) (N (R Bt >) 2), -C (N (Re eb)) (N (Re eb) 2), -N (R 1) C (N (Rx)) (N (R!) 2)--N (R1) C (N (R1)) (N (R a) (R 6b)), -N (R 1) C (N ( Reb)) (N (R!) 2), -N (R6b) C (N (R1)) (N (R!) 2), -NCR Bb) C (N (R 6b)) (N (R ( !) 2), —N (Reb) C (N (R!)) (N (R x) (R 6b)) -N (R1) C (N (Reb)) (N (R!) (Re eb )) -N (R1) C (N (R1)) (N (R 6b) 2), -N (R 6b) C (N (Reb)) (N (R i) (Reb)), -N ( Reb) C (N (Ri)) (N (R6b) 2), -N (R1) C (N (RSb)) (N (Reb) 2), ~ N (R6b) C (N (R 6b)) (N (Reb) 2), = ◦, = S, = N (RiM = N (Reb): R4 is C i — c 12 courtyard base, c 2 — c 12 storage base, or C2 * ~

C 1 2 block basis; R 5 is each R

R Please read the notes of the back again and each R 4 is substituted by 0 to 3 R 3; each is Cl— (: 12-alkylene, c2-c12-alkenyl • or c 2-C 12-alkynyl And the alkynyl group is replaced by 0 to 3 R 3; each Rea is a fluorene or an ether or ester-forming group: each is a fluorene, an amine protecting group or a residue containing a carboxyl group; this paper size applies Chinese National Standard (CNS) Λ4 Specification (210X 297 Gm) 13 426663 A7 B7 Printed by the Shellfish Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs 5. Description of the Invention (11) R β. Each is a residue of fluorene or an amine-containing compound W i is a group containing acidic hydrogen, a protected acid group, or a R ec amine group containing an acidic hydrogen group, W 2 is a group containing a basic heteroatom or a protected basic heteroatom, or the Reb amines of basic heteroatoms; W 3 is W 4 or W 5 »W 4 is R 5 or -C (0) R s, -C (0) W 5 -S 0 2 R 5 or —S 0 2W 5; W 5 is a carbocyclic or heterocyclic ring, wherein R 5 is each substituted by 0 to 3 R 2 »W 6 is an RS, -W 5 > -R 5aw 5 * — C (0) 〇R 6a, one C (0) RB c 1 — C (0) N (R Θ) 2 τ — C (NR 6b) (Ν (R β t >) 2), — C (S) N (R 6b) 2 7 or C (0) R 3 X i is a bond,-〇—, -N (Η)-, -N (W 6)-> — N (0 Η)-*-Ν {0 ^ "6)-,-N (Ν Η 2)-, — N (N (Η) (We)) — > -N (N (We) 2) — > — N (Η) N ( we)-»-S —, —SO—, or S 0 2 —» mi are each an integer of 0 to 2; and its salts, mediates, resolved mirror-image stereoisomers and purified non-mirror image stereoisomers 〇 Another specific example of the present invention is for compounds with the following formula: The size of the paper used in the book is applicable to the Chinese National Standard (CNS) Λ4 specification (210X297 mm). Please read the precautions on the back first. 2 6 6 6 3. A7 B7 V. Description of the invention (12

J1a where El is _ (CRiRijmiWi, Gi is N3, one CN, -OH,-0Rea,-N03, or-(CHUr, Ti is -NRiW3, heterocyclic ring, or combined with Ui or Gi to form a lower group: > Please read the precautions on the back and order R6b-N on page I;

Ui is Η or ~ XiWe; 11 is] 1 £ 1 is 1 ^ 1 each: 81 ', (: 1, 卩, 1'01 ^, Ν Ο 2 or N 3; J 2 and J 2a are each Η or R t; Ri are each Η or Ci — C12 alkyl: R2 is 1 ^ 3 or 1 ^ 4 each of which is replaced by 0 to 3 feet 3; This paper size applies Chinese National Standard (CNS) Λ4 specification (210X 297 mm)-15-426663 A7 B7 Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs 5. Description of Invention (I3)-R 3 is F, C 1 · B r-I, 1 CN, N 3 ' — N 0 2 9-~ ORea * — ORiT--N (R 1) 2, — N (R 1] (R eb), — N (R 6b) 2 * -SR i > — SR 6 & 9 -S (0) R j-S (〇) 2 R! I — S (0) 0 R!--S ¢ 0) 0 R 6 & * — S (0) 2〇R1, one S (0) 2 〇R 6a '— C (0) 0 R!--C (0) RBC * r C (0) 0 R ea ·-0 C (0) R i-— N (R 1) (C (0) R a), — N (R β b) (C (0) R 1 '), — N (R 1) (C (0) 0 R x), — N (R 6 b) (C (0) 0 R!) ≫ — C (0) N (R!) 2, — C (0 ) N (Re eb) (R i), — C (0) N (R 0b) 2 *-C (NR!) (N (R!) Z) ♦ — C (N (R eb)) (N ( R a) 2), — C (N (R x)) (N (R a) (R 6 b)), — C (N (Reb)) (N (R x) (Reb))) »— C (N (R i)) (N (Re eb) 2), — C (N (R 0b)) (N (Re eb) 2) * — N (R!) C (N (R!)) ( N (R i) 2), — N (R 1) C (N (R a)) (N (R!) C R- θ t >)), — N (R!) C (N (Re eb) ) (N (R!) 2), one N (R θ b) C (N (R!)) (N (R!) 2), this paper size applies to China National Standard (CNS) A4 specification (210X297 mm ) 16 16663

R

C Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economy A7 B7 V. Description of Invention (Η) -N (R 6b) C (N (Rab)) (N (R x) 2), -N (Reb) C (N (R!)) (N (Ri) (R 6to)) ~ N (R1) C (N (R6b)) (N (Ri) (R ab)) -NCR ^ CCNCR!)) (N (Re eb) 2), -N (R 6b) C (N (Reb)) (N (R!) (Reb)) --N (R0b) C (N (R1)) (N (Reb) 2), -N ( R x) C (N (Reb)) (N (Reb) 2), -N (R 6b) C (N (Ret >)) (N (Reb) 2), = 〇, = S, = N (Ri) or = N (Reb); R4 is Ci-C12 alkyl, C2-C12 alkenyl, or c2-C1 2 fast group; R5 is R4, and each 4 is 0 to 3 R3 Substitution;. Each is Cl — C 12 alkynyl, C 12 alkynyl, or -c12 alkynyl, and the alkynyl is substituted by 0 to 3 R3: each Rea is fluorene or forms an ether or forms an ester Each R is a residue of fluorene, an amine protecting group or a carboxyl group-containing compound; each of R is a residue of fluorene or an amine-containing compound;

Wi is an acidic hydrogen-containing group, a protected acidic group, or a Rec amine group containing an acidic hydrogen group; Heteroatomic R0b amide; W 3 is W 4 or W 3; double 4 is ruler 5 or —C (0) Rs,-C (0) W5, one S O2R5 or one S 02W5; private paper size is applicable to China Standard China (CNS) A4 size (210X 297 mm) (Please read the precautions on the back before filling the nest ^ > gt)

-17-426663 A7 B7 V. Description of the Invention (IS) W5 is a carbocyclic or heterocyclic ring, in which Rs are each substituted by 0 to 3 feet 2,

Wj-R5, — W5, -R 5eW 5, -C (0) 0Rea, — C (◦) Rae, —C (Ο) N (Reta) 2, -C (NR eb) (N (R 6b) 2 ), -C (S) N (Reb) 2 * or C (0) R2;

Xj— Ο —,-N (H)-,-N (We)-, -N (OH) —, -N (0 W 6)->-N (NH z)-> -N (N ( H) (We)) -'- N (N (W6) 2)-, one N (Η) N (We)-, one S —, one SO —, or —S 0 2 — > nil each is 0 An integer of 2; and its salts, solvates, resolved mirror-image stereoisomers and purified non-image mirror-stereoisomers. Another specific example of the present invention is for compounds with the following formula: Please read the notes on ιδ before reordering the printed uXr Ει from the Consumer Cooperatives of the China Standards Bureau of the Ministry of Economic Affairs, where G1 is a paper standard that applies the Chinese National Standard (CNS) A4 specification 210 × 297 mm) -18-426663 4 A7 __B7__ Five 'invention description (16) 01 is -NH2, -N (H) (115) or -N (H) (C (N (Η)) (Ν Η 2 )); Ti is-Ν (Η) (C (Ο) C Η 3); U 1 is -0 R β 〇, ruler 1 is 1 ^ or has 1,2,3,4,5,6,7, Alkyl groups of 8, 9, 10, 11 or carbon atoms; R β. Is a branched alkyl group having 3, 4, 5, 6, 7, 8, 9, 10, 1 1 or 12 carbon atoms; and salts, intermediates thereof, which have been resolved as stereoisomers and purified Mirror stereoisomers. -Another specific example of the present invention is directed to compounds of formula (νπ) or (vm):

Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economics where E 1 is-(C H) ralW!;

Gi is Ν3 · -CN, -OH, -ORaa, -NO〆 or-(CRiRJdWs: Ding 1 is -NRiW3, heterocyclic * or combined with Gi to form the group shown below. The paper dimensions are applicable to Chinese National Standard (CNS) · 4 grids (210X297mm) -19-426663 A7B7 Printed by the Consumers' Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs 5. Description of the invention (Π) &y; U 1 is a X 1 W 6; J! And J 1 a each R 1 ^ B r C 1 * F, I, CN, N 〇 2 or N 3, J 2 and J 2 a are each H or R 1 1 R 1 is each H or C i _ c 1 2 alkyl; R 2 is each R 3 or R 4, where each R 4 is 0 to 3 substituted by R 3 1 each R 3 is F, C 1, B r »I, one CN, N 3, N 0 2 1-〇 Rea, —0 R!---N (R i) 2 * — N (R 1) (R Θ b), — N (R 6 t ») 2 > -SR! ≫ — SR Θ a * One S (0) RL * — S (〇) 2r 1 * — S (0) 0 R l, one S (0) 0 R- 6 a 1 One S (〇) 2 0 R! * -S (〇) 2 〇R ey — C (0) 0 R l, _ C (0) R 0 C * — C (0) 0 R ea * -0 C (0) R! ≫ — N (R 1) (c (0) R 1), — N (R β b) (c (〇) R!) T — N (R!) (C (0) 〇R!) ≫ — N (R 0 b) (c (0) 0 R!) F — C (0) N (R 1) 2 f Please read the note at the back and then 4 m This page applies the national standard (CNS) Λ4 specification ( 210X297 mm) -20 1 4 266 6 3 Printed by the Consumer Cooperatives of the Central Bureau of Standards of the Ministry of Economic Affairs 11 ^ A7 __B7_ V. Description of the invention (18) -C (0) N (Reb) (R 1), -C ( 0) N (Ret >) 2, -C (NRi) (N (R!) 2), -C (N (R0b)) (N (R!) 2), -C (N (R!)) CN (R!) (R ab)), -C (N (Re eb)) (N (R!) (R 6b)), -C (N (R x)) (N (Re eb) 2),- C (N (Reb)) (N (R 6b) 2) > -NCR ^ CCNCR ^) (N (R!) 2), -N (R1) C (N (R.1)) (N ( R α) (Reb)) * -N (Ri) C (N (R0b)) (N (R!) 2), -N (R6b) C (N (R1)) (N (R!) 2) , -N (R 6b) C (N (R 6b)) (N (R!) 2), -N (Rab) C (N (R1)) (N (R!) (Reb)), -N (R \) C (N (Reb)) (N (R!) (R 6b)), -N (R1) C (N (R1)) (N (Reb) 2), -N (Reb) C (N (R 6fc >)) (N (R !) (Reb)) * -N (Reb) C (N (R1)) (N (Reb) 2), -N (R a) C (N (Reb)) (N (R 6b) 2), -N (Reb) C (N (Reto)) CN (Reb) 2), = 0 or = N (Reb); R4 is Ci-C12 alkyl, C2-C12 alkenyl, or C2-C i 2 alkynyl: R 5 is each R 4, and each R 4 is substituted by 0 to 3 R 3: R 5 & each is Ct—C12 alkylene, C2-C12 alkylene, or (Please read the back first (Notes on this page)

, 1T This paper scale is applicable to the Chinese National Standard (CNS) A4 specification (2! 0 × 297 mm) 21 Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs 4 2 6 6 6 3 «4 A7 _B7_ V. Description of the invention (l9). c2 — c 12 alkynyl 'any alkynyl' or alkynyl group is replaced by 0 to 3 R 3: R6e each is a fluorene or an ether or ester-forming group; each R is a fluorene, an amine Residue protecting groups or residues of carboxyl-containing compounds; Rec each is a residue of fluorene or an amine-containing compound; Wi is an acidic hydrogen-containing group, protected by an acidic group 'or R β < = 醯Amine group; 诹 2 is a group containing a basic heteroatom or a protected basic heteroatom, or R 8b amine of this basic heteroatom; W 3 is W 4 or W 5; W 4 is chi 5 or 1 ( : (0) Rs, a C (0) W5, —S 03R5 ^ — S 02W5i Ws is a carbocyclic or heterocyclic ring, wherein R5 is each 0 to 3 substituted by R2 t W β is —R5, — W5 '— R 5 < aW 5, -c (0) 0R6a > -C (0) Re〇 * -C (0) N (Reb) 2, -C (NR eb) (N (Reb) 2) '-C ( NR efa) (N (H) (Reb)) '-C (N (H) (N (Reb) 2), -C (S) N (Reb) 2, or C (〇) R 2 Xt is a bond, one 0 —, one N (H) —, one N (We)-—s — s ο-, or one s ο mi is an integer from 0 to 2: Private paper scales apply to China Standard (CNS > Λ4 specification (210X297mm) (Please read the precautions on the back before filling in the title page) Binding and Binding -22-4 2 6 6 6 3 4 A7 ____ B7 V. Description of the invention (20) However, it does not include compounds whose 111 is 11 or —ch2ch (OH) ch2 (Η ；); and salts, intermediates, resolved mirror-stereoisomers and purified non- mirror-stereoisomers. Another aspect of the present invention In a specific example, the compound or composition further comprises a pharmaceutically acceptable carrier. In another specific example of the present invention, a method containing a method for treating a sample that may contain a neuraminic acid M enzyme with the compound or composition of the present invention is used. Inhibition of neuraminidase activity. Another embodiment of the present invention proposes a method of inhibiting neuraminidase activity, which includes a step of contacting a sample that may contain neuraminidase with the composition of the present invention. Another specific example is the treatment or prevention of viruses (especially influenza viruses) in the host A method of infection, which comprises administering to the host a topical application to a path outside the respiratory tract, a therapeutically effective amount of an antiviral as described in WO 91/16320-WO 9 2/06691 or US Patent 5 3 6 0 8 17 Compound. . Consumption Cooperation by Employees of the Central Bureau of Standards and Commerce of the Ministry of Economic Affairs. In other specific examples, a novel synthetic method of the compound of the present invention β is proposed. In this example, compound 2 8 1 is used, that is, this method involves compound 2 8 1 and As shown in formula R5— Xi-Η, the compound reacts to form compound 2 8 1.1: 23-The size of the paper is applicable to the Chinese national standard (0 ~ 5) 8 4 specifications (21〇 < 297 mm) 266 6 3 A7 B7 V. Description of the invention (21 of which N3 281

CO2R51 X 1 and R 5 are as defined above; R 51 is the acid stable protecting group of carboxylic acid; R 54 is aziridine activating group. Another specific example proposes a method using a compound having the formula '

(Please read the precautions on the back before filling in this page). Packing. Cinchona acid This method includes treating cinchona acid with geminal dialkoxide or pandoxal naphthene and acid to The following compounds are formed:

274 Treatment of compound 2 7 4 with metal alkanolate and alkanol to form the compound shown below: This paper size is applicable to China National Standards (CNS > A4 size (210X297 mm) line 丨-. Staff Consumption of Central Standards Bureau, Ministry of Economic Affairs Printed by the cooperative -24-426663 A7 B7 V. Description of the invention (22

R OH 5 (Κ 〇W.

CO2R51 OH 275 Treated compound 2 7 5 with sulfonium halide and amine to form the compound shown below

R OH 5 (Κ 〇, ',.

OR52 276 C02Rsi and

And the compound 2 7 6 is treated with a dehydrating agent, and then treated with an acid and an alkanol to form the compound shown below: ho々,. ^^ co2r51HO, 'V Among them, the Ministry of Economic Affairs, the Central Standards Bureau, the Consumer Cooperative, printed OR 272 R 5 . Is a 1,2-diol protecting group; R51 is an acid stable protecting group of a carboxylic acid; R 5 2 is a hydroxyl activating group. 52 Schematic illustrations Figures 1 and 2 show the arterial oxygen saturation (S a 0 2) in mice infected with influenza A. The mice were subjected to the following doses of various i.p (please read the (Notes again iw this buy)

This paper size is applicable to China National Standards (CNS) A4 (21 ο X 297 mm) -25-2 6 6 6 .3 A7 B7 Printed by the Consumer Cooperatives of the Central Bureau of Standards of the Ministry of Economic Affairs. 5 1 Description of Invention (23) 1 | compound treatment; GG 1 6 7 (4 -guanidino — 2 1 4 —dideoxy —. 1 1 f 2, 3 —dehydro-N —acetamidinyl neuraminic acid) which is a known anti- Stream 1 1 line of influenza virus compounds (Mr. 1 | BJ.I picture) t Chemical compounds of the invention 2 0 3 (V 1 I Please 1 I picture 2); 5 0 > 1 0 2 and m each P k (m 8 / kg / first 1 I 1 1 day) of the test compound and the over-water control group 9 | Wt in the figure are square * solid back 1 to 1 circle, triangle, rhombus and hollow chart In the picture * Compared to salt, note 1 1 thing 1 water control group S * P < 0. 0 E) »* < 0. 0] L 0 term 1 Λ 1 3rd 5th comparison in influenza A sense % S1 0 a 2 in mice, each of which was treated with P. 0. Dose of riazole (r 1 bav ir in) (bi 1 / * 3 form), compound (square) »? ≫ r * Xing GG 1 6 7 (filled circle) treatment 9 1 1 Saline control group is a hollow circle. Figure 3 Compounds 2 0 3 and 1 1 GG 1 6 7 is 1 5 0 m P k Ribozole is 1 0 0 m P k Order No. 4 [Figure: Compound 2 0 3 and GG 1 6 7 are 50 m P k »Ribozole is JI 3 2 m ρ k: Figure 5 Compound 2 0 3 rfrt and GG 1 6 7 are 1 I 1 0 τη pk, ribavirin is 10 m P k 〇1 1) Lines 6-8 are S a 0 2 1 1 of mice infected with influenza A A »Each of them was treated with a low P · 〇 dose of compound 2 6 2 (round) and 1 1 2 6 0 (filled square) and GG 1 6 7 (triangle) treated with saline 1 1 The control group was a hollow circle, while the infection control group was a hollow square 0 Fig. 6; each 1 1 The test compound is m ρ k 7th rwt circle: each alpha It is 1 m P k 1 |, Figure 8 • Each test compound is 0 * 1 m P k 9 1! I Detailed description I tf ψ Specified composition 1 1 This paper size is applicable to China National Standard (CNS) A4 specification (210X297 (Mm) 426663 A7 B7 Printed by the Central Laboratories of the Ministry of Economic Affairs and Consumer Cooperatives V. Description of the invention (24) The compounds of the present invention do not include the known ones. But it can be seen in other specific examples below. As can be seen, the use of known compounds previously known only as intermediates of antiviral compounds for antiviral purposes is also within the scope of the present invention in the United States. The compounds or compositions in this case do not include 3 5 USC § 1 0 2 preemptive compound or 3 5 USC § 103 obvious and easy-to-understand compound ○ Special * This patent request excludes W 0 9 1/1 6 3 2 0 W 0 9 2/0 6 6 9 1, US patent 5 3 6 0 8 1 7 or Chand 1 ert M. * et al .; JL Chem. Soc. Perk i η Τ ran s. \] L 9 9 5 1 189 -1197 However, a specific example of the present invention includes compounds within the scope of W 0 Θ 1/1 6 3 2 0 > W 0 9 2/0 6 6 9 1 or U.S. Patent 5 3608 17 With formula (a) in case (a) 3 2 0, plant A j in case (b) ^ 3 2 0 is carbon * and (c) / 3 2 0 and 1 6 9 1 in case R 5 & Γ-CHZYR6 ·-CH YR eC Η 2 YR 6 or CHYR6CHYRe C Η 2Y R 6 J where Y R 6 cannot be 0 Η or protected OH (the protective group can be hydrolyzed to white 〇 Η in the human gastrointestinal tract), that is, this compound is hydrolytically stable in the gastrointestinal tract. Therefore, the compounds excluded by the tariff system are those in the case of 3 2 0 or-6 9 1 where R 5 is ethenyl or other C t -C 4 carbofluorenyl. Methods for determining the stability of compounds in alternative gastrointestinal secretions are known. The so-called gastrointestinal-stabilizing compound refers to a deprotected protective base of less than about 50 mol% after incubation in intestinal fluid or gastric fluid for 1 hour at 37 ° cm. Such compounds are suitable for use in the above specific examples. 0 should be noted in the gastrointestinal " binding micro-please 4 notes on reading and reading again i -27-A7 B7 printed by the Consumer Cooperatives of the Central Bureau of Standards, Ministry of Economic Affairs, unsubstituted pyrimidyl group , Or 4266 6 3 V. Description of the invention (25). The compound of Daoxan does not mean that it cannot be hydrolyzed in the body. Generally, prodrugs are stable in the digestive system, but they are hydrolyzed into parental drugs in the digestive cavity, liver or other metabolic organs, or in general cells. However, it should be understood that the specific examples of the application of other compounds of the present invention detailed below are those shown in WO91 / 16320, WO 92/0 6 6 9 1 or US Patent 5 3 6 0 8 1 7 Its YR 8 is a free hydroxyl group or a hydroxyl group protected by an easily hydrolyzable group (such as acetamyl). In this case, however, these compounds are used by novel routes of administration. In another specific example, the compound of the present case excludes the following: (a) Eι is a C02H * -P (0) (OH) 2 · —N02, a S02H, a S03H, a tetrazolyl group, -CH2CHO , A CHO, or -CH (CHO) 2: (b) G i is -CN, N3,-NHR2O, NR20, -0R2O, guanidino, SR2O, -N (R2O)-ο , -N (r20) (〇r20), -N (H) (R20) N (R 2〇) unsubstituted (pyrimidinyl) methyl; (C) Ti is -NHR20, -N02; and R2〇 is Η; Ci-c4 醯 group; Cl-Ce linear or cyclic alkyl group, or the like substituted by halogen; allyl or unsubstituted aryl group, or by halogen, OH, N02, NH2 or COOH Substituted phenyl groups; (d) Each J 1 is Η: This paper size is applicable to Chinese National Standard (CNS) Λ4 specification (210 × 297 mm) (Please read the precautions on the back before filling this page)

—28-4 266 6 3 v A7 _______B7 _ V. Description of the invention (26) (e) χι is a bond, a CH2- or a cH2CH2-; in this example, We is not Η, WT or a Cii2W7, where W7 is Η »— 0 R 6a? — 〇R,-N (R 1) 2, — Ν (R 1) (Reto) 9 N (Retl) 2, one SR, or — SR β Β 〇L In a specific example, the compound of the present invention is not C — 20 Η, — C Η 2 0 J 1C or a CH2〇i C Η 2 P h-»In another-specific example, the compound of the present invention is E 1 * is not-C Η 2 0 Η, a C Η 2 OTMS, or -CH 0 〇 In another-specific examples * the compound of the present invention is that U 2 is not directly linked to the central nuclear ring via a carbon atom, Or Ui is not substituted by a hydroxyl group or a hydroxy ester. In particular, U 1 is not a polyhydroxyalkane, especially —C Η (ο Η) C Η C 0 Η) C Η 2 0 Η. In another specific example, U i is a branched chain ^ »R 5 as described below or a carbocyclic ring substituted with at least-5 R 5. In another specific example, the present invention excludes compounds having the formula: XX υΊ // ,, .A2 E, χχ s, Gi (V) (VI) where • 1 is in formula (V); the central standard of the Ministry of Economic Affairs The bureau ’s consumer co-operatives lost A2 to —◦—or—CH2;

Ει is a COjjH

Gi is-N (H) (C (N H) (N H 2)):

Tj— N (H) (Ac); This paper size applies Chinese National Standard (CNS) Λ4 specification (210XN7 mm) -29-4 266 6 3 Λ V. Description of invention (π) U 1 has the following formula: A7 B7

OH 0H or

HO 2. In the formula (V): A2 is —0— or a CHa; E! Is —C02H; G 1 is —N Η 2; Ti is —N (H) (Ac); Uj-CH2OH; 3. In formula (V): A2 is a CH2—El is a CH2OH or —CH2OTMS G i is a N 3, Tj—N (H) (Ac); Ui is —CH2 0CH2Ph; 4. In the formula ( V): Please read the introductory matters before filling in the Irf page. The printout of A2 is a C 负 Ει is a C02H or -C02CH G 1 is -N 3; Tj-N (H) (Ac); U i is -C Η 2 Ο H; 5 In formula (V): A2 is a ch2—: 2 3 This paper size applies the Chinese National Standard (CNS) Λ4 specification ( 210 X 297 mm) -30-Printed by the Consumer Cooperatives of the Central Bureau of Standards of the Ministry of Economic Affairs Α7 Β7 λ ^ 2666 ^ W s- / V. Description of the Invention (28) ^ £ 1 is-<: 〇2 ^ 1 * — CHO, or _CH20Iί: G 1 is -N 3; is a N (H) (Ac); TJ 2 is a CHzOCHgPh '6. In formula (VI): a2 is —ch2—; E 1 is a C 〇 2 Η; G: i is 〇CH3; Ding Zhi is Ν Η 2; U! Is a C Η 2 〇Η; 7. In formula (VI): · A2 is —ch2—; E 1 is -C Ο 2 Η;

Gi is -OCH3;

Tj-N (H) (Ac):

Ui is a CH2OAc. ·

When the compound in this case is substituted multiple times by the same group (for example * "Ri" or rD Θ ^ j), it should be understood that the groups may have the same or & gastric meaning, that is, they are selected individually. "Heterocycles" are included herein as examples, but not by way of limitation, Paquette, Leo A .; Principles of Modern Heterocyclic Chemistry ^ (WA Benjamin, New York, 1 968), especially Nos. 1, 3, 4, 6, 7 , Chapter 9 " The

Chemistry of Heterocyclic Compounds, A series of This paper size is applicable to the Chinese National Standard (CNS) Λ4 specification (2 [OX297 mm) ~ (Please read the precautions on the back before filling in, clothing page) Thread. -31-Economy Du Yinshu of the Central Bureau of Standards, Ministry of Standards and Consumer Affairs, Du Yinhuad 2 6 6 6 3 v 1 A 7 ···-... .. ..., .. _ ... ____. ·..-.... .... il · ./. ·-.. .. ..... ····-· ............. -........ B7... _. _ V. Description of the Invention (29)

Monographs ^ (John Wiley & Sons, New York, 1 950 to date Soc, ", 82:55 6 6 (1 960). Heterocycles include, by way of example and not limitation, pyridyl, thiazolyl, Tetrahydrothiophenyl, thiooxidized tetrahydrothiophenyl, pyrimidinyl, furanyl, blindphenyl, pyrrolyl, pyrazolyl, imidazolyl, tetrazolyl, benzofuranyl, azafluorene subunit, Vermidoyl, pyrene, isoquinolinyl, benzimidazolyl, hexahydropyridyl, 4-hexahydropyridone, pyrrolidinyl, 2-pyrrolidinyl, pyrrolinyl , Tetrahydrofuranyl, tetrahydroquinolinyl, tetrahydroisomurolinyl, decahydroquinolinyl, octahydroisoquinolinyl, azocinyl, triple well, 6H-1, 2, 5- Stilbene, 2 fluorene, 6H-1,5,2, stilbene, thienyl, fluoranthene, piperanyl, isobenzofuranyl, fluorenyl, imidazolidinyl, imidazolinyl, pyridine Oxazidinyl, pyrazolinyl, hexahydropyridinyl, indolinolinyl, isoindolinyl, π-quinidyl, morpholinyl, oxaziridinyl, benzotriazolyl, benzoisoxamine Azolyl'oxindole, benzene Oxazolinyl and isatinoyl. The examples are not limiting, carbon-bonded heterocycles are bonded at the 3, 4 '5 or 6 position of pyridine, and 3, 4, 5, or 6 position of the trap , 2 '4, 5 or 6 position of pyrimidine, 2, 3, 5 or 6 position of pyrimidine, furan, tetrahydrofuran, thiofuran, sleep phen, Btt or tetrahydropyrrole 2, 3, 4, or 5 Position, 2, 4, or 5 positions of oxazole, imidazole or doxazole, position 3, 4 or 5 of isoxazole, pyrazole or isoprazole, position 2 or 3 of aziridine, position 2 of aziridine , 3 or 4 position, 2,3,4,5'6,7 or 8 position of quinoline, 1,3,4,5,6 * 7 or 8 position of isoquinoline. More specifically, carbon bond The heterocyclic ring includes 2-pyridyl, and the scale of Zhang's is applicable to the Chinese National Standard (CNS) A4 specification (2! 0X297 mm) " (Please read the precautions on the back before filling in 页 ν page) -Ί · Order-line -32-A7 B7 Printed by the Central Standards Consumers ’Cooperative of the Ministry of Economic Affairs 426663 V. Description of the invention (30) 3-pyridyl, 4-pyridyl '5-pyridyl, 6 ^ pyridyl' 3 -datra well, 4-da wells, 5-da wells, 6-da wells 2-'pyrimidinyl, 4-pyrimidinyl, 5-pyrimidinyl '6-pyrimidinyl' 2-pyrazinyl, 3-pyridyl, 5-pyridyl, 6-pyridinyl, 2-blazole Group, 4-oxazolyl or 5-PSazolyl. Examples are not limited. • Nitrogen-bonded heterocycles are bonded to aziridine, azetidine, pyrrole, pyrrolidine, 2-pyrroline, and 3-pyrrole. Command 'imidazole, imidazolidine, 2-imidazoline, 3-imidazoline, pyrazole, pyrazoline, 2-pyrazoline, 3-pyrazoline, hexahydropyridine, hexahydropyridine, indole, indole Porphyrin, 1 position of 1 gadolinium-earnidazole, 2 position of isowormworm or isoindolin, 4 position of morpholine, 9 position of oxazole or yS-carboline. More specific oxygen-bonded heterocycles include 1-aziridine, 1-azetidin, 1-pyrrolyl, 1-imidazolyl, 1-pyrazolyl and 1-hexahydropyridyl. As used herein, "alkyl", unless otherwise specified, refers to a Ci-C12 hydrocarbon group containing normal, secondary, tertiary, or ring carbon atoms. Examples are methyl (me, —C Η 3) 'ethyl (Et, -CH2CH3), 1 -propyl (n-Pr' n-propyl, -CH2CH2CH3), 2-propyl (i_Pr, isopropyl ' —CH (CH3) 2), 1 monobutyl (η — Bu, n-butyl '-CH2CH2CH2CH3), 2 — methyl — 1 monopropyl (mono BU, isobutyl, CH2CH (CH3) 2), 2 — Butyl (s — B u, second butyl'-CH (CH3) CH2CH3), 2-methyl-2 to propyl (丄 -Bu, third butyl, _c (CH3) 3), 1 1-pentyl group (n-pentyl'-CH2CH2CH 2 C Η 2 C Η 3), 2-pentyl paper scale it Caiguanjia County (CNS) secret (2iGx297 ^ &)-------- -33-426663 A7 B7 V. Description of the invention (3i) group (1-CH CCH 3) CH 2C H 2C Η 3), 3-pentyl (-CH (CH2CH3) 2), 2-methyl-2-butyl (Mono-C (CH3) 2CH2CH3), 3-methyl-2-butyl (mono-CH (CH3) CH (CH3) 2), 3-methyl mono-butyl (mono-CH2CH2CH (CH3) 2), 2 —Methyl- 1-butyl (mono-CH2CH (CH3) CH 2 CH a), 1-hexyl (mono-CH2CH2CH2CH2CH2CH3), 2--hexyl (mono-CH (CH3) CH2CH2CH2CH3) '3-hexyl (—CH (CH2CH3) (C Η a C Η 2 C Η 3)), 2-methyl-2-pentyl (-C (CH3) 2CH2CH2CH3), 3-methyl-2-pentyl (-CH (CH3) CH (CH3) CH2CH3), 4-methyl- 2-pentyl (mono-CH (CH3)

CH2CH (CH3) 2), 3-methyl-3-pentyl — (— C (C Η 3) (CH2CHa) 2), 2-methyl-3—pentyl (_ Please read the Note: Please fill in page A and order CH (CH2CH3) CH (C Η a) 2 3 Dimethyl (1-C (CH 3) 2C H (CH3) 2), 3,3 dimethyl-2 —butyl (—CH (CH3) C (CH3) 3). Examples of alkyl groups are shown in Tables 2 — 5, 7, 9 and 100-3 9 9 〇 The composition of the present invention includes a compound having one of the following formulas: The paper size applies the Chinese National Standard (CNS) A4 specification (2I0X297 mm) -34 — 4 2 66 6 3 at _______________B7 V. Description of the invention (32)

In a typical hip case, a compound of formula I is used. Each is Ri, Br, Cl, F, I 'CN' No. 2 or N3, typically 'is Ri or F, more typically Η or F, and more preferably Η. : 12 and] 28 are each 1 ^ or 1 ^, typically 11. A: l is one C (Ji) =, or one N =, typically one C (Ji) =, more typically —CH = »eight 2 is —CCJOa-, — N (Ji), -N (Ο) (Ji)-*-N (0) = > -S- · The shellfish consumer cooperative of the Central Standards Bureau of the Ministry of Economic Affairs prints one S (0) —, one S (Ο) 2 — or one 0 —, typically — C (Ji) 2— '-N (J. 1) —, -S — or 101, more typically a C (J l) 2—' or 10 — * _ is more typically _ 匚 112 — Or a 0 —, more typically a ch2- * Ει is — (CRlRl) mlWi. Typically, -C12 alkyl 'is usually H or C1-(: 4 or (; 5 _ (: 1.alkyl' is more typically fluorene or has 1,2'3,4,5,6,7,8, 9,10, 11 or 12 carbon atoms alkyl 'is more typically fluorene or Ci-c3 alkyl selected from methyl'ethyl' n-propyl and isopropyl "The most typical R ^ H a_ This paper Again applicable to the Chinese national standard (CNS > A4 specification (210X297 mm) 426663 A7 * B7 V. Description of the invention (33) m 1 is an integer from 0 to 2, typically 0 or 1, more typically 0 · m2 is An integer from 0 to 1. m3 is an integer from 1 to 3. is an acidic hydrogen-containing group, a protected acidic group, or an R amine group containing an acidic hydrogen group, which means herein that it has a The hydrogen atom is removed to produce an anion or a group corresponding to a salt or a hydrate. The general principle of the acidity or basicity of organic substances is well known, and this defines the boundary 1, which is not described in detail here. However, please refer to Streitwieser , A. and Heathcock, C. Η .; 'Introduction to Organic Chemistry, Secocnd Edition ^ (Macmi1lan, New York, 1981), pages 60 to 64. Generally, the acidic base of the present invention is pk Size, and is usually lower than Pk = 10, more preferably lower than pk = 8, and most preferably lower than pk = 6. It includes tetrazole and carbon, sulfur, phosphorus and nitrogen acids, typically carboxylic acid, sulfuric acid, sulfonic acid , Sulfinic acid, phosphoric acid and phosphorous acid, and R 6 of these acids. Amido and R esters (R ^ and Rec are defined as follows) * Examples of W 1 are -C 0 2 Η,-C02Rea,-0S03H,- S03H, -S02H *-0P03H2 *-P03 (Rea) Printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs—P〇3H2, -p〇3 (H) c R ea), and -0P03CRee) 2, W1 is typically Ei Ei is typically ~ c 0 2 H,-C 0 2 R ea-— C02R4 or C02Ri, more typically C 02R4, where R14 is a positive or terminal secondary Cl — Ce alkyl group. It may also be a protected acid group, In this paper, it refers to the above-mentioned acidic groups and is protected by the groups commonly used in this technology, that is, the groups of Rea below. More typically, the protected Wi is a COaRa, S03Ri. ) A4 specification (210X297 mm) -36-426663 A7 B7 V. Description of the invention (34) -S (0) 〇Ri »-P (0) (0 R!) 2 * -C (0) NHS02R4, or- so2nhc (0)-R 4, where R i is Definitions. More typically, E 1 is selected from -C ((c H 2) c CH 3) 2 where bb + c = 1 to 4, or is selected from the following 0 p νΛ OH, 〇-CH3 «〇0 -ch3 / ch3 \ Q— »CH3 0V- < / Η, o ch3

CH, 〇 t o- ch3 O'wP V ^ S'OH, \\ / OH 〇 \\, 〇-CH3 V, 0H ′ ^ xo-ch3

Printed by the Consumer Cooperatives of the Central Government Bureau of the Ministry of Economic Affairs of the People's Republic of China.

-CN, -OH, 0Rea, -NOJ, where Ri and m 1 are as defined above.逋 is often-(C R lR 〇

W Stomach 2 is a group containing a basic heteroatom or a protected ammonium heteroatom, or a rebamine of the rotatable heteroatom. W2 usually contains basic heteroatoms, which in this context means non-carbon and can be acidic hydrogen (with the acid range of Gong 1 above) This paper size applies to China National Cricket (CNS) A4 specification (210X297 mm)

-37-A7 B7 / t 2 6 6 6 3 V. Description of the invention (35) (Please read the notes on the back before filling in page t) The atomic protection of printing and printing protection of Zhengong Consumer Cooperative, Central Standards Bureau, Ministry of Economic Affairs ** The basic principle is as described by Streitwieser and Heathcock (cited above), and gives the term "basic heteroatom j has the meaning understood by those skilled in the art. * Generally, the corresponding protonated form of the basic heteroatom used in the compounds in this case DK with the above Wi range. Basic heteroatoms include common heteroatoms in organic compounds, which have unshared, unbonded, η-type electron pairs, etc. By way of example and not limitation, typical basic heteroatoms include Oxygen, nitrogen and sulfur atoms of alcohols, amines, amidines, guanidines, sulfides, etc. Amidines are usually amines, amidines and guanidines. Usually bis 2 is amine or amine alkyl (usually lower alkyl), for example, amine Methyl, amine ethyl or amine propyl; formamyl or formamyl, such as formamyl methyl, methyl ethyl or formamyl; or guanidino or guanidyl, such as guanidyl methyl, guanidine Ethyl or guanidino (in each case, alkyl is used to bridge this basic group to Carbocyclic is more typically, W2 is amine, formamyl, guanidino, heterocyclic ring, heterocyclic ring substituted with 1 or 2 amine or guanidino (usually 1), or substituted with amine or guanidino C2-C3 alkyl, or C2-C3 alkyl substituted with an amine group and a second group selected from a hydroxyl group and an amine group. The heterocyclic ring that can be used as Gong 2 typically contains N or A 5- or 6-membered ring of S, which contains 1 or 2 heteroatoms. Such heterocycles are usually substituted by carbon atoms on the ring. It can be saturated or unsaturated and can be passed through a low alkyl group (m 1 = 1 or 2) or -NRi-is bonded to the core cyclohexene. More typically, W2 is an NHRi, -C (N Η) (Ν Η 2), -N R!-C (NR!) ( NR j R a) '-NH-C (Ν H) (Ν HR 3),-NH-C (Ν H) (Ν HR!)-This paper size is applicable to China Store Standard (CNS) A4 (21 OX297 mm) -38-426663 A7 B7 Printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs V. Invention Description (36) -NH-C (NH) NH2. -CH (CHaNHR!) (C Η 30 Η),- CH (CH2NHR!) (C Η 2N HR 1), -CH (NHR 1)-(CR! R 1) m2- CH (NHRi) Ri,-CH (〇H ) ~ (CH) m2- CH (NHR x) Ri, or one CH (NHR 1) one (CR! R i) CH (OH) R!-— (CR1R1) ra2-SC (NH) NH2, -N = C (NHR α) (R 3), -N = C (SRt) N (Rx) 2. -N (R j) C (NH) N (R!) C = N, or -N = C (NHU ( RJ; where each m2 is usually 0, usually, R3 is C (Ο) N (Rx) 2β can be any protected sloppy heteroatom, which refers to the basic atom mentioned above and is protected by groups commonly used in this technology such as Reb . Such groups are detailed in Greene (quoted above). Examples are, without limitation, amidine, carbamate, acetal, imine, enamine, N-alkyl or N-arylphosphine, N-alkyl or N-arylsulfinyl Or sulfofluorenyl, N-alkyl or N-arylsilyl, sulfide, thioester, disulfide, sulfinylsulfenyl, etc. In some specific examples, the Re b protecting group can be cleaved under physiological conditions. Typically, the case where it is cleaved in the body is, for example, the alkaline heteroatom and organic acid or amine group (such as natural Amino acid) or the peptides described in Rea below to form amidine. Typically, G i is selected from the following: The paper size applies the Chinese National Standard (CNS) A4 specification (2 丨 0X297 male feet) (Please read first (Notes on the back again »this page)

• 39-4 2 6 6 6 3 A7 B7 Five Description of the invention (37

V

NH 2 ^^ ΝΗ2

NH2 Y ^ NH

V ΗΙΝ

2 丫, Η Ν

YA NH NH2 Printed by the Consumer Cooperatives of the Central Bureau of Standards of the Ministry of Economic Affairs

Please read the notes on the back before filling

Alignment This paper size applies the Chinese National Standard (CNS) A4 specification (210X297 mm) -40-4266 6 3 > A7 B7 V. Description of the invention (38) _ Other series of examples are shown in Table 4. Ti is -NRiWa or a heterocyclic ring, or combined with 1; 1 or (; 1 to form a group of the formula:

V: I, where Re b is defined as follows, and rule 1 and message 1 are defined as above, the normal T is selected from the following:

w3 is W4 or Ws, where is 1 ^ or a C (0) R5, a C (◦) W5, _S02R5 or a S02Ws " W3 is typically -C (0) R 3 or W 3. R2 is printed by the Central Standards Bureau of the Ministry of Economic Affairs of the Shellfish Consumer Cooperative as R3 or R4 (as defined below), but each R 4 is replaced by 0 to 3 R 3; Ruler 3 is 卩, (: 1'81 ', 1, — € 1 ^, 1 ^ 3, —NOa > — ORea * — ORi '— N (R 1) 2 »—N (R j) (Ret.), — N (Ret >) 2, — SR j * This paper size applies to China National Standard (CNS) A4 specification (210X297 mm) ~ " 426663 A7 B7 Printed by the Consumers' Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs 5. Description of the invention (39 --- SR β a ^ — S (o) R 1 — S (0) 2 RX, — S (0) 0 R 1 T -S (〇) 0 R Θ &. > — S (0) 2 0 R! * -S (0) 2 0 R β a '— C (〇) 0 R 1, -C (〇) R 6 C 1 — C (0) 〇R Θ &. 9 -0 c (0) R 1 «— N (R! ) (c (0) R i) 1 — N (R Θ t >) (c (0) R 1) — N (R!) (c (0) 0 R!) 9 — N (R β t >) (c (〇) 0 R 1) »— C (0) N (R i) 2, — C (0) N (Re,) (R!)» — C (0) N (R β b) 2 t — c (NR!) (N (R 1) 2) 9 — C (N (R 6b)) (N (R 1) 2) »— C (N (R 1)) (N (R i) (R Θ b)) »— C (N (RB b)) (N (R 1) (R 6 fa)) >-C (N (R 1)) (N (Re b) 2) ♦ — C (N (R 6 b)) (N (R 6b) Ξ) — N (R,) C (N (R i)) (N (R x) 2) 9 — N (R 1) C (N (R i)) (N (R i) (R β b)), — N (R 1) C (N (R β b)) (N (R i) 2) — N (R Θ b) C (N (R 1)) CN (R i) a) y — N (R β b) c (N (R β b)) (N (RX) 2) t — N ( R Θ b) c CN (R a)) (N (R i) (R β b)) * ~ N (R 1) C (N (R 6 b)) (N (R!) (R β b) ) * Please refer to the note before reprinting. The paper size is applicable to China National Standard (CNS) A4 specification (210X 297 mm). Order -42-4 2 6 6 6 3 A7 B7 Employee Consumer Cooperatives, Central Standards Bureau, Ministry of Economic Affairs Printed 5. Description of the invention (40) -N (R!) C (N (RX)) (N (Reb) 2)--N (Reb) C (N (Reb)) (N (R x) ( Reb)) •-N ( R Gb) C (N (R x)) (N (Reb) 2), -N (R!) C (N (Reb)) (N (Reb) 2), -N (R 6b) C (N (Reb)) (N (Reb) 2), = 0, = S, = N (Ri) or (R0b) »R3 is typically F, Cl >-CN-N3 * N02--ORea *-ORj '- N (Rv) 2,-N (R!) (Reb),-N (Reb) 2 »-SR a > — SRea,-C (O) 0 R! *-C (O) Rec, -C ( 0) 0Rea, —0C (0) Ri, -NR! C (0) Ri, -N (R0b) C (0) R !, -C (0) N (R i) 2 >-C (0) N (R6b) (R!), —C (0) N (feet 613) 2 or = 0. More typically, only 3 with Reb include — (: (0) 1 ^ (feet 613) 2, -C (0) N (Reb) (R!), —C (S) N (Reb) 2 , Or a C (S) N (Reb) (R i). More typically, R3 is F, C 1,-CN, N 3 '-ORj--N (R!) 2 * —SRr-C (0 ) ORr-OC (0) Ri, or = 0. More typically, R3 is F, — ORi, — N (Rd 2 or = 0. In this case, represents an oxygen atom bonded by a double bond,, (Reb ) 'And, = N (Ri) * represents sulfur and nitrogen analogs. Rule 4 is (: 1-C12 alkyl, C2-C12 decyl or C2 c (Please read the precautions on the back before this page). Basically, the alkyl group has 1, 2 paper sizes. Applicable to the Chinese National Standard (CNS) Λ4 specification (210X 297 mm) —43 _ 4266 6 3 Β7 Printed by the Central Standards Bureau of the Ministry of Economic Affairs and the Consumers ’Cooperative V. Description of the invention (41)-. · -Y 9 »1 0 9 1 1 or 12 basic atom alkenyl and alkynyl have 2, 3 > 4» 5 9 6 7, 8 9 9 t 1 0- ] L 1 or 12 carbon atoms DR rat chalcedron (as defined above: 1 c When R 4; is alkenyl, usually vinyl (— C Η = C Η 2) 1 —propane — 1 —alkenyl (— C Η = c HCH 3) * 1 — — 2 — alkenyl (— C Η 2 CH = CH 2), 2 — propane 1 — alkenyl ( — C c = CH 2) (C Η 3)), 1 — but — 1 monoalkenyl (= C Η = CH c H 2 C Η 3), 1 — but — 2 — alkenyl (— C Η 2 CH = CH c Η 3), 1 —but—3 monoalkenyl C — C Η 2 CH 2 c H = C Η 2), 2 —methyl — 1 monopropyl — 1 — alkenyl (— c H = C ( C Η 3) 2) * 2 —methyl — 1 — prop — 2 — alkenyl (mono CH ϊ C (= C Η 2) (C Η 3)) ♦ 2 — butyl 1 — alkenyl (— C ( = c H 2) CH 2 C Η 3), 2 — butyl — 2 — alkyl (— C (CH 3) = CHCH a), 2 monobutyl — 3 — alkenyl (— C Η (CH 3) CH — CH 2) > 1 -pentyl 1 -alkenyl (-C = c HCH 2 c H 2 c H s), 1 -pentyl-2 -alkenyl (-C Η c H c HCH 3 CH a) 1-pentyl — 3 — thiol (— C Η c H 2 c HCHCH a) t 1 — pentyl — 4 — radix (— C c H 2C H 2 CH = CH 2) 9 2 —penta-1 alkenyl (— C (= CH 2) CH 2 CH 2 CH 3) > 2 —penta 2 — alkenyl (— C (CH 3 ) = CH 2 CH 2 CH 3) t 2 —pentyl — 3 —alkenyl (— c H (c H 3) CH = C Η C Η 3) 2 j — -pentyl--4--alkenyl (CH ( CH a) This paper size applies Chinese National Standard (CNS) A4 specification (210X 297 mm) -44-4- 2.6 6 6 ^ j a7 ________B7 V. Description of invention (42). Printed by the Consumers' Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs C C 2 * Η = C Η 2) or 3 -methyl- 1-but-2 monoalkenyl (mono-C Η 2 < Η: = C (CH a) 2) 0 Shiqu; more classic: type He • R 4 alkenyl has 2 »3 or 4 carbon atoms. When R 4 is alkynyl, it is typically ethynyl (-CC Η) t 1 —propanyl 1-decyl (-CCCH 3) -1 Η, -2- alkynyl (-C Η 2 C 1 C Η ), 1-butyl- -1--alkynyl (-CCC Η 2 1 C Η 3), 1-butyl-2-decanyl (-CH 2 CCC Η 3) 1-butyl- 3-fastyl (-CH 3C H 2 CC Η), 2 1-but 1- 3 alkynyl (C Η (C Η 3) CC Η), 1 -pentyl-1-alkynyl (-C cc H 2 CH a CH 3) 9 1-pentyl — 2 —alkynyl (-CH 2C CC: H 2 CH 3) 1 monopentyl — 3 monoalkynyl (mono H 2 CH 2 CCCH 3) or 1 —pentan 4-alkynyl (-CH 2 CH 2 CH 2 CCH t) ° More typically y R 4 alkynyl has 2, 3 or 4 carbon atoms. R 5 is R 4 (as defined above), or R 4 substituted with 0 to 3 R 3. Typically t R 5 Is C 1 -C 4 alkyl substituted by 0 to 3 fluorine atoms R 5 CL is C 1 ~ C 1: 2 alkylene, C 2-C 1 2 alkylene; or 0 to 3 R 3 substituted C 2 -C i 2 alkynyl. As defined in R 4 * R 5 G. is 1,2,3,4,5 -6 · 7, 8, 9, 1 0, 1 1 or 1 2 carbon atoms: alkylene; with 2 , 3, 4, 5, 6, 7 1 8 > 9, 1, 10, 1 1 or 1: 2 carbon atoms: typical R 4 groups for each alkynyl or alkynyl group, ie 1 is typical R 5 However, the open valency (open vali 3 π ce) of a carbon atom formed by removing a hydrogen atom in R ′ 1 is applicable to the Chinese paper standard (CNS) A4 (2 [〇 × 297mm) -45-Printed by the Consumer Cooperatives of the Central Bureau of Standards of the Ministry of Economic Affairs 426663 A7 ______B7___ 5. The description of the invention (43) is the second key of R. R10 is a Ci-Cu alkyl, alkenyl 'alkynyl group substituted by 0 to 3 of 112. R 1 1 is each Η or R 1 0. R12 is C3-C10 cycloalkyl, or C4-CIO cycloalkenyl. It is a positive or terminal secondary Cit-Ce alkyl group. w5 is a carbocyclic or heterocyclic ring, but each W5 is replaced by 0 to 3 feet 2 each. W5 carbocyclic ring and Ding 1 and Jian 5 heterocycle are stable chemical structures. These structures can be isolated from a reaction mixture at 78 ° C to 2o στ in measured yields, and have measurable purity β each double 5 each being replaced by 0 to 3 R2. Typically, 1'1 and double 5 are saturated with monocyclic or bicyclic carbocyclic or heterocyclic rings, unsaturated or aromatic rings. More typically, but 1 or 5 has 3 to 10 ring atoms, more Typically, 3 to 7 ring atoms, and usually 3 to 6 ring atoms. Ti and double 5 rings are saturated when they contain 3 ring atoms: saturated or monounsaturated when they contain 4 ring atoms; saturated, monounsaturated or diunsaturated when they contain 5 ring atoms When it contains 6 ring atoms, it is saturated, monounsaturated, diunsaturated, or aromatic. When only 5 are carbocyclic, it is typically a monocyclic ring of 3 to 7 carbons or 7 to 12 Carbon ring. More typically, a W5 monocyclic carbocyclic ring has 3 to 6 ring atoms, and more preferably 5 or 6 ring atoms. A bicyclic carbocyclic ring has 7 to 12 ring atoms and is arranged as a bicyclic [4,5], [5,5], or [6,6] system, more typically as a bicyclic [5,6] Or 9 or 10 ring atoms of the [6, 6] system. Examples include Cyclopropyl · This paper has a common Chinese National Standard (CNS) A4 size (2I0X297 mm) (Please read the precautions on the back before you need this page) -_ -46 426663, A7 _____B7__ V. Description of the invention ί 44) Cyclobutyl, cyclopentyl, cyclopentyl_1-alkenyl, 1-cyclopent-2-enyl, 1-cyclopentyl ~ 3-alkenyl, cyclohexyl, 1-cyclohexan-1 1-alkenyl * 1 One cyclohex-2-enyl, 1 one cyclohex-3—alkenyl, phenyl'spiryl and naphthyl. A Ti or ring is typically a single ring with 3 to 7 ring members (2 to 6 carbon atoms and 1 to 3 heteroatoms selected from N, 0, P, S), or 7 to 10 rings A bicyclic ring of members (4 to 9 carbon atoms and 1 to 3 heteroatoms selected from N, ◦, p, S). More typically, 1'1 and the bi-3 heterocyclic bicyclic ring have 3 to 6 ring atoms (2 to 5 carbon atoms and 1 to 2 heteroatoms selected from N, 0, S), and more typically 5 or 6 ring atoms (3 to 5 carbon atoms and 1 to 2 heteroatoms selected from N and S). 1'1 and boundary 5 heterocyclic bicyclic ring has 7 to 10 ring atoms (6 to 9 carbon atoms and 1 to 2 heteroatoms selected from N, 0, S), and it is arranged as a bicyclic ring [4 , 5], [5,5], [5,6] or [6 '6] systems, more typically 9 to 10 ring atoms (8 to 9 carbon atoms and 1 to 2 selected from N and Hetero atom of S), and it is arranged in a bicyclic [5,6] or [6,6] system. Printed by the Consumer Cooperatives of the Central Bureau of Standards of the Ministry of Economics. Typically, Tt and w5 heterocyclic systems are selected from: pyridyl, datrayl, pyrimidyl, pyridyl, S-triployl, oxazolyl 'imidazolyl' An oxazolyl, isoxazolyl, pyrazolyl, isoxazolyl, oxazolyl, furyl, thiofuranyl, warmphenyl or pyrrolyl. More typically, the 1'1 and bound 3 heterocyclic systems are bonded via their carbon or nitrogen atoms. More typically, the Tt heterocycle is bonded to the cyclohexene ring of the compound of the present invention by its nitrogen atom with a stable covalent bond. The w 5 heterocycle is based on its carbon or nitrogen. The original paper size applies the Chinese National Standard (CNS) A4 specification. (2Ϊ0-X297 mm) '" -47 — 426663 4 A7 B7 V. Description of the invention (45). The covalent bond is bonded to the cyclohexene ring of the compound of the present case. The stable covalent bond refers to the above chemical Stable structure. W 5 is arbitrarily selected from the following groups: 〇ν, 〇ν

Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs (VW:: ^^^ is the bond,-cr5r5—,-(CR5R5) 2—, 10-·-Ν (Η),-N (We)-, 1 N (OH)-, -N (OWe)---Ν (ΝΗ2), -Ν (Ν (Η) (W β))-,-Ν (Ν (We) 2)-,-Ν (Η) Ν (We) —, one S —, one SO —, or one S02 — typically; another 1 is a bond, —C R5R5 —, one (CR 5 R s) 2 — 'one 0 —, one N (H)-, —N (R 5) —, — Ν (0 Η) — * — Ν (0 R 5) —, —N (NH2) —, —N (N (H) (R5)) —, -N (Ν (R 5) 2)-,-Ν (Η) Ν (R 5)-, -S-, -SO-, or -S02, more typically ^^ is a bond, -CRiRi —, One (CR 1 R 1) 2 — * — 0 —, —, _ N (0 R 1) — '— N (NR 1 R 1) one — — S one, — S0-, or one S〇2 —. Usually 0 —, one NH —, one long paper is applicable to Chinese National Standard (CNS) A4 specifications (2 丨 OX ^ 97 mm) " One 48 _ 426663 A7 B7 V. Description of the invention (46). S —, One SO—, or one S 0 2 one; w6 is one R5,-Ws, One R5aW5, one C (0) OR6j Printed by the Consumer Cooperatives of the Central Bureau of Standards of the Ministry of Economy C (0) Rec, -C (0) N (R6b) 2 — C (NR 6b) (N (R eb) 2), one C (NR 6 b) c N (H), R β b)) * — C (Ν (H) (N (R β lb] 2) · — C (S) N: RB b) 2, or -C (〇) R Ξ is typically — R 5,--W 5 'or -R 5 aw s: In some tarffi systems, W β is R 1 9 -C (0) — R 1 '-CHR aW τ — C Η (R i) aw 7 J -CH (WT) 2-(where a is 0 or 1 but 0 when w T is bivalent) or -c (0) W τ. In some specific cases, -we is — C Η R iW 7 or —C (0) W 7, or W β is — (CH 2) ml c H ((c Ha) 1113R3) Ξ '— (C Η 3 ) ml C ((CH 2) m 3 R 3) 3 r one (C Η 3) ml c H ((CH 2) m 3 R 5 a W s) 2 * one (C Η 2) m 1 c H ( (CH 2) m 3 R 3) ((C Η 2) m 3 R 5 i .w 5) 1-(CH 2) ml C ((CH 2) m3 R 3 ^ 2 (c H 2) m 3 R 5 a. W a) (C Η 2) ml C ((C Η 2) m 3R 5aW 5) 3 or one (C Η 2) ml C ((CH 2) m 3 R 3) ((C Η 2) m 3 R 5aw 5) Ξ T where m 3 is an integer from 1 to 3. W 7 is R 3 or RS, but it is typically c 1 — C 12 substituted by 0 to 3 R 3. R 3 is typically selected from -NR! (R ab) 1 -NCR 6b) 2 1 — 0 R 3 Ά or S Rea »More typically W 7 -OR, this paper size applies Chinese National Standard (CNS) A4 specification (2IOX297 mm) Please read the note above

I

Page 17 -49-4 266 6 3 ν Λ Α7 __Β7_ V. Description of the invention (47) or C3-C12 alkyl substituted by OR :. Usually, 111 is 1110 —, — η〇 ^ -〇Λ Η〇 ^ ν ^ οΛ ηο / ^ '〇Λ' 〇Η OH-H3C, 〇a〇A h3c ^^ 〇 丫 * I '¥ ___ / 〇- : / · H3cA ^ 〇 丫 h3c 八 ^ 〇 丫, and, CH3, CH3 h3C ·

Ui is listed in Table 2 as an example. A specific example of the present invention includes a compound of the formula + · ul (

NIH

UJO N1H

Self-selected department type code but 1 E is 2 E

Ho < o o < o R6

S Ηoto

OHOH \ vOJ G is 2 G where

It is selected with 6a6a R R V 0 as the model, but 1¾ gauge 4 A 5 N C quasi-standard home country!

I Qinggong 7 9 2 X Ν Η 丨 Ν

Ν N. -50-426663 A7 B7 V. Description of the invention丫 ΝΗ2, / N γNH2 Η ch3. J t sch3 Η (ch3 H CH3 vnyn nh2 'NH2 ^ 9H3r " nh2

Ya N

• N > -nh2 nwS • N Λ, NH2

HN ah H htn, cn

Cfrt and

H

ry ", H where Ding 2 is a ruler 4 or 1 ^ 5. Usually T2 is a Cl-C2 radical substituted by 0 to 3 fluorine atoms. U 2 is one of the following: ---------- Shen Yi 丨 ----- ΐτ ------ ii (Please read the notes on the back first / ^ k 本 百;) Economy Printed by the Consumer Standards Cooperative of the Ministry of Standards, r7 '〇Λ r7 ^ V ^ 0 r7 Λ and .Λ where rule 7 is 11, one ch3, one ch2ch3, -ch2ch2ch3,-och3, -0 A c (— 0 — C (0) CH 3), -0H-—NH2 or —SH, typically H, —CH3 or —CH2CH3. This paper size applies the Chinese National Standard (CNS) A4 specification (210X297 mm) 426663: J A7 _B7__ V. Description of the invention (49) (Please read the precautions on the back before going to this page) R ea and Re eb are not important The functional group can be widely changed. When it is not tritium, its function is to act as an intermediate of the parent drug, but it is said that it is not biologically active. Conversely, the main function of these groups is to convert the parent drug into a prodrug, so that the prodrug is transformed in the body The mother drug was released. Because active prodrugs are easier to absorb than parent drugs, in fact • Prodrugs are more potent than parent drugs in the body. R 6a and Reb can be removed in vitro (in the case of chemical intermediates) or in vivo (in the case of prodrugs). When used as a chemical intermediate, it is not particularly important whether the resulting pro-functionality product *, for example, an alcohol, is physiologically acceptable, although it is usually preferred to be pharmaceutically innocuous. Is a hydrazone or an ether- or ester-forming group. "Ether-forming group" refers to a group S-0-va (v · ^, J-. -V ^ V ·) which can form a stable covalent bond between the parent molecule and the group shown below, Bu 0- Va (V3) S—〇-vb (v · ^, S—o-vb (v2), or S—o-VcM) Printed by the Central Ministry of Economic Affairs, the Zhenggong Consumer Cooperative, where va is a tetravalent atom, usually Selected from C and Si; vb is a trivalent atom, usually selected from B, AJ ?, N and P, more preferably N and P; VC is a divalent atom, usually selected from ο, s and Se, 'better is S; Vag is bonded to a group of Ve, Vb or Vc by a stable covalent single bond, preferably Vig W0, more preferably Η, R2, W5 or —Reads' is preferably Η or R2; Double bond is bonded to 7 8 or ^. Group, but 卩 2 is not applicable to Chinese paper standard (CNS) Λ4 specification (210X 297 mm) -52-A7 B7 V. Description of invention (50)舄 0 S or = N—, v2 is preferably = C (. Vd 2, where ^ 1 is as described above; V3 is a group bonded to Va with a stable covalent triple bond; preferably V 3 is three C (V i), where V 1 is as described above. "Forming group" refers to a group that can form a stable covalent bond between the parent molecule and the group shown below. S—0—VaO ^ KVJ S—0—Vb (V4) S—〇—Vd (V1) 2 (V4) *. 'T 5—-〇-Vd (V4) 2) 5— * 〇-Ve (V1 ) 3 (V4), or S ~~ 〇 ^ Ve (Vl) (V4) 2 where ve and Vi are as described above; vd is a pentavalent atom, preferably selected from P and N; is a hexavalent atom, preferably Is S; V4 is a group bonded to va, Vb, with a stable covalent double bond, but at least one V 4 is = 0, = S or = N — when it is not = 0, = S or = N , Preferably = c (Vi) 2, where Vi is as described above. A specific example of the -0H functional (whether hydroxyl, acid, or other functional) protecting group is a "ether-forming or ester-forming group". Among the groups forming the ether or ester forming group of the Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs, the ones that are particularly preferred are those that can be used as protective groups in the synthetic reaction diagrams herein. However, as will be understood by those skilled in the art, certain hydroxyl groups and thio-protecting groups are not ether-forming or ester-forming groups, and are included in the amines of Ree below. Rec can protect the hydroxyl or thio group, and the parent molecule is hydrolyzed to form a hydroxyl or thio group. As an ester-forming role * Typically, R 3 & is bonded to any acidic group (for example, as an example and not a limitation, -c 〇 2 Η or _ C (Private paper standard uses Chinese National Standard (CNS) Α4 specifications (210 × 297 mm) -53-4 266 6 3 B7 Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs 5. Description of the invention (51) 1] S) 0 ， and form _ C 0 Ξ R Θ a. For example , R β & can be deduced from W 1 1 I 0 9 5/07 9 2 0 in the polypolyacetic acid group disclosed 〇1 [R β G, examples include; 1 1 please IC 3 " -C 12 hetero Rings (as above) or aryls. These aryl groups can be polycyclic 1 1 rings or monocyclic rings. Examples are phenyl »Spiryl • 2-and 3-pyrrolyl t 2 back 1 | 1 — and 3 — _Phenyl, 2 — and 4 — imidazolyl, 2 —, 4 — ffrt and 5 — note! R thing 1 oxazolyl 9 3 — and 4 — isoxazolyl 2 —, 4 — and 5 — azole Base term% r Λ 1 1 3 -i 4 —and 5 -isomazolyl 3 -and 4 ——Pyrazolyl 1 —] Loading sheet 1 9 2 — y 3 —and 4 —pyridyl, 1 — 2 — 4 —and 5 monopyrimidyl S_f 1 i pyridyl 0 I! Substituted C 3 with the following groups Mono-Ci 2 heterocyclic or aryl halogen R 1 t I 1 R 1 ~ -0--Ci — C 1 2 alkylene, C 1 ~ C 1 2 alkoxy, CN, order 1 N 0 2 0 Η , Carboxycarboxylic esters * thiols, thioesters Cl — C 12 halo 1 I alkyl (1 to 6 halogen atoms), C 2 — C 1 2 alkenyl or C 2 — C 1 | 12 alkynyl ο such groups The group includes 2-, 3-alkoxyphenyl (C 1 1) (C 1 2 alkyl), 2-3-and 4-methoxyphenyl, 2-3-1 1 and 4-methoxyphenyl , 2 »3 —, 2, 4 — > 2, 5-> 2 > 1 i 6-3, 4 — with 3 1 5 -diethoxyphenyl» 2 — with 3 — ethoxy [1 carbonyl — 4-hydroxyphenyl, 2 — and 3- ethoxy — 4-hydroxyphenyl> 2 1 1 — »3 — and 4-0-ethynylphenyl, 2 — 3 — and 4 — methyl 1 1 Aminophenyl t 2-, Q Ο — 4 —methyl mercaptan phenyl »2 —, 3 — ~ and 4 1 I — halophenyl (including 2 —» 3-and 4 —phenyl with 2 — > 3 —I i I and 4 — chlorine Phenyl), 2 > 3 —, 2, 4 — 9 2, 5 — 2 1 1 6 — ♦ 3, 4 — and 3 1 5 — xylyl, 2 »3-, 2 4 1 1 paper size Applicable to China National Standard (CNS) A4 specification (21〇 × 297 mm) -54-4266 6 3 A7 B7 V. Description of the invention (52-, 2, 5 —, phenyl, 2, 3 — 2 2 1, 3 , 4—and 3,5-dicarboxyethyl 4.—, 2,5—, 2,6—, 3, 4 and 3,5-dimethoxyphenyl, 2 3 4-2 5-, 2 * 6 —, 3,4 mono and 3,5-dihalophenyl (including 2,4-difluorophenyl and 3 '5-diphenyl), 2- —, 3 — and 4-monohalobenzene (1 to 5 halogen atoms, Ca-Cu alkyl, including 4-trifluorotolyl), 2-, 3-, and 4-aminophenyl, 2-, 3-, and 4-nitrophenyl '2- '3 — and 4 monohalofluorene narrow groups (1 to 5 halogen atoms, Ci-C12 alkyl, including 4-trifluoromethyl and 2 —, 3 — and 4 a Chlorotolyl and 2-, 3- and 4-trichlorotolyl), 4-N-methylhexahydropyridyl, 3-N-methyl-hexahydropyridyl, 1-ethylhexahydropyridyl , Benzyl, alkyl salicylphenyl (Ci-'C4 alkyl, including 2-, 3- and 4-ethylsalylphenyl), 2-, 3- and 4-ethylethynylphenyl, 1 , 8-dihydroxyfluorenyl (—C10He — 0H) and aryloxyethyl [Ce-C9aryl (including phenoxyethyl)], 2, 2 " -dihydroxybiphenyl, 2-, 3-and 4 ~ N, N —dialkylamine phenol,-CeH4— CH2-N (CH3) 2 ------.--- pack-. 0 (Please read the precautions on the back before this page) Order economy Ministry of Standards and Technology Bureau employees' cooperatives print methoxy, triethoxy, 2-alkylpyridine (Ci-c4 ^ -based):

-CH2-0-C (0)

Rt0 (0) C

; 2-C4-Ce ester of carboxybenzene; and Ci-C4 alkylene ~ C-ca aryl group (including, benzyl, _CH2-pyrrolyl, one CH) This paper size applies to Chinese National Standard (CNS) Λ4 specifications (210X297 mm) -55-2 4266 6 3 A7 ___B7_ V. Description of the invention (53) _phenyl, -ch2-imidazolyl, one ch2 -oxazolyl, one ch2 -isoxazolyl, one ch2-_ An oxazolyl group, a ch2 —isoxazolyl group, — c h2 -pyrazolyl group, —c H2-pyridyl group and a C H2 —pyrimidyl group), and its aryl moiety is 3 to 5 halogen atoms or 1 to 2 atoms or groups selected from the group consisting of: halogen 'Ci-C12 alkoxy (including methoxy and ethoxy), cyano, nitro, 0H, (^ ― C12 haloalkyl (1 to 6 halogen atoms; including one CH2, CCJ? 3) > ct-<: 12 alkyl (including methyl and ethyl), (: 2-(: 12 alkenyl or <: 2-C 12 alkyne) Alkoxyethyl [Ci-ce alkyl, including a ch2_ch2_o -ch3 (methoxyethyl)]; an alkyl group substituted by the above-mentioned aryl substituent (especially 0H) or 1 to 3 halogen atoms (―CH3, one CH (CH3) 2, and --C (CH3) 3 * — CHgCHa *-(CH2) 2CH3, — (CH2) 3CH3, — (CH2) < iCH3, — (CH2) 5ch3 · ~ ch2ch2f. -C H 2 C H 2 C 1, one CH2CF3, and one ch2CC13)

Policy of Employees' Cooperatives of the Central Bureau of Standards of the Ministry of Economic Affairs: N-2 -propylmorpholinyl, 2,3 -dihydro-6 -hydroxy sesaminol, catechol monoester-CH2-C (0) (ri) 2, -CH 2- S (0) (R i), one CH2-s (0) z (R 1) '-CH 2- CH (0 C (0) CH 2R i) Ladder (CNS) A4 specification (210x297 ^ '-_ 56-A7 B7 V. Description of the invention (54) -ch2 (0C (Ο) ch2rm, cholesterol based, enol pyruvate (HOOC-C (= CH2) —), Glycerol: a mono-, di-, or oligosaccharide of 5 or 6 carbons (3 to 9 monosaccharide residues); a triglyceride, such as, is bonded thereto via a glycerol oxygen atom on the triglyceride Α-D-Θ-diglycerides of the parent molecular fluorenyl group (wherein the fatty acids constituting fatty glycerides are usually saturated or unsaturated (: β_2β, 06_18 or (: 6_1〇 fatty acids, such as linoleic acid, laurel Acids, myristic acid, palmitic acid, stearic acid, oleic acid, palmitic acid, linoleic acid and other fatty acids); phospholipids, which are bonded to carboxyl groups via phosphate esters on phosphoric acid; phthalo groups (C 1 ayt ο η etc. Person, A ntim icr 〇b. Agents C hem 0.5 (6): 6 70-67 1 [1 974] shown in the first figure); cyclic carbonate vinegar 'as (5-Rd_2 —fluorenyl 1 * 3— Dipyrocenone-4-yl) methyl ester (Sakamoto et al. (^ 116111.? 1131 · !!! · Bull. 32 (6) 2241-2248 [1984]), where Rd is Ri, R4 or aryl ; And please read the note on the back first, and then bind this page)) Printed by the Ministry of Economic Affairs of the Ministry of Economic Affairs, Standard Bureau, Consumer Cooperative—CH2C (0) N ^^ 〇r The disclosed groups are replaced by ffi, IV or V, or isoryl. In addition-for specific examples, Table A lists examples of the ester moiety of Rea 'which can be bonded via oxygen to, for example, a C (0) 0-and a P (〇) (〇_) 2 The basic paper size is applicable to the Chinese National Standard (CNS) M specification (210X297 mm) 4, 2 6 6 6 3 v A7 B7 5. The invention description (55) group. In addition, it is also listed Several recamine salts, which can be directly bonded to a C (0) —or—P (0) 2. The esters of structures 1 to 5, 8 to 10 and 16, 1 7, 19 to 2 2 are The compound with free hydroxyl group in this case and the corresponding halide (chloride or Chlorine, etc.) and N, N-dicyclohexyl-N-morpholinecarboxamidine (or other bases, such as DBU, triethylamine, C s C03, N, N-xylylamine, etc.) in DMF (or other solvents , Such as acetonitrile or N-methylpyrrolidone). When Wi is a phosphate, the structures 5 to 7, 11, 12, 21, and 23 to 26 are composed of alcohols or alkoxides (or corresponding amines, such as the examples of compounds 1 3, 1 4 and 15) and monochlorophosphoric acid Ester or dichlorophosphate (or another activated phosphate) by synthesis. Printed by the Central Standards Bureau of the Ministry of Economy, Industrial and Consumer Cooperatives 1. -CH2-C (0) -N (R1) 2 * 2. -CH2- S (〇) (Ri) 3.-CH2-S (0) 2 (Ri) 4 -CH2-0-C (0) -C% CeH5 5, Cholesteryl 6.3 -M pyridyl / — 7. Ν -Ethylmorpholinyl 8.-CH2-0-C (0) -C6H5 9.-CH2-〇-C (0) -CH2CH3 10.-CH2-0-C (0) -C (CH3) 3 11 -ch2-cci3 12. -C6H5 13. -NH-CH2-C (0) 0-CH2CH3 14. -N (CH3) -CH2-C (0) 0-CH2CH3 Ϊ5. -NHRi 16. -CH2-0 -C (0) -Ci〇Hi5 17.-CH2-0-C (0) -CH (CH3) 2 18.-CH2-C # H (0C (0) CH2Ri) -CH2-(OCiOJCHzRi) *

-CH, C (0) N 19. 20.

HO

21. HO

(Please read the notes on the back before filling this page}

Private paper size applies to China National Standard (CNS) A4 (2! 〇X 297 mm) 58-426663 A7 B7 V. Description of the invention (56 22, -CH2-0-C (0)

CH3CH90 (0) C 25.

twenty three.

OCH3 26. Other applicable esters in this case are described in EP. 632 048. R6a also contains functional groups that form "double esters".

Employees of the Bureau of Standards of the Ministry of Economic Affairs cooperated to print -CH2CX (0) OCH3, 〇-CH2SCOCH3, -CH2〇CON (CH3) 2 ^ or the following formula: CH (Ri or W5) 0 ((CO) R37) Or — (: 11 (111 or double 3) ((C0) 0R38) alkyl or aryl-oxyalkyl (which is an oxygen bonded to an acidic group), where R3T and R38 are alkyl, aromatic Group, or alkaryl group (see U.S. Patent No. 4,968,788). Generally, R 37 and R 38 are large groups, such as branched alkyl 'ortho-substituted aryl' meta-substituted aryl, or a combination thereof, including n, First-order and first-order Ci-ce radicals. Examples include tertiary pentamyloxymethyl, which is particularly useful in oral prodrugs. Examples of such useful Rea are alkoxymethyl esters and their derivatives, including -ch (ch2ch2och3) oc (o) c (ch3) 3,

〇 '-ch2oc (o) c10h15, -ch2oc (o) c (ch3) 3 / -CH (CH20CH3) 0C (0) C (CH3) 3, -CH (CH (CH3) 2) 〇C (0) C (CH3) 3, -CH20C (0) CH2CH (CH3) 2 / -CH2〇C (0) C6Hu, -CH20C (0) C6H5, -CH2〇C (0) Ci〇His -CH20C (0) CH2CH3,- CH20C (0) CH (CH3) 2, This paper standard uses the Chinese national standard i ·, -CH2〇C (0) C (CH3) 3 and CH2〇C (0) CH2C6H5 .---- (Please first (Read the notes on the back and fill in% this page)

-59-A7 B7 Printed by Shellfish Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs 5. Description of the Invention (57) When used as a prodrug, the selected esters are preferably those previously used in antibiotics, especially cyclic carbonic acid Ester, heavy ester 'or phthalate, aryl or alkyl ester. It should be noted that R ββ, R 6 £: and Reb can be arbitrarily used to prevent side reactions with protected groups in the synthesis step, so it can be used as a protecting group (PRT) in the synthesis »When deciding which group is to be protected As well as the nature of the PRT, it depends on the reaction chemistry to be protected (eg, acidic, basic, oxidizing, reducing, or other conditions) and the direction in which the synthesis is to be performed. If there are multiple PRT substitutions in the compound, the PRT group is not necessary and is usually not the same. In general, PRTs will be used to protect carboxyl, hydroxyl, or amine groups. The order of deprotection to obtain free radicals depends on the direction of the reaction and the reaction conditions, and can be determined by the skilled person. A large number of R hydroxyl protecting groups and R ec form amido groups and the chemical cutting reactions used are described in " 'Protective Groups in Organic Chemistry ^, Theodora W. Greene (John Wiley & Sons, Inc., New York , 1991, ISBN 0-471-8 2 3 0 1-6) (" * G reene '). See also K o c e n s k i, Ph i 1 i p J.; 'Protecting Groups * (Georg Thieme Verlag Stuttgart, New York, 1 9 94), which is incorporated herein by reference in its entirety. Special! ί is Chapter 1, Protecting Groups: An Overview, pages 1-20, Chapter 2, Hydroxyl Protecting Groups, pages 21-94, Chapter 3, Diol Protecting Groups, pages 95-117, Chapter 4, Carboxyl Protecting_ Factory scale is applicable to China National Standard (CNS) A4 specification (210X297 mmΐ ~ -60-{-(Please read the note on the back § and fill in 1 page) Line 2 6 6 6 3: A7 ____ * ____ B7 V. Description of the invention 丨 58〉

Groups, pages 118-154, Chapter 5, Carbonyl Protecting Groups, pages 1 55- 1 84. Wi acid protecting group: Rea carboxylic acid 'phosphonic acid, phosphonate, sulfonic acid and other protecting groups can refer to Greene below. Such groups include, by way of example and not limitation, esters, amidoamines, and the like. In some specific examples, the acid group is protected by Rea as an ester of the acid group, and R ^ is a hydroxyl-containing residue. In another specific example, Ree amine compounds are used to protect acid functional groups. Suitable hydroxyl- or amine-containing functional residues are as described above, or see WO 95/07920. In particular, it is a residue of an amino acid, an amino acid ester, a 'polypeptide or an aromatic alcohol. Typical amino acids, amino acid residues of peptides and carboxyl esterified amino acid residues are described in pages 1 1 to 18 of WO 9 5/0 7 9 2 0 and related texts, and are Li or L2 " W0 05 / 07920 teaches the formazan salts of phosphonic acids, but it should be understood that these formazan salts are formed with the acidic groups described herein or the amino acid residues shown in WO 9 5/0 7 9 2 0. The typical R ester printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs to protect the acidic functional groups of Wi is also described in W 0 9 5/0 7 9 2 0. Similarly, it should be understood that acidic groups can also be formed in this case. ; 9 2 0 Case phosphonate ester. Typical ester groups are at least as described in W 0 95/07920, pages 89-93 (under R31 or R 35, table on page 105, and pages 21-23 (R). Particularly preferred are esters of the following groups: Unsubstituted aryl, such as phenyl or aralkyl (such as fluorenyl), or aryl or alkaryl substituted with hydroxy, halogen, alkoxy, carboxyl and / or alkyl ester carboxyl, especially phenyl, O-Ethoxyphenyl, or Ci-C4 alkyl ester carboxyphenyl (Ci-Cl2 alkyl salicylate). Paper size applies to China National Standard (CNS) Λ4 specification (1 to 7 mm) ^ -61-4 2 6 6 6 3 4;, A7 A B7 Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs 5. Description of the invention (59) Protected acidic group Wi, especially when using esters or amines of WO 9 5/0 7 9 2 0 Can be used as an oral prodrug. However, the acidic group of Wi does not necessarily need to be protected before the compound of the present invention can be effectively used orally. When the compound of the present invention has a protective group (especially an amino formamidine salt or a substituted and When it is unsubstituted aryl ester), it is administered systemically or by alpha as long as it can be hydrolyzed and cut off in the body to give a free acid. Multiple acidic hydroxyl groups can be protected. If more than one hydroxyl group is protected, the same or different protecting groups can be used. For example, the esters can be the same or different, or mixed methyl salts and esters can be used. Typical R hydroxyl protecting groups are described in Green (pages 1 4-1 18) includes ethers (methyl): substituted methyl ethers (methoxymethyl, methylthiomethyl, tertiary butylthiomethyl, (benzenedisilyl) Methoxymethyl, benzyloxymethyl, p-methoxyphenoxymethyl, (4-methoxyphenoxy) methyl, o-methoxyphenol methyl, tertiary butoxymethyl, 4-pentenyloxymethyl Methyl, siloxymethyl, 2-methoxyethoxymethyl, 2,2,2-trichloroethoxymethyl, bis (2-chloroethoxy) methyl, 2- (trimethylsilyl) ethoxy Methyl, tetrahydropiperanyl, 3-bromotetrahydropiperanyl, tetrahydrothiopiperanyl, 1-methoxycyclohexyl, 4 monomethoxytetrahydropiperanyl, 4 monomethoxytetrahydrosulfanyl Piperanyl, 4-methoxytetrahydrothiopiperanyl, s, S-dioxy (dioxido) '1-[(2-chloro-4-methyl) phenyl] -4-methoxy-6 Hydropyridine-4-yl, 35,1,4-dioxane-2 Group, tetrahydrofuranyl 'tetrahydrothiofuranyl, 2,3,3a, 4,5,6,7,7 octahydro-7,8,8-trimethyl-4,7-methylbenzobenzofuran- 2-based)]: substituted ether (1-ethoxyethyl, 1- (This paper size applies to Chinese national standards (CNS> Λ4 specifications (210X297 gong) -62 — 266 6 3 Α7 Β7 V. Description of the invention (6〇2-chloroethoxy) ethyl, 1-methyl-1 methoxy-ethyl, i-methyl-1 1-carboxyethyl, 1-methyl. 1-yloxy-1- Fluoroethyl, 2 '2,2-trichloroethyl, 2-trimethylsilylethyl, 2- (phenylselenyl) ethyl, tertiary butyl, allyl, p-chlorophenyl, p-methoxy Phenyl, 2,4-dinitrophenyl, benzyl; substituted benzyl ethers (p-methoxyfluorenyl, 3,4-dimethoxybenzyl, o-nitrofluorenyl, p-nitrobenzyl , P-halobenzyl '2,6-dichlorobenzyl, p-cyanobenzyl, p-benzene narrower, 2 one and 4 one pyridylmethyl, 3-methyl one 2-pyridylmethyl N-oxide, two Benzyl, P, -dinitrodiphenylmethyl, 5-dibenzocycloheptyl, triphenyl Methyl, α-A phenyldiphenylmethyl, p-methoxyphenyldiphenylmethyl • bis (p-methoxyphenyl) benzyl, tris (p-methoxyphenyl) methyl, 4, 4 > , 4 mono (4 > monobromophenylfluorenyloxy) phenyldiphenylmethyl, 4, tris (4,5-dichlorophthalimidophenyliminophenyl) methyl 4yl, 4 4-, 4 * tri (笮 醯 phenyl) methyl, 3- (imidazol-1-ylmethyl) bis (4tris (ethylpyridinyloxyphenyl) methyl, 4 Central Standards of the Ministry of Economic Affairs, Employee Consumption Cooperative Printed Oxygen 4 >, 4 '-diphenyl) -1 > monofluorenyl, 9-(9 di-alkane-2-yl ether (trimethylsilylsilyl, diethylisosilyl, tertiary butylsilyl) > triphenylsilyl Phenylsilyl): ester methoxyphenyl) methyl, 1,1-bis (4-methoxyfluorenylmethyl, 9-M group, 9-Phenyl-10 keto) M group, benzoiso _Azolyl S, S —di, triethylsilyl, triisopropylsilylpropylsilyl, dimethylhexylsilyl, diphenylsilyl, tribenzylsilyl, diphenylsilyl, Formate, benzamidine formate, (9-phenyl) 1,3oxy), Tertiary butyl * tri-p-tributylacetate_benzo: silylmethylpropyldimethyl dimethyl dimethyl.oxy, chloroethyl paper Standards applicable to Chinese National Standard (CNS) A4 (210x297 male thin) -63-4 .266 6 3 A7 B7 V. Description of the invention (61 Ester | Dichloroacetate * trichloroacetate, trifluoroacetate, methoxyacetate, triphenylmethoxyacetate Esters • phenoxyacetate, p-chlorophenoxyacetate, p-polyphenylacetate, 3-phenylpropionate ketovalerate 4-(ethylene dithio) valerate, tertiary valerate Ester, adamantanoate, crotonate, 4-methoxycrotonate, benzoate, p-phenylbenzoate, 2,4,6-trimethylbenzoate (mesitoate); carbonic acid Esters (methyl, 9-alanylmethyl, ethyl, 2,2,2-trichloroethyl, 2- (trimethylsilyl) ethyl, 2- (benzenesulfonyl) ethyl, 2- ( Triphenylphosphinofluorenyl) ethyl, isobutyl, vinyl, allyl, p-nitrophenyl, benzyl, p-methoxybenzyl, 3,4-dimethoxybenzyl, o-nitrobenzyl, P-nitrofluorenyl, S-fluorenylthiocarbonate, 4-ethoxy-1- Methyl dithiocarbonate); a group with a cleavage assisting group (2-iodobenzoate, 4-azidobutyrate, 4-nitro-4-, o- (dibromomethyl) benzoate Acid ester, 2-methylmethylbenzoic acid 2- (methylthiomethoxy) ethyl ester, 4-mono (methylthiomethoxymethylvalerate sulfonate, carbon-based) butyrate Printed by Industrial and Consumer Cooperatives, 2- (methylthiomethoxymethyl) benzoate); other esters (2,6-dichloro-4 monomethylphenoxyacetate, 2,6-dichloro-4 — (1,1,1,3,3-tetramethylbutyl) phenoxyacetate, 2,4-bis (1,1-dimethylpropyl) phenoxyacetate | monosuccinate Chlorodiphenylacetate, isobutyl (E)-2 -methyl 1-2 -butenoate (tigloate), o- (methoxycarbonyl) benzene, α-some ester, nitrate, alkyl, N methylphosphine methyl fat salt, N-phenylcarbamate *, 2,4-dinitrophenyl sulfenate); formate, para-benzoate-N · N ^ borate, Second, as well as sulfonic acid esters, N / -tetramethylphosphinosulfanyl (sulfate esters, private paper standards applicable in National Interpolation Standard (CNS) Λ4 specification (2 丨 0X297 mm) -64 ^ 4 266 6 3; A7 _ body _B7 ___ V. Description of the invention (62) Mesylate, benzylsulfonate | p-toluenesulfonic acid Esters) > More typically, Rea hydroxyl protecting groups include substituted methyl ethers, substituted benzyl ethers, silyl ethers, and esters including sulfonates, preferably trialkylsilyl ethers, p-toluenesulfonates With acetate. Typical 1,2-diol protecting groups (so, usually, the two 0H groups are combined with the protecting group) as described in Greene, pages 1 1-8-1 42, including cyclic acetals and ketals (methylene, Ethylene, 1-tert-butylethylene, 1-phenylethylene * (4-methoxyphenyl) ethylene, 2,

2,2-trichloroethylene, acetone (isopropylidene), cyclopentylene, cyclohexylene, cycloheptylene * benzylidene, p-methoxybenzylidene, 2,4-dimethylene Oxymethylene, 3,4 dimethoxymethylene, 2-nitromethylene: cyclic ortho esters (methoxymethylene, ethoxymethylene, dimethyloxymethylene Methyl, 1-methoxymethylene, 1-ethoxyethylene, 1, 2-methoxyethylene, α-methoxyethylene, 1- (N, N Printed by Consumer Cooperatives (please read the notes on the back before filling in the special page) — dimethylamino) ethylene derivative, α — (N, N — dimethylamino) benzylidene derivative, 2 _ Oxacyclopentylidene); silyl derivatives (di-third butylsilylene, 1,3- (1,1,3,3-tetraisopropyldisilylidene), and Four third butoxydisilaxane-1, 3-diidene), cyclic carbonate, cyclic borate, ethyl borate and phenyl borate. More typically, the 1,2-diol protecting groups include those shown in Table B. • More preferably, epoxides, acetones, • cyclic ketals and aryl acetals. This paper size applies Chinese National Standard (CNS) A4 specification (210 × 297 mm) 4 266 6 ^ at ----- " " _ B7 V. Description of the Invention i: 63) B Table Λ V- ο

X γο τον Ο ΠΟ Fτα. R9 V-, ΝΟ I ο 9 RWTO Ν b R9 ο ο το, 々ο V- 0: 0

Printed by the Consumer Cooperatives of the Central Bureau of Standards of the Ministry of Economic Affairs

Among them, 9-foot is a 0-ce alkyl group. Reb is the residue of amidine, amino protecting group or carboxyl-containing compound, especially amidine, a C (0) R4, amino acid, polypeptide, or not a C (〇) R4 'amino acid' polypeptide base. Examples of R forming amidine are shown in G. When Reb is an amino acid or polypeptide, its structure is R13NHCH (Rie) c (0) ~, where r15 is fluorene, amino acid or polymorphic residues, or R3, and Rie is defined as follows: β R 1β is a low alkane Or ci-C β lower alkyl substituted with: amino, carboxyl, amido, carboxylate, hydroxyl, ce-c7 aryl, guanidyl, imidazolyl, indyl, fluorenyl, amidine And / or alkyl phosphonates. R1. It can also be combined with α-N of amino acids to form proline residues (1 ^. = — (CH2) 3-). However, R10 is usually a side chain of a natural amino acid, such as Η, -C Η 3, -CH (C Η 3) 2, -C Η 2-CH (CH3) 2 >-CHCH3-CH2-CH3 * — CH2— CeH5, — CH2CH2 — S — CH3, —CH 2 0 H, — CH (〇H) — CH3, —CH2-SH This paper is sized to the Chinese National Standard (CNS) A4 specifications < X297 mm> < Read first Read the notes on the reverse side and fill in this page)-, tT- 4 266 6 3 ^ V. Description of the invention (64> > _CH2-CeH4OH »-CHz-C〇-NH2- -ch2-ch2-co-nh2 · -ch2-co〇h -ch2-ch2-cooh,-(CHZ) 4-NH2 and-(CH2) 3-NH- c (nh2)-nh2. R " also includes 1-guanidino-3-yl, benzyl Group, 4-hydroxymethyl group, imidino- 4-yl group, indyl group 3-methyl 'methoxyphenyl and ethoxyphenyl group. In most cases, Reb is a carboxylic acid residue' but any Greene's typical amine protecting groups as described on pages 3 1 5-3 8 5. Including carbamate (methyl, ethyl '9-bismethyl' 9 (2-sulfonyl) thin methyl, 9 1 (2 '7-dibromo) Pyridyl, 2' 7-di-tert-butyl- [9- (10,10-diketo-10,10, 10-tetrahydrothioxanthryl)]] methyl, 4-monomethoxybenzylmethyl); substituted ethyl (2,2,2-trichloroethyl, 2-trimethylsilylethyl, 2-phenethyl, 1- (1-adamantyl) -1, 1-methylethyl, 1, 1-dimethyl-2, 2-haloethyl, 1, 1-dimethyl-2, 2-dibromoethyl 1,1,1-dimethyl-2,2,2,2-trichloroethane Printed by the Consumer Cooperative of the Central Bureau of Standards, Ministry of Economic Affairs, 1-methyl-1, (4-biphenyl) ethyl, 1- (3,5 bis-third butylphenyl) -1-methylethyl, 2- (2 > and 4 * -pyridyl) ethyl, 2- (N, N-dicyclohexylcarboxamido) Ethyl, third butyl, 1-adamantyl, vinyl, allyl, 1-isopropylallyl, cinnamyl, 4-nitrocinnyl, 8-darkolinyl, N-hydroxyhexa Hydropyridyl, Alkyldithio, Ethyl-p-methoxybenzyl, p-nitrofluorenyl, p-bromobenzyl, p-chlorofluorenyl, 2,4-dichlorofluorenyl, 4-methylsulfinylfluorenyl Benzyl, 9-M-methyl, benzhydryl): with help to break this paper scale applicable national or national standard (CNS) Λ4 specification (210X297 revolutions) 67 4266 6 3 A7 B7_ V. Description of the invention (65) The group (2-methylthioethyl, 2-methylsulfonylethyl, 2- (p-toluenesulfonyl) ) Ethyl, [2- (1,3-Diazapentane)] methyl, 4-methylthiophenyl, 2,4-dimethylthiophenyl, 2-phosphoniumethyl, 2-triphenylphosphine醯 Isopropyl, 1,1-dimethyl-2-cyanoethyl, m-chloro-p-oxofluorenyl, p- (dihydroxyboryl) benzyl, 5-benzobenzoisoprazolemethyl, 2- (Trifluoromethyl) -6-chromemethyl); photolysable groups (m-nitrophenyl, 3,5-dimethoxybenzyl, o-nitrobenzyl, 3,4-dimethoxy-6- Nitrosyl, phenyl (o-nitrophenyl) methyl); urea derivatives (benzene_trapyl (1 0) —carbonyl, N > —p-toluenesulfonylamine carbonyl, N > —aniline sulfur Carbonyl); other carbamates (third pentyl, 5-benzyl thiocarbamate, p-cyanobenzyl, cyclobutane, cyclohexyl, cyclopentyl, cyclopropylmethyl, p-decyloxy Benzyl, diisopropylmethyl, 2,2-dimethoxycarbonylvinyl, o- (N, N-dimethylcarboxylate Amine) benzyl, 1,1, dimethyl-1,3- (N, N-dimethylcarboxamide) propyl, 1 printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs, 1-dimethylpropenyl (2-pyridyl) methyl, 2-furanmethyl · 2-iodoethyl, isobornenyl, isobutyl, isonicotinofluorenyl, p- (p-methoxyphenylazo) benzyl Methyl, 1-methylcyclobutyl, 1-methylcyclohexyl, 1-methyl-1 -cyclopropylmethyl, 1-methyl-1-(3,5-dimethoxyphenyl) ethyl , 1-methyl-1— (p-phenylazophenyl) ethyl, 1—methyl-1—phenethyl, 1—methyl-1— (4-pyridinyl) ethyl, phenyl, P- (Benzazolyl) fluorenyl, 2,4,6-tritributylphenyl, 4-mono (trimethylammonium) fluorenyl, 2,4,6-triethylfluorenyl): fluorenamine (N -Formamyl, N-ethenyl

, N —chloroethenyl, N —trichloroethenyl, N —trifluoroethenyl, N t scale applicable to Chinese national standard _ (__ CNS) A4 specification (210X 297 mm) -68-4 266 6 3 i at _ B7____ V. Description of the invention (66). Monophenylethyl, N-3-phenylphenyl, N-picolinyl, N-3-pyridylcarboxamide 'N-Benzamidine Benzamidine, N-benzyl, N-p-phenylbenzyl): ammonium (N-o-n-phenethylethyl, o-nitrophenethyl) , N-acetaldehyde acetamidino, (N,-dithiobenzyloxycarbonylamino) acetate, N ~ 3- (p-hydroxyphenyl) propanyl, N 3-(o-nitrophenyl) propanyl 2-methyl-N-2-methyl- 2- (4-chlorochloromethyl), 4-methyl-2- (o-nitrophenoxy) propanyl-o-phenylazophenylphenoxy), 醯 economy The Ministry of Central Standards Bureau ’s work-consumer cooperation has printed 1-methyl-1, 3-nitrobutyridinyl, Ν-o-nitrocinylpyridinyl, Ν-ethylenylmethionine, Ν-o-nitrobenzyl, Ν-o-one (Benzylideneoxy) benzylidene, 4,5-diphenyl-3oxazoline 2 monoketone): Cyclopentimine derivatives (N-phthalimide, N-diazasuccinyl, N-2,3-diphenylcis-butenylfluorenyl, dimethylpyrrolyl, Ν — 1 * 1,4,4 —Tetramethyldiazacycline adduct, 5 —Substituted 1,3-dimethyl-1,3,5, —triazacyclohexane One 2-keto, 5-substituted 1, 3-difluorenyl-1, 3, 5-triazacyclohexane-2, one ketone, 1 once substituted 3, 5-dinitro-4-pyridinone ); N-alkyl and N-arylamine (N-methyl 'N-allyl, N-C 2-(trimethylsilyl) ethoxy] methyl' N-3 -ethoxypropane N, (1 -isopropyl-4, 4-nitro, 2-keto, 3-, 3-pyrroline-3, -yl) 'quaternary ammonium salt' Ν -fluorenyl 'Ν -di (4-methyl Oxyphenyl) methyl 'Ν_5-dibenzocycloheptyl, Ν-trityl, Ν- (4-methoxyphenyl) diphenylmethyl' Ν-9-benzyl, Ν-2 7 —Dichloro—9 —fluoromethylene 'Ν_ Dimocene This paper standard is applicable to China National Standard (CNS) A4 Specification (2 丨 〇 Χ297mm) -69-Printed by the Consumer Cooperative of the Central Bureau of Standards, Ministry of Economic Affairs, 4266 6 3 ^; at Β7 V. Description of the Invention (67) Ferromethyl, N-2-Picolinolin N < — Oxides), imine derivatives (N-1, 1-dimethylthiomethylene, N-benzylidene, N-p-methoxymethylene, N-diphenylmethylene, N-[(2 -Pyridyl) a certain group] methylene, N (N >, N > -dimethylamine) methylene, N, N-isopropylidene, N-p-nitrosylidene, N-saluclidene , N — 5 _ chlorosalylene, N — (5-chloro-2-hydroxyphenyl) benzylidene, N — cyclohexylene); enamine derivatives (N — (5, 5 — dimethyl -3-keto-1-cyclohexenyl)); N-metal derivatives (N-borane derivatives, N-diphenylboronic acid derivatives, N-[phenyl (chromium pentacarbonyl or tungsten)] carbon Alkenyl * N-copper or N-zinc admixture); N-N derivatives (N-nitro, N-nitroso, N-oxide); N-P derivatives (N-diphenylphosphine) Group, N-dimethylsulfanyl group, N-diphenylsulfanyl group, N-dialkylphosphonium group, N-dimethylphosphonium group, diphenyl group N-Si derivative; N-S derivative: N-sulfinyl sulfenyl derivative (N-benzenesulfinyl fluorenyl, N-o-nitrophenylsulfinyl sulfinyl, N-2, 4 —Dinitrobenzenesulfenyl sulfenyl, N-pentachlorobenzenesulfenyl sulfenyl, N-2 —nitro-4 —methoxybenzosulfinyl sulfenyl, N —triphenylmethyl sulfenyl sulfenyl, N — 3 _ Nitropyridine sulfinyl): and N-sulfofluorenyl derivatives (N_p-toluenesulfonyl, N-2,3,6-trimethyl-4 monomethoxybenzenesulfonyl, N-2 , 4,6-trimethoxybenzenesulfonyl, N-2,6-dimethyl-4 monomethoxybenzenesulfonyl, N-pentamethylbenzenesulfonyl, N_2,3,5,6-tetramethyl Methyl—4-methoxybenzenesulfonyl, N—4-methoxybenzenesulfonyl, N—2, 4,6-trimethylsulfonylsulfonyl, N—2, 6—dimethoxy-4— Tosylsulfonyl, N-2,2,5,7,8 — This paper size applies to China National Standard (CNS) Λ4 specification (2_! 0 '乂 297mm)' ~ '-70-(Please read first (Notes on the back again # -like this page)

A7 B7 Printed by the Consumer Cooperatives of the Central Bureau of Standards of the Ministry of Economic Affairs 426663 V. Description of the Invention (68) Wujia spray-6—Expansion base 1 N —Formyl acid base N — —Thionyl sulfonyl group, NMS -9 — M fluorenyl, N_4-(4 ^ '8-dimethoxymethyl) benzenesulfonyl, N_fluorenylsulfonyl, N —trifluoromethanesulfonyl, N—phenylethylfluoren Sulfo)). More typically, the protected amine group includes carbamate and amidine, more preferably —NHC (0) Ri or —N = CRiN (Ri) 2. Another protective group can also be used as the antecedent 'at the Gi position. Especially for amine groups or -N H (R 5) is:

References, for example, Alexander, J. et al .; Group, —nhso2r4, nhc (0) r4, -N (R4) 2, NH2 or —NH (R4) hydrazone, whereby the carboxyl group or phosphonic acid group of Wi reacts with the above amine group to form amines such as -C ( 0) Re. — — P (O) (Ruler 0.) 2 or -P (Ο) (OH) (Rec). Generally Rec has the structure of R17C (0) CH (Rie) NH-, where R17 is 0H, 0Ree, 0R5, amino acid or polypeptide residue. "Amino acid is a low molecular weight compound, less than about 100 MW, and Contains at least one amine or imine group, and at least one carboxyl group. Generally, this amino acid exists in nature, that is, it can be applied to biological substances (such as bacteria or its paper size to apply Chinese National Standard (CNS) A4 specifications (210X297 mm)) (please read the precautions on the back before filling in ¾) (.. this page)

-71-A7 B7 4 266 6 3 ^ 5. Description of the invention (eg) detected in other microorganisms, plants, animals or humans. A suitable amino acid is typically α-amino acid, i.e. one amine or imino nitrogen atom in the compound is separated from a carbon atom of a carboxyl group by a mono- or unsubstituted α-carbon atom. Preferred are hydrophobic residues, such as mono- or di-alkyl or arylamino acids, cycloalkylamino acids and the like. These residues contribute to cell permeability by increasing the distribution coefficient of the parent drug. Typically, this residue does not contain a fluorenyl or guanidyl substituent. Natural amino acid residues are residues found naturally in plants, animals or microorganisms, especially their proteins. * Polypeptides are typically composed of such natural amino acid residues. "These amino acids are glycine , Alanine, valine, leucine, isoleucine, serine, threonine, cysteine, methionine, glutamine, aspartic acid, lysine, hydroxylysine Glycine, arginine, histamine, phenylalanine, tyrosine, leucine, proline, asparagine, glutamine and hydroxyproline. Printed by the Consumer Cooperatives of the Central Bureau of Standards of the Ministry of Economic Affairs. When Re b and Rec are monoamino acid residues or peptides, they are usually substituted with We, Wi and / or 诹 2, but it is better only for double 1 or double 2 There are replacements. These conjugates are formed by forming an amidine chain between the carboxyl group of the amino acid (or, for example, the carbon-terminal amino acid of a peptide) and selenium 2. Similarly, conjugates can also be formed between Wi and amino groups or peptide amino groups. Generally, only one position in the parent drug is amidated with an amino acid as described herein, but introduced at more than one position Amino acids are also within the scope of the invention. Generally, the carboxyl group of Wi is aminated with an amino acid. Usually, the α-amino group or α-carboxyl group of the amino acid or the terminal amine group or carboxyl group of the polypeptide is connected to the functional group of the parent compound; that is, the carboxyl group or amine group on the amino acid branch chain is not used to form the heart ^ Standards General Chinese National Standard 1 Shangyang) People 4 Specifications (2 丨 0 Father 297 mm) '' -72-Shelling Consumer Cooperatives, Central Standards Bureau of the Ministry of Economic Affairs 4266 6 3 Λ a? __Β7 _____ V. Description of the Invention (7 〇) Amido linkages with the parent compound (although these groups may need to be protected during conjugate tree synthesis, as described below). Regarding the carboxyl group-containing side chain of an amino acid or a polypeptide, it is understood that the carboxyl group can be protected arbitrarily, for example, 'esterified with R' or with R 5 or aminated with R sc 醯. Similarly, the amino acid branched Ri 6 can be optionally protected by R or substituted with R 5. These esters or amido linkages formed with side chain amine or carboxyl groups, like the ester or amido linkages formed with the parent molecule, may be either acidic (pH < 3) or basic (pH >) in vivo or in vitro; L 0). In addition * it can be stable in the human gastrointestinal tract, but can be hydrolyzed by enzymes in the blood or cells. These esters or amino acids or polypeptide amides can also be used as intermediates in the preparation of the free amine- or carboxyl-containing parent compound. The free acid or base of the parent compound can be easily prepared from the ester or amino acid or polypeptide conjugate of the present invention by hydrolysis. When the amino acid residue contains one or more palmar centers, any D, L, meso, threo or erytho (as appropriate) racemic mixture can be used, the crystalline isomer ( scalemates) or mixtures thereof. Generally, if the intermediate is intended to be non-enzymatically hydrolyzed (for example, this amide is used as a chemical intermediate for free acids or free amines), the D isomer is useful. On the other hand, the L isomer is more useful because it can be hydrolyzed enzymatically or non-enzymatically and can be more efficiently delivered by amino acids or dipeptide delivery systems in the gastrointestinal tract. Examples of suitable acid amines (the residues are listed in Reb and Rec) include the following: This paper size applies the Chinese National Standard (CNS) Λ4 specification (210X297 mm) (please read the note on the back before ^ this Page) • Pack.-Order 73 A7 B7 4 2 6663;-V. Description of the invention (71) Glycine; (Please read the precautions on the back before filling this page) Amino polycarboxylic acid, for example, Asparagus Glycine 'β -Hydroxyaspartic acid' glutamic acid, stone monohydroxyglutamic acid, in case of methyl aspartic acid '/ 9 monomethyl glutamic acid, spot, dimethyl aspartic acid Acid, 7-hydroxyglutamic acid, jS, r-dihydroxyglutamic acid, phenylglutamic acid 'r-methyleneglutamic acid' 3-aminoadipate, 2-aminopimelate '2 _Amino suberic acid and 2-aminosebacic acid: Aminocarboxamides, such as glutamine and asparagine: Polyamino- or polyvalent monocarboxylic acids 'as arginine' lysine Acid 'Θ monoaminoalanine, r monoaminobutyric acid' guanine acid 'citrulline' high spermic acid, homocitrulline, hydroxylysine 'allelysine and diaminobutyric acid Acid: Other basic amino acid residues such as histidine -Feed, · diaminodicarboxylic acids, such as, α, α diaminosuccinic acid, α, α-diaminoglutamic acid, α, α ζ —diaminoadipic acid, 0 :, α, monodiaminopimelate 'α, α / -diaminomonomelimelic acid, α, α --diaminosuberic acid, α, α --diamine azelaic acid, And α., Α ^ · —Diamino sebacic acid: imine acids printed by the Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs, such as proline, hydroxyproline, and doxamine * r_ methylproline Amino acid, piperidine 2-carboxylic acid, 5-hydroxypiperidine 2-carboxylic acid, and aziridine 2-carboxylic acid; mono- or dialkyl (preferably Cl-C 8 branched or linear) Amino acids such as alanine, valine, leucine, allylglycine 'butine, n-valine, n-leucine, heptamine * α-methylserine, α — Amino-α-methyl-T-hydroxyvaleric acid, α-Amino-α-methyl-1, Zhang scale applicable to China National Standard (CNS) M specifications (210X 297 mm) '~ -74-4 2 6 6 6 3 v a7 B7 Consumer Cooperatives, Central Bureau of Standards, Ministry of Economic Affairs Preparation of the invention (72). 1 I δ-hydroxyvaleric acid 1 a —amino — a — methyl — e-hydroxy • SXS hexanoic acid iso. 1 1 1 valine, a monomethyl glutamic acid 9 a Monoaminoisobutyric acid * a Monoamine 1 1] Diethylacetic acid 1 a —Amino diisopropylacetate Sa — Amino — di-n-propyl Please 1! Acetic acid, a — Amine — Diisobutylacetic acid ja monoamino — di-n-butyl first 1 1 acetic acid, a — aminoethylisopropylacetic acid ♦ a monoamine ____ n-propylacetic acid on the back 1 I of 1 a — amine Diisopentylacetic acid 9 a — methyl aspartic acid a — methyl Note! I glutamic acid, 1 monoaminocyclopropane — 1 — carboxylic acid 9 isoleucine * iL -1 、 | Amino acid, tertiary leucine 9 β —methylleucine I and a __ amino group-β —,]] Sheet 1 ethyl-0-phenylpropionic acid t 1 I β " • benzene Silk Fluorenyl 1 1 1 aliphatic α —amino-β — hydroxy acid »such as serine β — hydroxy 1 1 order 1 leucine > β hydroxy ortholeucine β — hydroxy orthovaline» and a — Amino-β-hydroxystearic acid 1 1 a -Amino-a-hydrazone — δ — or ε — hydroxy acids such as »high 1 1 serine, r — hydroxyorthovaline δ monohydroxyorvaline e _ i) Linear hydroxyl ortholeucine residues 1 cananosine and cana 1 ine rr-hydroxy ornithine 1 1 1 1 2-hexanoic acid such as D-glucohexose Acid or D — galactosyl hexonic acid 1 1 [a -amino — β monothiol • such as cyanogenin amine β monothiol provaline i 1 1 acid or linyl thiobutyric acid [| Other Contains Thiamin residues include cysteine homocysteine β — 1 I benzylthiomethionine > S — allyl — L Cysteine mill 1 1 I 2 —thiol histamine cysteine 1 and cysteine or homocysteine 1 1 This paper size applies to Chinese National Standard (CNS) Λ4 specification (2 丨 〇297 Mm) -75 4 2 66 6 3 a7 __A______B7_ V. The thiol ester of the description of the invention (73); Phenylalanine 'leucine and ring-substituted α-amino acids, such as phenyl- or cyclohexylamino acids α-Aminophenylacetic acid, α-Aminocyclohexylacetic acid and σ-Amino-1 / 3-cyclohexylpropanoic acid; phenylalanine analogs and derivatives, and containing aryl'low alkyl'hydroxyguanidine groups , Oxyalkyl ether, nitro, sulfur or halogen substituted phenyl (for example, glutamic acid, methyltyrosine and o-chloro-1, p-chloro-1, 3,4-dichloro-, o-one, m-one or Monomethyl-, 2,4,6-trimethyl, 2-ethoxy- 5-nitro-, 2-hydroxy-5-nitro- and p-nitro-phenylalanine): furanyl-, sleep Phenyl-, pyridyl-'pyrimidinyl-, purinyl- or fluorenyl-alanine: and leucine analogs and derivatives' include kynurenine, 3 Hydroxy kynurenine, 2-hydroxyalkyrosine and 4-monocarboxyleucine; α-amino-substituted amino acids, including sarcosinic acid (N-methylglycine), N-benzylglycine Acid, N-methylalanine · N-benzylalanine, N-methylphenylalanine, N-benzylphenylalanine, N-methylvaline and N-benzylvaline; Central Standard of the Ministry of Economic Affairs Bureau's Consumer Cooperative printed alpha-hydroxy and substituted alpha-hydroxy amino acids including serine, threonine, allurin, phosphinoserine and phosphinothreonine. Polypeptides are polymers of amino acids in which the carboxyl group of one amino acid monomer and the amino or imine group of the other amino acid monomer are bonded together by an amidine bond. Polypeptides include dipeptides, low molecular weight polypeptides (approximately 1 500-5 0 0 MW), and proteins "proteins may optionally contain 3 * 5, 10, 50, 75, 100 or more residues, and are preferably Ground proteins are essentially sequence congeners with humans, animals, plants or microorganisms. The paper ruler is in accordance with the Chinese National Standard (CNS) A4 (_210 × 297 mm) -76 — 426663 A7 B7 Printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs 5. Description of the invention (74) Including enzymes (eg, hydrogen peroxide Enzymes) and immunogens (such as KLH), or antibodies, or any type of protein that can produce an immune response due to confrontation "The properties and identification characteristics of these polypeptides can vary widely. This peptide ammonium is used as an immunogen and Improving the antibody against the polypeptide (if it is not immunogenic in the animal being treated) or against epitopes on the remainder of the compound of the invention. It can be bonded to the parent compound without the peptidyl group Antibodies can be used to isolate the parent compound from a mixture, for example, in diagnostics or when the parent compound is prepared. The conjugate of the parent compound and the polypeptide is usually more immunogenic than the polypeptide in the near-animal, so The polypeptide is more immunogenic, making the antibody more resistant to it. Therefore, the polypeptide or protein is in an animal (eg, rabbit, mouse, horse, or rat It does not need to be used to elicit antibodies for immunogenicity, as long as the final conjugate product formed in at least one of the animals is immunogenic. The polypeptide is arbitrarily between the first and second residues adjacent to the acidic heteroatom. The peptide bond contains a peptolytic enzyme cleavage site. This cleavage site is attacked laterally by an enzyme recognition structure, for example, a specific residue sequence is identified by a peptolytic enzyme. Peptide solutions used to cleave the polypeptide conjugate of the present invention Enzymes are well-known, especially including carboxypeptidases. Carboxypeptidases break down polypeptides by removing carbon-terminal residues (and in many cases, specific for a specific carbon-terminal sequence). The requirements for such enzymes and their substrates are generally It is known that, for example, a dipeptide (having a specific pair of residues and a free carboxyl terminus) is covalently bonded to the phosphorus or carbon atom of the present compound with its α-amino group. In the case where Wi is a phosphate, this is expected The peptide will be cleaved by appropriate peptide solutions, leaving the proximal (.proximal) amino acid residues. Please read the note on the back and fill in again. —— Binding on this page: The standard of wood paper is applicable to Chinese national standards ( CNS) A4 specification (21 0X297 mm} -77-A7 B7 4 2 6 6 6 3 V. Description of the invention (75) Carboxylic group catalyzes the phosphoamidite bond. A suitable dipeptidyl group (listed by its single letter code) is AA, AR, AN, AD, AC, AE, AQ, AG, AH, AI ,. AL, AK, AM, AF, AP, AS, AT, | AW, AY, AV, RA, RR, RN, RD, RC, RE, RQ, RG, RH, RI, RL, RK, RM, RF, RP ,; RS, RT, RW, RY, RV, NA, NR, NN, UD, NC, NE, NQ, NG, NH, NI , NL, NK, 1 NM, NF, NP, NS, NT, NW, NY, NV, DA, DR, DN, DD, DC, DE, DQ, DG, DH, DI, DL, DK, DM, DF, DP, DS, DT, DW, DY, DV, CA, CR, CN, CD, CC, CE, CQ, CG, CH, Cl, CL, CK, CM, CF, CP, CS, CT, CW, CY, CV, EA, ER, EN, ED, EC, EE, EQ, EG, EH, El, EL, EK, EM, EF, EP, ES, ET, EW, EY, EV, QA, QR, QN, QU QC , QE, QQ, QG, QH, QI, QL, QK, QM, QF, QP, QS, QT, QW, QY, QV, GA, GR, GN, GD, GC, GE, GQ, GG, GH, GI , GL, GK, GM, GF, GP, GS, GT, GW, GY, GV, HA, HR, HN, HD, HC, HE, HQ, HG, HH, HI, HL, HK, HM, HF, HP , HS, HT, HW, HY, HV, IA, IR, IN, ID, IC, IE, IQ, IG, IH, II, IL, IK, IM, IF, IP, IS, IT, IW, IY, IV , LA, LR, LN, LD, LC, LE, LQ, LG, LH, LI, LL, LK, LM, LF, LP, LS, LT, LW, LY, LV # KA, KR, KN, KD, KC, KE, KQ, KG, KH, KI, KL, KK, KM, KF, KP, KS, KT, KW, KY, KV, MA, MR, MN, MD, MC, ME, Ma MG, MH, MI, ML, MK, MM, MF, MP, MS, MT, MW, MY, MV, FA , FR, FN, FD, FC, FE, FQ, FG, FH, ¥ 1, FL, FK, FM, FF, FP, FS, FT, FW, FY, FV, PA, PR, PN, PD, PC, PE, PQ, PG, PH, PI, PL, PK, PM, PF, PP, PS, PT, PW, PY, PV, SA, SR, SN, SD, SC, SE, SQ, SG, SH, SI, SL, SK, SH SF, SP, SS, ST, SW, SY, SV, TA, TR, TN, TD, TC, TE, TQ, TG, ΤΗ, TI, TL, TK, TM, TF, TP, TS , TT, TW, TY, TV, WA, WR, WN, WD, WC, WE, WQ, WG, WH, WI, WL, WK, WM, WF, WP, WS, WT, WW, WY, WV, YA , YR, YN, YD, YC, YE, YQ, YG, YH, YI, YL, YK, YM, YF, YP, YS, YT, YW, ΥΎ, YV, VA, printed by the staff consumer cooperative of the Central Standards Bureau of the Ministry of Economic Affairs VR, VN, VD, VC, VE, VQ, VG, VH, VI, VL, VK, VM, VF, VP, VS, VT, VW, VY: and vv. Tripeptide residues can also be used as Reb or Re. * When Wi is a phosphonate, —X4— pr ο— X5 — (where X4 is any amino acid residue, X 5 is an amino acid residue, a carboxylate of proline, or hydrogen) will be blocked The luminal carboxypeptidase is cleaved to X4, which has a free carboxyl group, and is expected to autocatalytically cleave the phosphoamidine bond. The carboxyl group of X 5 is arbitrarily benzyl esterified. __ This paper size applies to China Standards (CNS) A4 specifications (210X 297 public broadcasting) -78-Printed by the Consumers' Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs 4 2 ^ 663, a7 _____B7__ V. Description of the invention (76) According to known transmission properties and / or peptides Enzyme sensitivity. (It can affect the transmission of intestinal mucosa or other cell types.) Select the type of dipeptide or tripeptide. Dipeptide or tripeptide lacking α-amino group is found in the brush shape of intestinal mucosa cells. Peptide transporters in the boundary membrane serve as a transfer matrix (Bai, JPF, " Pharm Res, 9: 969-978 (1992). The transfer component peptide can be used to enhance the bioavailability of the amidated compound. It has one or more Diamino or dipeptides of amino acids that are D-configured can be used in the amidine compounds of the present invention. D Configuration Amine Acids also reduce the possibility of di- or tripeptides to be hydrolyzed by proteases (the proteases are common in brush borders, such as aminopeptidase N (EC 3.4.11. 2)). In addition, dipeptides Or tripeptides are selected for their relative resistance to proteolytic hydrolysis in the intestinal lumen. For example, a tripeptide or peptide lacking asp and / or g 1 u is a poor matrix for aminopeptidase A (EC 3.4.1 1. 7) ; The dipeptide or tripeptide lacking amino acid residues at the nitrogen end of the hydrophobic amino acid (leu, tyr, Phe, va 1, trp) is a poor matrix for endophthalase 24.11 (EC 3.4.24.1 1) ; Peptides lacking pr 0 residues at the penultimate position of the free carboxy terminus are a poor matrix for carboxypeptidase P (EC 3. 4. 17). Similar tests can also be applied to select more difficult or easier to be selected Nucleus "Peptide hydrolyzed by kidney, liver, serum or other peptidases" This kind of peptide ammonium which is not easily cut off is an immunogen or can be used to bind to a protein to make an immunogen. Another embodiment of the present invention For example, the composition of formula (ΥΠ) or (VII): The standard of China's national standard (CNS) Α4 (210 ^ 297 mm) is applicable to __ (Please read first) Note # face of reloading the page) loaded - the licensing · -79 - A7 B7 4 266 6 3 V. invention is described in (77

la

Ei where E:!, Gl ’Ding 1’ Ul ’J 1’ Jla ’Ja and] 2a are as defined above, except the following:

Tl is a heterocyclic ring, or combined with Gi to form a group of the formula >

Reb'N:: and

V fork: for bonding, —0 one, _N (H)-,-N (Rs)-, one S —, — SO —, or one S02 —; but does not include '[^ 为! !! Or -c H 2 CH (OH) CH2 (OH) compounds; printed by the Ministry of Economic Affairs, the Central Bureau of Standards, and printed on its salts and intermediates by consumer cooperatives; resolved stereoisomers;体 物。 Structure. The typical or general specific examples of the formulas (I) to (V I) detailed above are also typical specific examples of the formulas (νπ) and (vm). The synthesis of many compounds of formula (νπ) and (vm) (where Ui is η or -CH2CH (OH) C_H2 (OH)) is found in

Nishimura, Y. et al. 1 · Antibiotics. 1 9 9 3, 46 (2), 300; άΜ 1 2), 1 8 8 3; and Nat. Prod. Lett. 1 9 9 2, 1 (1) The paper size applies the Chinese National Standard (CNS) A4 ^ (21〇X 297 mm) -80-Printed by the Consumers' Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs 4 2666 3 ^ A7 ________B7 V. Description of the invention (78), 39. The method of the present invention is as described in this article. Stereoisomers_ The compounds of the present invention are enriched or resolved optical isomers on any or all of the asymmetric atoms. For example, in the representation In the method, it is obvious that the palmar center system is a palmar isomer or a racemic mixture. A racemic mixture or a non-mirror stereoisomer mixture, and each optical isomer that is isolated or synthesized (substantially does not contain its mirror image). Or non-mirror stereoisomers) are within the scope of the present invention. Racemic mixtures are separated into substantially optically pure isomers according to known techniques, for example, with optically active adjuvants such as acids or bases ) The non-mirror stereoisomeric salt formed is separated and then converted back to the original In most cases, the expected optical isomers are synthesized by stereospecific reaction, that is, the reaction starts with the appropriate stereoisomer of the expected starting material. ♦ The stereochemistry of the compounds of the present invention is illustrated below. Table C》

Table C

E1 G⑴

CM The paper size is in accordance with the Chinese Standard (CNS) A4 specification (210X297 mm) 81 4 2 6 6 6 3 ^ at B7 V. Description of the invention (79) Formula (I)

El Jla Jib Ul Tl Gi one one α a a--[i a a a one one [a 13 ti a-— a a 15 < x a a a ϋ a h a formula (I)

El Jla Jib J2 Ul Tl Gi — aa Ϊ aaaa li aa ~ a β ϋ aaa-a β a ϋ | 1 a _ a β a li a | 3 iaaaa-ia Γα 3 li a-iaa ϋ a β a Ιχ. Ia ti a ~ · a 「β Γ aap ~ aa ϋ li μ aa (ia ~ a ii a (3 aa li [J — apa li i— | ia (ia ΐ—τη (Please read the precautions on the back before this Pages). Packing · 'Ordered by the Consumers' Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs, the compounds of the present invention may also be tautomeric isomers in some examples. For example, miso 'vein' a fat and four miles. The system can present ene-amine tautomers, and all possible tautomers are within the scope of the present invention. Exemplified compounds are shown on the paper. The paper size applies to the Chinese National Standard (CNS) Λ4 specification (210X297 mm). ) Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs λ 2 6 ^ ^ ^ Λ Α7 ._B7 ___ V. Description of Invention (80) Specific examples of compounds are listed by way of example rather than limitation. Table E (Table 6) Often, each compound table is a substituted core (cores are capitalized The parent table), and each group is substituted with a lowercase letter or sequence number table

〇 Table 1 a and 1 b The table of each core. The main difference is that each core reads 1 1 1 the unsaturated position on the ring of the heart and the nature of the substituents on the ring. 1 a and 1 b are given-a letter code, and this code is the first letter of the 1 I name for each compound • Similarly, Table 2 a — 2 V * 3 a — b Ψ and then if-1 4 a-C and 5 a-d list the selected QX 'Q 2 Q 3 Q 4. Take this 4 I generation base as well * is the j electric letter or number code. Therefore, each compound named 1 1 I will be represented as: _ ~ · uppercase letters to represent the core of 1 1 I in Tables 1 a-1 b followed by the numbers of the substituents of Table Q i, which represent the substituents of Q 2 No. 1 1 lowercase letter represents Q ϊ Substituent number represents Q 4 substituent letter lowercase i letter 0 So the structure 8 in the reaction diagram 1 is A. 4 9 a 4-1 | i should understand Q 1--Q 4. It is not a group or an atom, but a related expression. 1 J The paper size of the paper is applicable to the Chinese National Standard (CNS) Λ4 specification (210 × 297 mm) 4266 6 3; A7 B7 5. Description of the invention (81 Table la from 〇1

q2

•: q3d "Ya q3g Q4N-N 2 4 〇 = 1Q1Q1

Q2 q202

3 • -Q

J Printed by Cooperatives, Staff of Zhongli Standards Bureau, Ministry of Economic Affairs Q1 9hn

Q2q2 3T-0M

3 two a p

This paper size applies the Chinese National Standard (CNS) Λ4 specification (210X29hi—death) ~ 84-426663. V. Description of the invention (82 table lb A7 B7 cv

Q Q;

〇4

Oq2

S

T 〇3u 〇4 Printed by the Consumer Cooperatives of the Central Bureau of Standards of the Ministry of Economic Affairs _ &r; 〇3 v This paper size applies to the Chinese National Standard (CNS) Λ4 specification (210X297 mm) —85 — 426663 A7 B7 Printed by the Employee Consumption Cooperative V. Description of the Invention (83) ^ 2a HQ, H3C-Q1 h3c ^^ Qi 1 2 3 4 h3c t > ^ Qi h3c * / 'v' ^ q1 H3C H3C ^ Qi 5 6 7 8 h3c y H3c < > -Qi 〇h3c ^ AQi 9 10 11 12 h3c / v ^ / ^ 'q1 h3c ^ 1Qi h3c H0Y ^ 0 13 14 15 16 ho ^^ Qi h3c ^ Qi OH ho々Y. 1 h3c 17 18 19 20 h3c- ^ y ^ 'q1 OH OH HO HaC HO ^ Ql 21 22 23 24 4' 4 2 66-6 3 A7 B7 V. Description of the invention (84 Table 2b h3c ho ^ yQi OH OH HO ^ ^ Q 25 26 27 28 〇 h3c 〆 〆 OH OH 0 H3Ci ^^ Q1 〇ho- ^ y ^ Qi h3c 29 30 31 32Institute of Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs h2n-^^ Qi η2ν ^ ν λλ- Qi nh2 h3c 33 34 35 36 nh2 nh2 H3C ^^^ Q1 H2N. H3C ^ AQi H3C I 37 38 39 40 h3c h2n ^ Y ° 1 0 h3c Jin Qi nh2 〇41 42 43 44 〇h3c ^ Y ^ Qi nh2 nh2 0 〇h3c 0 0 HO people ^ 45 46 47 48 This paper is applicable to the national standard (CNS) Λ4 specification (2l () X297 mm) -87-426663. Jk V. Description of the invention (85 Table 2c A7 B7 HO ^ Y ^ Q! OH 49

HO

HO

Qi

OH

HO H3C

〇1 OH 52

Qi

50 HO. HO ～ 53 O H3〇 ^ T 'Q1 OH 51

H, C

Her ya * Q! OH

OH

54 OH Q

H3C ~ Ya Q! OH

O HO

Qi OH

56 OH O 57

Qi 58 NHa

59 H2N

h2n 〇1

O

Qi 2

Printed by Shellfish Consumer Cooperative, Central Standards Bureau, Ministry of Economic Affairs 61 62 h2n

H3C

〇1 nh2 64 H2N) 65

h3c ^ t Q1 nh2 63 H3C H2ir ya * Q! NH2 66 This paper size is subject to the Chinese National Standard. (CNS) Λ4 Specification (2) 0X 297 mm) -88-426663 A7 B7 Staff Consumption of the Central Bureau of Standards, Ministry of Economic Affairs Printed by a cooperative

Printed by the Consumer Cooperatives of the Central Bureau of Standards of the Ministry of Economic Affairs 4 2 6 6 6 3 .. A7-AA 7 ___ B7 _ ^ _ V. Description of Invention (87) Table 2e OH Ο NH2 87 H2N ^ Qi o 90 NH 93 NH i H2N Guang Q , 96 H3C, 〇Q1 H3C ^ ° ^ n'Q1 97 QiY ^ ch3 Qivy ^ ch3 ch3 ch3 100 101

98 〇CH3QlX H3C CH3 102 (Please read the precautions on the back of the page before / this page) This paper size applies to China National Standard (CNS) A4 size (210X 297 mm) -90-126663 Λ κι B7 V. Description of the invention (88 Table 2f Qr 'CH3 ch3 ch3 103 104 105 ch3 ch3 Qi ch3 ch3 Printed by the Consumers' Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs Qj-106 107 108 ch3 q ^ ch3 ch3 ch3 QiV ^ ch3 ch3 h3c' ch3 q ^ ch3 109 110 111 QiX ^ ch3 h3c ch3 Factory ch3 Qi-K ^ ch3 112 113 114 QiV ^^ ch3 ch3 QiV ^ ch3 ch3 ch3 Qi \ ^ C ^ CH3 115 116 117 ch3 Qi ^^^ ch3 Qi \ ^ Y ^ CH3 ch3 Qiv -^ V ^ ch3 ch3 118 119 120 (Please read the notes on the back # ._ Each page on this page) This paper size is applicable to China National Standards (CNS) Λ4 specifications (210 乂 297 mm) 426663: * 五 、 Description of the invention (89. test 2g A7 B7 ch3

Qi CH3

ch3 122 CH, 121 £ 'CH3 123 H3C ch3 CH, Q-

CH, CH3 QH3 CH ^ 124 125 126 CH3 ch3 qh3 Qi vv ^ \ / CH3 ch3 ch3 ch3 127 128 129

This paper size applies to Chinese National Standard (CNS) Λ4 specification (21 × 297 mm)-92-A7 B7 ¢ 26663

A V. Description of the invention (9 (5 Table 2h ch3 ch3 h3c ch3 -CH3

139 140 141 ch3 142 Q1◦ H 3 ch3 143 (Please read the precautions on the back page first). Installation. Q1c h 3 ch3 Q! H 3 144 145-Order QH3 Q1 146 Q1 h3 ch3 147 ch3

CH 3 Printed by the Consumer Standards Cooperative of the Central Bureau of Standards, Ministry of Economic Affairs 148 149 QH3 150 Q-j *

, CH 3 CH, 151 This paper size applies to Chinese National Standard (CNS) Λ4 specification (210 × 297 mm) A7 B7 426663 ^ V. Description of the invention (91 Table 2i

ch3 3 〇1, CH3 153

QiV ^^ ch, h3c ch3 '154 CH Qi

CH, CH3 nu

CH3 CH, nu Qi

CH3 CH, 〇1 155 156 157 ch3 v ^ / v'ch3 ch3 〇ΐΥΎ ^ 〇Η3 ch3 ch3 Qivy ^ V ^ ch3 ch3 ch3 158 159 160

Qi This paper size is applicable to National Standards (CNS) A4 (210X W7 mm)

QiV ^ Y ^ chs ch3 ch3 i i ΟΠ3 ch3 ch3

ch3 ch3 ch3 161 162 163 CH,

Q Printed by the Consumer Cooperatives, Central Operations Bureau, Ministry of Economic Affairs

Qi ch3 ch3 Q1

165 CH3 ch3

Q 164 166 h3c, ch3 167 'CH, CH Qi

CH3 ch3 nu Qi

ch3 ch3 168 169 4 2 66 6 3 4 V. Description of the invention (92 Table 2)-nu o ^ A7 B7

ch3 CH3 170 CH Έ a CH3 ch3 171

Q

CH3 CH 173 Q1 3 '^ V ^ CHc h3c ch3, Q1

174 ch3 ch3 ch3 175 Q1 ch3 176 9 ^ 3 ch3

Q1, / s ^ CH, CH

'3 177 3

h3c々ch3 179 h3c ^ ch3 CH3Q, A ^ CH3

CH3 Printed by Shellfish Consumer Cooperative, Central Bureau of Standards, Ministry of Economic Affairs 182 QH3Q1H3 ch3 185

Qi-^-\ ^ ch3 h3c / v-ch3 Q1 180 181 ch3 Qi, ch3 'ch3 ch3 183 184 W3 186 187 ---------. 丨 ^ ------? Τ --- --- m (read the notes on the back first and then read the Or page) The paper size applies the Chinese national standard (cns) Λ4 gauge · grid (2.0 × 297 mm) -95-4 2 6 6 6 3 5 Description of the invention (93) βζ 2kQ ^^ X ^ CH3 188 A7 B7 ^ 3 ^ \ ^ ΟΗ3 Q1 Η3 189 h3c,

190

Please read the note of memorandum before kj

h3c ch3 h3c, ch3QiCxLcH3

195 1Τ

This paper size applies to China National Standard (CNS) Λ4 specification (210X297 mm)

This paper size applies to China National Standard (CNS) A4 (2! 〇XW7 mm)-97-4 266 6 3. A? 4 B7

This paper size applies the Chinese National Standard (CNS) Λ4 specification (_ 210X297 mm) V. Description of the invention (95) 98 4 2 6 6 6 3 V. Description of the invention (96) Table 2n A7 B7 ch3 ch3

Qi 'H3C, ch3

Qi H3c QH3

ch3 ch3 ch3 241 242 243 H3C, H3C- ^ H3C), ch3 'ch3 h3c’ch: 244 245 246 h3c Q-

CH, CH, h3c Qi

A CH3 ch3 h3c 'Qi

CH3 ΌΗ, 247 248 249 H3C 'Qi

k ch3 ch3 250 H3C ^ CH3 Qi

CH3 H3C ^ .CH3

ch3 251 Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs

252 Qi H3C

CH 3 h3c

Qi h3c

/ ch3 ch3 256 CH3 254 257 255 \ ^ CH3 258 This paper size applies to Chinese national standards. (CNS) Λ4 size (210X 297 mm) -99-426663v B7 Printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs

426663 ^ V. Description of the invention (98 Table 2P A7 B7

ch3

Qi

3 'CH, 278, ch3

H3Cy CH3 η3〇 ^ 281

(Please read the precautions on the back n-install-r this page) ch3

rCH3

Q ch3

H3cr 285 1 ^^ Y ^ CH3 h3c into ch3 288 Order printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economy

Q

Q 1 ^^ y ^ ch3 H3dH3 289 ch3 kCH3 292

Q

a I 'ch3 CH3' CH3 291

Q QH3 tv- ^ S ^ CH3, h3 293

This paper scale applies to China's national standard rate (CNS) Λ4 now (2 丨 OXW mm) 4 2 ^ 6 6 3 A7 _ * ___ B7

This paper size is applicable to China National Standards (CNS) 6 4_present grid {21Ό X 297 mm) 5. Description of the invention (99) ^ 2q '-102-A7 B7 5. Description of the invention (1G ()) Table 2r

CH3 ch3

315

i i ^ Γ, 3 ch3 ch3 314 H3Cv pH3pH3 'CH3 317 ch3 ch3

ch3 ch3 319

ch3 i i ΟΓΊβ ch3 ch3 321

〇i ^ ch ^ ch3 ch3 CH, CH3 ch3

323 Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs

CH3 Qi \ ^, CH3 h3c Ch ^ h3 328

CH 3 324 CH3h3c ch ^ ch3 327 — Staple „、-. (Please read the precautions on the back first. ¾ Write this page) h3q ch3

ch3 ch3 329 H3C, CH3 '' ch3

This paper size applies to China National Standards (CNS) Λ4 specifications (2l0X 297mm) -103-4 2 66 6 3 Λ: V. Description of the invention (1G1) 峩 2s' CH3Qi ^ X / CH3 CH, CH3CH3 A7 B7 Ί3 'ch3 〇ι ^ Λ > η3 CH3 332

Q Fork 3c1V > (ch3 ch3 333 331 CH ^

ch3 337 Qi \ ^^ CH3

C

CH, C

(Please read the precautions on the back before filling this page) M pack.

41T

Η3〇Τη ^ 3 h3c ^ ch3 340 341

9 ^ 3

Printed by Qiongdong Consumer Cooperative, Central Standards Bureau, Ministry of Economic Affairs i CH3Η # 1ίΗ3 343

QiH4 »h3 h3c ch3 346

Qr, ch3 <, ch3 ch3 ch3 H3q Qi

ch3 ch3 i 'CCH: 3 344 345 n CH3 mQiX ^ ch3 h3c CH3CH3 347

This paper size applies to Chinese National Standard (CNS) A4 specification (2 丨 0X 297 mm) 104 Printed by the Central Standards Bureau of the Ministry of Economic Affairs and Consumer Cooperatives 4 2 666 3 / V. Description of the invention (1G2) Table 2tH C 9H3 Η3 ° ^ 0Η3 〇1 T " ch3 ch3 349 HC ch3 H3US-ch3 Qi '^ ch3 ch3 352 A7 B7 h3c ch3 Q1

ch3 ch3 ch3 350 h3c ch3 μ p 9% H3CS-ch; QiVAch3 ch3 351

Q ch3 ch3iOOrCH; ch3 355

358

f ch3 ch3 i ch3 353 354 qh3 ch3 H3C, pH ch3 356

CH3 ch3

This paper size applies to China National Standard (CNS) A4 (2I0X 297 mm)

363 I.. »1 M (II " " Order. .R (Please read the notes on the back before filling this page) CH,

CH 3

CH3 -105-4 2 6 6 6 3 ^ V. Description of the invention (103) Table 2u A7 B7

CHc k / CH3 ch3CH, Q. 368 CH3 ch3 ^ 〇h3 oh3 369

CH 3

372 (Please read the precautions on the back v 370

371

CH3: Install-r this page) Order 373

ch3 ch3 Gland Inst. of Consumer Cooperatives, Central Standards Bureau, Ministry of Economic Affairs

379

383

H3C

This paper size applies Chinese National Standard (CHS) A4 specification (2 [〇X297mm] 426663 ^ V. Description of invention (1G4) Table 2v A7 B7

ch3

ch3 ch3 '' -CH3 ch3 ch3 ch3 388

CH3 ch3 Q i h3 Cl-c \

CH, h3c, a ~ ch3 390 (Please read the precautions on the back before this page).

391

Ding -5

Printed by the Staff Consumer Cooperative of the Central Bureau of Standards, Ministry of Economic Affairs

ύ. CH3 ch3 ch3

ch3 ch3 397 kCH3 398

H3C 399 This paper size is applicable to China National Standards (CNS) Λ4 specifications (2.0 × 297 mm) -107-426663 A7 B7 V. Description of invention (1D5) Table 2w · CH3 ch3 400 401 402 αΐ'Ύ ^ ch3 M.n

405 Q1 C H 3 403 404 406 ch3 〇1Ύ ^ ΟΗ3 ch3 ch3

CH 3 407 408 409 410 CH3 Qi " ^ CH3

Qi'n ^ JL CH, ch3 411 412 413

This paper size applies to the Chinese national standard {CRS) A4 (21〇 × 297 mm) -108-426663; V. Description of the invention (1 () 6) Table 2x CH3 420 A7 B7 ch3 421 h3c ^ ch3 Qr 422

ch3 CH Qi

3 ch3 423 ch3 424 425

Q 426

Qi ~ ^^ ch3 427

Qi

428 pHa

Qi

429

CH 3 PH3 430 PH3 Q-ι1 i, m, < C] 431

This paper size applies the Chinese National Standard (CNS) Λ4 specification (2l0X297 public holiday) -109-Α7 Β7 V. Description of the invention (1 (ϊ7) Table 2y Q1V > CH3 rCH, 440

Qi々 ^^ CH3 ch3 441 " / yCH, 442

'CH, Qi 444 445 446 Factory CH3 Factory Ch3 Qi 〇i ^ <] Q1… <] 1

CH-, CH, 448 449 450

PH3

Qi CH, Q1V_CH3

452 453 454 Printed by the Consumers' Cooperative of the Central Bureau of Standards, Ministry of Economic Affairs ch3 ch3 9H3 Q, < ^ > Q1ό 456 457 458 460 461 462 Factory CH3

This paper size applies to China National Standard (CNS) A4 (210 X 2W mm) -110-4266 6 3 ,: A7 ___B7 V. Description of Invention (1G8) Table. Printed by the Central Standards Bureau of the Ministry of Economic Affairs system

I Order-(Please read the precautions on the back first and then continue on this page) The paper size is in accordance with the Chinese National Standard (CRS) Λ4 specification (210 × 2 [> 7 male thin) -111-426663 j B7 Central Ministry of Economic Affairs Printed by Shell Bureau Consumer Cooperative

A7 B7 4 ^ 66 6 3 ^. V. Description of the invention (110) Table 2ab

Qi κ 'CH; CH,

pn3 CH3 Q1 »-< ^ ch3 -ch3 CH,

508

CH 3 505 506 507

‘Ch pH V—i

々 一 CH3 510 511 pH3 〇1-Κί 〇! ^ -CH, 509 CH, Q / " 1 CH3 ^ -CH3 512 ^ — Qi

^ H3 pH3 CH3 H3C

Qi1 " ... <] Q, — <] Qi " X ^ CH '—CH3 V—ch3% ~ ch3 513 514 515 516 h3cx h3c h3c y ~ CH3) -CH3) -CH3 〇! Qi_ · .. <] Qi ^ O Q1 " ... · <] 517 518

519 520 Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economy Q ch3 ch3 521 522 〇1 CH,

ch3 524

CH, v CH3 525 526 527 This paper size applies to Chinese National Standard (CNS) Λ4 size (2l0x2y7 mm) 113 426663 A7 B7 V. Description of the invention (nl) Table 2ac .ch3 γυ0Η3

528 ch3 Qi ·

4 530 h3c

H3C ch3 / 6 QH3

529 CH 531 3

Qi h3c

532

Qi h3c

533

Ql ^ O ^ CH3 h3c h3c 534 535

Q ^ CH33 537 CH,

ch3 CH,

CH3 Qi— < VCHg Q CH, 4 * ch3 Printed by the Staff Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs 541

H3 This paper size applies to China National Standard (CN \ S) Λ4 specification (210X297 mm) -114-4266 6 3, A7 B7 Clarification (ll2) Table 2ad / CH3 / CH3 f = / V CH QiK > Qi -&54; 50 Q1 c Q1

Q1

H3 C 55 53

Q

c1 / < 3III * Hs- ¾ Q1 54Q1 55 55 55 1 I * —. ^ Water:.. ~ " Order (Please read the precautions on the back before Ci page) '

Q

H3 i *

Q 9 H3

Q ο H3 5 5 60 56 62 Line Printed by the Central Standards Bureau of the Ministry of Economy—Industrial and Consumer Cooperatives

Q

63

Q

Q

H3c 64

Q

Q

56

〇

3 Hc This paper size is in accordance with Chinese National Standard (CNS) A4 (2! 〇 X 297 mm) c 3 5: H56 Η3c 66

Q \ 3 CTC569 ii 266 6 3 A7 B7 V. Description of the invention (113, Table 2ae ch3 ch3 570 571 572 Q ~., 0CH3 Q1 ^ 0 ,, CH3 573 574 575 CH 3 'CH 3

Ql ^ CH3

Please read% Note's note first before 576 577 578 579

Qy,. ^, CH3

CH, 580 581 ch3 582

Qn, CH, 3 583 Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs CH, 584 ch3 588

Qi

CH3 585 CH3 586 Q1 ^ 0, CH3 587 Q ~ ’CH3 ⑹WCH, 589 590 This paper size is applicable to China National Standards (CNS) Λ4 this grid (210 X 297 mm) -116 4 2 66 6 3 r at B7

This paper size applies the Chinese National Standard (CNS) Λ4 specification (210χ2 () 7mm) V. Description of the invention (114) -117-4 2 6 6 6 3;: A7 B7

This paper size applies to China National Standard i CNS) Λ4 specification (210X2V7 mm) -118-4 266 6 3 ν 5. Description of the invention (116) A7 B7 Table 2ah

, CH3 ch3

CH, ch3 ch3

Qi GH, r ^ \ (628 629 630 w〇, C 631 Ch ^ O ^ 632 factory '▽ .〇633, guang ⑶3 ,,, ch3 Qij 634 635 636 637 638 639 639' CH, please read the back & Matters needing attention are again printed by the Consumer Cooperative of the Central Bureau of Standards

This paper size applies to Chinese National Standard (CN_S) A4 specification (210X297 mm) -119-426663 A7 B7 V. Description of the invention (1Π) Table 2ai

I ch3

Qi 648 649 H3C 650

CH,

Q !, person / 7CH3 653

Qi ch3 654

CH 3 Please read the notes on the back first, and then S. This page is printed by the Staff Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs.

This paper size applies the Chinese National Standard (CNS) Λ4 specification (210X 297 mm) line -120-4 2 66 6 3 λ; 5. Description of the invention (118) A7 B7 Table 3a 〇 〇2-i

OH 〇2 ^ (O-CH3

Oo

OH 〇

〇, CH3 〇 a c d Printed by J Industry Consumer Cooperative, Central Bureau of Standards, Ministry of Economic Affairs

OH o

〇 ^ / 〇H f ^ P \ 〇H 〇2q

〇-CH3 O-CH3 〇2 The paper size is applicable to the Chinese National Standard i CNS) Λ4 is present (21〇X 297 mm) 121 4 2 66 6 3 v 5. Description of the invention (119) Table 3b A7 B7

H H. N. ^

N Q2

N 3V. H-i ^ o 02

Η 丨 N

H3 C ό .ο " ο s u

V H3 h3c / Ν ΝΛ 020

O% o > c3 H Q2 o A- w

X CHy

Η3 o c% oy, c3 H z ---------- install — 3 (please read the precautions on the back before this page) o% o, 3 H c

oH3% 4 3 H

o Q o

H c o 2) = (Q (

H3C H3 c

B c

D gland Q2 Co-operative printed by employees of the Central Standards Bureau of the Ministry of Economic Affairs

3 H c

3 3 Η H c: c

E

F This paper size applies the Chinese National Standard (CNS) Λ4 specification (210X297 mm) 122 4 2 6 6 6 3 Α- 一 A7 B7 V. Description of the invention (120) Table 4a Q3-〇H q3-n3 q3--n〇 2 q3-nh2 1 2 3 4 q3々nh2 q3 ^ nh2 ch3 1 q3 * nh2 q3 ^ h2n > 5 6 7 8

The scale of this paper applies to the Chinese National Standard (CNS) Λ4 specification (2〗 0κ297 mm) (Please read the precautions on the back before filling in this page)

-123-4 ^ 6 b 6 3 Λ: V. Description of the invention (121) Table 4b A7 B7

nh2 〇3 〇3 〇Η Α ^ -ΝΗ2 nh2 〇3 ^ 〇H Q3 " ^ Y ^ NH2 OH 26 27 28 OH NH〇 OH '〇H Q3 nh2 q3-, CH3 nh2 q3 29 NH2 OH 33

CH3 30 31 32

q3-cn NHJ1 S NH2 35 36 Order VH37 — \ ° 3 Η2 Ν

Η2 ΝΗ. ^ VC r Q 2 νηη: YS Ν H2 N Λ Ν Ν 38 39 40

^ ^ 3 / Ν QIN C 03— ^ Η 41 42 ° 3 Η—Ν Η3 C Ν Η 2 Ν τ Q3 Η—Ν 44 This paper is suitable for China National Standard (CNS) Λ4 specification (21 〇X 297 mm) 〆Η 43 3 Η C2 Η C Ν ^ ΤΝΗ 45 -124-4 266 6 3 A7 B7 V. Description of the invention (122,

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NH 2 49 50 51 H3 Η3, ΌΗCIN 〆Q3 5 52 ^ ch3 q3 / n \ ^ ch3 53 Printed by the China Consumer Standards Cooperative Standards Bureau of the Ministry of Economic Affairs This paper is printed in accordance with Chinese National Standards (CNS) M specifications (210x297 mm) ) _ I Η-Q4 H3C-Q4 A7 B7 h3c ^ q4 wide q4 ch3 ch3 1 h3c wide q4 abde

This paper size applies the Chinese National Standard (CNS) A4 specification (2 〖〇X 297mm） 4 2 66 6 3 Λ _ 5. Description of the invention (123) Table 5a -126-426663 A7 B7 5. Description of the invention (124) Table 5b CH3 〇HH3CXn, q4O ', 0 ch3 h S, s,: n, q4 h3c Seven s,: n, q40, 〇0 〇

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This paper size applies to the Chinese National Standard (CNS) A4 (210X297 mm) Λ266 6 Α7 Β7 V. Description of the invention (125) Printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs

This paper is a national standard suitable for rich countries (called Juge (plus X 2 gift) _ 426663 A7 B7 Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs 5. Description of the invention (126) Table 6-Exemplary Enumerated Compounds A.17.a .4.i; A, 17.a.4.v; A.l7.a.6.i; A.17.a.6.v; A.17.a.ll.i; A.17.aHv ; A.17.a.l4.i; A.17, a.l4, v; A.17.a.l5.i; A.17.a.l5.v; A.17.a.l8.i ; A.17.a.l8.v; A.17.a.25.i; 5 A.17.a.25.v; A.17.e.4.i; A.17.e.4. v; A.17.e.6.i; A.17.e.6, v; A.17.e.ll.i; A.17.e.ll.v; A.17.e.l4. i; A.17.e.l4.v; A.17.e.l5.i; A.17.e.l5.v; A.17.e.l8.i; A.17.e.l8. v; A.17.e.25.i; A.17.e.25.v; A.17.g.4.i; A.17.g.4.v; A.17.g.6. i; A.17.g.6.v; A.17.g.ll.i; A.17.g.ll.v; A.17.g.l4.i; A.17.g.l4. v; A.17.g.l5.i; A.17.g.l5.v; A.17.g.l8.i; A.17.g.l8.v; A.17.g.25. i; A.17.g.25.v; Α.17.1.4.Ϊ; A.17.1.4.V; Α.17.1.6.Ϊ; A.17.1.6.V; 10 Α.17.1.11 .Ϊ; A.17.U1.V; A.17.1.14.i; A.17.1.14.V; Α.17.1.15.Ϊ; A.17.I.15.V; Α.17.1.18 .Ϊ; A.17.I.18.V; Α.17.1.25.Ϊ; A.17.1.25.V; A.17.m.4.i; A.17.m.4.v; A .17.m.6.i; A, 17.m.6.v; A.17.m.ll.i ; A.17.m.ll.v; A.17.m.l4.i; A.17.m.l4.v; A.17.m.l5.i; A.17.m.l5.v ; A.17.m.l8.i; A.l7.m.l8.v; A.17.m.25.i; A.17.m.25.v; A.17.o.4.i ; A.17.o.4.v; A.17.o.6, i; A.l7.o.6.v; A.17.o.ll.i; A.17.oUv; A.17 .o.l4.i; 15 A.17.o.l4.v; A.17.o.l5.i; A.17.0.15.V; A.17.o.l8.i; A.17. o.l8.v; A.17.o.25.i; A.17.o.25.v; A.33.a.4.i; A.33.a.4.v; A.33. a.6.i; A.33.a.6.v; A.33.a.ll.i; A.33.a.ll.v; A.33.a.l4.i; A.33. a.l4.v; A.33.a.l5.i; A.33.a.l5.v; A.33.a.l8.i; A.33.a.l8.v; A.33. a.25.i; A.33.a.25.v; A.33.e.4.i; A.33.e.4.v; A.33.e.6.i; A.33. e.6.v; A.33.e.ll.i; A.33.e.ll.v; A.33.e.l4.i; A.33.e.l4.v; A.33. e.l5.i; A.33.e.l5.v; A.33.e.l8.i; 20 A.33.e.l8.v; A.33.e.25.i; A.33 .e.25.v; A, 33.g.4.i; A.33.g.4.v; A.33.g.6.i; A.33.g.6.v; A.33 .g.ll.i; A.33.g.ll.v; A.33.g.l4.i; A.33.g.l4.v; A.33.g.l5.i; A.33 .g.l5.v; A.33.g.l8.i; A.33.g.l8.v; A.33.g.25.i; A.33.g.25.v; Α.33.1 .4.Ϊ; A.33.1.4.V; A.33.1.6.i; A.33.1.6.V; Α.33.1.11.Ϊ; A.33.1.11.V; Α.33.1.14 .Ϊ; A.33.1.14.V; A.33.1.15.i; A.33.1.15.V; A.33.1.18.i; A.3 3.1.18.V; A.33.1.25.i; A.33.1.25.V; A.33.m.4.i; A.33.m.4.v; 25 A.33.m.6 .i; A.33.m.6.v; A.33.m.ll.i; A.33.m.ll.v; A.33.m.l4.i; A.33.m.l4 .v; A.33.m.l5.i; A.33.m.l5.v; A.33.m.l8.i; A.33.m.l8.v; A.33.m.25 .i; A.33.m.25.v; A.33.o, 4.i; A.33.o.4.v; A.33.o.6.i; A.33.o.6 .v; A.33.o.ll.i; A.33.o.ll.v; A.33.o.l4.i; A.33.0.14.V; A.33.o.l5.i ; A.33.o.l5.v; A.33.o.l8.i; A.33.0.18.V; A.33.o.25.i; A.33.o.25.v; A .49.a.4, i; A.49.a.4.v; A.49.a.6.i; A.49.a.6.v; A.49.a.ll.i; A .49.a.ll.v; 30 A.49.a.l4.i; A.49.a.14.v; A.49.a, 15.i; A.49.a.l5.v; A.49.a.l8.i; A.49.a.l8.v; A.49.a.25.i; A.49.a.25.v; A.49.e.4.i; A.49.e.4, v; A.49.e.6.i; A.49.e.6.v; A.49.e.ll.i; A.49.e.ll.v; A.49.e.l4.i; A.49.e.l4.v; A.49.e.l5.i; A.49.e.l5.v; A.49.e.l8.i; A.49.e, 18.v; A.49.e.25.i; A.49.e.25.v; A.49.g.4.i; A.49.g.4.v; A.49.g.6.i; A.49.g.6.v; A.49.g.ll.i; A.49.g.ll.v; A.49.g, 14.i; A.49.g.l4.v; A.49.g.l5.i; A.49, g.l5.v; 35 A.49.g.l8.i; A.49.g.l8.v ; A.49.g.25.i; A.49.g.25.v; Α.49.1.4Λ; A.49.1.4.V; A.49.1.6.i; A.49.1.6.V ; A.49.1.11.i; A.49.1.11.V; Α.49.1.14.Ϊ; A.49.U4.V; A.49.1.15.i; A.49.1.15.V; Α .49.1.18Λ; A.49.1.18.V; Α.49.1.25Λ; A.49.1.25.V; A.49.m.4.i; A.49.m.4.v; A.49 , m.6.i; A.49.m.6.v; A.49.m.ll.i; A.49.m.ll.v; A.49.m.l4.i; A.49 .m.l4.v; A.49.m, 15.i; A.49.m.l5.v; A.49.m.l8.i; A.49.m.l8.v; A.49 .m.25.i; A.49.m.25.v; 40 A.49.0.4.Ϊ; A.49.0.4.V; A.49.o.6.i; A.49.〇. 6.v; A.49.o.ll.i; A.49.o.ll.v; A.49.o.l4.i; A.49.o.l4.v; A.49.〇. 15.i; A.49.o.l5.v; A.49.o.l8.i; A.49.o.l8.v; A.49.o.25.i; A. 49.o. 25.v; B.17.a.4.i; B.l7.a.4.v; B.17.a.6.i; B.17.a.6.v; B.17.a. ll.i; B.17.a.ll.v; B. 17.a.l4.i; B.17.a.l4.v; B.17.a.l5.i; B.17.a. l5.v; B.17.a.l8.i; B, 17.a.l8.v; ΒΛ7.λ.25.ϊ; B.17.a.25.v; B.17.e. 4. i; B.17.e.4.v; B.17.e.6.i; B.17.e.6.v; B.17.e.ll.i; B.17.e.ll. v; 45 B.l7.e.l4.i; B.17.e.l4.v; B.17.e.l5.i; B.17.e, 15.v; 8.17.e, 18.i ; B.17.e.l8.v; B.17.e.25.i; B.17.e.25.v; B.17.g.4.i; B.17.g.4.v ; B.17.g.6.i; B.17.g.6.v; B.17.g.ll.i; B.17.g.ll.v; B.17.g.l4.i ; B.17.g.l4.v; B.17.g .l5.i; B.17.g.l5.v; B.17.g.l8.i; B.17.g.l8.v; B.17.g.25.i; B.17.g .25.v; Β.17.1.4.Ϊ; B.17.1.4.V; B.17.1.6.i; B.17.1.6.V; B.17.1.1U; B.17.1.11.V Please read the back note first

(I-sheet binding) f This paper size applies the Chinese National Standard (CNS) 刎 Specifications (21〇. ≪ 2 叩 mm) -129-4 2 6 6 6 3 A7 4 B7 V. Description of the invention (127) Β. 17.1.14.Ϊ; B.17.1.14.V; B.17.1.15.i; B.17.U5.V; B.17.1.18.i; B.17.I.18.V; Β. 17.Ι.25.Ϊ; ΒΛ7 丄 25 · ν; Β.17 · ιη · 6 * ν; Β17, π \ · 11 · ί; B.17.m.ll-V; B.17.m .l4.i; B.17.m, 14-v; B.17.m.l5.i; B.17.m.l5.v; B.17 * m, 18j; Β, 17 · ιη · 18 -ν; B.17.m.25.i; B.17.m.25-v; TB.17.oAi; Β.17.ο.4 · ν; ΒΛ7.〇.6 · ί; Β.17 Ο + 6 · ν; 5 B.17.o.lli; B.17.o.ll.v; B.17 * o.l4.i; B.17.o.l4.v; B.17. o.l5.i; B.17.o.l5.v; B.17.o.l8-i; B.17.o.l8.v; B.17.o.25.i; B.17. o.25.v; B.33.a.4.i; B.33.a.4.v; B.33.a.6.i; B33.a, 6.v; B.33 * a. ll.i; B.33.a.ll.v; B, 33.a.l4.i; B.33.a.l4.v; B.33.a, 15 * i; B33.a, 15. v; B.33.aJ8.i; B.33.a.l8.v; B.33, a.25.i; B.33.a.25.v; B.33.e.4.i; B.33.eAv; B.33.e.6, i; B.33.e.6 * v; B.33.e.ll.i; B33, e-ll.v; B.33.e. l4.i; B.33.e.l4.v; B.33.e.l5.i; B.33.e-15.v; 10 B33, e.l8.i; B.33.e.l8 .v; B.33.e.25.i; B.33.e.25.v; B33.g.4.i; B.33.g.4 .v; B33, g.6.i; B.33, g.6.v; B.33.g.ll.i; B33.g.ll.v; B.33.g.l4.i; B .33.g.l4.v; B.33.g.l5.i; B.33.g.l5.v; B-33.g.l8.i; B.33.g.l8.v; B .33.g.25, i; B-33.g.25.v; B * 33.L4i; Β.33 · 1Αν; B.33 丄 6i; B.33 丄 6.v; B.33 丄 ll .i; B.33 丄 lhv; B.33 丄 14.i; B.33 丄 14.v; Β33 丄 15 ^ Β · 33 丄 15-v; B.33.L18.i; B.33.1 .18.V; B.33.L25 * i; B.33.L25.V; B.33 * m.4a; B.33.m.4.v; B.33.m.6.i; 15 B.33.m.6 * v; B.33, m.ll.i; B.33.m.ll.v; B33-m.l4.i; B.33.m.l4.v; B. 33.m, 15.i; B.33.m * 15.v; B, 33.m.l8.i; B.33.m.l8.v; B.33.m.25.i; B. 33 * m.25, v; B.33.o.4.i; B.33 * o.4.v; B.33.o.6.i; B.33.o.6.v; B. 33.o.ll.i; B.33.o.ll.v; B.33.o.l4.i; B, 33.o, 14.v; B.33.o.l5.i; B. 33.o.l5.v; B33.o.l8.i; B.33.o.l8.v; B, 33.o.25.i; B.33.o.25, v; B.49. a.4.i; B, 49.a * 4.v; B * 49.a.6.i; B.49.a + 6.v; B.49.a.lli; B.49.a. ll.v; B.49.a.l4.i; B.49, a.l4.v; 20 B.49, a.l5, i; B.49, a.l5 * v; B, 49.a .l8.i; B.49.a.l8.v; B * 49.a.25 * i; B.49.a * 25 * v; B.49.e * 4.i; B.49.e * 4.v; B.49 * e.6.i; B.49.e.6.v; B.49.e, ll.i; B.49, e * ll.v; B.49.e .l4.i; B.49.e.l4.v; B.49.e.l5.i; B.49.e.l5, v; B.49.e.l8i; B.49.e, 18.v; B.49-e.25.i; B * 49.e.25.v; B.49, g.4.i; B.49, g, 4.v; ΒΛ9, $. 6λ; B, 49.g * 6.v; B.49.g.ll-i; B.49.g.ll.v; B, 49. g.l4.i; B.49.g * 14.v; B.49.g.l5.i; B.49, g.l5.v; B.49.g, 18.i; B.49. g.l8, v; B.49.g.25.i; B.49.g.25.v; B.49.L4.i; 25 B_49.1.4_v; B, 49 丄 6.i; B. 49.1.6.V; Β49 丄 1U; B.49, m_v; Β · 49 丄 14 · ί; Β.49.Ι · 14.ν; B, 49.1, l5.i; B.49 丄 15 · ν; Β.49 · Π8.ί; B, 49 丄 18 · ν; Β49.1.25.v; B_49.1.25 + v; B.49.mAi; B.49, m.4.v; B- 49.m.6.i; B.49.m.6 >v; B.49, m.ll.i; B.49.m.ll.v; B.49.m.l4.i; B. 49.m.l4.v; B.49.m.l5j; B.49.m, 15.v; B.49.m-18.i; B.49.m.l8, v; B.49. m, 25.i; Β49.Γη · 25 · ν; Β49.ο, 4.ί; Β.49.ο.4 · ν; B.49.o.6.i; Β49. ο · 6.ν; Β.49 * ο · 11 · ί; Β * 49, οΛ1 · ν; 30 Β · 49 · ο.14 · ί; Β · 49.ο · 14.ν; Β.49.ο .15 · ί; Β49-〇 · 15.ν; Β49_ο · 18.ί; Β49, ο.18.ν; B.49.o, 25.i; B.49.0.25.V ; E.17, a.4.i; E.17.a.4.v; E.17 + a.6.i; E.17.a.6.v; E, 17.a.ll.i ; E.17.a, lLv; E.17.a.l4.i; E, 17.a.l4, v; E.17.a.l5.i; E17, a.l5.v; E.l7 .a.l8.i; E.17.al 8.v; E.17.a.25, i; E.17.a.25.v; E.17.eAi; E.17.e.4.v; E.17.e.6.i; E.17.e.6.v; E.17, e.ll.i; E.17.e.ll.v; E.17.e.l4.i; E.17.e.l4 * v; E.17.e.l5i; E.17.e.l5.v; E.17, e.l8.i; E.17.el8.v; 35 E.17.e.25.i; E17.e .25.v; E.17.g.4i; E.17.g-4.v; E17.g.6.i; E * 17.g.6.v; E.17.g.lU; E .17.gll.v; E.17.g.l4.i; E.17.g.l4.v; E.17.g.l5.i; E.17.g.l5.v; E.17 .g, 18.i; E.17, g, 18.v; E17.g.25.i; E.17.g.25.v; E.17.L4, i; E.1714.V; E .17.L6.1; E.17.I.6.V; E.17.1.11Λ; E17 丄 ll.v; E, 17.1.14i; E.17.1.14.V; E17.L15.i; EJ7115 .v; E.17 丄 18, i; E.17 丄 18.v; E.17 丄 25 · ί; E.17 丄 25.v; E, 17.m * 4.i; ΕΛ7 · πι.4 .ν; E.17 \ mAi; Ε · 17 · ιη.6 · ν; E.17'ni.ll, i; 40 E.17.m, lLv; E.17.m.l4.i; E. 17.m.l4.v; E.17.m.l5i; E.17.m.l5.v; E, 17.m.l8, i; Ε, 17 · Γη · 18 · ν; Ε · 17 ^ π · 25 · ί; Ε · 17 · ιη-25 · ν; Ε · 17 · ο · 4.ί; Ε · 17, ο.4 · ν; E.17.0,6 ″; Ε.17 · ο.6 · Ν; E.17.o, ll.i; Ε.17, ο.11.ν; E.17.o, 14.i; E * 17o.14.v; ΕΛ7.ο, 15.ί; ΕΛ7 .οΛ5.ν; E.17, o, lS.i; Ε.17.οΛ8, ν; Ε.17.0.25.1; Ε.17.ο.25 * ν; E.33.a.4.i; E .33 .a.4.v; E33.a.6.i; E.33.a.6.v; E33-a.ll.i; E.33.a.Xl.v; E.33.a.l4 .i; E.33.a * 14.v; E33.a.l5, i; E, 33.a.l5.v; E.33.al8.i; 45 E.33.a.l8, v; E.33.a_25.i; E.33.a.25 * v; E, 33.e, 4.i; E * 33.e.4.v; E33.e * 6.i; E.33. e.6.v; E.33.e.ll.i; E.33.e.ll.v; E.33.e.l4.i; E.33_e.l4.v; E.33.e. l5.i; E.33.e.l5, v; E.33.e.l8, i; E.33.e.l8.v; E * 33.e.25.i; E.33.e. 25.v; E.33.g.4.i; E.33.g.4.v; E.33.g.6.i; E.33.g.6.v; E33.g.ll. i; E.33.g.ll.v; E, 33.g.l4.i; E.33.g.l4.v; H.33.g.l5.i; E.33.g.l5. v; E-33.g.l8.i; This paper is standard; China Valves Standard (CNS), \ 4 叱! & (Public model) Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs. $ !. 4 2 666 3 ^ A7 _B7___ V. Description of the invention (128) E.33.g.l8.v; E.33.g.25.i; E.33.g.25.v; Ε.33.1.4. Ϊ; E.33.1.4.V; Ε.33.1.6.Ϊ; E.33.1.6.V; Ε.33.1.11 · ί; E.33 丄 ΙΙ, ν; Ε · 33 丄 14.i; E.33.1.14.V; E.33.1.15.i; E.33 丄 15.v; E.33.1.18.i; E.33 丄 18 · ν; E.33 丄 25.i; E. 33 丄 25.v; E.33.m.4.i; E.33.m.4.v; Ε.33 · ιη · 6.ί; E.33.m.6.v; E.33. m.ll.i; E.33.m.ll.v; E.33.m.l4.i; E.33.m.l4.v; E.33. m.l5.i; E.33.m.l5.v; 5 E.33.m.l8.i; E.33.m.l8.v; E.33.m.25.i; E.33 .m.25.v; E.33.o.4.i; E.33.o.4.v; E.33.o.6.i; E.33.0.6.V; E.33.〇 .ll.i; E.33.o.ll.v; E.33.o.l4.i; E.33.o.l4.v; E.33.o.l5.i; E.33.o .l5.v; E.33.o.l8.i; E.33.o.l8.v; E.33.o.25.i; E.33.0.25.V; E.49.a.4 .i; E.49.a.4.v; E.49.a.6.i; E.49.a.6.v; E.49.a, ll.i; E.49.a.ll .v; E.49.a.l4.i; E.49.a.l4.v; E.49.a.l5.i; E.49.a.l5.v; E.49.a.l8 .i; E.49.a.l8.v; E.49.a.25.i; E.49.a.25.v; E.49.e.4.i; E.49.e.4 .v; E.49.e.6.i; 10 E.49.e.6.v; E.49.e.ll.i; E.49.e.ll.v; E.49.e. l4.i; E.49.e.l4.v; E.49.e.l5.i; E.49.e.l5.v; E.49, e.l8.i; E.49.e. l8.v; E.49.e.25.i; E.49.e.25.v; E.49.g * 4.i; E.49.g.4.v; E.49.g. 6.i; E.49.g.6.v; E.49.g.ll.i; E.49.g.ll.v; E.49.g.l4.i; E.49.g. l4.v; E.49.g.l5.i; E.49.g.l5.v; E.49.g.l8j; E.49.g, 18.v; E.49.g.25. i; E.49.g.25.v; E.49.1Ai; E.49.I.4.V; E.49 丄 6.i; E.49.1.6.V; E.49 丄 ll.i ; E.49 丄 ll.v; E_49 丄 14.i; E.49 丄 14.v; E.49.1.15.i; E.49 丄 15.v; 15 E.49 丄 18.i; Ε. 49 · 1 · 18.ν; E.49 丄 E.49 丄 25.v; E.49.m.4.i, E.49.m.4.v; E.49.m.6.i; E.49.m.6.v; E.49.m.ll.i; E.49.m.ll.v ; E.49.m.l4.i; E.49.m.l4.v; E.49.m.l5.i; E.49.m.l5.v; E.49, m.l8.i ; E.49.m.l8.v; E.49.m.25.i; E.49.m.25.v; E.49.o.4.i; E.49.o.4.v ; E, 49.o.6.i; E.49.〇.6.v; E.49.o.ll.i; E.49.o.ll.v; E.49.o.l4.i E.49.0.14.V; E.49.0.15.1; E.49.0.15.V; E.49.o.l8.i; E.49.〇.18.v; E.49.o.25 .i; E.49.o.25.v; H.17.a.4.i; 20 H.17.a.4.v; H.17.a.6.i; H.17.a. 6.v; H.17.a.ll.i; H.17.a.ll.v; H.17.a; 14.i; H.17.a.l4.v; H.17.a. l5.i; H.17.a.l5.v; H.17.a.l8.i; H.17.a.l8.v; H.17.a.25.i; H.17.a. 25.v; H.17.e.4.i; H.17.e.4.v; H.17.e.6.i; H.17.e.6.v; H.17.e. ll.i; H.17.e.ll.v; H.17.e.l4.i; H.17.e.l4.v; H.17.e.l5.i; H.17.e. l5.v; H.17.e.l8.i; H.17.e.l8.v; H.17.e.25.i; H.17.e.25.v; H.17.g. 4.i; H.17.g.4.v; H.17.g.6i; H.17.g.6.v; H.17.g.XX.i; H.17.g.ll. v; 25 H.17.g.l4.i; H.17.g.l4.v; H.17.g.l5.i; H.17.g.15.v; H.17.g.l8 .i; H.17.g.l8.v; H.17.g.25.i; H.17.g.25.v; H.17.1.4.X; H.17.1.4.V; Η .17.1.6.Ϊ; H.17.1.6.V; Η.17.Ι.Π.Ϊ; H.17.1.11.V; H.17.1.14 .i; H.17.I.14.V; H.17.1.15.i; H.17.1.15.V; Η.17.1.18.Ϊ; H.17.1.18.V; Η.17.1.25 .Ϊ; H.17.1.25.V; H.17.m.4.i; H.17.m.4.v; H.17.m.6.v; H.17.m, ll.v ; H.17.m.l4.i; H.17.m.l4.v; H.17.m.l5.i; H.17.m.l5.v; 30 H.17.m.l8. i; H.17.m.l8.v; H.17.m.25.i; H.17.m.25.v; H.17.〇.4.i; H.17.o. 4. v; H.17.o.6.i; H.17.0.6.V; H.17.〇.ll.i; H.17.o.ll.v; H.17.o.l4.i; H.17.o.l4.v; Η.17.0.15.Ϊ; H.17.o.l5.v; Η.17.0.18Λ; H.17.o.l8.v; H.17.o. 25.i; H.17.o.25.v; H.33.a.4.i; H.33.a.4.v; H.33.a.6.i; H.33.a. 6.v; H.33.a.ll.i; H.33.a.ll.v; H.33.a.l4.i; H.33.a.l4.v; H.33.a. l5.i; H.33.a.l5.v; H.33.a.l8.i; H.33.a.l8.v; H.33.a.25.i; 35 H.33.a .25.v; H.33.e.4.i; H.33.e.4.v; H.33.e.6.i; H.33.e.6.v; H.33.e .ll.i; H.33.e.ll.v; H.33.e.l4.i; H.33.e.l4.v; H.33.e.l5.i; H.33.e .l5.v; H.33.e.l8.i; H.33.e.l8.v; H.33.e.25.i; H.33.e.25.v; H.33.g .4.i; H.33.g.4.v; H.33.g.6.i; H.33.g.6.v; H.33.g.ll.i; H.33.g .ll.v; H.33.g.l4.i; H.33.g.l4.v; H.33.g.l5.i; H.33.g.l5.v; H.33.g .l8.i; H.33.g.l8.v; H.33.g.25.i; H.33.g.25.v; .33.1.4.Ϊ; H.33.1.4.V; Η.33.1.6.Ϊ; H.33.L6.V; 40 H.33 丄: Ll.i; H.33.1.11.V; H .33.1.14.i; H.33.U4.V; Η.33.1 · 15 · ί; Η.33.1 · 15 · ν; H.33 丄 18.i; H.33, i.l8.v; Η 33 丄 25.i; Η.33 · 1.25 · ν; H-33.m.4.i; H.33.m.4.v; H.33.m.6.i; H.33.m .6.v; H.33.in.ll.i; H.33.m.ll.v; H.33.m.l4.i; H.33.m.l4.v; H.33.m .l5.i; H.33.m.l5.v; H.33.m.i8.i; H.33.m.l8.v; H.33.m.25.i; H.33.m .25.v; H.33.o.4.i; H.33.0.4.V; Η.33.0.6.Ϊ; H.33.〇.6.v; H.33.o.ll.i H.33.〇.ll.v; H.33.o.l4.i; 45 H.33.o.l4.v; H.33.o.l5.i; H.33.o.l5. v; H.33.o.l8.i; H.33.o.l8.v; H.33.o.25.i; H.33.0.25.V; H.49.a.4.i; H.49.a.4.v; H.49.a.6.i; H.49.a.6.v; H.49.a.ll.i; H.49.a.ll.v; H.49.a.l4.i; H.49.a.l4.v; H.49.a.l5.i; H.49.a.l5.v; H.49.a.l8.i; H.49.a.l8.v; H.49.a.25.i; H.49.a.25.v; H.49.e.4.i; H.49.e.4.v; H.49.e.6.i; H.49.e.6.v; H.49.e.ll.i; Please read the precautions before reading

Ding Gongsi) 131 42666 3, at B7 V. Invention Description (129) 5 10 15 20 25 35 Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs 45 H.49.e.ll.v; H.49.e, 14.i; H.49.eJ4.v; H.49, e.l5.i; H.49.e.l5.v; H.49.e-18.i; H.49.e, 18. v; H.49.e.25.i; H.49.e.25.v; H.49.g.4.i; H.49.g.4.v; H.49.g.6. i; H.49.g, 6.v; H.49.g.ll.i; H.49.g.ll.v; H.49.g, 14.i; H.49.g.l4. v; H.49.g.l5, i; H.49.g.l5.v; H.49.g.l8.i; H.49.g.lS.v; HA9.g25A; H.49. g.25.v; H.49.1.4.i; R49.L4.V; H.49.L6.i; H.49 丄 6.v; H.49.UU; Η · 49.1 · 11.ν; H.49.L14.i; R49 丄 14.v; Η · 49 · 1 · 15 · ί; Η, 49 · Ι · 15 · ν; H.49118.1; H, 49.1.18.v; H.49.1. 25, i; H.49.1.25.V; H.49.m.4.i; H.49.m.4.v; H.49, m.6.i; H-49.m.6. v; H.49.m.ll.i; H.49.m4ll.v; H.49.m, 14, i; H.49.m * 14.v; H, 49.m.l5J; H. 49, m.l5.v; H.49.m-18.i; H.49.m.l8-V; H, 49.m.25.i; H, 49 * m.25.v; H. 49.0.4.1; H.49.o.4, v; H.49.o.6.i; H.49, o.6.v; H.49.oJl.i; H.49.o.ll. v; H.49.ol4.i; Η.49.ο.14.ν; H.49.〇.15i; H.49.o.l5, v; H.49.o.l8.i; H, 49.o.l8.v; H, 49.o.25i; HA9r〇.25.v; L17.a, 4.i; L17.a.4.v; L1 7.a.6 * i; L17.a, 6.v; L17.a.lli; L17, a.ll.v; L17.a.l4.i; I.17, a, 14.v; L17. a.l5.i; L17, a.l5 * v; I.17.a, 18.i; I.17.a.l8.v; L17, a.25i; Ι, 17 ^ .25.ν; L17 .e * 4.i; L17.e.4.v; I.17.e.6i; L17.e.6.v; I.17.e.lli; L17.e.ll.v; Ll7, el4i ; L17, e, 14 * v; I.17.e.l5.i; I.17.e.l5, v; I.17.βΛ8Λ; Ll7.e.l8.v; L17.e * 25.i ; I. 17.e.25.v; L17 * g * 4.i; L17, g.4.v; L17.g.6.i; L17.g.6.v; L17.g.lli; L17 .g, ll.v; Ι17 ^ 14.ί; L17.g.l4, v; L17, g.l5i; I.17.g.l5.v; I.17.g.l8, i; L17.g .l8.v; L17.g.25.i; 1.17. g.25.v; 1.17 · 1 · 4Λ; 1.17 丄 4v; U7 丄 6.i; I, 17.L6_v; U7 丄 Hi; Ι · 17 · 1,11 · ν; 1.17 丄 14 ″; L17.1.14.V; I.17.L15.i; L17.1.15.V; L17.L18.i; I.17.1.18.V; L17. I.25.i; I.17.L25.V; L17.m.4.i; L17.m.4, v; L17.m.6i; L17.m.6.v; L17.m.ll. i; L17.m.ll.v; L17.jn.l4.i; 1.17. m.l4.v; I.17.m.l5.i; I.17, m.l5.v; L17.m. l8.i; I.17.m.l8.v; I.17.m.25i; L17, m, 25.v; I.17.o.4.i; I.17.o.4.v; I.17.o.6.i; I.17.o.6.v; L17.o.ll.i; I.17.o.ll, v; Ι · 17 · οΛ4.ί; I.17. o.l4.v; L17.o.l5.i; Ι.17 · ο · 15.ν; L17.o.l8.i; Ι · 17 · ο , 18_ν; L17.o.25-i; Ι17.ο * 25.ν; I.33.a.4, i; I.33-a.4, v; L33.a.6.i; L33-a .6, v; I.33.a.ll.i; I.33.a.ll.v; 1.33. A.l4.i; L33.a.l4.v; 1.33.3.15.1; L33.a .l5.v; I.33.a, 18.I; L33.a, 18.v; L33.a.25.i; 1.33. a.25.v; I.33 * eAi; I.33.eAv ; I_33.e.6.i; L33, e-6.v; I.33, e.ll.i; I.33 * e.ll.v; 1.33. E.l4a; I.33.e.l4 .v; I.33.e.l5.i; 1.33, e.15-v; L33.eJ8.i; L33.e.l8, v; L33.e.25.i; 1.33. e.25.v ; L33.g.4J; L33.g, 4.v; I.33.g-6, i; L33, g.6.v; I.33 * g.ll.i; L33.g.lLv; L33 .g, 14.i; L33.g.l4, v; L33.g * 15.i; I.33.g * 15.v; I.33.g-18i; I.33.g.l8.v ; L33, g-25.i; L33.g.25, v; L33JA1; L33J, 4.v; I.33J, 6.i; L33.I.6, v; I.33.1.11.i; L33 .1.11, v; L33UU; Ι3.3 · 1 · 14.ν; 1.33 丄 15.i; I_33 丄 15_v; 1,33 丄 18 ″; Ι_33 · Ι · 18 · ν; 1.33125.i; L33.L25. v; L33, m, 4.i; I.33.m.4.v; L33.m, 6.i; L33 * m.6.v; 1.33.m.11.i; L33.m.ll. v; I.33, m.l4.i; L33.m-14.v; L33.m.l5.i; 1.33, m.l5, v; L33.m.l8.i; I, 33, m. l8.v; L33, m.25.i; 1.33. m.25.v; L33.o.4.i; L33.o.4, v; L33.o.6.i; L33.0.6.V; 1.33.0, 11.i; Ι.33.οΛ1.ν; L33.o.l4.i; I.33 * o.14.v; L33 .o.l5i; I.33.o.l5.v; I.33.〇.18.i; I.33.o.18.v; 1.33.0.25.i; I.33.0.25.V; I .49.a.4.i; L49.a.4.v; I.49.a.6.i; L49.a.6.v; I.49.a.ll.i; I.49.a .ll.v; 1.49. a.l4.i; I.49.a.l4.v; L49.a, 15.i; I.49_a.l5.v; L49.a.l8.i; L49.a .l8.v; I.49, a.25.i; 1.49.a, 25.v; I.49.e.4.i; I.49.e.4.v; L49.e.6i; L49 .e.6, v; I.49.e.lLi; I.49.e.ll.v; L49.e.l4.i; L49.e.l4.v; L49.e, 15.i; L49 .e.l5.v; I.49.e.l8.i; L49.e.l8.v; L49.e.25.i; 1.49. e.25.v; ΙΛ9, ξΑλ; I.49.g .4.v; I.49.g.6.i; L49, g.6.v; L49.glU; L49.g.ll, v; 1.49. G.l4.i; L49.g.l4.v ; I.49, g.l5.i; L49.g.l5, v; L49.g.lS, i; L49, g.l8.v; L49.g, 25.i; 1.49.g.25.v ; L49.L4.i; I.49.L4.V; I.49.1.6, i; L49.L6.V; I, 49.1.1Li; I.49.L11.V; L49114.i; I.49.1 .14.V; I.49a.l5.i; I.49.1.15.V; L49.1.18.i; I.49118.V; L49.1.25.1; I.49.1.25.V; 1.49. M .4.i; I.49.m.4v; I.49, m.6, i; L49.m * 6.v; I.49.m.ll.i; I.49.m.ll.v ; 1,49.m.14.i; Ι * 49.γπ.14λ ·; L49.m.l5.i; 1.49.m.15.v; I.49.m.l8.i; L49.m. l8.v; I.49, m.25.i; 1.49. m.25.v; 1.49, o.4, i; Ι, 49 · ο_4 · ν; Ι · 49, ο.6.i; 1,49.0.6.v; Ι49 · 〇 · Π_ί; Ι49 · ο.Π.ν; L49, o, 14.i; 1.49.0,14.v; 1.49.o.l5.i; L494〇, 15.v; L49.〇.lS-i; L49, o.l8.v; L49.〇.25.i; L49.o.25.v; L.17 .a.4.i; L.17.a.4.v; L.l7.a.6a; L.17.a.6.v; L.17.a.lLi; L.17.a.ll .v; L.17.a.l4.i; L.17.a.l4.v; L.17.a.l5.i; L.17.a.l5.v; L.17, a.lS -i; L.17.a.l8.v; L.17.a * 25a; please read% 6 note

I The size of the paper is appropriate. Use (National Standard Chinese Standard (CNS) Λ4 specifications · (moment) -132-A7 B7 426663 V. Description of the invention (i3G) L, 17.a.25, v; L.17 .e.4.i; L.17, e.4.v; L, 17.e.6.i; L, 17.e.6, v; L.17, e.ll.i; L * 17 .e.ll.v; L.17.e.l4.i; L.17.e.l4.v; Lfc17, e.l5.i; L.17.e.l5.v; L.17.e .l8.i; L.17.e.l8.v; L, 17.e.25.i; L.17.e.25.v; L.17.gAi; L, 17.gAv; L.17 .g.6.i; L.17.g, 6.v; L.17.g.ll, i; L.17.gll.v; L.17.g.l4i; L.17.g.l4 .v; L.l7.g.l5.i; L.17.g.l5.v; LA7.gA8A; L.17.g.l8.v; L.17.g.25.i; 5 L. 17.g.25.v; L.17.L4J; L.17.I.4.V; L.17.L6.1; L.17.1.6.V; L, 17.Lll.i; L. 17.L11.V; L17.I.14i; L.17114.V; L.17.U5.i; L.17.U5.V; L.17118.i; L.17.1.18.V; ^ 17.125 .1; L, 17 丄 25 · ν; TL17jriji.i; L * 17.mAv; L.17-m.6.i; L.17-m-6.v; L.17.m.lLv; L , 17.m.l4.i; L.17.m.l4.v; L.17, m.l5.i; L.17, m.l5.v; L.17.m.l8J; L.l7 .m.l8.v; L.17.m.25.i; L.17, m.25.v; L.17, o.4.i; L.17.o.4.v; L.17 .o, 6.i; L17.o.6.v; 10 L.17-〇.ll.i; L.17.o, ll.v; L.17.o.l4.i; L.17. 〇.14.v; L.17.o.l5.i; L.17.o.l5 * v; L.17.o.l8.i; L.17.0.18.V; L.1 7.o.25.i; LJ7.0.25.V; L.33.a.4.i; L.33.a.4.v; L.33.a.6.i; L.33.a. 6.v; L.33.a.ll, i; L33.a.ll.v; L33.a.l4.i; L.33.a.l4.v; L.33.a.l5.i; L.33.a.l5.v; L.33.a, 18-i; L.33.a.l8.v; L.33.a, 25.i; L.33, a.25, v; L.33.e.4.i; L.33.e.4.v; L.33.e.6i; L.33.e.6.v; 1 ^ .33.6.11 Λ; B, 33. e.ll.v; L, 33.eHi; Ι ^ 33.θ_14, ν; L33.e.l5.i; L.33, e.l5.v / L-33.e.l8 * i, '15 L, 33, e.l8.v; L.33.e.25 j; L.33.e.25.v; L.33.g.4.i; L.33.g.4.v; L .33.g.6.i; L.33.g.6, v; L-33.g.lLi; L.33.g.ll.v; L.33, g.l4.i; L.33 .g.l4.v; L.33.g.l5.i; L33.g.X5.v; L33.gl8-i; L.33.g, 18.v; L, 33.g.25.i ; L.33-g.25, v; L.33.1.4.i; L.33,1.4.v; L.33.I, 6.i; L.33.1,6, v; L.33 丄 ll .i; ί.33 · 1 · 11 · ν; L.3: Ul4, i; L.33.1.14.V; L.33115 Mountain L.33 丄 15.v; B · 33 丄 18.i; ί .33.1.18.ν; L.33, L25.i; L.33.I.25.V; L33.m, 4.i; L.33.m.4.v; L, 33.m.6 .i; L.33.m.6, v; 20 L.33, m.ll.x; L.33.m.ll.v; L.33.m.l4.i; L33.m.l4. v; L.33, m.l5.i; L.33.m.l5.v; L.31n \, 18.i; L.33.m.l8.v; L.33, m.25.i ί · 33 · ΓΠ · 25 · ν; L-33-〇.4 * i; B, 33 · ο, 4v; L-33, cx6-i; L. 33.0.6-V; L. 33.o .ll .i; L-33, o.ll.v; L.33.0.14, i; L.33-〇.14.v; L, 33 * o, 15, i; L.33.oJ5.v; L .33, o.l8.i; L.33.o.l8.v; L, 33.o.25.i; L.33.0.25.V; L.49.a.4.i; L.49 .a.4, v; L.49.a.6.i; L49.a, 6.v; L, 49.a.ll.i; L.49.a.ll.v; L.49 * a .l4.i; L.49.a.l4 * v; L.49, a.l5.i; L ^ .a.lS.v; 25 L.49.a.l8i; L, 49.a.l8 .v; L.49.a.25.i; L-49.a.25.v; L-49-eAi; B49.6 · 4, ν; L.49-e.6-i; L49, e .6.v; L.49.e.ll.i; L.49.e.ll.v; L.49.e.l4.i; L, 49.e.l4.v; L.49.e .l5i; L_49.e.l5.v; L.49 ^ e, 18.i; L.49.e, 18.v; L.49.e, 25.i; L.49.e-25.v ; L.49.g.4.i; L.49.g.4.v; L-49.g-6.i; L.49.g.6.v; L.49.g Jli; L. 49.g.ll.v; L, 49.g.l4.i; L-49.g.l4.v; L.49.g.l5.i; L.49.g, 15.v; L49. g.l8, i; L.49.g.l8.v; L.49.g.25, i; L, 49.g, 25.v; L.4914 L, 49 丄 4 · ν; L.49丄 6 * i; 30 L.49.I.6.V; L.49.I, ll.i; L-49-1.ll, v; L.49,1.14-i; L.49.1.14- v; L * 49.1_15.i; L.49 丄 15-v; L.49.1.18.i; 1L49 丄 18.v; B, 49.1.25.i; B. 49 丄 25.v; L.49 .m.4.i; L.49.m.4.v; Ι ^ · 49.ιη.6.ί; L49'm.6.v; L, 49.m.ll.i; 149 · π \ · 11 · ν; 149 · ιπ, 14 · ί; L.49, m.l4'v; L49.m.l5 ″; L.49.m.l5.v; L.4 9.m.l8.i; L.49 * m.l8.v; L.49.m.25i; L.49.m * 25.v; L49.o.4i; L, 49.o.4 * v; L.49, o.6.i; L.49.o, 6.v; L.49.o.lli; L.49.o.ll.v; L.49.o.l4.i; L, 49, o.l4.v; 35 L.49.o.l5.i; L.49.o.l5.v; L.49.o.l8.i; L.49.0.18.V; L .49.o.25.i; L.49.o.25.v; B.93.a.4.i; Printed by the M Industry Consumer Cooperatives of the Ministry of Economic Affairs, China, B.93.a.4 * v; B, 93.a, 6.i; B * 93.a.6.v; B.93.a.ll.i; B.93, a.ll.v; B.93.a.l4. i; B.93.a.l4.v; B.93.a.l5.i; B.93.a.l5.v; B.93.a, 18.i; B.93.a, 18. v; B.93.a.25i; B.93.a.25.v; B.93.e.4i; B53.e.4.v; B.93, e.6i; B.93, e. 6.v; B.93, e.ll, i; B.93, e.ll.v; B.93.e.l4, i; B.93.e * 14.v; B.93.e. l5i; B.93.e.l5.v; B.93.e.l8.i; B.93, e.l8.v; B.93.e.25i; B.93.e, 25.v; B.93 (g.4.i; 40 B, 93.g.4, v; B.93.g.6.i; B, 93-g.6.v; B.93.g.ll.i ; B.93.g.ll.v; B, 93.g.l4.i; B.93, g.l4.v; B.93.g.l5i; B.93.g.l5.v; B .93.g.lS.i; B.93.g.l8.v; B, 93.g.25.i; B.93.g.25.v; B, 93.1.4.i; B.93丄 4ν; B.93.Ui; B.93 丄 6-v; Bi93.1.11.i; B.93 丄 ll.v; B.93.1.14 丄 -B.93.U4.V; B_93 丄15.i; B.93.I, 15.v; B.93, U8.i; B-93.1.1S.V; B.93 丄 25.i; Β · 93 · 1.25.ν; B.93, m.4.i; B, 93.m.4, v; B.93.m.6.i; B.93.m * 6.v; B.93-m.ll.i; B.93.m.ll.v; B.93.m.l4.i; 45 B.93.m.U_v; B.93.m.l5.i; B.93.m.l5.v; B , 93.rrUS.i; Β.93 · π · 18.ν; Β · 93 · γπ, 25 ″; B.93.m.25.v; B.93.oAi; Β.93.ο · 4. ν; Β · 93.ο · 6_ί; Β · 93.ο.6 · ν; B.93, oJl, i; Β.93 · ο.11 · ν; Β · 93 · ο.14_ί; Β.93. α14.ν; Β, 93 · ο · ΐ5 · ί; Β, 93.ο · 15, ν; Β, 93 · ο.18, ί; Β.93.οΛ8 · ν; B.93.o.25i; B.93.o.25, v; Β.94.α.4.ί; B.94.a.4.v; B.94.a.6.i; Bt94.a, 6.v; B, 94.a.ll.i; This paper size is applicable to the Chinese national standard) CCNS) M wash grid (Qiao 丨 mm> 4 266 6 3 Λ V. Description of the invention (131) B.94.a.ll.v; B .94.a.l4.i; B.94.a.l4.v; B.94, a.l5.i; B.94.a.l5, v; B.94.a.l8.i; B .94.aJ84v; B, 94.a.25.i; B.94.a.25.v; B.94.e.4, i; B.94.e.4.v; B, 94.e .6.i; B.94, e, 6, v; B, 94.e.ll.i; B-94.e.ll.v; B.94.e, 14J; B.94.e.l4 , v; B.94.e.l5.i; B.94.e.l5.v; B.94.e.lS.i; B.94.e.l8, v; B.94.e.25 .i; B.94.e.25.v; B.94.g.4.i; B.94.g.4.v; B.94.g.6.i; B.94.g.6 .v; B, 94, g.ll.i; 5 B.94 * g, ll.v; B.94.g.l4.i; B.94.g.l4.v; B.94 , g.l5i; B.94.g.l5.v; B.94, g.l8.i; B.94.g.l8.v; B, 94.g.25.i; B.94.g .25.v; B.94.1.4.i; B.94.1.4.V; B.94.1.6.i; B.94.L6.V; B.94.Lll.i; Β, 94.1.Π Ν; B.94 丄 14.i; Β · 94 丄 14.v ;, B, 94 丄 15.i; Β94.Ι · 15 · ν; Wen 94L18, i; B, 94 丄 18.v Β · 94 丄 25.i; Β · 94 · 1 · 25, ν; Β · 94 · ιη-4.ί; Β · 94 · ϊη.4 · ν; Β · 94 · ηι · 6 · ν; B .94.m.lLi; B.94.m.ll.v; B, 94.mJ4.i; B.94.m.l4, v; B.94.m, 15i; B.94.m.l5 .v; B.94.m.l8.i; 10 B-94.m.l8.v; B.94.m.25.i; B.94.m.25.v; B.94.o. 4.i; B.94.o.4.v; B.94.o.6.i; B.94.o, 6.v; B.94.o, ll.i; B.94.0.11. V; B.94, o.l4.i; Β.94.οΛ4 <ν;B.94.o.l5.i;B.94.〇.15.v; Β · 94 · ο.18, ί; Β * 94.ο · 18-ν; B.94.o.25i; Β · 94 · ο · 25 · ν; E.93.a.4.i; E.93.a.4.v; E, 93, a.6i; E.93.a, 6.v; E.93.a.ll.i; E.93.a.ll * v; E_93.a.l4i; E.93.a.l4. v; E.93.a, 15.i; E.93.a.l5.v; E, 93.a <18.i; E.93.a, 18.v; E.93, a.25. i; E.93.a.25.v; E.93.e.4i; E.93.e-4.v; E.93.e, 6.i; 15 E, 93.e.6-v ; E.93, e.lli; E.93.e.ll.v; E.93.e.l4i; E.93.e.l4.v; E.93.e.l5.i; E.93 .e.l5.v; E.93.e.l8.i; E.93 , e.l8.v; E.93.e.25.i; E.93.e.25_v; E.93 * g.4.i; E.93-g.4, v; E.93.g .6.i; E.93.g.6.v; E.93.g.ll.i; E.93-g.ll.v; E.93.g, 14 j; E.93.g. l4.v; E.93.g.l5.i; E.93, g.l5.v; E.93.g.l8.i; E.93.g.l8.v; E, 93.g. 25, i; E.93.g25.v; E.93.L4i; E.93.1.4.V; E.93.1.6.i; E.93.I.6.V; E.93.1.11. i; E.93.U1.V; E.93.U4.i; E.93 丄 14.v; E.93 丄 15.i; E.93.I.15.V; 20 E.93 丄 Ι8 · Ί; Ε · 93.1 · 18 · ν; E.93 丄 25-i; Ε.93 · 1 · 25 · ν; E.93.m-4.i; Ε-93 · ιη.4.ν; Ε · 93 · ιη · 6 · ί; E.93.m.6, v; E.93.m, lla; E.93.m * ll.v; E.93.m, 14a; E.93.m .l4.v; E.93.m.l5.i; Ε.93.ιη.15.ν; H.93.m.l8.i; E.93, m.l8.v; E.93.m .25.i; E.93.m.25.v; E.93.o, 4.i; E, 93.o.4.v; E.93.o.6.i; E-93, o .6.v; E.93-〇.lLi; E.93.o.ll.v; E.93.o.l4i; E.93.o.l4.v; E, 93.o, 15.i ; E.93.o, 15, v; E.93, o.l8.i; E.93 * o.l8, v; E.93 * o.25, i; E.93-〇.25 * v ; E * 94.a.4.i; 25 E.94.a, 4.v; E.94.a.6.i; E.94.a, 6.v; E.94.a, ll * i; E.94.a.ll.v; E.94.a.l4.i; E.94.a.l4, v; E.94-a, 15.i; E.94.a.l5. v; E * 94.a.l8.i; E * 94.a.l8.v; E.94.a.25.i; E.94.a.25.v; E.94.e. 4. i; E.94.e.4.v; E.94.e. 6.i; E.94.e.6.v; E.94.e.lla; E.94. € .ll.v; E.94.e.l4.i; E.94.e, 14. v; E.94.e.l5.i; E * 94, e.l5.v; E.94.e.l8 * i; E.94.e.l8.v; E.94.e.25. i; E.94.e.25.v; E.94, g.4.i; E, 94.g.4.v; E.94.g.6.i; E.94.g.6, v; E.94.g, ll.i; E.94.g.ll.v; E.94.g, 14.i; E.94.g.l4.v; 30 E.94.g.l5J ; E.94.§.15 · ν; E_94_g, 18.i; Ε.94 · § · 18 · ν; E_94, g.25_i; Ε · 94 · & 25 · ν; E.94 丄 4, i ; E.94 丄 4.v; Ε · 94 丄 6 · ί; E.94 丄 6, v; E, 94 丄 ll.i; Ε · 94 · 1 · 11 · ν; E.94.1.14, i E.94 · I.14.ν; E.94.1.15ΰ; H.94.1.15.V; E.94.I.18 j; E.94.L18.V; E.94.1.25.i; E, 94.L25.v; E.94.m, 4.i; E.94, m.4.v; E.94 * m.6.i; E, 94.m.6.v; E, 94.m.ll.i; E, 94.m.ll.v; E.94.m, 14.i; Ε * 94.ιπ.14λ ?; E, 94.m.l5.I; E.94 .m.l5.v; E.94.m.l8.i; E.94.mJ8.v; E.94.m.25.i; 35 Ε · 94 · Γη.25.ν; Ε.94 · ο · 4_ί; Ε_94 · ο · 4 · ν; Ε · 94 · ο: 6, ί; Ε, 94.ο · 6, ν; E.94, o_llfi; Ε-94 · ο.Π · ν; Ministry of Economic Affairs Printed by E.94, o.l4.i; E.94.0.14.V; Ε.94.〇.15.ΐ; Ε.94.ο.15.ν; H.94 .o.l8.i; Ε.94.ο, 18.ν; E.94.o.25.i ; Ε, 94.ο, 25.ν; I.93.a.4.i; I.93.a.4.v; L93.a.6.i; L93.a.6.v; L93.a , ll.i; I.93.a-ll, v; L93.a.l4.i; I, 93.a.l4.v; I.93.a.l5.i; I.93.a.l5 .v; I.93.a.l8.i; L93.a.l8.v; I.93.a.25.i; L93.a.25, v; I.93.e.4.i; I .93.e.4.v; L93.e.6.i; L93.e.6, v; L93.e.ll.i; I.93.e.ll.v; 40 L93.e.l4, i; L93.e.l4.v; I.93.e.l5.i; L93.e.l5.v; I.93.e.l8.i; L93.e.l8.v; I.93. e.25.i; 1.93. e.25.v; I.93.g * 4.i; I.93.g.4.v; L93.g.6, i; I.93.g.6. v; L93.g.ll.i; L93.g.ll.v; L93.g.l4.i; I.93, gJ4.v; L93.g.l5.i; L93.g.l5.v; I.93.g.l8-i; I.93.g.l8.v; L93.g, 25.i; 1.93.g.25.v; I.93.1Ai; L93.1.4.V; I.93.1 .6.i; I.93.I.6 * v; Ι9311Π; I.93.L11.V; L93.1.14.i; 1.93 丄 14.v; L93 丄 15.i; 1.93 丄 15 · ν ; 1.93 丄 18.i; 1.93 丄; IS.v; 1.93 丄 25.i; L93 丄 25 · ν; 45 I.93-m.4.i; L93.m.4.v; I.93.m .6.i; I.93.m, 6, v; l.93.m.ll.i; L93.m.ll.v; 1.93.m.14.i; L93.m.l4.v; 1.93 .m.15.i; I.93.m.l5.v; I.93.m.lS-i; I, 93.m.l8.v; 1.93.m.25.i; L93.m.25 .v; 1.93, 〇-4.i; L93.o, 4.v; L93.o.6.i; I.93.〇-6.v; L93 * o.ll.i; L93.o.ll .v; L93.o.l4.i; L93.0.14.V 1.93.0.15.i; L93.o.l5.v; 1.93.0.18-i; 1.93.0.18.v; Ι, 93.ο.25ά; This paper size applies Chinese National Standard (CNS) Λ4 specification (21〇 x'297 公 漦) _ 4 2 6 6 6 3 ^ __ B7___ V. Description of the invention (132) 1.93.0. 25.V; I.94.a.4.i; I.94.a.4.v; I.94.a.6.i; I.94.a.6.v; I.94.a.ll.i; I.94.aHv; 1.94. A.l4.i; I.94.a. l4.v; I.94.a.l5.i; I.94.a.l5.v; I.94.a.l8.i; I.94.a.l8.v; I.94.a. 25.i; 1.94. A.25.v; I.94.e.4.i; I.94.e.4.v; I.94.e.6.i; I.94.e.6. v; I.94.e.ll.i; I.94.e.ll.v; 1.94. e.l4.i; I.94.e.l4.v; I.94.e.l5.i; I.94.e.l5.v; I.94.e.l8.i; 1.94.e.18.v; I.94.e.25.i; 5 I.94.e.25.v; I .94.g.4.i; I.94.g.4.v; I.94.g.6.i; I.94.g.6.v; I.94.g.ll.i; I .94.g.ll.v; 1.94. G.l4.i; I.94.g.l4.v; I.94.g.l5.i; I.94.g, 15.v; I.94 .g.l8.i; I.94.g.l8.v; I.94.g.25.i; I_94.g.25.v; 1.94 丄 4.i; 1.94 丄 4.v; 1.94 丄 6 .i; I.9U.6.V; 1,94 丄 ll.i; 1.94 丄 ll.v; 1.94 · 1.14.ί; I.94.1.14.V; 1.94 丄 15.i; 1.94 丄 15 .v; I.94.U8.i; I.94.1.18.V; L94 丄 25.i; 1.94125.V; 1.94. m.4.i; I.94.m.4.v; I.94 .m.6.i; I.94.m.6.v; I.94.m.ll.i; I .94.m.ll.v; I.94.m.l4.i; 10 I.94.m.l4.v; I.94.m.l5.i; I.94 * m.l5.v; I.94.m.l8.i; L94.m.l8.v; I.94.m.25.i; 1.94. M.25.v; 1.94.0.4.i; I.94.o. 4. v; 1.94.0.6.i; 1.94.0.6-v; 1.94.0.11.i; 1.94.0.ll.v; 1.94.0. 14.1. 1.94.0.14.v; I.94.o.l5.i; 1.94.0.15, v; I.94.o.18.ί; Ι.94.ο.18 * ν; 1.94.0.25.:; 1.94.0. 25.v; L.93.a.4.i; L.93.a.4.v; L.93.a.6.i; L.93.a.6.v; L.93.a.ll.i; L.93.a.ll.v; L.93.a, l4.i; B, 93.a.l4.v; L.93.a.l5.i; L.93.a.l5.v; L.93.a.l8, i; L.93.a.l8.v; L.93.a.25.i; 15 L.93.a.25.v; L.93.e.4.i; L.93.e.4.v ; L.93.e.6.i; L.93.e.6.v; L.93.e.ll.i; L.93.e.ll.v; L.93.e.l4.i ; L.93.e.l4.v; L.93.e.l5.i; L.93.e.l5.v; L.93.e.l8.i; L.93.e.l8.v ; L.93.e.25i; L.93.e.25.v; L.93.g.4.i; L.93.g.4.v; L.93.g.6.i; L .93.g.6.v; L.93.g.ll.i; L.93.g.ll.v; L.93.g.l4.i; L.93.g.l4.v; B _93.g.l5.i; L.93.g.l5.v; L.93.g.l8.i; L.93.g.l8.v; L.93.g.25.i; L .93.g.25.v; L.93.1.4.i; L.93.1.4.V; L.93.1.6.i; L.93.1.6.V; L.93.1.11.i; L .93.1.11.V; 20 L, 93114.i; L. 93 丄 14.v; L. 93 丄 15.i; L. 93.1.15.V; L.93 18, i; L.93 丄 18.v; L.93 丄 25.i; L.93.1.25.V; L.93.m.4.i; L.93.m.4.v; L. 93.m.6.i; L.93.m.6.v; L.93.m.ll.i; L.93.m.ll.v; L.93.m.l4.i; L. 93.m.l4.v; L.93.m.l5.i; L.93.m.l5.v; L.93.m.l8.i; L.93.m.l8.v; L. 93.m.25.i; L.93.m.25, v; L.93.o.4.i; L.93.o.4.v; L.93.o.6.i; L. 93.o.6.v; L.93.o.ll.i; L.93.0.11.V; L.93.o.l4.i; L.93.o.14.v; B.93.0. 15 』; L.93.o.l5.v; L.93.o.l8.i; 25 L.93.o.l8.v; L.93.o.25.i; L.93.〇- 25.v; L.94.a.4.i; L.94.a.4.v; L.94.a.6.i; L.94.a.6.v; L.94.a. ll.i; L.94.a.ll.v; L.94.a.l4.i; L.94.a.l4.v; L.94.a.l5.i; L.94.a. l5.v; L.94.a.l8.i; L.94.a.l8.v; L.94.a.25.i; L.94.a.25.v; L.94.e. 4.i; L.94.e.4.v; L.94.e.6.i; L.94.e.6.v; L.94.e.ll.i; L.94.e. ll.v; L.94.e-14.i; L.94.e.l4.v; L.94.e.l5.i; L.94.e.l5.v; L.94.e. l8.i; L.94.e.l8.v; L.94.e.25.i; L.94.e.25.v; L.94.g.4.i; L.94.g. 4.v; L.94.g.6.i; L.94.g.6.v; 30 L.94.g.ll.i; L.94.g.ll.v; L.94.g .l4.i; L.94.g.l4.v; L.94.g.l5.i; L.94.g.l5.v; L.94.g.l8.i; L.94.g .l8.v; L.94.g.25.i; L.94.g.25.v; L.94.1.4.i; L.94.1.4.V; L.94.1 .6.i; L.94.1.6.V; L.94.UU; L.94 丄 ll.v; L.94 丄 14.i; L.94.1.14.V; L.94 丄 15.i ; L.94.I.15.V; L.94 丄 18.i; L.94 丄 18.v; L.94 丄 25.i; L94.I.25.V; L.94.mAi; L. .94.xn.4.v; L.94.m.6.i; Ι-94.ιη · 6.ν; L.94.in.ll.i; L.94.rrt.ll: v; L .94.m.l4.i; L.94.m.l4.v; L.94.m, 15.i; L.94.m.l5.v; 35 L.94.m.l8.i; L.94.m.l8.v; L.94.m.25.i; L.94.m.25.v; L.94.〇.4.i; L.94.o.4.v; L.94.o.6.i; Consumer Co-operation of the Central Standards Bureau of the Ministry of Economic Affairs, printed by L.94.0.6.V; L.94.o.ll.i; L.94.o.ll.v; L.94.o.l4.i; L.94.0.14.V; L.94.o.l5.i; L.94.0.15.V; L.94.o.l8.i; L.94.0. 18.V; L.94.o.25.i; L.94.o.25.v; 0.93.a.4.i; 0.93.a.4.v; 0.93.a.6.i; 0.93. a.6.v; 0.93.a.ll.i; 0.93.a.ll.v; 0.93.a.l4.i; 0.93.a.l4.v; 0.93.a.l5.i; 0.93. a.l5.v; 0.93.a.l8.i; 0.93.a.l8.v; 0.93.a.25.i; 0.93.a.25.v; 0.93.e.4.i; 0.93.e. 4.v; 40 0.93.e.6.i; 0.93.e.6.v; 0.93.e.ll.i; 0.93.e.ll.v; 0.93.e.l4.i; 0.93.e.l4 .v; 0.93.e.l5.i; 0.93.e.l5.v; 0.93.e.l8.i; 0.93.e.l8.v; 0.93.e.25.i; 0.93.e.25.v ; 0.93.g.4.i; 0.93.g.4.v; 0.93.g.6.i; 0.93. g.6.v; 0.93.g.ll.i; 0.93.g.ll.v; 0.93.g.l4.i; 0.93.g.l4.v; 0.93.g.l5.i; 0.93. g.l5.v; 0.93.g.lS.i; 0.93.g.l8.v; 0.93.g.25.i; 0.93.g.25.v; 0.93.1.4.1; 0.93.1.4.V; 0.93.1.6.Ϊ; 0.93.1,6.v; 0.93.1.11.:; 0.93.1.11.V; 0.93.1.14.i; 0.93.1.14.V; 0.93.1.15.1; 45 0.93 丄 15.v ; 〇.93.1.1S.i; 〇.93 丄 18, v; 0.93_1 · 25 · ί; 〇.93 丄 25.v; 0.93.m.4.i; 0.93.m.4.v; 0.93. m.6.i; 0.93.m.6.v; 0.93.m.ll.i; 〇93.m.ll.v; 〇93.m.l4.i; 0.93.m.14.v; .0.93.m.l5.i; 0.93.m.15.v; 0.93.m.l8.i; 0.93.m.l8.v; 0.93.m.25.i; 0.93.m.25.v; 0.93 .o.4-.i; O.93.0.4.V; 0.93.o.6.i; 0.93.〇.6.v; 0.93.o.ll.i; 0.93.o.ll. v; 0.93.o.l4.i ;, this paper size is applicable to + Soul_Home Block Standard (CNS) Λ4 specification (2 丨, male stem) 426663; V. Description of the invention (133) A7 B7 Central Bureau of Standards, Ministry of Economic Affairs Printed by the employees' cooperatives 0 · 93.ο · 14 · ν; 0.93.0Λ5 j; 0 · 93, ο · 15 · ν; 0 · 93 · α18-ί; 0 · 93, ο · 18 · ν; 0.93 · Ο.25-ί; 0.93.0.25.V; 0.94.a.4.i; 0.94.a.4-v; 0.94.a.6.i; 0.94.a, 6.v; 0.94.a.ll .i; 0,94.a.ll.v; 〇.94, a.l4.i; 0 .94.a.l4.v; 0.94.a.l5.i; 0.94a.l5.v; 0.94.a, 18.i; 0.94.a.l8-v; 0.94.a.25i; 〇. 94.a.25.v; 0.94.e.4.i; 0.94.e.4.v; 0.94.e.6.i; 0.94.e.6.v; 0.94.e.lla; 5 0.94.e .ll, v; 0.94re.l4A; 0.94.e.l4.v; 0.94, e.l5.i; 0.94.e.l5.v; 0.94.e.l8, i; 0.94, e.l8. v; 0.94.e.25.i; 0.94.e-25.v; 0.94.g_4.i; 0.94.g.4.v; 0.94.g.6.i; 0.94.g.6.v; 0.94. g, ll.i; 0-94.g.ll.v; 0.94.g.l4.i; 0.94. &14v;0'94.g.l5.i; 0.94.g.l5- v; 0.94.g.l8.i; 0.94.g.l8.v; 0.94, g.25.i; 0.94.g.25 * v; 0.94.L4j; 0.94J.4_v; 0.94.Ι.6.Ϊ ; 0.94 丄 6.v; 0.94.L1U; CX94 丄 ll.v; 0.94 丄 14.i; 0.94 丄 M * v; 0.94 丄 15.i; a94.1, 15.v; 10 0.94 丄 18 · ί; 0.94.1.18v; 0.94 丄 25.i; 0.94.L25.V; 0.94.m.4i; 0.94.m.4.v; 0.94.m, 6.i; O, 94.1X1.6.v; 0.94 .m.ll.i; 0.94.m.ll.v; 0.94.m.l4.i; 0.94, m.l4.v; 0.94.m.l5.i; 0.94.m.l5.v; 0.94 .m.l8.i; 0.94.m.l8.v; 0.94.m.25.i; 0.94.m.25.v; 0.94.o * 4.i; CX94.oAv; 0.94 · ο · 6, ί ; 0.94 * ο · 6 · ν; 0.94 · ο_Π, ί; 0 · 94.ο.11λγ; 0_94 * o.l4.i; 0.94 · ο · 14 · ν; CX94, o.l5.i; 0.94.0 J5.v; 0 * 94 · ο.18Λ; 0 * 94 .ο.18 · ν; 0 · 94 · ο.25Λ; 0 · 94 · ο_25 · ν; 15 P.93.a.4.i; P.93.aAv; P.93.a.6.i; P.93.a, 6.v; P.93.a.ll.i; P.93.a.ll.v; P.93.a.l4.i; P. 93.a.l4: v; P.93.a.l5.i; P.93.a.l5.v; P.93.a, 18.i; P.93.a.l8.v; P.93, a.25i; P.93.a. 93.a.25.v; P.93.e.4.i; P.93.e.4, v; P.93 + e.6.i; P.93.6-6.ν; P.93. e.ll.i; P-93.e.ll * v; P.93.e.l4.i; P.93.e.l4.v; P.93.e.l5.i; P.93. e.l5.v; P.93.e.l8.i; P.93.e.l8 * v; P.93.e.25.i; P.93.e.25 * v; P.93. g.4, i; P.93.g.4.v; P, 93.g.6.i; P.93.g.6-v; P.93.g.ll.i; P.93. g.lLv; P.93.g.l4j; 20 P, 93.g.l4_v; P.93.g.l5.i; P.93.g.l5.v; P, 93.g, 18.i ; P, 93.g.l8.v; P.93, g.25.i; P.93.g, 25.v; P.93,1.4.i; P.93.L4.V; P.93 .L6.1; R93.1.6.V; P.93.1.1U; R93J.11.V; P, 93.L14.i; P · 93 · 1Λ4.ν; R93.U5 ″; R93.115, v; R93 丄 18.i; P.93 丄 18.v; R93 丄 25.i; P · 93 · Ι.25 · ν; P.93.m.4.i; P, 93.m.4.v; P.93.m.6.i; P, 93.m.6.v; P.93.m.ll.i; P-93.m.ll.v; P.93.m.l4.i; P.93.m, 14.v; F.93.m.l5.i; P.93, m.l5.v; P.93 * m, 18.i; P.93.m.18.v; 25 P.93.m.25.i; P.93.m.25, v; P · 93.〇 · 4.ί; Ρ_93 · ο · 4.ν; P, 93- , 6.i; P_93, o.6.v; P.93.o, ll.i; R93.o.ll.v; ρ · 93'ο · 14.ί; ρ · 93 · ο · 14 · ν Ρ, 93.ο · 15 · ί; ρ, 93, ο15 · ν; P, 93.o.l8.i; Ρ.93 · ο, 18 · ν; Ρ.93, ο.25ά; Ρ, 93 .〇.25.ν; P, 94.a * 4.i; P * 94.a.4.v; P.94.a.6.i; P.94.a * 6, v; P.94 .a.ll.i; P.94.a.11.v; P.94.a, 14, i; P.94.a.l4.v; P.94.a.l5.i; P.94 .a.l5.v; P.94.a, 18.i; P.94, a.l8.v; P * 94.a.25.i; P.94.a.25.v; P.94 .e, 4.i; P.94.e.4.v; F.94, e.6i; P.94, e.6.v; P.94.e.ll, i; 30 P.94. e.ll, v; P.94.e.l4 * i; P.94.e.l4.v; P, 94.e.l5a; P * 94.e, 15.v; P, 94.e. l8i; P.94.e, 18.v; P, 94.e.25.i; P.94.e.25.v; P, 94.g.4, i; P.94.g.4. v; P.94.g.6i; P.94.g.6.v; P.94.g, lli; P.94, g.ll.v; P.94.g.l4.i; P.94 94.g.l4, v; P.94.gl5.i; P, 94.g.l5.v; P.94.g.l8.i; P, 94.g * 18.v; P.94, g.25.i; P.94.g.25.v; P.94.L4.i; P.94.L4.V; P.94.L6i; P.94.1.6.V; P.94. 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US.i; P.94 丄 lS.v; 35 P.94.L25, i; P.94.L25.V; P.94.m.4.i; P.94.m.4.v; P .94.m.6.i; P, 94.m, 6.v; P.94, m.lLi; P.94.m.ll.v; P.94.m.l4.i; P-94 .m.l4 .v; P.94-m.l5.i; P.94.m.l5.v; P.94.m.l8, i; P.94.m.l8.v; P.94m.25.i ; P.94 * m.25.v; P.94.0.4Λ; P.94.o.4.v; P.94.o * 6.i; P.94.o.6.v; P.94 .o.ll.i; P.94.0.11.V; P.94.o.l4.i; P.94.0.14.V; P.94.o.l5.i; P.94.o.l5 .v; R94.o.l8.i; P.94.0.18.V; P.94.o.25.i; P-94.o.25.v; A.2.a.4.o; A 2..2.a.4.bh; A.2.a.4.bi; A.2.a.4, bj; 40 A.2.a.4.bk; A, 2.a.ll.o; A.2.a, ll.bh; A.2, a.ll.bi; A.2.a.ll.bj; A.2 * a.lLbk; A.2.a.l5.i; A- 2.a.l5.o; A.2, a.l5.bh; A.2.a.l5.bi; A.2.a.l5.bj; A.2.a.l5.bk; A. 2.a37.i; A.2.a.37.o; A.2.a.37.bh; A.2.a.37_bi; A.2.a.37.bj; A.2.a. 37.bk; A.2.a.38.i; A.2.a.38.o; A.2.a.3S.bh; A2.a38.bi; A.2.a.38.bj; A.2, a.38.bk; A.2.a.39.i; A.2.a.39.o; A2.a.39.bh; A.2.a.39.bi; A. 2.a.39, bj; A.2.a.39, bk; A.2.a, 40.i; A.2.a.40.o; A.2.a.40.bh; A. 2.a.40 * bi; A.2.a.40.bj; 45 A.2.a.40.bk; A, 2.a.41.i; A2.a, 41.o; A.2 .a, 41.bh; A.2.a.41.bi; A, 2.a.41.bj; A.2.a.41.bk; A.2.a.42.i; A.2 .a.42.o; A.2.a.42.bh; A2.a.42, bi; A.2, a.42.bj; A.2.a.42 * bk; A.2.a .43.i; A * 2.a.43, o; A * 2, a.43-bh; A2.a.43.bi; A * 2.a, 43.bj; A, 2.a.43 .bk; A.3, a .4.o; A.3.a.4.bh; A.3.a.4.bi; A.3.a.4.bj; A.3.a.4.bk; A3.a, ll , o; A3.a.lLbh; Please read the note of Si first. f The paper size of the edition is applicable to the Chinese National Standard (CNS) Λ4 Regulations 丨 M 21〇 × mm) 136-Work of the Central Standards Bureau of the Ministry of Economic Affairs Printed by the consumer cooperative Λ2β66 3, _ ^ ___ V. 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(Page order) line A7 B7 426663 V. Description of the invention (135) A.19.a.38.o; A.19, a.38.bh; A.19.a.38.bi; A.19.a. 38.bj; A.19.a.3S.bk; A.19.a.39.i; A.19, a.39.o; A.19.a.39.bh; A.19.a. 39.bi; A.19.a.39.bj; A.19.a.39.bk; A.19.a.40.i; A.19.a.40.o; A.19.a. 40.bh; A.19.a.40.bi; A.19.a.40.bj; A.19.a.4〇.bk; A.19.a.41.i; A.19.a .41.o; A.19.a.41.bh; A.19.a.41.bi; A.19.a.41.bj; A.19.a.41.bk; A.19.a .42.i; 5 A.19.a.42.o; A.19.a.42.bh; A.19.a.42.bi; A.19.a.42.bj; A.19. a.42.bk; A.19.a.43.i; A.19.a.43.o; A.19.a.43.bh; A-19.a.43.bi; A.19. a.43.bj; A.19.a.43.bk; A.97.a.4.i; A.97.a.4.o; A.97.a.4.bh; A.97. a.4.bi; A.97.a.4.bj; A.97.a.4.bk; A.97.a.ll.i; A.97, a.ll.o; A.97. a.ll.bh; A.97.a.ll.bi; A.97.a.ll.bj; A.97.a.ll.bk; A.97.a.l5.i; A.97. a.l5.o; A.97.a.l5.bh; A.97.a.l5.bi; A.97.a.l5.bj; A.97.a.l5.bk; A.97. a.37.i; 10 A.97.a.37.o; A.97.a.37.bh; A.97.a.37.bi; A.97.a.37.bj; A.97 .a.37.bk; A.97.a.38.i; A.97.a.3S.o; A.97.a.38.bh; A.97.a.38.bi; A.97 .a.38.bj; A.97.a.38.bk; A.97.a.39.i; A.97.a.39.o; A.97.a.39.bh; A.97 .a.39.bi; A.97.a.39.bj; A.97.a.39.bk; A.97.a.40.i; A.97.a.40.o; A.97.a.40.bh; A.97.a.40.bi; A.97.a.40.bj; A.97.a.40.bk; A.97.a.41.i; A.97.a.41.o; A.97.a.41.bh; A.97.a.41.bi; A.97.a.41.bj; A.97.a.41.bk; A.97.a.42.i; 15 A.97.a.42.〇; A-97.a.42.bh; A.97.a.42.bi; A.97.a.42.bj; A.97.a.42.bk ; A.97.a.43.i; A.97.a.43.o; A.97.a.43.bh; A.97.a.43.bi; A.97.a.43.bj ; A.97.a.43.bk; A.98.a.4.i; A.98.a.4.o; A.98.a.4.bh; A.98.a.4.bi ; A.98.a.4.bj; A.98.a.4.bk; A.98.a.ll.i; A.98.a.ll.o; A.98.a.ll.bh ; A.98.a.Xl.bi; A.98.a.ll.bj; A.98.a.ll, bk; A.98.a.l5.i; A.98.a.l5.o ; A.98.a.l5.bh; A.98.a.l5.bi; A.98.a.l5.bj; A.98.a.l5.bk; A.98.a.37.i ; 20 A.98.a.37.o; A.98.a.37.bh; A.98.a.37.bi; A.98.a.37.bj; A.98.a.37. bk; A.98.a.38.i; A.9S.a.38.o; A.98.a.38.bh; A.98.a.38.bi; A.98.a.38. bj; A.98.a.38.bk; A.98.a.39.i; A.98.a.39.o; A.98.a.39.bh; A.98.a.39. bi; A.98.a.39.bj; A.98.a.39.bk; A.98.a.40.i; A.98.a.40.o; A.98.a.40. bh; A.98.a, 40.bi; A.98.a.40.bj; A.98.a.40.bk; A.98.a.41.i; A.98.a.41. o; A.98.a.41.bh; A.98.a.41.bi; A.98.a.41.bj; A.98.a.41.bk; A.98.a.42.1; 25 A.98.a.42.o; A.98.a.42.bh; A.98.a.42.bi; A .98.a.42.bj; A.98.a.42.bk; A.98.a.43.i; A.98.a.43.o; A.98.a.43.bh; A .98.a.43.bi; A.98.a.43.bj; A.98.a.43.bk; A.2.a.4.i; A.3.a.4.i; A .4.a.4.i; A.5.a.4.i; A.6.a.4.i; A.7.a.4.i; A.9.a.4.i; A. .10.a.4.i; A.15.a.4.i; A.100.a.4.i; A.101.a.4.i; A.102.a.4.i; A .103.a.4.i; A.104.a.4.i; A.105.a.4.i; A.106.a.4.i; A.107.a.4.i; A. .108.a.4.i; A.109.a.4.i; A.110.a.4.i; A.lll.a.4.i; A.112.a.4.i; A. .113.a.4.i; 30 A.114.a.4.i; A.115.a.4.i; A.116.a.4.i; A.117.a.4.i; A.118.a.4.i; A.119.a.4.i; A.120.a.4.i; A.121.a.4.i; A.122.a.4.i; A.123.a.4.i; A.124.a.4.i; A.125.a.4.i; A.126.a.4.i; A.127.a.4.i; A.128.a.4.i; A.129.a.4.i; A.13〇.a.4.i; A.131.a.4.i; A.132.a.4.i ; A.133.a.4.i; A.134.a.4.i; A.135.a.4.i; A.136.a.4.i; A.137.a.4.i ; A.138.a.4.i; A.139.a.4.i; A.140.a.4.i; A.141.a.4.i; A.142.a.4.i ; A.143.a.4.i; A.144.a.4.i; A.145.a.4.i; A.146.a.4.i; A.147.a.4.i ; A.148.a.4.i; 35 A.149.a.4.i; A.150.a.4.i; A.151.a.4.i; A.152.a.4. i; A.153.a.4.i; A.154.a. 4.i; A.155.a.4.i; A.156.a.4.i; A.157.a.4.i; A.158.a.4.i; A.159.a. 4.i; A.160.a.4.i; A.161.a.4.i; A.162.a.4.i; A.163.a.4.i; A.164.a. 4.i; A.165, a.4.i; A.166.a.4.i; A.167.a.4.i; A.168.a.4.i; A.169.a. 4.i; A.170.a.4.i; A.171.a.4.i; A.172.a.4.i; A.173.a.4.i; A.174.a. 4.i; A.175.a.4.i; A.176.a.4.i; A.177.a.4.i; A.178.a.4.i; A.179.a. 4.i; A.180.a.4.i; A.181.a.4.i; A.182.a.4.i; A.183.a.4.i; 40 A.184.a .4.i; A.185.a.4.i; A.186.a.4.i; A.187.a.4.i; A.188.a.4.i; A.189.a .4.i; A.190.a.4.i; A.191.a.4.i; A.192.a.4.i; A.193.a.4.i; A.194.a .4.i; A.l95.a.4.i; A.196.a.4.i; A.197.a.4a; A.19S.a.4.i; A.199.a.4 .i; A.200.a.4.i; A.201.a.4.i; A.202.a.4.i; A.203.a.4.i; A.204.a.4 .i; A.205.a.4.i; A.206.a.4.i; A.2〇7.a.4.i; A.208.a.4.i; A.209.a .4.i; A.210.a.4.i; A.211.a.4.i; A.212.a.4.i; A.213.a.4.i; A.214.a .4.i; A.215.a.4.i; A.216.a.4.i; A.217.a.4.i; A.218.a.4.i; 45 A.219. a.4.i; A.220.a.4.i; A.221.a.4.i; A.222.a.4.i; A.223.a.4.i; A.224. a.4.i; A.225.a.4.i; A.226.a.4.i; A.227.a.4.i; A.228.a.4.i; A.229. a.4.i; A.230.a.4.i; A.231.a.4.i; A.232.a.4.i; A.233.a.4.i; A.234.a.4.i; A.235.a.4.i; A.236.a.4.i; A.237.a.4.i; A.238.a.4.i; A.239.a.4.i; A.240.a.4.i; A.241.a.4.i; A.242.a.4.i; A.243.a.4.i; A.244.a.4.i; A.245.a.4.i; A.246.a.4.i; The paper size is in accordance with the Chinese National Standard (CNS); \ 4 specifications (210X other public quarantine diseases) _ i38 _ Please read the notes on the back first

Order printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs 426663 A7 B7 V. Description of the invention (136) 10 15 20 25 35 Printed by the Shellfish Consumer Cooperative of the China Standards Bureau of the Ministry of Economic Affairs 45 A.247.a, 4.i; A .248.a.4, i; A.249, a.4.i; A.250.a.4.i; A.251.a.4.i; A.251a.4.i; A, 253 .a.4.i; A.254.a.4.i; A.255, a.4.i; A.256.a, 4.i; A.257.a.4.i; A.258 .a.4.i; A.259.a.4.i; A.260.a.4.i; A.26l.a.4.i; A.262.a.4.i; A.263 .a * 4.i; A.264.a.4.i; A.265.a.4.i; A.266.a.4.i; A.267.a.4.i; A.268 .a.4.i; A.269.af4.i; A.270.a.4.i; A.271.a.4.i; A.272.a4.i; A.273.a.4 .i; A.274.a.4_i; A.275.a, 4.i; A, 276.aAi; A.277.a.4.i; A.278.a.4.i; A.279 .a.4_i; A.28〇.a.4.i; A.281.a.4.i; A.282.a.4.i; A.283.a.4.i; A.284a. 4.i; A, 285.a.4.i; A.286.a.4.i; A.287.a.4.i; A.288.a.4.i; A.289.a * 4.i; A.290_a.4.i; A.291.a.4.i; A.292.a.4.i; A.293.aAi; A.294.aAi; A.295.a. 4.i; A.296.a.4.i; A.297.a.4.i; A.298.a.4.i; A.299.a.4i; A.300.a.4. i; A.301.aAi; A.302.a.4.i; A-303.a.4.i; A.304.a.4.i; A.305.a.4.i; A. 306.a.4.i; A.307.a.4.i; A, 308.a.4i; A.309, a.4i; A.310.aAi; 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A.588.a.4.i; A.589.a.4.i; A.590.a.4.i; A .591.a.4.i; A.592.a.4.i; A.593.a.4.i; A.594.a.4.i; A.595.a.4.i; A .596.a.4.i; A.597.a.4.i; A.598.a.4.i; A.599.a.4.i; A.600.a.4.i; A. .601.a.4.i; A.602.a.4.i; A.603.a.4.i; A.604.a.4.i; A.605.a.4.i; A .606.a.4.i; A.607.a.4.i; A.608.a.4.i; A.609.a.4.i; A.610.a.4.i; 5 A.611.a.4.i; A.61 2.a.4.i; A.613.a.4.i; A.614.a.4.i; A.615.a.4.i; A.616.a.4.i; A. 617.a.4.i; A.618.a.4.i; A.619.a.4.i; A.620.a.4.i; A.621.a.4.i; A. 622.a.4.i; A.623.a.4.i; A.624.a.4.i; A.625.a.4.j; A.626.a.4.i; A. 627.a.4.i; A.628.a.4.i; A.629.a.4.i; A.630.a.4.i; A.63La.4.i; A.632. a.4.i; A.633.a.4.i; A.634.a.4.i; A.635.a.4.i; A.636.a.4.i; A.637. a.4.i; A.638.a.4.i; A.639.a.4.i; A.640.a.4.i; A.641.a.4.i; A.642. a.4.i; A.643.a.4.i; A.644.a.4.i; A.645.a.4.i; 10 A.646.a.4.i; A.647 .a.4.i; A.648.a.4.i; A.649.a.4.i; A.650.a.4.i; A.651.a.4.i; A.652 .a.4.i; A.653.a.4.i; A.654.a, 4.i; A.655.a.4.i; A.656.a.4.i; A.657 .a.4.i; A.658.a.4.i; A.659.a.4.i; A.660.a.4.i; A.2.a.ll.i; A.3 .a.ll.i; A.4.a.ll.i; A.5.a.ll.i; A.6.a.ll.i; A.7.a.ll.i; A.9 .a.ll.i; A.10.a.ll.i; A.15.a.ll.i; A.lOO.a.ll.i; A.lOl.a.ll.i; A.102 .a.ll.i; A.103.a.ll.i; A.104.aUi; A.105.a.ll.i; A.106.a.ll.i; A.107.a.ll .i; A.108.a.ll.i; 15 A.109.a.ll.i; A.llO.a.ll.i; A.lll.a.ll.i; A.112.a. ll.i; A.113.a.ll.i; A.114.a.ll.i; A.115.aUi; A.116.a.ll.i; A.117.a.ll.i ; A.118.a.ll.i; A.119.a.ll.i; A.120.a.ll.i; A.121.a.ll.i; A.122.a.ll.i ; A.123.a.ll.i; A.124.a.ll.i; A.125.a.ll.i; A.126.a.ll.i; A.127.a.ll.i ; A.128.a.ll.i; A.129.a.ll.i; A.130.a.ll.i; A.131.aUi; A.132.a.ll.i; A.133 .a.ll.i; A.134.a.ll.i; A.135.a.ll.i; A.136.a.ll.i; A.137.a.ll.i; A.138 .a.ll.i; 20 A.139.a.ll.i; A.140.a.ll.i; A.141.a.ll.i; A.142.a.ll.i; A. 143.a.ll.i; A.144.a.ll.i; A.145.a.ll.i; A.146.a.ll.i; A.147.a.ll.i; A. 148.a.ll.i; A.149.a.ll.i; A.150.a.ll.i; A.151.a.lU; A.152.a.ll.i; A.153. a.ll.i; A.154.a.ll.i; A.155.a.ll.i; A.156.a.ll.i; A.157.a.ll.i; A.lSS. a.ll.i; A.159.a.ll.i; A.160.a.ll.i; A.161.a.ll.i; A.162.a.ll.i; A.163. a.ll.i; A.164.a.ll.i; A.165.a.ll.i; A.166.a.ll.i; A.167.a.ll.i; A.168. a.ll.i; 25 A.169.a.ll.i; A.170.a.ll.i; A.171.a.ll.i; A.172.a.ll.i; A.173 .a.ll.i; A.174.a.ll.i; A.175.a.ll.i; A.176.a.ll.i; A.177.a.ll.i; A.178 .a.ll.i; A.179.a.ll.i; A.180.a.ll.i; A.181.a.ll.i; A.182.a.ll.i; A.183 .a.ll.i; A.184.a.ll.i; A.l85.a.ll.i; A.186.a.ll.i; A.187 .a.ll.i; A.188.a.ll.i; A.189.a.ll.i; A.190.a.ll.i; A.191.a.ll.i; A.192 .aUi; A.193.a.ll.i; A.194.a.ll.i; A.195.a.ll.i; A, 196.a.ll.i; A.197.aUi; A .198.a.ll.i; 30 A.199.a.ll.i; A.200.a.ll.i; A.201.a.ll.i; A.202.a.ll.i; A.203.a.lla; A.204.a.ll.i; A.205.a.ll.i; A.206.a.ll.i; A.207.a.ll.i; A. 208.a.ll.i; A.209.a.ll.i; A.210.a.ll.i; A.211.a.ll.i; A.212.a.ll.i; A. 213.a.ll.i; A.214.aUi; A.215.a.ll.i; A.216.a.ll.i; A.217.a.ll.i; A.218.a. ll.i; A.219.a.ll.i; A.220.a.ll.i; A.221.a.ll.i; A.222.a.ll.i; A.223.a. ll.i; A.224.a.ll.i; A.225.a.ll, i; A.226.a.ll.i; A.227.a.ll.i; A.228.a. ll.i; 35 A.229.a.ll.i; A.230.a.ll.i; A.231.a.ll.i; A.232.a.ll.i; A.233.a .ll.i; A.234.a.ll.i; A.235.a.ll.i; A.236.a.ll.i; A.237.a.ll.i; A.238.a .ll.i; A.239.a.ll.i; A.240.a.ll.i; A.241.a.ll.i; A.242.a.ll.i; A.243.a .ll.i; A.244.a.ll.i; A.245.a.ll.i; A.246.a.ll.i; A.247.a.ll.i; A.248.a .ll.i; A.249.a.ll.i; A.250.a.ll.i; A.251.a.ll.i; A.252.a.ll.i; A.253.a .ll.i; A.254.a.ll.i; A.255.a.ll.i; A.256.a.ll.i; A.257.a .ll.i; A.258.a.ll.i; 40 A.259.a.ll.i; A.20〇.a.ll.i; A.261.a.ll.i; A.262 .a.ll.i; A.263.a.ll.i; A.264.a.ll.i; A.265.a.ll.i; A.266.a.ll.i; A.267 , a.ll.i; A.268.a.ll.i; A.269.a.ll.i; A.27〇.a.ll.i; A.271.a.ll.i; A. 272.a.ll.i; A.273.a.ll.i; A.274.a.ll.i; A.275.a.ll.i; A.276.a.ll.i; A. 277.a.ll.i; A.278.a.ll.i; A.279.a.ll.i; A.2S0.a.ll.i; A281.a.lU; A.2S2.a. ll.i; A.283.a.ll.i; A.284.a.ll.i; A.285.a.ll, i; A.286.aUi; A.2S7.a.ll.i; A.288.a.ll.i; 45 A.289.a.ll.i; A.290.a.ll.i; A.291.a.ll.i; A.292.a.ll.i ; A.293.a.ll.i; A.294.a.ll.i; A.295, a.ll.i; A.296.a.ll.i; A.297.a.ll.i ; A.298.a.ll.i; A.299.a.ll.i; A.300.a.ll.i; A.301.a.ll.i; A.302.a.ll.i ; A.303.a.ll.i; A.304.a.ll.i; A305.a.ll.i; A.306.a.ll.i; A.307.a.ll.i; A .308.a.ll.i; A.309.a.ll, i; A.310.a.ll.i; A.Sll.a.ll.i; A.312.a.ll.i; please Note on δτ before the back «D. Binding on this page) Thread paper size Applicable Chinese National Standard (CNS) Λ4 Specification (210X29 / Common) 140 42666 3 Λ V. Description of Invention (13 ) A.313.a.ll.i; A.314.a.ll.i; A.315.aUi; A.316.a.ll.i; A.317.a.ll.i; A.318 .a.ll.i; A.319.a.ll, i; A.320.a.ll.i; A.321.a.ll.i; A.323.a.ll.i; A.324 .a.ll.i; A.325.a.ll.i; A.326.a.ll.i; A.327.a.ll.i; A.328.a.ll.i; A.329 .a.ll.i; A.330.a.ll.i; A.331.a.ll.i; A.332.a.ll.i; A.333.a.ll.i; A.334 .a.ll.i; A.335.a.ll.i; A.336.a.ll.i; A.337.a.ll.i; 5 A.338.a.ll.i; A. 339.a.ll.i; A.340.a.ll.i; A.341.a.ll.i; A.342.a.ll.i; A.343.a.ll.i; A. 344.a.ll.i; A.345.a.ll.i; A.346.a.ll.i; A.347.a.ll.i; A.348.a.ll.i; A. 349.a.ll.i; A.350.a.ll.i; A.351.a.ll.i; A.352.a.ll.i; A.353.a.ll.i; A. 354.a.ll.i; A.355.a.ll.i; A.356.a.ll.i; A.357.a.ll.i; A.358.a.ll.i; A. 359.a.ll.i; A.360.aUi; A.361.a.ll.i; A.362.a.ll.i; A.363.a.ll.i; A.364.a. ll.i; A.365.a.ll.i; A.366.a.ll.i; A.367.a.ll.i; 10 A.368.a.ll.i; A.369.a .ll.i; A.370.a.ll.i; A.371.a.ll.i; A.372.a.ll.i; A.373.a.ll.i; A.374.a .ll.i; A.375.a.Xl.i; A.376.a.ll.i; A.377.a.ll.i; A.378.a.ll.i; A, 379.a .ll.i; A.380.a.ll.i; A.381.a.ll.i; A.382.a.ll.i; A.383.a.ll.i; A. 384.a.ll.i; A.3S5.a.ll.i; A.386.a.lU; A.387.a.ll.i; A.388.a.ll.i; A.389. a.ll.i; A.390.aUi; A.391.a.ll.i; A.392.a.ll.i; A.393.a.ll.i; A.394.a.ll. i; A.395.a.ll.i; A.396.a.ll.i; A.397.a.ll.i; 15 A.398.a.ll.i; A.399.a.ll .i; A.400.a.ll.i; A.401.a.ll.i; A.402.a.ll.i; A.403.a.ll.i; A.404.a.ll .i; A.405.a.ll.i; A.406.a.ll.i; A.407.a.ll.i; A.408.a.ll.i; A.409.a.ll .i; A.410.a.ll.i; A.411.a.ll.i; A.412.a.ll.i; A.413.a.lli; A.414.a.ll.i ; A.415.a.ll.i; A.416.a.ll.i; A.417.a.ll.i; A.418.a.ll.i; A.419.a.ll.i ; A.420.a.ll.i; A.421.a.ll.i; A.422.a.ll.i; A.423.a.ll.i; A.424.a.ll.i ; A.425.a.ll.i; A.426.a.ll.i; A.427.a.ll.i; 20 A.428.a.ll.i; A.429.a.ll. i; A.430.a.ll.i; A.431.a.ll.i; A.432.a.ll.i; A.433.a.ll.i; A-434.a.ll. i; A.435.a.ll.i; A.436.a.ll.i; A.437.a.ll.i; A.438.a.ll.i; A.439.a.ll. i; A.440.a.ll.i; A.441.a.ll.i; A.442.a.ll.i; A.443, a.ll.i; A.444.a.ll. i; A.445.a.ll.i; A.446.a.ll.i; A.447.a.ll.i; A.448.a.ll.i; A.449.a.ll. i; A.450.a.ll.i; A.451.a.ll.i; A.452.a.ll.i; A.453.a.ll.i; A.454.a.ll. i; A. 455.a.ll.i; A.456.a.ll.i; A.457.a.ll.i; 25 A.458.a.ll.i; A.459.a.ll.i; A .460.a.ll.i; A.461.a.ll.i; A.462.a.ll.i; A.463.a.ll.i; A.464.a.ll.i; A .465.a.ll.i; A.466.a.ll.i; A.467.a.ll.i; A.468.a.ll.i; A.469.a.ll.i; A .470.a.lLi; A.471.a.ll.i; A.472.a.ll.i; A.473.a.ll.i; A.474.a.ll.i; A.475 .a.ll.i; A.476.a.ll.i; A.477.a.ll.i; A.478.a.ll.i; A.479.a.ll.i; A.480 .a.ll.i; A.481.a.ll.i; A.482.a.ll.i; A.4S3.a.ll.i; A.484.a.ll.i; A.485 .a.ll.i; A.486.a.ll.i; A.487.a.ll.i; 30 A.488.a.ll.i; A.489.a.ll.i; A. 490.a.ll.i; A.491.a.ll.i; A.492.a.ll.i; A.493.a.ll.i; A.494.a.ll.i; A. 495.a.ll.i; A.496.a.ll.i; A.497.a.ll.i; A.498.a.ll.i; A.499.a.ll.i; A. 500, a.ll.i; A.SOl.aUi; A.502.a.ll.i; A.503.a.ll.i; A.504.a.ll.i; A.505.a. ll.i; A.506.a, ll.i; A.507.a.ll.i; A.SOS.a.ll.i; A.509.a.ll.i; A.510. a.ll.i; A.Sll.a.ll.i; A.512.a.ll.i; A.512.a.ll.i; A.513.a.ll.i; A.514. a.ll.i; A.515.a.ll.i; A.516.a.ll.i; 35 A.517.a.ll.i; A.518.a.ll.i; A.519 .a.ll.i; A.520.a.ll.i; A.521.a.ll.i; A.522.a.ll.i; Ministry of Economic Affairs Printed by the Central Standards Bureau Shellfish Consumer Cooperative A.523.a.ll.i; A.524.a.ll.i; A.525.a.ll.i; A.526.a.ll.i; A .527.a.ll.i; A.528.a.ll.i; A.529.a.ll.i; A.530.a.ll.i; A.531.a.ll.i; A .532.a.ll.i; A.533.a.ll.i; A.534.a.ll.i; A.535.a.ll.i; A.536.a.ll.i; A .537.a.ll.i; A.538.a.ll.i; A.539.a.ll.i; A.540.a.ll.i; A.541.a.ll.i; A .542.a.ll.i; A.543.a.ll.i; A.544.a.ll.i; A.545.a.ll.i; A.546.a.ll.i; 40 A.547.a.ll.i; A.54S.a.ll.i; A.549.a.ll.i; A.550.a.ll.i; A.551.a.ll.i; A.552.a.ll.i; A.553.a.ll.i; A.554.a.ll-i; A.555.a.ll.i; A.556.a.ll.i; A.557.a.ll.i; A.558.a.ll.i; A.559.a.ll.i; A.560.a.ll.i; A.56X.a.ll.i; A.562.a.ll.i; A.563.a.ll.i; A.564.a.ll.i; A.565.a.ll.i; A.566.a.ll.i; A.567.a.ll.i; A.568.a.ll.i; A.569.a.ll.i; A.570.a.ll.i; A.571.a.ll.i; A.572.a.ll.i; A.573.a.ll.i; A.574.a.ll.i; A.575.a.ll.i; A.576.a.ll.i; 45 A.577.a.ll.i; A.578.a.ll-i, 'A.579.a.11.i; A.580.a.11.i; A.581.a.ll. i; A.582.a.11.i; A.5S3.a.ll.i; A.584.a.ll.i; A.585.a.ll.i; A.586.a.ll. i; A.587.a.ll.i; A.588.a.ll.i; A.589.a.ll.i; A.59 0.a.ll.i; A.591.a.ll.i; A.592.a.ll.i; A.593.a.ll.i; A.594.a.ll.i; A. 595.aUi; A.596.a.ll.i; A.597.a.ll.i; A.598.a.ll.i; A.599.a.ll.i; A.600.a. ll.i; Guan Jiabiao _ (CNS) correction of this paper. (21GX2y7) & 141-4266 6 3: A7 B7 V. Description of the invention (139) 5 10 15 20 25 35 Employee Cooperative Copies 45 A.601.a.11.i; A.602.a.ll.i; A.603.a.ll.i; A, 604.a.11.i; A, 605. a.ll.i; A.606.a.ll.i; A.6Q7.a.ll.i; A.608.a.ll.i; A.609.a.Il.i; A.610. a.ll.i; A.611.a.ll.i; A.612.a.ll.i; A.613.a.ll.i; A.614.a.ll.i; A.615. a.ll.i; A.616.a.ll.i; A.617.a.ll.i; A.618.a.ll.i; A.6l9.a.ll.i; A.620. a.ll.i; A.621.a.ll.i; A.622.a.ll.i; A.623.a.ll.i; A.624.a.ll.i; A.625. a.ll.i; A.626.a.ll.i; A.627.a.ll.i; A.628.a.ll.i; A.629.a.ll.i; A.630. a.ll.i; A.631.a.ll.i; A.632.a.ll.i; A.633.a.ll.i; A.634.a.ll.i; A.635. a.ll.i; A.636.a.ll.i; A.637.a.ll.i; A.638.a.ll.i; A.639.a.ll.i; A.640. a.ll.i; A.641.a.ll.i; A.642.a.ll.i;, A.643.a.ll.i; A.644.a.ll.i; A.645 .a.ll.i; A.646.a.ll.i; A.647.al li; A.648.a.ll.i; A.649.a.ll.i; A.650.a.ll.i; A.651.a.ll.i; A-652.a.ll. i; A.653.a.ll.i; A.654.a.ll.i; A.655.a.ll.i; A.656.a.ll.i; A.657.a.ll. i; A.658.a.ll.i; A.659.a.ll.i; A.660.a.ll.i; A.2.b.4.i; A.3.b.4. i; A.4.b.4.i; A.5.b.4.i; A.6.b.4.i; A.7.b.4.i; A.9.b.4. i; A.10.b.4.i; A.15.b.4.i; A.100.b.4.i; A.101.b.4.i; A.102.b.4. i; A.103.b.4.i; A.104.b.4.i; A.105.b.4.i; A.106.b.4.i; A.107.b.4. i; A.108.b.4.i; A.109.b.4.i; A.110.b.4.i; A.lll.b.4.i; A.112.b.4. i; A.113.b.4.i; A.114.b.4.i; A.115.b.4.i; A.116.b.4.i; A.117.b.4. i; A.118.b.4.i; A.119.b.4.i; A.120.b.4.i; A.121.b.4.i; A.122.b.4. i; A.123.b.4.i; A.124.b.4.i; A.125.b.4.i; A.126.b.4.i; A.127.b.4. i; A.128.b.4.i; A.129.b.4.i; A.130.b.4.i; A.131.b.4.i; A.132.b.4. i; A.133.b.4.i; A.134.b.4.i; A.135.b.4.i; A.136.b.4.i; A.137.b.4. i; A.138.b.4.i; A.139.b.4.i; A.140.b.4.i; A.14Lb.4.i; A.142.b.4.i; A.143.b.4.i; A.144.b.4.i; A.145.b.4.i; A.146.b.4.i; A.147.b.4.i; A, 148.b.4.i; A.149.b.4.i; A.150.b.4.i; A.151.b.4.i; A.152.b.4.i; A.153.b.4.i; A.154.b .4.i; A.155.b.4.i; A.156.b.4.i; A.157.b.4.i; A.158.b.4.i; A.l59.b .4.i; A.160.b.4.i; A.161.b.4.i; A.162.b.4.i; A, 163.b.4.i; A.164.b .4.i; A.165.b.4.i; A.166.b.4.i; A.167.b.4.i; A.168.b.4.i; A.169.b .4.i; A.17Q.b.4.i; A.171.b.4.i; A.172.b.4.i; A.173.b.4.i; A.174.b .4.i; A.175.b.4.i; A.176.b.4.i; A.177.b.4.i; A.178.b.4.i; A.179.b .4.i; A.180.b.4.i; A.181.b.4.i; A.182.b.4.i; A.183.b.4.i; A.184.b .4.i; A.185.b.4.i; A.186.b.4.i; A.287.b.4.i; A.188.b.4.i; A.189.b .4.i; A.190.b.4.i; A.191.b.4.i; A.192.b.4.i; A.193.b.4.i; A.194.b .4.i; A.195.b.4.i; A.196.b.4.i; A.197.b.4.i; A.198.b.4.i; A.199.b .4.i; A.200.b.4.i; A.201.b.4.i; A.202.b.4.i; A.203.b.4.i; A.204.b .4.i; A.205.b.4.i; A.206.b.4.i; A.207.b.4.i; A.20S.b.4.i; A.209.b .4.i; A.210.b.4.i; A.211.b.4.i; A.212.b.4.i; A.213.b.4.i; A.214.b .4.i; A.215.b.4.i; A.216.b.4.i; A.217.b.4.i; A.218.b.4.i; A.219.b .4.i; A.220.b.4.i; A.221.b.4.i; A.222.b.4.i; A.223.b.4.i; A.224.b .4.i; A.225.b.4.i; A.226.b.4.i; A.227.b.4.i; A.228.b.4.i; A.229.b .4.i; A.230.b.4.i; A. 231.b.4.i; A.232, b.4.i; A.233.b.4.i; A.234.b.4.i; A.235.b.4.i; A. 236.b.4.i; A.237.b.4.i; A.238.b.4.i; A.239.b.4.i; A.240.b.4.i; A. 241.b.4.i; A.242.b.4.i; A.243, b.4.i; A.244.b.4.i; A.245.b.4.i; A. 246.b.4.i; A.247.b.4.i; A.248.b.4.i; A.249.b.4.i; A.250.b.4.i; A. 251.b.4.i; A.252.b.4.i; A.253.b.4.i; A.254.b.4.i; A.255.b.4.i; A. 256.b.4.i; A.257.b.4, i; A.258.b.4.i; A.259.fa.4.i; A.260.b.4.i; A. 261, b.4.i; A.262.b.4.i; A.263.b.4.i; A.264.b.4.i; A.265.b.4.i; A. 266.b.4.i; A.267.b.4.i; A.268.b.4i; A.269.b.4.i; A.270.b.4.i; A.271. b.4.i; A.272.b.4.i; A.273.b.4.i; A.274.b.4.i; A.275.b.4.i; A.276. b.4.i; A.277.b.4.i; A.278.b.4, i; A.279.b.4.i; A.280.b.4.i; A.2Sl. b.4.i; A.282.b.4.i; A.283.b.4.i; A.284.b.4.i; A.285.b.4.i; A.286. b.4.i; A.287.b.4.i; A.288.b.4.i; A.289.b.4.i; A.290.b.4.i; A.291. b.4.i; A.292.b.4.i; A.293.b.4.i; A.294.b.4.i; A.295.b.4.i; A.296. b.4.i; A.297.b.4.i; A.298.b.4.i; A.299.b.4.i; A.300.b.4.i; A.301. b.4.i; A.302.b.4.i; A.303.b.4.i; A.304.b.4.i; A.305.b.4.i; A.306. b.4.i ; A.307.b.4.i; A.308.b.4.i; A.309.b.4.i; A.310.b.4.i; A.311.b.4.i ; A.312.b.4.i; A.313.b.4.i; A.314.b.4.i; A.315.b.4.i; A.316.b.4.i ; A.317.b.4.i; A.318.b.4.i; A.319.b.4.i; A.320.b.4.i; A.321.b.4.i ; A.323.b.4.i; A.324.b.4.i; A.325.D.4.i; A326.b.4.i; A.327.b.4.i; A. .328.b.4.i; A.329.b.4.i; A.330.b.4.i; A.331.b.4.i; A.332.b.4.i; A. .333.b.4.i; A.334.b.4.i; A.335.b.4.i; A.336.b.4.i; A.337.b.4.i; A .338.b.4.i; A.339.b.4.i; A.340.b.4.i; A.341.b.4.i; A.342.b.4.i; A .343.b.4.i; A.344.b.4.i; A.345.b.4.i; A.346.b.4.i; A.347.b.4.i; A .348.b.4.i; A.349.b.4.x; A.350.b.4.i; A.351.b.4.i; A.352.b.4.i; A. .353.b.4.i; A.354.b.4.i; A.355.b.4.i; A.356.b.4.i; A.357.b.4.i; A .358.b.4.i; The standard of this paper is applicable, and the country's Min Family Practice (CNS) Λ4 is 210XUV mm. 142-Please read the precautions for reading. 63, l] V. Description of the invention (14 °) A.359.b.4.i; A.360.b.4.i; A.361.b.4.i; A.362.b.4. i; A.363.b.4.i; A.364.b.4.i; A.365.b.4.i; A.366.b.4.i; A.367.b.4. i; A.36 8.b.4.i; A.369.b.4.i; A.370.b.4.i; A.371.b.4.i; A.372.b.4.i; A. 373.b.4.i; A.374.b.4.i; A.375.b.4.i; A.376.b.4.i; A.377.b.4.i; A. 378.b.4.i; A.379.b.4.i; A.380.b.4.i; A.381.b.4.i; A.382.b.4.i; A. 383.b.4.i; A.384.b.4.i; A.385.b.4.i; A.386.b.4.i; 5 A.387.b.4.i; A .388.b.4.i; A.389.b.4.i; A.390.b.4.i; A.391.b.4.i; A.392.b.4.i; A .393.b.4.i; A.394.b.4.i; A.395.b.4.i; A.396.b.4.i; A.397.b.4.i; A .398.b.4.i; A.399.b.4.i; A.400.b.4.i; A.401.b.4.i; A.402.b.4.i; A .403.b.4.i; A.404.b.4.i; A.405.b.4.i; A.406.b.4.i; A.407.b.4.i; A .408.b.4.i; A.409.b.4.i; A.410.b.4.i; A.411.b.4.i; A.412.b.4.i; A. .413.b.4.i; A.414.b.4.i; A.415.b.4.i; A.416.b.4.i; A.417.b.4.i; A .418.b.4.i; A.419.b.4.i; A.420.b.4.i; A.421.b.4.i; 10 A.422.b.4.i; A.423.b.4.i; A.424.b.4.i; A.425.b.4.i; A.426.b.4.i; A.427.b.4.i; A.428.b.4.i; A.429.b.4.i; A.430.b.4.i; A.431.b.4.i; A.432.b.4.i; A.433.b.4.i; A.434.b.4.i; A.435.b.4.i; A.436.b.4.i; A.437.b.4.i; A.438.b.4.i; A.439.b.4.i; A.440.b.4.i; A.441.b.4.i; A.442.b.4.i; A.443.b.4.i; A.444.b.4.i ; A.445.b.4.i; A.446.b.4.i; A.447.b.4.i; A.448.b.4.i; A.449.b.4.i ; A.45〇.b.4.i; A.451.b.4.i; A.452.b.4.i; A.453.b.4.i; A.454.b.4. i; A.455.b.4.i; A.456.b.4.i; A.457.b.4.i; A.458.bAi; A.459.b.4.i; A. 460.b.4.i; A.461.b.4.i; A.462.b.4.i; A.463.b.4.i; A.464.b.4.i; A. 465.b.4.i; A.466.b.4.i; A.467.b.4.i; A.468.b.4.i; A.469.b.4i; A.470. b.4.i; A.471.b.4.i; A.472.b.4.i; A.473.b.4.i; A.474.b.4.i; * A.475 .b.4.i; A.476.b.4.i; A.477.b.4.i; A.478.b.4.i; A.479.b.4.i; A.480 .b.4.i; A.4Sl.b.4.i; A.482.b.4.i; A.483.b.4.i; A.484.b.4.i; A.485 .b.4.i; A.486.b.4.i; A.487.b.4.i; A.488.b.4.i; A.489.b.4.i; A.49 〇.b.4.i; A.491.b.4.i; A.492.b.4.i; A.493.b.4.i; A.494.b.4.i; A. 495.b.4.i; A.496.b.4.i; A.497.b.4.i; A.498.b.4.i; A.499.b.4.i; A. 500.b.4.i; A.501.b.4.i; A.502.b.4.i; A.503.b.4.i; A.504.b.4.i; A. 505.b.4.i; A.506.b.4.i; A.507.b.4.i; A.508.b.4.i; A.509.b.4.i; A. 510.b.4.i; A.511.b.4.i; A.512.b.4.i; A.512.b.4.i; A.513.b.4.i; A. 514.b.4.i; A.515.b.4.i; A.516.bAi; A.517.b.4.i; A.518.b.4.i; A.519.b. 4.i; A.520.b .4.i; A.521.b.4.i; A.522.b.4.i; A.523.b.4.i; A.524.b.4.i; A.525.b .4.i; A.526.b.4.i; A.527.b.4.i; A.528.b.4.i; A.529.b.4.i; A.530.b .4.i; A.531.b.4.i; A.532.b.4.i; A.533.b.4.i; A.534.b, 4.i; A.535.b .4.i; A.536.b.4.i; A.537.b.4.i; A.538.b.4.i; A.539.b.4.i; A.540.b .4.i; A.541.b.4.i; A.542.b.4.i; A.543.b.4.i; A.544.b.4.i; A.545.b .4.i; A; 546.b.4.i; A.547.b.4.i; A.548.b.4.i; A.549.b.4.i; A.550.b .4.i; A.551.b.4.i; A.552.b.4.i; A.553.b.4.i; A.554.b.4.i; A.555.b .4.i; A.556.b.4.i; A.557.b.4.i; A.558.b.4.i; A.559.b.4.i; A.560.b .4.i; A.561.b.4.i; A.562.b.4.i; A.563.b.4.i; A.564.b.4.i; A.565.b .4.i; A.566.b.4.i; A.567.b.4.i; A.568.b.4.i; A.569.b.4.i; A.570.b .4.i; A.571.b.4.i; A.572.b.4.i; A.573.b.4.i; A.574.b.4.i; A.575.b .4.i; A.576.b.4.i; A.577.b.4.i; A.578.b.4.i; A, 579.b.4.i; A.580.b .4.i; A.581.b.4.i; A.582.b.4.i; A.583.b.4.i; A.584.b.4.i; A.585.b .4.i; A.586.b.4.i; A.587.b.4.i; A.588.b.4.i; A.589.b.4.i; A.590.b .4.i; A.591.b.4.i; A.592.b.4.i; A.593.b.4.i; A.594.b.4.i; A.595.b .4.i; A.596.b.4 .i; A.597.b.4.i; A.598.b.4.i; A.599.b.4.i; A.600.b.4.i; A.601.b.4 .i; A.602.b.4.i; A.603.b.4.i; A.604.b.4.i; A.605.b.4.i; A.606.b.4 .i; A.607.b.4.i; A.608.b.4.i; A.609.b.4.i; A.610.b.4.i; A.611.b.4 .i; A.612.b.4.i; A.613.b.4.i; A.614.b.4.i; A.615.b.4.i; A.616.b.4 .i; A.617.b.4.i; A.618.b.4.i; A.619.b.4.i; A.620.b.4.i; A.621.b.4 .i; A.622.b.4.i; A.623.b.4.i; A.624.b.4.i; A.625.b.4.i; A.626.b.4 .i; A.627.b.4.i; A.628.b.4.i; A.629.b.4.i; A.63〇.b.4.i; A.631.b. 4.i; A.632.b.4.i; A.633.b.4.i; A.634.b.4a; A.635.b.4.i; A.636.b.4. i; A.637.b.4.i; A.638.b.4.i; A.639.b.4.i; A.640.b.4.i; A.641, b.4. i; A.642.b.4.i; A.643.b.4.i; A.644.b.4.i; A.645.b.4.i; A.646.b.4. i; A.647.b.4.i; A.648.b.4.i; A.649.b.4.i; A.650.b.4.i; A.651.b.4. i; A.652.b.4.i; A.653.b.4.i; A.654.b.4.i; A.655.b.4.i; A.656.b.4. i; A.657.b.4.i; A.65S.b.4.i; A.659.b.4.i; A.660.b.4.i; A.2.b.ll. i; ASbll.i; A.4.b.lU; A.5.b.ll.i; A.6.b.ll.i; AJ.b.ll.i; A.9.b.ll .i; A.IO.b.ll.i; A.15.b.ll.i; A.IOO.b.ll.i; A.IOl.b.ll.i; A.IOlb.ll.i ; A.103.b.ll.i; A.104.b.ll.i; A.105.b.ll.i; A.106.b.ll.i; A.107.b.ll.i; A.108.b.ll.i; A.109.b.ll.i; A.llO.b.ll.i; A.lll.b.ll.i; A.112.b.ll.i; A.113.b.ll.i; A.114.b.ll.i; A.116.b.ll.i; A.llS.b.ll.i; A.119.b.ll.i; 15 20 25 30 35 45 This paper is a standard in the national standard (CNS) / \ 4, sigh (210X 2 () 7 male f) -143-Please read the back first

I's Note

Page order 4266 6 3, V. Description of the invention (A7 B7 141, printed by the Consumers' Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs A.120.b.ll.i; A.121.b.ll.i; A.122. b.ll.i; A.123.b.ll.i; A.124.b.ll.i; A.125.b.ll.i; A.126.bUi; A.127.b.ll. i; A.12S.b.ll.i; A.129.b.ll.i; A.130.b.ll.i; A.131.b.ll.i; A.132.b.ll. i; A.133.b.ll.i; A.134.bUi; A.135.b.ll.i; A.136.b.ll.i; A.137.b.ll.i; A. 138.b.ll.i; A.139.b.ll.i; A.14〇.b.ll.i; A.141.b.ll.i; A.142.b.ll.i; A .143.b.ll.i; 5 A.144.b.ll.i; A.145.b.ll.i; A.146.b.ll.i; A.147.b.ll.i; A.148.b.ll.i; A.149.b.ll.i; A.150.b.ll.i; A.151.b.ll.i; A.l52.b.ll.i; A.153.b.ll.i; A.154.b.ll.i; A.155.b.ll.i; A.156.b.ll.i; A.157.b.ll.i; A.158.b.ll.i; A.159.b.ll.i; A.160.b.ll.i; A.161.b.ll.i; A.162.b.ll.i; A.l63.b.ll.i; A.164.b.ll.i; A.165.b.ll.i; A.166.b.ll.i; A.167.b.ll.i; A.168.b.ll.i; A.169.b.ll.i; A.170.b.ll.i; A.171.b.ll.i; A.172.b.ll.i; A.173.b.ll.i; 10 A.174.b.ll.i; A.175.b.ll.i; A.176.bUi; A.177.b.ll.i; A.178 .b.ll.i; A.179.b.ll.I; A.180.b.ll.i; A.181.b.ll.i; A.182.b.ll.i; A. 183.b.ll.i; A.184.b.ll.i; A.185.b.ll.i; A.186.b.ll.i; A.187.b.lli; A.188. b.ll.i; A.189.b.ll.i; A.X90.b.ll.i; A.191.b.ll.i; A.192.b.ll.i; A.193. b.ll.i; A.194.b.ll.i; A.195.b.ll.i; A.196.b.ll.i; A.197.b.ll.i; A.198. b.ll.i; A.199.b.ll.i; A.200.b.ll.i; A.201.b.ll.i; A.202.b.ll.i; A.203. b.ll.i; 15 A.204.b.ll.i; A.205.b.ll.i; A.206.b.ll.i; A.207.b.ll.i; A.208 .b.ll.i; A.209.b.ll.i; A.210.b.ll.i; A.211.b.ll.i; A.212.b.ll.i; A.213 .b.ll.i; A.214.b.ll.i; A.215.b.ll.i; A.216.b.ll.i; A.217.b.ll.i; A.21S .b.ll.i; A.219.b.ll.i; A.220.b.ll.i; A.221.b.ll.i; A.222.b.ll.i; A.223 .b.ll.i; A.224.b.ll.i; A.225.b.ll.i; A.226.b.ll.i; A.227.b.ll.i; A.228 .b.ll.i; A.229.b.ll.i; A.230.b.ll.i; A.231.b.ll.i; A.232.b.ll.i; A.233 .b.ll.i; 20 A.234.b.ll.i; A.235.b.ll.i; A.236.bUi; A.237, b.ll.i; A.238.b. ll.i; A.239.b.ll.i; A.240.b.ll.i; A.241.b.ll.i; A.242.b.ll.i; A.243.b. ll.i; A.244.b.ll.i; A.245.b.ll.i; A.246.b.ll.i; A.247.b.ll.i; A.248.b. ll.i; A.249.b.ll.i; A.250.b.ll.i; A.251.b.ll.i; A.252.b.ll.i; A.25 3.b.ll.i; A.254.b.ll.i; A.255.b.ll.i; A.256.b.ll.i; A.257.b.ll.i; A. 258.b.lLi; A.259.b.ll.i; A.260.b.ll.i; A.261.b.ll.i; A.262.b.ll.i; A.263. b.ll.i; 25 A.264.b.ll.i; A.265.b.ll.i; A.266.b.ll.i; A.267.b.ll.i; A.268 .b.ll.i; A.269.b.ll.i; A.270.b.ll.i; A.271.b.ll.i; A.272.b.ll.i; A.273 .b.ll.i; A.274.b.ll.i; A.275.b.ll.i; A.276.b.ll.i; A.277.b.ll.i; A.278 .b.ll.i; A.279.b.ll.i; A.280.b.lU; A.281.b.ll.i; A.282.b.ll.i; A.283.b .ll.i; A.284.b.ll.i; A.285.b.ll.i; A.286.b.ll.i; A.287.b.ll.i; A.288.b .ll.i; A.289.b.ll.i; A.290.b.ll.i; A.291.b.ll.i; A.292.b.ll.i; A.293, b .ll.i; 30 A.294.b.ll.i; A.295.b.ll.i; A.296.b.ll.i; A.297.b.ll.i; A.298. b.ll.i; A.299.b.ll.i; A300.b.ll.i; A.301.b.ll.i; A.302.b.ll.i; A.303.b. ll.i; A.304.bHi; A.305.b.ll.i; A.306.b.ll.i; A.307.b.ll.i; A.308.b.ll.i; A.309.b.ll.i; A.310.b.ll.i; A.311.b.ll.i; A.312.b.ll.i; A.313.b.ll.i; A.314.b.ll.i; A.315.b.ll.i; A.316.b.ll.i; A.317.b.ll.i; A.318.b.ll.i; A.319.b.ll.i; A.320.b.ll.i; A.321.b.ll.i; A.323.b.ll.i; A.324.bl li; 35 A.325.b.ll.i; A.326.b.ll.i; A.327.b.ll.i; A.328.b.ll.i; A.329.b.ll .i; A.330.b.ll.i; A.331.b.ll.i; A.332.b.ll.i; A.333.b.ll.i; A.334.b.ll .i; A.335.b.ll.i; A.336.b.ll.i; A.337.b.ll.i; A.338.b.ll.i; A.339.b.ll .i; A.340.b.ll.i; A.341.b.ll.i; A.342.b.ll.i; A.343.b.ll.i; A.344.b.ll .i; A.345.b.ll.i; A.346.b.lU; A.347.b.ll.i; A.34S.b.ll.i; A.349.b.ll.i ; A.350.b.ll.i; A.351.b.ll.i; A.352.b.lU; A.353.b.ll.i; A.354.b.ll.i; 40 A.355.b.ll.i; A.356.b.ll.i; A.357.b.ll.i; A.358.b.ll.i; A.359.b.ll.i; A.360.b.ll.i; A.361.b.ll.i; A.362.b.ll.i; A.363.b.ll.i; A.364.b.ll.i; A.365.b.lli; A.366.b.Il.i; A.367.b.ll.i; A.368.b.ll.i; A.369.b.ll.i; A. 370.b.ll.i; A.371.b.ll.i; A.372.b.ll.i; A.373.b.ll.i; A.374.b.ll.i; A. 375.b.ll.i; A.376.b.ll.i; A.377.b.ll.i; A.378.b.ll.i; A.379.b.ll.i; A. 380.b.ll.i; A.381.b.ll.i; A.382.b.ll.i; A.383.b.ll.i; A.384.b.ll.i; 45 A .385.b.ll.i; A.386.b.ll.i; A.387.b.ll.i; A.388.b.ll.i; A.389.b.ll.i; A .390.b.ll.i; A.391.b.ll.i; A.392.b.ll.i; A.393.b.ll.i; A.394.b.ll.i; A .395.b.ll.i; A.396.b.ll.i; A.397.b.ll.i; A.398.b.ll.i; A.399.bUi; A.400.b .ll.i; A.401.b.ll.i; A.402.b.ll.i; A.403.b.ll.i; A.404.b.ll.i; A.405.b .ll.i; A.4Q6, b.ll.i; A.407, b.ll.i; A.408.b.ll.i; Please read the note of © first

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A.409.b.ll.i; A.410.b.ll.i; A.411.b.ll.i; A.412.b .ll.i; A.413.b.ll.i; A.414.b.ll.i; A.415.b.ll.i; A.416.b.ll.i; A.417.b .ll.i; A.418.b.ll.i; A.419.b.ll.i; A.420.b.ll.i; A.421.b.ll.i; A.422.b .ll.i; A.423.b.ll.i; A.424.b.ll.i; A.425.b.ll.i; A.426.b.ll; i; A.427.b .ll.i; A.428.b.ll.i; A.429.bUi; A.43〇.b.ll.i; A.431.b.ll.i; A.432.b.ll. i; 5 A.433.b.ll.i; A.434.b.ll.i; A.435.b.ll.i; A.436.b.ll.i; A.437.b.ll .i; A.438.b.ll.i; A.439.b.ll.i; A.440.b.ll.i; A.441.b.ll.i; A.442.b.ll .i; A.443.b.ll.i; A.444.b.ll.i; A.445.b.ll.i; A.446.b.ll.i; A.447.b.ll .i; A.448.b.ll.i; A.449.b.ll.i; A.450.b.ll.i; A.451.b.ll.i; A.452.b.ll .i; A.453.b.ll.i; A.454.b.ll.i; A.455.b.ll.i; A.456.b.ll.i; A.457.b.ll .i; A.458.b.ll.i; A.459.b.ll.i; A.460.b.ll.i; A.461.bUi; A.462.b.ll.i; 10 A.463.b.ll.i; A.464.b.ll.i; A.465.b.ll.i; A.466.b.ll.i; A.467.b.ll.i; A.468.b.ll.i; A.469.b.ll.i; A.470.b.ll.i; A.471.b.ll.i; A.472.b.ll.i; A.473.b.ll.i; A.474.b.ll.i; A.475.b.ll.i; A.476. b.ll.i; A.477.b.ll.i; A.478.b.lU; 'A.479.b.ll.i; A.480.b.ll.i; A.481.b .ll.i; A.482.b.ll.i; A.483.b.ll.i; A.484.b, ll.i; A, 485.b.lX.i; A.486.b .ll.i; A.487.bUi; A.488.b.ll.i; A.489.b.ll.i; A.490.b.ll.i; A.491.b.ll.i ; A.492.b.ll.i; 15 A.493.b.ll.i; A.494.b.ll.i; A.495.bHi; A.496.b.ll.i; A. 497.b.ll.i; A.498.b.ll.i; A.499.b.ll.i; A.500.b.ll.i; A.SOl.b.ll.i; A. 502.b.ll.i; A.503.b.ll.i; A.504.b.ll.i; A.505.b.ll.i; A.506.b.ll.i; A. 507.b.ll.i; A.508.b.ll.i; A.509.b.ll.i; A.SlO.b.ll.i; A, 511.b.ll.i; A. 512.b.ll.i; A.512.b.ll.i; A.513.b.ll.i; A.514.b.ll.i; A.515.b.ll.i; A. 516.b.ll.i; A.517.b.ll.i; A.518.b.ll.i; A.519.b.ll.i; A.520.b.ll.i; A. 521.b.ll.i; 20 A.522.b.ll.i; A.523.b.ll.i; A.524.b.ll.i; A.525.b.ll.i; A .526.b.ll.i; 'A.527.b.ll.i; A.528.b.ll.i; A.529.b.ll.i; A.530.b.ll.i; A.531.b.ll.i; A.532.b.ll, i; A.533.b.ll.i; A.534.b.ll.i; A.535.b.ll.i; A.536.b.ll.i; A.537.bUi; A.538.b.ll.i; A.539.b.ll.i; A.540.b.ll.i; A.541. b.ll.i; A.542.b.ll.i; A.543.b.ll.i; A.544.b.ll.i; A.545.b.ll.i; A.546. b.ll .i; A.547.b.ll.i; A.548.b.ll.i; A.549.b.ll.i; A.550.b.ll.i; A.551.b.ll .i; 25 A.552.b.ll.i; A.553.b.ll.i; A.554.b.ll.i; A.555.b.ll.i; A.556.b. ll.i; A.557.b.ll.i; A.558.b.ll.i; A.559.b.ll.i; A.560.b.ll.i; A.561.b. ll.i; A.562.b.ll.i; A.563.b.ll.i; A.564.b.ll.i; A.565.b.ll.i; A.566.b. ll.i; A.567.b.ll.i; A.568.b.ll.i; A.569.b.ll.i; A.570.b.ll.i; A.571.b. ll.i; A.572.b.ll.i; A.573.b.ll.i; A.574.b.ll.i; A.575.b.ll.i; A.576.b. ll.i; A.577.b.ll.i; A.578.b.ll.i; A.579.b.ll.i; A.580.b.ll.i; A.581.b. ll.i; 30 A.582.b.ll.i; A.583.b.ll.i; A.584.b.ll.i; A.585.b.ll.i; A.586.b .ll.i; A.587.b.ll.i; A.588.b.ll.i; A.589.b.ll.i; A.590.b.ll.i; A.591.b .ll.i; A.592.b.ll.i; A.593.b.ll.i; A.594.b.ll.i; A.595.b.ll.i; A.596.b .ll.i; A.597.b.ll.i; A.598.b.ll.i; A.599.b.ll.i; A.600.b.ll.i; A.601.b .ll.i; A.602.b.ll.i; A.603.bUi; A.604.b.ll.i; A.605.b.ll.i; A.606.b.ll.i ; A.6〇7.b.ll.i; A.608.b.ll.i; A.609.b.ll.i; A.610.b.ll.i; A.611.b.ll .i; 35 A.612.b.ll.i; A.613.b.ll.i; A.614.b.ll.i; A.615.b.ll.i; A.616.b. ll .i; A.617.b.ll.i; printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs A.618.b.ll.i; A.619.b.ll.i; A.620.b.lU ; A.621.b.ll.i; A.622.b.ll.i; A.623.b.ll.i; A.624.b.ll.i; A.625.b.ll.i ; A.626.b.ll.i; A.627.b.ll.i; A.628.b.ll.i; A.629.b.ll.i; A.630.b.ll.i ; A.631.b.ll.i; A.632.b.lU; A.633.b.ll.i; A.634.b.ll.i; A.635.b.ll.i; A .636.b.ll.i; A.637.b.ll.i; A.638.b.ll.i; A.639.b.ll.i; A.640.b.ll.i; A .641.b.ll.i; 40 A.642.b.ll.i; A.643.b.ll.i; A.644.b.ll.i; A.645.b.ll.i; A.646.b.ll.i; A.647.b.ll.i; A.648.b.ll.i; A.649.b.ll.i; A.650.b.ll.i; A.651.b.ll.i; A.652.b.ll.i; A.653.b.ll.i; A.654.b.ll.i; A.655.b.ll.i; A.656.b.ll.i; A.657.b.ll.i; A.658.b.ll.i; A.659.b.ll.i; A.66〇.b.ll.i ; A.2.x.4.i; A.3.x.4.i; A.4.x.4.i; A.5.x.4.i; A.6.x.4.i ; A.7.x.4.i; A.9.x.4.i; Al〇.x.4.i; A.15.x.4i; A.10〇.x.4.i; A. .101.x.4.i; A.102.x.4.i; A.103.x.4.i; A.104.x.4.i; 45 Α.105.Χ.4.Ϊ; A.106.x.4.i; A.107.x.4.i; A.108.x, 4.i; A.109.x.4.i; A.110.x.4.i; A.lll.x.4.i; A.112.x.4.i; A.113.x.4.i; A.114.x; 4.i; A.115.x.4. i; Α.116.χ.4 · ί; A.117.x.4.i; A.llS.x.4.1; A.119.x.4.i; Α.120.χ.4.Ϊ; Amx4.i; A.122.x.4.i; A.123.x.4.i; A.124.x.4.i; A.125.x.4.i; A.126.x .4.i; A.127.x.4.i; A.128.x.4.i; A.129.x.4.i; A.130.x.4.i; A.131.x .4.i; A.l32.x.4.i; This paper size applies to Chinese National Standard (CNS) Λ4 Dange (210x20 male thin) Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs 4 266 6 3 A7 * B7_____ _V. Description of the invention (143) A.133.x.4, i; A.134.x.4.i; A, 135.x, 4a; A.136.x.4, i; Α.137. Χ.4Λ; Α.138α.4Λ; Α.139.χ.4Λ; A.140.x.4.i; A.141.x.4.i; A.142.x.4.i; A. 143.x.4.i; A.144.x.4.i; A.145, x.4.i; A.146.x.4.i; ΑΛ47.χΑΛ; ΑΛ48.χΛΛ; A.149. x.4.i; A.150-X.4.1; A.151.x * 4.i; A.152 * xAi; A.153.x.4.i; A.154.X.4J; A. 155-xAi; A.156.x.4.i; ΑΛ57.χΑΛ; A.158.x.4.i; A.159.x.4.i; A.160.x.4.i; 5 A .161.X.4.1; A.162.x.4.i; A.163.x.4.i; A.164.x.4i; A.165.x.4.i; A.166.x .4.i; ΑΛ67, χΛΛ; ΑΛ68.χΑλ; A.169.x.4.i; Α.170.χ.4Λ; A.171.x.4.i; A, 172 * x.4.i ; A.173.xAi; A.174x, 4.i; ΑΛ75.χ.4.ί; A.176, x.4i; Λ77.χ, 4.ι; A, 178.x.4.i; A.179.x.4.i; A.180.x &gt;4.i;A.181.x.4.i; A. 182.x.4.i; A.lS3.x, 4i; ΑΛ84.χ.4Λ; A, 185.x.4.i; ΑΛ86.χ.4.1; A187.x, 4.i; A-188, x.44i; A.189.x.4.i; A.190.x.4.i; A.191.x.4.i; A.192, x.4i; A.193, x, 4. i; A.194.x.4.i; A, 195.x, 4.i; 10 A.196, x.4.i; Α.197.χ.4Λ; A198.x.4.i; A .199.x.4.i; A, 200.x.4i; A.201.x, 4.i; A.202.x.4, i; Α203.χ · 4 · ί; Α · 204 · Χ · 4 · ί; A.205.x, 4.i; Α · 206'χ.4 · ί; A.207.x, 4, i; A, 208'x.4.i; Α. · 209 · χ.4 · ί; A.210.x.4, i; A.211.x.4.i; A.212.x.4, i; A, 213.x * 4i; A.214, x.4.i; A.215.x.4.i; A.216.x.4.i; A-217.x.4.i; Α · 218 · χ * 4.ί; Α · 219_χ · 4 · ί; Α · 220 · χ · 4 · ί; A.221.x, 4.i; Α · 222 · χ.4 · ί; Α.223 · χ.4 · ί; A.224.x, 4.i; Α.225.χ.4.1; Α.226.χ.4 j; Α227, χΛλ; Α.228.χΛλ; Α229.χΑλ; A, 23〇.x, 4.i; 15 A.231 .x.4i; A.232, x, 4.i; A.233.x.4.i; A.234.x, 4.i; A, 235.xAi; A-236, x.4.i ; Α.237.Χ.4.Ϊ; Α-238.Χ.4.Ϊ; A.239.x, 4.i; A, 240.x.4.i; A, 241.x.4.i ; A.242.x, 4, I; A, 243.x.4.i; A.244.x.4.i; A.245.x.4.i; Α.246.Χ.4Λ ; Α.247.χ, 4λ; A.248.x.4a; A.249.x, 4.i; A, 250.x.4.i; A.251, xAi; A.252, x, 4 , i; A.253.x, 4.i; A254, x, 4.i; A.255.x.4.i; A, 256.x.4.i; A.257, x.4.i ; A.258.x.4.i; A.259.x.4.i; A.260, x.4.i; A.261.x.4i; A, 262.x.4i; A.263 .x.4.i; A.264.x.4.i; Α.265.χ.4Λ; 20 A.266.x.4.i; A.267.x.4.i; A.268. x * 4, i; A * 269.x.4.i; A.270.x.4.i; A.271.x.4 * i; Α272.χΛΛ; A * 273.x.4, i; A, 274.x, 4.i; Α275.ΚΑΛ; A.276.x.4.i; A.277.x.4.i; A.278.x.4.i; A.279, x. 4.i; A.280.x.4, i; A.28Lx.4-i; Α.282.χ.4.Ϊ; A.283.x.4.i; A.284.x.4. i; A.285.x.4.i; A.286.x.4.i; Α.287.χΛλ; A.288.x, 4.i; A, 289.x.4.i; A. 290.x.4.i; A.291.x.4.i; A, 292.xAi; A.293.x.4 * i; A.294.X.4.1; A, 295, x.4. i; Α.296.χΛ.ΐ; A.297.xAi; A.298, x.4.i; A.299.x.4.i; A.300, x.4.i; 25 A.301 * x, 4.i; A.302.x.4.i; A.303.x.4.i; A.304 * x, 4.i; A, 305.x.4.i; A.306 .x.4, i; A.307.x.4.i; A.308.xAi; Α.309.χ.4.Ϊ; A, 310.x.4.i; A, 311.x.4 , i; A.312.x.4.i; A, 313.x.4.i; A314.x.4i; A.315.x.4.i; A.316.x, 4.i; A , 317.x.4, i; A.318.x * 4.i; A.319, x.4.i; Α320.χ.4Λ; A, 32Lx.4.i; A.323, x.4 .i ; A.324.x.4.i; A.325.x.4 * i; A.326, x.4.i; A.327.x, 4.i; A.328, x, 4.i ; A.329.x * 4.i; A, 330-x.4.i; A33Lx.4.i; A.332, x.4.i; A.333.x.4.i; A.334 .x.4.i; A.335.x, 4.i; A.336.xAi; 30 A, 337'x + 4.i; A.338.x, 4_i; A · 339.χ · 4. ί; Α · 340 · χ, 4 · ί; A * 341.x'4.i; Α · 342.χ · 4 · ί; A_343 * x'4.i; Α344.χ.4.Ϊ; A345. x.4, i; A346.x.4, i; A.347.x.4i; A.348.x.4.i; A.349.x.4.i; A, 350.x.4. i; A.351 * x.4.i; A, 352 * x.4, i; A.353 * x.4, i; A.354.x.4.i; A.355.x, 4. i; A * 356-x.4.i; A.357.x, 4.i; Α · 358 · χ · 4 ″; Α · 359 · χ · 4 · ϋ; Α · 360.χ · 4 · ί Α · 361 ， χ · 4Λ; Α362-χ, 4 · ί; A.363.x.4.i; A-364, x.4.i; Α.365-χ.4.Ϊ; A * 366.x.4.i; A.367.x.4.i; A.368.x.4i; A.369.x.4.i; A.37〇.x.4.i; A. 371.x_4.i; 35 A.372.x, 4, i; A.373.x.4.i; A.374.x.4.i; A.375_x.4.i; A.376.x * 4i; A.377.x.4.i; A.378.x.4i; Α379.χΛΛ; A.38〇.x.4.i; A.381.x.4, i; A.382. x.4.i; Α.383.Χ.4Λ; A.384.x.4, i; Α.385.Χ.4Λ; A.386.x.4 * i; A.387.x.4. i; A.388.x.4, i; A.389.x.4.i; A.390.x.4.i; A.391.x.4.i; A.392.x.4. i; A.393.x.4.i; A.394.x.4, i; A.39 5.x.4.i; A.396.x.4.i; A.397.x.4.i; A.398.x.4.i; A.399.x.4.i; A. 400.x.4.i; A, 401.x, 4.i; A.402.x.4.i; A.403.x.4.i; A.404.x.4.i; A. 405.x.4.i; A.406.x * 4.i; 40 Α.40λχ.4, ι; A.408, xAi; A.409.x.4j; A.410, x.4, i ; A.411.x.4i; A.412.x.4.i; A, 413.x.4.i; A.414.x.4j; A.4l5.x.4.i; A.416 .x.4i; A.417, x.4.i; A.418.x.4.i; A.419, x.4.i; A.420.x.4.i; A.421.x .4i; A.422.x.4, i; A.423.x.4.i; A.424.x.4, i; A, 425.x.4, i; A.426.x, 4 .i; A.427, x.4.i; A.428.x.4.i; A.429, x.4.i; A.430.x.4.i; A, 431.x.4 .i; A, 432.x.4j; A.433.x.4.i; A.434.x.4.i; A, 435.x.4.i; Α.436.AX.4Λ; A .437, x.4.i; A.438.x.4.i; A.439.x.4, i; A.44〇.x.4.i; A.441.x.4.i; 45 A.442.x.4.i; A.443.x.4 &gt;i; A * 444.x.4.i; A.445.x.4.i; Α.446.AX.4Λ; A , 447.x.4.i; A.448.x.4.i; A, 449.x.4.i; A.450.X.4J; A.451.x.4.i; A.452 .x, 4.i; A.453.x.4.i; A, 454.x.4.i; A.455 * x.4.i; A, 456.x.4, i; A.457 .x.4.i; A, 458.x.4.i; A.459, x, 4, i; A, 460, x, 4.i; A.46Lx.4.i; A.462.x .4.i; A.463, x.4.i; A.464, x.4.i; A.465.x, 4.i; A.466.x.4.i; A.467.x .4.i; A.468.x.4.i; A.469.x, 4.i; this titanium sheet Standards are in accordance with Chinese National Standards (CNS) / \ 4 specifications (210X 297 public broadcasting). _ First, please read the precautions before selling, and then order) line 426663 ^ V. Description of the invention (14now Α.470.Χ.4Λ; Α.471.χ, 4.ί; ΑΛ72, χ.4λ; Α.473.χ.4Λ; A.474x, 4.i; A, 475.x.4.i; Α, 476.χ.4. ί A.477.x.4.i; ΑΛ78.χΛΛ; A-479.x, 4.i; A.4S0.x.4i; A, 481.x.4.i; A.482.x.4 .i; A.483.x.4, i A, 484.x.4.i; ΑΑ85, χΛΛ; AA86.xA.i; AA87.xA.i; A, 488.x.4.i; A, 489.x.4.i; A.49〇.x.4.i A.491.X.4.1; A.492.x.4, i; A.493.x.4.i; A.494, x.4.i; A, 495.x.4i; A.496.x.4i; A.497, x.4i 5 A.498.X.4.i; A.499.x.4a; A. 500.x.4.i; A.501 * x.4.i; A.502, x.4i; A.503, x, 4.i; A.504.X.4 j A.505.x. 4.i; Α.506.Χ.4-Ϊ; A.507.x.4.i; A.508.x.4a; A.509.x.4.i; A.510.x.4. i; A.511.x.4j A.512.x.4.i; A.512.X.4.1; A.513.x.4.i; A.514.x.4.i; A.515 .x.4.i; A.516.x_4.i; A-517.x.4i A.518.x.4.i; Α.519.Χ.4.Ϊ; A.520.x.4. i; A.521.x.4.i; A.522, x.4.i; A.523.x.4.i; A.524.x.4j, A.525.x.4.i; A * 526.x.4.i; A.527, x.4.i; A.528.x.4.i; A, 529.xAi; A.530.x.4i; A.531.x. 4.i 10 Α.532.Χ .4Λ; A.533.x.4.i; A, 534.x.4.i; A.535.x.4_i; A.536.x.4.i; A.537.x.4.i ; A.538.x.4.i Α539 · χ · 4Λ; A.540.x.4.i; A.541.x.4.i; Α.542 · χ · 4 · ί; A. 543.xAi; A.544i4.i; A.545.x.4.i A.546.x.4, i; A.547.x.4i; A * 548.x.4.i; A.549 .x.4.i; A.550 * x.4.i; A.551.x.4.i; A.552.x.4, i A, 553.x.4.i; A.554. x.4i; A.555.x.4.i; A.556 * x.4.i; A.557.x.4.i; A.558.x.4.i; Α.559.χ. 4Λ A * 560.x.4 * i; A.561.x.4.i; A.562.x.4.i; A.563.x.4, i; A * 564.x.4i; A .565.x.4.i; A.566.x.4.i 15 Α.567, χ.4 · ί; Α.568.χ.4 · ί; A.569.x.4.i; A .570.xAi; A.571.x.4.i; A * 572.x.4, i; A.573.xAi A.574.x * 4.i; A.575.x-4, i; A.576.X.4, i; A.577.x.4.i; A.578.x.4, i; A.579.x.4.i; A.580.x.4-i A .581.x.4 * i; A.5S2.x.4_i; A.583.x.4.i; A.584.x.4, i; A_585.x.4.i; A.586.x .4.i; A.587.x.4.i A.588; x.4.i; A.589.x.4.i; A, 590.x.4.i; A.591.x. 4.i; A.592.x.4.i; A.593.x.4.i; A.594, x.4.i A.595.x.4.i; A.596.x.4 .i; A * 597.x.4J; A.598.x.4i; A.599.x.4.i; A.600.x.4j; A.601.x.4.i 20 A.602 .x.4.i; A.603.x.4.i; A.604, x.4.i; A.605.x.4.i; A, 606.x.4.i; A.607 .x.4.i; A.608.x.4_i A. 609.x.4.i; A.610.X.4.1; A.61Lx, 4.i; A_612.x.4i; A.6l3.x.4.i; A.614.x.4.i; A.615.x.4.i Α.616.Χ.4Λ; A.617, x.4.i; A * 618.x.4.i; A.619.x.4i; A.620.x , 4.i; Α.621.AX.4Λ; A.622.x.4, i A.623.x.4.i; Α.624.AX.4Λ; A.625.x.4i; A. 626.xAi; A.627 * x.4.i; A.628.x.4.i; A * 629.x.4.i A, 630.x.4.i; A.631 乂 4.i ; A.632.xAi; A, 633.x-4, i; A-634.x.4.i; A.635.x.4.i; A.636.x.4.i 25 A.637_x , 4.i; Α · 638.χ, 4 · ί; Α · 639 + χ · 4.ί; A.640_x.4.i; Α · 641 jc.4.i; Α · 642 · χ · 4. ί; A.643.x.4, i Α · 644 · χ.4_ί; A.645.x, 4.i; Α · 646_χ · 4-ί; Α · 647 · χ.4.ί; Α.648 · Χ · 4 j; Α · 649.χ · 4-ί; Α, 650 · χ · 4Λ A.651.x.4.i; A.652.x.4_i; Α.653 · χ.4 · ί ; Α.654.Χ.4 ×-Α-655.χ · 4 · ί; A_656.x_4.i; Α · 657 · χ · 4 * ί Α.658.χ.4.ί; A.659.x. 4.i; A, 660 * x, 4.i; A.2.x.lli; A.3.x, ll.i; A.4.x.ll.i; A.5.xJl.i; Α.6 · χ.11 ， ί; Α, 7 · χ, 11, ί; Α · 9.χ · 11 · ί; A.lO.x.ll.i, · A, 15.x.ll.i ; A.IOO.x.lli; Α · 101 · χ · 11.ί; 30 A.102.x.ll, i; ΑΛ03, χ.11.ί; A.104.X.1U; A.105. x.ll.i; A.106.x.ll.i; A.107.X.1U; Α.108.Χ.1Π; Α. 109.X.11.1; A.llO.x.ll.i; A.111.X.1U; AJ12.x.lLi; A.113.X.1U; ΑΛΓ4.χ.11.ί; A.115. x.lU; A.116.X.1U; A.117.x.ll.i; A.118.x.ll.i; A.119.x.ll.i; A.120, x.ll. i; A, 12Lx.ll.i; A.122.X.1U; A.123.x.ll.i; A.124.x.ll.i; A.125.X.1U; A.126. X.1U; Α.127.Χ.1Π; ΑΛ28.Χ.11.Ϊ; A.129.X.1U; A130.x.ll.i; A.131.x.lli; 35 A.132.x .ll.i; A.133.x.lla; A, 134.x.ll.i; A.135.x, ll.i; A136.x.ll.i; A.137.X.1U; Economy Printed by the Central Bureau of Standards of the People's Republic of China, A.138.x.lLi; A.139.x.ll.i; A.140.x.lli; A.141.x-ll.i; A.142 .xll.i; A143.X.1U; A, 144.x.lLi; A.145.x * ll.i; A.146.x, ll.i; A.147.x.ll.i; A .148.x.ll.i; AJ49, x.lli; Α · 150.χ · 11 · ί; Α, 151 · χ.11 · ί; Α.152 · χ · 11 j; Α.153 · χ · 11.ί; Α · 154.χ · 11.ί; Α · 155.χ, 11 · ί; A.156.x.ll.i; A.15Zx.ll.i; A.158.x.ll. i; ΑΛ59.χΛ1Λ; A.160-x.ll.i; A.16Lx.ll.i; 40 A.162.x.lLi; A.163.x.ll.i; A.164.x.ll .i; Α.165, χ.1Π; A.166.x.lLi; A.167.x.ll.i; Α.168.χ.Π.Ϊ; A.169.X.1U; A.170 .X.1U; A.lZl.x.ll.i; A.172.x.ll.i; A.173.x.ll.i; Α · 174 · χ · 11 ; A.175.x.ll.i; A.176.X.1U; A.177.x.ll-i; A.17S.x.ll.i; Α · 179 · χ · 11 · ί; A .180.X.1U; A.1S1.X.1U; A.182.x.ll.i; A.183.x.lLi; AJ84.x.ll.i; A.185.x.ll.i ΑΛ86, χΛ1λ; Α.187.χ.11.Ϊ; A.lS8.x, ll.i; A.189.X.1U; A.190.x.ll.i; A.191.x.lLi 45 A.192.x.ll.i; AJ93.x.ll.i; ΑΛ94.χ.1Π; ΑΛ95.χ.Π.1; A.196.x.ll.i; A.197.x. ll.i; ΑΛ98-χ.1Π; ΑΛ99.χ.11.ί; A.200.x.ll.i; Α.201-χ.11Λ; A.202.xll.i; A203.x.ll. i; A.2〇4.x-ll.i; A.205.x.ll.i; A.206.χΛ1.ι; A-207.x.ll.i; A.208.x.Il. i; Α.209.AX.ΠΛ; A.210.x.ll.i; A.212.x, ll, i; A.213.xHi; Α.214.χ.1Ιά; Α.215.AX. 11Λ; The size of this paper is applicable to the standard of the Chinese standard house (CNS) Λ4 (2 丨 ϋ X m public expense) -147 — 4 2 6 6 6 3 / A7 B7 V. Description of the invention (145) A.216.x. ll.i; Α.217.Χ.Π.Χ; A.2lS.x.ll.i; A.219.xUi; A.220.x.ll.i; A.221.x.ll.i; A.222.x.ll.i; A.223.X.1U; A.224.x.ll.i; A.225.x.ll.i; A.226.x.ll.i; A. 227.x.ll.i; A.228.x.ll.i; A.229.x.ll.i; A.230.x, ll.i; Α.231.Χ.Π.Ϊ; A. 232.x.ll.i; A.233.x.ll.i; A.23 4.x.ll.i; A.235.x.ll.i; A.236.X.1U; A.237.x.ll.i; A.238.x.ll.i; A.239. x.ll.i; 5 A.240.x.ll.i; A.241.x.ll.i; A.242.x.ll.i; A.243.x.ll.i; A.244 .x.11.i; A.245.x.ll.i; A.246.x.ll.i; A.247.X.11A; A.248.x.ll.i; A.249.x .ll.i; A.250.x.ll.i; A.251.x.Hi; A.252.x.ll.i; A.253.x.ll.i; A.254.x.ll .i; A.255.x.ll.i; A.256.x.ll.i; A.257.x.ll.i; A.258.x.ll.i; A.259.x.ll .i; A.260.x.ll.i; A.261.x.ll-i; A.262.x.ll.i; A.263.x.ll.i; A.264.x.ll .i; A.265.X.11.1; A.266.x.ll.i; A.267.x.ll.i; A.268.x.ll.i; A.269.X.111; 10 A.270.X.11.1; A.271.x.ll.i; A.272.x.ll.i; A.273.x.ll.i; Α.274.χ.11Λ; A.275. x.ll.i; A.276.X.UJ; A.277.x.ll.i; Α.278.Χ.11.Ϊ; A.279.x.ll.i; A.280.x. ll.i; A.281.x.ll.i; A.282.x.ll.i; A.283.x.ll.i; A.284.x.ll.i; A.285.x. ll.i; A.286.X.11A; A.287.x.ll.i; A.288.x.ll.i; A.289.X.1U; A.290.x.ll.i; A.291.x.ll.i; A.292.x.ll.i; A.293.x.ll.i; A.294.x.ll.i; A.295.x.ll.i; A.296.x.ll.i; A.297.x.ll.i; A.298.x.ll.i; A.299.x.ll.i; 15 A.300.x.ll.i ; A.301.x.ll.i; A.302.x.ll.i; A303.x.ll.i; A.304.x.ll.i; A.305.x .ll.i; A.306.x.ll.i; A.307.x.ll.i; A.308.x.ll.i; A.309.x.ll.i; A.310.x .ll.i; A.311.x.ll.i; A.312.x.ll.i; A.313.x.ll.i; A.314.X.1U; A.315.x.ll .i; A.316.x.ll.i; A.317.x.ll.i; A.318.x.ll.i; A.319.x.ll.i; A.320.x.ll .i; A.321.x.ll.i; A.323.x.ll.i; A.324.x.ll.i; A.325.x.ll.i; A.326.X.1U ; Α.327.χ.Π.ί; A.328.X.1H; A.329.x.ll.i; Α330.χ.11.Ϊ; 20 A.331.x.ll.i; Α. 332.Χ.1Π; A.333.x.ll.i; A.334.x.ll.i; A.335.x.ll.i; A.336.x.ll.i; A.337. x.ll.i; A.338.x.ll.i; A.339.x.ll.i; A.340.x.ll.i; A.341.x.ll.i; A.342. 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Ϊ; A.398.x.ll.i; A.399.x.ll.i; A.400.x.ll.i; A.401.x.ll.i; A.402.x.ll. i; A.403.x.ll.i; A.404.x.ll.i; A.405.X.1U; A.406.x.ll.i; A.407.x.ll.i; A.408.x.ll.i; A.409.x.ll.i; A.410.x.ll.i; A.411.x.ll.i; A.412.x.ll.i; A.4l3.x.ll, i; A.414.x.ll.i; A.415.x.ll.i; A.416.x.ll.i; A.417.x.ll.i; A.418.x.ll.i; A.419.x.ll.i; A.420.x.ll.i; 35 A.421.x.ll.i; A.422.x.ll.i ; A.423.x.ll.i; A.424.x.ll.i; A.425.x.ll.i; A.426.x.ll.i; A.427.x.ll.i ; A.428.X.1U; A.429.x.ll.i; A.430.x.ll.i; A.431.x.ll.i; A.432.x.ll.i; Α .433.Χ-11.Ϊ; A.434.x.ll.i; A.435.x.ll.i; A.436.x.ll.i; A.437.x.ll.i; A .438.x.ll.i; A.439.xUi; A.440.xUi; A.441.x.ll.i; A.442.x.ll.i; A.443.x.ll.i ; A.444.x.ll.i; A.445.x.ll.i; A.446.x.ll.i; Α.447.χ.1Π; AA 4S.xUi; A.449.x, ll.i; A, 450.x.ll.i; 40 A.451.xUi; A.452.x.ll.i; A.453.x.ll.i ; A.454.x.ll.i; A.455.x.ll.i; A.456.x.ll.i; A.457.x.ll.i; A.458.x.ll.i ; A.459.x.ll.i; A.460.x.ll.i; A.461.x.ll.i; A.462.x.ll.i; A.463.x.ll.i ; A.464.x.ll.i; A.465.x.ll.i; Α.466.χ.11Λ; A.467.x.ll.i; A.468.x.ll.i; A .469.x.ll.i; A.470.x.ll.i; A.471.x.ll.i; A.472.x.ll.i; A.473.X.11A; A.474 .x.ll.i; A.475.x.ll.i; A.476.x.ll.i; A.477.x.ll.i; A.478.x.ll.i; A.479 .x.ll.i; A.480.x.ll.i; 45 Α.481.AX.1Π; A.482.x.ll.i; A.483.x.ll.i; A.484. x.ll.i; A.485.x.ll.i; A.486.x.ll.i; A.4S7.x.ll.i; Α.488.Χ.Π.Ϊ; A.489. x.ll.i; A.49〇.x.ll.i; A.491.x.ll.i; A.492.x.ll.i; A.493.xUi; A.494.x.ll .i; A.495.x.ll.i; A.496.x.ll.i; A.497.x.ll.i; A.498.x.ll.i; A.499.x.ll .i; A.500.x.ll.i; A.501.x.ll.i; A.502.x.ll.i; A.503.x.11.i; A.504.x.ll .i; 148 This paper is in Shizhou Ti! National Standard (CNS) Λ4 is present <UO'OW public t) 4266 6 3 ^ V. Description of the invention (A7 B7 146, 5 10 15 20 25 35 Chinese Ministry of Economic Standards Bureau β: Printed by Industrial and Consumer Cooperatives 40 45 A.505.x.ll.i; A.506.x.ll.i; A.507.x.ll, i; A.508.x.ll.i; A, 509.x.ll. i; A.510.x.ll.i; A.511.x.ll.i; A.512.x.ll.i; A.512.x.ll, i; A.513.x.ll. i; A.514.x.ll.i; A.515.x.ll.i; A.516.x.ll.i; A517.x.ll.i; A518, x-ll.i; A. 519.x.ll.i; A.520.x.ll.i; A.521.x.ll.i; A.522.X.11.X; A.523.x.ll.i; A. 524.x.ll.i; A.525.x, ll.i; A.526.x * ll.i; A.527.x.ll.i; A.52 &amp; x, ll.i; A529. x.ll.i; A.530, x, ll, i; A.531.x-ll_i; A.532a.lLi; A.533_x, ll_i; Α534.χ · 11 · ί; Α535. χ · 11 · ί; Α · 536.χ · 11 · ί; Α.537 · χ.11.ί; Α · 538 · χ.11 · ί; Α.539.χ * 11, ί; A.540. x, lli; A541.x, lLi; A.542.x, llJ; A.543.x.ll.i; A.544.x.ll, i; A.545.x-ll.i; A. 546.x.ll.i; A.547.x.ll, i; A-548.x * ll.i; A.549.x.ll.i; A, 550.x.ll.i; A * 551, x-ll-i; Α.552.Χ.11Λ; A.553, x.ll.i; A.554, x.ll.i; A.555.x.ll.i; A.556. x.ll.i; A.557.x.ll.i; Α.558'χ · 11, ί; A.559.x.ll.i; A.560.x, ll * i; Α · 561 · χ_11.ί; A.562.x, ll_i; A, 563.x.ll, i; A, 564.x.ll.i; A.565.x-ll.i; Α.566.χ, 11. ί; Α.567.χΛ1Λ; A568.x.lli; A.569.x.ll.i; A.57〇.x, ll.i; A , 57LxJl, i; A.572.x.ll * i; Α373.χ.11Λ; A, 574.x.ll.i; A.575, x.ll.i; Α.576.χΛΠ; A577.xAU ; A.578.x.lLi; A.579, x.ll.i; A.580, x.ll.i; A.SSl.x.ll.i; A, 582.x, ll'i; Α · 583 · χ 二 li; Α · 584, χ · 11.ί ;. 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(Rev.) The paper size of the paper is applicable to the Chinese Yan Jiabiao (CNS) A4 grid (21UXW7 mm) 149 4 266 6 3 ^ A7 'B7 V. 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Description of the invention (148) A.581.y.4.i; A.582.y.4.i; A. 583.y.4.i; A.584.y.4.i; A.585.y.4.i; A.586.y.4.i; A.587.y.4.i; A. 588.y.4.i; A.589.y.4.i; A.590.y.4.i; A.59l.y.4.i; A.592.y.4.i; A. 593.y.4.i; A.594.y.4.i; A.595.y.4.i; A.596.y.4.i; A.597.y.4.i; A. 598.y.4.i; A.599.y.4.i; A.600.y.4.i; A.601.y.4.i; A.602.y.4.i; A. 603.v.4.i; A.604.y.4.i; A.605.y.4.i; A.606.y.4.i; A.607.y.4.i; A.608.y.4.i; 5 A.609.y.4.i ; A.610.y.4.i; A.611.y.4.i; A.612.y.4.i; A.613.v.4.i; A.614.y.4.i ; A.615.y.4.i; A.616.y.4.i; A.617.y.4.i; A.618.y.4.i; A.619.y.4.i ; A.620.y.4.i; A.621.y.4.i; A.622.y.4.i; A.623.y.4.i; A.624.y.4.i ; A.625.y.4.i; A.626.y.4.i; A.627.y.4.i; A.628.y.4.i; A.629.y.4.i ; A.630.y.4.i; A.631.y.4.i; A.632.y.4.i; A.633.y.4.i; A.634.y.4.i ; A.635.y.4.i; A.636.y.4.i; A.637.y.4.i; A.638.y.4.i; A.639.y.4.i ; A.640.y.4.i; A.641.y.4.i; A.642.y.4.i; A.643.y.4.i; 0 A.644.y.4. i; A.645.y.4.i; A.646.y.4.i; A.647.y.4.i; A.648.y.4.i; A.649.y.4. i; A.650.y.4.i; A.651.y.4.i; A.652.y.4.i; A.653.y.4.i; A, 654.y.4. i; A.655.y.4.i; A.656.y.4.i; A.657.y.4.i; A.658.y.4.i; A.659.y.4. i; A.660.y.4.i; A.2.y.ll.i; A.3.y.ll.i; A.4.y.ll.i; ASyll.i; A.6 .y.ll.i; A.7.y.ll.i; A.9.y.ll.i; A.lO.y.ll.i; A.15.y.ll.i; A.IOO .y.ll.i; A.IOl.y.ll.i; A.102.y.ll.i; A.103.y.ll.i; A.104.y.ll.i; A.105 .y.ll.i; A.106.y.ll.i; A.107.y.ll.i; A.108.y.ll.i; A.109.y.ll.i; A.llO .y.ll.i; A .lll.y.ll.i; A.112.y.ll.i; A.113.y.ll.i; A.114.y.ll.i; A.115.y.ll.i; A .116.y.ll.i; A.117.y.ll.i; A.118.y.ll.i; A.119.y.ll.i; A.120.y.ll.i; A .121.y.ll.i; A.122.y.ll.i; A.123.y.ll.i; A.124.y.ll.i; A.125.y.ll.i; A .126.y.ll.i; A.127.y.ll.i; A.128.y.ll.i; A.129.y.ll.i; A.130.y.ll.i; A .131.y.ll.i; A.132.v.ll.i; A.133.y.ll.i; A.134.y.ll.i; A.135.y.ll.i; A .136.y.ll.i; A.137.y.ll.i; A.138.y.ll.i; A.139.y.ll.i; A.140.y.ll.i; A .141.y.ll.i; A.142.y.ll.i; A.143.y.ll.i; A.144.y.ll.i; A.145.y.ll.i; A .146.y.ll.i; A.147.y.ll.i; A.148.y.ll.I; A.149.y.ll.i; A.150.y.ll.i; A .151.y.ll.i; A.152.y.ll.i; A.153.y.ll.i; A.154.y.ll.i; A.155.y.ll.i; A .156.y.ll.i; A.157.y.ll.i; A.158.yUi; A.l59.y.ll.i; A.160.y.ll.i; A.161.y .ll.i; A.162.y.ll.i; A.163.y.ll.i; A.164.y.ll.i; A.165.y.ll.i; A.166.y .ll.i; A.167.y.ll.i; A.168.y.ll.i; A.169.y.ll.i; A.170.y.ll.i; A.171.y .ll.i; A.172.y.ll.i; A.173.y.ll.i; A.174.y.ll.i; A.175.y.ll.i; A.176.y .ll.i; A.177.y.ll.i; A.178.y.ll.i; A.179.y.ll.i; A.180.y.ll.i; A.181.y .ll.i; A.182. y.ll.i; A.183.y.ll.i; A.184.y.ll.i; A.185.y.ll.i; A.186.y.ll.i; A.187. y.ll.i; A.188.y.ll.i; A.189.y.ll.i; A.190.y.ll.i; A.192.y.ll.i; A.193. y.ll.i; A.194.y.ll.i; A.195.y.ll.i; A.196.y.ll.i; A.197.y.ll.i; A.198. y.ll.i; A.199.y.ll.i; A.200.y.ll.i; A.201.y.ll.i; A.202.y.ll.i; A.203. y.ll.i; A.204.y.ll.i; A.205.y.ll.i; A.206.y.ll.i; A.207.y.ll.i; A.208. y.ll.i; A.209.y.lLi; A.210.y.ll.i; A.211.y.ll.i; Α.212.ν.Π.ϊ; A.213.y. ll.i; A.214.y.ll.i; A.215.y.ll.i; A.216.y.ll.i; A.217.y.ll.i; A.218.y. ll.i; A.219.y.ll.i; A.220.y.ll.i; A.221.y.ll.i; AJ222.y.ll.i; A.223.y.ll. i; A.224.y.ll.i; A.225.y.ll.i; A.226.y.ll.i; A.227.y.ll.i; A.228.y.ll. i; A.229.y.ll.i; A.230.y.ll.i; A.231.y.ll.i; A.232.y.ll.i; A.233.y.ll. i; A.234.y.ll.i; A.235.y.ll.i; A.236.y.ll.i; A.237.y.lU; A.238.y.ll.i; A.239.y.ll.i; A.240.y.ll.i; A.241.V.1U; A.242.y.ll.i; A.243.y.ll.i; A. 244.y.ll.i; A.245.y.ll-i; A.246.yUi; A.247.y.ll.i; A.248.y.ll.i; A.249.y. ll.i; A.250.y.ll.i; A.251.y.ll.i; A.252.y.ll.i; A.253.y.ll.i; A.254.y. ll.i; A.255.y.ll.i; A.256.y.ll.i; A.257.y.ll.i; A.258.y.ll.i; A.259.y.ll.i; A.260.v.ll.i; A.261.y.ll.i; A.262.y.ll.i; A.263.y.ll.i; A.264.y.ll.i; A.265.y.ll.i; A.266.y.ll.i; A.267.y.ll.i; A.268.y.ll.i; A.269.y.ll.i; A.270, y.ll.i; A.271.y.ll.i; A.272.y.ll.i; A.273.y.ll.i; A.274.y.ll.i; A.275.y.ll.i; A.276.y.ll.i; A.277.y.ll.i; A.278.y.ll.i; A.279.y.ll.i; A.ZSO.y.ll.i; A.281.y.ll.i; A.282.y.ll.i; A.283.v.Il.i; A.284.y.ll.i; A.285.y.ll.i; A.2S6.y.ll.i; A.287.y.ll.i; A.288.y.lU; A.289.y.ll.i; A. 290.y.ll.i; A.291.y.ll.i; A.292.y.ll.i; A.293.y.ll.i; A.294.yUi; A.295.y. ll.i; A.296.y.ll.i; A.297.y.ll.i; A.298.y.ll.i; A.299.y.ll.i; A.300.y. ll.i; A.301.y.ll.i; A.302.y.ll.i; A.303.y.ll.i; A.304.y.ll.i; A.305.y. ll.i; A.306.y.li.i; A.307.y.ll.i; A.308.y.ll.i; A.309.y.ll.i; A.310.y. ll.i; A.311.y.ll.i; please read the back note

I 15 20 ί〇〇 [5 The paper size is in accordance with the Chinese National Standard (CNS) Λ4 specification (public good) -151-赉 Binding) line ο: .5: 0 25 3] 35 Ministry of Economic Affairs: 4 (丨 Standard IΙ4ί: Cooperative cooperative seal% V. Description of the invention (149) A.3l2.y.ll.i; A.313.y.ll.i; A.314y.ll.i; A.315.y.ll.i; A316. y.ll.i; A317.y.ll.i; 'A.318.y.ll.i; A.319.y.lU; A.320.y, ll.i; A.321.V.1U ; A.323.y.ll.i; A324.y.ll.i; A.325.y.ll.i; A326-y.ll.i; A327.y, ll.i; A328.y.ll .i; A.329.yll.i; A.330.yUi; A.331.y.ll.i; A332.y.ll.i; A.333.y.ll, i; A334.y.ll .i; A.335.y, lLi; A336.y.ll.i; A, 337y.ll.i; A338.y.lU; A-339.y.ll.i; A340.y.ll.i ; A.341.yUi; A.342.y.ll.i; A.343, y-lLi; A.344.y.ll.i; A, 345.y, lLi; A.346.y.ll , i; A.347, yll.i; A.348 * y.ll.i; A.349, y.il.i; A.350.y.lli; A351.y.ll.i; A, 352 , y.lLi; A.353.y.ll.i; A.354, y.lLi; A.355.y.lLi; A.356.y.ll.i; A, 357.y.ll, i ; A.358.y.ll.i; A.359, y.ll, i; A.360.y.ll.i; A.361.y-ll, i; A.362, y.lLi; A. .363.y.ll.i; A, 364.y ^ ll.i; A.365.y.lLi; A366.y.lli; A.367.y.ll.i; A.368.y, ll .i; A369.y.lli; A.370.y.lU; A. 371.y.ll.i; A, 372.y.ll.i; A.373.y.ll.i; A.374.y.ll.i; A.375.y.lli; A, 376. y.lLi; A.377.y.lLi; A378.y.ll.i; A, 379.jUl.i; A.380.y.lU; A, 381, yllJ; A.382.y.lli; A-383y.lU; A.384y.lU; A.385.y, ll.i; A.386.y, lli; A.387.y.lLi; A.388.y.lli; A.389, y.ll.i; A.390.y.ll.i; A.391.y.ll.i; A-392.y.lLi; A393.y.lU; A.394.y, lU; A. 395.y, ll.i; A396.y.lli; A.397.y.lU; A.398.y.ll.i; A.399.y.ll.i; A, 400.y.ll. i; A ^ Ol.y.ll.i; A, 402.y.ll.i; A.403.y.lLi; A, 404.y.lli; A.405.y.ll.i; A. 406.y.lU; A.407.y.ll.i; A.408.y, m; A.409.y.ll.i; A, 410.y.ll.i; A, 411.y, ll.i; A.412.y.ll.i; A.413.y.ll.i; A.414.y.ll.i; A.415.y.ll, i; Α.416.νΛΠ; A.417.y.ll.i; A, 418.y, ll.i; A.419.y.lU; A.420.y.lLi; A.421.y.ll.i; A.422. y.ll.i; A.423, y.ll, i; A.424.y.ll, i; A.425.y.lla; A.426.y.ll.i; A.427, y. lLi; A.428y.ll.i; A.429.y.lli; A.43〇 / y.lLi; A.431, y.ll.i; A; 432.y, ll.i; A.433 .y.ll.i; A.434.y.ll, i; A.435.y.ll.i; A.436.y, ll.i; A.437.y.ll.i; A.438 .y.lli; A.439.y.lla; A.440, y.lli; A.441.y.ll.i; A * 442.y.ll.i; A.443.y-ll.i ; A.444, y.lli; A.445.y. ll.i; A, 446.y, ll, i; A, 447.y.lLi; A.448.y.lli; A.449, y.lli; A.450.y.ll.i; A. 451 * y.ll.i; A.452.y.ll, i; A * 453.y.ll.i; A.454_y.ll.i; A.455.y.ll.i; A.456. y.ll.i; A.457.y.ll.i; A.458.y.lLi; A.459.y.ll.i; A, 460.y.lli; A.461.y.ll. i; A.462.y.ll.i; A.463.y.ll.i; A.464 * y, ll.i; A.465-yUi; A.466.y.ll.i; A. 467.y.lla; A.468.yUi; A.469.y, ll.i; A.470.y.ll.i; A.471.y, ll.i; A.472.y, ll. i; A.473.y.ll.i; A.474.y * ll.i; A-475.y.ll.i; A.476.y.lla; A.477.y.ll.i; A.478.y.ll.i; A.479.y.lU; A.480.yUi; A.481.y.ll.i; A.482.y.ll.i; A-483.y. ll.i; A.484.y.ll.i; A.485.y.ll.i; A.486.y.ll.i; A.487.y.ll.i; A.488.y, ll.i; A.489.y.ll.i; A.490.y.ll.i; A.491.y.ll.i; Ai492.y.lli; A.493.y.ll.i; A.494.yJLi; ΑΑ95.γΛ1Λ; A.496.y.lLi; A.497.y.ll.i; A.498.y.ll.i; A.499.y &lt; ll, i; A. 500.y.lla; A.501.y.ll.i; A.502.y.lLi; A.503.y.ll.i; A.504.y.ll.i; A-505.y. ll.i; A.506.y.lLi; A.5〇7.y.ll.i; A.508.y.lLI; A.509.y.ll.i; A.510.y.ll. i; A.51Ly.ll.i; A.512 * y.ll.i; A.51Zy.lLi; A.513.y.lli; A.514.y.ll * i; A.515.y. ll.i; A.516 * y.lLi; A.51 7.y.ll.i; A.518.y.ll.i; A.519, y-ll * i; A.520.y.ll * i; A.521.y.ll.i; A. 522.y, lli; A.523.y.ll.i; A.524.y.ll.i; A.525, y.lU; A.526.y.ll.i; A.527.y. ll.i; A.528.y * lli; A.529.y-ll * i; A.530.y.ll.i; A.531, y.ll.i; A.532.y.ll. i; A.533.y.ll.i; A.534.y.ll_i; A.535.y.ll.i; A.536.y.ll.i; A.537.y.ll.i; A.538.y.ll.i; A.539.y.ll.i; A.540.y.lli; A.541.y.ll.i; A.542, y.ll, i; A. 543.y.ll.i; A.544.y.ll.i; A545.y.ll.i; A.546.y.ll.i; A, 547.y.ll.i; A, 54S. y, ll.i; A.549.y.ll.i; A.550.y.ll, i; A * 551.y.ll.i; A.552.y.lLi; A.553.y * lLi; A.554.y.ll.i; A.555.y.ll.i; A.556.y.ll.i; A.557.y.ll.i; A, 558.y.ll. i; A.559.yJl.i; A.560y.ll.i; A.561.y.ll, i; A.562.y.ll.i; A563.y.ll.i; A, 564. y.lLi; A, 565.y.ll.i; A.566, y.ll.i; A.567.y.ll.i; A.568.y.ll.i; A.569.y. ll.i; A.570, y.ll.i; A, 571.y.li.i; Α.572.} 7.11.ί; A.573.y, ll.i; A.574.y.ll .i; A.575.y.ll.i; A.576.y.iLi; A, 577, y, ll.i; A.578, y.ll.i; A.579.y.ll.i ; A.580.y.ll.i; A581.y.ll.i; A.5S2.y.ll.i; A.5S3.y.Il.i; A.5S4.y.ll.i; A -585-V.ll.i; A.586.y.ll.i; A.587.y.ll.i; A5S8.y.lli; Α.58 9.γ.11Λ; A.590.y.ll.i; Ao91.y.ll.i; A.592.y.lLi; A.593.y.ll.i; A.594, y.ll .i; Α.595.ν.ΠΛ; A.596.y.ll.i; A, 597.y.ll, i; A59S.y, ll.i; A.599.y.ll.i; The paper size is applicable to the Chinese National Standard (CNS) Λ4 specification (2U) X2y? Public address> _ 152 A7 B7 Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs 42666 V. 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-153-4266 6 3 Λ Α7 Β7 V. Description of the invention (151) 5 10 15 &gt; 0

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'1T-Gland-Central Standards of the Ministry of Economics 印 Printed by the Consumer Consumption Cooperatives of the Ministry of Economic Affairs. Printed by the Consumer Standards of the Central Standards Bureau of the Ministry of Economy 4 2 6 6 6 3λ A7 B7 V. Description of the Invention (153) A.409.z.ll.i; A.410.z.ll.i; A.41Lz.ll.i; Α.412.2.11.Ϊ; Α.413.ZZ.11.Ϊ; Α.414.2.Π.Ϊ; A.415.z. ll.i; A.416.z.ll.i; A.417.z.ll.i; A.41S.z.ll.i; A.419.z.ll.i; A.420.z. ll.i; A.421.z.ll.i; A.422.z.ll.i; Α.423.Z.11.Ϊ; A.424.z.ll.i; A.425.z. ll.i; A.426.z.ll.i; A.427.z.ll.i; A.428.z.ll.i; A.429.z.ll.i; A.430.z. ll.i; A.431.z.ll.i; A.432.z.ll.i; 5 A.433.z.ll.i; A.434.z.ll.i; Α.435.Z .Π.1; A.436.z.ll.i; A.437.2.Ui; A.438.z.ll.i; A.439.z.ll.i; A.440.z.ll.i ; A.441-z.ll.i; A.442.2.Ui; A.443.z.ll.i; A, 444.z.ll.i; A.445.z.ll.i; A.446 .z.ll.i; A.447.z.ll.i; A.448.z.ll.i; A.449.z.ll.i; Α.450.2.11.Ϊ; A.451.z .ll.i; A.452.z.ll.i; A.453.z.ll.i; A.454.z.ll.i; A.455.z.ll.i; A.456.z .ll.i; A.457.z.ll.i; Α.458.Z.11.Ϊ; A, 459.z.ll.i; A.460.z.ll.i; A.461.z .ll.i; A.462.z.ll.i; 10 A.463.z.ll.i; A.464.z.ll.i; A.465.2.1U; A.466.z.ll. i; A.467.z.ll.i; A.468.z.ll.i; A.469.z.ll.i; A.470.z.ll.i; A.471.z.ll.i; A.472.z.ll.i; A.473.z.ll.i; A.474.z.ll.i; A.475.z.ll.i; A.476.z.ll.i; A.477.z.ll.i; A.478.z.ll.i; Α.479.2.11.Ϊ; A.480.z.ll.i; A.481.z.ll.i; Α. 482.Z.11.Ϊ; Α.483.Z.11.Ϊ; Α.484.Z.11.Ϊ; A.485.z.ll.i; A.486.z.ll.i; Α. 487.2.11.Ϊ; A.488.2.1U; A.489.z.ll-i; A.490.z.ll.i; A.491.z.ll.i; A.492.z.ll. i; 15 A.493.Z.1U; A.494.z.ll.i; A.495.z.ll.i; A.496.z.ll.i; A.497.z.ll.i ; A.498.Z.Π.Ϊ; A.499.z.ll.i; A.500.2.11.Ϊ; A.SOl.z.ll.i; A.502.z.ll.i; A .503.z.ll.i; A.504.z.ll.i; A.505.2.1U; Α.506.2.11.Ϊ; A5Q7.Z.1U; A.508.Z.1U; A.509 .z.ll.i; A.510.z.ll.i; A.5ll.z.ll.i; Α.512.2.11.Ϊ; A.512.z.ll.i; A.513.z .ll.i; A.514.z.ll.i; A.515.z.ll.i; A.516.z.ll.i; A.517.2.11.i; A.518.z.ll .i; A.519.z.ll.i; Α.520.Z.Π.Ϊ; A.521.z.ll.i; ZO A.522.z.ll.i; A.523.z. ll.i; Α.524.Z.11.Ϊ; Α.525.Z.11.Ϊ; A.526.z.ll.i; A.527.z.ll.i; A.528.2.11, i; A.529.z.ll.i; A.530.z.ll.i; A.531.z.ll.i; A.532.z.ll.i; A.533.z.ll. i; A.534.z.ll.i; A. 535.z.ll.i; A.536.z.ll.i; A.537.z.ll.i; A.538.2.11.i; A.539.z.ll.i; A.540. z, ll.i; A.541.z.ll.i; A.542.z.ll.i; A, 543.z.ll.i; A.544.z.ll.i; A.545. z.ll.i; Α.546.2.11.Ϊ; A.547.z.ll.i; A.548.z.ll.i; Α.549.Z.11Λ; A.550.z.ll. i; A.551.z.ll.i; Ϊ5 Α.552.Z.11Λ; Α.553.2.11.Ϊ; A.554.z.ll.i; A.555.z.ll.i; A .556.z.ll.i; A.557.z.ll.i; A.558.z.ll.i; A.559.z.ll.i; A.560.Z.ll.i; A .561.z.ll.i; A.562.z.ll.i; A.563.z.ll.i; A.564.z.ll.i; A.565.z.ll-i; A .566.z.ll.i; A.567.z.ll.i; A.568.z.ll.i; A.569.z.ll.i; A.570.z.ll.i; A .571.2.11.1; A.572.z.ll.i; A.573.z.ll.i; A.574.Z.11.1; A.575.z.ll.i; A.576.z.ll .i; A.577.Z.1U; A.578.zAU; A.579.z.ll.i; A.SSO.z.ll.i; A.581.z.ll.i;: 10 A .582.z.ll.i; A.583.z.lX.i; Α.584.ZZ.11.Ϊ; A, 585.z.ll.i; Α.586 · ζ.11.ϊ; Α .587.Z.11Λ; A.588.2.11.i; Α.589.ZO.11.Ϊ; Α.590.ZZ.1Π; Α.591.2.1Π; A.592.z.ll.i; A .593.z.ll.i; Av594.z.ll.i; A.595.z.ll.i; A.596.z.ll.i; A.597.z.ll.i; A.598 .z.ll.i; A.599.2.11.i; A.600.z.ll.i; A.601.2.1U; A.602.z.ll.i; Α.603.Z.1Π; A .604.z.ll. i; A.605.z.ll.i; A.606.z.ll.i; Α.607.ZZ.11Λ; A.608.z.ll.i; A.609.2.1U; A.610. z.ll.i; A.611.z.ll.i;:. 5 A.612.z.ll.i; Α.613.Z.11Λ; A.614.z.ll.i; A.615 .z.ll.i; A.616.z.ll.i; A.617,2.11.i; A.618.z.ll.i; A.619.z.ll.i; A.620.z .ll.i; A.621.z.ll.i; A.622.z.ll.i; A.623.z.ll.i; A_624.z.ll'i; A.625.z.ll .i; A, 626.z.ll.i; A.627.z.ll.i; A.628.z.ll.i; A.629.z.ll'i; A.630.z.ll .i; A.631.2.1U; A.632.z.ll.i; A.633.z.ll.i; A.634.z.ll.i; Α.635.2.11.Ϊ; A.636 , z.ll.i; A.637.2.11.1; A.638.z, ll.i; A.639.z.ll.i; A.640.z.ll.i; Α.641.2.Π.Ϊ ; A.642.z.ll.i; A.643.z.ll.i; A.644.z.ll.i; A.645.z.ll.i; A.646.z.ll.i ; A.647.z.ll.i; A.648.z.ll.i; A.649.2.11.1; A.650.z.11.i; A.651.z.ll.i; A.652 .z.ll.i; A.653.z.ll.i; A.654.z.ll.i; Α.655.ζ.11.ί; A.656.z.ll.i; A.657 .z.ll.i; A.658.z.ll.i; A.659.2.11.i; A.660.Z.11.I; A.2.A.4.i; A.3.A .4.i; A.4.A.4.i; Α.5.Α.4.Ϊ; Α.6.Α.4.Ϊ; Α.7.Α.4.Ϊ; Α.9.Α .4.Ϊ; A.10.A.4.:; A.15.A.4.i; A.100.A.4.i; A.101.A.4J; Α.102.Α.4 .Ϊ; 45 Α.103.Α.4.Ϊ; A.104.A.4.i; A.105.A.4.i ; Α.106.Α.4.Ϊ; Α.107.Α.4.Ϊ; A.108.A.4.i; Α.109.Α.4.Ϊ; A.110.A.4.i ; Α.111.Α.4.Ϊ; Α.Π2.Α.4.Ϊ; Α.113.Α.4.Ϊ; A.114.A.4.i; Α.115.Α.4.Ϊ ; Α.116.Α.4.Ϊ; Α.117.Α.4.Ϊ; A.llS.A.4.i; A.119.A.4.i; A.120.A.4.i ; Α.121.Α.4.Ϊ; Α.122.Α.4.Ϊ; A.123.A.4.i; A.124.A.4.i; Α.125.Α.4.Ϊ ; A.126.A.4.i; This paper size is in accordance with the Chinese National Standard (CNS) Λ4 specification (2 (for public waste) _ 156 _

l5i0 · 5_ Q_BJ 5_ 1 I 2-2!: 3 I! 3: 4 * 4f Imprint by the Consumer Cooperatives of the Central Bureau of Standards of the Ministry of Economic Affairs 4 2 6 6 6 3 ^ A7 B7 V. Description of Invention (154) A. 127. A. 4. 1; A. 128. A. 4. i; A. 129. A. 4. i; A. 130. A. 4. i; A. 131. A. 41; Α. 132. Α. 4. Ϊ; Α. 133. Α. 4. Ϊ; A. 134. A. 4. i; Α. 135. Α. 4Λ; A. 136. A. 4. i; Α. 137. Α. 4. Ϊ; Α. 138. Α. 4. Ϊ; A. 139. A. 4. i; Α. 140. Α. 4. Ϊ; A. 141. A. 4. i; Α. 142. Α. 4. Ϊ; A. 143. A. 4. i; Α. 144. Α. 4. Ϊ; Α. 145. Α. 4. Ϊ; A. 146. A. 4. i; A. 147. A. 4. i; A. 14S. A. 4. i; A. 149. A. 4. i; A. 150. A. 4. i; A. 151, A. 4. i; Α. 152. Α. 4. Ϊ; A. 153. A. 4. i; A. 154. A. 4. 1; Α. 155. Α. 4. Ϊ; Α. 156. Α. 4. Ϊ; Α. 157. Α. 4. Ϊ; Α. 158. Α. 4. Ϊ; Α. 159. Α. 4. Ϊ; A. 160. A. 4. i; Α. 161-Α. 4. Ϊ; A. 162. A. 4. i; Α. 163. Α. 4Λ; Α. 164. Α. 4. Ϊ; A. 165. A. 4. i; A. 166. A. 4, i; Α. 167. Α. 4. Ϊ; Α. 168. Α. 4. Ϊ; Α. 169. Α. 4. Ϊ; Α. 170. Α. 4. Ϊ; Α. 171. Α. 4. Ϊ; Α. 172. Α. 4. Ϊ; Α. 173. Α. 4. 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Ϊ; Α. 395. Α. 11. Ϊ; Α. 396. Α. 11. Ϊ; Α. 397. Α. Π. Ϊ; Α. 398. Α. 11. Ϊ; Α. 399. Α. 1Π; Α. 400. Α. 1Π; A. 401. A. 1U; Α. 402. Α. 11. Ϊ; Α. 403. Α. 11. Ϊ; Α. 404. Α. 11. Ϊ; A. 405. A. 1U; A. 406. A. ll. i; Α. 407. Α. 1Π; Α. 408. Α. 11. Ϊ; Λ. 409. Α. 1Π; A. 410. A. ll. i; A. 411. A. ll. i; Α. 412. Α. 11. Ϊ; Α. 413. Α. 11. Ϊ; Α. 414. Α. Π. 1; A. 415. A. ll. i; A. 416. A. 1 l. i; A. 417. A. ll. i; A. 418. A. ll. i; Α. 419. Α. 11. Ϊ; Α. 420. Α. Π. Ϊ; A. 421. A, ll. i; Α. 422. Α. 11. Ϊ; (Please read the precautions on the back before going to this page ¾) — Binding · -Order-Thread-\) · This paper is fully compliant with Chinese National Standards (CNS) A4 ^ Grid (21 «x 扣 7 公 t & gt -159 — ^^^^^-Printed by the Shellfish Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs 4 2 B 6 6 3; A7 B7 V. Description of the invention (15T) Α. 423. Α. 11. Ϊ; A. 424. A. ll. i; A. 425. A. 11. 1; Α. 426. Α. Π. Ϊ; A. 427. A. ll. i; A. 428. A. ll. i; Α. 429. Α. 11. 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A. 1U; A. 488. A. ll. i; Α. 489. Α. 11. Ϊ; Α. 490. Α. 11. Ϊ; Α. 491. Α. Π. Ϊ; A. 492. A. ll. i; A. 493. A. ll. i; A. 494. A. 1U; A. 495. A. lLi; A. 496. A. ll. i; A. 497. A. 11J; A * 498. A. ll. i; Α. 499. Α. 1Π; A. SOO. A. ll. i; Α. 501. Α. 11. Ϊ; A. 502. A. ll. i; Α. 503. Α. 1Π; A. 504. A. ll. i; Α. 505. Α. 11. Ϊ; Α. 506. Α. 11. Ϊ; A. 507. A. 1U; Α. 508. Α. 11. Ϊ; Α. 509. Α. 11. Ϊ; Α. 510. Α. 11. Ϊ; A. SXl. A. ll. i; Α. 512. Α. Π. Ϊ; Α. 512. Α. 1Π; Α. 513. Α. 11. Ϊ; Α. 514. Α. Π. Ϊ; A. 515. A. ll. i; A. 516. A. ll. i; Α. 517. Α. 11. Ϊ; Α. 518. Α. 11. Ϊ; A. 519. A. ll. i; Α. 520. Α. 11. Ϊ; Α. 521. Α. 11. Ϊ; Α. 522. Α. Π. Ϊ; Α. 523. Α. 11. Ϊ; A. 524. A. U. 1; A. 525. A. 11. 1; Α. 526. Α. 11. Ϊ; A. 527. A. ll. i; Α. 528. Α. 11. Ϊ; Α. 529. Α. 11. Ϊ; Α. 530. Α. 11. Ϊ; A. 531. A. 1U; Α. 532. Α. 11. Ϊ; Α. 533. Α. 11. Ϊ; Α. 534. Α. Π. Ϊ; Α. 535. Α. 11. Ϊ; Α. 536. Α. 11. Ϊ; Α. 537. Α. 11. Ϊ; A. 538. A. ll. i; Α. 539. Α. Π. Ϊ; A. 540. A. ll; i; Α. 541. Α. Π. Ϊ; Α. 542. Α. 11. Ϊ; Α. 543. 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Β. 4. 疋; This paper is in accordance with Chinese National Standard (CNS) Λ4Λ grid (21CIX 297 Gongjie) -160-(Please read the note on the back before filling this page) Order printed by the Central Consumers Bureau of the Ministry of Economic Affairs Consumer Cooperative Invention description (15δ) A. l42. B. 4. i; A. 143. B. 4J; Α. 144. Β. 4. Ϊ; A. 145. B. 4. i; A. M6. B; 4. i; Α. 147. Β. 4. Ϊ; Α. 148. Β. 4. Ϊ; A. 149. B. 4. i; Α. 150. Β. 4. Ϊ; Α. 151. Β. 4. Ϊ; A. 152. B. 4. i; Α. 153. Β. 4. Ϊ; A. 154. B. 4. i; A. 155. B. 4. 1; A. 156. B. 4. i; A. 157. B. 4. i; A. 158. B. 4. i; A. 159. B. 4. i; Α. 160. Β. 4. Ϊ; Α. 161. Β. 4. Ϊ; Α. 162. Β. 4. Ϊ; A. 163. B. 4. i; Α. 164. Β. 4. Ϊ; A. 165. B. 4. i; 5 Α. 166. Β. 4. Ϊ; Α. 167. Β. 4. Ϊ; A. 168. B. 4. i; ΑΛ69. ΒΑΛ; Α. 170. Β. 4. Ϊ; A. 171. B. 4. i; Α. 172. Β. 4. Ϊ; Α. 173. Β. 4. Ϊ; Α. 174. Β. 4. Ϊ; Α. 175. Β. 4. Ϊ; Α. 176. Β. 4. Ϊ; Α. 177. Β. 4. Ϊ; Α. 178. Β. 4. Ϊ; ΑΛ79. Β. 4. Ϊ; A. 18〇. B. 4. i; Α. 181. Β. 4. Ϊ; Α. 182. Β. 4. Ϊ; Α. 183. 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B. 4. i; Α. 419. Β. 4. Ϊ; Α. 420. Β. 4. Ϊ; A. 421. B. 4. i; A. 422. B. 4. i; Α. 423. Β. 4. Ϊ; A. 424. B. 4. 1; A. 425. B. 4. i; A. 426. B. 4. i; A. 427. B. 4. 1; A. 428. B. 4. i; A. 429. B. 4. i; A. 430, B. 4. i; This paper size applies the Chinese National Standard (CNS) Λ4 is now (210X2W public goods) — 161 n If n ϋ n-nn I nnn 1 I: I — II (Please read the precautions on the back first>%- (This page) 4266 6 3 Λ at A B7 Printed by the Central Bureau of Standards of the Ministry of Economic Affairs JE-Consumer Cooperative Society 431. Β. 4. Ϊ; Α. 432. Β. 4. ί; Α. 433. Β. 4. Ϊ; Α. 434. Β. 4. Ϊ; Α. 435. Β. 4. Ϊ; Α. 436. Β. 4. Ϊ; A. 437. B. 4. i; Α. 438. Β. 4. Ϊ; Α. 439. Β. 4. Ϊ; A. 440. B. 4. 1; Α. 441. Β. 4. Ϊ; Α. 442. Β. 4. Ϊ; Α. 443. Β. 4. Ϊ; Α. 444. Β. 4. Ϊ; Α. 445. Β. 4. Ϊ; Α. 446. Β. 4. Ϊ; A. 447. B. 4. i; Α. 448. Β. 4. Ϊ; Α. 449. Β. 4. Ϊ; Α. 450. Β. 4. Ϊ; Α. 451. Β. 4. Ϊ; Α. 452. Β. 4. Ϊ; Α. 453. Β. 4. Ϊ; Α. 454. Β. 4. Ϊ; 5 Α. 455. Β. 4. Ϊ; Α. 456. Β. 4. Ϊ; ΑΑ57. ΒΛΛ; A. 458. 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In m _ -bound. The size of the paper is suitable for Chinese National Standards (CNS) 8 and 4 (210X297 cm) — _ 4 2 6 6 6 3 A7 _ ^ _ B7 V. Description of the invention (161) Α.438 .Β.11.Ϊ; Α.439.Β.Π.Ϊ; Α.440.Β.11.Ϊ; Α.441.Β.11.Ϊ; Α.442.Β.11.Ϊ; Α.443 .Β.11.Ϊ; A.444.B.ll.i; Α.445.Β.11.Ϊ; Α.446.Β.11.Ϊ; Α.447.Β.11.Ϊ; Α.448 .Β.Π.Ϊ; Α.449.Β.11.Ϊ; Α.450.Β.1Π; Α.451.Β.11.Ϊ; Α.452.Β.11.Ϊ; Α.453.Β .Π.Ϊ; A.454.B.lLi; Α.455.Β.11.Ϊ; Α.456.Β.11.Ϊ; Α.457.Β.11.Ϊ; Α.458.Β.11 .Ϊ; Α.459.Β.Π.Ϊ; A.460.B.ll.i; Α.461.Β.11.Ϊ; 5 Α.462.Β.11.Ϊ; Α.463.Β. 11.Ϊ; A.464.B.ll.i; Α.465.Β.11.Ϊ; A.466.B.1U; Α.467.Β.Π.Ϊ; A.468.B.1U; A.469.B.1U; Α.470.Β.11.Ϊ; Α.471.Β.11.Ϊ; A.472.B.ll.i; A.473.B.lLi; Α.474. Β.11Λ; A.475.B.ll.i; Α.476.Β.11.Ϊ; A.477.B.ll.i; A.478.B.ll.i; A.479.B. 1U; Α.480.Β.1Π; A.481.B.1U; Α.482.Β.11.Ϊ; Α.483.Β.11.Ϊ; A.484.B.1U; Α.485. Β.11.Ϊ; Α.486.Β.1Π; Α.487.Β.11.Ϊ; Α.488.Β.11.Ϊ; A.489.B.ll.i; A.490.B. 11.:; Α.491.Β.11.Ϊ;: 0 A.492.B.ll.i; Α.493.Β.11.Ϊ; Α.494.Β.11.Ϊ; Α.495.Β.11.Ϊ; Α.496.Β.1Π; A .497.B.ll.i; A.498.B.ll.i; Α.499.Β.11.Ϊ; A.SOO.B.ll.i; A.SOl.B.ll.i; Α .502.Β.1Π; A.503.B.ll.i; Α.504.Β.11.Ϊ; A.505.B.ll.i; A.506.B.11.Z; Α.507 .Β.11.Ϊ; A.508.B.ll.i; A.509.B.ll.i; Α.510.B.11.Ϊ; A.511.B.ll.i; Α.512 .Β.11.Ϊ; Α.512.Β.11.Ϊ; Α.513.Β.11.Ϊ; A.514.B.1U; Α.515.Β.11.Ϊ; Α.516.Β .11.Ϊ; A.517.B.ll.i; A.518.B.ll.i; A.519.B.1U; A.520.B.ll.i; 15 Α.521.Β. Π.Ϊ; A.522.B.1U; A.523.B.1U; A.524.B.11.1; Α.525.Β.11.Ϊ; Α.526.Β.1Π; Α.527. Β.11.Ϊ; A.528.B.11.I; A.529.B.1U; Α.530.B.11.Ϊ; A.531.B.1U; Α.532.Β.11. Ϊ; A.533.B.1U; Α.534.Β.11.Ϊ; A.535.B.1U; Α.536.Β.11.Ϊ; Α.537.Β.11.Ϊ; A. 538.B.1U; A.539.B.1U; A.540.B.ll.i; Α.541.Β.1Π; Α.542.Β.11.Ϊ; Α.543.Β.11. Ϊ; A.544.B.ll.i; A.545.B.11.U Α.546.Β.11.Ϊ; A.547.B.1U; Α.548.Β.11.Ϊ; Α .549.Β.11.Ϊ; Α.550.Β.11.Ϊ; 20 Α.551.Β.Π.Ϊ; A.552.B.ll.i; Α.553.Β.1Π; Α. 554.Β.11.Ϊ; A.555.B.ll.i; A.556. B.ll.i; Α.557.Β.11.Ϊ; Α.558.Β.Π.Ϊ; A.559.B.ll.i; Α.560.Β.Π.Ϊ; A.561. B.ll.i; A.562.B.ll.i; A.563.B.1U; A.564.B.1U; Α.565.Β.Π.Ϊ; A.566.B.1U; A.567.B.ll.i; Α.568.Β.11.Ϊ; A.569.B.ll.i; Α.570.Β.11.Ϊ; Α.571.Β.1Π; Α. 572.Β.1Π; Α.573.Β.1Π; A.574.B.1U; 25 3) 3, j Staff fee of Economic Standard Bureau 43 Cooperative Α.575.Β.11.Ϊ; Α.576.Β .11.Ϊ; Α.577.Β.11.Ϊ; A.578.B.1U; A.579.B.1U; A.580.B.1U; Α.581.Β.1Π; Α.582 .Β.11.Ϊ; Α.583.Β.11.Ϊ; Α.584.Β.11.Ϊ; Α.585.Β.11.Ϊ; Α.586.Β.11.Ϊ; Α.587 .Β.11.Ϊ; Α.588.Β.11.Ϊ; Α.589.Β.11.Ϊ; A.590.B.1U; Α.591.Β.χ1.Ϊ; Α.592.Β .11.Ϊ; A.593.B.ll.i; Α.594.Β.Π.Ϊ; A.595.B.ll.i; A.596.B.ll.i; A.597.B .ll.i; A.598.B.11.1; A.599.B.ll.i; A.600.B.ll.i; A.601.B.1U; A.602.B.ll.i ; A.603.B.ll.i; A.604.B.1U; Α.605.Β.11.Ϊ; A.606.B.ll.i; A.607.B.1U; A.608 .B.ll.i; A.609.B.ll.i; A.610.B.ll.i; Α.6Π.Β.11.Ϊ; Α.612.Β.11.Ϊ; Α.613 .Β.11.Ϊ; Α.614.Β.11.Ϊ; A.615.B.ll.i; Α.6Ι6.Β.Π.1; Α.617.Β.11.Ϊ; Α.618 .Β.1Π; Α.619.Β.11.Ϊ; A.620.B.ll.i; A.621.B.ll.i; A.622.B.ll.i; Α.623.Β.11Λ; Α. 624.Β.1Π; Α.625.Β.1Π; A.626, B.1U; A.627.B.ll.i; A.628.B.ll.i; Α.629.Β.Π. Ϊ; A.630.B.ll.i; A.631.B.ll.i; Α.632.Β.11.Ϊ; A.633.B.ll.i; A.634.B.ll. i; A.635.B.ll.i; Α.636.Β.11.Ϊ; A.637.B.ll.i; A.638.B.ll.i; A.639.B.1U; Α.640.Β.11Λ; A.641.B.ll.i; Α.642.Β.11.Ϊ; A.643.B.ll.i; A.644.B.1U; Α.645. Β.11Λ; Α.646.Β.1Π; Α.647.Β.11.Ϊ; Α.648.Β.11.Ϊ; A.649.B.1U; Α.650.Β.1Π; Α. 651.Β.11Λ; A.652.B.1U; A.653.B.ll.i; A.654.B.1U; Α.655.Β.1Π; Α.656.Β.11.Ϊ; A.657.B.lLi; A.658.B.ll.i; Α.659.Β.11.Ϊ; A.66O.B.II.1; A.2.C.4.i; A. 3.C.4.i; A.4.C.4.i; A.5.C.4.i; A.6.C.4.i; A.7.C.4.i; A. 9.C.4.i; A.10.C.4.i; A.15.C.4.i; A.100.C.4.i; A.IOl.CAi; A.102.C. 4.1; A.103.C.4.i; A.104.C.4.i; A.105.C.4.i; A.106.C.4.i; A.107.C.4. i; A.108.C.4.i; A.109.C.4.i; A.110.C4.i; A.lll.C.4.i; A.112.C.4.i; A.113.C.4.i; A.114.C.4.i; A.115.C.4.i; A.116.C.4.i; A.117.C.4.i; A.118.C.4.i; A.119.C.4.i; A.120.C.4.1; A.121.C .4.i; A.122.C.4.i; A.123.C.4.i; A.124.C.4.i; A.125.C.4.i; A.126.C .4.i; A.127.C.4.i; A.128.C.4.i; A.129.C.4.i; A.13〇.C.4.i; A.131. C.4.i; A.132.C.4.i; A.133.C.4.i; A.134.C.4.i; A.135.C.4.i; A.136. C.4.i; A &quot;137.C.4.i;A.138.C.4.i;A.139.C.4.i;A.140.C.4.i; A.141. C.4.i; A.142.C.4.i; A.143.C.4.i; A.144.C.4.i; A.145.C.4.i; A.146. C.4.i; A.147.C.4.i; A.148.C.4.i; A.149.C.4.i; A.150.C.4.i; A.151. C.4.i; A.l52.C.4.i; A.153.C.4.i; A.154.C.4.i; A.155.C.4.Z; A.156. C.4.i; This paper size is applicable to the national standard (CNS) A4 regulations of each week (2 丨 〇 &gt; &lt; 29 Secret) _ 164 5 ο

P Φ 1--c UJ in the Ministry of Economic Affairs * 4 The staff of the Bureau of Accreditation of the iH cooperate with Du Du to print. 5. Description of the invention (162) A.157.C.4.i; A.158.C.4.i; A .159.C.4.i; A.160.C.4.i; A.161.C.4.i; A.162.C.4.i; A.163.C.4.i; A .164.C.4.I; A.165.C.4.i; A.166.C.4.i; A.167.C.4.i; A.168.C.4.i; A. .169.C.4.i; A.170.C.4.i; A.171.C.4.i; A.172.C.4.i; A.173.C.4.i; A. .174.C.4.i; A.175.C.4.i; A.176.C.4.i; A.177.C.4.i; A.17S.C.4.i; A. .179.C.4.i; A.180.C.4.i; A.181.C.4.i; A.182.C.4.i; A.183.C.4.i; A. .184.C.4, i; A.185.C.4.i; A.186.C.4.i; A.187.C.4.1; A.188.C.4.i; A.189 .C.4.i; A.190.C.4.i; A.191.C.4.i; A.192.C.4.i; A.193.C.4.1; A.194.C .4.i; A.195.C.4.i; A.196.C.4.i; A.197.C.4.i; A.198.C.4.i; AmCA.i; A.200.C.4.i; A.201.C.4.i; A.202.C.4.i; A.203.C.4.i; A.204.C.4.i; A.205.C.4.i; A.206.C.4i; A.207.C.4.i; A.208.C.4.1; A.209.C.4.i; A.210. C.4.i; A.211.C.4.i; A.212.C.4.i; A.213.C.4.1; A.214.C.4.i; A.215.C. 4.i; A.216.C.4.1; A.217.C.4.i; A.218.C.4.i; A.219.C.4.1; A.220.C.4.i; A.221.C.4.1; A.222.C.4.i; A.223.C.4.i; A.224.C.4.1; A.225.C.4.i; A.226.C.4.i; A.227.C.4.i; A.228.C.4.i; A.229.C.4.i; A.230.C.4.i; A.231.C.4.i; A.232.C.4.i; A.233.C.4.1; A.234.C.4.i; A.235.C.4.i; A. 236.C.4.i; A.237.C.4.i; A.238.C.4.i; A.239.C.4.i; A.240.C.4.i; A. 241.C.4.i; A.242.C.4.1; A.243.C.4.i; A.244.C.4.i; A.245.C.4.1; A.246.C. 4.i; A.247.C.4.i; A.248.C.4.i; A.249.C.4.1; A.250.C, 4.i; A.251.C.4. i; A.252.C.4.i; A.253.C.4.i; A.254.C.4.i; A.255.C.4.i; A.256.C.4. i; A.257.C.4.i; A.258.C.4.i; A.259.C.4.i; A.260.C.4.i; A.261.C.4. i; A.262.C.4.i; A.263.C.4.i; A.264.C.4.i; A.265.C.4.i; A.266.C.4. i; A.267.CAA; A.268.C.4.i; A.269.C.4.i; A.27Q.C.4.i; A.271.C.4.i; A. 272.C.4.i; A.273.C.4.i; A.274.C.4.i; A.275.C.4.i; A.276.C.4.i; A. 277.C.4.i; A.278.C.4.i; A.279.C.4.i; A.280.C.4.i; A.281.C.4.i; A. 282.C.4.i; A.2S3.C.4.1; A.284.C.4.i; A.285.C.4.i; A.286.C.4.i; A.287. C.4.i; A.2S8.C.4.i; A.289.C.4.i; A.290.C.4.i; A.291.C.4.i; A.292. C.4.i; A.293.C.4.i; A.294.C.4.i; A.295.C.4.i; A.296.C.4.i; A.297. C.4.i; A.298, C.4.i; A.299.C4.i; A.300.C.4.i; A.301.C.4.i; A. 302.C-4.1; A303.C.4.i; A.304.C.4.i; A305.C.4.i; A.306.C.4.i; A.307.C.4. i; A.308.C.4.i; A.309.C.4.i; A.310.C.4.i; A.311.C.4.i; A.312 * C.4. i; A.313.C.4.i; A.314.C.4.i; A.315.C.4.i; A.316.C.4.i; A317.CAA; A.318. C.4.i; A.319.C.4.i; A.320.C.4.i; A.321.C.4.i; A.323.C.4.i; A.324. C.4.i; A.325.C.4.1; A.326.C.4.i; A.327.C.4.i; A.328, C.4.i; A.329.C. 4.i; A.33〇.C.4.i; A.331.C.4.i; A.332.C.4.i; A.333.C.4.i; A.334.C .4J; A.335.C.4.i; A.336.C.4.i; A.337.C.4.i; A.338.C.4.i; A.339.C.4 .i; A.340.C.4.i; A.341.C.4.i; A.342.C.4.i; A.343.C.4.i; A.344.C.4.1 ; A.345.C.4.1; A.346.C.4.i; A.347.C.4.i; A.348.C.4.i; A.349.C.4.i; A. .350.C.4.i; A.351.C.4.i; A.352.C.4.i; A.353.C.4.i; A.354.C.4.i; A. .355.C.4.i; A.356.C.4.i; A.357.C.4.i; A.358.C.4.i; A.359.C.4.1; A.36 〇.C.4.i; A.361.C.4.i; A.362.C.4.1; A.363.C.4.i; A.364.C.4.i; A.365. C.4.i; A.366.C, 4.i; A.367.C.4.i; A.368.C.4.i; A.369.C.4.i; A.370. C.4.i; A.371.C.4.i; A.372.C.4.1; A.373.C.4.i; A.374.C.4.i; A.375.C. 4.i; A.376.C.4.i; A.377.C.4.i; A.378.C.4.i; A.37 9.C.4.i; A.380.C.4.i; A.381.C.4.i; A.382.C.4.i; A.383.C.4.i; A. 384.C.4.i; A.385.C.4.i; A.386.C.4.i; A.387.C.4.1; A.388.C.4.i; A.389. C.4.i; A.390.C.4.i; A.391.C.4.i; A.392.C.4.i; A.393, C.4.i; A.394. C.4.i; A.395.C.4.i; A.396.C.4.i; A.397.C: 4.i; A.398.C.4.i; A.399. C.4.i; A.400.C.4.i; A.401.C.4.1; A.402.C.4.i; A.403.C.4.i; A.404.C. 4.i; A.405.C.4.i; A.406.C.4.i; A.407.C.4.i; A.408.C.4.i; A.409.C. 4.i; A.410.C.4.i; A.411.C.4.i; A.412.C.4.1; A.413.C.4.i; A.414.C.4. i; A.415.C.4.i; A.416.C.4.i; A.417.C.4.i; A.418.C.4.i; A.419.C.4. i; A.420.C.4.i; A.421.C.4.i; A.422.C.4.i; A.423.C.4.1; A.424.C.4i; A. 425.C.4.i; A ': 426.C.4.i; A.427.C.4.i; A.42S.C.4.i; A.429.C.4.i; A .430.C.4.1; A.431.C.4.i; A.432.C.4.i; A.433.C.4.I; A.434.C.4.i; A.435 .C.4.i; A.436.C.4.i; A.437.C.4.i; A.438.C.4.i; A.439.C.4.i; A.440 .C.4.i; A.441.C.4.i; A.442.C.4.i; A.443.C.4.i; A.444.C.4.i; A.445 .C.4.i; This paper size is applicable to the national standard (CNS) of the towel (210X29 * 7) -165-5 V. Description of the invention (163) 0: 5 20 25 3) 3! Economy? C4C quasi bureau

Cooperatives A.446.C.4.i; A.447.C.4.i; A.448, C.4.i; A.449.C.4.i; A.450.C.4.i ; A.451.C.4.i; A.452.C.4.i; A.453.C.4.i; A.454.C.4.1; A.455.C.4.i; A .456.C.4.i; A.457.C.4.i; A.45S.C.4.i; A.459.C.4.i; A.460.C.4.i; A. .461.C.4.i; A.462.C.4.i; A.463.C.4.i; A.464.C.4.i; A.465.C.4.1; A.466 .C.4.i; A.467.C.4.i; A.468.C.4.i; A.469.C.4.i; A.470.C.4.1; A.471.C .4.i; A.472.C.4.i; A.473.C.4.i; A.474.C.4.i; A.475.C.4.i; A.476.C .4.i; A.477.C.4.i; A.478.C.4.i; A.479, C.4.i; A.480.C.4.i; A.481.C .4.i; A.482.C.4.i; A.483.C.4.i; A.484.C.4.i; A.485.C.4.i; A.486.C .4.i; A.487.C.4.i; A.488.C.4.i; AmCA: v, A.490.C.4.i; A.491.C.4.i; A.492.C.4.i; A.493.C.4.i; A.494.C.4.1; A.495.C.4.i; A.496.C.4.i; A. 497.C.4.i; A.498.C.4.1; A.499.C.4.i; A.500.C.4.i; A.501.C.4.i; A.502. C.4.i; A.503.C.4.i; A.504.C.4.i; A.505.C.4.i; A.506.C.4.i; A.507. C.4.i; A.508.C.4.i; A.509.C.4.i; A.510.C.4.i; A.511.C.4.i; A.512. C.4.i; A.512.C.4.i; A.513.C.4.i; A.514.C.4.i; A.515.C.4.i; A.516. C.4.1; A.517.C.4.i; A.518.C.4.i; A.519.C.4.1 ; A.52〇.C.4.i; A.521.C.4.i; A.522.C.4.i; A.523.C.4.i; A.524.C.4. i; A.525.C.4.i; A.526.C.4.i; A.527.C.4.i; A.528.C.4.i; A.529.C.4.1; A.530.C.4.i; A.531.C.4.i; A.532.C.4.i; A.533.C.4.i; A.534.C.4.i; A.535.C.4.i; A.536.C.4.i; A.537.C.4.i; A.538.C.4.i; A.539.C.4.i; A.540.C.4.i; A.541.C.4.i; A.542.C.4.i; A.543.C.4.i; A.544.C.4.i; A.545.C.4.i; A.546.C.4.i; A.547.C.4.i; A.548.C.4.i; A.549.C.4.i; A.550.C.4.i; A.551.C.4.i; A.552.C.4.i; A.553.C.4.1; A.554.C.4.i; A. 555.C.4.i; A.556.C.4.i; A.557.C.4.i; A.558.C.4.i; A.559.C.4.i; A. 560.C.4.i; A.561.C.4.i; A.562.C.4.i; A.563.C.4.i; A564; C.4.i; A.565. C.4.i; A.566.C.4.i; A.567.C.4.i; A.568.C.4.i; A.569.C.4.i; A.570. C.4.i; A.571.C.4.i; A.572.C.4.i; A.573.C.4.i; A.574.C.41; A.575.C. 4.i; A.576.CA.1; A.577.C.4.i; A.578.C.4.1; A.579.C.4.i; A.580.C.4.1; A. 581.C.4.i; A.582.C4.i; A.583.C.4.i; A.5S4.C.4.i; A.585.C.4.i; A.586. C.4.i; A.587.C.4.i; A.588.C.4.i; A.589.C.4.i; A.590.C.4.i; A.591. C.4.i; A.592.C.4.i; A.593.C.4.i; A.594.C.4.i; A.5 95.C.4.1; A.596.C.4.i; A.597.C.4.i; A.598.C.4.i; A.599.C.4.i; A.600. C.4.i; A.601.C.4.i; A.602.C.4.i; A.603.C.4.Z; A.604.C.4.i; A.605. C.4.i; A.606.C.4.i; A.607.C.4.i; A.608.C.4.i; A.609.C.4.i; A.610. C.4.i; A.611.C.4.1; A.612.C.4.i; A.613.C.4.i; A.614.C.4.i; A.615: C. 4.i; A.616.C.4.i; A.617.C.4.i; A.618.C.4.i; A.619.C.4.i; A.620.C. 4.i; A.621.C.4.i; A.622.C.4.i; A.623.C.4.i; A.624.C.4.i; A.625.C. 4.I; A.626.C.4.i; A.627.C.4.i; A.628.C.4.i; A.629.CU; A.630.C.4.i; A.631.C.4.i; A.632.C.4.i; A.633.C.4.i; A.634.C.4.i; A.635.C.4.i; A.636.C.4.i; A.637.C.4.1; A.638.C.4.1; A.639.C.4.i; A.640.C.4.i; A.641. C.4.i; A.642.C.4.i; A.643.C.4.i; A.644.C.4.i; A.645.C.4.i; A.646. C.4.i; A.647.C.4.i; A.648.C.4.i; A.649.C.4.i; A.650.C.4.i; A.651. C.4.i; A.652.C.4.i; A.653.C.4.i; A.654.C.4.i; A.655.C.4.i; A.656. C.4.1; A.657.C.4.i; A.658.C.4.i; A.659.C.4.i; A.66〇.C.4.i; A.2.C .ll.i; A.3.C.1U; A.4.C.1U; A.5.C.1U; A.6.C.ll.i; A.7.Cll.i; A.9 .C.ll.i; A.10.Cll.i; A.15.C.ll.i; A.lOO.C.ll.i; A.IOl .C.ll.i; A.102.C.ll.i; A.103.C.ll.i; A.104.C.ll.i; A.lOS.C.ll.i; A.106 .C.ll.i; A.107.C.1U; A.108.C.ll.i; A.109.C.ll.i; A.110.C.1U; A.lll.ClU; A .112.C.ll.i; A.113.C.ll.i; A.114.C.1U; A.115.C.ll.i; A.116.C.ll.i; A.117 .Cll.i; A.118.C.1U; A.119.C.ll.i; A.120.C.1U; A.121.C.1U; A.122.C1U; A.123.Cll .i; A.124.Cll.i; A.125.C.1U; A.126.CUi; A.127.C.ll.i; A.128.C.1U; A.129.C.ll .i; A.130.C.ll.i; A.ISl.C.ll.i; A.132r.ll.i; A.133.C.ll.i; A.134.C.ll.i ; A.135.C.il.i; A.136.CUi; A.137.C.ll.i; A.138.C.ll.i; A.139.C.1U; A.140.C .ll.i; A.141.C.ll.i; A.142.C.ll.i; A.143.Cl !: i; A.144.C.ll.i; A.145.C. ll.i; A.146.C.ll.i; A.147.C.lLi; A.14S.C.1U; A.149.C.ll.i; A.150.C.ll.i; A.ISl.C.ll.i; A.152.C.ll.i; A.153.C.ll.i; A.154.C.1U; A.155.C.ll.i; A. 156.C.ll.i; A.157.C.ll.i; A.15S.C.ll, i; A.159.C.ll.i; A.160.C.ll.i; A. 161.C.ll.i; A.162.CHi; A.163.C.ll.i; This paper standard is universal Chinese storehouse standard (CNS) Λ4 specification (210: 07 public broadcasting) 166-中心 4 &lt;丨 Printed by Standard Bureau member cooperatives 4 2 6 6 6 3, A? ___ B7___ V. Description of the invention (164) A.164.C.ll.i; A.165.CUi; A.166.C.ll.i; A.167.C.ll.i; A.168.C .ll.i; A.169.G.ll.i; A.170.C.ll.i; A.171.C.ll.i; A.172.C.ll.i; A.173.C .ll.i; A.174.C.1U; A.175.C.ll.i; A.176.C.ll.i; A.177.C.1U; A.178.C.ll.i ; A.179.C.ll.i; A.ISO.C.ll.i; A.ISl.C.ll.i; A.182.C.ll.i; A.183.C.ll.i ; A.184.C.ll.i; A.185.C.ll.i; A.186.C.ll.i; A.187.C.1U; &gt;A.188.C.ll.i;A.189.C.ll.i;A.190.C.1U;A.191.C.ll.i;A.192.C.ll.i;A.193.C.ll.i; A .194.C.ll.i; A.195.C.ll.i; A.196.C.ll.i; A.197.C.1U; A.198.C.ll.i; A.199 .C.ll.i; A.200.C.ll.i; A.201.C.ll.i; A.202.C.ll.i; A.203.C.ll.i; A.204 .C.ll.i; A.205.C.ll.i; A.206.CUi; A.207.C.ll.i; A.208.C.ll.i; A.209.C1U; A. .2lO.C.ll.i; A.211.C.1U; A.212.Cll.i; A.213.C.ll.i; A.214.C.ll.i; A.215.C .ll.i; A.216.Cll.i; A.217.C.ll.i;) A.218.C.ll.i; A.219.C.ll.i; A.220.C. ll.i; A.221.C.ll.i; A.222.C.ll.i; A.223.C.ll.i; A.224.C.ll.i; A.225.Cll. i; A.226.C.1U; A.227.C.ll.i; A.228.C.1U; A.229.C.ll.i; A.230.C.ll.i; A. 231.C.ll.i; A.232.C.ll.i; A.233.Cni; A .234.C.ll.i; A.235.C.ll.i; A.236.C.ll.i; A.237.C.1U; A.238.C.ll.i; A.239 .C.1U; A.240.C.ll.i; A.241.C.ll.i; A.242.C.ll.i; A.243.C.1U; A.244.C.ll .i; A.245.C.ll.i; A.246.C.ll.i; A.247.C11.X; ί A.248.C.ll.i; A.249.C.1U; A.250.C.ll.i; A.251.C.1U; A.252.C.ll.i; A.253.C.ll.i; A.254.C.ll.i; A. 255.C.ll.i; A.256.C.1U; A.257.C.ll.i; A.258.C.ll.i; A.259.C.ll.i; A.260. 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C.ll.i; A.277.C.ll.i; such as A.278.C.ll.i; A.279.C.ll.i; A.280.C.ll.i; A.281 .C.ll.i; A.282.C.1U; A.283.C.ll.i; A.284.Cll.i; A.285.C.ll.i; A.286.C.ll .i; A.287.C.ll.i; A.288.C.1U; A.289.C.ll.i; A.290.C, ll.i; A.291.C.ll.i ; A.292.C.ll.i; A.293.C.ll.i; A.294.Cll.i; A.295.C.ll.i; A.296.C.ll.i; A .297.C.ll.i; A.29S.C.ll.i; A.299.C.ll.i; A.300.C.1U; A.301.C.ll.i; A302.C .1U; A.303.C.ll.i; A304.C.ll.i; A.305.C.ll.i; A.306.C.ll .i; A.307.C.ll.i; A.308.C.ll.i; A.309.C.ll.i; A.310.C.ll.i; A.311.Cni; A .312.Cll.i; A.313.C.ll.i; A.314.C.ll.i; A.315.C.lLi; A.316.C.ll.i; A.317.C .ll.i; A.318.C.ll.i; A.319.C.lli; A.320.C.ll.i; A.321.C.1U; A.323.C.ll.i ; A.324: C.ll.i; A.325.C.ll.i; A.326.C.ll.i; A.327.C.ll.i; A.328.C.ll.i ; A.329.C.ll.i; A.33〇.C.ll.i; A.331.C.ll.i; A.332.C.1U; A.333.C.ll.i; A.334.C.ll.i; A.335.C.1U; A.336.C.ll.i; A.337.C.ll.i; A.338-C.ll.i; 3 | 3 A.339.C.1U; A.340.C.ll.i; A.341.C.ll.i; A.342.C.ll.i; A.343.C.ll.i; A .344.C.ll.i; A.345.C.ll.i; A.346.C.ll.i; A.347.C.ll.i; A.348.C.ll.i; A .349.C.ll.i; A.350.C.ll.i; A.351.C.ll.i; A.352.C.ll.i; A.353.C.ll.i; A .354.C.ll.i; A.355.C.ll.i; A.356.C.ll.i; A.357.C.ll.i; A.358.C.ll.i; A .359.C.lli; A.360.C.1U; A.361.C-ll.i; A.362.C.ll.i; A.363.C.11.1; A.364.C.1U ; A.365.C.ll.i; A.366.C.ll.i; A.367.C.ll.i; A.368.C.ll.i; 3 $ A.369.C.ll .i; A.370.C.1U; A371.C.ll.i; A.372.C.ll.i; A.373.C.ll.i; A.374.C.ll.i;

A.375.C.ll.i; A.376.C.1U; A.377.C.ll.i; A.378.C.ll.i; A.379.C.ll.i; A. 380.C.ll.i; A.381.C.ll.i; A.382.C.ll.i; A.383.C .: ll.i; A.3S4.C.1U; A. 385.C.ll.i; A.386.Cll.i; A.387.C.ll.i; A.388.C.1U; A.389.C.1U; A.39〇.C.ll .i; A.391.C.ll.i; A.392.Cll.i; A.393.C.ll.i; A.394.C.ll.i; A.395.C.ll.i ; A.396.C.ll.i; A.397.C.ll.i; A.398.CUi; A.399.C.ll.i; A.400.Cll.i; A.401.C1U ; A.402.C.ll.i; A.403.C.ll.i; A.404.C.ll.i; A.405.C.ll.i; A.406.C.1U; A .407.C.ll.i; A.408.C.lLi; A.409.C.ll.i; A.41〇.C.ll.i; A.411.C.ll.i; A. 412.C.ll.i; A.413.C.ll.i; A.414.C.ll.i; A.415.C.ll.i; A.416.C.11.I; A. 417.C.ll.i; A.418.C.ll.i; A.419.C.ll.i; A.420.C.ll.i; A.421.C.ll.i; A. 422.C.ll.i; A.423.C.ll.i; A.424.C.ll.i; A.425.C.1U; A.426.C.ll.i; A.427. C.ll.i; A.428.C.ll.i; A.429.C.ll.i; A.430.C.ll.i; A.431.C.ll.i; A.432. C.ll'.i; A.433.C.1U; A.434.C.ll.i; A.435.C.ll.i; A.436.Cni; A.437.C.ll.i ; A.438.C.ll.i; A.439.C.11.1; A.440.C.ll.i; A.ai.C.ll.i; A.442.C.ll.i; A .443.C.ll.i; A.444.C.ll.i; A.445.C.ll.i; A.446, C.ll.i ; A.447.CJl.i; A.448.C11.1; A.449.C.1U; A.450.C.ll.i; A.451.C.11.X; A.452.C .1U -167---------- 1 ^ .------ IT ------ ^ J (Please read the note on the back before finishing this page) _ Ministry of Economy Printed by Zhongluo Bureau of Shellfisher Consumer Cooperative Γ 4 2 6 6 6 3;: Α7 Β7 _'__ V. Description of Invention (165) A.453.C.ll.i; A.454.C.ll. i; A.455.C.ll.i; A.456.C.ll.i; A.457.C.ll.i; A.458.C.ll.i; 'A.459.C.ll .i; A.460.C.11.1; A.461.C.1U; A.462.C.ll.i; A.463.C.ll.i; A.464.C.ll.i; A .465.C.1U; A.466.C.ll.i; A.467.C.ll.i; A.468.C.ll.i; A.469.C.11.1; A.470.CUi ; A.471.CHi; A.472.C.ll.i; .A.473.C.ll.i; A.474, C.ll.i; A.475.C.ll.i; AA76. C.IU; 5 A.477.C.1U; A.478.Cll.i; A.479.C.ll.i; A.480.C.ll.i; A.481.C.ll.i ; A.4S2.C.ll.i; A.4S3.C.1U; A.484.C.ll.i; A.485.C.11.1; A.486.C.ll.i; A.487 .C.ll.i; A.488.C.ll.i; A.489.C.11.1; A.490.C.ll.i; A.491.C.ll.i; A.492.C .ll.i; A.493.C.ll.i; A.494.C.ll.i; A.495.C.ll.i; A.496.C.ll.i; A.497.C .ll.i; A.498.C.ll.i; A.499.C.1U; A.500.C.ll.i; A.501.C.ll.i; A.502.C.ll .i; A.503.C.ll.i; A.504.C.ll.i; A.5〇5.C.ll.i; A.506.C.ll.i; 10 A.507.C.1U; A.508.C.1U; A.509.C.ll.i; A .510.C.1U; A.511.C.ll.i; A.512.C.ll.i; A.512.C.ll.i; A ^ 13.C.ll.i; A.514 .Cll.i; A.515.C.1U; A.516.C.ll.i; A.517.C.ll.i; A.518.C.ll.i; A.519.C.1U ; A.520.C.1U; A.521.C.ll.i; A.522.C.1U; A.523.C.ll.i; A.524.C.1U; A.525.C .ll.i; A.526.C.ll.i; A.527.Cll.i; A.528.C.ll.i; A.529.C.ll.i; A.530.C.ll .i; A.531.C.ll.i; A.532.C.ll.i; A.533.C.1U; A.534.C.1U; A.535.C.ll.i; 15 A.536.C.ll.i; A.537.C.ll.i; A.538.C.ll.i; A.539.C.1U; A.540.C.ll.i; A. 541.C.ll.i; A.542.C.ll.i; A.543.C.ll.i; A.544.C.1U; A.545.C.ll.i; A.546. 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C.ll.i; A.650.C.114; A.651.C.1U; A.652.C.11.X; A.653.C.ll.i; A.654.C.ll. i; A.655.Cni; * 5 A.656.C.ll.i; A.657.C.lLi; A.658.Cll.i; A.659.C.1U; A.660.C. 1U; A.2.D.4.i; A.3.D.4.i; A.4.D.4.1; A.5.D.4.i; A.6.D.4.i; A.7.D.4.i; A.9.D.4.1; A.10.D.4.i; A.15.D.4.i; A.100.D.4, i; A. 101.D.4.i; A.102.D.4.i; A.103.D.4.i; A.104.D.4.1; A.105.D.4.i; A.106. D.4.i; A.107.D.4.i; A.108.D.4.i; A.109.D.4.i; A.110.D.4.i; A.lll. DAi; A.112.D.4.i; A.113.D.4.i; A.114.D.4.i; A.115.D.4.i; A.116.D.4. i; A.117.D.4.i;: 0 A.118.D.4.i; A.119.D.4.i; A.120.D.4.i; A.121.D. 4.i; A.122.D.4.1; A.123.D.4.i; A.124.D.4.1; A.125.D.4.i; A.126.D.4.i; A.127.D.4.i; A.128.D.4.i; A.129.D.4.1; A.130.D.4.i; A.131.D.4.i; A. 132.D.4.i; A.133.D.4.1; A.134.D.4.i; A.135.D.4.i; A.136.D.4.i; A.137. D.4.i; A.138.D.4.i; A.139.D.4.i; A.140.D.4.i; A.141.D.4.i; A.142. D.4.i; A.143.D.4.i; A.144.D.4.1; A.145.D.4.i; A.146.D.4.i; A.147.D. 4.L; 5 A.148.D, 4.i; A.149.D.4.i; A.150.D.4.i; A.151.D.4.i; A.l52.D .4.i; A.153.D.4.i; A.154.D.4.i; A. 155.D, 4.i; A.156.D.4.i; A.157.D.4.i; A.158.D.4.i; A.159.D.4.i; A. 160.D.4.i; A.161.D.4.i; A.162.D.4.i; A.163.D.4.i; A.164.D.4.i; A. 165.D.4.i; A.166.D.4.i; A.167.D.4.i; A.168.D.4.i; A.169.D.4.i; A. 170.D.4.i; A.171.D.4.i; This paper size is applicable to China Store Standards (CNS), \ 4 specifications (210X297 public broadcasting) ------------ see ------ 1T ------ ^ (Please read the note on the back of the item before writing &gt; .. write this page) Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs 4, 2 6 6 6 3 ra? B7 __ V. Description of the invention (166) A.172.D.4.i; A.173.D.4.1; A.174.D.4.i; A.175.D.4.i; A.176.D.4.i; ΑΛ77.ΌΛΛ; 'A.17S.D.4.i; A.179.D.4.i; A.180.D.4.i; A.181.D .4.i; A.lS2.D.4.i; A.183.D.4.i; A.184.D.4.i; A.lS5.D.4.i; A.186.D .4.i; A.lS7.D.4.i; A.188.D.4.i; A.189.D.4.i; A.190.D.4.i; A.191.D .4.i; A.192.D.4.i; A.193.D.4.i; A.194.D.4.i; A.195.D.4.1; 5 A.196.D. 4.i; A.197.D.4.i; A.198.D.4.i; A.199.D.4.1; A.200.D.4.i; A.201.D.4. i; A.202.D.41; A.203.D.4.i; A.204.D.4.1; A.205.D.4.1; A.206.D.4.i; A.207. D.4.i; A.208.D.4.i; A.209.D.4.i; A.210.D.4.i; A .211.D.4.i; A.212.D.4.i; A.213.D.4.1; A.214.D.4.1; A.215.D.4.i; A.216.D .4.i; A.217.D.4.1; A.218.D.4.i; A.219.D.4.i; A.220.D.4.i; A.221.D.4 .i; A.222.D.4.i; A.223.D.4.i; A.224.D.4.i; A.225.D.4.i; 0 A.226.D. 4.i; A.227.D.4.i; A.228.D.4.i; A.229.D.4.i; A.230.D.4.i; A.231.D. 4.i; A.232.D.4.i; A.233.D.4.i; A.234.D.4.i; A.235.D.4.i; A.236.D. 4.i; A.237.D.4.i; A.238.D.4.i; A.239.D.4.i; A.240.D.4.i; A.241.D. 4.i; A.242.D.4.i; A.243.D.4.i; A.244.D.4.i; A.245.D.4.i; A.246.D. 4.1; A.247.D.4.i; A.248.D.4.i; A-249.D.4.1; A.250.D.4.i; A.251.D.4.i; A.252.D.4.i; A.253.D.4.i; A.254.D.4.i; A.255.D.4.i; 15 A.256: D.4.i ; Α.257.ΌΛ1; A.258.D.4.i; A.259.D.4.i; A.260.D.4.i; A.261.D.4.i; A.262 .D.4.1; A.263.D.4i; A.264.D.4.i; A.265, D.4.i; A.266.D.4.i; A.267.D.4 .i; A.268.D.4.i; A.269.D.4.i; A.270.D.4.i; A.271.D.4.i; A.272.D.4 .i; A.273.D.4.i; A.274.D.4.i; A.275.D.4.i; A.276.D.4.i; A.277.D.4 .i; A.278.D.4.i; A.279.D.4.i; A.280.D.4.i; A.281.D.4.i; A.282.D.4 .i; A.283.D.4.i; A.284.D.4.i; A.285.D.4, i; 20 A.286. 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4266 6 3 A7 B7 Employees' cooperation with the Central Bureau of Standards of the Ministry of Economic Affairs, printed by the agency V. Description of the invention (167) A.461.D.4.i; A.462.D.4.i; A.463.D .4.i; A.464.D.4.i; A.465.D.4.i; A.466.D.4.i; 'A.467.D.4.i; A.468. D.4.i; A.469.D.4.i; A.470.D.4.i; A.471.D.4.i; A.472.D.4.i; A.473. D.4.i; A.474.D.4.i; ΑΛ75.ΌΛ.Ϊ; ΑΛ76.ΌΛΛ; AA77.DA: i; ΑΛ78.ΌΛΛ; A.479.D.4.i; A.480. D.4-.i; A.4Sl.D.4.i; A.4S2.D.4.I; A.4S3.D.4.i; A.484.D.4.i; 5 A. 485.D.4.i; A.486.D.4.i; A.487.D.4.i; A.488.D.4.i; A.489.D.4.i; A. 490.D.4.1; A.491.D.4.i; A.492.D.4.i; A.493.D.4.i; A.494.D.4.i; A.495. D.4.1; A.496.D.4.i; ΑΛ97.ΌΑΛ; A.49S.D.4.i; A.499.D.4.i; A.500.D.4.i; A. 501.D.4.i; A.502.D.4.i; A.503.D.4.i; A.504.D.4.i; A.505.D.4.i; A. 506.D.4.i; A.507.D.4.i; A.508.D.4.i; A.509.D.4.i; A.510.D.4.i; A. 511.D.4.i; A.512.D.4.i; A.512.D.4.i; A.513.D.4.1; 10 A.514.D.4.i; A.515 .D.4.i; A.516.D.4.i; A.517.D.4.i; A.518.D.4.i; A.519.D.4.i; A.520 .D.4.i; A.521.D.4.i; A.522.D.4.i; A.523.D.4.i; A.524.D.4.i; A.525 .D.4.i; A.526.D.4.i; A.527.D .4.i; A.528.D.4.i; A.529.D.4.i; A.530.D.4.i; A.531.D.4.i; A.532.D .4.i; A.533.D.4.i; A.534.D.4.i; A.535.D.4.i; A.536.D.4.i; A.537.D .4.i; A.538.D.4.i; A.539.D.4.i; A.540.D.4i; A.541.D.4.i; A.542.D.4.1 ; A.543.D.4.1; 15 A.544.D.4.i; A.545.D.4.1; A.546.D.4.i; A.547.D.4.i; A. 548.D.4.i; A.549.D.4.i; A.550.D.4.i; A.551.D.4.i; A.552.D.4.i; A. 553.D.4.i; A.554.D.4.i; A.555.D.4.i; A.556.D.4.i; A.557.D.4.1; A.558. D.4.i; A.559.D.4.i; A.560.D.4.i; A.561.a4.i; A.562.D.4.i; A.563.D. 4.i; A.564.D.4.i; Α.565.ΌΛΛ; A.566.OU; A.567.D.4.i; A.568.D.4.i; A.569. D.4.i; A.570.D.4.i; A.571.D.4.i; A.572.D.4.i; A.573.D.4.i; 10 A.574 .D.4.i; A.575.D.4.i; A.576.D.4.I; A.577.D.4.i; A.578.D.4.1; A.579.D .4.1; A.580.D.4.i; A.581.D.4.i; A.5S2.D.4.i; A.583.D.4.i; A.584.D.4 .i; A.585.D-4.i; A.586.D.4.i; A.587.D.4.1; A.588.D.4.i; A.589.D.4.i ; A.590.D.4.i; A.591.D.4.i; A.592.D.4.i; A.593.D.4.i; A.594.D.4.i ; A.595.D.4.i; A.596.D.4.i; Α.597.ΌΛΑ; A.598.D.4.i; A.599.D.4.i; A.600 .D.4.i; A.601.D.4.i ; A.602.D.4.i; A.603.D.4.i; Ϊ5 A.604.D.4.i; A.605.D.4.i; A.606.D.4. i; A.607.D.4.i; A.608.D.4.i; A.609.D.4.i; A.610.D.4.i; A.611.D.4. i; A.612.D.4.i; A.613.D.4.1; A.614.D.4.i; A.615.D.4.i; A.616.D.4.i; A.617.D.4.i; A.618.D.4.i; A.619.D.4.i; A.620.D.4.i; A.621.D.4.i; A.622.D.4.i; A.623.D.4.i; A.624, D.4.i; A.625.D.4.i; A.626.D.4.i; A.627.D.4.i; A.628.D.4.1; A.629.D.4.i; A.630.D.4.i; A.631.D.4.i; A. 632.D.4.i; A.633.D.4.i;: W A.634.D.4.I; A.635.D.4.i; A.636.D.4.i; A.637.D.4.i; A.638.D.4.1; A.639.D.4.i; A.640.D.4.i; A.64! .D.4.i; A. .642.D.4.1; A.643.D.4.i; A.644.D.4.i; A.645.D.4.i; A.646.D.4.i; A.647 .D.4.i; A.648.D.4.i; A.649.D.4.i; A.650.D.4.i; A.651.D.4.i; A.652 .D.4.i; A.653.D.4.i; A.654.D.4.i; A.655.D.4.i; A.656.D.4.i; A.657 .D.4.i; A.658.D.4.i; A.659, D.4.i; A.660.D.4.i; A.2.D.11.1; A.3.D .1U; A.4.D.ll.i; ASDll.i; AeDll.i; A.7.D.ll.i; A.9.D.ll.i; A.IO.D.ll .i; A.15.D.ll.i; A.IOO.D.ll.i; A.IOl.D.ll.i; A.102.D.ll.i; A.103.D.ll .i; A.104.DUi; A.105.D.ll.i; A.106.D.11.1; A.107.D .ll.i; A.108.D.ll.i; A.109.D.ll.i; A.llO.D.ll.i; A.lll.D.ll.i; A.112.D .ll.i; A.113.D.ll.i; A.114.D.ll.i; A.llS.D.ll.i; A.116.D.ll.i; A.117.D .ll.i; A.119.D.ll.i; A.120.D.ll.i; A.lZl.D.ll.i; A.122.D.ll.i; A.123.D .11.1; A.124.D.ll.i; A.125.D.ll.i; A.126.D.1U; A.127.D.ll.i; A.128.D.ll.i ; A.129.D.ll.i; A.130.D.ll.i; A.131.D.1U; A.132.D.ll.i; A.133.D.ll.i; A .134.D.ll.i; A.135.D.1U; A.136.D.ll.i; A.137.D, ll.i; A.13S.D.ll.i; A.139 .D.ll.i; A.140.D.ll.i; A.Ul.D.ll.i; A.142.D.ll.i; A.143.D.ll.i; A.144 .D.ll.i; A.145.D.ll.i; A.146.D.ll.i; A.147.D.ll.i; A.14S.D.ll.i; A.149 .D.ll.i; A.150.D.ll.i; A.151.D.11.1; A.152.D.ll.i; A.153.D.1U; A.154.D.ll .i; 45 A.155.D.ll.i; A.156.D.ll.i; A.157.D.ll.i; A.158.D.ll.i; A.159.D. 1U; A.160.D.ll.i; A.161.D.ll.i; A.162.D.ll.i; A.163.D.ll.i; A.164.D.lli; A.165.D.1U; A.166.D.ll.i; A.167.D.ll.i; A.16S.D.ll.i; A.169.D.ll.i; A. ITO.D.ll.i; A.171.D.1U; A.172.Dni; A, 173.D.ll.i; A.l74.D.ll.i; A.175.D.ll. i; A.176.D.ll.i; A.177.D.1U; A.178.D.1U; please hear η first Note

* The size of the binding paper conforms to the national standard (CNSM4 specification (UKM7 public waste) _ uo _ 42666 3, g. 5. Description of invention (16S) 10 15 20 25 35 Printed by the Consumer Cooperative of the China Standards Bureau of the Ministry of Economic Affairs 40 ¢ 5 A.179.D.ll.i; A.180.D.ll.i; A.ISl.D.ll.i; A.182.D.ll.i; A.lS3.D.ll.i; A.184.D.ll.i A.185.D.ll.i; A.186.D.ll.i; A.187.D.ll.i; A.188.D.ll.i; A .189.D.ll.i; A.190.D.ll.i Α.191.Ό.Π.Ϊ; A.192.D.ll.i; A.193.D.1U; A.194. D.ll.i; A.195.D.ll.i; A.196.D.ll.i A.197.D.ll.i; A.198.D.ll.i; A.199.D .ll.i; A.200.D.ll.i; A.201.D.11.X; A.202.D.ll.i A.203.D.ll.i; A.204.D. ll.i; A.205.D.ll.i; A.206.D.ll.i; A.207.D.ll.i; A.208.D.ll.i A.209.DUi ; A.210.D.ll.i; A.211.D.ll.i; A.212.D.1U; A.213.D.ll.i; A.214.D.1H A.215. D.ll.i; A.216.D.1U; A.217.D.ll.i; A.218.D.ll.i; A.219.D.ll.i; A.220.D. ll.i A.221.D.1U; A.222.D.ll.i; A.223.D.ll.i; A.224.D.ll.i; A.225.D.ll.i ; A.226.D.ll.i A.227.D.11.X; A.228.D.ll.i; A.229.D.ll.i; A.230.D.ll.i; A.231.D.1U; A.232.D.ll.i A.233.D.ll.i; A.234.D.ll.i; A.235.D.ll.i; A.236 .D.ll.i; A.2 37.D.1U; A.238.D.11.1 A ^ 39.D.ll.i; A.240.D.ll.i; A.241.D.ll.i; A.242.D.ll .i; A.243.D.ll.i; A.244.D.ll.i A.245.D.ll.i; A.246.D.11.1; A.247.D.11.X; A.248.D.ll.i; A.249.D.ll.i; A.250.D.ll.i A.251.D.ll.i; A.252.D.ll.i; A .253.D.ll.i; A.254.D.ll.i; A.255.D.1U; A.256.D.ll.i A.257.D.ll.i; A.258. D.ll.i; A.259.D.ll.i; A.260.D.11.I; A.261.D.ll.i; A.262.D.ll.i A.263.D .ll.i; A.264.D.1U; A.265.D.ll.i; A.266.D.ll.i; A.267.D.ll.i; A.268.D.ll .i A.269.D.ll.i; A.270.D.1U; A.271.D.ll.i; A.272.D.llj; A.273.D.ll.i; A. 274.D.1U A.275.D.ll.i; A.276.D.ll.i; A.277.D.ll.i; A.278.D.ll.i; A.279.D .1U; A.280.D.ll.i A.281.D.ll.i; A.282.D.ll.i; A.283.D.ll.i; A.284.D.ll. i; A.285.D.ll.i; A.286.D.ll.i A.287.D.ll.i; A.288.D.ll.i; A.289.D.1U; A .290.D.ll.i; A.291.D.ll.i; A.292.D.ll.i A.293.D, ll.i; A.294.D.1U; A.295. D.ll.i; A.296.D.ll.i; A.297.D.ll; i; A.298.D.1U A.299.D.1U; A.300.D.1U; A .301.D.11.1; A.302.D.ll.i; A.303.D.ll.i; A.304.D.ll.i A.305.D.ll.i; A.306. D.1U; A.307.D.ll.i; A.308.D.ll.i; A.309.D.ll.i; A.310.D.ll. i A.311.D.ll.i; A.312.D.ll.i; A.313.D.1U; A.314.D.ll.i; A.315.D.ll.i; A .316.D.1U A.317.D.1U; A.318.D.1U; A.319.D.ll.i; A.320.D.ll.i; A.321.D.ll. i; A.323.D.ll.i A.324.D.1U; A.325.D.ll.i; A.326.D.11.1; A.327.D.1U; A.328.D .ll.i; A.329.D.ll.i A.330.D.ll.i; A.33l.D.ll.i; A.332.D.ll.i; A.333.D. ll.i; A.334.D.ll.i; A.335.D.ll.i A.336.DHi; A.337.D.ll.i; A.338.D.11.1; A.339 .D.ll.i; A.340.D.1U; A.341.D.ll.i A.342.D.11.1; A.343.D.ll.i; A.344.D.ll. i; A.345.D.1U; A.346.D.ll.i; A.347.D.1U A.348.D.ll.i; A349.D.1U; A.350.D.1U A.351.D.1U; A.352.D.ll.i; A.353.D.ll.i A.354.D.ll.i; A.355.D.ll.i; A. 356.D.ll.i; A.357.D.11.1; A.358.D.ll.i; A.359.D.ll.i A.360.D.ll.i; A.361.D .ll.i; A.362.D.ll.i; A.363.D.ll.i; A.364.D.ll.i; A.365.D.ll.i A.366.D. ll.i; A.367.D.ll.i; A.368.D.ll.i; A.369.DUi; A.370.D.ll.i; A.371.D.ll.i A .372.D.ll.i; A.373.D.ll.i; A.374.D.ll.i; A.375.D.ll.i; A.376.D.ll.i; A .377.D.ll.i A.37S.D.ll.i; A.379.DUi; A.38〇.D.ll.i; A.381.D.ll.i; A.382.D .ll.i; A.383.D.ll.i A.384.D.ll.i; A.385.D. ll.i; A.386.D.ll.i; A.3S7.D.ll.i; A.388.D.ll.i; A.389.D.ll.i A.390.D.1U A.391.D.11.1; A.392.D.1U; A.393.D.ll.i; A.394.D.ll.i; A.395.D.ll.i A.396. D.ll.i; A.397.D.ll.i; A.398.D.ll.i; A.399.D.ll.i; A.400.D.ll.i; A.401. D.ll.i A.402.D.1U; A.403.D.ll.i; A.404.D.ll.i; A.405.D.11J; A.406.D.ll.i ; A.4〇7.D.ll.i, A.408.D.ll.i; A.409.D.ll.i; A.410.D.ll.i; A.411.D.ll .i; A.412.D.ll.i; A.413.D.ll.i A.414.D.ll.i; A.415.D.ll.i; A.416.D.1U; A.417.D.ll.i; A.418.D.ll.i; A.419.D.l'l.i A.420.D.1U; A.421.D.1U; A.422 .D.ll.i; A.423.D.ll.i; A.424.D.ll.i; A.425, D.ll.i A.426.D.1U; A.427.D. ll.i; A.428.D.ll.i; A.429.D.ll.i; A.430.D.ll.i; A.431.D.ll, i A.432.DUi; A .433.D.ll.i; A.434.D.ll.i; A.435.D.ll.i; A.436.D.1U; A.437.D.ll.i A.438. D.1U; A.439, D.ll.i, A.440.D.1U; A.441.D.ll.i; A.442.D.lLi; A.443.D, ll.i A .444.D.ll.i; A.445.D.ll.i; A.446.DUi; A.447.D.ll.i; A.448.D.1U; A.449.D.ll .i, A.450.DUi; A.451.D.ll.i; A.452, D.ll.i; A.453.DUi; A.454.D.1U; A.455.D.ll .i A.456.D.ll.i; A.457.D.1U; A.458.D.ll.i; A.459.D.1U ; A.460.D.ll.i; A.461.DUi A.462.D.ll.i; A.463.D.ll.i; A.464.D.1U; A.465.D. ll.i; A.466.D.ll.i; A.467.D.ll.i Please read the notes on the back first

The size of the paper is applicable to the Chinese National Standard (CNS) 8-4 specification (2! OX 297 Gongkang) _ 171-^ 5 ^ _§_S_3 _ «_ Ministry of Economic Affairs_Central Bureau of Standards for Off-line Consumer Cooperation Du printed 426663; 5 Description of the invention (169) A.468.D.ll.i; A.469.D.ll.i; A.470.D.ll.i; A.471.D.1U; A.472.D. ll.i; A.473.D.ll.i; A.474.D.ll.i; A.475.D.ll.i; A.476.D.1U; A.477.D.ll. i; A.478.D.ll.i; A.479.D.ll.i; A.480.DUi; A.481.D.ll.i; A.482.D.ll.i; A. 483.D.ll.i; A.484.D.ll.i; A.4S5.D.11.1; A.486.D.1U; A.487.D.ll.i; A.488.D. ll.i; A.489.D.11.1; A.490.D.ll.i; A.491.D.11.1; A.492.D.1U; A.493.D.ll.i; A. 494.D.ll.i; A.495.D.ll.i; A.496.D.ll.i; A.497.D.21.i; A.498.D.ll.i; A. 499.D.ll.i; A.500.D.1U; A.SOl.D.ll.i; A.502.D.1U; A.503.D.1U; A.504.D.1U; A.505.D.ll.i; A.506.D.ll.i; A.507.D.ll.i; A.508.D.ll.i; A.509.D.11J; A. 510.D.ll.i; A.511.DHi; A.512.D.ll.i; A.512.D.1U; A.513.D.ll.i; A.514.D.ll. i; A.515.D.ll.i; A.516.D.ll.i; A.517.D.1U; A.518.D.ll.i; A.519.D.ll.i; A.520.D.11J; A.521.D.1U; A.522.D.ll.i; A.523.D.ll.i; A.524.D.ll.i; A.525. D.ll.i; A .526.D.ll.i; A.527.D.ll.i; A.528.D.ll.i; A.529.D.1U; A.530.D.ll.i; A.53LD .ll.i; A.532.D.1U; A.533.D.ll.i; A.534.D.ll.i; A.535.D.ll.i; A.536.D.ll .i; A.537.D.1U; A.538.D.ll.i; A.539.DUi; A.540.D.ll.i; A.541.D.1U; A.542.D .ll.i; A.543.D.11.1; A.544.D.ll.i; A.545.D.ll.i; A.546.D.ll.i; A.547.D.ll .i; A.548.D.ll.i; A.549.D.ll.i; A.550.D.11.1; A.551.D.1U; A.552.D.ll.i; A .553.D.11.I; A.554.D.ll.i; A.555.D.ll.i; A.556.D.ll.i; A.557.D.1U * A.558 .D.ll.i; A.559.D.ll.i; A.560.D.ll.i; A.561.D.1U; A.562.D41.i; A, 563.D.ll .i; A.564.D.ll.i; A.565.D.ll.i; A.566.D.ll.i; A.567.DUi; A.568.D.ll.i; A .569.D.ll.i; A.570.D.ll.i; A.571.D.1U; Α.572.Ό.11.Ϊ; A.573.D.ll.i; A.574 .D.11.1; A.575.D.1U; A.576.D.ll.i; A.577.D.ll.i; A.578.D.ll.i; A.579.D.ll .i; A.580.D.1U; A.581.D.ll.i; A.582.D.ll.i; A.583.D.ll.i; A.584.D.ll.i ; A.585.D.ll.i; A.586.D.1U; A.587.D.lLi; A.588.D.ll.i; A.589.D.ll.i; A.590 .D.ll.i; A.591.D.ll.i; A.592.D.11.1; A.593.D.ll.i; A.594.D.! Li; A.595.D. ll.i; A.596.D.ll.i; A.597.D.ll.i; A .598.D.ll.i; A.599.D.ll, i; A.600, D.ll.i; A.601.D.ll.i; A.602.D.ll.i; A .603.D.1U; A.604.D.ll.i; A.605.D.ll.i; A.606.D.1U; A.607.D.ll.i; A.608.D .ll.i; A.609.D.ll.i; A.610.DUi; A.611.D.ll.i; A.612.D.ll.i; A.613.D.ll.i ; A.614.D.1U; A.615.D.1U; A.616.D.ll.i; A.617.D.11.1; A.6l8.D.ll.i; A.619.D .ll.i; A.620.D.ll.i; A.62X.D.ll.i; A, 622.D.ll.i; A.623.D.1U; A.624.D.1U ; A.625.D.ll.i; A.626.D.ll.i; A.627.D.ll.i; A-628.D.1U; A.629.D.ll.i; A .630.D.ll.i; A.631.D.ll.i; A.632.D.1U; A.633.D.ll.i; A.634.D.ll.i; A.635 .D.ll.i; A.636.D.1U; A.637.D.ll.i; A.638.D.1U; A.639.D.ll.i; A.640.D.ll .i; A.641.D.ll.i; A.642.D.ll.i; A.643.D.ll.i; A.644.D.ll.i; A.645.D.ll .i; A.646.D.ll.i; A.647.D.ll.i; A.648.D.ll.i; A.649.D.ll.i; A.650.D.11.1 ; A.651.D.ll.i; A.652.D.1U; A.653.D.1U; A.654.D.ll.i; A.655.D.ll.i; A.656 .D.1U; A.657.D.ll.i; A.658.D.ll.i; A.659.D.ll.i; A.660.D.ll.i; Α.2.Ε .4.Ϊ; Α.3.Ε.4.Ϊ; A.4.E.4.1; A.5.E.4.i; Α.6.Ε.4.Ϊ; Α.7.Η.4 .Ϊ; Α.9.Ε.4.Ϊ; Α.10.Ε.4.Ϊ; Α.15.Ε.4.Ϊ; A.100.E.4.i; Α.10Ι .Ε.4.Ϊ; A.102.E.4.i; A.103.E.4.i; A.104.E.4.i; A.105.E.4.i; Α.106 .Ε.4.Ϊ; Α.107.Ε.4.Ϊ; Α.108.Ε.4.Ϊ; A.109.H.4.i; A.ll〇.E.4.i; A. lll.E.4.i; Α.112.Ε4.Ϊ; A.113.H.4.i; Α.114.Ε.4.Ϊ; A.115.E.4.i; Α.116. Ε.4.Ϊ; Α.117.Ε.4.Ϊ; A.118.E.4.i; A.119.E.4.I; A.120.E.4.1; Α.121.Ε. 4.Ϊ; Α.122.Ε.4.Ϊ; A.123.E.4.i; A.124.E.4J; Α.125.Ε.4.Ϊ; Α.126.Ε.4Λ; Α.127.Ε.4.Ϊ; A.12S.E.4.i; Α.129.Ε.4.Ϊ; Α.130.Ε.4.Ϊ; A.131.E.4.i; Α.132.Ε.4.Ϊ; A.133.E.4.i; A.134.E.4.i; Α.135.Ε.4.Ϊ; A.136.E.4.I; A.137.E.4.i; Α.138.Ε.4.Ϊ; Α.139.Ε.4.ί; A.140.E.4.i; Α.141.Ε.4.Ϊ; Α.142.Ε.4.Ϊ; A.143.E.4.i; Α.144.Ε.4.Ϊ; Α.145.Ε.4.Ϊ; Α.146.Ε.4.Ϊ; Α.147.Ε.4.Ϊ; A.14S.E.4.i; Α.149.Ε.4.Ϊ; Α.150.Ε.4.Ϊ; A.151.E.4: .i ; A.152.E.4: .i; Α.153.Ε.4.Ϊ; Α.154.Ε.4.Ϊ; A.155.E.4.i; Α.156.Ε.4. Ϊ; Α.157.Ε.4.Ϊ; A.158.E.4.I; Α.159.Ε.4.Ϊ; A.160.E.4.i; Α.161.Ε.4. Ϊ; Α.162.Ε.4.Ϊ; Α.163.Ε.4.Ϊ; Α.164.Ε.4.Ϊ; Α.165.Ε.4.Ϊ; A.166.E.4. i; Α.167.Ε.4.Ϊ; Α.Ί68.Ε.4.Ϊ; A.169.H.4.i; Α.170.Ε.4.Ϊ; Α.171.Ε.4.Ϊ; A.172.E.4.i; A.173.E.4.i; A.174.E.4.1; A.175.E.4.i; Α.176.Ε.4Λ; Α.177.Ε.4.Ϊ; A.17S.E.4.i; A.179. E.4.1; A.180.E.4.i; 'A.lSl.E.4.i; A.182.E.4.i; A.lS3.E.4.i; A.lS4.E .4.i; A.185.E.4.i; A.l86.E.4.i; This paper size applies to national standard ((: :)) 4 (21 (to 2 ^ 7 dust) ;) _172- 4 266 6 3 A7 B7 V. Description of the invention (170) Printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs

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Description of the invention (17 ^ Α7 Β7 Printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs A.4S4.E.ll.i; A.4S5.E.12.i; A.486.E.ll.i; Α.487.Ε.11.Ϊ; A.488.E.ll.i; Α.489.Ε.Χ1.Ϊ; Α.490.Ε.11.Ϊ; Α.491.Ε.11.Ϊ; A.492.H.ll.i; A.493.E.ll.i; Α.494.Ε.Π.ί; Α.495.Ε.11.Ϊ; A .496.E.ll.i; Α.497.Ε.11.Ϊ; Α.498.Ε.Π.Ϊ; A.499.E.ll.i; A.SOO.E.ll.i; Α .501.E.11.Ϊ; A.502.E.11.1; A.503.H.1U; A.504.E.ll.i; A.505.E.1U; Α.506.ΕΛ1.Ϊ ; A.507.E.1U; A.508.E.1U; Α.509.Ε.11.Ϊ; Α.510.Ε.11.Ϊ; A.Sll.E.ll.i; A.512 .E.1H; Α.512.Ε.11.Ϊ; Α.513.Ε.11.Ϊ; A.514.E.1U; A.515.E.ll.i; Α.516.Ε.1Π ; A.517.E.1U; A.518, E.ll.i; A.519.E.ll.i; Α.520.E.ll.i; A.521.E.ll.i; A .522.E.ll.i; A.523.E.1U; A.524.E.ll.i; A.525.E.1U; A.526.E.1U; Α.527.Ε.Η .Ϊ; Α.528.Ε.11.Ϊ; Α.529.Ε.11.Ϊ; Α.530.ΕΛ1.Ϊ; A.531.E.1U; A.532.E.ll.i; A .533.E.1U; A.534.E.ll.i; A.535.E.1U; A.536.E.ll.i; A.537.E.ll.i; A.538.E .ll.i; Α.539.Ε.11.Ϊ; A.540.E.ll.i; A.541.E.1U; Α.542.Ε.11.Ϊ; Α.543.Ε.11 .Ϊ; Α.544.ΕΛ1.Ϊ; A.545.E.ll.i; Α.546.Ε.1Π; Α.547.ΕΛ1.Ϊ; A.548.E.ll.i; A.549 .E.1U; Α.550.Ε.11.Ϊ; Α.551.Ε.11.Ϊ; Α.552.Ε.11.Ϊ; Α.553.Ε.Π.Ϊ; Α.554.Ε .11.Ϊ; A.555.E.ll.i; A.556.E.ll.i; A.557.E.ll.i; A.558.E.ll.i; Α.559.Ε .11.Ϊ; Α.560.Ε.11.Ϊ; A.561.E.ll.i; Α.562.Ε.11. ; A.563.E.ll.i; Α.564.Ε.11.Ϊ; A.565.E.ll.i; A.566.E.1U; 15 Α567.Ε.11.Ϊ; A. 568.E.1U; A.569.E.ll.i; Α.570.E.11.Ϊ; A.571.E.1U; A.572.E.11.1; Α.573.Ε.11. 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F.4.i; A.148.F.4.i;: 0 A.149, F.4.i; A.150.F.4.i; A.151.F.4.i; A. 152.F.4.i; A.153.F.4.i; A.l54.F.4.i; A.155.F.4.i; A.156.F.4.i; A. 157.F.4.i; A.158.F.4.i; A.159.F.4.i; A.160.F.4.i; A.161.F.4.i; A. 162.F.4.i; A.163.F.4.i; A.164.F.4.i; A.165.F.4.i; A.166.F.4.i; A. 167, F.4.i; A.168.F.4.i; A.169.F.4.i; A.170.F.4.i; A.171.F.4.i; A. 172.F, 4.i; A.173.F.4.i; A.174.F.4.i; A.175.F.4.i; A.176.F.4.i; A. l77.F.4.i; A.178.F.4.i; i5 A.179.F.4.i; A.18〇.F.4.i; A.18l.F.4.i; A.182.F.4.i; A.183.F.4.i; A.184.F.4.i; A.lS5.F.4.i; A.186.F.4.1; A. 187.F.4.i; A.188.F.4.i; A.lS9, F.4.i; A.190.F.4.i; A.191.F.4.i; A. 192.F.4.1; A.193.F.4.i; A.194.F.4.i; A.195.F.4.:; A.196.F.4.i; A.197. F.4.i; A.198.F.4.1; A.199.F.4.i; A.200.F.4.i; A.201.F.4.i; A.202.F. 4.1;. Please read the notes on the back of this paper size Chong Guomin Family Standard (CNS) Λ4 specification (2⑴XW7 male) 176-4 2 6 6 6 3 A7 _4 _B7 V. Description of the invention (174) 5 · .〇: 5: 0 25 33 35 Ministry of Economic Affairs: 40 standard

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Description of the invention (175) A.492.F.4.i; A.493.F.4.i ; A.494.F.4.i; A.495.F.4.i; A.496.F.4.i; A.497.F.4.i; 'A.498.F.4. i; A.499.F.4.i; A.500.F.4.i; A.501.F.4.i; A.502.F.4.i; A.503.F.4.1; A.504.F.4.i; A.505.F.4.i; A.506.F.4.i; A.507.F.4.1; A.508.F.4.i; A. 5〇9.F.4.i; A.510.F.4.1; A.511.F.4.i; A.512.F.4.i; A.512.F.4.i; A. 513.F.4.i; A.514.F.4.i; 5 A.515.F.4.i; A.516.F, 4.i; A.5l7.F.4.i; A .51S.F.4.i; A.519.F.4.i; A.520.F.4.i; A.521.F.4.i; A.522.F.4.i; A .523.F.4.i; A.524.F.4.i; A.525.F.4.1; A.526.F.4.i; A.527.F.4.i; A.528 .F.4.i; A.529.F.4.i; A.530.F.4-i; A.531.F.4.i; A.532.F.4.i; A.533 .F.4.i; A.534.F.4.i; A.535.F.4.i; A.536.F.4.i; A.537.F.4.i; A.538 .F.4.i; A.539.F.4.i; A, 540.F.4.i; A.541.F.4.i; A.542.F.4.1; A.543.F .4.i; A.544.F.4.i; 10 A.545.F.4.i; A.546.F.4.i; A.547.F.4.i; A.548. F.4.i; A.549.F.4.i; A.550.F.4.i; A.551.F.4.i; A.552.F.4.i; A.553. F.4.i; A.554.F.4.i; A.555.F.4.i; A.556.F.4d; A.557.FAA; A.558.F.4.i; A.559.F.4.1; A.560.F.4.i; A.561.F.4.i; A.562.F, 4.i; A'.563.F.4.i; A .564.F.4.i; A.565.F.4.i; A.566.FA.i; A.567.F.4.i; A.568.F. 4.i; A.569.F.4.1; A.570.F.4.i; A.571.F.4.i; A.572.F.4.i; A.573.F.4.1; A.574.F.4.i; 15 A.575.R4.i; Α.576.ΈΑΛ; A.577.F.4.1; A.578.F.4.i; A.579.F.4 .i; A.580.F.4.i; A.581.F.4.i; A.582.F.4.i; A.583.R4.i; A.584.F.4, i ; A.585-F.4.i; A.586.F.4.i; A.587.F.4.i; A.588.F.4.i; A.589.F.4.i ; A.590.F.4.i; A.591.F.4.i; A.592.F.4.i; A.593.F.4.i; A.594.F.4.i A.595.F.4.1; A.596.F.4.i; A.597.F.4.i; A.598.F.4.1; Α.599.ΈΛ.Ϊ; A.600.F .4.i; A.601.F.4.i; A.602.F.4.i; A.603.F.4.i; A.604.F.4.i; 20 A.605. F.4.1; A.606.F.4.i; A.607.F.4.I; A.608.F.4.i; A.609.F.4.i; A.610; F. 4.i; A.611.F.4.i; A.612.iF.4.i; A.613.F.4.i; A.614.F.4.i; A.615.F. 4.I; A.616.F.4.i; A.617.F.4.i; A.618.F.4.i; A.619.F.4.i; A.620.F. 4.i; A.621.F.4.1; A.622.F.4.i; A.623.F.4.i; A, 624.F.4.i; Α.625T.4.Ϊ; A.626.F.4.i; A.627.F.4.i; A.628.F.4.i; A.629.F.4.1; A.630.F.4.i; A. 631.F.4.1; A.632.F.4.i; A.633.F.4.i; A.634.F.4.i; 25 A.635.F.4.i; A.636 .F.4.i; A.637.F.4.i; A.638.F.4.i; A.639.F.4.i; A.640.F.4.i; A.641 .F.4.i; A.642.F.4.1 ; A.643.F.4.i; A.644.F.4.i; A.645.F.4.I; A.646.F.4.i; A.647.F.4.i ; A.648.F.4.i; A.649.F.4.i; A.650.F.4.i; A.651.F.4.i; A.652.F.4.i ; A.653.F.4.i; A.654.F.4.i; A.655.F.4.i; A.656.F.4.i; A.657.F.4.1; A. .658.F.4.i; A.659.F.4.i; A.660.F.4.i; A.2.F.1U; A.3.F.1U; A.4.F .ll.i; A.5.F.ll.i; A.6.F.ll.i;} 〇A.7.F.1U; A.9.F.ll.i; A.10.FUi ; A.15.F.1U; A.100.F.1U; A.101.F.ll.i; A.102.F.ll.i; A.103.F.ll.i; A.104 .F.ll.i; A.IOS.F.ll.i; A.106.F.ll.i; A.107.F.ll.i; A.108.F.ll.i; A.109 .Rll.i; A.llO.F.ll.i; A.lll.F.ll.i; A.112.F.ll.i; A.113.F.ll.i; A.114.F .ll.i; A.115.F.ll.i; A.116.F.ll.i; A.117.F.ll.i; A.ll8.F.ll.i; A.119.F .ll.i; A.120.F.ll.i; A.121.Rll.i; A.122.F.ll.i; A.123.F.ll.i; A.124.F.1U ; A.125.F.ll.i;! 5 A.126.F.ll.i; A.127.F.ll.i; A.128.F.ll.i; A.129.F.ll .i; A.130.F.1U; A.131.F.ll.i; A.132.F.ll.i; A.133.F.ll'.i; A.134.F.ll. i; A.135.F.11.1; A.136.F.ll.i; A.137.F.ll.i; A.138.F.ll.i; A.139.F.1U; A. 140.F.ll.i; A, 141.F.ll.i; A.142.F.ll.i; A.143.F.ll.i; A.144.F.ll.i; A. 145.F.ll.i; A.146. F.ll.i; A.147.F.ll.i; A.14S.F.ll.i; A.149.F.ll.i; A.ISO.F.ll.i; A.151. F.1U; A.152.F.1U; A.153.F.ll.i; A.154.F.ll.i; A.155.F.ll.i; 0 A.156.F.ll .i; A.157.F.ll.i; A.158.F.1U; A.159.F.ll.i; A.160.F.11.1; A.161.F.ll.i; A .162.F.ll.i; A.163.F.ll.i; A.164.F.ll.i; A.165.F.ll.i; A.166.F.ll.i; A .167.F.ll.i; A.16S.F.ll.i; A.169.F.1U; A.170.F.ll.i; A.171.F.ll.i; A.172 .F.ll.i; A.173.F.ll.i; A.174.F.ll.i; A.175.F.ll.i; A.176.F.lLi; A.177.F .ll.i; A.178.F, ll.i; A.179.F.ll.i; A.180.F.ll.i; A.181.F.ll.i; A.182.F .ll.i; A.183.F.ll.i; A.184.F.ll.i; A.lSS.F.ll.i; 5 A.186.F.ll.i; A.187. F.ll.i; A.lS8.F.ll.i; A.189.F.ll.i; A.190.F.1U; A.191.F.ll.i; A.192.F. ll.i; A.193.F.ll.i; A.l94.F.ll.i; A.195.F.ll.i; A.196.F.ll.i; A.197.F. ll.i; A.198.F.ll.i; A.199.F.1U; A.200.F.ll.i; A.201.F.ll.i; A.202.F.ll. i; A.203.F.ll.i; A.204.Rll.i; A.205.F.1U; A.206.F.1U; A.207.FUi; A.208.F.1U; A.209.F.ll.i; This paper is fully applicable to China National Standards Corporation (CNS) 8 4 square (2 丨 Ox 2 〔; 7mm t) _ us-please ▲ Matters needing attention Printed by the Central Standards Bureau of the Ministry of Economic Affairs, printed by the Shellfish Consumer Cooperative, m 426663 A7 B7 V. Description of the invention (176) Printed by the Central Standards Bureau of the Ministry of Economic Affairs, printed by the Consumers Cooperative of A.210.F.ll.i; A.211. F.ll.i; A.212.F.ll.i; A.214.F.ll.i; A.215.F.ll.i; 'A.216.F.ll.i; A.217 .F.ll.i; A.218.F.ll.i; A.219.F, ll.i; A.220.F.ll.i; A.221.F.1U; A.222.F .1U; A.223.F.ll.i; A.224.F.ll.i; A.225.F.1U; A.226.F.1U; A.227.F.ll.i; A .228.F.ll.i; A.229.F.ll.i; A.230.F.ll.i; A.231.F.ll.i; A.232.F.ll.i; A .233.F.1U; 5 A.234.FUi; A.235.F.ll.i; A.236.F.ll.i; A.237.F.1U; A.238.F.ll. i; A.239.F.ll.i; A.240.F.1U; A.241.F.ll.i; A.242.F.ll.i; A.243.F.ll.i; A.244.F.ll.i; A.245.F.11.1; A.246.F.ll.i; A.247.F.ll.i; A.248.F.ll.i; A. 249.F.1U; A.250.F.ll.i; A.251.F.1U; A.252.F.1U; A.253.F.ll.i; A.254.F.ll. i; A.255.F.11.X; A.256.F.ll.i; A.257.F.ll.i; A.258.F.ll.i; A.259.F.1U; A.260.F.ll.i; A.261.F.ll.i; A.262.F.ll.i; A.263.F.ll.i; 10 A-264.F.ll.i ; A.265.F.ll.i; A.266.FUi; A.267.F.11.:; A.268.F.ll.i; A.269.F.ll.i; A.270 .F.ll.i; A. 271.F.1U; A.272.F.1U; A.273.F.ll.i; A.274.F.ll.i; A.275.F.11.1; A.276.F.1U; A.277.F.ll.i; A.278.F.1U; A.279.F.ll.i; A.2S0.F.ll.i; A.281.F.ll.i; A. 282.F.ll.i; A.283.F.ll.i; A.284.F.ll.i; A.285.F.1U; A.286.F.1U; A.287.F. ll.i; A.288.F.ll.i; A.289.F.ll.i; A.290.F.1U; A.291.F.ll.i; A.292.F.ll. i; A.293.F.ll.i; 15 A.294.F.ll.i; A.295.F.ll.i; A.296.F.ll.i; A.297.F.ll .i; A.298.F.ll.i; A.299.F.ll.i; A.300.F.ll.i; A.301.F.ll.i; A-302.F.ll .i; A.303.F.ll.i; A.304.F.11.1; A.305.F.1U; A.306.F.ll.i; A.307, F.ll.i; A .308.F.1U; A.309.F.ll.i; A.310.F.ll.i; A.311.F.ll.i; A.312.F.ll.i; A.313 .F.ll.i; A.314.F.ll.i; A.315.F.ll.i; A.316.F.ll.i; A.317.F.ll.i; A.318 .F.ll.i; A.319.F.ll.i; A.320.F.ll.i; A.321.F.ll.i; A.323.F.ll.i; A.324 .F.ll.i; 20 A.325.F.ll.i; A.326.FHi; A.327.F.1U; A.328.F.ll.i; A.329.F.1U; A.330.F.ll.i; A.331.F.ll.i; A.332.F.ll.i; A.333.F.ll.i; A.334.F.ll.i; A.335.F.ll.i; A.336.F.ll.i; A.337.F.1U; A.338.F.1U; A.339.F.ll.i; A.340. F.ll.i; A.341.F.ll.i; A342.F.ll.i; A.343.F.ll.i; A.344.F.ll .i; A.345.F.ll.i; A.346.F.ll.i; A.347.F.ll.i; A.348.F.ll.i; A.349.F.1U ; A.350.F.ll.i; A.351.F.ll.i; A.352.F.ll.i; A.353.F.ll.i; A.354.F.ll.i ; 25 A.355.F.ll.i; A.356.F.1U; A.357.F.ll.i; A.358.FUi; A.359.F.ll.i; A.360. F.1U; A.361.F.ll.i; A.362.F.ll.i; A.363.F.ll.i; A.364.F.1U; A.365.F.ll. i; A.366.F.ll.i; A.367.F.ll.i; A.368.F.ll.i; A.369.F.ll.i; A.370.F.ll. i; A.371.F.ll.i; A.372.F.ll.i; A.373.F.ll.i; A.374.F.11.1; A375.F.ll.i; A. 376.F.ll.i; A.377.F.ll.i; A.378.F.1U; A.379.F.ll.i; A.380.F.1U; A.381.F. ll.i; A.382.F.ll.i; A.383.F.ll.i; A.384.F.ll.i; A.3S5.F.ll.i; A.386.F. ll.i; A.387.F.ll.i; A.388.F.ll.i; A.389.F.ll.i; A.390.F.ll.i; A.391.F. ll.i; A.392.F.11.1; A.393.F.ll.i; A.394.F.ll.i; A.395.F.ll.i; A.396.F.ll. i; A.397.F.ll.i; A.398.F.ll.i; A.399.F.ll.i; A.400.F.ll.i; A.401.F.ll. i; A.402.F.1U; A.403.F.ll.i; A.404.F.ll.i; A.405.F.Xl.i; A.406.F.1U; A. 407.F.ll.i; A.408.F.1U; A.409.F.ll.i; A.410.F.ll.i; A.411.F.ll.i; A.412. F.1U; A.413.F.ll.i; A.414.F.ll.i; A.415.F.ll.i; A.416.F.ll.i; A.4 17.F.1U; A.418.F.ll.i; A.419.F.1H; A.420.F.ll.i; A.421.F.ll.i; A.422.F. ll.i; A.423.F.ll.i; A.424.F.ll.i; A.425.F.ll.i; A.426.F.ll.i; A.427.F. 1H; A.428.FUi; A.429.F.ll.i; A.430.F.ll.i; A.431.F.ll.i; A.432.F.ll.i; A. 433.F.ll.i; A.434.F.ll.i; A.435.F.ll.i; A.436.F.ll.i; A.437.F.ll.i; A. 438.F.ll.i; A.439.F.ll.i; A.440.F.ll.i; A.441.F.ll.i; A.442.F.ll.i; A. 443.F.ll.i; A.444.F.Il.i; ί0 A.445.F.ll.i; A.446.F.ll.i; A.447.F.1U; A.448 .FUi; A.449.F.1U; A.450.F.ll.i; A.451.F.ll.i; A.452.F.ll.i; A.453.FUi; A.454 .F.ll.i; A.455.F.ll.i; A.456.F.ll.i; A.457.FUi; A.458.F.ll.i; A.459.F.ll .i; A.460.F.1U; A.461.F.ll.i; A.462.F.ll.i; A.463.FUi; A.464.F.ll.i; A.465 .F.ll.i; A.466.F.ll.i; A.467.F.1U; A.468.F.ll.i; A.469.F.ll.i; A.470.F .ll.i; A.471.F.ll.i; A.472.F.ll.i; A.473.F.1U; A.474.F.ll.i; 45 A.475.F. 1U; A.476.F.ll.i; A.477.F.1U; A.47S.F.1L1; A.479.F.1U; A.480.F.ll.i; A.481. F.lLi; A.482.F.1U; A.483.F.ll.i; A.484.F.ll.i; A.485.F.ll.i; A.486.F.11. :; A.487.F.ll.i; A.488.F.ll.i; A.489.F .ll.i; A.490.F.1U; A.491.F.ll.i; A.492.F.ll.i; A.493.F.ll.i; A.494.F.1U ; A.495.F.ll.i; A.496.F.ll.i; A.497.F.1U; A.498.F, ll.i; Note of reading and reading Φ item and t binding This paper size applies to China National Standards (CNS) / VUUM 210X 297 Gongcheng) -179-V: 426663,-, Invention Description (m) A.499.F.ll.i; A.500.F.ll. i; A.SOl.F.ll.i; A.502.FUi; A.503.F.1U; A.504.F.ll.i; A.505.F.ll.i; A.506. F.ll.i; A.507.Fni; A.508.F.ll.i; A.509.F.ll.i; A.510.F.ll.i; A.511.F.ll. i; A.512.F.1U; A.512.F.ll.i; A.513.F.ll.i; A.514.F.ll.i; A.515.F.ll.i; A.516.F.ll.i; A.517.F.ll.i; A.518.F.ll.i; A.519.F.1U; A.520.F.ll.i; A. 521.F.ll.i; 5 A.522.F.1U; A.523.F.ll.i; A.524.F.ll.i; A.525.F.ll.i; A.526 .F.ll.i; A.527.F.ll.i; A.528.F.ll.i; A.529.F.1U; A.530.F.1U; A.531.F.ll .i; A.532.F.ll.i; A.533.F.1U; A.534.F.1U; A.535.F.1U; A.536.F.ll.i; A.537 .FU :; A.538.F.ll.i; A.539.F.ll.i; A-540.F.ll.i; A.541.F.ll.i; A.542.F. 1H; A.543.F.1U; A.544.F.1U; A.545.F.ll.i; A.546.F.ll.i; A.547.F.ll.i; A. 548.F.ll.i; A.549.F. 11.1; A.550.F.ll.i; A.551.F.ll.i; 10 A.552.F.ll.i; A.553.F.ll.i; A.554.F.1U ; A.555.F.1U; A.556.F.ll.i; A.557.F.ll.i; A.558.F.ll.i; A.559.F.ll.i; A. .560.F.1U; A.561.F.11.X; A.562.F.ll.i; A.563.F.ll.i; A.564.F.ll.i; A.565 .F.ll.i; A.566.F.ll.i; A.567.F.ll.i; A.568.F.ll.i; A.569.F.11.X; A.570 .F.11.1; A.571.F.1U; A.572.F.1U; A.573.F.1U; A.574.F.ll.i; A.575.F.ll.i; A .576.F.1U; A.577.F.ll.i; A.578.F.ll.i; A.579.F.ll.i; A.580.F.ll.i; A.581 .Rll.i; tl5 A.582.F.1U; A.583.F.1U; A.584.F.1U; A.585.F.ll.i; A.586.F.11.I; A.587.F.ll.i; A.588.F.1U; A.589.F.ll.i; A.590.F.1U; Α.591.ΕΠ.ί; A.592.F. ll.i; A.593.F.ll.i; A.594.F.ll.i; A595.F.1U; A.596.F.ll.i; A.597.F.ll.i; A.598.F.ll.i; A.599.F.ll.i; A.600.F.ll.i; A.601.F.1U; A.602.F.ll.i; A. 603.F.ll.i; A.604.F.ll.i; A.605.F.ll.i; A.606.F.ll.i; A.607.F.ll.i; A. 608.F.ll.i; A.609.F.1U; A.610.F.1U; A.611.F.ll.i; IQ A.612.F.1U; A.613.F.1U ; A.614.F.ll.i; A.615.F.ll.i; A.616.F.ll.i; A.6l7.F.ll.i; A.618.F.ll.i ; A.619.F.lLi; A.620.F.ll.i; A.621.F.ll.i; A.622.F.ll.i; A.623.F.ll.i; A.624.F.ll.i; A.625.F.1U; A.626.F.ll.i; A. 627.F.ll.i; A.628.F.ll.i; A.629.F.ll.i; A.630.F.ll.i; A.631.F.1U; A.632. 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Description of the invention (178) 5 5 -S- Deduction 5 Economy The staff of the Central Standards Bureau of the Ministry of Foreign Affairs cooperated and printed 4 A.221.a.44.i; A.222.a.44.i; A.223.a.44.i; A.224.a.44. i; A.225.a.44.i; A.226.a.44.i A.227.a.44.i; A.228.a.44.i; A.229.a.44.i ; A.230.a.44.i; A.231.a.44.i; A.232.a.44.i A.233.a.44.i; A.234.a.44.i; A.235.a.44.i; A.236.a.44.i; A.237.a.44.i; A.238.a.44.i A.239.a.44.i; A .240.a.44.i; A.241.a.44.i; A.242.a.44.i; A.243.a.44.i; A.244.a.44.i A. 245.a.44.i; A.246.a.44.i; A.247.a.44.i; A.24 8.a.44.i; A.249.a.44.i; A.250.a.44.i A.251.a.44.i; A.252.a.44.i; A.253 .a.44.i; A.254.a.44.i; A.255.a.44.i; A.256.a.44.i A.257.a.44.i; A.258. a.44.i; A.259.a.44.i; A.260.a.44.i; A.261.a.44.i; A.262.a.44.i A.263.a .44.z; A.264.a.44.i; A.265.a.44.i; A.266.a.44.i; A.267.a.44.i; A.268.a .44.i A.269.a.44.i; A.270.a.44.i; A.271.a.44.i; A.272.a.44.i; A.273.a. 44.i; A.274.a.44.i A.275.a.44.i; A.276.a.44.i; A.277.a.44.i; A.278.a.44 .i; A.279.a.44.i; A.280.a.44i A.281.a.44.i; A.282.a.44.i; A.283.a.44.i; A.284.a.44.i; A.285.a.44.i; A.286.a.44.i A.287.a.44.i; A.288.a.44.i; A .289.a.44.i; A.290.a.44.i; A, 291.a.44.i; A.292.a.44.i A.293.a.44.i; A. 294.a.44.i; A.295.a.44.i; A.296.a.44.i; A.297.a.44.i; A.298.a.44.i A.299 .a.44.i; A.300.a.44.i; A.301.a.44.i; A.302.a.44.i; A.303.a.44.i; A.304 .a.44.i A.305.a.44.i; A.306.a.44.i; A.307.a.44.i; A.308.a.44.i; A.309. a.44.i; A.310.a.44.i A.311.a.44.i; A.312.a.44.i; A.313.a.44.i; A.314.a .44.i; A.315.a.44.i; A.316.a.44.i A.317.a.44.i; A.318.a.44.i; A.319.a. 44.i; A.3 20.a.44.i; A.321.a.44.i; A.322.a.44.i A.323.a.44.i; A.324.a.44.i; A.325 .a.44.i; A.326.a.44.i; A.327.a.44.i; A.328.a.44.i A.329.a.44.i; A.330. a.44.i; A.331.a.44.i; A.332.a.44.i; A.333.a.44.i; A.334.a.44.i A.335.a .44.i; A.336, a.44.i; A.337.a.44.i; A.338.a.44.i; A.339.a.44.i; A.340.a .44.i, A.341.a.44.i; A.342.a.44.i; A.343.a.44.i; A.344.a.44.i; A.345.a , 44.i; A.346.a.44.i A.347.a.44.i; A.348.a.44.i; A.349.a.44.i; A.350.a. 44.i; A.351.a.44.i; A.352.a.44.i A. 353.a.44.i; A.354.a.44.i; A.355.a.44 .i; A.356.a.44.i; A.357.a.44.i; A.358.a.44i, B. 2.a.44.i; B.3.a.44.i ; B.4.a.44.i; B.5.a.44.i; B.9.a.44.i; B.100.a.44.i; B.101.a.44.i ; B.102.a.44.i; B.103.a.44.i; B.104.a.44.i; B.105.a.44.i; B.106.a.44.i ; B.107.a.44.i; B.108.a.44.i; B.109.a.44.i; B.110.a.44.i; B.lll.a.44.i ; B.112.a.44.i; B.113.a.44.i; B.114.a.44.i; B.115.a.44.i; B.116.a.44.i ; B.117.a.44.i; B.118.a.44.i; B.119.a.44.i; B.120.a.44.i; B.121.a.44.i ; B.122.a.44.i; B.123.a.44.i; B.124.a.44.i; B.125.a.44.i; B.126.a.44.i ; B.127.a.44.i; B.128.a.4 4.i; B.129.a.44.i; B.130.a.44.i; B.131.a.44.i; B.132.a.44.i; B.133.a. 44.i; B.134.a.44.i; B.135.a.44.i; B.136.a.44.i; B.137.a.44.i; B.138.a. 44.i; B.139.a.44.i; B.140.a.44.i; B.141.a.44.i; B.142.a.44.i; B.143.a. 44.i; B.144.a.44.i; B.145.a.44.i; B.146.a.44.i; B.147.a.44.i; B.148.a. 44.i; B.149.a.44.i; B.150.a.44.i; B.151.a.44.i; B.152.a.44.i; B.153.a. 44.i; B.154.a.44.i; B.155.a.44.i; B.156.a.44.i; B.157.a.44.i; B.158.a. 44.i; B.159.a.44.i; B.160.a.44.i; B.161.a.44.i; B.162.a.44.i; B.163.a. 44.i; B.164.a.44.i; B.165.a.44.i; B.166.a.44.i; B.167.a.44.i; B.168.a. 44.i; B.169.a.44.i; B.170.a.44.i; B.171.a.44.i; B.172.a.44.i; B.173.a. 44.i; B.174.a.44.i; B.175.a.44.i; B.176.a.44.i; B.177.a.44.i; B.178.a. 44.i; B.179.a.44.i; B.180.a.44.i; B.181.a.44.i; B.182.a.44.i; B.183.a. 44.i; B.184.a.44.i; B.185.a.44.i; B.186.a.44.i; B.187.a.44.i; B.188.a. 44.i; B.189.a.44.i; B.190.a.44.i; B.191.a.44.i; B.192.a.44.i; B.193.a. 44.i; B.194.a.44.i; B.195.a.44.i; B.196.a.44.i; B.197.a.44.i; B.198.a. 44.i; B.199.a.44.i; B.200.a.44.i; B.201.a.44.i; B.202.a.44.i; B.203, a.44.i; B.204.a.44.i; B.205.a.44.i; B.206.a.44.i; B.207.a.44.i; B.208.a.44.i; B.2〇9.a.44. i; B.210.a.44.i; B.211.a.44.i; B.212.a.44.i; B.213.a.44.i; B.214.a.44. i; B.215.a.44.i; B.216.a.44.i; B.217.a.44.i; B.218, a.44.i; B.219.a.44. i; B.220.a.44.i; B.221.a.44.i; B.222.a.44.i; B.223.a.44.i; B.224.a.44. i; B.225, a.44.i; B.226.a.44.i; B.227.a.44.i; B.228.a.44.i; B.229.a.44. i; B.230.a.44.i; B.231.a.44.i; B.232.a, 44.i; B.233.a.44.i; B.234.a.44. i; B.235.a.44.i; B.236.a.44.i; B.237.a.44.i; B.238.a.44.i; B.239.a.44. i; B.240.a.44.i; B.241.a.44.i; B.242.a.44.i; B.243.a.44.i; B.244.a.44. i; B.245.a.44.i; This paper is suitable for the size of the Chinese national standard (CNS) Λ4 size (2U) X297 mm) — 181-^ _W_Ώ_S_5_D-Er 1 2 2 3 3 4 ^ A member of the Bureau of Standards and Consumer Cooperatives, China Dun'4 2 66 6 3 ^. V. Description of the invention (179) B.246.a.44.i; B.247.a.44.i; B.248.a. 44.i; B.249.a.44.i; B.250.a.44.i; B.251.a.44.i; B.252.a.44.i; B.253.a. 44.i; B.254.a.44.i; B.255.a.44 .i; B.256.a.44.i; B.257.a.44.i; B.258.a.44.i; B.259.a.44.i; B.260.a.44 .i; B.261.a.44.i; B.262.a.44.i; B.263.a.44.i; B.264.a.44.i; B.265.a.44 .i; B.266.a.44.i; B.267.a.44.i; B.268.a.44.i; B.269.a.44.i; B.270.a.44 .i; B.271.a.44.i; B.272.a.44.i; B.273.a.44.i; B.274.a.44.i; B.275.a.44 .i; B.276.a.44.i; B.277.a.44.i; B.278.a.44.i; B.279.a.44.i; B.280.a.44 .i; B.281.a.44.i; B.282.a.44.i; B.283.a.44.i; B.284.a.44.i; B.285.a.44 .i; B.286.a.44.i; B.287.a.44.i; B.288.a.44.i; B.289.a.44.i; B.290.a.44 .i; B.29l.a.44.i; B ^ 92.a.44.i; B.293.a.44.i; B.294.a.44.i; B.295.a.44 .i; B.296.a.44.i; B.297.a.44.i; B.298.a.44.i; B.299.a.44.i; B.300.a.44 .i; B.301.a.44.i; B.302.a.44.i; B.303.a.44.i; B.304.a.44.i; B.305.a.44 .i; B.306.a.44.i; B.307.a.44.i; B.308.a.44.i; B.309.a.44.i; B.310.a.44 .i; B.311.a.44.i; B.312.a.44.i; B.313.a.44.i; B.314.a.44.i; B.315.a.44 .i; B.316.a.44.i; B.317.a.44.i; B.318.a.44.i; B.319.a.44.i; B320.a.44.i ; B.321.a.44.i; B.322.a.44.i; B.323.a.44.i; B.324.a.44.i; B.325.a.44.i ; B.326.a.44.i; B3 27.a.44.i; B.328.a.44.i; B.329.a.44.i; B.330.a.44.i; B.331.a.44.i; B. 332.a * 44.i; B.333.a.44.i; B.334.a.44.i; B.335.a.44.i; B.336.a.44.i; B. 337.a.44.i; B.338.a.44.i; B.339.a.44.i; B.340.a.44.i; B.341.a.44.i; B. 342.a.44.i; B.343.a.44.i; B.344.a.44.i; B.345.a.44.i; B.346.a.44.i; B. 347.a.44.i; B.348.a.44.i; B.349.a.44.i; B.350.a.44.i; B.351.a.44.i; B. 352.a.44.i; B.353.a.44.i; B.354.a.44.i; B.355.a.44.i; B.356.a.44.i; B. 357.a.44.i; B.358.a.44.i; E.2.a.44.i; E.3.a.44.i; E.4.a.44.i; E. 5.a.44.i; E.9.a.44.i; E.100.a.44.i; E.101.a.44.i; E.102.a.44.i; E. 103.a.44.i; E.104.a.44.i; E.105.a.44.i; E.106.a.44.i; E.107.a.44.i; E. 108.a.44.i; E.109.a.44.i; E.110.a.44.i; E.lll.a.44.i; E.112.a.44.i; E. 113.a.44.i; E.H4.a.44.i; E.115.a.44.i; E.116.a.44.i; E.117.a.44.i; E. 118.a.44.i; £ .119-3.44,1; E.120.a.44.i; E.121.a.44.i; E.122.a.44.i; E.123. a.44.i; E.124.a.44.i; E.125.a.44.i; H.126.a.44.i; E.127.a.44.i; E.128. a.44.i; E.129.a.44.i; E.130.a.44.i; E.131.a.44.i; E.132.a.44.i; E.133. a.44.i; E.134.a.44.i; E.1 35.a.44.i; E.136.a.44.i; E.137.a.44.i; E.138.a.44.i; E.139.a.44.i; E. 140.a.44.i; E.141.a.44.i; E.142.a.44.i; E.143.a.44.i; E.144.a.44.i; E. 145.a.44.i; E.146.a.44.i; E.147.a.44.i; E.148.a.44.i; E.149.a.44.i; E. 150.a.44.i; E.151.a.44.i; E.152.a.44.i; E.153.a.44.i; E.154.a.44.i; E. 155.a.44.i; E.156.a.44.i; E.157.a.44.i; E.158.a.44.i; E.159.a.44.i; E. 160.a.44.i; E.161.a.44.i; E.162.a.44.i; E.163.a, 44.i; E.164.a.44.i; E. 165.a.44.i; E.166.a.44.i; E.167.a.44.i; E.168.a.44.i; H.169.a.44.i; E. 170.a.44.i; H.171.a.44.i; E.172.a.44.i; E.173.a.44.i; E.174.a.44.i; E. 175.a.44.i; E.176.a.44.i; E.177.a.44.i; E.178.a.44.i; E.179.a.44.i; E. 180.a.44.i; E.181.a.44.i; E.182.a.44.i; E.183.a.44.i; E.184.a.44.i; E. 185.a.44.i; E.186.a.44.i; E.187.a.44.i; H.188.a.44.i; E.189.a.44.i; E. 190.a.44.i; E.191.a.44.i; E.192.a.44.i; E.193.a.44.i; E.194.a.44.i; E. 195.a.44.i; H.196.a.44.i; E.197.a.44.i; E.198.a.44.i; E.199.a.44.i; E. 200.a.44.i; E.201.a.44.i; E.202.a.44.i; E.203.a.44.i; E.204.a.44.i; E. 205.a.44.i; E.206 .a.44.i; E.207.a.44.i; E.208.a.44-i; E.209.a.44.i; E.210.a.44.i; E.211 .a.44.i; E.212.a.44.i; E.213.a.44.i; E.214.a.44.i; E.215.a.44.i; E.216 .a.44.i; E-217.a.44.i; E.218.a.44.i; E.219.a.44.i; E.220.a.44.i; E.221 .a.44.i; E.222.a.44.i; E.223.a.44.i; E.224.a.44.i; E.225.a.44.i; E.226 .a.44.i; E.227.a.44.i; E.228.a.44.i; E.229.a.44.i; E.230.a.44.i; E.231 .a.44.i; E.232.a.44.i; E.233.a.44.i; E.234.a.44.i; E.235.a.44.i; E.236 .a.44.i; E.237.a.44.i; H.238.a.44.i; H.239.a.44.i; E.240.a.44.i; H.241 .a.44.i; E.242.a.44.i; E.243.a.44.i; E.244.a.44.i; E.245.a.44.i; E.246 .a.44.i; E.247.a.44.i; E.248.a.44.i; E.249.a.44.i; E.250.a.44-i; E.251 .a.44.i; E'.252.a.44.i; E.253.a.44.i; E.254.a.44.i; E.255.a.44.i; E. 256.a.44.i; E.257.a.44.i; E.258.a.44.i; E.259.a.44.i; E.260.a.44.i; E. 261.a.44.i; H.262.a.44.i; E.263.a.44.i; E.264.a.44.i; E.265.a.44.i; H. 266.a.44.i; E.267.a.44.i; E.268.a.44.i; E.269.a.44.i; E.270.a.44.i; E. 271.a.44.i; This paper is applicable to the standard of the trapped valve family (CNS) Λ4 Grid (2 Yi Gongqing) 182- ^ -a-ife-^^ C- The Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs of the People's Republic of China 4 266 6 3 Λ a? Β7 V. Description of the invention (18 °) E.272.a.44.i; E.273. a.44.i; E.274.a.44.i; E.275.a.44.i; E.276.a.44.i; E.277.a.44.i; H.278. a.44.i; E.279.a.44.i; H.2S0.a.44.i; E.2Sl.a.44.i; E.2S2.a.44.i; E.283. a.44.i; E.2S4.a.44.i; E.2S5.a.44.i; E.286.a.44.i; E.287.a.44.i; E.288. a.44.i; E.289.a.44.i; E.290.a.44.i; E.291.a.44.i; E.292.a.44.i; E.293. a.44.i; E.294.a.44.i; E.295.a.44.i; E.296.a.44.i; E.297.a.44.i; E.298. a.44.i; E.299.a.44.i; E.300.a.44.i; E.301.a.44.i; E.302.a.44.i; E.303. a.44.i; E.304.a.44.i; E.305.a.44.i; E.306.a.44.i; E.307.a.44.i; H.3〇 8.a.44.i; E.309.a.44.i; E.310.a.44.i; H.311.a.44.i; E.312.a.44.i; E. 313.a.44.i; E.314.a.44.i; E.315.a.44.i; E.316.a.44.i; E.317.a.44.i; E. 318.a.44.i; E.319.a.44.i; E.320.a.44.i; E.321.a.44.i; E.322.a.44.i; E. 323.a.44.i; E.324.a.44.i; E.325.a.44.i; E.326.a.44.i; E.327.a.44.i; E. 328.a.44.i; E.329.a.44.i; E.330.a.44.i; E.331.a.44.i; E.332.a.44.i; E. 333.a.44.i; E.334.a.44.i ; E.335.a.44.i; E.336.a.44.i; E.337.a.44.i; E.338.a.44.i; E339.a.44.i; E .34〇.a.44.i; E.341.a.44.i; E.342.a.44.i; E.343.a.44.i; E.344.a.44.i; E.345.a.44.i; E.346.a.44.i; E.347.a.44.i; E.348.a.44.i; E.349.a.44.i; E.350.a.44.i; E.351.a.44.i; E.352.a.44.i; E.353.a.44.i; E.354.a.44.i; E.355.a.44.i; E.356.a.44.i; E.357.a.44.i; E.358.a.44.i; B.2.a.4.i; B.3.a.4.i; B.4.a.4.i; B.5.a.4.i; B.9.a.4.i; B.100.a.4.i; B.101.a.4.i; B.102.a.4.i; B.103.a.4.i; B.104.a.4.i; B.105.a.4.i; B.106.a.4.i; B.107.a.4.i; B.108.a.4.i; B.109.a.4.i; B.ll〇.a.4.i ; Bma4.i; B.112.a.4.i; B.113.a.4.i; B.114.a.4.i; B.115.a.4.i; B.116. a.4.i; B.117.a.4.i; B.118.ai.i; B.119.a.4.i; B.120.a.4.i; B.121.a. 4.i; B.122.a.4.i; B.123.a.4.i; B.124.a.4.i; B.125.a.4.i; B.126.a. 4.i; B.127.a.4.i; B.128.a.4.i; B.129.a.4.i; B.130.a.4.i; B.131.a. 4.i; B.132.a.4.i; B.133.a.4.i; B.134.a.4.i; B.l35.a.4.i; B.136.a. 4.i; B.137.a.4.i; B.138.a.4.i; B.139.a.4.i; B.140.a.4.i; B.141.a. 4.i; B.142.a.4.i; B.143.a.4.i; B.144.a.4.i; B.145.a.4.i; B.146.a. 4 , i; B.147.a.4.i; B.148.a.4.i; B.149.a.4.i; B.150.a.4.i; B.151.a.4 .i; B.152.a.4.i; B.153.a.4.i; B.154.a.4.i; B.155.a.4.i; B.156.a.4 .i; B.157.a.4.i; B.158.a.4.i; B.159.a.4.i; B.160.a.4.i; B.161.a.4 .i; B.162.a.4.i; B.163.a.4.i; B.164.a.4.i; B.165.a.4.i; B.166.a.4 .i; B.167.a.4.i; B.168.a.4.i; B.169.a.4.i; B.170.a.4.i; B.171.a.4 .i; B.172.a.4.i; B.173.a.4.i; B.174.a.4.i; B.175.a.4.i; B.176.a.4 .i; B.177.a.4.i; B.178.a.4.i; B.179.a.4.i; B.180.a.4.i; B.181.a.4 .i; B.182.a.4.i; B.183.a.4.i; B.184.a.4.i; B.185.a.4.i; B.186.a.4 .i; B.187.a.4.i; B.188.a.4.i; B.189.a.4.i; B.190.a.4.i; B.191.a.4 .i; B.192.a.4.i; B.193.a.4.i; B.194.a.4.i; B.195.a.4.i; B.196.a.4 .i; B.197.a.4.i; B.198.a.4.i; B.199.a.4.i; B.200.a.4.i; B.201.a.4 .i; B.202.a.4.i; B.203.a.4.i; B.204.a.4.i; B.205.a.4.i; B.206.a.4 .i; B.207.a.4.i; B.208.a.4.i; B.209.a.4.i; B.210.a.4.i; B.211.a.4 .i; B.212.a.4.i; B.213.a.4.i; B.214.a.4.i; B.215.a.4.i; B.216.a.4 .i; B.217.a.4.i; B.2l8.a.4.i; B.219, a.4.i; B.220.a.4.i; B.221.a.4 .i; B.222.a.4.i; B.22 3.a.4.i; B.224.a.4.i; B.225.a.4.i; B.226.a.4.i; B.227.a.4.i; B. 228.a.4.i; B.229.a.4.i; B.230.a.4.i; B.231.a.4.i; B.232.a.4.i; B. 233.a.4.i; B.234.a.4.i; B.235.a.4.i; B.236.a.4.i; B.237.a.4.i; B. 23S.a.4.i; B.239.a.4.i; B.240.a.4.i; B.241.a.4.i; B.242.a.4.i; B. 243.a.4.i; B.244.a.4.i; B.245.a.4.i; B.246.a.4.i; B.247.a.4.i; B. 248.a.4.i; B.249.a.4.i; B.250, a.4.i; B.251.a.4.i; B.252.a.4.i; B. 253.a.4.i; B.254.a.4.i; B.255.a.4.i; B.256.a.4.i; B.257.a.4.i; B. 258.a.4-i; B.259.a.4.i; B.260.a.4.i; B.261.a.4.i; B.262.a.4.i; B. 263.a.4.i; B.264.a.4.i; B, 265.a.4.i; B.266.a.4.i; B.267.a.4.i; B. 268.a.4.i; B.269, a.4.i; B.270.a.4.i; B.271.a.4.i; B.272.a.4.i; B. 273.a.4.i; B.274.a.4.i; B.275.a.4.i; B.276.a.4.i; B.277.a.4.i; B. 278.a.4.i; B.279.a.4.i; B.2S0.a.4.i; B.2Sl.a.4.i; B.282.a.4.i; B. 2S3.a.4.i; B.284.a.4.i; B.2S5.a.4.i; B.286.a.4, i; B.2S7.a.4.i; B. 2S8.a.4.i; B.289.a.4.i; B.290.a.4.i; B.291.a.4.i; B.292.a.4.i; B. 293.a.4.i; B.294.a.4.i; B.295.a.4.i; B.296.a.4.i; B.297.a.4.i; B. 298.a.4.i; B.299.a.4.i; B.300.a.4.i; B.301.a.4.i; B.302.a.4.i; B.303.a.4.i; B.304.a.4.i; B.305.a.4.i; B.306.a.4.i; B.307.a.4.i; B.30S.a.4.i; B.309.a.4.i; B.310.a.4.i; B.311.a.4.i; B.312.a.4.i; B.313.a.4.i; B.314.a.4.i; B.315.a.4.i; B.316.a.4.i; B.3l7.a, 4.i; B.318.a.4.i; B.319.a.4.i; B.320, a.4.i; B.321.a.4.i; B.322, a.4.i; B.323.a.4.i; B.324.a.4.i; B.325.a.4.i; B.326.a.4.i; B.327.a.4.i; B.32S.a.4.i; B.329.a.4.i; B.330.a.4.i; This paper size is applicable to Chinese National Standard (CNS) Λ4 present grid (2U) X 297 public epidemic) -183-

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Q 4 B.134.a.ll-i; B.135.a.ll.i; B.136.a.ll.i; B.137.a.ll.i; B.138.a.ll. i; B.139.aJl.i; B.14〇.a.ll.i; Bl-il.a.ll.i; B.142.a.ll.i; B.143.a.ll.i ; B.144.a.ll.i; B.145.a.ll.i; B.146.a, ll.i; B.147.a.ll.i; B.148.a.ll.i ; B.149.a.ll.i; B.150.a.ll.i; B.151.a.ll.i; B.152.a.ll.i; B.153.a.ll.i ; B.154.a.ll.i; B.155.a.ll.i; B.l56.a.ll.i; B, 157.a.ll.i; B.158.a.ll-i ; B.159.a.ll.i; B.160.a.ll.i; B.161.a.ll.i; B.162.a.ll.i; B.163.a.ll.i ; B.164.a.ll.i; B.165.ani; B.166.a.ll.i; B.167.a.ll.i; B.168.a.ll'i; B'169 .a.ll.i; B.170.a.lLi; B.171.a.ll.i; B, 172.a.ll.i; B.173.a.ll.i; B.174.a .ll.i; B.175.a.ll.i; B, 176.a.ll.i; B.177.a.ll.i; B.178.a.ll.i; B.179.a .ll.i; B.lSO.a.ll.i; B.181.a.ll.i; B.182.a.ll.i; B.l83.a.ll.i; B.184.a .ll.i; B.185.a.ll.i; B.186.a.ll.i; B.187.a.ll.i; B.188.a.ll.i; B.189.a .ll.i; B.190.a.ll.i; B.191.a.ll.i; B.192.a.ll.i; B.193.a.ll.i; B.194.a .ll.i; B.195.a.ll.i; B.196.a.ll.i; B.197.a.ll.i; B.198.a.ll.i; B.199.a .ll.i; B.200.a.ll.i; B.201.a.ll.i; B.202.a.ll.i; B, 203.a.ll.i; B.204.a.ll.i; B.205.a.ll.i; B.206, a.ll.i; B.207.aHi; B.208. a.ll.i; B.209.a.ll.i; B.210.a.ll.i; B.211.a.ll.i; B.213.a.ll.i; B.214, a.lli; B.215.a.ll.i; B.216.a.ll.i; B.217.a.ll.i; B.218.a.ll.i; B.219.a. ll.i; B.220.a.ll.i; B.221.a.ll.i; B.222.a.ll.i; B.223.a.ll.i; B.224.a. ll.i; B.225.aUi; B.226.a.ll.i; B, 227.a.ll.i; B.228.a.ll.i; B.229.a.ll, i; B.230.a.ll.i; B.231.a.lla; B.232.a.ll.i; B.233.a.ll.i; B.234.a.ll.i; B. 235.a.ll.i; B.236.a.ll.i; B.237.a.ll.i; B.238.a.ll.i; B.239.a.ll.i; B. 240.a.ll.i; B.241.a.ll.i; B.242.a.ll.i; B.243.a.ll.i; B.244.a.ll.i; B. 245.a.ll.i; B.246.a.ll.i; B.247.a.ll.i; B.248.a.ll.i; B.249.a.ll-i; B. 25〇.a.ll-i; B.251.a.ll.i; B.252.a.ll.i; B.253.a.ll.i; B.254.a.ll.i; B .255.a.ll.i; B.256.a, ll.i; B.257.a.ll.i; B.258.a.ll.i; B.259.a.ll.i; B .260.a.ll.i; B.261.a.ll.i; B.262.a.ll.i; B.263.a.ll.i; B.264.a.ll.i; B .265.a.ll.i; B.266.a.ll.i; B.267.a.ll.i; B.268.a.lli; B.269.a.ll.i; B.270 .a.ll.i; B.271.a.ll.i; B.272.a.ll.i; B.273.a.ll.i; B.274.a.ll.i; B.275 . a.ll.i; B.276.a.ll.i; B.277.a.ll.i; B.278.a.ll.i; B.279.a.ll.i; B.280. a.ll.i; B.281.a.ll.i; B.282.a.ll.i; B.283.a.ll.i; B.284.aUi; B.285.a.ll. i; B.286.a.ll.i; B.287.a.ll.i; B.288.a.ll.i; B.289.a.ll.i; B.290.a.ll. i; B.291.a.ll.i; B.292.a.ll.i; B.293.a.ll.i; B.294.a.ll.i; B.295.a.ll. i; B.296.a.ll.i; B.297.a.ll.i; B.298.a.ll.i; B.299.a.ll.i; B.SOO.a.ll. i; B.301.a.ll.i; B.302.a.ll.i; B.303.a.lX.i; B.304.a.ll.i; B.305.a.ll. i; B.306.a.ll.i; B.307.a.ll.i; B.308.a.ll.i; B.309.a.ll.i; B.310.a.ll. i; B.311.a.ll.i; B.312.a.ll.i; B.313.a.ll.i; B.314.a.ll.i; B.315.a.ll. i; B.316.a.ll.i; B.317.a.ll.i; B.318.a.ll.i; B.319.a.ll.i; B.320.a.ll. i; B.321.a.ll.i; B.322.a.ll.i; B.323.a.ll.i; B.324.a.ll.i; B.325.a.ll. i; B.326.a.ll.i; B.327.aUi; B.328.a.ll.i; B.329.a.ll.i; B.330.a.llri; B.331. a.ll.i; B.332.a.ll.i; B.333.a.ll.i; B.334.a.ll.i; B.335.a.ll.i; B.336. a.ll.i; B.337.a.ll.i; B.338.a.ll.i; B.339.a.ll.i; B.340.a.ll.i; B.341. a.ll.i; B.342.a.ll.i; B.343.a.ll.i; B.344.a.ll.i; B.345.a.ll.i; B.346. a.ll.i ; B.347.a.ll.i; B.348.a.ll.i; B.349.a.ll.i; B.350.a.ll.i; B.351.a.ll.i ; B.352.a.ll.i; B.353.a.ll.i; B.354.a.ll.i; B.355.a.ll.i; B.356.a.ll.i ; B.357.all.i; B.358.a.ll.i; E.2.a.ll.i; E.3.a.ll.i; E.4.a.ll.i; E .5.a.ll.i; E.9.a.ll.i; H.lOO.a.ll.i; E.lOl.a.ll.i; E.102.a.ll.i; E .103.a.ll.i; E.104.a.ll.i; E.105.a.ll.i; E.106.a.ll.i; E.107.a.ll; i; E .lOS.a.ll.i; E.109.a.ll.i; E.llO.a.ll.i; E.112.a.ll.i; E.113.a.ll.i; E .114.a.ll.i; E.llS.a.ll.i; E.116.a.ll.i; E.117.a.ll.i; E.118.a.ll.i; E .119.a.ll.i; E.lZl.a.ll.i; E.122.a.ll.i; E.123.a.ll.i; E.124.a.ll.i; E .125.a.ll.i; E.126.a.ll.i; E.127.a.ll.i; E.12S.a.ll.i; E.129.a.ll.i; E .130.a.ll.i; E.132.a.ll.i; E.133.a.ll.i; E.134.a.ll.i; E.135.a.ll.i; E .136.ani; H.137.a.ll.i; E.13S.a.ll.i; E: 139.a.ll.i; E.HO.a.ll.i; E.141.a .ll.i; E.142.a.ll.i; E.143.a.ll.i; E.144.a.ll.i; E.H5.a.ll.i; E.146.a .ll.i; E.147.a.ll.i; E.149.aUi; E.lSO.a.lli; E.151.a.ll.i; E.152.a.ll.i; E .153.a.ll.i; E.154.a.ll.i; E.155.a.ll.i; E.156.aUi, E.157.a.ll.i; E.158.a .ll .i; This paper size applies to China National Standard (CNS) Λ4 specification (210X297 Gongcheng) _ Mg _

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Description of the invention (13 E.159.a.ll.i; E.16〇.a.ll.i; E.161.a.ll.i; E.162. aUi; E.163.a.ll.i; H.164.a.ll.i; .E.165.aUi; E.166.a.ll, i; E.167.a.ll.i; E .168.a, ll.i; E.169.aUi; E.170.a.11.i; E.171.a.ll.i; E.172.a.ll.i; E.173.a .ll.i; E.174.a.ll.i; E.175.a.ll.i; E.176.a.ll.i; E.177.a.ll.i; E.178.a .ll.i; E.179.a.ll.i; E.lSO.a.ll.i; E.181.a.ll.i; E.182.a.ll.i; 5 E.183. a.11.i; E.184.a.ll.i; E.185.a.ll.i; E.186.a.ll.i; E.187.a.ll.i; E.188. a.ll.i; E.189.a.lU · E.190.a.ll.i; E.191.a.ll.i; E.192.a.ll.i; E.193.a. ll.i; E.194.a.ll.i; E.195.a.ll.i; E.196.a.ll.i; E.197.a.ll.i; E.198.a. ll.i; E.199.a.ll.i; E.200.a.ll.i; E.201.a.ll.i; E.202.a.ll.i; E.203.a. ll.i; E.204.a.ll.i; E.205.a.ll.i; E.206.a.ll.i; E.207.a.ll.i; E.208.a. ll.i; E.209.a.Xl.i; E.210.a.ll.i; E.211.a.ll.i; E.212.a.ll.i; 10 E.213.a .ll.i; E214.a.ll.i; E.215.a.ll.i; E.216.a.ll.i; E.217.a.lU; E.218.a.ll.i ; E.219.a.ll.i; E.22〇.a.ll.i; E.221.a.ll.i; E.222.a.ll.i; E.223.a.ll. i; E.224.a.ll.i; E.225.a.ll.i; E.226.a.ll. i; E.227.a * ll.i; E.228.a.ll.i; E.229.a.ll.i; E.230.aUi; E.231.a.ll.i; E. 232.a.ll.i; E.233.a.ll.i; E.234.a.ll.i; E.235.a.Xl.i; E.236.a.ll.i; E. 237.a.ll.i; E.238.a.ll.i; E.239.a.ll.i; E.240.a.ll.i; E.241.a.ll.i; E. 242.a.ll.i; 15 E.243.a.ll.i; E.244.a.ll.i; E.245.a.ll.i; E.246.a.ll.i; E .247.a.ll.i; E.248.a.ll.i; E.249.a.ll.i; E.250.a.ll.i; E.251.a.ll.i; E .252.a.ll.i; E.253.a.ll.i; E.254.a.ll.i; E.255.a.ll.i; H.256.a.ll.i; E .257.a.ll.i; E.258.a.ll.i; E.259.a.ll.i; E.260.a.ll.i; E.261.a.ll.i; E .262.a.ll.i; E.263.a.ll.i; E.264.a.ll.i; E.265.a.ll.i; E.266.a.ll.i; E .267.a.ll.i; E.268.a.ll.i; E.269.a.ll.i; E.270.a.ll.i; E.27La.ll.i; E.272 .a.ll.i; ZO E.273.a.ll.i; E.274.a.ll.i; E.275.a.ll.i; E.276.aUi; E.277.a. ll.i; E.278.a.ll.i; E.279.a.lU; E.280.a.ll.i; E.2Sl.a.ll.i; E.282.a.ll. i; E.283.a.ll.i; E.284.a.ll.i; E.285.a.ll.i; E.286.a.ll.i; E.287.a.ll. i; H.288.a.ll.i; E.289.a.ll.i; E.290.a.ll.i; E.291.a.ll.i; E.292.a.ll. i; E.293.a.ll.i; E.294.a.ll.i; E.295.a.lli; E.Z96.a.ll.i; E.297 .a.ll.i; E.298.a.ll.i; E.299.a.ll.i; E.30Q.a.ll.i; E.301.a.ll.i; E.302 .a.ll.i; 15 E.303.a.ll.i; E.304.a.ll.i; E305.a.ll.i; E.306.a.ll.i; E.307. a.ll.i; E.308.a.ll.i; E.309.a.Xl.i; E.310.a.ll.i; E.311.a.ll.i; H.312. a.ll.i; E.313.a.ll.i; E.314.a.ll.i; E.315.a.lH; E.316.a.ll.i; E.317.a. ll.i; E.318.ani; E.319.a.ll.i; E.320.a.ll.i; E.321.a.ll.i; E.322.a.ll.i; E.323.a.ll.i; E.324.a.ll.i; E.325.a.ll.i; H.326.a.ll.i; E.327.a.ll.i; E.328.a.ll.i; E.329.a.ll.i; E.330.a.ll.i; E.331.a.ll.i; E.332.a.ll.i; ! 0 E.333.a.ll.i; E.334.a.ll.i; E.335.a.ll.i; E.336.a.ll.i; E.337.a.ll. i; E.338.a.ll.i; H.339.a.ll.i; E.340.a.ll.i; E.341.a.ll.i; E.342.a.ll. i; E.343.a.ll.i; E.344.a.ll.i; E.345.a.ll.i; E.346.a.ll.i; E.347.a.ll. i; E.348.a.ll.i; E.349.a.ll.i; E.350.a.ll.i; E.351.a.ll.i; E.352.a.ll. i; E.353.a.ll.i; E354.a.ll.i; E.355.a.ll.i; E.356.a.ll.i; E.357.a.ll.i; E.358.a.ll.i; A.661.aAi; A.662.a.4.i; A.663.a.4.i; A.664.a.4.i; 5 A.665 .a.4.i; B.661.a.4.i; B.662.a.4.i; B.663.a.4.i; B.664.a.4.i; B.665 .a.4.i; C. 661.a.4.i; C.662.a.4.i; C.663.a.4.i; C.664.a.4.i; C.665.a.4.i; A. 661, a.ll.i; A.662.a.ll.i; Printed by the Shellfish Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs A. 663.a.ll.i; A.664.a.ll.i; A .665.a.ll.i; B.661.a.ll.i; B.662.a.ll.i; B.663.a.ll.i; B. 664.a.ll.i; B .665.a.ll.i; C.661.a.ll.i; C.662.a.ll.i; C.663.a.ll.i; C.664.a.ll.i; C .665.a.ll.i; A.661.a.44.i; A.662.a.44, i; A.663.a.44.i; A.664.a.44.i; A. .665.a.44.i; 0 B.661.a.44.i; B.662.a.44.i; B.663.a.44.i; B.664.a.44.i; B.665.a.44.i; C.661.a.44.i; C.662.a.44.i; C.663.a.44.i; C.664.a.44.i; C.665.a.44.i; A.666.a.4.i; A.666.a.ll.i; A.666.a.44.i; A.666.b.4.i; A.666.b.ll.i; A.666.b.44.i; A.666.x.4.i; A.666.x.ll.i; Α.666.χ.44.Ϊ; A.666.y.4.i; A.666.y.ll.i; A.666.y.44.i; A.666.z.4.i; A.666.z.ll.i; A.666.z.44.i; Α.666.Α.4.Ϊ; Α.666.Α.Π.Ϊ; A.666.A.44.i; A.666.B.4.i; A.666.B.ll.i; 5 Α.666.Β.44.Ϊ; A.666.C.4.i; A.666.C.ll.i; A.666.C.44.i ; A.666.D.4.i; A.666.D.ll.i; A.666.D.44.i; Α.666.E.4.Ϊ; A.666.E.ll.i ; A.666.E.44.i; A.666.F.4.i; A.666.F.ll.i; A. 6 66.F.44.i; B.666.a.4.i; B.666.a.ll.i; B.666.a.44.i; B.666.b.4.i; B. 666.b.ll.i; B. 666.b.44.i; B.666.x.4.i; B.666.xUi; Β.666.χ.44.Ϊ; B.66〇.y .4.i; B.666.y.ll.i; National standard for towels f4 for this paper (CNSM4 specification (210X297 mm) _ 6 A7 B7 Λ266 6 3 V. Description of the invention (184) B.666 .y.44.i; B.666.z.4.i; B.666.z.ll.i; B.666.2.44.i; Β.666.Β.4.Ϊ; Β.666.Β .11.Ϊ; Β.666.Β.44.Ϊ; Β.666.Β.4.Ϊ; B: 666.B.ll.i; B.666.B.44.i; B.666.C .4.i; B.666.C.ll.i; B.666.C.44.i; B.666.D.4.i; B.666.D.ll.i; B.666.D .44.i; B.666.E.4.i; B.666.E.ll.i; B.666.E, 44.i; B.666.F.4.i; B.666.F .II.1; B.666.F.44.i; E.666.a.4.i; E.666.a.11.i; 5 E.666.a.44.i; E.666. b.4.i; E.666.b.ll.i; E.666.b.44.i; E.666.x.4.i; E.666.x.ll.i; E.666. x.44.i; E.666.y.4.i; E.666.y.ll.i; E.666.y.44.i; E.666.z.4.i; E.666. z.ll.i; Ε.666.Z.44.Ϊ; Ε.666.Ε.4.Ϊ; E.666.E.ll.i; Ε.666.Ε.44.Ϊ; Ε.666. Β.4.Ϊ; Ε.666.Β.11.Ϊ; Ε.666.Β.44.Ϊ; E.666.C.4.i; E.666.C.1U; E.666.C. 44.i; E.666.D.4.i; E.666.D.1U; E.666.D, 44, i; Ε.6 66.Ε.4.Ϊ; Ε.666.Ε.11.Ϊ; Ε.666.Ε.44.Ϊ; E.666.F.4.i; E.666.F.ll.i; 10 H .666.F.44.i; A.2.a.46.i; A.3.a.46.i; A.4.a.46.i; A.5.a.46.i; A .7.a.46.i; A.9.a.46.i; A.100.a.46.i; A.101.a.46.i; A.102.a.46.i; A .103.a.46.i; A.104.a.46.i; A.105.a.46.i; A.106.a.46.i; A.107.a.46.i; A. .108.a.46.i; A.109.a.46.i; A.110.a.46.i; A.lll.a.46.i; A.112.a.46.i; A. .113.a.46.i; A.114.a.46.i; A.115.a.46.i; A.116.a.46.i; A.117.a.46.i; A. .118.a.46.i; 15 A.119.a.46.i; A.120.a.46.i; A.121.a.46.i; A.122.a.46.i; A.123.a.46.i; A.124.a.46.i; A.125.a.46.i; A.126.a.46.i; A.127.a.46.i; A.128.a.46.i; A.129.a.46.i; A.130.a.46.i; A.131.a.46.i; A.132.a.46.i; A.133.a.46.i; A.134.a.46.i; A.135.a.46.i; A.136.a.46.i; A.137.a.46.i; A.138.a.46.i; A.139.a.46.i; A.140.a.46.i; A.141.a.46.i; A.2.a.47.i; A.3.a.47.i; A.4.a.47.i; A.5.a.47.i; A.7.a.47.i; A.9.a.47.i; A.100.a.47.i; A.101.a.47.i; 20 A.102.a.47.i; A.103.a.47.i; A.104.a.47.i ; A.105.a.47.i; A.106.a.47.i; A.107.a.47.i; A.108.a.47.i; A.109.a.47.i ; A.110.a.47.i; A.lll.a.47.i; A. 112.a.47.i; A.113.a.47.i; A.114.a.47.i; A.115.a.47.i; A.116.a.47.i; A. 117.a.47.i; A.118.a.47.i; A.119.a.47.i; A.120.a.47.i; A.121.a.47.i; A. 122.a.47.i; A.123.a.47.i; A.124.a.47.i; A.125.a.47.i; A.126.a.47.i; A. 127.a.47.i; A.128.a.47.i; A.129.a.47.i; A.130.a.47i; A.131.a.47.i; A.132. a.47.i; A.133.a.47.i; A.134.a.47.i; A.135.a.47.i; A.136.a.47.i; A.137. a.47.i; A.138.a.47.i; A.139.a.47.i; A.140.a.47.i; A.141.a.47.i; A.2. a.48.i; A.3.a.48.i; A.4.a.48.i; A.5.a.48.i; A.7.a.48.i; A.9. a.48.i; A.100.a.48.i; A.101.a.48.i; A.102.a.48.i; A.103.a.48.i; A.104. a.48.i; A.105.a.48.i; A.106.a.48.i; A.107.a.48.i; A.108.a.48.i; A.109. a.48.i; A.110.a.48.i; A.lll.a.48.i; A.112.a.48.i; A.113.a.48.i; A.114. a.48.i; 50 A.115.a, 48.i; A-116-a.48.i; A.117.a.48.i; A.118.a.48.i; A.119 .a.48.i; A.120.a.48.i; A.121.a.48.i; A, 122.a.48.i; A.123.a.4S.i; A.124 .a.48.i; A.125.a.48.i; A.126.a.48.i; A.127.a.48.i; A.128.a.48.i; A.129 .a.48.i; A.130.a.48.i; A.131.a.48.i; A.132.a.48.i; A.133.a.48.i; A.134 .a.48.i; A.135.a.4S.i; A. 136.a.48.i; A.137.a.48.i; A.138.a.48.i; A.139.a.48.i; A.140.a.48.i; A. 141.a.48.i; A.2.a.49.i; A.3.a.49.i; A.4.a.49.i; A.5.a.49.i; 15 A .7.a.49.i; A.9.a, 49.i; A.100.a.49.i; A.101.a.49.i; A.102.a.49.i; A. .103.a.49.i; A.104.a.49.i; A.105.a.49.i; A.106.a.49.i; A.107.a.49.i; A. .108.a.49.i; A.109.a.49.i; A.110.a.49.i; A.lll.a.49.i; A.112.a.49.i; A. .113.a.49.i; A.114.a.49.i; A.115.a.49.i; A.116.a.49.i; A.117.a.49.i; A. .118.a.49.i; A.119.a.49.i; A.120.a.49.i; A.121.a.49.i; A.122.a.49.i; A. .123.a.49.i; A.124.a.49.i; A.125.a.49.i; A.126.a.49.i; A.127.a.49.i;: 0 A.128.a.49.i; A.129.a.49.i; A.130.a.49.i; A.131.a.49.i; A.132.a.49.i ; A.133.a.49.i; A.134.a.49.i; A.135.a.49.i; A.136.a.49.i; A.137.a.49.i ; A.138.a.49.i; A.139.a.49.i; A.140.a.49.i; A.141.a.49.i; A.2.a.50.i ; A.3.a.50.i; A.4.a.50.i; A.5.a.50.i; A.7.a.50.i; A.9.a.50.i ; A.IOO.a.SO.i; A.IOl.a.oO.i; A, 102.a.50.i; A.103.a.50.i; A.104.a.50.i ; A.105.a.50.i; A.106.a.50.i; A.107.a.50.i; A.10S.a.50.i; A.109.a.50.i ; A.llO.a.SO.i; 5 A.lll.a.50.i; A.112. a.50.i; A.113.a.50.i; A.114.a.50.i; A.115.a.50.i; A.116.a.50.i; A.117. a.50.i; A.118.a.50.i; A.119.a.50.i; A.120.a.50.i; A.121.a.50.i; A.122. a.50.i; A.123.a.50.i; A.124.a.50.i; A.125.a.50.i; A.120.a.50.i; A.127. a.50.i; A.128.a.50.i; A.129.a.50.i; A.130.a.50.i; A.131.a.5〇.i; A.132 .a.50.i; A.133.a.50.i; A.134.a.50.i; The paper size is universal for each country: ¾ family standard (CN'S) as specified (210X297) I (please read the note on the back before writing 4 'on this page) • Equipment ·,? Τ Printed by the Consumer Cooperatives of the Central Bureau of Standards of the Ministry of Economy 426663 Printed by A.135.a.50.i; A.136.a.50.i; A.137.a.50.i; A.138.a.50.i ; A.139.a.50.i; A.140.a.50.i; A.141.a.50.i; A.2.a.51.i; A.3.a.51.i ; A.4.a.51.i; A.5.a.51.i; A.7.a, 51.i; A.9.a.51.i; A.100.a.51.i ; A.101.a.51.i; A.202.a.51.i; A.103.a.51.i; A.104.a.51.i; A.105.a.51.i ; A.106.a.51.i; A.107.a, 51.i; A.108.a.51, i; A.109.a.51.i; A.110.a.51.i ; A.lll.a.51.i; A.112.a.51.i; A.113.a.51.i; A.114.a.51.i ; A.115.a.51.i; A.116.a.51.i; A.117.a.51.i; A.118.a.51.i; A.119.a.51.i ; A.120.a.51.i; A.121.a.51.i; A.122.a.51.i; A.123.a.51.i; A.124.a.51.i ; A.125.a.51.i; A.126.a.51.i; A.127.a.51.i; A.12S.a.51.i; A.129.a.51.i ; A.130.a.51.i; A.131.a.51.i; A.132.a.51.i; A.133.a.51.i; A.134.a.51.i ; A.135.a.51.i; A.136.a.51.i; A.137.a.51.i; A.138.a.51.i; A.139.a.51.i ; A.140.a.51.i; A.141.a.51, i; A.2.b.46.i; A.3.b.46.i; A.4.b.46.i ; A.5.b.46.i; A.7.b.46.i; A.9.b.46.i; A.100.b.46.i; A.101.b.46.i ; A.102.b.46.i; A.103.b.46.i; A.104.b.46.i; A.105.b.46.i; A.106.b.46.i ; A.107.b.46.i; A.108.b.46.i; A.109.b.46.i; A.110.b.46.i; A.lll.b.46.i ; A.112.b.46.i; A.113.b.46.i; A.114.b.46.i; A.115.b.46.i; A.116.b.46.i ; A.117.b.46.i; A.U8.b.46.i; A.ll9.b.46.i; A.120.b.46.i; A.121.b.46.i ; A.122.b.46.i; A.123.b.46.i; A.124.b.46.i; A.125.b.46.i; A.126.b.46.i ; A.127.b.46.i; A.128.b.46.i; A.129.b.46.i; A.130.b.46.i; A.131.b.46.i ; A.132.b.46.i; A, 133.b.46.i; A.134.b.46.i; A.135.b.46.i; A.136.b.46.i ; A.137.b.46.i; A.138.b.46.i; A.1 39.b.46.i; A.14〇.b.46.i; A.141.b.46.i; A.2.b.47.i; A.3.b.47.i; A .4.b.47.i; A.5.b.47.i; A.7.b.47.i; A, 9.b.47.i; A.100.b.47.i; A .101.b.47.i; A.102.b.47.i; A.103.b.47.i; A.104.b.47.i; A.105.b.47.i; A .106.b.47.i; A.107.b.47.i; A.108.b.47.i; A.109.b.47.i; A.110.b.47.i; A. .lll.b.47.i; A.112.b.47.i; A.113.b.47.i; A.114.b.47.i; A.115.b.47.i; A .116.b.47.i; A.117.b.47.i; A.118.b.47.i; A.119.b.47.i; A.120.b.47.i; A. .121.b.47.i; A.122.b.47.i; A.123.b.47.i; A.124.b.47.i; A.125.b.47.i; A. .126.b.47.i; A.127.b.47.i; A.128.b.47.i; A.129.b.47.i; A.130.b.47.i; A .131.b.47.i; A.132.b.47.i; A.133.b.47.i; A.134.b.47.i; A.135.b.47.i; A .136.b.47.i; A.137.b.47.i; A.138.b.47.i; A.139.b.47.i; A.140.b.47.i; A .141.b.47.i; A.2.b.48.i; A.3.b.48.i; A.4.b.4S.i; A.5.b.48.i; A .7.b.48.i; A.9.b.48.i; A.100.b.48.i; A.101.b.48.i; A.102.b.48.i; A .103.b.48.i; A.104.b.48.i; A.105.b.48.i; A.106.b.48.i; A.107.b.48.i; A .108.b.48.i; A.109.b.48.i; A.110.b.48.i; A.lll.b.48.i; A.112.b.48.i; A .113.b.48.i; A.114.b.48.i; A.115.b.48.i; A .116.b.48.i; A.117.b.48.i; A.118.b.48.i; A.119.b.48.i; A.120.b.48.i; A. .121.b.48.i; A.122.b.48.i; A.123.b.48.i; A.124.b.48.i; A.125.b.48.i; A .126.b.48.i; A.127.b.48.i; A.128.b.48.i; A.129.b.48.i; A.130.b.48.i; A .131.b.48.i; A.132.b.48.i; A.133.b.48.i; A.134.b.48.i; A.135.b.48.i; A. .136.b.48.i; A.137.b.48.i; A.138.b.48.i; A.139.b.48.i; A.140.b.48.i; A. .141.b.48.i; A.2.b.49.i; A.3.b.49.i; A.4.b.49.i; A.5.b.49.i; A .7.b.49.i; A.9.b.49.i; A.100.b.49.i; A.101.b.49.i; A.102.b.49.i; A .103.b.49.i; A.104.b.49.i; A.105.b.49.i; A.106.b.49.i; A.107.b.49.i; A. .108.b.49.i; A.109.b.49.i; A.110.b.49.i; A.lll.b.49.i; A.112.b.49, i; A .113.b.49.i; A.114.b.49.i; A.H5.b.49.i; A.116.b.49.i; A.117.b.49.i; A .118.b.49.i; A.119.b.49.i; A.120.b.49.i; A.121.b.49.i; A.122.b.49.i; A. .123.b.49.i; A.124.b.49.i; A.125.b.49.i; A.126.b.49.i; A.127.b.49.i; A .128.b.49.i; A.129.b.49.i; A.130.b.49.i; A.131.b.49.i; A.132.b.49.i; A .133.b.49.i; A.134.b.49.i; A.135.b.49.i; A.136.b.49.i; A.137.b.49.i; A .138.b.49.i; A.139.b.49.i; A.140. b.49.i; A.141.b.49.i; A.2.b.50.i; A.3.b.50.i; A.4.b.50.i; A.5. b.50.i; A.7.b.50.i; A.9.b.50.i; A.100.b.50.i; A.101.b.50.i; A.102. b.50.i; A.103.b.50.i; A.104.b.50.i; A.105.b.50.i; A.106.b.50.i; A.107. b.50.i; A.108.b.50.i; A.109.b.50.i; A.110.b.50.i; A.lll.b.50.i; A.112. b.50.i; A.U3.b.50.i; A.114.b.50.i; A.115.b.50.i; A.116.b.50.i; A.117. b.50.i; A.118.b.50.i; A.119.b.50.i; A.120.b.50.i; A.121.b.50.i; A.122. b.50.i; A.123.b.50.i; A.124.b.50.i; A.125.b.50.i; A.126.b.50.i; A.127. b.50, i; A.128.b.50.i; A.129.b.50.i; A.130.b.50i; A.131.b.50.i; A.132.b. 50.i; A.133.b.50.i; A.lS ^ b.SO.!; A.135.b.50.i; A.136.b.50.i; A.137.b. 50.i; A.13S.b.50.i; A.139.b.50.i; A.140.b.50.i; this paper standard 1r national storehouse standard (CNS) Λ4 said grid (public縻) -188-44266 6 3

In dn • Co, dt Printed by the Shellfish Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs. 5. Description of the invention (186) 51.i; A.4.b.51.i; A.5.b.51.i; A.7, b.51.i; A.9.b.51.i; 'A.100.b .51.i; A.IOl.b.Sl.i; A.102.b.51.i; A.103.b.51.i; A.104.b.51.i; A.105.b .51.i; A.106.b.51.i; A.107.b.51.i; A.108.b.51.i; A.109.b.51.i; A.110.b .51.i; A.lll.b.51.i; A.112.b.51.i; A.113.b.51.i; A.114.b.51.i; A.115.b .51.i; A.116.b.51.i; A.117.b.51.i; 5 A.118.b.51.i; A.119.b.51.i; A.120. b.51.i; A.121.b.51.i; A.122.b.51.i; A, 123.b.51.i; A.124.b.51.i; A.125. b.51.i; A.126.b.51.i; A.127.b.51.i; A.128.b.51.i; A.129.b.51.i; A.130. b.51.i; A.131.b.51.i; A.132.b.51.i; A.133.b.51.i; A.134.b.51.i; A.135. b.51.i; A.136.b.51.i; A.137.b.51.i; A.138.b.51.i; A.139.b.51.i; A.140. b.51.i; A.141.b.51.i; A.2.x.46.i; A.3.x.46Λ; A.4.x.46i; A.5.x.46. i; A.7.x.46.i; A.9.x.46.i; A.100.x.46.i; LO Α.101.χ.46.ί; A.102.x.46 .i; A.103.x.46.i; A.104.x.46.i; A.105.x.46.i; A.106.x.46.i; A.107.x.46 .i; A.108.x.46.i; A.109.x.46.i; A.110.x. 46.i; A.lll.x.46.i; A.112.x.46.i; A.113.x.46.i; A.114.x.46.i; A.115.x. 46.i; A.116.x.46.i; A.117.x.46.i; A.118.x.46.i; Α.119.χ.46.Ϊ; A.120.x. 46.i; A.121.x * 46.i; A.122.x.46.i; A.123.x.46.i; A.124.x.46.i; A.125.x. 46.i; A.126.x.46.i; A.127.x.46.i; A.128.x.46.i; A.129.x.46.i; A.130.x. 46.i;: 5 Α.131.Χ.46Λ; A.132.x.46.i; A.133.x.46.i; A.134.x.46.i; A.135.x. 46.i; A.136.x.46.i; A.137.x.46.i; A.138.x.46.i; A.139.x.46.i; A.140.x. 46.i; A.141.x.46.i; A.2.x.47.i; Α.3.Χ.47.Ϊ; A.4.x.47.i; A.5.x. 47.i; A.7.x.47.i; A.9.x.47.i; A.100.x.47.i; A.101.x.47.i; A.102.x. 47.i; A.103.x.47.i; A.104.x.47.i; A.105.x.47.i; A.106.x.47.i; A.107.x. 47.i; A.108.x.47.i; A.109.x.47.i; A.110.x.47.i; A.lll.x.47.i; A.112.x. 47.i; Α.113.χ.47.Ϊ; [〇A.114.x.47.i; A.U5.x.47.i; A.116.x.47.i; A.117. x.47.i; A.118.x.47.i; A; 119.x.47.i; A.120.x.47.i; A.121.x.47.i; A.122. x.47.i; A.123.x.47.i; A.124.x.47.i; A.125.x.47.i; A.126.x.47.i; A.127. x.47.i; A.128.x.47.i; A.129.x.47.i; A.130.x.47.i; A.131.x.47.i; Α.132. Χ.47.Ϊ; A .133.x.47.i; A.134.x.47.i; A.135.x.47.i; A.136.x.47.i; A.137.x.47.i; Α .138. × .47.Ϊ; Α.139.Χ.47.Ϊ; A.140.x.47.i; A.141.x.47.i; A.2.x.48.i; A .3.x.48.i; 5 A.4.x.48.i; A.5.x.48.i; Α.7.Χ.48.Ϊ; A.9.x.48.i; A.100.x.48.i; A.101.x.48.i; A.102.x.48.i; A.103.x.48.i; A.104.x.48.i; A.105.x.48.i; A.106.x.48.i; Al〇7.x.48.i; A.108.x.48.i; A.109.x.48.i; A.110.x.48.i; A.lll.x.48.i; A.112.x.48.i; A.113.x.48.i; A.114.x.48.i; A.115.x.48.i; A.116.x.48.i; A.117.x.48.i; A.118.x.48.i; A.119.x.48.i; A.120.x.48.i; A.121.x.48.i; A.122.x.48.i; A.123.x.48.i; A.124, x.48.i; Α.125.Χ.48.Ϊ; A.126.x.48.i; 0 A.127.x.48.i; A.128.x.48 * i; A.129.x.48.i ; A.130.x.48.i; A.131.x.48.i; A.132.x.48.i; A.133.x.48.i; A.134.x.48.i ; A.135.x.48.i; A.136.x.48.i; A.137.x.48.i; A.138.x.48.i; A.139.x.48.i ; A.140.x.48.i; A.l41.x.48.i; A.2.x.49.i; A.3.x.49.i; A.4.x.49.i ; A.5.x.49.i; A.7.x.49.i; A.9.x.49.i; A.100.x.49.i; A.101.x.49.i ; A.102.x.49.i; A.103.x.49.i; Α.104.Χ.49.Ϊ; A.105.x.49.i; A.106.x.49.i ; A.107.x.49.i; A.108.x.49 .i; A.109.x.49.i; A.110, x.49.i; A.lll.x.49.i; A.112.x.49.i; A.113.x.49 .i; A.114.x.49.i; A.115.x.49.i; A.116.x.49.i; A.117.x.49.i; A.118.x.49 .i; A.119.x.49.i; A.120.x.49.i; A.121.x.49.i; A.122.x.49.i; A.123.X.49.1 ; A.124.x.49.i; Α.125.Χ.49.Ϊ; A.126.x.49.i; A.127.x.49.i; A.128.x.49.i ; A.129.x.49.i; A.130.x.49.i; A.131.x.49.i; A.132.x.49.i; A.133.x.49.i ; Α.134.Χ.49.Ϊ; Α.135.Χ.49.Ϊ; A.136.x.49.i; A.137.x.49, i; A.138.x.49.i ; A.139.x.49.i; A.140.x.49.i; A.141.x.49.i; A.2.x.50.i; A.3.x.50.i ; A.4.x.50.i; A.5.x.50.i; A.7.x.50.i; Α.9.χ.50Λ; Al〇0.x.50.i; A .101.x.50.i; A.102.x.50.i; A.103.x.50.i; A.104.x.50.i; A.105.x.50.i; A .106.x.50.i; A.107.x.50.i; A.10S.x.50.i; A.109.x.50.i; A.110.x.50.i; A. .lll.x.50.i; A.112.x.50.i; A.113.x.50.i; A.114.x.50.i; A.115.x.50.i; A .116.x.50.i; A.117.x.50.i; A.118.x.50.i; A.119.x.50.i; A.120.x.50.i; A .121.x.50.i; A.122.x.50.i; A.123.x.50.i; A.124.x.50.i; A.125.x.50.i; A .126.x.50.i; A-l27.x.5〇.i; A.128.x.50.i; A.129.x.50.i; A.130.x.5O.i; A.131.x.5 0.i; A.132.x.50.i; A.133.x.50.i; A.134.x.50.i; A.135.x.50.i; A.136.x. 50.i; A.137.x.50.i; A.138.x.50.i; A.139.x.50.i; A.140.x.50.i; A.141.x. 5G.i; Α.2.χ.51.Ϊ; A.3.x.51.i; A.4.x.51.i; A.5.x.51.i; A.7.x. 51.i; A.9.x.51.i; This paper size is applicable to the Chinese Standard House Standard (CNS) Λ4% (public waste) — 426663,-Member of the Central Standards Bureau of the Ministry of Economic Affairs, Consumer Cooperation, Du Printing 5 Description of the invention (187) A.100.x.51.i; A.lOl.x.Sl.i; A.102.x.51.i; A.103.x.51i; A.104.x, 51 * i; A.105.x.5Li; 'A-106, x.51.i; A.107.X.5U; A.108_x.51_i; Α · 109.χ · 51 · ί; A, lKXx .5U; Α · 111'χ · 51.ί; A.11.2.x.51.i; A.113.X-51J; A.114.x.51.i; A.115.x.51, i ; A.116.x.51, i; A.117, x.51.i; A.118.x.5Li; ΑΛ19.Χ.51Λ; A.120, x.51.i; A.12Lx.51 .i; A.122.x.5Li; A.123.x, 5Li; 5 Α.124.Χ.51Λ; Α.125.Χ.5Π; A-126.x.51.i; A.127. x.51.i; A.12S.x.51.i; A, 129.x.51.i; Α130 · χ · 51.ί; A.131.x.5Li; A-132.x. 51.i; A.133.x.51.i; A.134.x.51.i; A.135.x.51i; A.136.x.5Li; AJ37.x.51.i; A. 138, x.51.i; A.139.x.51i; A.140.x.51.i; A.141, x.51.i; A.2.y.46.i; A.3. y .46.i; A.4.y, 46.i; A.5.y.46i; A.7.y.46.i; A.9.y.46.i; A.100.y.46 .i; A.101.y.46.i; A.102.y.46.i; A + 103.y.46.i; A.104.y.46.i; A.105.y * 46 , i; A.106.y.46.i; 10 A.107.y.46, i; A.108.y.46.i; A.109.y, 46.i; A.110.y. 46.i; A.lll.y.46i; A.112.y.46J; A * 113.y.46 * i; A.114.y.46.i; A.115y.46.i; A. 116.y.46.i; A.117.y.46i; A.118.y.46.i; A.119.y, 46.i; A.120.y.46.i; A, 121. y.46 * i; A.122.y.46.i; A123.y, 46.i; A.124.y.46.i; A.125.y.46.i; A.126.y. 46.i; A.127.y.46.i; A, 128.y.46.i; A.129.y.46i; A.130.y.46J; A.131.y.46.i; A.132.y.46.i; A.133.y.46.i; A.134.y.46.i; A.135.y.46j; A, 136.y.46.i; 15 A .137.y, 46.i; A.138.y, 46.i; A.139.y.46 * i; A.140.y.46.i; A.141.y.46.i; A. .2.y.47.i; Α3.γΛ7Λ; A.4.y, 47.i; A.5.y.47, i; A, 7.y.47 * i; A, 9.y.47 .i; A.100.y, 47, i; A.101.y.47, i; A.102.y.47.i; A.103.y.47.i; A.104.y.47 .i; A.105.y.47.i; A.106.y.47, i; A.107.y.47.i; Al〇ay.47.i; A.109.y.47.i ; A, ll〇.y.47.i; A.lU.y, 47.i; A.U2.yA7A; ΑΛ13.γΛ7Λ; A.114.y.47.i; A.115.y.47. i; A.116.y.47.i; A.117.y.47.i; A-118.y.47.i; A.119.y.47i; 10 A. 120.y.47.i; A.121.y, 47.i; A.122.v.47.i; A.123.y.47.i; A.124.yA7.i; A.125, y.47.i; A-126.y.47.i; A.127.y.47.i; A.128.y.47, i; A.129.y.47.i; A.130, y.47.i; A.131.y.47i; A.132 ^ .47.1; A.133.y.47.i; A.134.y, 47.i; A.135.y.47.i ; A.136.y.47.i; A.137.y.47.i; A * 138.y.47.i; A.139.y.47a; A.140, y.47.i; A , 141.y.47.i; A.2-y.48i; A.3.y.48.i; A.4.y.48.i; Α3, γΛ8Λ; A.7.y.48.i ; A.9.y.48.i; A.100.y.48.i; A.101.y.48.i; A, 102.y, 48.i; Ϊ5 A.103.y.48. i; A.104.y.48.i; A / L05.y.48_i; A.106.y.48, i; A-107.y-48.i; A.108.y.48.i; A.109, y.48.i; A.110, y.48a; A.lll.y.48, i; A.112.y, 4S.i; A.113.y.48.i; A. 114.y.48.i; A.115, y.48.i; A.116.y; 48.i; A.117.y.48.i; A.118.y.48.i; A- 119, y.48.i; A.120.y.4S.i; A, 121.y.48.i; A.121y.4S, i; A.123.y.48.i; A.124. y.48.i; A.125.y.48.i; A.126.y.48.i; A.127.y.48i; A.128.y.48.i; A.129, y. 48.i; A.130.y.48.i; A.13Ly.48.i; A.132.y-48.i;: S〇A.133.y.48.i; A.134.y , 48.i; A135, y.48.i; A.136.y.48.i; ΑΛ37.γΑ8Α; AJ38-y.48, i; A.139, y.48j; A.140.y.48 .i; Α.141 · 7,48.i; A.2.y.49.i; Α3ύΛ9λ; Α .γΛ9Α; A.5.y.49.i; A.7, y.49, i; A.9.y, 49.i; A, 100.y.49.i; A.101.y.49 .i; A.102.y, 49.i; A.103.y.49.i; A104.y, 49-i; A.105.y.49.i; A, 106.y.49.i ; A, 107.y.49.i; A.108.y.49.i; A.109.y.49.i; A.110.y.49.i; A.lll.y, 49, i ; A-112, y.49, i; A, 113.y, 49.i; ΑΛ14.γΛ9Λ; ΑΛ15.νΛ9Λ;: 5 A.H6.y.49i; A.117.y.49.i; A .118, y.49, i; A.119.y.49.i; A.120.y.49.i; A.121.y.49, i; A.122, y.49i; A, 123y .49, i; A, 124.y.49.i; A.125.y.49.i; A.126.v.49i; ΑΛ27.ν.49ά; A.128.y.49.i; A .129.y.49, i; A.130, y, 49i; A.131.y.49.i; A.132.y.49.i; A.133.y, 49.i; A, 134 .y.49.i; Ai135.y.49.i; A.136.y.49.i; A.137.y.49.i; A.138.y, 49.i; A.139.y -49.i; A.l40.y.49, i; A.l41.y.49.i; A.2.y.50.i; A.3.y * 50.i; A, 4.y .50, i; A.5.y.50.i; A.7, y.50.i; A.9.y.50.i; A.100.y.50, i; A.10Ly.5Q .i; A.102.y.50.i; A.103.y.50.i; A.104.y.50.i; A.105.y.50J; A.106.y.50.i ; A-107.y.50.i; A.108.y.50.i; A.109.y, 50.i; A.llO.y.SO.i; A.lll.y.50.i ; A.112.y, 50.i; A.113.y.50.i; A.114.y.50.i; A.115-y.50, i; A, 116.y \ 50.i ; A.117.y.50.i; A.118.y.50.i; A.119.y.50.i; A.120.y .50.i; A.121.y.50.i; A, 122.y.50.i; A.123.y.50.i; A.IZi.y.SO.i; A.125.y .50.i; A.126, y.50.i; A.127.y, 50.i; A.128, y.50.i; 45 A-129.y.50.i; A.130. y * 50, i; A.131.y.50.i; A.132, y.50.i; A.133.y.50 * i; A.134.v.50.i; A.135. y.50.i; A.136.y.50.i; A.137.y * 50.i; A.138.y.50.i; A.139.y.50.i; A.140. y.50, i; A.141.y.50.i; A.2.y.51.i; A.3.y, 51.i; A.4.y * 51.i; A.5. y.5Li; A.7.y, 51.i; Af9.vol.i; A, 100.y5U; A, 10Ly, 5U; A.102.y-51i; A.103.y.51.i; A, 104, y. 5U; A. 105: y. 51.i; This paper size is applicable to the Central Family Standard Guide (CNS) 8 and 4 (2 丨 () &gt; &lt; 297 mm) _ — please k. read

Binding Grab ^^ S_0-g-^ —— ^ fS- Μ Central Standards of the Ministry of Economic Affairs of the People's Republic of China Cooperative Cooperative Print 4 2 6 6 6 3 ^ A7 &gt; B7 V. Description of the Invention (188) A, 106.y. oU; Al〇Ay.5U; ΑΛ08.ν.51Λ; A, 109.y, 51.i; A.ll〇.y.51.i; A.lll.y.51.i; A.X12.y .5Li; A.113.y.5Li; A.IH.yol.i; A.115.y.51.i; A, 116.v.5Li; A.117.y.5Li; A118.y.51 .i; A.119.y.51.i; A.120.y.5l .i; A.121.y.5U; A.122.y.51.i; A.123.y.51.i ; A.124.y.51.i; A.125.y.51 j; A.126.V.51.1; A.127.y.51.i; A.12S-y.5Li; A.129. y.5Li; A.130.y.5Li; A.131.y.5Li; A-132.y.51.i; A, 133.y.51.i; A.134.y, 51.i; A.135.y.5U; A.136.y.51.i; A.137.y.5Li; AJ38.y.51.i; A.139.y.51.i; A.140, y. 5Li; A.141.y.51.i; A * 2.z.46.i; A.3 * z.46.i; A.4.z.46.i; A, 5.z.46. i; A.7.z-46, i; A.9.z, 46.i; A.100.z.46.i; A.101.z.46.i; A.102.z.46. i; A.103.2.46.1; A.104.z.46.i; A.105.z.46.i; A.106.z.46.i; A.107.z.46.i; Α. 108-2.46Λ; A.109.z.46.i; A.110.z.46.i; Α.Π1.2.46.Ϊ; A.112.z.46.i; A.113.z.46 .i; A.114.2.46.1; A.115 * z.46.i; A.116.z.46.i; A.117.z.46.i; A.118.z.46.i; A. .119.z.46i; A.120.z.46i; A, 121.z.46.i; A.122.z.46.i; A.123, z.46i; A.124.z.46.i; ΑΛ25.ZOΛ6Α; A.126.z.46. i; ΑΛ27.ζΑ6Λ; A.128.z, 46.i; A.129.z.46.i; A.130.z.46.i; A.13Lz.46.i; A.132.z. 46.i; A.133.z.46-i; A.134.z.46.i; A.135.z.46.i; A * 136.z * 46, i; A.137.z. 46.i; ΑΛ38.Z.46.Ϊ; A, 139.z.46.i; Α.140.Z.46Λ; A.141.z * 46 * i; A.2.z.47.i; A3.z.47i; ΑΛ, ζΑ7.ϊ; A.5.z.47.i; A.7, z.47.i; Α.9.2.47.Ϊ; A.100, z.47i; A. 101.z.47-i; A.102.z.47.i; A.103.z.47.i; A.104.z.47, i; A.105.z.47, i; A. 106.Z.47J; A.107.z.47.i; A.108 * z.47i; ΑΛ09.2.47.Ϊ; A.110.z.47.i; Α.111.ζΑ7λ; ΑΛΙζζΑ7.ι; ΑΛ13.ζΛ7: ι; ΑΛ14.ζΛ7λ; A.115.z.47.i; A.116.z, 47.i; ΑΛ17.ζΑ7λ; A.118.z, 47.i; Α.119.ζ. 47.ί; ΑΛ20.ζΛ7Λ; A.121.z.47i; A.122.z, 47.i; A.123.z.47.i; A.124.z.47.i; A, 125. z, 47.I; Α.126.Z.47.Ϊ; A.127.z.47.i; Α.128, ζ.47Λ; A.129.z.47.i; A.130.z. 47.i; ΑΛ31.2.47.1; A.132.z, 47.i; A * 133.z.47.i; A.134.z.47.i; A.135, z.47.i; A.136-z.47j; A.137.z.47.i; A.138.z.47.i; A.139.z.47.i; A.140.z.47.i; Α. 141.Z.47Λ; A, 2, z.4 8.i; A.3, z.48.i; A.4 * z.48.i; A.5.z.48.i; A.7.z, 48.i; A.9.z. 48, i; A.100.z.48.i; A.101.z.48.i; A.102.z, 48.i; A-103.z, 48.i; A-104.z. 48.i; A.105.z.48.i; ΑΛ06.ζΑ8λ; A.107.z.48.i; A.108.z, 48.i; A + 109.z.48 * i; A. llO.z.48.1; A.lll.z.48.i; A, 112.z.48.i; A.113.z.48.i; A, 114.z.48.i; A.115, z.48.i; A, 116 * z.48.i; A.117.z.48.i; A.118.z.48.i; A.119.z.48.i; A.120. z.48.i; Α.121.Z.48Λ; A.122.z.48i; A.123 * z, 48.i; A.124.z.48.i; A.125.z.48. i; A, 126.z.48.i; A.127.z.48.i; A.128.z.48.i; A.129.z, 48i; A.130.z.48.i; A.131.z.48: i; A.132.z.48a; A.133.z-48.i; A.134.Z.48J; A.135, z.48.i; A.136. z.48.i; A.137.z-48.i; ΑΛ38.ζΛ8λ; A.139.Z.48.I; A.140.2.48.i; A.X41.z, 48i; A.2. z.49.i; A.3.2.49.i; ΑΛ, ζΛ9Λ; A.5 * z, 49.i; Α.7.Z.49.Ϊ; A.9.Z.49.1; ΑΛΟΟ.ζΛ9Λ; ΑΛ01.ζΛ9Λ; Α.102.Z.49.Ϊ; A.103.z.49.i; A.104.z.49.i; A.105.z.49.i; A.106.z. 49.i; Α.107.2.49.Ϊ; A.108.z.49.i; A.109.z.49a; A.llO.z.49.1; ΑΛ11.ζ.49λ; A.112.z. 49.i; A.113.2.49, i; Α.114.2.49Λ; A.115.z, 49.i; Α.116 · ζ · 49_ί; Α · 117 · ζ '49 · ί; Α · 118 · ζ.49Λ; A.119.z.49, i; Α · 120.2 · 49 · ί; Α-121 · ζ'49 · ί; A.122.z.49.i ΑΛ23.Z.49.I; A.124-z.49.i; A.125.z.49.i; A.126, z, 49i; ΑΛ27.ζΛ9Α; A.1282_49j; Α129.ζ · 49 · Ί; Α · 130.ζ · 49 · ί; A.131, z.49.i; Α.132 · ζ · 49.ί; Α · 133 · ζ · 49-ί; A.134.2.49, i ; A.135.z.49i; A.136.z.49.i; A.137.z.49.i; A.138.z, 49i; A.139.2.49.i; ΑΛ40.Z.49.1 ; A.14Lz, 49.i; A.2.z.50.i; A.3.z.50 * i; A.4.z.50.i; A.5.z.50.i; A .7.z.50a; A.9.z, 50.i; A.100.z50.i; A.101.2.5〇.i; ΑΛ02.ZO.50Λ; A.103.z.50.i; A.104 * 2.50.i; A.105.Z.50Λ; A.106.Z.50Λ; A.107 * z.50.i; A.108.z.50.i; AJ09.z.50. i; A.110.z, 50.i; A.111.2.50.i; Α.112.2.50.Ϊ; A.113.z50a; A.114.z.50.i; A, 115.z. 50, i; A, 116.z.50.i; A.117.z.50.i; A_118.z.50.i; A.119.z, 50.i; A.120, z.50. i; A.121.z.50.i; A, 122.z.50.i; A, 123.z.50, i; A.124.z.50-i; A.125 * z.50. i; A.126.2,50.i; A.127.2.50a; ΑΛ28.2.50.Ϊ; A.129.z.50, i; A.130, z * 50.i; A.131.z.50 * i; A.132 * z.5〇.i; A.133, z * 50.i; A.134 * z.50.i; A.135.Z.50Λ; A.136.2.50.i; A.137.z.50.i; A.138.z50.i; A.139, z.50, i; AM0.z50A; Α.141.2.50.Ϊ; A.2.z.51.i; A3.Z.51 .i; A.4, z.51, i; A.5.2.5Li; A7.z.5Li; A.9.z.51.i; A.100.2.51.1; ΑΛ01.2.51. Ϊ; A.102.z.51.i; A.103.z.51.i; A.104.z.51.i; A.105, z.5Li; A, 106.z.51.i; A.107.z, 51.i; A, 108.z.51.i; A, 109.z.51.i; A.110.z.51.i; A.lll.z.SLi; this paper Applicable standards 丨 Change to National Standard China (C, NS) A.4 (210X297) _ 191 —

^ 266 63 A1 ^ B7 Printed by the Consumer Cooperatives of the Central Bureau of Standards of the Ministry of Economy .i; A.115.z.51.i; A.X16.z.51.i; A.117.z.51.i; • Α.118.2.51.Ϊ; A.119.z-51. i; A.120.z.51.i; A.121.z.51.i; A.122.z.51.i; A.123.z.51.i; A. 124.ZZ.51. Ϊ; A.125.z.51.i; A.126.z.51.i; A.127.z.51.i; A.128.z.51.i; A.129.z.51. i; A.130.2.51.Ϊ; A.131.z.51.i; A.132.z.51.i; A.133.z.51.i; A.134.z.51.i; A.135.z.51.i; 5 A. 136.2.51.1; A.137.z.51.i; A.138.z.51.i; A.139.z.51.i; A.140 .z.51.i; A.141.z.51.i; Α.2.Α.46.Ϊ; Α.3.Α.46.Ϊ; Α.4.Α.46.ί; Α.5 .Α.46.Ϊ; A.7.A.46.i; A.9.A.46.i; Α-100.Α.46.Ϊ; Α.101.Α.46Λ; A.102.A .46.i; A.103.A.46.i; A.104.A.46.i; Α.105.Α.46.Ϊ; Α.106.Α.46.Ϊ; Α.107.Α .46.Ϊ; Α.108.Α.46.Ϊ; A.109.A.46.i; Α.110.Α.46.Ϊ; A.lll.A.46.i; Α.Π2.Α .46.Ϊ; A.113.A.46.I; A.114.A.46.i; A.115.A.46.i; Α.116.Α.46.Ϊ; Α.117.Α .46.Ϊ; A.118.A.46.i; 10 A.119.A.46.:; Α.120.Α.46.Ϊ; Α.121.Α.46.Ϊ; Α.122. Α.46.Ϊ; Α.123.Α.46.Ϊ; A.12 4.A.46.i; Α.125.Α.46.Ϊ; Α.126.Α.46.Ϊ; Α.127.Α.46.Ϊ; Α.128.Α.46.Ϊ; Α. 129.Α.46.Ϊ; ΑΛ30.Α.46.1; Α.131.Α.46.Ϊ; A.132.A.46.i; Α.133.Α.46.Ϊ; Α.134.Α. 46.Ϊ; Α.135.Α.46.Ϊ; Α.136.Α.46.Ϊ; A.137.A.46.i; Α.138.Α.46.Ϊ; A.139.A. 46.i; Α.140.Α.46Λ; Α.141.Α.46.Ϊ; Α.2.Α.47.Ϊ; Α.3.Α.47.Ϊ; Α.4.Α.47. Ϊ; A.5.A.47J; Α.7.Α.47.Ϊ; Α.9.Α.47.Ϊ; Α.100.Α.47.Ϊ; 15 Α.101.Α.47.Ϊ ; A.102.A.47.i; Α.103.Α.47.Ϊ; Α.104.Α.47.Ϊ; Α.105.Α.47.Ϊ; Α.106.Α.47.Ϊ ; Α.107.Α.47.Ϊ; Α.108.Α.47.Ϊ; Α.109.Α.47.Ϊ; Α.110.Α.47.Ϊ; A.Ul.A.47.i A.112.A.47.1; Α.113.Α.47.Ϊ; Α.114.Α.47.Ϊ; Α.115.Α.47.Ϊ; A.U6.A.47i; A.117 .A.47.i; A.118.A.47.i; Α.119.Α.47.Ϊ; A.120.A.47.i; Α.121.Α.47.Ϊ; A.122 .A.47.I; Α.123.Α.47.Ϊ; Α.124.Α.47.Ϊ; A.125.A.47, i; Α.126.Α.47.Ϊ; Α.127 .Α.47.Ϊ; Α.128.Α.47.Ϊ; Α.129.Α.47.Ϊ; Α.130.Α.47.Ϊ; 20 Α.131.Α.47.Ϊ; A. 132.A.47.i; ΑΛ33.Α.47.Ϊ; Α.134.Α.47.Ϊ; Α.135.Α.47.Ϊ; Α.136.Α.47.Ϊ; Α.137. Α.47.Ϊ; A.138 .A.47.i; A.139.A.47.i; A.140.A.47.i; A.141.A.47.i; A.2.A.48.i; A.3 .A.48.I; Α.4.Α.48.Ϊ; Α.5.Α.48.Ϊ; Α.7.Α.48.Ϊ; A.9.A.48.1; A.100.A .48.i; A.101.A.48.1; Α.102.Α.48.ί; Α.103.Α.48.Ϊ; Α.104.Α.48.Ϊ; Α.105.Α.48 .Ϊ; A.106.A.48.i; Α.107.Α.48.Ϊ; A.108.A.48a; Α.109.Α.48.Ϊ; Α.110.Α.48.Ϊ ; A.lll.A.48.i; A.112.A.48.i; 25 Α.Π3.Α.48.Ϊ; Α.114.Α.48.Ϊ; A.115.A.48. i; A.116.A.48.i; A.117.A.48.i; Α.118.Α.48.Ϊ; Α.119.Α.48.Ϊ; Α.120.Α.48. Ϊ; A.121.A.48.i; A.122.A.4S.I; Α.123.Α.48.Ϊ; Α.124.Α.48.Ϊ; Α.125.Α.48. Ϊ; Α.126.Α.48.Ϊ; Α.127.Α.48.Ϊ; A.128.A.48.i; Α.129.Α.48.Ϊ; Α.130.Α.48. Ϊ; Α.131.Α.48.Ϊ; Α.132.Α.48.Ϊ; Α.133.Α.48.Ϊ; Α.134.Α.48.Ϊ; A.135.A.48. i; A.136.A.48.i; A.137.A.48.i; Α.138.Α.48.ί; Α.139.Α.48.Ϊ; Α.140.Α.48. 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Public epidemic) _ _ A7 B7 Printed by the Consumers' Cooperatives of the Central Procurement Bureau of the Ministry of Economic Affairs 5. Description of the invention (190) A.113.A.51 .i; A.114.A.51.i; A.115.A.51.i; A.116.A.51.i; A.117.A.5U; A.U8.A.5U; • A.119.A.51.i; A.120.A.5U; A.121.A.5U; Α.122.Α.51.Ϊ; Α.123.Α.51.Ϊ; Α.124. 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F.51.i; A.108.F.5U- A.109.F.51.i; A.110.F.51.i; A.lll.F.51.i; A.112.F.51.i; A. 113.F.51.i; A.114.F.51.i; A.115.F.51.i; A.116.F.51.i; A.117.F.51.i; A. 118.F.51.i; A.119.F.5l.i; A.120.F.51.i; A.121.F.51.i; A.122.F.51.i; A. 123.F.5U; A.124.F.51.i; A.125.F.5U; A.126.F.5U; A.127.F.51.i; A.128.F.5U; A.129.F.51.i; A.130.F.51.i; A.131.F.51.i; A.132.F.5U; A.133.F.5U; A.134. F.51.i; A.135.F.51.i; A.136.F.51.i; A.137.F.5l.i; A.138.F.51.i; A.139. F.5U; A.140.F.511; A.Ul.F.Sl.i; ——} The paper size is applicable to the threshold of the home garden (CNS M4 specification (2! () X 297 male) _ _ 4 2 66 6 3 ν Α7 __Β7_ V. Description of the invention (195) Salts and hydrates The composition of the present invention optionally contains a salt of the compound of the present case, especially a pharmaceutically acceptable non-toxic salt, which contains, for example, Na +, Li +, K +, C a ++ and Mg ++ »Such salts can also include bangs obtained by mixing appropriate cations (such as metal ion, earth metal ion or ammonium ion with quaternary amine ion) and acid anion moiety (typically Wi Carboxylic acid). If a water-soluble salt is expected, a monovalent salt is preferred. Typically, a metal salt is prepared by reacting a metal hydroxide with a compound of the present invention. Examples of metal salts made in this way are those containing Li +, Na + and K +. Adding an appropriate metal compound from a solution of a more soluble salt can precipitate a less soluble metal salt. In addition, salts can also be formed by adding an acid to a basic center (preferably Gi amine) or to an acidic group (such as El), for example, an organic acid and an inorganic acid (such as, HBr, H2S04) or an organic sulfonic acid. Finally, it should be understood that the compounds of the present invention included in the composition of this case may be undissociated, or in the form of zwitterions, or in the case of hydrates, mixed with stoichiometric water. Printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs. Within the scope of the present invention are salts of the parent compound with one or more amino acids. Any of the above amino acids are suitable, especially natural amino acids as a protein component, but the amino acids are preferably those with a side chain containing an acidic or acidic group, such as lysine, arginine or glutamic acid Glycine, or those with neutral groups, such as glycine, serine, threonine, alanine, isoleucine or leucine. ^ Paper size applies Chinese National Standard (CNS) Λ4 specification (210X 297 mm) ~ -198-4 2 66 6 3 Λ: Α7 Β7 V. Description of the invention (196) Inhibition method of ceramide One aspect relates to a method for inhibiting neuraminidase activity, which comprises the step of treating a sample that may contain neuraminidase with a compound of the present invention. The composition of the present invention is an inhibitor of neuraminidase, and the intermediate of the inhibitor may have the following description. The inhibitor binds to a position on the surface or in the hole of the neuraminidase (this position is specific to the structure of the neuraminidase). The combination of the composition with neuraminidase has different degrees of reversibility. Those compounds that are substantially irreversibly bound are ideal substances for use in the methods of the present invention "-Once labeled, this composition that is substantially irreversibly bound can be used as a probe to detect neuraminidase. Therefore, the present invention is a method for detecting a sample that may contain neuraminidase, which includes the step of treating a compound that may contain neuraminin with a composition containing a compound of the present invention that is bound to a label Acid-glucosidase sample; observe the effect of the sample on the activity of the label "Appropriate labels are well known in the analytical field, including stable free radicals, fluorophores, radioisotopes, enzymes, chemiluminescent groups and chromophores. The compounds in this case are labeled with functional groups (such as hydroxyl or amine) using conventional methods. In the present invention, the samples that may contain neuraminidase include natural or artificial materials, such as living bodies; tissue or cell culture; biological samples, such as biomass samples (blood, serum, urine, cerebral spinal cord Fluid, tears, sputum, saliva, tissue samples, etc.); laboratory samples; food, water or air samples; biological product samples, such as cell extracts, especially recombinant cells (which can synthesize expected glycoproteins, etc.) .Typically, the possible sample contains the paper produced by Shenzhou, which is fully applicable to Chinese National Standards (CNS) M specifications (210 × 297 mm) Please read the precautions on the back before printing by the Consumers' Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs. -199-4 2β6 6 3: a? __ * ___ B7_ V. Description of the invention (197) An aminoglycosidase-containing organism is usually a pathogenic organism. For example, a virus. The sample can be stored in any water and organic A solvent / water mixture. The sample will contain living organisms, such as humans or human substances, such as cell cultures. The processing steps of the present invention include adding the composition of the present invention to the sample, or the group The precursor of the compound is added to the sample. This addition step includes any of the above methods of application. If necessary, the activity of neuraminidase after the composition is used can be detected by any method (including direct and indirect neuraminidase detection). Test method) Observation. Quantitative, qualitative and semi-quantitative detection of neuraminidase can be used. Typically "any one of the above screening methods is used, but any other method can also be used, for example, for the physiological properties of living organisms. Observation method. Organisms containing Neuraminidase printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs include bacteria (Vibrio cholerae * P. perforans, Streptococcus pneumonia and Arthrobacter sialophilus) and viruses (especially orthomyxovirus or paramyxovirus , Such as influenza viruses A and B, parainfluenza virus, mumps virus, Newcastle disease virus, poultry plague virus, and sendai virus) Neuraminidase that occurs or is found in these organisms The inhibitory effect of the activity is within the purpose of the present invention.

Fundamental Virology # (Raven Press, New York, 1986) Chapter 24. The compounds of the present invention are useful in the treatment or prevention of such infections in animals or humans. Examples of the aforementioned animals are ducks, rodents or pigs. However * when screening compounds that can inhibit influenza virus * it should be kept in mind that the results of enzyme analysis are not necessarily Consistent with cell tissue analysis results, such as-paper size applies Chinese national standards (CNS &gt; Λ4 specification (21 (Γχ 297 mm) '): -200-4266 6 3 at ^ _B7 V. Description of the invention (

Chandler et al., As shown in Table 1 of 1L ± '. Therefore, plaque reduction assay should be used as the first screening function. Neuraminic Acid Tungsten Inhibitor Screening The neuraminidase inhibitory activity of the composition of the present invention is screened by any technique known to evaluate enzyme activity. In this paper, the composition is typically first screened for its inhibitory effect on neuraminidase in vitro, and those with inhibitory activity are then screened for its in vivo activity. In vitro Ki (inhibition constant) is less than about 5X 1 0-βM, preferably less than about 1 X 1 0-7M, more preferably less than about 5 X 1 0-8M, and the composition is better for in vivo application . Useful in vitro screening has been detailed, so it will not be repeated here. 11; zstei η, M · r ο η et al .; 'N a ΐ ure', 3 6 3 (6 4 2 8): 41 8-423 (1993), especially page 4 2 0 column 2 3 The whole paragraph to page 41, paragraph 2 on page 21, explains Po tier M. et al .;

Analyt. Biochem., 94: 287-296 (1 9 7 9), a suitable extra hip analysis, which is Chong, AKJ et al .; `` Biochem. Biophys. Acta &quot;, 1 077: 65-7 1 (1 99 1). In addition, it is printed by the Consumer Cooperatives of the Central Government Bureau of the Ministry of Economic Affairs.

Colman, P.M. et al. W 92/06691 (Int.

App_ No, PCT / AU9 0/0050 1, Publication date April 30, 1992) Page 34, line 13 to page 35, line 16 describes another useful in vitro screening method. The in vivo screening method has also been described in detail, refer to Itzstein, M. ron et al .: op. Cit., Especially on page 4 21, column 2 full paragraph 1 to page 4 2 3, paragraph 2 first paragraph, And Colraan, PM, and others: op. This paper size is applicable to China National Standard (CNS) 8 4 specifications (210X297 mm) -201-A7 B7 426663 5. Description of the invention (1 &quot;) cit., Page 3 6 page 1 -38 lines • It illustrates suitable in vitro screening methods. ---------- Seed coat-(Please read the precautions on the back before you &quot; &quot;-this page) Xia · Medical composition and coating with the compound of the present invention and conventional carrier and Excipient adjustment map, and the carrier and excipient are selected according to general practice. Tablets will contain excipients, glidants, fillers, binders, etc. Aqueous formulations are made in sterile form and are usually isotonic if they are intended for parenteral use. All formulations optionally contain excipients * as described in Handbook of Pharmaceutical Excipients ^ (1986). Excipients include a mixture of ascorbic acid with other antioxidants, such as EDTA, carbohydrates, such as cyclodextrin, hydroxyalkyl cellulose, hydroxymethyl cellulose, stearic acid, and the like. The p Η of these formulations is about 3 to 11, but usually about 7 to 10 »-line 丨 \ J / Central Laboratories of the Ministry of Economic Affairs, Men ’s Consumer Consumption Collaboration, to print one or more compounds of the present invention (referred to herein as active ingredients) Used in a manner appropriate to the condition. Appropriate routes include oral, rectal, nasal, topical (including buccal and sublingual), vaginal and parenteral (including subcutaneous, intramuscular, intravenous, intradermal, intradural and epidural). There are different and better ways depending on the condition of the recipient. The advantage of the compound of the present invention is its oral bioavailability, so it can be administered orally without having to go through the lung or intranasal route. • Surprisingly, WO 9 1/16320, WO 92/0669 1 and the popularity of US Patent No. 5360817 Cold compounds can be administered orally or intraperitoneally. See examples 1 6 1 below. The active ingredient may also be used alone, and is preferably used as a pharmaceutical composition. b-scale is applicable to China National Standard (CNS) A4 specification (210X297 mm) -202-A7 B7 426663 V. Description of the invention (200) The composition of the present invention, veterinary or human, contains at least one active ingredient as defined above , And one or more acceptable carriers and any other medical ingredients. The carrier must be "acceptable", that is, compatible with the other ingredients in the composition and not harmful to the recipient. The composition includes the latter suitable for the aforementioned administration, preferably in unit dosage form, which can be prepared by any method known in the pharmaceutical industry. In general, techniques and compositions are known from Remington's Pharmaceutical Sciences (Mack Publishing Co., Easton, PA). These methods include the step of combining the active ingredient with a carrier (composed of one or more accessory ingredients). Usually, the active ingredient is uniformly and sufficiently mixed with a liquid carrier or a solid carrier fine powder or both, and then, if necessary, the product is formed into a composition. The composition suitable for oral administration of the present invention is dispersed Units, such as jiaoxiang or tablets (each containing a predetermined amount of active ingredient); powder or granules; solution or suspension (in aqueous or non-aqueous liquid): liquid emulsion in water or oil in water Liquid emulsion. The active ingredient can be in the form of pellets, paste or paste. The tablets printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs are produced by pressing or molding, and are optionally mixed with one or more auxiliary ingredients. Compressed tablets are made by pressing active ingredients (eg, powder or granules) in a free-flowing form in a suitable machine, and optionally mixed with a binding agent, lubricant, inert diluent, preservative, surfactant or dispersion Agent. Moulded tablets are moulded in a suitable machine with a mixture of active ingredients which are powdered and moistened with an emotional liquid diluent. These tablets can be optionally coated or scored. Slow release or controlled release This paper size applies Chinese national standard (CNS M4 specification (210X297 mm) -203-Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs 4 2 6 6 6 3; at ___B7 V. Description of the invention ( 2〇1) Among the active ingredients, when the eye or other external tissues (such as mouth or skin) are infected, it is better to use a topical ointment or cream, which contains, for example, 0.075 to 20% w / w of active ingredients (the content of active ingredients is 0.1% to 20%, and is a progressive increase of 0.1% w / w, such as 0.6% w / w * 0.7% w / w, etc.) , Preferably 0.2 to 15% w / w, most preferably 0.5 to 10% w / w »When formulated into an ointment, this active ingredient can be used in combination with paraffin or water to soften the incubating matrix. In addition, this active ingredient can also be used Formulated into a cream with an oil-in-water cream base. If desired, the aqueous phase of the cream base may contain, for example, at least 30% w / w polyol Alcohols (ie, alcohols with two or more hydroxyl groups), for example, propylene glycol, butane-1,3-diol, mannitol, sorbitol, glycerol and polyethylene glycol (including PEG 400), and mixtures thereof. Topical Formulations preferably contain compounds that enhance absorption or penetration of the active ingredient through the skin or other damaged areas. Examples of such transdermal penetration enhancers include dimethylimine and related analogues. The oily phase of the emulsion of the present invention may be It is composed in a known manner with known ingredients. When only emulsifiers are included in this phase, it is preferred to include a mixture of at least one emulsifier and a fat or oil (or both a fat and an oil). Preferably, a hydrophilic emulsifier It is used in combination with a lipophilic emulsifier (as a stabilizing agent), preferably both oil and fat. Emulsifiers (with or without stabilizers) make up the so-called emulsifying 蠘 'and 蠘 and oil and fat make up the so-called emulsifying. Soft and cautious matrix, which forms an oily dispersed phase of the cream. The paper size it / species of family standards (CNS) Λ4 specification (21GX297 calendar) '-204-(Please read the precautions on the back before reading this article ^ ¾ Page)

* 1T \ 4 2 66 6 3 Λ: Five 'Description of the Invention (202) Emulsifiers and emulsion stabilizers suitable for the formulation of the present invention include Tween®69, Span®80, cetylstearyl alcohol, benzyl alcohol, myristyl alcohol , Glycerol monostearate and sodium lauryl sulfate. The oil or fat to which this formula is applied is selected depending on the desired cosmetic properties * The cream is preferably a non-greasy, non-staining and washable product that has appropriate uniformity and does not leak out of the tube or other container . Available are linear or branched, monovalent or divalent alkyl esters, such as diisocaproate, isocetyl stearate, propylene glycol diesters of coconut fatty acid, isopropyl myristate, decyl oleic acid Ester, isopropyl palmitate, butyl stearate, blend of 2-ethylhexyl palmitate or branched ester (such as Crodamol CAP), the latter three are better esters β as required Nature, which can be used alone or in combination. Alternatively, high melting point fats such as white soft paraffin and / or liquid paraffin or other mineral oils can be used. Formulas suitable for topical use in the eye also include eye drops, in which the active ingredient is dissolved or suspended in a suitable carrier, especially its aqueous solvent. The concentration of the active ingredient is preferably 0.5 to 20% w / 5%。 w, more preferably 0.5 to 10%, most preferably 1.5%. Formulas suitable for topical use in the mouth include: lozenges Printed by the Bayer Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs * The active ingredients are contained in a flavoring base, usually sugar cane, acacia and tragacanth; oral Pasti 1 les, which contain the active ingredient in an inert matrix, such as gelatin and glycerin, or sucrose and gum arabic; and mouthwash * which contains the active ingredient in a suitable liquid carrier. Rectal formulations can be in the form of suppositories | suitable bases for mixing include, for example, cocoa butter or salicylate. The lung or nasal formula has a particle size of, for example, 0.1 to 1 scale of this paper, which is applicable to the Chinese National Standard (CNS) A4 specification (ϋ297 mm) ~ ~ 426663 Λ V. Description of the invention (203) 50 0 microns (Including the increasing combination of particle diameters in the range of 0 1 to 500 micrometers 1 such as »0 5 X, 30 micrometers &gt; 3 5 micrometers, etc.), which are quickly inhaled through the nasal passage or through the mouth Alveolar formulation suitable for use including aqueous or oily solutions of active ingredients 0 Formulas suitable for use in aerosol or dry powder formulations can be made according to conventional methods * Also eta and other medical agents (such as previously used to treat or prevent epidemics Cold A or B infection. Compounds) are applied together. 0 The vaginal formula can be a uterine condom 9 sanitary pad 9 cream 9 gel t paste 9 tincture or spray composition form 9 which contains active ingredients in addition to the technique. Known to be an appropriate vehicle 0 parenteral Formulations include aqueous and non-aqueous sterilization injections * which may contain antioxidant buffer substances and bacteriostatic substances, as well as a solute aqueous non-aqueous sterilization suspension which makes the blood of the formulae isotonic. It may contain suspension agents and thickening These formulations are presented in unit-dose or multiple-dose containers, for example, sealed ampoules and vials f and can be stored under lyophilization, and only need to be added with a sterile liquid carrier 9 before use, such as' Note. Water for injection 0 Temporary The injections and suspensions used are made from sterilized narrative powders> granules or tablets. The preferred unit dose formulation is a dosage or sub-dosage unit (as described above) or an appropriate portion of its activity. Ingredient α should be understood 9 In addition to the ingredients specified above »The composition of the invention may contain other agents conventionally used in such a composition» Example If &gt; □ The composition can contain a flavoring agent. 0 The present invention also proposes a veterinary composition * which includes at least '~~ 1 of the above-mentioned activities. Please read the precautions on the back page. This paper applies Chinese national standards (CNS) Α4 specifications (2 丨 0 X 297 mm) -206 — V. Description of the invention (204) A7 B7 Printed by the Central Laboratories of the Ministry of Economic Affairs, the Shellfish Consumer Cooperatives, and veterinary vehicles. Veterinary carriers are substances which are used to apply the composition &apos; can be solid, liquid or gaseous, are inert or veterinary acceptable, and are compatible with the active ingredient. These veterinary compositions can be applied orally * parenterally or by other desired routes. The compound of the present invention can also be used to provide a controlled release pharmaceutical composition containing one or more compounds of the present invention as an active ingredient, wherein the release of the active ingredient is controlled and adjusted without frequent medication, or the active ingredient is improved Pharmacokinetic or toxic profile (profile) ° The effective dose of the active ingredient depends at least on the nature of the condition to be treated, toxicity, for the prevention (lower dose) or for the treatment of influenza infection, method of administration 01, and the pharmaceutical composition used, which can be determined by a physician based on customary dose modification studies. ♦ The expected dose is about 0.01 to 100 mg / kg body weight / day, preferably about 0.01 to 10 mg / day. kg body weight / day, more preferably, about 0.01 to 5 mg / kg body weight / day, and most preferably about 0.05 to 0.5 mg / kg body weight / day. "For example, an adult weighing 70 kg should be inhaled. When used in a manner, the daily dose is 1 mg to 100 Orng, preferably 5 mg to 50 mg, and can be taken in a single or multiple doses. The active ingredient of the present invention may be used in combination with other active ingredients. The combination is determined by the condition to be treated, the cross-activity between the ingredients, and the pharmacological properties of the combination. For example, when used to treat viral infections of the respiratory system, especially influenza, the composition of the present invention can be used with antiviral agents (eg, gecidine ((Please read the precautions on the back before filling in s'. ^-Page ). Packing. The size of the L paper is applicable to the Chinese National Standard (CNS) Λ4 specification (210X297 mm) -207-Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs 4 2 6 6 6 3: a? ______B7 V. Description of the invention ( 205) amantidine) * Rimantine and ribavirin) are used in combination. Generally, antibiotics, antipyretics and analgesics are administered with compounds of the invention. Metabolites of the compounds of the present invention The in vivo metabolites of the compounds of the present invention are also within the scope of the present invention, provided that this product is novel and non-obvious to the prior art. This product can be obtained from the application of the compound | for example, oxidation, reduction * hydrolysis, amidation * esterification, etc., mainly due to the enzymatic process. Therefore, the present invention includes novel and non-obvious compounds prepared by a method of contacting the compound of the present invention with mammals for a period of time to produce its metabolites. Typically, a radiolabeled compound (such as C1 4 or H3) is first prepared, and a measurable dose (eg, usually greater than about 0.5 mg / kg) of the compound is administered parenterally to an animal (such as , Rat, mouse, guinea pig, monkey or human), after a time sufficient for metabolism to occur (typically about 30 seconds to 30 hours, isolated from urine, blood or other biological samples) These products are easily isolated because they are labeled (others are isolated using antibodies that bind to the remaining epitopes in the metabolites) * The structure of the metabolites is customary For example, MS or NMR analysis is used to determine the analysis of metabolites. Usually, the analysis of metabolites is studied in a way known in the art for drug metabolism. This transformation product is not found elsewhere in the body, even if it does not have neuraminidase inhibition Activity, can also be used for diagnostic analysis during the treatment of compounds in this case. This paper size applies Chinese national standards ((: &gt; ^ &gt; six 4 specifications (21〇 '/ 29 &quot; 7 male))--208----- ------ install-3 (please Note on the back of the reading and fill in this page) Order 426663 A7 B7 ___ V. Description of the invention (206) Other uses of the compound of the invention The compound of the invention, or a biologically active substance that is hydrolyzed or metabolized by the body can be used as an immunogen Or conjugated with a protein, that is, as an ingredient of an immunogenic composition, made as an antibody that can specifically bind to the protein, the compound or its metabolite, the aforementioned metabolite still retains the immunogenicly recognized epistereoisomers (Antibody binding site). Therefore, this immunogenic composition can be used as an intermediate in the preparation of the antibody (for diagnosis of the compound or its novel metabolite * quality control method, etc.). This compound is used to improve the antibody against other The ability of non-immunogenic polypeptides. At this time, these compounds act as haptenic sites and can stimulate an immune response that interacts with unmodified conjugated proteins. Preferred hydrolysates include the aforementioned protected Product of hydrolysis of acidic and basic groups. As mentioned above, acidic or basic ammonium (e.g., albumin *) containing immunogenic polypeptides Hemocyanin (fixed to the keyhole) is usually used as an immunogen. The above metabolites can retain a substantial degree of cross-activity with the compounds of the present invention. Therefore, the antibodies of the present invention can bind to unprotected compounds of the present invention without Binding to a protected compound; in addition, in the presence of a metabolite, the antibody may bind to the protected compound and / or metabolite without binding to the protected compound, or may specifically bind to one or all of them Binding * This antibody is not expected to interact with natural substances. Substantial cross-reactivity refers to the reactivity obtained for a particular analyte (which is sufficient to interfere with the results of the analysis) under specific analytical conditions. The immunogen of the invention includes Stereoisomers of Compound 1 of the invention are bound to an immunogenic substance. In this article, this combination indicates that the ^ Zhang scale is applicable to the Chinese National Standard (howling) six 4 specifications (2 [0 parent 297 mm) '' '---------- install-(Please read first Note on the back, please fill in this page again) Ordering line 'Central Ministry of Economic Affairs 嫖 ♦ 扃 Printed by the employee consumer cooperative 4 2 6 6 6 3 ^-A7 B7 V. Description of the invention (207) Covalent combination to form immunogenicity The conjugate (where appropriate) is either a mixture of non-covalently bound substances, or a combination thereof. Immunogenic substances include auxiliary substances, such as Freund auxiliary substances, immunogenic proteins, such as viruses, bacteria, yeast, plant and animal peptides, especially hemocyanin * serum globulin fixed in keyholes, fetal bovine thyroid globules Protein or soybean trypsin inhibitor with immunogenic peptides. Typically, a compound having the desired epistereomeric structure is covalently conjugated to a immunogenic polypeptide or polysaccharide via a polyfunctional (usually difunctional) cross-linking agent * to prepare a hapten immunogen The method is known in the art, and any method previously used for conjugating haptens to immunogenic polypeptides, etc. is also applicable here, considering functional groups on the precursors or hydrolysates (which can be used for cross-linking) and production Possibility of an antibody specific for this anisotropy (as opposed to an immunogenic substance). Typically, the polypeptide is conjugated to a compound of the invention far from the stereoisomer used to identify it. This conjugate is made by conventional methods. For example, cross-linking agents such as

N —Hydroxysuccinimide, succinic anhydride or alkyl group -N = CN-(#Please read the notes on the back and then fill in page kr-l), 17 Cooperate with the staff of the Central Standards Bureau of the Ministry of Economy "Preparing a conjugate of the invention" This conjugate comprises a compound of the invention,

It is a one-knot or Ci — C

(Better, C 1 -C 2 5 and more preferably c 1- c 1 (&gt;) binding group is connected to the immunogenic substance. This conjugate is separated from the starting material and by-products by chromatography and other methods , And then sterilized and filtered, stored in bottles. The compounds of the present invention are cross-linked with the following groups, for example, vi hydroxyl, Eα carboxyl, Ui, Ex, Gi or Ti carbon atoms (substituted H); amine groups. Such compounds Peptide amines are also included, among which the name is 11 Shiben} {ϊ y-* 1 / η Μ 公 / y -210-A7 B7 4 2 66 6 3 5. Description of the invention (208) Make R or Reb as above. Animals are typically immune to this immunogenic conjugate or derivative, as well as antisera or monoclonal antibodies made conventionally. The compounds of the invention can be used to maintain glycoproteins in recombinant cell cultures Structural integrity, that is, it is added to enzymes made from glycoproteins to inhibit the neuraminidase-catalyzed cleavage of this desired glycoprotein. This is particularly useful for recombinant protein synthesis in heterologous host cells because This cell hydrolyzes the carbohydrate portion of the synthesized protein. The compound is polyfunctional. It can be used as a special kind of monomer in polymer synthesis. By way of example and not limitation, polymers made from the compounds of the present invention include polyamides and polyesters. The consumer cooperative prints the compound of the present invention as a monomer to make a polymer with a unique hanging functional group, which can be used in a homopolymer or a copolymer with a monomer other than the present invention. The homopolymer formed by the compound of the present invention The purpose of the material is: as a cation exchanger (polyester or polyamide) in the preparation of molecular sieves (polyamines), fabrics, fibers, membranes, molded articles, etc., in which the acid functional group is £ 1 and 1) 1 hydroxyl Therefore, the hanging basic Gi can be combined with the acidic functional group, for example, the acidic functional group in the polypeptide to be purified. Polyamines are formed by the association of Eι and GjS, and Ui and adjacent parts on the ring can be freely used as hydrophilic or hydrophobic groups (depending on the selected Ui). The method for making polymers from the compounds of the present invention is so skilled * The compounds of the present invention can also be used as a unique class of multifunctional surfactants. Especially when U α does not contain hydrophilic substituents, and is, for example, the size of alkyl paper is applicable to China National Standard (CNS) A4 specification (210X297 mm): '-211-426663 A7 B7 Staff Consumption of Central Standards Bureau, Ministry of Economic Affairs Cooperative printed 5. Description of the invention (209) or alkoxy, this compound has the properties of a bifunctional surfactant, which is useful for the following properties: interfacial activity, surface coating, emulsion modification, rheological modification Wetting properties with surface · The compound of the present invention can be used as a phase transfer agent when it has a specific structure with both polar and non-polar parts. By way of example and not limitation, the compounds of the present invention can be used in phase transfer catalysts and liquid / liquid ion extraction (LIX). The compounds of the present invention can optionally contain asymmetric carbon atoms in Ui, El, 61 and T1. As synergists in the synthesis or analysis of active substances * For example, a racemic mixture of carboxylic acids can be resolved into its mirror stereoisomers by the following method: 1) and the compound of the present invention (where Uz is an asymmetric hydroxyalkane or amine Ii) forming a mixture of non-mirromeric stereoisomeric esters or amidines; 2) isolating the non-mirromeric stereoisomers; 3) hydrolyzing the ester structure. Racemic alcohols are separated by using acid groups to form esters. In addition, this method can also be used to resolve the compounds of the present invention, even using the optically active acid or alcohol (in this case, it is a non-racemic starting material). The compounds of the present invention can be used as linkers or spacers in the preparation of affinity-absorbing parent materials for use in process-controlled immobilized enzymes or immunoassay reagents. The compound here contains a plurality of functional groups as positions for crosslinking the intended substance. For example • It is customary to bind affinity reagents such as hormones, peptides, antibodies, drugs, etc. to an insoluble matrix. The resulting insoluble reagent is used in the preparation, the analysis sample or other impure mixture absorbs the binding partner of the affinity reagent. Similarly, immobilized enzymes are used to perform catalytic conversions, and can easily recover enzymes. * When preparing analytical reagents, difunctional (please read the notes on the back ^ a ^ item first ... then install this page) * π This paper Standards apply to China's National Standards (CNS) Λ4 specification (210X297 mm) 212 426663 A7 B7 Printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs 5. Description of the invention (210) Compounds are usually used to bond analytes to detectable Many functional groups on the compounds of the present invention can be used for crosslinking. For example, the carboxylic acid or phosphonic acid group of El can form an ester or amine with the alcohol or amine of the reagent to be crosslinked, respectively. Β is suitable for OH, NHRi, SH, and azide (if necessary, it can be reduced before crosslinking) Into the amino position), CN, NO2, amino, guanidino, halogen, etc. In order to prevent the difunctional compound of the present invention from polymerizing when reacting with a crosslinking agent, the reactive group may be appropriately protected. Usually the compound of the present case is bonded to a hydroxyl group or an amine group on the first bonding partner via a carboxylic acid or a phosphonic acid group, and then covalently bonded to another binding partner as 1'1 or 01. For example, a first binding partner (eg, a steroid hormone) is esterified with a carboxylic acid of a compound of the present invention, and then this conjugate is crosslinked with a Gi hydroxyl group to activate Sepaharose (agarose trade name) with a brominated atmosphere. Steroids. Other conjugate chemistry are known. References, for example, '^ 112711 ^ -Immunoassay' (CRC, 1988, pages 71-135) and references cited herein "As mentioned above, the medically useful compounds of the present invention, of which 1 or 01 hydroxyl, carboxyl or amine The groups are protected and can be made into oral or sustained release dosage forms. In these applications, protection is based on removal from the body (eg, hydrolysis or oxidation) to form free carboxyl, amine or hydroxyl groups. Ester or amidine suitable for this purpose depends on the substrate specificity of the esterase and / or carboxypeptidase, which enzyme is expected to be found in cells where precursor hydrolysis is performed. If the specificity of this enzyme is unknown, the compounds of the invention can be screened until the desired substrate specificity is found. This is known from the appearance or antiviral activity of the free compound. The following two principles are generally used to select the amidine or ester of the compound of the present invention: (i) Please read the note on the back and then bird J. Binding on this page) The paper size is applicable to the Chinese National Standard (CNS) A4 specification (21 〇X 297 Mm) -213-i 4 2 6 6 6 3 A7 B7 V. Description of the invention (2 丨 1) In the upper gastrointestinal tract is not hydrolyzable or slowly hydrolyzed, (ii) the gastrointestinal tract and cell permeability, (iii) in Hydrolysable in the cytoplasm and / or systemic circulation. In screening analysis, it is better to use cells from specific tissues (such as those who are susceptible to influenza infection), such as the lung and bronchial mucosa. This technique is known in the art and can be used to determine bioavailability in the body, including intestinal stability, cell permeability Liver homogenate stability and plasma stability analysis. However, even if esters, amidines or other protected derivatives are not converted into free carboxyl groups in the body, amines or hydroxyl groups are still useful chemical intermediates. Exemplary methods for making the compounds of the present invention. The present invention also relates to methods for making the compositions of the present invention, which are made using any suitable technique for organic synthesis. Many of these techniques are known and many are detailed in: Compendium of Organic Synthetic Methods' (John Wiley &amp; Sons, New York), Vol. 1,

Ian T. Harrison and Shuyen Harrison, 19 71; Vo1 2, Ina T. Harrison and Shuyen Harrison, 1 9 74; Vo1. 3,

Louis S. Hegedus and Leroy fade, 1 9 7 7; Vo 1. 4,

Leroy G. Wade, j r., 1 9 8 0; Vo 1. 5, Leroy G. Wade,

Jr., 1984; and Vol. 6, Michael B. Sra i t h; and Ma r c h, J., ^ Advanced Organic Chemistry, Third Ed i t i ο n ^, (John Wiley &amp; Sons, New York, 1985), '

Comprehensive Organic Synthesis. Selectivity, Strategy &amp; Efficiency in Modern Organic Chemistry. In 9 Volumes ^, Barry H. Trost, Editor-in-Chief (Please read the notes on the back before you &#; this page)

+ δ · Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economy 4 2 6 6 6 3 ^. A7 ______ ^ B7___ V. Description of the Invention (212)

Pergamon Press, New York, 1 993 printing) ° Exemplary methods for preparing the compositions of the present invention are set forth below, and are intended to exemplify the nature of these manufacturing methods, not to limit them. In general, the reaction conditions (e.g., temperature, reaction time, solvents, isolation purification steps, etc.) for a particular reaction are well known in the art, and the references (including those cited therein) include detailed descriptions of these conditions. Typically, the temperature is between 100 ° C and 200 ° C, the solvent is aprotic or proton, and the reaction time is 10 seconds to 10 days. Isolation purification mainly consists of the following steps: interrupt any unreacted reagents Then, it is distributed in the water / organic layer system (extraction) to separate the product-containing layer. The oxidation and reduction reactions are typically operated at near room temperature (about 20 ° C). However, when metal hydrides are reduced, the temperature is usually reduced to 0 ° C to -1 0 o ° c. Most of the solvents are non-reactive during the reduction. Protonic, and can be protonic or aprotic when oxidized. Adjust the reaction time to achieve the desired conversion. Printed by the Central Standards Bureau of the Ministry of Economic Affairs, Shellfish Consumer Cooperative, the condensation reaction is usually at a temperature close to room temperature, but it is non-equilibrium, and it can usually be used at low temperature (0 ° C to -10: 00 ° C) when the condensation is controlled by power. The solvent can be protic (often an equilibrium reaction) or aprotic (often a kinetic control reaction). Standard synthetic techniques such as azeotropic distillation of reaction by-products and the use of anhydrous reaction conditions (eg, inert gas environment) are well known in the art and can be used when applicable. One of the exemplary methods for preparing the compounds of the present invention is as follows The reaction β shown in Fig. 1 is described in detail in the following 1 Experiment 'paragraph. This paper size applies to China National Standard (CNS) Α4 size (210X297 Gongcheng) 215 426663 A7 B7

V. Description of the invention (213)... Turn to Figure 1

0,

C02CH3

co2ch3 HO '0,

Qr N3 3 2

4

H3C

Η3 2CH ο C

H3C

up 2CH ο Printed by the Consumer Cooperatives of the Central Bureau of Standards, Ministry of Economic Affairs 6

H3C

Η 2 ο 8 This paper size applies to China National Standards (CNS &gt; A4 size (210X 297mm) -216-A7 B7 426663 5. V. Description of the invention (2 丨 4) The improvement of Figure 1 is reflected to form another specific Examples are shown in Reaction Diagrams 2-4. Reaction Diagram 2

Sc ^^ ° / Y ^ r-C 02Me AcHN '

CN 9 (Please read the precautions on the back before ^ it hurts this page.)

'NH 〇2M e

AcHN person / h2n &quot; ^ nh &lt; = i ^ 0 / -r ^ r-C OpM e AcHN, 2 11 Printed by the Consumer Cooperatives of the Central Standards Bureau, Ministry of Economic Affairs

AcHN Into ^ NBoc

BocHN ^ NH 12 This paper size is applicable to Chinese National Standard (CNS) A4 specification (2 丨 〇297mm) -217-4 2 6 6 6 3 A7 B7 V. Description of the invention (215) Reaction diagram 2 According to U tim 〇t 〇 With his colleague, AT etrahedr ο n Le e 11:. *, 31: 6379 (1990), aziridine 5 was converted to amine 9 by catalytic addition of TMSCN with Yb (CN) 3. The conversion of nitrile 9 to the corresponding methyl fat 10 series is completed using a standard three-step procedure: i) H2S &gt; ii) C Η 3 I. Iii) NHA c * in 'J. Med. Chem, 36: 1 8 1 1 ( 1 9 93) can be found in a typical transformation. Eye 9 was reduced to the amine methyl compound 11 by the method described in 'Modern Synthetic Reactions' 2nd ed. H.O. Honse, Benjamin / Cummings Publishing Co., 1 9 7 2. Carbamate compound 1 1 is converted into N, N &lt; -dione B 0c-1H-ϋ 比 ϋ-1-residual methyl fat (according to the method described in 'Tetrahedron Lett ·' 36: 299 (1 995)) Dione B oc is protected by guanidyl compound 12. Please read the noticed items first, and then tj page the order. WT Industry Consumers #Cooperative Seal of the Central Standards Bureau of the Ministry of Economic Affairs 4266 6 3 A7 B7 V. Description of the Invention (216) Reaction Figure 3

AcHN; C 〇2 M e AcHN 'NC C〇2tBu 13 14 ---------- install-(please read the precautions on the back before 顼 l this page)

AcHN z 15 NH〇

AcHN 17

C02Me 'Ύ nh2

NH Order &lt; ^^ ° '· 02M e AcHN' 16

BocN. ^ NH Ύ NHBoc &quot; · This paper printed by the Consumer Cooperatives of the Central Bureau of Standards of the Ministry of Economic Affairs is again in compliance with the Chinese National Standard (CMS) A4 (210X297 mm) 219 4 2 6 6 6 3 ^ A7 _____B7_ 5 2. Description of the invention (217) Reaction Figure 3 Aziridine 5 is opened with α-cyanoacetic acid third butyl ring to obtain 13. For this type of aziridine ring-opening reaction, please refer to '&quot; Tetrahedron Lett ,, 23: 5 0 2 1 [1 9 82) »under acidic conditions to selectively hydrolyze the third butyl ester, and then remove the carboxyl group to obtain出 Nitrile 14. Reduction of 14 to amine ethyl derivative 15 is completed as conversion from 9 to 11. Then the amine 15 was converted to guanidyl derivatives by the method described in N, N &gt; —Dione Bo c — 1H — Shamir—1 —Jun Jia Fat Yi, Tetrahedron Lett ', 36: 299 (1 9 9 5).物 1 6. Nitrile 1 4 is converted into the corresponding nail fat 1 7 through the above 9 to 10 conversion steps «(Please read the precautions on the back before continuing on this page) Ruler I sheet of paper suitable for quasi-standard bidder A7 B7 426663 V. Description of the invention (21S) Figure 4 Ha &lt; ./^ r-C02Me PGO „^ -C02Me PG〇v ^^ c〇2Me 〇 、

0, HO,: ςτ &lt; 19 n3 20 PGO &quot;

C02Me

PGO- AcHN

C02Me n3 21 22 (Please read the notes on the back before filling this page)

AcHN,

AcN (^ r n3 C02Me Order Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs 23 24

C02Me 27 This paper size is in accordance with Chinese National Standard (CNS) A4 (210X297 mm) -221-4 266 6 3 A7 B7 Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs Oxyhydrin 1 protection (PG = protecting group), for example, MO MC J2. Typical conditions can be found in Protective Groups in Organic Synthesis ^ 2nd ed., TW Greene, and PGM Wuts, John Wiley &amp; Sons, New York, NY, 1991 ° Epoxide 19 is ring-opened to N-N3 / NH4Ci? To form an amino alcohol by the procedure of Sharpless and his colleague 'J. Org. Chem, 50: 1557 (1985) 2 * Reducing 2 0 The formation of N-ethenyl aziridine is achieved in the following three steps: 1) MsC / triethylamine; 2) H2 / Pd; 3) A c C J 2 / B ratio is steep. Such transformations can be referred to 'Angew. Chera. Int. Ed. Engl.', 33: 5 9 9 (1 9 94) ° aziridine 2 1 at 6 5 ° C in Na N3 / NH 4 C i According to J. C he m. S oc · Perki η T ran s. I ', the ring-opening conversion into azidamine 2 2 as described in 80 1 (1 9 7 6). The MOM protection group of 2 2 was removed by the method described in Protective Gronp in. Organic Synthesis * 2nd ed., T.W. Greene and P.G_M.ffuts, John Wiley &amp; Sons, New York, NY, 1991. The resulting alcohol was directly converted to aziridine 2 4 β in Ts C 5 in pyridine. Such conversion can refer to 'Angew. Chem. Int. Ed. Engl /, 33: 599 (1994) e and then let aziridine 2 4 React with ROH, RNH2, RSH or organometallic (metal-R) respectively to get the corresponding ring-opening derivatives 2 5, 26, 27 and 27.1 · For ring opening of such aziridines, please refer to &quot; k. Note

Page I The size of this paper applies to the Chinese National Standard (CNS) A4 specification (210X297 mm) A7 B7 ^ 426663 V. Description of the invention (220)

Tetrahedron Lett /, 23: 502 1 (1 982) and ^ Angew. Chem .Int. Ed. Engl. ^, 33: 599 (1994) «Reaction Figure 5 Another class of compounds of the present invention are shown in Reaction Figures 5 a and 5 b Method. The cinnamic acid was converted to 2 8 by the method of S h i n g. T. K. M et al. Methanesulfonylation with MsCJ? In TEA / gives 29, which is reacted with NaN3 in DMF to get 30 »30, and 3 1 in CH2Cj? 2 * with TFA, which is found in TEA / CH2Cj22 &amp; M s C Triphenyl methylation yields 3 2 »Reaction with triphenylphosphine in water yields 33, which in sequence: 1) CH3C (0) Ci / pyridine: 2) NaN3 / DMF; and 3) NaH / Treated in THF to convert to 35. It is known in this art that various nucleophiles are alkylated 3 5 to obtain 3 6. The method of converting a compound such as 36 to other specific examples of the invention is as described above. This paper size applies Chinese National Standard (CNS) A4 (210X297 mm) -223-4266 6 3, V. Description of the invention (221) A7 B7 Reaction Figure 5a

Crotonic acid

0 、 ： α co2ch3 0H 28

C02CH3

n3 30 Please read the memorandum of the memorandum and fill in the page again. HO ^. / ^ v-C02CH3 • 〇 N3 31 'Line: gc

MsO / &lt; .. C02C H3 MsO '

N Printed by the Consumer Standards Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs n3 32

H 33 The paper size is applicable to the national standard (CNS) A4 specification (21 ο X 297 mm) -224-4 2 6 6 6 3, V. Description of the invention (222) A7 B7 Reaction Figure 5b

h-nC ^ jT co2ch3 n3 34

co2ch3 Please read the memorandum items on the back first

co2ch3

36

stT

H3C ΟΛ

3 Η c

H3C 1

02H Printed by the Consumer Standards Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs 37 38 This paper size applies to the Chinese National Standard (CNS) A4 (21 ο X 297 mm) 225 -225-426663 V. Description of the invention (223) Reaction Figure 6 A7 B7

co2ch3

co2ch3 ^ COoCHg N, n3 53 (Please read the notes on the back before filling in this page) i-

52

AcHN 54 N355

C02CH3 ix The consumer cooperation of the Central Bureau of Standards of the Ministry of Economic Affairs of the People's Republic of China. The printed paper size is applicable to the Chinese National Standard (CNS) A4 (210X297 mm) -226-4 266 6 3, a? Figure 6_ Another type of compound of the present invention is prepared by the method shown in Figure 6. Protected alcohol 2 2 (PG = methoxymethyl ether) in ^ Protective Groups in Organic Synthesis ^ 2nd ed., T.ff. Greene and PGM Wuts, John Wiley &amp; Sons, New York, NY, 1991 standard conditions Go on protection. Alcohol 51 is converted to acetate 52 with acetic anhydride and pyridine under standard conditions. Treatment of acetate 52 with TMSOT f or BF3. 0E 1: 2 gave oxazoline 53. Such transformations can be referred to 'Liebigs Ann. Chem. ^, 1 29 (1 99 1) and Carbohydrate Research &quot;, 181 (1993). In addition, the alcohol 51 can be converted into oxazoline 5 3 as follows: first converted to the corresponding mesylate or p-toluenesulfonate 23, and then converted to oxazoline under standard conditions, such as' J.〇rg Chem., 50: 1 1 26 (1 985) and Chem. Soc, 1 385 (1 970). The reaction of oxazoline 53 with ROH, RR ^ WH or RSH (where R and R — are in accordance with the definition of double 0 above) each results in corresponding ring-opening derivatives 54, 55 and 56. For such conversions, please refer to "J 〇rg.CHem, 49: 4889 (1 984) and 'Chera. Rev,', 71: 483 Du Yinzhu (1971). Reaction Schemes 7-3 5 Other exemplary methods for preparing compounds of the present invention are shown in Reaction Schemes 7-35 below. These methods are described in detail in the "Experiment" paragraph below. ((: Called the 8-4 specification (210/297 mm) -227-A7 B7 426663 Five. Description of the invention (225) Reaction Figure 7a OH HCk ^ \ L »C〇2H HO '

OH

o Golden acid

28 R ^ OH, R2 = H

»C02Me cr

OH

OH 63 (Please read the precautions on the back before making this page).

66 R = H 67 B-Piv Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs

PivCW. ^ V ^ c02Me

Cr r2o

68 R ·) = 1¾ = H 69 R- | + R2 = -S (0)-This paper size applies the Chinese National Standard (CNS) A4 specification (210X297 mm) -228-4 2 6 6 6 3 4: 5 Description of the invention (226) Reaction Figure 7b A7 B7

OOgMe

RCT

PivO «,, ^^ C02Me

N3 70 R = H 71 R = Ms

Piv〇 / ft .. ^^ C02MeXJ AcHN ^^ V 'n3

PivO ^. ^ \ ^ C〇2Me

73 &amp; 72

ho AcHN

R Printed by the Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs co2h 74 R = N3 75 R Two NH2 This paper size applies to China National Standard (CNS) A4 specifications (2 [0X 297 mm) -229-4 A7 B7 2 66 6 3 V. Description of the invention (227) Reaction Figure 7c

74

Ac〇 &quot; ,,. "'Y &quot;

AcHN ^ T

R 78 R = N3 79 R = NHg

AcHN

AcHN HO, &quot; .. ^^ C02CHPh2 xy n3 76

AcO / * „^^ \ ^ C〇2CHPh2

Xj n3 77

BocHN

C02CHPh2 AcHN n3

80 Printed by the Shellfish Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs 81 R = N3 82 R = NH2 This paper size applies to Chinese national standards (CNS &gt; A4 size (210X297 mm) -230-426663 A7 B7 V. Description of the invention (228 ) Reaction diagram 8 H3CO ~ ◦

H3CO 〜〇 AcHN

% srC02CH3 --------- ^ ------ ΐτ ------ Gland (Please read the precautions on the back before this page) Printed by the Consumers' Cooperative of the Central Bureau of Standards, Ministry of Economic Affairs

AcHN NH2 91 NH Λ BocHN NBoc 92

93 H〇 /, / ^ yC〇2HAcHN '^ V ^ NH __Λ Ϊ * TFA H2N ^ NH 94 Reaction Figure 9

co2ch3 6

AcHN ^^ h2102

c〇2h t03 The paper size is applicable to Chinese national standard (CNS &gt; A4 size UlOX297 mm) -231 426663 A7 B7 V. Description of the invention (229) Reaction chart 10 CH30 8 AcHN1

NH 2

114 115

Reaction diagram U

OH

cr.

C02Me

OH OH63

Order .J.L (please read the notes on the back before you read this page).

This paper size applies to the ten national standards (CNS) / U specifications (2 丨 0XM7 mm) -232-426663 A V. Description of the invention (23) Reaction Figure 12 A7 B7

130 131

Reaction Figure 13; I ..... pgo, ^^ co2ch3 AcHN ^ V 〇〇, C O2C H3 AcHN ^ V ^

Printed by the Consumers 'Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs I n3 N3 22 51 h3co &quot; ^ .co2ch3 h3co &quot; „, co2h AcHN ^ J i AcHN ^ n3 nh2 • HCI 150 151 Gutter 3' (Please read the precautions on the back before you 蓼^ This page) This paper size is applicable to China National Standard (CNS) A4 (210X297 mm) &gt; 1 426663 V. Description of the invention (231) Reaction Figure 14

AcHN ^^ Y ^ NH2 152 C02CH3

AcHN Hachiman NH2 153 This paper size applies to China National Standard (CNS) A4 (210X297mm) -234-4 2 6 6 6 3 Printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs

-235-426663 A7 B7 Employee Cooperative Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs

-236-426663 / V. Description of the Invention (234) Reaction Figure 17 A7 B7

Vj. C02H OH Shimonic acid

HO, HO

X

Ov

OH 180 CO2CH3

X cr

On: ..

OMs co2ch3 HOv ^^ C〇2CH3 HOv '&quot;' 130 OMs131 (Please read the precautions on the back first, and then VI this tile).

PGO „

〆 CO2CH3

O

PG = MOM 22 order

181

184. Printed by the Consumer Cooperatives of the Central Bureau of Standards of the Ministry of Economic Affairs

co2ch3 h3co-

co2CH3

This paper is applicable to the national standard (CNS) A4 (210X297 mm) -237-426663 A7 B7 V. Description of the invention (235) Reaction Figure 18

Ph3CN Ο co2ch3 n3183

co2ch3

co2h 191 reaction diagram 19

AcHN

C02CH3 NH 2

201 (Please read the precautions on the back before V &quot; this page) 200 Printed by the Staff Consumer Cooperative of the Central Bureau of Standards, Ministry of Economic Affairs

202

CO2H

AcHN

HN NH '* TFA

NH 203 '2 This paper size applies Chinese National Standard (CNS) A4 specification (210X297 mm) 238 4 2 6 6 6 3 A7 B7 V. Description of invention 丨 236) Reaction diagram 20 C 0 2 Η AcHN ^ T / ^ 〇 , '. ^% ^ C02Na AcHN ^ T ； nh2 h% h NH 丨 102 204 Reaction Figure 21 ： 0 丫 co2ch3 h2n ^ V ^ n3 205

co2h ---------- batch clothes ------ ΐτ ------, ^ ii / _3 (Please read the precautions on the back before shovelling &amp; this page) Standards for Indian policy of Shellfish Consumer Cooperative

co2h

co2h 208 This paper size applies Chinese National Standard (CNS) Λ4 specification (2 丨 OX 297 mm) 239-426663 A7 B7 V. Description of the invention (237) Reaction Figure 22

co2ch3 〇 -S ·

N h3c- ^ ηο Ν3209 / CO2CH3 0, C. 2 Η

HsC-S-H 'Ο210 NHc

(Please read the precautions on the back side before shoveling this page)-Binding 'Order Reaction Figure 23 h3c + K 〇 co2ch3

NH 2 H3c-rfi 〇

co2ch3 210 HN YA NBoc NHBoc212 Itchy

NHBoc 213 Η3〇 ~? H hn ^ nh〇 AH nh2214 The standard of this paper is applicable to Chinese National Standard (CNS) A4 specification (21 × 297mm) 240-426663 A7 B7 V. Description of the invention (238) Reaction Figure 24

C09CH 2 ^ '' 3

COoCH 2 ^ '' 3

co2ch3 216

co2h 217 (Please read the precautions on the back before ^ 34. 装. 寊) Reaction diagram 25. | /^^〇&quot;,.r^v&gt;C02CH3 AcHN ', NH2200

AcHN

C02CH3 HN ^ NBoc NBoc I 218 CH3

, AT line Printed by the Consumer Cooperatives of the Central Bureau of Standards of the Ministry of Economic Affairs

AcHN '219 HN ^ NBc. CH3

AcHN

This paper size is in accordance with China National Standard (CNS) 8-4 specifications (210X297 mm) -241-426663; A7 B7 Printed by the Employees' Cooperatives of the Central Bureau of Standards, Ministry of Economic Affairs

-ΟΛΟ _ 242 426663 A7 B7 Printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs

Page k. Read the notes on the back side binding) line 426663r 5. Description of the invention (241) Reaction diagram 30 A7 B7 〇 N3183

AcHN ’

NH '2 235 (Please read the precautions on the back before vk. This page) 装 _ 反 职 圆 21——

Cinchona acid Printed by Masonry Consumer Cooperative, Central Bureau of Standards, Ministry of Economic Affairs

0H

OTs C02Me 242

243

241

HO

,,,,. CO〇Me line

O The paper scale is applicable to the Chinese National Standard (CNS) A4 specification (210X 297 mm) 244 4 2 6 6 6 3: a? * B7 V. Description of the invention (242) Response chart printed by the staff consumer cooperative of the Central Standards Bureau of the Ministry of Economic Affairs Take one

200 1〇2 This paper size is applicable to China National Standard (CNS) A4 specification (210X297 mm) -245-426663 A7 B7 V. Description of the invention (Reaction Figure 33

co2ch3

228 250

(Please read the notes on the back before filling, ¼ page)-Pack. Order 228 251

-Line. Printed by the Consumer Cooperatives of the Central Bureau of Standards of the Ministry of Economic Affairs

NH «CFgCOaH 252 The size of this paper is applicable to the Chinese National Standard (CNS) A4 (2 [〇297mm) 2 Niu 5 —) 4 ^ 66 6 3 5. Description of the invention (243) Reaction Figure 34 A7 B7

c〇2ch3

co2ch2ch3

co2ch2ch3 262 reaction diagram 35

co2ch2ch3

263 I --------- 1 clothing ------ ΐτ ------ _ ')) (Please read the precautions on the back before knowing this page) Staff of Central Bureau of Standards, Ministry of Economic Affairs Printed by Consumer Cooperatives 262

264 This paper size is applicable to Chinese National Standard (CNS) A4 (210X297 mm) -246-426663 V. Description of the invention (244) A7 B7 H0 ,! Reaction Figure 36 6

ΟΗ co2h

Rst R51 cr

OH Shikimate 270 270

B

271 271

C

272 272

D Printed by the Consumer Cooperatives of the Central Bureau of Standards of the Ministry of Economic Affairs

This paper size applies Chinese National Standard (CNS) A4 specification (210X297 mm) -247-126663 V. Description of the invention (245) A7 B7 Reaction Figure 37

Crotonic acid

0H

0 274

F OH ΐ ^ COgRgi Ο V '·

OH 275 275

G

OH

276 Η HO 'Consumption Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs of the Consumer Consumption Co., Ltd. ▽ or 52272 This paper size is applicable to China National Standard (CNS) A4 (210X297 mm) 4266 6 3 y V. Description of the invention (with 6) 〇 //-| ^% pC02R51 * ', A7 B7 Ο

273 277 J ^ 53〇ν ^^-0〇2Π5 ·) n3 278 278

K RS3〇V / x ^ C02R51

279

H (Please read the notes on the back before this page). Binding and ordering 279 R53〇, ^^ C〇2R51h2n &quot; ^ V ^ n3 280

M

R 54% ^ co2r51 n3 281 The paper size applies to Chinese National Standard (CNS) Λ4 specification (2 丨 0X297 mm) 426663 A7 B7 V. Description of the invention (247) Reaction diagram 1 39 C02R51 ^ 54

N N3 281

C02R51 282 Ο

(Please read the precautions on the back, ^ k this page)-Pack '283

P

284 Order of the Consumer Standards Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs of India. The paper size is applicable to the Chinese National Standard (CMS) Λ4 specification (2 [0X 297 mm) -250-A7 B7 '426663 ^ 5. Description of the invention (248) Reaction Figure 40 ^ 56 ^ 55 '

'Ν' Η ΝΗ2

Q

283 nhr57 285 285

R

286 Printed by the Consumers' Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs. The paper size is applicable to the Chinese National Standard (CNS) A4 (21 0X 297 mm) -251-4 ^ 66 6 3 A7 B7 5. Description of the invention (2) Figure_40.1

S

288

T 288

289 υ

290

V Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs 291 This paper size applies to China National Standards (CNS) 8-4 specifications (2 丨 〇 X 297 mm)

Ε, ---------- xiang ------ ΐτ ------ a)} (Please read the precautions on the back before shoveling 1 page) -252 A7 426663 ^ p -V. Description of the invention (25) Another specific example of the preparation and use of the composition of the present invention is shown in the reaction diagrams 3 6-4 0-1. An object of the present invention is to include method 8 of the reaction diagram 36-40-1, 8'0'0 '£' 卩, 0'6'1 'j. K. L, M. N, 〇'P'Q' ' R'S'T'U, V or W (alone or combined) methods for preparing compounds of the invention. Table 2 7 illustrates specific examples of the methods A to W. Each specific example is an individual method using the unit method A_W (alone or combined). Table 2 7 The specific examples are separated by semicolons, ''. If the specific example is a single letter, it corresponds to one of the methods A to W. If there is more than one letter, it corresponds to each method and is performed in the order shown. Another object of the present invention is directed to a method for preparing compound 2 70 using shikimic acid (as shown in Reaction A of Figure 36), and a method for preparing compound 2 7 1 using compound 2 70 (as shown in Reaction Figure 36 B) ) 'Method for preparing compound 2 7 2 with compound 2 7 1 (as shown in reaction C of Figure 36), and method for preparing compound 2 7 3 with compound 2 7 2 (as shown in the reaction chart. Consumer Cooperative Printing (shown as D in 3 6), a method for preparing compound 2 7 4 with crotonic acid (as shown in Reaction Figure 37 E), and a method for preparing compound 275 with compound 2 7 4 (as in Method F shown in Reaction Figure 37), method for preparing Compound 2 7 6 using Compound 2 7 5 (as shown in Reaction Chart 37 G), method for preparing Compound 2 7 2 with Compound 2 7 6 (see Reaction Figure 37 (Shown in Figure VII), a method for preparing compound 277 using compound 273 (as shown in Reaction Scheme I of Figure 38), and a method for preparing compound 2 7 8 using Compound 2 7 7 (as shown in Reaction Scheme 38 J) The method for preparing compound 2 7 9 by using compound 2 7 8 (as shown in the reaction chart 3K), the paper scale is applicable to the Chinese national standard (CNS &gt; Λ4 specification (210X 297 mm) -253-4 2 6 6 6 3 A7 B7 Printed by Shellfish Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs 5. Description of the invention (251)), using compound 2 7 9 to make commission compound 2 The method of 80 (as shown in reaction chart L in Figure 38), the method of preparing compound 2 8 1 with compound 2 80 (shown in reaction chart 38M), and the method of preparing compound 2 8 2 with compound 281 ( As shown in N of Reaction Figure 3 9), a method for preparing compound 2 8 3 using compound 2 8 2 (as shown in Reaction Chart 3 9-10), and a method for preparing compound 2 8 4 using compound 2 8 3 (eg reaction The method of preparing compound 285 using compound 283 (shown as Q in reaction diagram 40) and the method of preparing compound 2 8 6 using compound 285 (shown in reaction diagram 40 R) The method for preparing compound 2 8 8 from compound 2 8 7 (shown as S in reaction diagram 40.1), the method for preparing compound 2 8 9 with compound 2 8 8 (shown as T in reaction diagram 40.1), using compound 289 The method for preparing compound 290 (shown as U in Reaction Figure 40.1), and the method for preparing compound 291 using compound 290 (such as As shown in V of Figure 40.1), the method for preparing compound 2 9 2 from compound 2 9 1 (as shown in W of Reaction Diagram 40.1). The general content of these exemplified methods is described below and in the examples. The following The products in the method are optionally isolated, isolated and / or purified before being used in the next method. The term "processing" refers to contacting, mixing, reacting, reacting, and other techniques commonly used to indicate that one or more chemical entities are processed into one or more additional chemical entities. So "treatment of compound 1 with compound 2" is synonymous with "make compound 1 and compound 2 react", "compound 1 and compound 2 contact", "compound 1 and compound 2 react" and other {please read the note on the back first ^ Item again ¥ ', 』This page is installed. Order-dance. The paper size is applicable to the Chinese National Standard (CNS) Α4 size (210 × 297 mm) -254-A / B7 426663 V. Description of the invention (252) General for organic synthesis It means that the compound 1 is "treated" or "reacted" with the compound 2. General method, 0 Μ, compared with 50 ° C · 100 ° C glass, plastic reaction argon) and so on. The conditions used in the treatment are based on the conditions and the "treatment" table that makes the organic chemical reaction reasonable and one unless otherwise specified. Normal concentration (0.01M to 1. Good 0.1M to 1M), temperature (1 100 ° C to 2 preferably -78 ° C to 150eC, more preferably -78 ° C to, most preferably 0eC to 100 ° C), reaction vessel (preferably glue, metal), solvent, pressure, Atmosphere (When insensitive to oxygen and water, it is preferably air, and the reaction sensitive to oxygen and water is nitrogen or knowledge of similar reactions known in organic synthesis techniques can be used to select conditions and devices. In particular, generally familiar with organic synthesis The artist chooses the known knowledge of this skill and expects to successfully perform the chemical reaction device. Method A, Reaction Figure 36 The compound 2 7 0 was prepared with shikimic acid in the following method * Central Standard of the Ministry of Economic Affairs 扃 Shun Yi 4 printed with shikimic acid The 5-diol can be used to selectively protect the two from the carboxylic acid group on carbon 1. Typically, the cis 4,5-diol is protected with a cyclic ketal, and the carboxylic acid group is protected with an ester. R5 is an acid-decomposable 1,2-diol protecting group, as cited above

Greene's work states that it is typically a cyclic ketal or acetal, more preferably a ketal of cyclohexanone or acetone. R31 is an acid-stable carboxylic acid protecting group, as explained in the works of Gereene cited above, which is typically a linear, branched or cyclic Ci ~ C12 alkyl, alkenyl or alkynyl, that is, a basic paper as shown in Table 2. Applicable to China National Standard (CNS). Λ4 now (210X297 mm) -255-4 2 6 6 6 3 a7 __ '_._ B7__ V. Description of the invention (253) 圑 2-7, 9-10, 15 or 100 — 66 0, more preferably a linear or branched Cl-C8 alkyl group, as shown in Table 2 2-5, 9 or 10 0 — 358, preferably a linear or branched Ci-Ce alkyl group, as shown in Table 2 The groups shown are 2-5 »9 or 100-141, but more preferably RS1 is methyl, ethyl, n-propyl, isopropyl, n-butyl, second butyl, isobutyl, or third Butyl "reacts shikimic acid to protect its carboxylic acid by R51, cis-4, and diol by R5. protection. Typically, shikimic acid is treated with an alcohol (eg, methanol, ethanol, n-propanol, or isopropanol) and an acid catalyst (eg, an inorganic acid or a sulfonic acid, such as methanesulfonic acid, benzenesulfonic acid, or toluenesulfonic acid). , Followed by ketal or aldehyde dialkyl ketal Λ acetal protection, such as 2,2-dimethoxypropane or 1,1-dimethoxy-cyclohexane, and the corresponding ketone or aldehyde (such as Acetone or cyclohexanone) is sometimes present. Optionally, prior to the dialkyl ketal or ketal treatment, the alcohol is separated from the acid catalyst treated product * separated and / or purified. Another method is to treat shikimic acid with CH2N2. Printed by the Shell Standard Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economics. Typically, this method involves treating shikimic acid with an alkanol or sulfonic acid, followed by a _dialkoxyalkane or pan-dialkoxycycloalkane with an alkane or The cycloalkanone was treated to give compound 2 70. More typically, this method includes treating shikimic acid with alkanol and sulfonic acid; residues cannot be obtained with excess alkanol; treatment with pyr-dialkoxyalkane or pyr-dialkoxycycloalkane and alkane or cycloalkanone This residue was used to form compound 2 70. More typically, this includes treating shikimic acid with methanol and p-toluenesulfonic acid; distilling off excess methanol to obtain a residue, and treating the residue with 2,2-dimethoxypropane and acetone to form compound 2 7 0 » Examples are exemplified by Examples 35. The M's scale is applicable to the Chinese National Standard (CNS) Λ4 specification (210 × 297 mm) -256-426663 A7 B7 V. Description of the invention (254) Method B, reaction diagram 3 6 ---------- : ¾—. Please read the precautions on the back before preparing the compound 2 7 0 with compound 2 7 0 on this page to activate the hydroxyl group at position 3, which is typically active for the displacement reaction. 'More typically * for position 4 The substitution of alcohol to form an epoxy ring is active. 0 is an alcohol-activating group. Typically, the substitution-activating group is replaced, and more typically, the position 4 alcohol is substituted to form the activating group of the epoxy ring reaction. Such groups include those typically used in the art, such as sulfonate, more preferably mesylate, benzenesulfonate, or tosylate. In a specific example, R52 merges with 0 (ie, -0R52) is a leaving group commonly used in this technique. Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economics Typically, this method involves treating compound 270 with halides to produce compound 271. More typically, this method includes treating compound 2 70 with sulfonium chloride in a suitable solvent to form compound 2 71. More typically, this method involves the treatment of compound 2 70 with sulfonium chloride in the presence of a suitable solvent, such as an amine, and a co-solvent (eg, haloalkane) to form compound 2 71. Preferably, this method comprises treating compound 2 70 with methanesulfonium chloride in triethylamine / dichloromethane to form compound 2 71. A specific example of this method is shown in Example 56 below. Method C »Reaction Figure 3 6 Compound 2 7 1 Compound 2 7 2 is prepared in the following manner» The acid-decomposable protecting group (r5.) At the hydroxyl groups at positions 4 and 5 is removed ^ Rs is typically removed. The alkali-decomposable carboxylic acid protecting group is not removed when the paper is removed (for example, the paper size applies the Chinese National Standard (CNS) Λ4 specification (210X297 mm) -257-A7 B7 4266 6 3 V. Description of the invention (257) Metal alkoxide (Such as sodium, potassium, lithium alkoxide). More typically, the compound 2 7 4 is treated with Na OMe in Me 0H to form the compound 2 7 5. A specific example of this method is shown below in Example 1 2 Method G, Reaction Figure 3 7 Compound 2 7 5 is prepared as compound 2 7 6 by activating the hydroxyl group at position 3, typically active for a displacement reaction, and more typically, formed by displacement of an alcohol at position 4 The reaction of the epoxy ring is reactive. R S2 is an alcohol-activating group. Typically, the substitution is reversed. The substitution of the position 4 alcohol to form an epoxy ring reaction includes those typically used in this technique, such as sulfonate * sulphonate, or Tosylate. In a specific example, an OR 52) is a leaving group commonly used for this technique. Typically, this method involves treating compound 2 7 6 with cavities. More typically • This method involves treating compound 2 7 5 with sulfonium chloride to form compound 2 This method involves treating compound 2 276 with sulfonyl chloride in the presence of a suitable solvent, such as an amine, as a haloalkane). Preferably, this method involves treating the compound 2 7 5 with pyridine / disulfosulfonyl chloride to form a compound. Specific examples of this method are shown in Example 10 below. The paper size applies the Chinese National Standard (CNS) Λ4 (210X297 mm) Notes for reading the back page should be printed by the Central Standards Bureau of the Ministry of Economic Affairs, Shellfish Consumer Cooperatives, which should print the activation base, which is more typical. Such groups are preferably mesylate, benzene, R 52 combined with 〇 (composition 2 7.5 to form in a suitable solvent with sulfo 76. More typically, and co-solvents (such as * 7 5 to form The compound chloromethane is represented by p-toluene 2 7 6 3. 3. A7 B7 4266 6 3: Fifth, description of the invention (258) Method Η · Reaction Figure 3 7 Compound 2 7 6 is prepared as the compound 2 7 2 by the following method. The hydroxy group at position 1 is removed to remove the protective group of cis-4,5-diol. The hydroxy group at position 1 is removed to form an olefinic bond between positions 1 and 6, and the cis-4,5-diol protective group is removed. The cis-4,5-diol is then regenerated. Typically, this method involves treating compound 276 with a suitable dehydrating agent, such as an inorganic acid (HC or H2S04) or S02C)? * More typically, the compound is treated as so2c J2 2 treatment, followed by alkanol treatment, and optionally in the presence of an acid catalyst. More typically, compound 2 7 6 is treated with S 02C in a suitable polar aprotic solvent (eg, amine) to form an olefin; An alcohol (as described above) and an acid catalyst (as described above) treat the olefin to form compound 2 7 2. More typically, let Compound 2 7 6 in pyridine / CH2CJ? 2, a temperature of 100 ° C to 0 ° &lt;: (preferably -100 1 to -10 ° £ :, most preferably -78. £ :) Treated with S 02C J? 2 to form olefins; treated with methanol and p-toluenesulfonic acid to form compounds 2 7 2 »A specific example of this method is shown in Example 10 4 below. The reaction method is shown in Figure 3. 8 Compound 2 7 3 is prepared as compound 2 7 7 by the following method. The hydroxyl group at position 5 is protected. Typically, the protecting group is an acid-decomposable hydroxyl protecting group. More typically, the protecting group is not It will be transferred to the adjacent hydroxyl group. R 53 is an acid-decomposable hydroxyl protecting group. As mentioned in Greene, the private paper size applies the Chinese National Standard (CNS) Λ4 specification (210X 297 mm) -261-Central Ministry of Economic Affairs Printed by the Consumer Cooperatives of the Standards Bureau 4 2 6 6 6 3 A7 __B7_ V. Inventor (259). More typically, r53 is an acid that can cut off ether, preferably R53 is methoxymethyl '(MOM' CH3— 0—CH2). Typically, this method involves treating with a hydroxyl protecting group reagent (as described by Greene). Compound 2 7 3 »More typically, this method involves placing Compound 2 7 3 in a suitable solvent (eg, a polar aprotic solvent) with a substituted or unsubstituted haloalkane or alkene (eg, methoxymethyl chloride ( MOM chlorine, CH3 — 0 — C H2C). More typically, this method involves treating compound 2 7 3 with MOM chlorine in an amine solvent. More typically, this method involves treating compound 2 7 3 with MOM chlorine in diisopropylethylamine. A specific example of this method is shown in Example 5 9 below. Method J, reaction diagram 3 8 Compound 2 7 7 is prepared as compound 2 7 8 in the following manner »The epoxy group at positions 3 and 4 is ring-opened to form an azide. More typically * Ring-opening of the epoxy group at positions 3, 4 forms a 3-azido-4-hydroxy compound 2 7 8. Typically, this method involves treating the compound 2 7 7 with an azide salt in a suitable solvent. More typically, this method involves treating compound 2 7 7 with a sodium azide and a mild base (such as ammonium halide) in a polar protic solvent (such as alkanol or water). More typically, this method involves treating compound 2 7 7 with sodium azide and ammonium chloride in a water / methanol solution to form compound 2 7 8. A specific example of this method is shown in Example 60 below. Method K, reaction diagram 3 8 This paper size applies Chinese National Standard (CNS) Λ4 specification (210X297) while I ~ -------- ^-3 (Please read the precautions on the back before # ' -^. This page)

, 1T -262-Α7 B7 4 266 6 ο, 5. Description of the invention (26〇) Compound 2 7 8 is prepared as compound 2.79 by the following method. The hydroxy group at the 4 position of the compound 2 7 8 is substituted with a 3-azido group to form the compound 2 7 9. Typically, this method involves treating compound 2 7 8 with a hydroxy activating group (as described above), an organic phosphine, and a phosphonium. More typically, this method includes treating compound 2 7 8 with a sulfonium halide (as described above) to form an activated hydroxy compound, and then treating the activated trialkyl compound with a trialkylphosphine or triarylphosphine (eg, triphenylphosphine). To form a scaly salt, and then treated with amidine (eg, amine) to form compound 2 7 9. More typically, this method includes treating compound 2 7 8 with trityl chloride to form an activated hydroxy compound, treating with triphenylphosphine to form an iron salt, and treating the phosphonium salt with triethylamine and water to form compound 2 7 9 * A specific example of this method is shown in Example 61 below. Method L, Reaction Diagram 3 8 Compound 2 7 9 is made into compound 2 8 0 »Aziridine Compound 2 7 9 opens with azide to form azide 2 8 0 Central Ministry of Economic Affairs Co-op printing Typically this method involves treating compound 2 7 9 with an azide salt in a suitable solvent. More typically, this method involves treating compound 279 in a polar aprotic solvent (eg, ether, amine, amidine) with sodium azide and mild age (eg, halogenated amine). • More typically, this method includes Compound 2 7 9 was treated with sodium azide in DMF to prepare compound 2 8 0. A specific example of this method is shown in Example 63 below. This paper size applies to China National Standards (CNS) Λ4 specifications (} 10X297 mm). The consumer cooperation of the Central Tihua Bureau of the Ministry of Economic Affairs Du printed 4 2 6 6 6 3 ^ A7 B7 V. Description of the invention (261) Method M Figure 3 8 Compound 2 8 0 is prepared as compound 2 8 1 by the following method. The protected hydroxyl group at the 5 position is replaced with the amine at the position 4 to form aziridine 281. Typically, aziridine 281 is substituted with an acid-decomposable group, more preferably with an aziridine activating group. R54 is an acid-decomposable group, typically an acid-decomposable amine protecting group (as described by Greene above), more typically, R 54 is an aziridine activating group, and more preferably, it can activate aziridine for acid catalysis Ring-opening group. Typically, R includes, by way of example and not limitation, linear or branched: Ci—Ci2—one-keto-alkane-1—group, in which the alkyl moiety is Ci— «: ^ linear or branched alkyl (eg, CH3 (CH2) ZC (0) —, z is an integer from 0 to 10, that is, acetate (CH3C (0) —), etc.), substituted methyl (eg, trityl (Ph3C-) * or shorthand T r), or a urethane, such as BOC or Cbz, or a sulfonate (eg, an alkane sulfonate (eg, a mesylate)). More typically, R 54 includes a trityl group and a Ci-Ce 1-keto-alkane- 1-yl group, more preferably one having 1,2,3,4,5,6 carbon atoms, and most preferably Those with 2 or 3 carbon atoms. Typically, this method involves treating compound 280 with a deprotecting agent to remove R53, R54 generating agents (such as those described by Greene * R54-halides, such as acetyl chloride or Tr-Ci ?, or 1134-0- R54, such as acetic anhydride) and hydroxyl activating group (such as method B, the reaction described in Figure 36). More typically, this method includes treating compound 2 0 0 with a polar protic solvent, and performing any 'in the presence of the above-mentioned acid catalyst to form a first intermediate. The paper size is applicable to Chinese national standard (CNS &gt; Λ4 specification (210 X 297 mm) (Please read the notes on the back before filling in. SV-this page)

4 266 6 3 Λ Α7 __Β7_ V. Description of the invention (262); Treat the first intermediate with T r — C $ in a polar aprotic solvent (for example, amine) to form a second intermediate; and then polar aprotic The second intermediate is treated with a sulfonium halide (eg, methanesulfonyl chloride or p-toluenesulfonyl chloride) in a solvent (eg, amine) to make compound 2 8 1 • More typically • this method includes methanol and HC j? Treat compound 2 8 0 to form a first intermediate, which is treated with Tr-C and triethylamine to form a second intermediate, which is treated with methanesulfonyl chloride and triethylamine to make compound 2 8 1 »This method Specific examples are shown as Example 6 4 below. Method N, Reaction Figure 3 9 Compound 2 8 1 is prepared as compound 2 8 2 by the following method. After the ring opening of aziridine 2 91, the resulting amines are substituted with R 55 to form compound 2 8 2. Typically, aziridine 2 8 1 is ring-opened by an acid-catalyzed ring-opening reaction, and the resulting amine is tritiated. For the above W3 », typically, R55 is -C. (0) R5. More typically, Rss is a C (O) Ri, and more preferably R55 is C (0) c Η 3. Printed by the Shellfish Consumer Cooperative of the Central Government Bureau of the Ministry of Economic Affairs

W R5e is as described above. Typically, R5e is We-0 — S —, or 3 — N (H) —. More typically, ruler 53 is 115-0 — 'Rs—S — or Rs—N (H) —, better, Rse is Rs_〇—, and most preferably R5e is Ri— 0 — β. Typically, this method includes Let compound 2 8 1 be treated with an acid catalyst and a compound of formula We_Xi—Η (where xda is defined) to form an amine intermediate; it is represented by formula W3-X: —W3, Wa-Xi. The size of the compound processing paper is applicable to the Chinese National Standard (CNS) A4 (210 X 297 mm) -265-4 2 6 6 6 3 A7 B7 V. Explanation of the invention (263) (where X l. Is the leaving group) ) To form compound 2 8 2. Acid catalysts are preferably Lewis acids commonly used for this technique, such as BF 3 m Ε t 2 0, T i C 1 3 * T Μ S 0 Τ f S m I 2 (τ Η F) 2, L i C 1 0 4, MS (c 1 0 4) 2 * L n (0 Τ f) 3 where L η = Y b, G d, N d) 9 T i (0 i P r) 4, A 1 C 1 3 TA 1 B r 3 'Β e C 1 2, C d C 1 a * Z η C 1 2 * Β F 3' BC 1 3 »Β B r 3 &gt; G a C 1 3 y G a Β r 3, Τ ic 1 4 * Τ i B r 4 * Z r C 1 4, S η C 1 4, S η B r Λ ysb C 1 s * S b Cl 3 * B i C 1 3 »F e C 1 3, υ C 1 4, * S c C 1 3 * YC 1 3 L ac 1 3, C e C Is, P rc 1 3, N d C 1 3 1 S m C 1 3 * Εu C 1 3 * G d C 1 3 * T b C 1 3, L u C 1 3 * D y C 1 3 * Η 0 C 1 3 * E r C 1 3, T m C 1 3 * Υ bc 1 3 1 Zn n I ζ » A 1 (0 P r 1) 3 JA 1 (a C ac) 3 Z η Β Γ 2 9 or Sn C 1 4. Typically i-0-&gt;-S y or-Ν (H)-. X 1. It is typically a factor, such as »c 9., B r or I. More typically, — this method involves printing B F3 · E t 02 with compound 5 of compound R 8 — 0 Η 9 R 5 —SH or R 5 — Ν H 2 and printing it with the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs. 1 forms an intermediate, which is treated with alkanoic anhydride to form compound 2 8 2. More typically, 'this method involves treating compound 2 8 1 with an R5-OH compound and BF3 · E t20 to form an intermediate' and treating this intermediate with substituted or unsubstituted acetic anhydride to form compound 2 8 2. Examples of R5-0H compounds include 2_7, 9 — 10, 15 and 660 in Table 2 (where Qig — this paper size applies to Chinese national standards (CNS &gt; Λ4 specification (210X297 mm) I ------- -i-- (Please read the precautions on the back and then on this page) Order) -f -266-_____B7 V. Description of the invention (264) 0H), other examples are shown in Table 2 5 below (including Its CAS registration number) and those shown in Table 26 (including its CAS registration number and Aldrich Chemical Company product number). Examples of more typical 2R5-0H compounds are those described in Tables 2-5, 9 and 100-1 4 1 (where 0 is an OH). Method N. In another specific example shown in Figure 3-9, R55 is Η. Typically, this method includes treating compound 2 8 1 with an acid catalyst and R5e-X-hydrazone compound (wherein 2 is as defined above) to form an amine intermediate to form compound 2 8 2 * The acid catalyst and Xi are as defined above. More typically, this method includes treating compound 2 8 1 with R5—OH, Rs—S 11 or Chi 5—NH2 compound and B F3 · E t 20 to form compound 2 8 2 »More typically, this method includes treating The 5-OH compound and BF3 · E t20 treat the compound 2 8 1 to form the compound 2 9 2 r5 — 0h, such as those described above. Specific examples of this method are given below as examples 6 5, 8, 6, 9 2 and 9 5 »

The Central Laboratories of the Ministry of Economic Affairs, Consumer Affairs Cooperative, printed method I, reaction Figure 3 9 Compound 2 8 2 was made into compound 2 3 by the following method. Azide 292 is reduced to amine compound 283 »Typically, this method includes treating compound 2 8 2 with a reducing agent to form compound 2 8 3. More typically, this method involves treating compound 2 8 2 with hydrogen and a catalyst (such as a Pt / C, or Lindlar catalyst) or a reducing agent (such as the trialkylphosphine or triarylphosphine described above). More typically, 'This paper size applies to Chinese National Standards (CNS) A4 specifications (210X2mm) _ 267-Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs 4266 6 3 at _ * B7 V. Description of the invention (265 ). The method includes treating compound 2 8 2 with triphenylphosphine in water / THF to form compound 2 8 3. Specific examples of this method are shown in Examples 8 7, 9, 3, and 96 below. Method P, Reaction Figure 3 9 Compound 2 8 3 is prepared as compound 2 8 4 by the following method. The acid protecting group was removed. Typically, this method involves treating compound 2 8 3 with a base. More typically, this method involves treating the compound 2 3 3 with a metal hydroxide in a suitable solvent, such as an aprotic polar solvent. More typically, this method involves treating compound 2 8 3 with THF in potassium hydroxide to prepare compound 2 8 4. Specific examples of this method are the following Examples 8 8, 9 4 and 9 7. Method 0, Reaction Scheme 40 Compound 2 8 3 is made into compound 2 8 5 * by the following method. The amine is converted to protected guanidine. R 57 is a guanidine protecting group commonly used in this technology, such as B C or Me »Typically, this method involves treating compound 2 3 3 with a guanidating agent (such a person skilled in the art). Examples of guanidating agents include di-BOC thioureaminimine methanesulfonic acid (Kin et al .: Tet. Lett. 〃 29 (26): 3183-3186 (1988) and 1-guanidylpyrazole ( Bernatowicz et al .; 'Tet. Lett. ^ 34 (2 1): 3389-33 9 1 (1 993) · More typically, this method involves treating compound 2 8 3 with di-BOC thiouric acid. More typical This paper size applies to China National Standard (CNS) Λ4 specification (2I0X297 mm) gutter. '(Please read the precautions on the back #' € 4r this page) -268-A7 B7 426663 V. Description of the invention ( 266) type, this method includes treating compound 2 8 3 with di_B 0 C thioureic acid and Hg C to form compound 2 8 5. A specific example of this method is shown below as Example 6 7 * Method R, Reaction Figure 40 Compound 2 8 5 is prepared as compound 2 8 6. The carboxylic acid protecting group and guanidine protecting group are removed. Typically, this method includes treating compound 2 8 5 with a base, followed by acid treatment as described above. More typically This method includes treating compound 2 8 5 with a metal hydroxide base (as described above) to form an intermediate, and then treating to compound 2 8 6 with acid. More typically This compound includes the potassium hydroxide aqueous solution and THF treated compound 2 8 5 to form an intermediate, and then the intermediate is treated with TFA to form compound 2 8 6. Method S, reaction diagram 4 0.1 Compound 2 8 7 is prepared by the following method Compound 2 8 8. Compounds 28 7 and 288 printed by the Consumer Cooperatives of the Ministry of Economic Affairs of the Central Standard Bureau are printed as "11 and 5 2" as described above. Typically, ι is a C02R5i (as described above), and ^ is ^ 1, F or methyl, more preferably Η * Typically, J 1 is Η or linear or branched Ci-Ce alkyl, more preferably Η, methyl, ethyl, n-propyl or isopropyl, more preferably Η «

Re0 and Rel are groups which can react to form Compound 2 8 8 and replace the aziridine ring with Re3 (defined below). Typically, Re. One of Rei is primary or secondary amine, or the basic paper size that can be converted into primary or secondary amine is applicable to China National Standard (CNS) A4 (210X29? Mm) -269-A7 B7 d26663 V. Description of the invention (267) 圑. R 6. These groups with R include, by way of example and not limitation, -N Η 2 &gt;-N (H) (Reb), —N (Reb) 2, —N Η (R!), — N (Ri) (Reb) and -N3 «Reo and r61 The other is preferably a group that can be replaced by a primary or secondary amine to form aziridine, including, by way of example and not limitation, -OH, -0Rea, B r, CJ ? With I.? Typically, Re. It is in a trans configuration with the ruler. More typically, R β. It is a primary or secondary amine, or a group that can be converted into a primary or secondary amine. The ruler 61 is a group that can be replaced by a primary or secondary amine to form aziridine. More preferably, Re0 is a jS-azide Or Shi-NH2, Rei is — 0Η, α — 0 -methanesulfonyl, or α_0 —p-toluenesulfonyl ”is described in the following method U, the reaction shown in Figure 40.1. This method includes treating compound 2 8 7 to form compound 2 8 8. It is typically made by treating compound 2 8 7 with Re. Completed by replacing Rel. More typically, compound 2 8 7 is treated to activate Rei, making it R β. Replacement. More typically, treating compound 2 8 7 activates ruler 81 to be Re. Permutation, and ruler 6. It will be activated to replace Relo. If Re. Both Rei and Rei are activated, so they can be activated simultaneously or sequentially. If performed sequentially, it can be performed in any order. Typically, Rei is activated at 116. After activation. Make R 61 versus R β. The replacement activation is performed as follows. Compound 2 8 7 is treated with a hydroxy activator such as methanesulfonyl chloride or tosylsulfonium chloride. The activation of Re0 to the replacement Rei is accomplished by treating compound 2 8 7 to form a primary or secondary amine, and then treating the amine with hydrazone. As an example and not a limitation, the reductive azide is used as a reducing agent for amines and osmium-treated compounds 2 8 7 This paper size applies Chinese National Standard (CNS) Λ4 specification (210X 297 mm) Order β (Please read the back Note: Please fill in this page again.) Printed by Shellfish Consumer Cooperative, Central Standards Bureau, Ministry of Economic Affairs -270-A7 B7 426663 V. Description of Invention (268) A specific example of this method is to use compound 2 8 7 with Rei activator and Re . The activator is treated to become compound 2 8 8. In another specific example, compound 2 8 7 is R 61 activator, R β. The activator and alkali treatment gave compound 2 8 8. In another specific example, compound 2 8 7 is treated with R β i activator, R β 〇 activator, and base to form compound 288 in a suitable solvent. In another specific example, compound 287 (where R β0 is an azide) is treated with a Re α activator and an azide reducing agent to prepare compound 288. In another specific example, compound 2 8 7 (where R β〇 is an azide) is treated with Ra a activator, azide reducing agent and alkali in a suitable solvent to prepare compound 2 8 8 * In a specific example, compound 2 8 7 (where Re. Is an azide and Rel is a hydroxyl group) is treated with a hydroxyl activator and an azide reducing agent to compound 2 8 8. In another specific example, compound 2 8 7 (where Reo is an azide and Rel is a hydroxyl group) is treated in a suitable solvent with a hydroxyl activator and an azide reducing agent to obtain compound 2 8 8 ^ In another specific example Compound 2 8 7 (wherein R β. Is an azide and R 01 is a hydroxyl group) is treated with a hydroxyl activator 'azide reducing agent and a base to obtain compound 2 8 8. In another specific example, the compound 2 8 7 (where Re 0 is an azide and a hydroxyl group) is treated in a suitable solvent with a hydroxyl activator, an azide reducing agent, and an alkali to form a compound 2 8 8. A specific example of this method is shown in the above method κ, and the reaction is shown in Figure 38. Method T, reaction 40. 1_ Compound 2 8 8 is prepared into compound 2 8 9 by the following method. This paper size is applicable to Chinese national standard (CMS &gt; Α4 size (210 × 29? Public). Please read the notes of Ⅰ & Zaiji., 1st, Binding Printed by the Central Laboratories of the Ministry of Economic Affairs, Consumer Cooperatives -271-426663 ,:-Central Laboratories of the Ministry of Economic Affairs, Consumer Affairs Cooperatives Du Yinzhuang 5. Description of Invention (269) R β &lt; The type is Η * Reb or a group that can be converted into Η or Ret .. More typically 9 R β 4 is Η 〇R 6 5 is typically G i or a group convertible to G i, preferably R θ 5 is one N 3 »one -CN or 'one (CR, R 2) m, W 2» preferably R β «r is -N 3 &gt;--N Η 2, — N (H) (R β t,) 9 -N (R 6b) 2, -C Η 2 Ν 3 or -C Η 2 C Ν. Typically, compounds 2 8 8 are processed to amines 2 8 9 ο more typically, compounds 2 8 8 to Nucleophile (preferably a local nitrogen nucleophile, such as the cationic salt of R 6 S f R 6 5 »or the protonated congener of R 0 5 as examples and not limiting For example, N Η 3, azide salts (such as Na N 3, K Ν 3, etc.) HCN cyanide (such as Na CNKC Ν, etc.) or cyano salt (such as (C Η 2C Ν)), such as N a CH 2 C Ν KC Η 2 C Ν, etc.)). More typically, compounds 2 8 8 are treated with an azide salt. A base (preferably a mild base such as a halogenated amine) and a solvent (more It is preferably a polar aprotic solvent (such as t-ether, amine or amidine) 0 In the specific example, the compound 2 8 8 is treated with a nucleophile. In another specific example, the compound 2 8 8 is a suitable solvent In another specific example, compound 2 8 is treated with nucleophilic agent Cfej and tested to compound 2 8 9. In another specific example, compound 2 8 8 is treated with a 3fcB nucleophile and a base in a suitable solvent to form compound 2 8 9 Q. In another specific example, compound 2 8 8 is treated with a nitrogen nucleophile to form a compound 2 89. In another specific example, compound 2 8 8 is treated with a nitrogen nucleophile in a suitable solvent to form compound 2 8 9. In another specific ns. Example, 1 compound 2 8 8 is a compound that is treated with a nitrogen nucleophile and the remainder. The paper size applies to the Chinese National Standard (CNS) Λ4 specification (210X297 Gongjie) -272-4266 6

Q A7 B7 V. Description of the invention (27〇) 289. In another embodiment, compound 288 is treated in a suitable solvent with a nitrogen nucleophile and a base to form compound 290. In another specific example, compound 2 8 8 is treated with azide to compound 2 8 9. In another embodiment, compound 2 8 8 is treated with azide salt in a suitable solvent to form compound 2 8 9 β. In another embodiment, compound 2 8 8 is treated with azide salt and base to form compound 2 8 9. In another specific example, compound 2 8 is treated with an azide salt and a base in a suitable solvent to form compound 2 89. A specific example of this method is shown in Method L above, and the reaction is shown in Figure 38. Method U, reaction Figure 40. 1 Compound 2 8 9 was prepared as compound 2 9 0 in the following manner. R β2 is a compound that can react with an amine to form an aziridine ring substituted with Ree (as defined below) in Compound 2 90. Typically, b is a group that can be replaced with a primary or secondary amine to form aziridine. Such groups include, as examples, not

Limit, one 0 R Ο Η

OR

β AB r C il ---------- Equipment-(Please read the notice on the back first and then this page) Order> t Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economics Typically, Re2 and Nitrogen reaction configuration at position 4 is better, Re2 is 10R 53. Ruler 64 is 11 or RSb, and is typically an acid-decomposable protecting group, such as R54. Ree is H ′ Ret> or K · 54β This method involves treating compound 2 8 9 to form compound 2 9 0 &lt; • Typically, compound 2 8 9 is treated such that R a2 is replaced by an amine at position 4. More typically, the treatment of compound 2 8 9 activates the amine at position 4 to replace Re2. Better, the amine that handles the compound 2 8 9 activation position 4 applies the Chinese National Standard (CNS) A4 specification (2t〇X 297 mm) to the wood paper standard. -273-273 Printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs Λ2666 3 Λ Α7 B7 V. Description of the invention (271) The reaction of RS2, and Rez is activated and easily replaced by the amine at position 4. * If both R32 and amine at position 4 are activated, they can be activated simultaneously or sequentially. If performed sequentially, it can be performed in any order. Preferably, the activation of R β2 is after the activation of position 4 amine. The replacement activation of R β2 to position 4 amine is performed as follows, using a hydroxylation agent (such as method B, The reactions shown in Figure 36) are treated with compound 2 8 9. R β2 is optionally deprotected before activation. The position 4 amine pair replaces the Re2 activation system as follows. Treatment of compound 2 8 9 forms a primary or secondary amine, and then Treat the amine with an acid catalyst (as described in Method N, as shown in Figure 3-9). Typically, when Re2 is 10Ra3 and Ree is Rse ', this method includes treating compound 2 8 9 with R53, R 54 generating agent (as described by Greene, Rs &lt; t —halide, such as acetochlorine or Tr-CJ2, or R54-0-R54, such as acetic anhydride) and hydroxyl activating group (as described in Method B, reaction described in Figure 36). The compound 2 8 9 is treated with a polar protic solvent and optionally performed in the presence of the above acid catalyst to form a first intermediate: the first intermediate is treated with T r-C in a polar aprotic solvent (eg, amine) To form a second intermediate: treating the second intermediate with a sulfonium halide (eg, methanesulfonyl chloride or p-toluenesulfonyl chloride) in a polar aprotic solvent (eg, amine) to form compound 2 9 0. More typically, this method includes treating compound 2 8 9 with methanol and HC $ to form a first intermediate, which is treated with T r -C and triethylamine to form a second intermediate, which is treated with methanesulfonyl chloride Treated with triethylamine to make compound 2 0. This paper size is applicable to the national standard (CNS) Λ4 specification (210X297 cm) (Please read the precautions on the back before ^ &amp; this search) Order 'Travel. 4 266 6 A7 B7 V. Description of the invention (272) In a specific example, compound 2 8 9 is an acid catalyst It is synthesized into compound 2 0. In another embodiment, compound 2 8 9 is treated with an acidic catalyst in a suitable solvent to form compound 2 9 0. In another embodiment, compound 2 8 9 is a hydroxyl activator and an acid catalyst. Treated as compound 2 0. In another embodiment, compound 2 8 9 is treated with a hydroxyl activator and an acid catalyst in a suitable solvent to form compound 2 9 0. * In another embodiment, compound 2 8 9 is removed with a hydroxyl group. The protective agent, the hydroxyl activator and the acid catalyst are processed into the compound 290. In another specific example, compound 2 8 9 is treated with a hydroxyl deprotecting agent in a suitable solvent, and the hydroxyl activator and an acid catalyst are used to treat compound 2 9 0. Specific examples of this method are as described in Method M above, Reaction Figure 3 8 * Method V, Reaction Figure 4Γ &gt;. 1 Compound 2 90 is prepared as Compound 2 91 by the following method. Aziridine 290 is processed into compound 291. Typically, aziridine 2 9 0 is ring-opened by an acid-catalyzed ring-opening reaction, and the resulting amine is tritiated. Please read the precautions below and then Zhen Guang i%. Printing bags R β 8 are each Η

R 1 ^ or 1 ^ 55 (as above). Typically, R55 is preferably a C (0) RS4, one of 1168 is Η or Reb * and the other is W ^ ruler 87 is 1 ^ (as above). Typically, 1 ^ 7 is rated 8-0—, We—S —, or We-N (H) —, and more preferably Re7 is K · 5—0-, ruler 5-5— or 115 ~ ^ (Η) _. Typically, this method includes the use of an acid catalyst and We — Xi_ Η compound paper size applicable to Chinese National Standard (CNS) A4 specifications (210 × 297 mm) -275-A7 B7 426663 Five 'Invention (273) As defined above) the compound 290 is treated to form an amine intermediate; the intermediate is then treated with a Wa-Xi-Wa or W3-Xlt) compound (wherein 10 is a leaving group) to form a compound 2 91. We—Xi-X compounds and acid catalysts can be treated with W3_ Xi—W3 or W3-—Xϊ. The compounds are processed at the same time or before. The acid catalyst is typically method N, as shown in Figure 39. More typically, this method includes treating compound 2 9 0 with a compound of R5 — OH, Rs — SH, or 3-1 ^ 112 and an acid catalyst; and then treating with compound 911 to form compound 2 9 1. A specific example is the treatment of compound 290 with a We-Xi__ compound and an acid catalyst to form compound 291. Another specific example is treating compound 2 9 0 with a compound and an acid catalyst in a suitable solvent to prepare compound 2 9 1. Another specific example is the treatment of We-Xi-fluorene compound, acid catalyst and W3-Xi ~ W3 or W3-- 1 () compound 2 9 0 to make compound 2 9 1. Another specific example is a We ~ Xi- hydrazone compound, an acid catalyst, and W3— again in a suitable solvent: all ^ or Wa-Xi. Compound treatment of compound 2 9 ◦Compound 2 9 1 is prepared. A specific example of this method is the method N above, and the reaction is shown in FIG. Printed by the Central Standard of the Ministry of Economic Affairs, Coconut Consumer Cooperative, Method W, Reaction Figure 40.1 Compound 291 is made into compound 292 in the following way. Compound 2 9 1 is processed into compound 2 9 2. R05 is typically converted to G〆Ui—a specific example is Re7, a specific example is Ti—N (Rea) 2, as shown in method v above, as shown in Figure 4. The producer of this paper applies the standards of the ten countries. (CNS) Λ4 specification (2 丨 〇χ; 297 mm) 276 Printed by Shellfish Consumer Cooperative, Central Standards Bureau, Ministry of Economic Affairs 426663 Λ Α7 ___ Β7 V. Description of the invention (274) In a specific example, '1165 is deprotected, alkane Acetylation, guanidination, oxidation or reduction to Gi. Any of the above-mentioned processes may be performed in any order or simultaneously. By way of example and not limitation, when Re5 is an azide group, the specific method of this method includes methods 0, 0Q, OQR, and 0P. Typically, alkylating agents are commonly used in this art and include, by way of example and not limitation, alkyl halides (eg, methyl iodide, methyl bromide, ethyl iodide, ethyl bromide, n-propyl iodide ' N-propyl bromide, isopropyl iodide, isopropyl bromide) and dilute hydrocarbon oxides (eg, ethylene oxide, propylene oxide). The base catalyst described herein can be used arbitrarily in the alkylation step.-Specific examples include making compound 2 9 1 (where Re5 is an azide group) treated with a reducing agent to compound 29 2 »Another specific example includes making compound 29 1 (where Re5 is an azide group) is treated with a reducing agent in a suitable solvent to form compound 2 9 2. Another specific example includes treating compound 2 9 1 (where R es is an amine group) with an alkylating agent to compound 2 9 2. Another specific example includes treating Compound 2 9 1 (where Re5 is an amine group) in a suitable solvent with an alkylating agent to form Compound 2 9 2. Another specific example includes treating compound 2 9 1 (where Re5 is an azide group) with a reducing agent and an alkylating agent to form compound 2 9 2 »Another specific example includes allowing compound 2 9 1 (where Re5 is an azide group) ) Treated with a reducing agent and an alkylating agent in a suitable solvent to form compound 2 9 2. Another specific example includes treating compound 2 9 1 (where Re5 is an amine group) with an alkylating agent and a base to form compound 2 9 2. Another specific example includes treating compound 2 9 1 (where ROS is an amine group) in a suitable solvent with an alkylating agent and a base to form compound 2 9 2 »Another specific example includes making compound 2 9 1 (where R 85 is Mannyl group) Reducing agent, alkyl t-sheet scale is applicable to Chinese National Standard (CNS) Λ4 specification (2 丨 OX297 male 1 j ~ -277-(Please read the precautions on the back before the field ^ '-this page)

426663 ^ A7 B7 V. Description of the invention (275) The chemical agent and alkali catalyst are treated to form the compound 2 9 2. Another specific example includes treating compound 2 9 1 (where R β5 is an azide group) in a suitable solvent with a reducing agent, an alkylating agent, and a base catalyst to treat compound 2 9 2. Specific examples of this method are examples 6 8 and 69 below. Table 25-Exemplified compounds of formula R5-〇H (CAS No C 4 Fluorohydrin 13 7 0 Printed by Shellfish Consumer Cooperative, Central Standards Bureau, Ministry of Economic Affairs 0 (R *, R *) — (±) — 3-Fluoro-2 — Butanol (9755_61-6) 1-Fluoro-2 —butanol (124536 -12-5) (R) -3-Fluoro 1-butanol (120406 — 57 — 3 —Fluoro-1-butanol (19808 -95- 8) 4 -Fluoro-2 -butanol (18804 — 31-4) (R *, S *)-3-Fluoro-2 -butanol (6228 — 94) (R * * R *) -3 -Fluoro 2 -butanol (6133 -82) 2 -Fluoro 1 -butanol (4459-24-9) 2 -Fluoro-2 -methyl- 1-propanol (3 109 — 99 — 7 3 —Fluorine —2 — Butanol (1813 — 13- 4 4 —Fluoro-1-butanol (372 — 93 — 0) This paper size applies to China National Standard (CNS) Λ4 specification (210X 297 mm) I ----- ---------- 1T ------ Like !. I (Please read the notes on the back before filling in the page) -278 Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs 4 2 6 6 6 3 ”A7 ___B7_ _V. Description of the invention (276) 1-Fluoro-2-methyl-2-propanol (353 -80-0) C 5 Argon alcohol 2-fluoro-1-pentanol (123650-81- 7) (R) — 2 —fluoro_3 — methyl-1 1 Butanol (113943-11-6) (S)-2-fluoro-3-methyl-1 1-butanol (113942-98-6) 4-fluoro-3 -methyl- 1-butanol (1 0471 5 -2 5-5) 1-fluoro-3-pentanol (30390 — 84 — 2) 4-fluoro-2 —pentanol (19808 — 9 4 — 7) 5 —fluoro-2 —pentanol (18804 — 35 — 8) 3-fluoro-2-methyl-2-butanol (7284 — 96 — 0) 2-fluoro-2-methyl-1-butanol (445 6 -02 — 4) 3-fluoro-3- 3-methyl 1-butanol (1 98-77-2) 5-fluoro-1 1-pentanol (592-80-3) C 6-fluoroalcohol (R ~ (R *, S *))-2-fluoro- 3-Methyl- 1-pentanol (168749-88-0) This paper's size applies to Chinese National Standard (CNS) A4 (210X297 mm) -279-426663 A7 B7 Printed by the Staff Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs Description of the invention (277)! 1 1 —fluoro-2 &gt; 3 dimethyl-2 —butanol (1 6 1 0 8 2 1! — 9 0 — 2) 1 1 I 2 — fluorine — 2 3 — Dimethyl — 1 — butanol (1 6 1 0 8 2 choose 1 1 first 1 — 8 9 — 9) Read I Read 1 [(R) — 2 monofluoro-4 — methyl — 1 — pentanol (back 1 | 1 1 5 7 9 8 8 — 3 0 — 2) note 1 1 thing 1 (S — (R This, R *)) — 2 — fluoro — 3 — methyl — 1 — pentane 1 alcohol (1 5 1 7 1 7 — 1 8 — 9) write '^ this% page 1 (R this S *) — 2 — fluoro — 3 — methyl — 1 — pentanol (s._〆II 1 5 1 6 5 7 — 1 4 — 6) 1 1 1 (S) — 2 — gas — 3 3 — dimethyl — 1 —butanol (1 ί 1 4 1 0 2 2 — 9 4 — 8) IT 1 (Μ) — 2 — fluoro-2 — methyl — 1 — pentanol C 1 1 1 3 7 5 0 5 — 5 7 — 8) 1 1 (S) one 2 one gas one 1 --- hexanol (1 2 7 6 0 8 one 4 7 one 1 body 3) I 3 — fluorine — 3 — methyl — 1 — Pentanol (1 1 2 7 5 4 — 1 1 2 2 — 0) 1 I 3 — Gas — 2 — Methyl — 2 — ™ Pentanol (6 9 4 2 9-5 4 — 1 1 5) 1 i 2 — fluoro — 2 — methyl — 3 — pentanol (6 9 4 2 9 — 5 3 — [1 4) 1 I 1 monofluoro 3 —hexanol (3 0 3 9 0 — 8 5 — 3) 1 1 1 5 monofluoro-2 monomethyl — 2 — pentanol (2 1 8 7 1-7 8 — 1 1 This paper size applies to the national standard of China (CNS) A4 (210X297 mm) -280-426663 A7 B7 V. Description of the invention (278) 3) 5-Fluoro-3-Hexanol (19808-92-5) 4-Fluoro 3-Methyl 2- 2-pentanol (19808-90-3) 4-Fluoro-4 Monomethyl-2 -pentanol (19031 — 69 — 7) 1-fluoro-3, 3-dimethyl-2-butanol (4604 — 6 6-4) 2 —fluoro-1 2 —methyl-1 — Amyl alcohol (4456-03-5) 2-fluoro-4 4-methyl-1-pentanol (4455 — 95-2) 2-fluoro-1 —hexanol (1786 — 48 — 7) 3 — fluoro-2, 3 -dimethyl-2-butanol (661 -63 -2) 6- 1 1-hexanol (373 — 32-0) C7 Fluorohydrin 5 —Fluoro 5 —Methyl 1-Hexanol (1 68268 — 63 -1) (R ) — 1-Fluoro-2 —Methyl-2 —Hexanol (153683-63-7) (S)-3-Fluoro-1 -Heptanol (141716 — 56 — This paper size applies to Chinese National Standard (CNS) A4 Specification (2 丨 〇X297mm) -281-426663 A7 B7 Printed by the Consumers' Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs 5. Description of the invention (279) (S) — 2 monofluoro-2-methyl — 1 — hexanol ( 1 3 2 3 5 4 — 0 9 — 7) (R) — 3 — fluoro — 1 -heptanol (1 2 0 4 0 6 — 5 4 — 4) (S) 2 — fluoro — 1-heptanol ( 1 1 0 5 0 0-3 1 — 7) 1 — fluoro-3 — heptanol (3 0 3 9 0 — 8 6 — 4) 7 — fluoro — 2 — heptanol (1 8 8 0 4 — 3 8 — 1) 2 — ethyl — 2 — (fluoromethyl) — 1 — butanol (1 4 8 0 0 — 3 5 — 2) 2 — (fluoromethyl) — 2- — 1 — pentanol (1 3 6 7 4 — 8 0 — 1) 2 — m — 5 — methyl-1 monohexanol (4 4 5 5 — 9 7 — 4) 2 — fluoro — 1 — heptanol ( 1 7 8 6 — 4 9 — 8) 7 — fluoro — 1 — heptanol (4 0 8 — 1 6 — 2) C 8 fluoro alcohol (M) — 2 — gas — 2-methyl — 1 — heptanol ( 1 3 7 5 0 5 — 5 5 — 6) 6 monofluoro — 6 — methyl — 1 —heptanol (1 3 5 1 2 4 — 5 7 — 1) 1 — fluoro — 2 monooctanol (1 2 7 2 9 6 — 1 1 — 1) (R) — 2 — Fluoro 1-octanol (1 1 8 2 0 5 — 9 1 — This paper applies the national standard (CMS) A4 ^ (210X2 ^ 7) (Mm) -282-4 2 6 6 6 3 A7 * B7 Printed by the Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs. 5. Description of the invention (280) 7) (soil) — 2-gas one 2 — methyl — 1 — Heptanol (1 1 7 1 6 9 -4 0-1) (S) — 2-fluoro-1 — octanol ( 1 1 0 5 0 0 — 3 2 — 8 (S) — 1-fluoro-2 monooctanol (1 1 0 2 7 0 — 4 4 — 5) (R) — 1-fluoro-2 2-octanol (1 1 0 2 7 0-4 2 — 3) (taxi) — 1-fluoro-2 — octanol (1 1 0 2 2 9 — 7 0 — 4) 2 monofluoro — 4-methyl-3 — heptanol ( 8 7 7 7 7 — 4 1 — 1) 2 — fluoro — 6 — methyl — 1 — heptanol (4 4 5 5 — 9 9 — 6) 2 monofluoro — 1 — octanol (4 4 5 5 — 9 3 — 0) 8 — fluoro — 1-octanol (4 0 8-2 7 — 5) C 9 fluoroalcohol 6 — fluoro — 2, 6 — dimethyl — 2 monoheptanol (1 6 0 9 8 1 — 6 4 — 6) (S) — 3-fluoro — 1 — nonanol (1 6 0 7 0 6 — 2 4 — 1) (R 1 (R * R *)) — 3-fluoro — 2 — nonanol ( This paper size applies the Chinese National Standard (CNS) Λ4 now (210X297 mm) -283-4 266 6 3 Λ Printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs of the People's Republic of China 5.Invention (2S1) 1 3 7 9 0 9 1 4 6-7) (R — (R tk, s *)) — 3 monofluoro — 2 — nonanol ( 1 3 7 9 0 9 — 4 5-6) 3 monofluoro — 2 — nonanol (1 3 7 6 3 9 — 2 0 — 4) (S — (R He, R *)) — 3 — fluorine — 2 — Nonanol (1 3 7 6 3 9 — 1 9-1) (S — (R, R *)) — 3 — Fluoro — 2 — Nonanol (1 3 7 6 3 9 — 1 8-0) (Earth ) — 3 — Fluoro-1 — Nonanol (1 3 4 0 5 6 — 7 6 — 1) 2 — Fluoro — 1 — Nonanol (1 2 3 6 5 0 — 7 9 — 3) 2 — Fluoro — 2 — Methyl — 1 — octanol (1 2 0 4 0 0 — 8 9 — 7) (R) — 2 — fluoro-1 — nonanol c 1 1 8 2 4 3 — 1 8 — 8) (S) — 1 — Gas — 2 — nonanol (1 1 1 4 2 3 — 4 1 — 7) (S) — 2 — er (one 1 — nonanol (1 1 0 5 0 0 — 3 3 — 9 ) 1 — Fluoro-3 — Nonanol (3 0 3 9 0 — 8 7 — 5) 2 — Fluoro 2 6-Dimethyl — 3 — Heptanol (6 8 4 — 7 4 — 2) 9 — Fluoro 1 1 Monononyl alcohol (4 6 3 — 2 4 — 1) This paper size is applicable to the Chinese National Standard (CNS) A4 size (210X297 mm) (Please read the precautions on the back before going to this page)-Installation ·

, 1T 426663 / A7 B7 Printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs. 5. Description of the invention (282) C 1 0 Fluorohydrin 4 — Fluoro — 1 — Decanol (1 6 7 6 8 6 — 4 5 — 5) ( Ρ) — 1 0 — fluoro — 3 — decanol (1 4 5 4 3 8 — 9 1 — 1) (R — (R sol, R *)) — 3 — fluoro — 5 — methyl — 1 — nonanol (1 4 4 0 8 8 — 7 9 — 9) (Ρ) — 1 0 — fluoro — 2 — decanol (1 3 9 7 5 0 — 5 7-5) 1 — fluoro — 2 — decanol (1 3 0 8 7 6 — 2 2 — 1) (S) — 2 — fluorine — 1 — decanol (1 2 7 6 0 8 — 4 8 — 4) (R) — 1 — fluorine — 2 — decanol (1 1 9 1 0 5 — 1 6 — 7) (S) — 1 — fluoro — 2 — decanol (1 1 9 1 0 5 — 1 5 — 6) 2 — gas — 1 — decanol (1 1 0 5 0 0 — 3 5 — 1) 1 — fluoro — 5 — decanol (1 0 6 5 3 3 — 3 1 — 7) 4 — fluoro — 2 2 5 9 5 —tetramethyl — 3 —hexanol (2 4 2 1 2 — 8 7 — 1) 1 0 monofluoro 1 — decanol (3 3 4 — 6 4 — 5) C 1 1 fluoro alcohol 1 0 — gas — 2 — methyl — 1-decyl alcohol (1 3 9 7 5 0 — 5 3 — 1) Please read the note at the back. The paper size applies to the Chinese National Standard (CNS) A4 specification (210X297 mm).

I Binding gland-285-A7 B7 V. Description of the invention (283) 2 -fluoro-1-+-alkanol (1 10500-34-0) 8 -fluoro-5, 8-dimethyl-5 -nonanol ( 110318-9 0-6) 1 1-fluoro-2-undecanol (101803-63-8) I 1-fluoro-1-+ -alkanol (463-36-5) C 1 2 fluoroalcohol II- Fluoro-2-methyl-undecanol (139750 -52-0) 1 -Fluorododecanol (1 3 2 5 4 7 — 3 3 — 2) (R *, S *)-7 — Fluoro-6-dodecanol (130888-52-7) (R *, R *) — 7-Fluoro-6-dodecanol (130876-18-5) (S) —2-Fluoro-1 Dodecanol (127608 — printed by the Consumer Cooperatives of the Central Bureau of Standards, Ministry of Economic Affairs 4 9 — 5) 1 2 —fluoro-2 -pentyl ™ heptanol (1 20400-9 1- 1) (R *, S * )-(Earth) — 7-Fluoro-6-dodecanol (119174-39-9) (R *, R *) — (±) — 7-Fluoro-6-dodecyl alcohol (119174-38- 8) This paper size is in accordance with Chinese National Standard (CNS) Λ4 specification (210X297 mm) -288-4 2 66 6 3 A7 B7 V. Description of the invention (284) 2 -Fluoro-1-dodecanol (1 10500 -36 — 2) 11-fluoro-2 2-methyl-dodecanol ( 101803 -67-2) 1-fluoro-1dodecanol (100278-87-3) 1 2 -gas 1 -dodecanol (3 5 3-3 1-1) C 4nitro alcohol ( R)-4-nitro-1 -butanol (129520 — 34 9 S)-4 mononitro-2 -butanol (120293 — 74 5 4 -nitro-1 monobutanol ion (一 1) ( 83051 13-2) (R *, S *) -3 -nitro-2 -butanol (82978 — 0 2-7) (R *, S *)-3 -nitro-2 -butanol (82978- 0 1 — 6) Central Bureau of Standards, Ministry of Economic Affairs®; printed by the Industrial and Consumer Cooperatives 4 —Nitro-1 1-butanol (75694-90-5) (±) -4 —Nitro-1 2-butanol (72959- 86- 5 4 mononitro-2-butanol (55265 — 82-2), 1-acid mononitro-2 —butanol (22916 — 75-2 3-acid-nitro-2 —butanol (2 2 9 1 6 — 74-1 Each paper size applies the Chinese National Standard (CNS) A4 specification (210X297 mm) -287-4 2 6 6 6 3, A7 _ B7 V. Description of the invention (285).) 2 -Methyl-3 -nitro-1 monopropanol (2 1 5 27-52-6) 3 -nitro-1 -butanol (6270-16-2) 2 -methyl-1 1-nitro-2 —Propanol (544 7 — 9 8 — 3) 2 -acid mononitro 1-butanol (4 1 6 7 — 9 7-9) 1-nitro- 2 -butanol (3 1 56-74-9) 2 -nitro-1 -butanol (609-31-4) 2-Methyl-2-nitro-1-propanol (76 — 39 — 1) C 5 Nitro alcohol (R) -3-methyl-3-nitro- 2-butanol (1542 7 8-2 7-0) 3 -methyl-1 -nitro-1 -butanol (153977 — 2 0-9) Printed by the Shellfish Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs' (±) —1 — nitro-1 —pentane Alcohol (1 447 1 9 — 64 -6) (S) —1 Mononitro-3 —pentanol (1 44 1 39 — 35 —5) (R) — 1-Nitro-3 —pentanol (144139 — 34 -4) (R)-3 —Methyl—1-nitro-2-butanol (This paper size applies to China National Standard Soap (CNS) A4 (210X297 mm) -288-426663 Λ Β7 Central Ministry of Economic Affairs Printed by the Bureau of Consumers of the Bureau of Standards on the Five Inventions (286) 1 4 1 4 3 4-9 8 — 2) (Earth) -3 Monomethyl — 1 — Nitro — 2 — Butanol (1 4 1 3 7 7 -5 5 — 1) (R comes, R *) — 3 — nitro — 2 — pentanol (1 3 8 7 5 1 — 7 2 — 1) (R *, S *) — 3 —nitro- 2 —pentanol C 1 3 8 7 5 1 — 7 1 — 0) (RR *) — 2 —nitro — 3 —pentanol (1 3 8 6 6 8 — 2 6 — 5) (R S S *) — 2 mononitro — 3 — pentanol (1 3 8 6 6 8 — 1 9 — 6) 3 — nitro 1 — pentanol (1 3 5 4 6 2 — 9 8 — 5) (R)-5-nitro-2-pentanol) 1 2 9 5 2 0-3 5-0) (S)-5-nitro-2-pentanol (1 2 0 2 9 3 — 7 5 — 6) 4 —nitro- 1 —pentanol (1 1 6 4 3 5 — 6 4 — 4) (Earth) -3 —methyl — 3 —nitro — 2 —butanol (1 1 4 6 1 3 — 3 0 — 8) (S) -3 —methyl — 3 —nitro — 2 monobutanol (1 0 9 8 4 9-5 0 — 5) 3 — methyl one 4 — Nitro— 2 —butanol (9 6 5 9 7 — 3 0-T) (+) -5 Nitro — 2 —pentanol (7 8 1 7 4 — 8 1 — This paper size is in accordance with Chinese National Standard (CNS) Α4 size (21〇 × 297mm) -289-4 2 6 6 6 3 A7

A B7 Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs 5. Description of the invention (287) 9) 2 Monomethyl-2 Nitro- 1-butanol (7 7 3 9 2 5 5 — 3) 3 — A — 2 —nitro — 1 -butanol (7 7 3 9 2 — 5 4 — 2) 3 —methyl — 4 mononitro — 1 -butanol (7 5 6 9 4 — 8 9 — 2) 2 — Methyl mono 4-nitro-2-butanol (7 2 1 8 3 — 5 0 — 7) 3 — Methyl mono 3-nitro — 1 — butanol (6 5 1 0 2 — 5 0 — 3 ) 5 —nitro- 2 monopentanol (5 4 0 4 5 — 3 3 — 9) 2 —methyl-3 monoacid — nitro-2 —butanol (2 2 9 1 6 — 7 9 — 6 ) 2-Methyl 1-Acidic-Nitro-2-Butanol (2 2 9 1 6-7 8-5) 2-Methyl-3 Mononitro-2-Butanol (2 2 9 1 6 — 7 7 — 4) 2 —methyl-1 1-nitro- 2 —butanol (2 2 9 1 6 7 6 — 3) 5 —nitro- 1-pentyl alcohol (2 1 8 2 3 — 2 7 — 8) 2 —methyl- 3 -nitro — 1 —butanol (2 1 5 2 7 — 5 3 — 7) 2 mononitro-3 monopentanol (2 0 5 7 5 — 4 0 — 0) This paper size is applicable to China National Standard (CNS) A4 specification (210X297 mm) -290-Staff Consumption of Central Bureau of Standards, Ministry of Economic Affairs Printed by the cooperative 4 2 6 6 6 3 ^ A7 __B7_ __ V. Description of the invention (288) 3 -methyl-1 3 -nitro-2 -butanol (20 5 75-38-6) 3 -nitro-2- Amyl alcohol (5447-9 9 — 4) 2 -nitro-1 -pentanol (2899 -90 — 3) 3-methyl-1 1nitro-2 -butanol (2 2 2 4 — 3 8 — 6 ) 1-nitro- 2 -pentanol (2224-37 — 5) C 6nitro alcohol (-)-4 -methyl- 1-nitro- 2 -pentanol (158 072-33-4) 3- (Nitromethyl) -3-pentanol (156544-56-8) (R *, R *) — 3-methyl-2-nitro-3-pentanol (148319-17-9) (R *, S *) —3-Methyl-2—Nitro-3—pentanol (148319-16-8) 6—Nitro-2—hexanol (146353 — 95 — 9) (±) — 6 Nitro-3 -hexanol (144179-63 -5) (S)-6 -Nitro-3 -hexanol (144139-33 -3) (R)-6 -Nitro-3 -hexanol (14139- 32 — 2) _ Chinese paper standard (CNS) Λ4 specification (2 [0X 297 mm) (Please read the precautions on the back before filling this page)

-291-4 2 6 6 6 3 ^ A7 B7 Μ Printed by the Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs 5. Description of the invention (289) 1 | 3 — Nitro — 2 — Hexanol (1 2 7 1 4 3 1 5 2 — 6) 1 I 5 — nitro — 2 — hexanol (1 1 0 3 6 4 — 3 7 — 9) 1 I 4 — methyl — 1 — nitro — 2 — pentanol (1 0 2 0 1 4 — 1 1 first 1 4 4 — 8) Read I (R wood, S *) _ 2-methyl- 4-nitro_ 3 monopentanol (back rain 1 I of 1 Note I 8 2 9 4 5 2 9 7) Remarks about Qin-[I (R wood, R *) — Q monoethylmethyl — 4-nitro — 3 — pentanol (8 2 9 4 5 — 2 0 — 8) Page, containing 1 2 —methyl-1 —nitro — 2 —pentyl alcohol (7 9 9 2 8 — 6 1 1 I — 3) 1 1 | 2 3 — dimethyl-1 — nitro-1 —butane Alcohol (6 8 4 5 4 1 1 order — 5 9 one 1) 1 2 monomethyl — 3 —nitro — 2 — pentanol (5 9 9 0 6 — 6 2 1 1 — 6) 1 1 3 &gt; 3 — dimethyl-1 — nitro-2 — butanol) 5 8 0 5 4 1 f Quan 8 8 — 9) I 2 »3 — dimethyl-3 — nitro-2 — butanol (5 1 4 8 3 1 1 | — 6 1 — 5) 1 1 2 — Methyl — 1 — nitro — 2 — pentanol (4 9 7 4 6 — 2 6 1 1 — 1) i 1 3 3 — dimethyl-2 — nitro-1 monobutanol (3 7 4 7 7 1 j — 6 6 — 0) ij 6 — nitro — 1 — hexanol (3 1 9 6 8 — 5 4 — 4) 1! 1 2 monomethyl-3 nitro — 1 — pentanol (2 1 5 2 7 1 5 5 1! This paper size is in accordance with Chinese National Standard (CNS) A4 (210X 297 mm) -292-Α7 Β7 V. Description of the invention (290) -9) 2,3-Dimethyl-1 3 — Nitro-1 monobutanol (21527 -54-8) 2 -methyl-4 mononitro-3 3-pentanol (20570 — 70 —1) 2-methyl-1 2-nitro-3 -pentanol (20570 — 67 -6). 2 -Nitro-3 -hexanol (5448-00-0) 4 -Nitro-3 -hexanol (5342-71-2) 4 -Methyl-4 -nitro-1 -pentyl alcohol (52 1 5 — 92 — 9) 1-nitro- 2 -hexanol (2224 — 40-0) C 7nitro alcohol 1 mono-nitro-4 -heptanol (167696-66-4) (R)- 1-Nitro-4-Heptanol (146608-19 -7) Printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs 7-Nitro-1-Heptanol (133088 — 94-5) (R *, S *)- 3-nitro- 2 -heptanol (127143-73-1) (R *, R *) — 3-nitro-2 -heptanol (1 27 1 43 -72-0) (R *, S *) — 2 -Nitro-3 -heptanol (127143 -71-9) This paper size applies to China National Standard (CNS) A4 (210x297 mm) '-293-A7 B7 ^ 26663: V. Description of the invention (291 ) (R *, R *)-2-Nitro-3-heptanol (127143 —7 0 — 8) (R * 'S *) — 2 -Methyl-5 -nitro-3 -hexanol (1 03077-95-8) (R *, R *)-2 -methyl- 5 -nitro- 3 -hexanol (103077-87-8) 3 -ethyl-4 -nitro-1-pentanol ( 92454-38 — 1) 3 —ethyl — 2 —nitro-3 —pentanol (77922 — 54 -4) 2 —nitro-3 —pentane Alcohol (6 1 097-77-6) 2 -methyl-1 -nitro-3-hexanol (35469-17 -1) 2 -methyl-4-nitro-3-hexanol (20 5 70- 7 1-2) 2 -methyl- 2 -nitro-3-hexanol (20570-69 8) 5-methyl- 5 -nitro- 2 -hexanol (7251-87-8) 1 -nitro —2 -heptanol (6 3 02-74 — 5) 3-nitro-4 -heptanol (5462-04- 4) 4 —nitro-3 —heptanol (5342-70-1) C 8 Alcohol _ This paper size applies to China National Standards (CNS) A4 (210X 297 mm) -294-426663 A7 B7 Printed by the Consumers' Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs 5. Inventive Notes 292 292) (Soil) — 1- Nitro-3-octanol (1 4 1 9 5 6-9 3-6) 1-Nitro- 4-octanol (1 6 7 6 4 2-4 5-7) (S)-1-Nitro Mono 4-octanol (1 6 7 6 4 2 — 1 8-4) 6-methyl 6-nitro-2-heptanol (1 4 2 9 9 1 — 7 7 — 3) (R Ben, S *) — 2-nitro — 3 — octanol (1 3 5 7 6 4 — 7 4 — 8) (R * , R *) -2-Nitro-3-octanol (1 3 5 7 6 4 — 7 3 — 7) 5-Nitro-4-octanol (1 3 2 2 7 2 — 4 6 — 9) ( RR ”-3-nitro-4-octanol (1 3 0 7 1 1-7 9-4) CR this, S _ Q -10 nitro-4-octanol (1 3 0 7 1 1 — 7 8 — 3) 4 —ethyl- 2 -nitro — 3 —hexanol (1 2 6 9 3 9 — 7 4 — 0) 2 —nitro — ~ 3 -octanol (1 2 6 9 3 9 — 7 3 — 9) 1 — nitro- -3 monooctanol (1 2 6 4 9 5 — 4 8-5) (R 3Lg R *) — (earth) — 3 — nitro — 4 — octanol (1 1 8 8 6 9--2 2-0) (R * S *)-(Earth) — 3 —Nitro-4 —octanol (1 1 8 8 6 9 -2 1 — 9) Please read it Note: ▲ The paper size of this page applies to the Chinese National Standard (CNS) Α4 specification (2 [0 × 29? Mm) -295-4 2β6 6 3 Α7 Β7 Printed by the Staff Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs 5. Description of the invention (293 ) 3 — Nitro — 2 — Octanol (1 2 7 1 4 3 — 5 3 — 7) (R Ben '5 *) — 2 — Methyl-5 — Nitro — 3 — Heptanol (1 0 3 0 7 8 — 0 3 — 1 ) (R Ben, R *) — 2 —methyl-5 — nitro — 3 — heptanol (1 0 3 0 7 7 — 9 0 — 3) 8 — nitro — 1 — octanol (10 1 9 7 2 — 9 0 — 1) (Earth) — 2 — Nitro — 1 —Octanol (9 6 0 3 9 — 9 5 — 1) 3 4 — Dimethyl — 1 — Nitro — 2 — Hexanol (6 4 5 9 2 — 0 2 — 5) 3 — (nitromethyl) — 4 —heptanol (3 5 4 6 9 — 2 0 — 6) 2 5 — dimethyl — 1 — nitro3 — hexanol ( 3 5 4 6 9 — 1 9 — 3) 2 — methyl — 1 — nitro — 3-heptanol (3 5 4 6 9 — 1 8 — 2) 2 1 4 7 4 — ~ methyl-1 — nitrate — 2 monopentanol (3 5 2 2 3-6 7 — 7) 2 5 — dimethyl — 4 — nitro — 3 — hexanol (2 2 4 8 2 — 6 5 — 1) 2 — nitro — 1 monooctanol (2 8 8 2 — 6 7 — 9) 1 — nitro — 2 — octanol (2 2 2 4 — 3 9 — 7) C 9 nitrate The base paper size is based on the Chinese National Standard (CNS) A4 specification (21 × 297 mm) -296-4 266 6 3 a7 Λ Printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs 5. Description of the invention (294) 1 I 4 — Nitro- 3 — Nonanol (1 6 0 4 8 7 — 8 9 — 8) 1 1 I (R ice, R *) — 3 — Ethyl — 2 — Nitro — 3 — Heptanol (1 1 | 1 4 8 3 1 9-1 8 _ 0) 1 I please 1 | 2 &gt; 6 mono-methyl-6 mononitro-2-heptanol (read 1 1 1 7 0 3 0-5 0 — 9) Back 1 1 1 1 (R wood, S *) — 2 — Nitro-4 monononanol (1 0 3 0 7 7 Note ancient 1 1 9 9 — 6) Ψ. Item 1 1 (R wood , R *) — 2 mononitro-4 monononanol (1 0 3 0 7 7 1 — 8 5 — 6) &gt; — t 2 — nitro- 3-nonanol (9 9 7 0 6 — 6 5 — 7) 1 I j 9 mono-nitro- 1 — nonanol (8 1 5 4 1 — 8 4 — 6) 1 Order 1 2 Monomethyl 1 — Nitro — 3 — Octanol (5 3 7 1 1 — 0 6 — 1) 1 1 4 Mono Nitro — 5 — Nonanol (3 4 5 6 6 — 1 3 a 7) 1 [2 monomethyl a 3 (nitromethyl) — 3 —. Heptanol (5 5 8 2 — 1 [8 8 a 7) 1 1 1 — nitro — 2 — Nonanol (4 0 1 3 — 8 7 — 0) 1 1 1 C 1 Π Nitro alcohol 1 1 1 2 — Nitro-4 — Decanol (1 4 1 9 5 6 — 9 4 — 7) I 1 1 (R * 1 S *) — 3 — nitro — 4 — decanol (1 3 5 7 6 4 1 1 — 7 6 — 0) i 1 (R *, R *) — 3 mononitro — 4 — decyl Alcohol (1 3 5 7 6 4 i 1 — 7 5 — 9) 1 1 This paper size applies to Chinese national standards (CNS &gt; Λ4 size (210X297 mm) -297-426663 A7 B7 Printed by the China Bureau of Standards, the Ministry of Economic Affairs, and printed by the Consumer Cooperative. V. Description of the invention (295) 1 | 5 »5-dimethyl — 4 — (2 mononitroethyl) — 1 — hexanol (1 1 13 3 0 8 8 — 9 6 — 7) 1 i | (R wood-R *) — (soil) a 3 —nitro — 4 —decanol (1 V [please j 11 8 8 6 9-2 0 — 8) first 1 Reading | Poetry! (R, S *) — (Earth) — 3 — Nitro-1, 4-decyl alcohol (back 1 side | 11 8 8 6 9 — 1 9 — 5) ί Thing 1 5 — Nitro-1 2 — Decanol (1 1 2 8 8 2 — 2 9 — 8) Item ί d -χ 3 — Nitro-4 — Decanol (9 3 2 9 7 — 8 2 — 6) Poultry f 4 »6, 6 — Trimethyl — 1 — Nitro — 2 — Heptanol (N — ^ II 8 5 9 9 6 -7 2 — 1) 1 ir 2 — Methyl 2- 2 Nitro — 3 — Nonyl Alcohol (8 0 3 7 9 — 1 7 ί 1 -5) Order 1 1 mononitro — 2 —decanol (6 5 2 9 9 — 3 5 — 6) 1 2 2, 4 »4 — tetramethyl — 3 — (nitromethyl) — 3 — pentyl 1 j alcohol (5 8 2 9 3 — 2 6 _ 8) ί Ί C 1 1 nitro certain alcohol J 1 1 1 — nitro — 5 — 5 ten ten ~ * alcohol (1 6 7 6 9 6 — 6 9 1 1 -7) 1 1 (R Song, R *) 1 2 —Nitro — 3 —Undecanol (1 1 1 4 4 4 3 5 6 — 0) 1 I (R *, S * ) — 2 —nitro — 3 —undecanol (f 1 Ι 14 4 4 3 4 —5 5 — 9) 1 1 I 2 —nitro — 3 —undecanol (1 4 3 4 6 4 — 9 2 — 0) 1 1 This paper size applies the Chinese National Standard (CNS) A4 ^ (210X297 mm) -298-A7 B7 Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs 426663 V. Description of Invention (296) 2, 2 — Dimethyl-1, 4-nitro-1, 3-nonyl alcohol (126939-76-2) 4, 8-dimethyl-2, 2-nitro-1, nonyl alcohol (118304-30-6) 11-nitro-1 -Undecyl alcohol (81541 — 83 — 5) C 1 2nitro alcohol 2-methyl-1 2-nitro-3 -undecanol (126939 — 7 5 — 1) 2-nitro-1dodecanol (62322-32 — 1) 1-nitrate — 2 — ten Diol (62322 — 31-0) 2 —Nitro-3 —dodecanol (82981 -40 — 6) 12 —Nitro-1 —dodecanol (81541 — 78-8) Table 2 6 — Formula rule 5 〇rich Exemplified Compound Aldrich No.) (CAS No./ 3-bromo-propanol 627189 167169 1, 3-dichloro-2-propanol 9 62 3 1 184489 3-chloro-2, 2-dimethyl 1-propanol 13401564 189316 2, 2-bis (chloromethyl) -propanol 5355544 207691 1, 3-difluoro-2-propanol 453134 176923 2- (methylthio) ethanol 5271385 226424 2- (di Butylamine) ethanol 102818 168491 The paper size is applicable to the Chinese National Standard (CNS) A4 specifications Ø 210X297 mm) (Please read the precautions on the back before filling ¾. This page)

-299 42666 3 ^ a7 ________B7 V. Description of the invention (297) Printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs 2_ (diisopropylamino) ethanol 96800 168726 3-methyl-3-butene-1-enzyme 763326 129402 2 -Methyl-3-buten-2-ol 115184 138816 3 monomethyl-2-butanol 556821 162353 4-hexan-1-ol 928927 237604 5-hexen-1-ol 821410 230324 cis-2- Hexan-1_ol 928949 224707 trans-3-hexyl-1_ol 928972 224715 trans-2-hexene-1-ol 928950 132667 methyl-5-heptan-2-ol 4660062 195871 dihydrogeranene Alcohol 18479588 196428 trans, trans-2, 4-B diene-butanol 17102646 183059 2,4-dimethyl-2,6-heptadiene-: 1-ol 80192569 238767 saponin 106241 163333 3-butane Alkyne-butanol 927742 130850 3-pentan-1-ol 10229104 208698 isethionate, sodium salt 1562001 220078 (4- (2-hydroxyethyl) -1-hexahydropyridyl- 16052065 163740 propanesulfonic acid HEPES , Sodium salt 75277393 233889 dimethylcyclopropanemethanol 2746147 236594 2-methylcyclopropanemethanol 6077721 233811 (+ /-)-permethrin 18383590 194654 cyclobutanemethanol 4415821 187917 Chinese National Standard (CNS) Λ4 specification (2 Shu 〇X297 mm) 4266 6 3 Μ Α7 Β7 V. invention will be described (not 8)

Central Standards Bureau, Ministry of Economic Affairs, Consumers Cooperative, India I 3-Cyclopentyl-Propanol 767055 187275 1-Ethynylcyclopentanol 17356193 130869 3-methylcyclohexanol 591231 139734 3, 3, 5, 5-Tetramethyl Cyclohexanol 2650400 190624 4-Cyclohexyl-butanol 4441570 197408 Dihydrocarvrol 619012 218421 (IS, 2R, 5S)-(+)-menthol 15356704 224464 (IS, 2R, 5S)-(+) -Neomenthol 2216526 235180 (IS, 2R, 5S)-(+) -isomenthol 23283978 242195 (+ /-)-3-cyclohexene-bumentol 72581329 162167 (+)-P-Meng-1- Alcohol 13835308 183741 (s)-(-)-violet alcohol 536594 218391 terpinen-4-ol 562743 218383 α-coldol 9 85 5 5 218375 (+/-)-trans-? -:-6-ene-2,8-diol 32226543 247774 cycloheptane methanol 4448753 138657 tetrahydrofuran methanol 9 7 9 94 185396 (S)-(+)-2-pyrrolidine methanol 23356969 186511 1-methyl-2- Pyrrolidine ethanol 67004642 139513 1-ethyl-4-hydroxyhexahydropyridine 3518830 224634 3-hydroxyhexahydropyridine hydrochloride 64051792 174416 (+ /-)-2-hexahydropyridine methanol 3433372 155225 3 -hexahydropyridine Methanol 4606659 155233 1-Methyl-2-Hexahydro-methanol Methyl-3-hexahydropyridine methanol 7853531 146145 2-hexahydropyridine ethanol 1 84840 131520 4-hydroxyhexahydropyridine 5382161 128775 4-methyl-buhexahydropyrrol propanol 5317339 238716 outer-orbornenol 497370 179590 inner -Orbornenol 497369 186457 5-orbornenyl-2-methanol 95125 248533 (+/-)-3-methyl-2-orbornylmethanol 6687568 130575 ((1S) -inside)-(+) -borneol Enol 464459 139114 (1R) -endo-(+)-alcohol 2217029 196444 9-ethylbicyclo (3, 3, 1) non-9-alcohol 21951333 193895 (+ /-)-Isopinol 51152115 183229 (S) -cis Verbenalic acid (verbenol) 18881044 247065 (lR, 2R, 3R, 5S)-(-)-Isopinol 25465650 2 2 1 9 0 2 (1R) _ (-)-Myrtenol 515004 188417 1-Adamantanol 768956 130346 3, 5_ —Methyl ™ 1_Amantanol 707379 231290 2-Amantanol 700572 153826 1-Adamantane methanol 770718 184209 1-adamantane ethanol 6240115 188115 3-furan methanol 4412913 196398 furan methyl alcohol 980 00 185930 2- (3-phenylphenyl) ethanol 13781674 228796 4 monomethyl-5_imidazole methanol hydrochloride 38856625 227420 Applicable to this paper size Chinese National Standard Grid (plus ^ 426663 A7 B7 Printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs 5. Description of the invention (300) metronidazole 443481 226742 4- (hydroxymethyl) imidazole hydrochloride Salt. 32673419 219908 4-methyl-5-P * azole ethanol 137008 190675 2- (2-hydroxyethyl) pyridine 103742 128643 2-hydroxy-6-methylpyridine 3279763 128740 4-pyridylmethanol 586958 151629 3 -B Bismethyl alcohol N-oxide 6968725 184446 1-benzyl-4-hydroxyhexahydropyridine 4727 724 152986 1- (4-chlorophenyl) -1-cyclopentanemethanol 80866791 188697 (4S, 5S)-(-)-2 -methyl-5-hexyl-2-oxazolyl-4-methanol 53732415 187666 6- (4-Chlorophenyl) -4,5-diargon 2- (2-hydroxybutyl) ~ 3 (2H) -datralone 38988826 243728 N- (2-hydroxymethyl) phthalaldehyde Amine 3891074 138339 2-Ethanol 1485070 188107 Ethanol 773999 183458 2-Isopropylphenol 886 97 129526 4-Chloro-α, α-dimethylphenethyl alcohol 5468973 130559 4-Fluoro-α-methylbenzyl alcohol 403418 132705 3-phenyl-1-propanol 122974 140856 3_ (4-methoxyphenyl) -propanol 5406188 142328 4-fluorophenylethanol 7589277 154172 4-methylphenylethanol 702238 154180 trans-2-methyl- 3-phenyl-2-propen-1-ol 1504558 155888 The paper size is applicable to the Chinese National Standard (CNS) Λ4 specification (21〇 &gt; &lt; 297mm) -303-4266 6 35. Description of the invention (301)

A A7 B7 The Ministry of Economic Affairs, China Standards Bureau, Shellfish Consumer Cooperation, Du printed 2-aniline ethanol 122985 156876 3-fluorobenzyl alcohol 456473 162507 2-fluorobenzyl alcohol 446515 162515 2-methyl-1-propenyl alcohol 100867 170275 α -(Chloromethyl) -2,4-dichlorobenzyl alcohol 13692143 178403 2-phenyl-1-propanol 1123859 179817 4-chlorophenylethanol 1875883 183423 4-bromophenylethanol 4654391 183431 4-nitrophenylethanol 100276 183466 2 -Nitrophenyl alcohol 15121843 183474 million-Ethylbenzene ethanol 2035941 183482 4 -Phenylbutanol 3 36 04 1 6 184756 2-Methoxyethanol 7417187 187925 3-Methoxyethanol 5020417 187933 3-Phenyl-1-butane Alcohol 2722363 187976 2-methylphenylethanol 19998988 188123 3-methylphenylethanol 1875894 188131 4-methylphenylethanol 699025 188158 5-phenyl-pentyl alcohol 10521912 188220 4- (4-methoxyphenyl) -butyltin Alcohol 22135508 188239 4- (4-Nitrophenyl) -1-butanol 79524202 188751 3, 3-Diphenyl-1-propanol 2001017678 188972 Phenyl-2-propanol 14898874 189235 (+ /-)-α -Ethyl ethyl alcohol 701702 190136 (please read the note on the back first and then fill in this page) China National Standard (CNS) Λ4 Specification (210X297 mm) -304 ™ 4 266 6 3 ^ V. Description of Invention (30.2) A7 B7 Printed by 1,1-diphenyl- 2-propanol 29338496 190756 3-chlorophenylethanol 5182445 193518 2-chlorophenylethanol 19995955 193844 (+ / _) _ 1-phenyl-2-pentanol 705737 195286 2, 2-diphenylethanol 1883325 196568 4-ethoxy 3-Methoxyphenylethanol 77891293 197599 3,4-dimethoxyphenylethanol 7417212 197653 3- (3,4-dimethoxyphenyl) -1-propanol 3929473 197688 2- (4-bromophenoxy) Ethyl alcohol 34743889 198765 2-Fluorophenylethanol 5091967 228788 3- (Trifluoromethyl) phenylethanol 455016 230359 2- (phenylthio) ethanol 699127 232777 Bu (2-methoxyphenyl) -2-propanol 15541261 233773 (Please read the precautions on the back before filling out this page) The size of the paper used for this edition applies to the Chinese National Standard {CNS) 8-4 specifications (2 丨 〇X 297 mm) -305 4 266 6 3 A7 B7 V. Description of the invention (3〇 3) Table 2 7 —Method A — R Method specific examples A; B; C; D; I; J; K; L; Μ; Ν; Ο; P; Q; R; E; F; G; Η; AB; BC; CD; DI; IJ; JK; KL; LM; MN; NO; OP; OQ; QR; EF; FG; GH; HI; ABC; BCD; CDI; DIJ; IJK; JKL; KLM; LMN; MNO; NOP; NOQ; OQR; EFG; FGH; GHI; HIJ; ABDC; BCDI; CDIJ; DIJK; IJKL; JKLM; KLMN; LMNO; MNOP; MNOQ; NOQR; EFHG; FGHI; GHIJ; HIJK; ABCDI; BCDIJ; CD1JK; DIJK B; 玎 KIM; JtOLMNOP; KLMNO; LMNOQ; MNOQR; EFGHI; FGHIJ; GHP :; HIJKL; ABCDIJ; BCDIJK; CDIJKL; D1JKLM; IJKLMN; JKLMNO; KLMNOP; KLMNOQ; LMNOQR; EFGHIJ; FGH1JK; GHIJKK ;; AHIDI ; JKLMNOa- KLMNOQR; EFGHIJK; FGHIJKL; GHIJKLM; HP: LiMN; ABCDIJKL; BCDIJKLM; CDIJKLMN; DIJKLMNO; IJKLMNOP; IJKLMNOQ; JKLMNOQR; EFGHIJKL; FGHIJKLM; GHIJKLMN; HIJKLMNO; ABCDiJKLM; BCDIJKLMN; CDIJKLMNO; DIJKLMNOP; DIJKLMNOQ; IJKLMNOQR; EFGHIJKLM ; FGHIJKLMN; GHIJKLMNO; HIJKLMNOP; HIJKLMNOQ; ABCDIJKLMN; BCDIJKLMNO; CDIJKLMNOP; CDIJKLMNOQ; DIJKLMNOQR; HFGHIJKLMN; FGHIJKLMNO; GHIJKLMNOP; GHIJKLMNOQ; HIJKLMNOQR; ABCDIJKLMNO; BCDIJKLMNOP; BCDIJKLMNOQ; CDIJKLMNOQR; EFGHIJKLMNO; FGHIJKLMNOP; FGHIJKLMNOQ; GHIJKLMNOQR; ABCDIJKLMNOP; ABCD IJKLMNOQ; BCDIJKLMNOQR; EFGHIJKLMNOP; EFGHIJKLMNOQ; FGHIJKLMNOQR; ABCDIJKLMNOQR; EFGHIJKLMNOQR; S; T; U; V; W; ST; TU; UV; VW; STU; TUV; UVW; STUV; TUV. Note on this page again) rr- Binding, binding, travel. M-sheets printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs are applicable to the Chinese Family Standard (CNS) A4 grid (210X297 public completion) 306 426663 A7 B7 V. Description of the invention (304) Reaction diagram 41 h3co

co2ch3 H3C〇v ^ 〇 /, ^ wC〇2CH3

BocHN rr n3 301

OH

BocHN N3 302 N3

BocHN 303

OPMB Please read the notes of the memorandum first!

OPMB

&lt; y n3

OPMB 305 OPMBΗN &lt; ^ — N3 306 Order

BocnCQ ^

Printed by OPMB Employee Cooperatives, Central Standards Bureau, Ministry of Economic Affairs N3 307

310

OH

AcHN ^ i N3

OPMB 309

This paper size is in accordance with Chinese National Standard (CNS) 8-4 specification (21 × 297 mm) h% -307-4266 6 3 A7 ____ * _______ B7_ 5. Description of the invention (305) Reaction fH 4 1 Treatment of amine with B oc anhydride 3 Ο Ο (The intermediate of Example 5 2 can be purified arbitrarily before use) to give a single B oc protected amine 3 Ο 1. This conversion can be referred to Greene, T.W. ^ Protective Groups in Organic Synthesis' ’2nd Ed. (John Wiley &amp; Sons,

Mew York, 1991) pp. 327-328 · Methyl ester 3 0 1 is reduced to the corresponding primary allyl alcohol 3 0 2 with DIBAL at low temperature »This conversion is such as Garner, P and Park, J. M., 'J. Org.

As described in Chem /, 52-236 1 (19 87), the higher alcohol 3 0 2 is protected with p-methoxybenzyl ether derivative 3 0 3 by treatment with 4-methoxymethoxy chloride under basic conditions. This transformation is as described by Horita, K et al. &Gt; 'T e t r a h e d r ο η', 4 2: 3 0 2 1 (1 9 8 6). The MOM and β oc protecting groups of 3 0 3 were removed by treatment with TFA / CH2C iZ 2 to make amine alcohols 3 0 4-this transformation is as Greene, TW Protect Groupve Groups in Organic Synthesis', 2nd. Ed. ( John, Wiley &amp; Sons, New York, 1 9 1 1). Printed by the Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs of the People's Republic of China, 3 0 4 was converted to the corresponding trityl protected aziridine 3 0 5 in a two-step reaction in a single reaction vessel: 1) TrCi? / TEA / TEA. This transformation is as described above, and then aziridine 3 05 is converted to the corresponding B 0c protected derivative 3 07 as described below. First remove the trityl group with H C acetone to obtain 3 06. This transformation is as Hanson, R.W. and Law, H. D. 'J.

As described in Chem. Soc. ^ 7285 (1965), nitrogen (CNS) (21 OX 297 / ^ ¾) was treated with B oc anhydride. '* &Quot; -308-* 4 266 6 3, a7 ____ B7 V. Description of the invention丨 ㈣) Propidium 306 was converted to the corresponding Boc derivative 30.7. This conversion was as described in Fitremann, J. et al., ^ Tetrahedron Lett. ', 35: 1 20 1 (1 994). Allyl nitrogen Propidium 3 0 7 is a carbon nucleophile (via a high-valent organic copper salt) in the presence of BF3 · E t2 0, and at the low temperature, is selectively ring-opened at the allyl position to obtain a ring-opening adduct 3 0 8 . This open loop is as described by Hudlicky, T. et al. &Quot; Synlett, 1 1 2 5 (19 9 5). In a two-step procedure: 1) TFA / CH2Cj? 2; 2) A c20 / pyridine converts the B oc protected amine 3 0 8 into N-ethylfluorenyl derivative 3 0 9 * This conversion can refer to Greene, TW, '

Protective Groups in Organic Synthesis #, 2nd, Ed. (John Wiley &amp; Sons, New York, 1991) pp. 3 2 7- 328 and p. 351-352. The benzyl ether 3 0 9 was deprotected to primary allyl alcohol 3 1 0 with DD Q at room temperature. This transformation is described by Horita, K. et al. 'Tetrahedron' 4 2: 3 0 2 1 (1 986). The printed alcohol 310 of the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs was oxidized and converted into methyl ester 311 in a single reactor, and was completed by Corey oxidation with Mn02 / Ac0H / Me0H / Na CN. This conversion is as Corey, EJ Et al. &Quot; M. Am. Chem. Soc, 9 0:56 1 6 (1 96 8). The azide ester 3 1 1 is subjected to a two-step reaction procedure: 1) Ph3P / H20 / THF: 2) KOH / THF is converted to an amino acid 3 1 2. This transformation is as described above. This paper size applies to National Standards (CNS) Α4 specifications (210 × 297 mm) ^ -309-4 266 6 3 λ Β7 Printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs

-310-Α7 Β7 4 266 6 3 λ V. Description of the invention (308) Reaction Figure 4 2 Known fluoroacetate 3 2 0 (Sutherland, JK et al. 'J. Chem. Soc. Chem. Commun. ^ 464 (1 993) deprotected to free alcohol and then converted to the corresponding mesylate 321: 1 in two steps) «

NaOMe; 2) MsC / TEA. This transformation is, for example, Greene, T.W., '&quot; Protective Groups in Organic Synthesis ^, 2 nd · E d _ (J ohn W i I ey &amp; S ο ns, N e isr Y ork, 1 9 9 1) . Deprotection of 3 2 1 under acidic conditions yields a diol 3 2 2 which is completed in the following order: 1) MOMCj ^ / TEA; 2) NaN3 / NH4Cj?; 3) MsCJ? / TEA; 4) PPh3 / TEA / H20; 5) NaN3 // NH4CJ ?; 6) HCJ? / MeOH; 7) i) TrCJ ?, ii) MsCJ? / TEA. This sequence is as described above. The aziridine 3 2 4 is then ring-opened with a suitable alcohol under the condition of Lewis acid, and then treated with A c 02 / pyridine to obtain the ethylated product 3 2 5. This transformation is described above. The ester 3 2 5 printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs was converted into the corresponding amino acid 3 2 6 through the following two-step procedure: 1) PPh3 / H20 / THF; 2) KOH / TH F. This conversion is as described above "U.S. Patent No. 5 2 1 4 1 6 5 * especially the 9th row from the 61st row to the 18th column from the 26th row * D eseripti ο nsand Ε X am ρ I es", Describe the preparation of 6α and 6j9 fluoroshikimic acid. These fluorine compounds are suitable as starting materials for the shikimic acid used in the method for preparing the compounds of the present invention. The paper size of the paper is applicable to the Chinese National Standard (CNS) sixty four specifications (210X 297 male pan: ) 311 266 6 3 A7 B7 V. Description of the invention (309) Reaction chart 43 CO2C H3 〇 ′ 、， · 'OAc R'

331 330 R '

332

333

u

R 'TrN

C02CH3 334 n3335 ---------------- W ------ Λ A) (Please read the precautions on the back before filling this page) Ministry of Economic Affairs, China Standards Bureau R 'printed by employee consumer cooperatives

337 The size of this paper applies Chinese National Standard (CNS) A4 (2 丨 〇297297 mm) -312-A7 B7 4 2 66 6 3, V. Description of the invention (310) Reaction diagram 4 3 Unsaturated ester 3 3 0 (Made from pyruvate alcohols by standard ethionization 'as described in Campbell, MM et al.,' Synthesis', 179 (1993)) and suitable organic copper salts (where R &gt; The former) reaction, the resulting intermediate reacted with Ph S e C J2 to give 33 1 and then treated with 30% H 2 0 2 to obtain α, / 5-unsaturated ester 3 3 2. This conversion can refer to Hay ash i, Υ. et al., 'J. Or g. Chem, 47: 3428 (1 9 82). Then in a two step procedure: 1) NaOMe / MeOH; 2) Ms C $ / TEA acetate 3 3 2 Conversion to the corresponding mesylate 3 3 3 »This conversion is as described above, and reference can be made to Greene, T / f., '

Protecΐive Groups iη 0rganic Synthesis ’, 2nd. Ed · (J o h n W i 1 e y &amp; S ο n s, N ur Y or k, 1 9 9 1). Then a two-step procedure: 1) P-T s OH / Me 0Η / Λ; 2) DBU / THF converts acetone 333 to epoxy alcohol 334 * This conversion is as described above. The epoxide 3 3 4 printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs is converted into N-trityl aziridine 335 by the following procedure: 1) MOMC ^ / TEA; 2) NaN3 / NH4C ^; 3) MsCJ? / TEA; 4) PPh3 / TEA / H20; 5) NaN3 // NH4Ci2; 6) HCJ2 / MeOH; 7) i) T r C 5-ii) M s C J2 / TEA. This procedure is described above. Then aziridine 3 3 5 is ring-opened with a suitable alcohol under the condition of Lewis acid, and then treated with A c20 / pyridine to obtain the acetylated product 3 3 6. This paper size applies to the Chinese National Standard (CNS) Λ4 specification (210X W7 mm) 4 2 ^ 6 6 3; A7 B7 Five 'Invention description (Ml) The conversion is as described above. The azide ester 3 3 6 is converted to the corresponding amino acid 3 3 7 via a two-step procedure described below: 1) PPh3 / H2O / THF; 2) KOH / ΤΗF. This transformation is described above. The examples will be referred to the reaction diagrams 44 and 45.

AcN _ Η ΝΗο Sickle Figure 44 丨% ^ C02CK3

340 Please read the notice items before / Binding

342 Imprint of the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs 45 h3c〇

CO2CH2CH3 H3CO h3co ^ o //

HO

OH H〇 ^ N3 347 This paper size is applicable to China National Standard (CNS) A4 (21 OX297 mm) -314-4 2 6 6 6 3 ^ A7 ____B7 V. Description of the invention (312) Change the illustrated starting material To form without further elaboration, this article will not repeat them. See F 1 eet, G. W. J. et a 1., 'J. Chem. Soc.

Perkin Trans., 905-908 (1984), Fleet, GWJ et a 1. 'J. Chem. Soc., Chem. Commun. ^, 849 -85 0 (1983), Yee, Ying K · et al .;' J. Med. Cehm.〃, 33: 2437-2451 (1990); Olson, RE et al .; 'Bioorganic &amp; Medicinal Chemistry Letters', .. 4 (18): 2229-2234 (1994); Santella, JB Ill et al .; Bioorganic &amp; Medicinal Chemistry Letters ', 4 (18): 2235-2240 (1 994); Judd, DB et al.;' 2 J. Med. Chem. ^, 37: 3 1 08-3 1 20 (1 994) and Lombaert, S. De et al .;

Bio'organic &amp; Medicinal Chemistry Letters', 5 (2): 15b 154 (1994). The E i sulfur analog of the carboxylic acid compound of the present invention printed by the Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economics is made by any standard technique. As an example and not limitation, the carboxylic acid is reduced to alcohol by standard methods, and then the standard is used. The method converts an alcohol into a halide or a sulfonate, and the resulting compound is reacted with Na S Η to form a sulfide product. Such reactions are described in pa tai, The Chemistry of the Thiol Groups (John Wiley,

New York, 1974), pt. 2, especially at pages 7 2 1-7 3 5. The above-mentioned modification of each reaction chart can obtain various congeners of the above-mentioned specific exemplified compounds. The above-mentioned works that are suitable for organic synthesis methods can be applied to these changes. Liangshanga In the above reaction diagrams, it is better to separate the reaction products and / or separate from the starting materials. The product applies the Chinese National Standard (CNS) Λ4 specification (2U) X297 mm) on this paper scale ~ -315-4266 6 3, _ ^ _ V. Description of the invention (313). Commonly used techniques for separation and / or purification (Collectively referred to as separation below) to the desired uniformity. Typically, this separation involves heterogeneous extraction, crystallization from a solvent or solvent mixture, distillation, sublimation or chromatography. Chromatography can be performed by a variety of methods, such as size exclusion or ion exchange chromatography • high, medium, and low pressure liquid chromatography, thin-layer or preparative thin-layer or thick-layer chromatography, and small-scale thin-layer and rapid chromatography. Another separation method involves treating the mixture with a reagent that is selected to bind (or make it separable) to the desired product, unreacted starting materials, reaction by-products, and the like. Such reagents include adsorbents or absorbents, such as activated carbon, molecular sieves, ion exchange media, and the like. In addition, in the example of the basic substance, it may be an acid, and in the example of the acidic substance, it may be rhenium, or it may be a binding agent, such as an antibody, a binding protein, a selective coupling agent, such as a crown ether. , Liquid / liquid ion extraction agent (LIX), etc. The choice of a suitable separation method depends on the nature of the participating substances. For example, the boiling point and molecular weight during distillation and sublimation, whether there are polar functional groups during chromatography, and the stability of the substance in acidic or alkaline media during multiphase extraction. Those skilled in the art will be able to apply the best techniques to achieve the desired separation results. Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs (please read the precautions on the back before filling out this page) All the documents and patents mentioned above are incorporated herein by reference. The passages or pages specifically cited in the above works are clearly marked by It is mentioned as a reference. The present invention has been described in detail so that those skilled in the art can make and use the following subject matter of the patent application. It should be clear that certain improvements to the method or composition of the patent application are still in the present invention. Within the scope and spirit. Example This paper size applies the Chinese national standard (CNS &gt; Λ4 specification (210X297 mm) A7 B7 428663 &lt; V. Invention description (Magic 4)

逋 -Be tL The following examples are reference reaction diagrams. Some examples were performed several times. In the repeated examples, the reaction conditions (such as time, temperature, concentration, etc.) and the yield were within the normal experimental error range. «If the experiment is repeated with a significant improvement, the results are marked as significantly different Or • If the examples use different starting materials, they are also marked. When used in repeated examples, the "corresponding" homologue of a compound, such as "corresponding ethyl ester", means that another group (in this case, usually a methyl ester) is modified to the group shown. For example, "The corresponding ethyl ester of compound 1 means (Please read the precautions on the back before writing this page)

Printed by the Consumer Cooperatives of the Central Bureau of Standards, Ministry of Economic Affairs, Example 1 Epoxy Alcohol 1: From shikimic acid to McGowan and Berchtold, J. Org. Ch em., 4 6: 2 38 1 (1 9 8 1) The steps are made "Window example 2 Epoxy allyl ether 2: Ethanol was added to a solution of epoxy alcohol 1 (2.3 7 g-14. 0 8 mmo i?) In anhydrous benzene (50 mL) at a time.铊 (I) (ί. OlmL). After 2 hours, it was concentrated in vacuo and the residue was dissolved in acetonitrile. Allyl iodide (3.0 ml) was added and the mixture was allowed to stir in the dark for 16 hours. Diatomite (this paper size applies the Chinese National Standard (CNS) Λ4 present grid (210X297 mm) A7 B7 4 266 6 3 t 5. Description of the invention (315) celite) pad to filter out the solids, and wash with chloroform. After concentration in vacuo, flash chromatography (40% EtOAc in hexane) gave 1.24 (please read the precautions on the back before filling this page) g (42%) 2, which is a light-colored thick oil . 1 H NMR (300MHz, CDC13): 6 6.7.5 (1 1 &gt;m); 6. 10-5. 90 (lH, m, —CH = allyl); 5. 4 0-5. 15 (2H, m, = CH2, allyl): 4.47-4. 43 (lH, m), 4. 3 0-4. 15 (2H, m, -CH2-, allyl); 3. 7 3 (3 Η-s), 3. 5 5-3. 5 0 (1 Η * m), 3. 4 5-3. 4 0 (1 Η &gt; m), 3. 15-3. 00 (lH, dm, J = 19. 5 H z), 2. 50 — 2- 35 (1H · dm · J = 2.7, 19.5 Hz). Printed by the Consumer Standards Cooperative of the Central Bureau of Standards, Ministry of Economic Affairs, Example 3 Azide alcohol 3: Let epoxide 2 (1.17 g * 5. 5 7 mmo), sodium azide (1.82 g) and ammonium chloride (658 mg) was refluxed in MeOH / H20 (8: 1) (35 mL) for 18 hours. The reaction mixture was then concentrated in vacuo and the residue was distributed between ether and water. The organic layer was washed with brine and dried. Concentrated in vacuum to obtain 3, which is a light-colored oil, 1.3 g (92%) The paper size is applicable to the Chinese National Standard {CNS) 4 specifications (21 〇X 297 mm) -318-A7 426663 _ B7 V. Invention Note (sen) can be used directly without purification a ΗΝΜR (3 0 0 M, HZ j CD c 1 3): δ 6. 9 5 — 6 8 5 (1 H »m) r 6. 0 0 — 5 • 8 5 (1 H »my — ch =, allyl) 5. 3 5 — 5 • 2 5 (2 * m * = CH 2 'allyl): 4 • 2 5 — 4 1 0 (2 H m — C Η 2 — 'Suspect C); 4. 1 2 (1 H &gt; bt »J = 4 • 2 H z): 3 • 9 5 3 • 7 5 (2 H m) t 3. 7 7 (3 H 9 s) 1 2. 8 5 (1 H, dd! J = 5 • 3 9 1 8. 3 Η ζ) 2. 7 1 C 1 H 9 bs) f 2. 26 (lH »dd'J = 7.2, 18.3 Η z) ο Example 4 Aziridine 4: Letanol 3 (637mg, 2.52 mm 〇j? Printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs) dissolved in CH2Ci2 (2 OmL) and cooled this solution to 0 ° C 'then added DMAP (a few crystals) and triethylamine (442 # L). MsCJ (387 # L) was then added and the reaction was stirred at 0 ° C for 2 hours. The volatiles were removed and the residue was distributed in ether and water. The organic layer was washed with saturated bicarbonate, brine and water and dried. Concentration in vacuo gave 88 lmg of crude mesylate. 1 HN MR (300MHz, CDC13): &lt; 5 A paper size is applicable to China National Standards (CNS) A4 specification (21〇X297) 茏 -319-A7 B7 426663 V. Description of the invention (1 2 3 4 5π ) 6. 8 7-6. 84 (lH, s); 6. 0 0-5. 85 (lH, m, — CH =, allyl) 5. 4 0-5. 25 (2H, m, = CH2—, allyl); 4. 72 (lH, dd, J = 3. 9 * 8.5 Hz); 4. 32 (IH-bt &gt; J = 3.9 Hz); 4.3 0-4. 15 (211, 111, mono (: ^ 12-, allyl); 3. 7 7 (3 H-s): 3. 14 (3H, s); 2. 95 (lH, dd, J = 5. 7 '18. 6 H z) (Please read the precautions on the back before ^ ½ page). Binding. Printed by the Consumers' Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs 1 38 (lH, dd, J = 6. 7, 18. 6Hz) 2

O3 This crude mesylate was dissolved in anhydrous THF (20 mL) and treated with Pii3P (727 mg). After stirring at room temperature for 3 hours, water (15 mL) and solid NaHC03 (1.35 g) were added, and the mixture was stirred at room temperature overnight. It was then concentrated in vacuo and the residue was distributed between Et OA c, saturated bicarbonate and brine. The organic layer was separated and dried over MgS. After concentration in vacuo, the residue was subjected to flash chromatography to give aziridine 4,170 mg (33%) as a pale yellow oil * 4 1 H NMR (300 MHz · CDC 1 3) δ 5 82-6. 8 0 (1 H · m); This paper ¥ _ scale applies to Chinese National Standard (CNS _) __ A4 specification (210X297 cm) '~' -320-426663 V. Description of invention (3! 8) A7 B7 .0 4-5. 85 (lH , M C h allyl) 5. 3 5-5. 20 (2H, m CH 2, allyl) 4. 39 (lH, bd, J = 2. 4 Η z); 4. 2 0-4 05 (2H, m C Η 2 -allyl) 3. 7 3 (3 Η &gt;s); 2. 9 0-2. 80 (lH &gt; bd &gt; J = 18. 9 H z; 2. 6 5-2. 4 0 (2 H &gt; m). (Please read the precautions on the back before ^ 1 on this page) • Packing. Example N-Ethyl aziridine 5: aziridine 4 (170 mg , 0.814mmoJ2) was dissolved in CH2CiZ2 (2mL) and pyridine (4mL) and cooled to 0 ° C. Then, acetamidine chloride (87mL) was added and stirred at 0 ° C for 1 hour. The volatiles were removed in vacuum to leave residue The material was distributed in ethyl acetate, saturated bicarbonate and brine. The organic layer was separated, dried over MgS04, and concentrated to give a crude 5,196 mg (96%), which was used directly without purification. 1 H NMR (300MHz, CDC13): 5 6, 8 8-6. 8 6 (1 Η-m); 6. 0 0-5. 85 (lH, m, — CH =, allyl),? Τ Printed by the China Consumers' Standards Cooperative Bureau of the Ministry of Online Economy

4 0-5. 2 0 (2 H m

CH Allyl) This paper size is applicable to Chinese National Standard (CNS) A4 (2I0X 297 mm) -321-4 2 β6 6 3, μ __Β7 V. Description of the invention (319) Printed by the Consumers' Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs T 4 4 5-4 4 0 (1 Η 1 m) i 4 1 6 (2 Η 9 d 1 J = 6 0 HZ »a c Η 2- —, 丙基 • propyl) 3 7 6 (3 Η» s), 3 • 0 0 — 2 9 5 (2 Η &gt; m) t 2 • 6 5 (1 Η 9 bdt J = 1 8 * 5 Hz) I 2-1 4 (3 Η 1 s) 0 Example 6 Azide allyl ether 6; Let aziridine 5 (2 1 9 mg 0 8 7 3 mm 0 il) »Azide pin (4 2 6 ms) and ammonium chloride (4 4 4 m 8) in No 7fVf in water D MF (7 ml) in 9 under nitrogen, heating iSB at 65 ° C, m 0 0 Pour the reaction mixture into saturated bicarbonate / brine> Extract several times with ether 0 Combine the ether layers y Dry the JFTs after washing with brine. / ΡΤί after concentration and flash chromatography (only E t 0 A c) to give azamine 7 7 m S (35%) t dissolved in C Η a C: il z (1 m L) and H Bipyridine c 1 m L) »Cool to 0 ° C 0 Add acetamyl chloride (3 8 β L), and then add cn solid Na a Η C 0 3 after 5 5 minutes, remove the volatiles under vacuum to make residues The material was distributed between E t 0 A c and brine. The organic layer was dried over M g S 0 4 and concentrated in vacuo. Flash chromatography (: using only E t 〇A c) gives 6 (9 9%) of 90 m S ο 1 Η N MR (50 0 Μ Η Z &gt; c DC 1 a): δ 6 8 6 (1 Η »bt IJ = 2 2 Η Z) t 5 9 5 — 5 8 2 (1 Η 9 m &gt; C Η =:, allyl); 5 6 8 (1 Η I bd J 7 3 Η Z) t (CNS) Λ4 specification (2ί〇Χ 297 mm) (Please read the notes on the back before writing this page} -322-Printed by the Consumers ’Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs 4266 6 3 ^ Α7 ___ Β7 ___ V. Description of the invention (32) 5. 35-5. 20 (2H, m = CH2, allyl); 4. 58-4. 52 ClH &gt;m); 4. 2 2-4. 10 (2 Η * m); 4. 04 (lH, dd, J = 5.9 '12. 5 H z): 3. 7 7 (3 H-s); 3. 5 4-3. 52 (lH, m); 2. 89 (lH, dd, J = 5. 9 * 17. 6 H z); 2. 3 2-2. 22 (lH, m); 2. 0 6 (3 H-s) 〇 Example 7 stack Azadiol 7: A solution of olefin 6 (90 mg, 0.306 mm) in acetone (3 mL) and water (258 kernels L), and N-methylmorpholine-N-oxide (3 9 mg) and 〇〇〇 04 (73iiL of 2.5% w / w third butanol solution) and then let this reaction It was stirred at room temperature for 3 days. Add solid sodium bisulfite * and stir for 20 minutes, then filter through a pad of diatomaceous earth and wash it with a sufficient amount of acetone. After concentration in vacuo, flash chromatography (10% MeOH / CH2CJ? 2) was used to obtain diol 7, 50 mg (50%). 0 1 H NMR (300 MHz-CD3CN): δ 6. 8 0-6. 7 0 (1 Η * m): 4. 20-4. 15 (lH, bm); 3. 9 5-3. 80 (lH, m); This paper size applies to China National Standard (CNS) A4 (210X297 mm) ) (Please read the precautions on the back of the page before the # page)-binding. Order -323-Printed by the Shellfish Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs 4266 6 3, A7 B7 V. Description of the invention (321) 3-8 0 1 3-2 5 (6 Η »ΤΠ) t 3-7 0 C 3 Η 9 S) 3 1 0 (1 Η, b S) * 2 8 5 (1 Η» b S) r 2-8 5 — 2 -7 5 (1 Η m) 2-3 0 — 2-1 5 (1 Η ym) * τ 2 1 6 (1 Η 1 b S) t 1 9 2 (3 Η »S) 〇 Example 8 Amino acid Diol 8: Diol 7 (23 m ε * 0-0 7 m 1X1 0) was treated with κ 0 Η aqueous solution (2 2 3 β L 9 0 * 4 0 Μ) at Τ Η F (1 m L) Solution 〇 Stir 1 * 5 hours later 9 Use Amber 1 ite IR-1 20 (plus) The resin acidified the reaction mixture to P Η = 4 ο The resin was filtered off, washed with M e 0 〇, concentrated in vacuo to obtain the crude carboxylic acid *, and dissolved in ethanol (1.5 ΪΪ 1 L). Added to this solution Li ndlar's catalyst (: 20 mg) &gt; Stir for 20 hours in an air atmosphere (1 atm * via a balloon) 〇 Reverse taurine should be filtered through a celite pad &gt; Wash with hot ethanol and water 0 Under vacuum Ethanol removal »The resulting aqueous layer was freeze-dried to give the desired mixture of amino acid 8 and starting azide 7: Compound 9 which is a colored powder. Compound 8; 1 Ν Ν Μ R (50 0 Μ Η z * D 2c &gt;): δ (Please read the notes on the back before filling in this page) Binding-Binding -324-A7 B7 426663 V. Description of the Invention (322) 2. 9 6 — 2. 9 0 (1 Η &gt; m): 2.5 8-2, 5 0 (1 Η, complex) 2. 1 2 (3 Η »S) 0 Window Example 9 Compound 62: Crotonic acid (60 g), cyclohexanone (1 60 mL) Dea with a suspension of toluenesulfonic acid (600 mg) in benzene (450 mL). The n-St ark device was refluxed for 14 hours. After the reaction mixture was cooled to room temperature, a saturated NaHC03 solution (150 mL) was poured. The aqueous layer was extracted 3 times with CH2C. The organic layers were combined, washed with water (2 times), brine (1 time), dried over Na 2 SO 4 and concentrated to give a white solid, which was recrystallized from ether (75 g, 95% 1 Η NMR (CDC 1 a) 8 4. 7 3 (dd-J = 6. 1 * 2. 5Hz, lH); (Please read the precautions on the back before reading and writing this page). Printed by the staff of the Central Standards Bureau of the Ministry of Economic Affairs, printed by a cooperative -325-4 2 6 6 6 3 at ___ 身 _ B7__ V. Description of the invention (323) Example 1 η Compound 63: Lactone 62 (12.7 g * 50 mmoJ2) was dissolved in methanol (30 mL), and sodium methoxide (2 7 g &gt; 5 Ommo J2) was added. The mixture was stirred at room temperature for 3 hours, and the reaction was interrupted with acetic acid (3mL) for 10 minutes. The reaction mixture was poured into a saturated NH4Ci solution (300mL), and CH2C $ Extract three times. Combine the organic layers, wash once with brine, dry MgS04. Purify by flash column chromatography (hexane / E t OAc = 1/1 to 1/2) to obtain the diol (1 1.5 g, 80% ) Starting with g 2% ο XU 3 1ί CDC / IV RΜ Ν Η 4 4 ddd 7 4 5 Z Η 5

H m / IV 1 1

\ ly H Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs msdmd ✓fv / IV / IV vfN ΓΝ 8 5 7 7 0 9 4 4 2 1 2 9 1 1 Examples H, ι-H, Η z 3, H * ) 3 s H. (1 4 i—I,, 8 z 8 H 3 3 1 &gt; 1 VJ) oo \] y II HHH HJ 1 1 J 2, m (6 2) H o 1 3 g 6 3 alcohol 2 3 from C to C plus C times PI will}: ΟΛ 4 6 materials combined οmm goo one standard one standard I country country use lit / one S rule sheet paper one book-¥ public 7 29 4266 6 3, A7 B7 Printed by the Central Standards Bureau of the Ministry of Economic Affairs of the Consumers ’Cooperative on the Five Inventions (324) * 3 9 mm 0 il) Molecular sieves (3 A 9 2 2 S) and pyridine (1 1 g) at C Η 2 c 9. 2 (1 5 m L). Stir the mixture at room temperature for 2 6 hours. ♦ Dilute with ether (30 m L). 0 Filter the suspension through a pad of diatomaceous earth and wash with ether (2 X 2 0 m L). D Combine the ether. Layers> Washed with brine (2 X), dried and concentrated with M gs 0 4 and then purified by flash column chromatography (hexane / E t 0 A c = 3/1) t purification to obtain ketones (0 • 6 9 0 g &gt; 6 7%) 1 Η N MR (CDC 1 3) δ 6 8 4 (d J = 2 * 8 Η Zn 1 Η) 4 * 6 9 (ddd J 6 * 4 4 9 1 6 Η ZZ, 1 Η) • 4 3 0 (d J = 5-0 Η ZO 1 Η) 3 8 6 (s »3 Η) 3 4 5 (d * J = 2 2 3 Η Z * 1 Η) ♦ 2 * 8 6 (mi 1 Η) I 1 • 6 9 — 1 * 3 4 (mt 1 0 Η) ο Example 1 2 Compound 2 8; Add Ν Β Η 4 to ketone 6 4 (0 in 0 ° C »30 minutes -6 3 0 g 1 2-4 mm 〇 9.) Μ e 0 Η (1 2 m L) Solution 0 Let the mixture stir at 0 ° c After 15 hours, the reaction was interrupted with 15 m L of saturated N Η α and the solution was extracted. This solution was extracted three times with C Η 2 C β 2 * The organic extracts were combined with M g S 0 4 on a paper scale. (CNS) A4 grid (210X297 mm) Please read the notes on the back before loading S3. Page -327-Α7 Β7 4 266 6 3 Λ 5. Description of the invention (325) Purification by flash column chromatography (hexane / E t OA c = 2 / l) yielded alcohol (0.614 g, 97%): 1 H NMR (CDC 13) &lt; 5 6. 9 4 (d-J = 0.5 Hz, lH), 4.64 (ddd-J = 9. 8 &gt; 6. 7, 3, 2 H z &gt; 1 H)-4. 55 (dd &gt; J = 7. 1 &gt; 4. 2Hz, lH), 4. 0 6 (m-1 H) * 3. 7 7 (s * 3 H), 3. 04 (dd »J = 16. 5, 2.1 Hz, 1H) Please click on the back Note again

2. 7 3 (d 1. 9 4 (m J = 1 0. 2 H z 1 H),

Ordered by the Consumer Cooperatives of the Central Bureau of Standards of the Ministry of Economic Affairs to print 1, 6 5-1-2 9 (m &gt; 1 0 H). Example 13 Compound 66: Alcohol 28 (2.93 g-10.9 mmoj?) And toluenesulfonic acid (1.5 g) were dissolved in acetone (75 mL), and the mixture was stirred at room temperature for 15 hours. The reaction was interrupted with water (30 mL), and concentrated to pH = 9 with NH 3-20, and the acetone was removed under reduced pressure. The aqueous layer was extracted 3 times with CH 2 C 2 2. The organic extracts were combined, washed once with brine, and dried over Na 2 SO 4. After concentrating, the expected product is obtained: 1 H NMR (CDC 13) δ 7. 0 1 (m * 1 Η), 4. 7 3 (m-1 Η). 210X297 mm) Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs 4 266 6 3 ^ at

A _ B7 V. Description of the invention (326) 4. 4 2 (m * 1 Η), 3. 97 (m &gt; 1 Η), 3. 7 6 (s, 3 Η 〇, 2. 7 1-2 27 (m-2 Η), 2. 〇 2 (s-3 Η), 1. 9 8 (s-3 Η). 眚 Example 1 4 Compound 67: Pyridine (4.4 m at 0 ° C) L &gt; 54.5 mm032) was added to a solution of alcohol 66 (10.9 mm05) in CH2C6OmL), followed by trimethylacetamidine chloride (2.7 m L-2 1.8 mmoJ?). The mixture was allowed to warm to room temperature and stirred for 14 hours, then diluted with CH2C, washed twice with water, once with brine, and dried over Mg S 04. Purification by flash column chromatography (hexane / Et〇Ac = 9 / l) yields the diester (2.320 g -68%): 1 H NMR (CDC13) δ 6. 7 2 (m * 1 Η), 5. 04 (m, lH), 4. 7 6 (m * 1 Η), 4. 4 0 (m, lH), 3. 7 7 (s-3 H), 2. 7 2-2 49 (m, 2H), 1. 3 7 (s-3 H), 1. 3 5 (s-3 H), 1 · 2 3 (s, 9 H). Example 1 5 Compound 68: diester 67 (2. 32g, this paper size applies to China National Broadcasting Standard (CNS) A4 specification (210X297 mm) I ---------- ^ ----- -1T ------ ^. (Please read the precautions on the back before writing this page) -329-4 2 66 6 3 A7 夂 B7 Printed by the Staff Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs (327) 1 1 2 3 mm Ο SI) dissolved in acetone / water (1/1 »1 0 0 m L) 1 1 and heated at 5 5 ° c for 16 hours 9 remove solvent» add water (2 x 5 〇1 1 m L) and evaporate to dry 0 fTfttT toluene (2 X 50 m L) — the same concentration as the mountain — ϋ 1 please 1 (first 1 alcohol 9 direct use of Art m required-~ · step purification 1 1 1 Η N MR (CDC 1 3) 1 of δ Note 1 6 • 8 3 (m 1 Η) 5 • 0 6 (m 1 1 Η), meaning 1 item 1 4 * 4 2 (m * 1 Η) 4 0 g (τη »1 Η), pounds; &gt; ι 3 7 7 (s 3 Η) horse '· this page 1 2 6 8 — 2 4 1 (m 2 Η) 1 1 1 2 2 (s 9 Η) 〇1 1 i Order example 1 6 1 I Compound 6 9: Triethylamine (0 • 8 3 m L at 0 ° c , 1 1 I 6 0 mm 0 il) to diol 6 8 (0 • 4 1 0 gy 1 I 1 5 mm 0 il) in T Η F (8 m L) solution 9 and then slowly add 1 &gt; Liang Jia Thiochlorine (0 • 3 3 m L &gt; 4 • 5 mm 0) ο Warm the mixture 1 1 to room temperature and stir for 3 hours. 0 Dilute with C Η C 3 and wash with water 1 times »Wash with brine ~ Times »Μ g S 0 4 drying * flash column chromatography (hexane 1 I courtyard / Ε t 0 A c = 5/1) purification yields an outward / inward mixture (1 1 0-4 3 0 S» 9 0% ); 1 i 1 Η N MR (CDC 1 3) δ [1 6 8 g — 6 • 8 5 (m 1 1 Η)) (| 5 • 4 8 — 4 • 8 4 (m, 3 Η) 9 1 1 | 3 * 8 0 3-7 8 (s 3 Η) S 1 1 This paper size applies to Chinese National Standard (CNS) Λ4 specification (21 OX 297 male C) A7 B7 2 Η) 9 Η)

(S printed by the Consumer Cooperatives of the Central Bureau of Standards of the Ministry of Economy 426663. V. Description of the invention (328) 2. 9 0-2. 6 1. 2.5 5, 1.1 Example 1. 7 Compound 70: Lingshuo 69 (0. A mixture of 4 0 g (1.3 mm) and sodium azide (0.410 g, 6.29 mm) in DMF (10 mL) was stirred for 20 hours. The reaction mixture was then diluted with ethyl acetate to saturate NHAC i ? Solution, washed with water and brine, dried over MgSO 4. Concentrated to give azide (0.338 g &gt; 90%): 1 H NMR (CDC 13) δ 6. 78 (m, lH), 5 . 3 2 (m-1 Η), 4. 2 0 (m &gt; 1 Η), 3. 8 9 (m &gt; 1 H), 3. 7 8 (s-3 H), 3. 0 0- 2. 6 0 (m * 2 H), 1 2 1 (s, 9 H). Example 1 8 Compound 71: Triethylamine (0.4 mL, 2. 9 mmoj?) Was added to the alcohol 70 ( 0. 338g, 1. ImmoJ?) In CH2Cj? 2 (llmL ·) solution, and then slowly add methanesulfonyl chloride (0. 18mL, 2.3mmoj?). This mixture was stirred at 0 ° C for 30 minutes to Diluted with CH2CJ? 2, washed the organic layer twice with water, then washed with brine, and dried with Mg S 04. Quickly this paper size is applicable to the Chinese national standard (CNS) Λ4 now (2! 0X297 (Li) ---------- ^ ------ 1 Order ------ I (Please read the precautions on the back before reading &quot; 'This page) -331-4 2 6 6 6 3 λ Α7 'Β7 Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs * 5 Description of invention (329) Column chromatography (hexane / Et 0 AC = 3/1) Purified to the expected compound (0 3 8 0 s, 8 2%) '1 Η Ν Μ R (c DC 1 3) &lt; 5 6 8 2 (m 9 1 H 0 5 4 4 (m 9 1 Η) »4 7 6 (dd J = 7 3 * 1 * 4 Ζ zi i 1 Η) »4 4 8 (m 1 H) 3 8 0 (S» 3 Η) &gt; 3 1 1 (sy 3 H) 2 8 2 — 2 6 1 (m 2 Η) 9 1-2 1 (s »9 H) 0 K Example 1 9 Compound 7 2: Let azide 7 1 (0-3 8 0 g» 0 9 4 mm 0 Si) and triphenylphosphine (0 • 2 7 1 S t 1-0 4 mm 0 il) in T Η F (1 9 m L) and stir for 2 hours ο react with water (1 '9 m L) and diethylamine (0 * 3 9 ΓΪ1 L 2 8 2 mm 0) Interrupt r and stir for another 4 hours 〇Removal of the solvent under reduced pressure 1 The mixture was directly used in the next step. 〇 Pyridine (0 6 8 m L i 8 4 ΤΠ m 0) was added to the above mixture at C Η 2 C ί 2 (2 0 m L ) Of solution 9 and then slowly add acetyl chloride (0 3 0 m L t 4 2 mm 0 again). 0 Allow the mixture to stir at 0 ° C for 5 minutes. Dilute with ethyl acetate. Wash the mixture twice with water.) Rinse with brine. Once 9 dried with M s S 0 4. Flash column chromatography (hexane // E t 0 A c = 3/1) aziridine (0-2 0 5 S »8 3%) after purification: 4266 6 3 Λ employee of the Central Standards Bureau of the Ministry of Economic Affairs Printed by the Consumer Cooperative V. Description of the invention (330)! 1 Η Ν Μ R (c D c 1 3) δ I ί 7 1 9 (χΪ1 t 1 H) »5 5 8 (m &gt; 1 Η) &gt; 1 1 I 3 7 7 (S 9 3 H) 9 3 1 4 (m »2 Η) 9 1 I please 1 j 2 8 5 (dd 1 J = 7. 0 9 1 6 Η ζ 1 Η), Xianjian II Read 1 1 2 3 4 (m »1 H) &gt; 2 1 6 (s 3 Η)! Back 1 1 of 1 1 1 4 (s» 9 H) ο pay attention to ancient 1 I Ψ item I 1 example 2 〇 page Compound 7 3: Let aziridine 7 2 (0 in 2 0 0 s 9 [[0 6 8 mm 0 st) &gt; sodium azide (0 • 2 2 1 S 9 1 I 3 4 mm 0) with chlorine Ammonium chloride (0 * 1 4 6 g »1 1 2 7 mm 0 9.) in D Μ F (1 0 m L ) Stir the mixture at room temperature for 14 hours 0 and then dilute the mixture with ethyl acetate, 1 1 wash five times with water »brine wash-then dry with M g S 0 4 &lt; = quick column 1 Chromatography (hexane / Et 0 A c 2/1) purification gave the expected product 1 line and desacetylamine (0 1 39%) 〇 This mixture was dissolved in acetic anhydride I (2 τη L) And stirred for 2 hours. 0 m of acid anhydride was removed under reduced pressure to give 1 1 I expected product (149 mg): 1 1 Ι 1 Η N MR (CDC 1 3) δ 1 i 6 7 6 (m &gt; 1 H) i 1 5 5 3 (d »J = 8 • 5 Η Z 1 Η)» 1 5 0 5 (m »1 H) 9 4 * 3 1 (m» 1 Η) 1 1 I 4 0 8 (m, 1 H) 3 7 9 (s 3 Η) I 1 I 2 9 1 (m * 1 H) f 2 5 1 (m 1 Η) 1 1 1 This paper ruler; 1 Applicable to Chinese national standards &lt; CNS) A4 specification (210 × 297 male t) -333-A7 B7 V. Description of the invention (33i) 1 9 9 (s &gt; 3 H) »1 2 0 (s 9 H)« Example 2 1 Compound 7 4; A solution of K 0 Η Μ e 0 Η / H zi 〇 (0 5 Μ t 4 4 m L 2 • 2 mm 0%) was added to ester 7 3 (1 4 9 ms · »0 4 4 mm 〇 il) 9 Let the mixture stir at room temperature for 3 hours f and then cool to 0 ° C * Acidified with Ambe r 1 ite (acid) to P Η 3-4 0 The mixture was filtered and washed with M e 0 Η, then concentrated Carboxylic acid 9 is obtained as a white solid c 7 3 m S 6 9%) * 1 Η N MR (CD 3〇D) δ 6 6 2 cm, 1 H) 1 4 • 1 5 (m 9 1 Η ) &gt; 3 9 5-3 • 7 2 (mt 2 Η) 2 8 4 (dd »J = 6-7 * 1 * 4 H z 9 1 Η), 2 2 3 (mt 1 H) ψ 1 9 9 (s 9 3 Η) β Example 2 2 Compound 75 printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs: a mixture of azide 74 (8 mg) and Pd_C (Linlar) C 1 5 mg) in ethanol (2 mL) in hydrogen Stir for 16 hours. The mixture was filtered through a celite pad and washed with hot MeOH_H20 (1/1). Concentrated to give a solid. This solid was dissolved in water, passed into a short C-8 column, washed with water, and concentrated to give a white solid (6mg): NMR (D 2〇) «5 6. 2 8 (m &gt; 1 Η) ， —This paper scale IT Finance Guan Jia Pi (CNS) _ grid (21GX297 male thin ~ -334-4266 6 3, A7 _B7_ V. Description of the invention (332) 4. 06-3. 85 (m-3H)-2 8 3 (dd-J = 1 7 .7, 5. 4 H z · 1 H), 2. 3 5 (m · 1 H) &gt; 2.06 (s · 3 H). Example 2 3 Compound 76: Dissolve carboxylic acid 74 (68 mg, 0.2 8 mmoj?) And diphenyldiazomethane (61 mg, 0.31 mmoJ?) In ethanol (12 mL) and stir for 16 hours. The reaction was performed with acetic acid (0 5mL) was interrupted and stirred for another 10 minutes. The solvent was removed under reduced pressure and purified by flash column chromatography (Et OAc) to give the ester (56mg, 50%); 1 H NMR (CD3OD) δ 7 36-7-23 (m, 10H), 6.88 (s, 1H), 6.7.6 (s · 1H), 4.2.1 (m1H), 3-93-3. 79 (m, 2H), 2. 89 (dd, J = 17 · 8 * 5. 0 H z * 1 H) printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs, 2. 3 4 (m-1 H), 2 0 0 (s-3 H). Example 2 4 Compound 77: Pyridine 40aL, 0.5 mm 0 i?) Was added to a solution of alcohol 7 6 (20 mg, 0.05 mm iZ) in c H 2 c lmL), followed by acetic anhydride (this paper is suitable for the Chinese National Standard (CNS) ) A4 specification (210X297) 煃 -335-4266 6 3, V. Description of the invention (333) A7 B7 Printed by the staff of the Central Standards Bureau of the Ministry of Economic Affairs, printed by the cooperative 2 2 β L 9 0 2 5 mm 0 32 hours »Decompression Solvents and reagents were removed. E t 0 AC = 1/2) Purified); 1 Η Ν Μ: RC 'CD 丨 c 1 3,) δ 7 4 0 — 7 2 7 (m, 6 • 9 5 ( s ♦ 1 H), 6 5 6 0 (m 1 H) 5 1 2 (ddd 9 J = 1 Η Z 9 1 Η) »4 2 8 (dd * J = 2 0) 4 * 1 5 (m &gt; 1 H) »2 • 9 3 (dd 1 J = 17» 2 • 5 7 (m 9 1 H) &gt; 2 * 0 9 (s &gt; 3 H), 2 Example 2 5 Compound 7 8 Ring Monoester 7 7 0 * 0 4 5 mm 0) »Fennel 0 * 4 5 mm 0 J2) and T FA 1 ml L) Stir 2 mixture 〇 agent 〇 flash column chromatography (E t 0 A 1 0 0/1) Purified to obtain carboxylic acid 1 Η N Μ R (c DC 1 3) t (CNS) A4 size (210X297 mm)]. This mixture was allowed to stir for 24 small flash column chromatography (hexane / diester (20mg, 91% 1 0 ，), .8 7 Cm * 1 Η), 6. 4 * 10.2, 5.9.9. 0, 9. 4Ηζ, 1Η) .8 * 5. 2 Η ζ * 1 Η) .0 1 (s, 3 Η). (2 0 mg-Charm (5 0 # L, (lmL) in CH2Cj22 (min. Remove solvent and test under reduced pressure to EtOAc / AcOH (6 mg): -336-Printed by the Consumers Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs system

Zl 2 6 6 6 3 Λ A7 __B7_ V. Description of the invention (334) 6. 8 5 (m-1 Η), 5. 5 4 (m-1 Η), 5. 1 2 (m, 1 Η), 4 3 1-4. 03 (m-2 Η), 2. 8 9 (m, 1 Η), 2. 6 0-2. 41 (m-1 Η), 2.11 (s, 3H), 2.03 (s , 3H). Example 2 6 Compound 79: Azide 78 (6 mg, 0.02 mmoJ?) And Pd-C (L ind 1 ar) (15 mg) in EtOH / H20 (2.2 mL, 10 / l) The mixture was stirred under hydrogen for 3 hours. The mixture was filtered through a celite pad and washed with hot MeOH / H20 (1/1). Evaporate to obtain a white solid, dissolve it in water, and pass through a C-8 column. Evaporate the water to obtain a white powder (3 mg): 1 Η NMR (D 2 Ο) δ 6. 3 2 (m * 1 Η ), 5. 0 6 (m-1 Η), 4. 0 6 (t * J = 10. 4 Η ζ &gt; 1 Η), 3. 8 4 (m-1 Η)-2. 8 3 ( m &gt; 1 Η), 2. 4 2 (m * 1 Η), 2. 06 (s, 3H), 2. 0 0 (s, 3 Η). Example 2 7 Compound 80: DCC (35mg, this paper size applies Chinese National Standard (CNS) Λ4 specification (210X297mm)

---------- i ------ ΐτ ------ Gland, J (Please read the notes on the back before filling this page) I -337-4 266 6 3 Λ Β7 Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs. 5. Description of the invention (335) 0 1 7 2 mm 0 5) Added to alcohol 7 6 (3 5 mg 0 0 8 6 mm 0 ί) 1 Bo c — Glycine ( 30 ms 0 1 7 2 mm 0 9.) and a catalytic amount of D Μ AP in CH 2 c β 2 (1 m L) ο make the mixture stirred for 30 minutes through y filter and C Η c 9. 3Cleaning> The resulting CHC) 2a solution was washed twice with water ο concentrated to give a white solid 9 flash column chromatography (Kiyuan / E t ο A c = 1/2) purified to obtain the product (30 mg) 1 Η N MR (c DC 1 3) δ 7 3 9 — 7-2 6 (τη 1 1 0 Η) 6 * 9 5 (S * 1 Η), 6 8 6 (m ί 1 H) 5 7 7 ( m 1 Η), 5 * 2 7 (mt 1 H) J 4 9 9. (m 1 Η) * 4 • 1 8 to 4 * 0 1 (m »2 Η)» 3 9 4 to 3 • 8 4 ( m »2 Η) t 2 * 9 6 (dd &gt; J = 7. 8 9 5 9 h Z &gt; 1 H) »2-5 7 (m» 1 Η), 2 * 0 2 (s 3 H) 1 * 4 5 (s 9 9)) 〇 Example 2 8 Compound 8 1: Let diester 8 0 (30 m 8 9 0 5 mm 0) * Anisyl ether (150 μL) and τ FA (1 m L) in CH 2 C Stir the mixture in 9.2 (1 ml) for 3 hours. 0 Evaporate the solvent and reagents. Ο Dissolve the mixture in water and wash it with C Η C 5 3 three times. A white solid was obtained after the water layer was evaporated to dryness. The paper size is in accordance with Chinese National Standard (CNS) Λ4 specification (2 丨 0x297 mm) -338-426663 Μ Α7 ___ Β7_ V. Description of the invention (336) 1 5 mg): XH NMR (CD3〇D) 5 6. 7 3 (m ♦ 1 H), 5. 2 5 — 5. 15 (. M'lH) '4. 35 (m, lH)-4. 17 (m, lH) , 3. 8 2 (m · 2 H), 2. 93 (dd, J = 17.7, 5.6 Hz, 1H), 2. 4 2 (m-1 H), 1. 97 (s, 3H). Example 2 9 Compound 82: A mixture of azide 81 (15 mg, 0 ... 0 5mpio J2) and P d — C (Lindlar) (3 Omg) in E t 0H / H20 (4 mL, 1/1) Stir under hydrogen for 3 hours. The reaction mixture was filtered through a celite pad and washed with hot MeOH / H20 (1/1). Concentrated to give a glassy solid, which was dissolved in water and passed through a C-8 column. After the water was distilled off, it was printed by the Consumers' Cooperative of the Central Bureau of Standards of the Ministry of Amino Acids. Printed on paper I a1 1 7 13 V 9 t 9 (mm 3 ms R ((-((M 8 9 8 5 4 N 6 2 o 8 o H 6 4 4 2 2

Η H m m / IN 8 2 Η 1-

Η H m »() 1 H 4 3 Η 1 Pre-broadcasting countries and countries ί 中 一 通 i 公公 3 3 2 6 6 6 3 A7 B7 V. Description of the invention (337) Example 30 0 211 B 〇c guanidine Methyl ester 9 2: treated as described in Kim and Qian, 'Tetrahedron Lett. ^ 3 4: 7 6 7 7 (1 9 9 3). Chlorinophil (46 mg, 0.17 mmo J?) Was added at a time to amine 91 (42 mg 1 0.154 mmoi2), di-Boc thiourea (43 mg, 0.155 mmo 芡) and triethylamine (72 / iL) in a 0 ° C solution of anhydrous DMF (3 100 nL). After 30 minutes, the reaction was allowed to warm to room temperature and stirred for another 2.5 hours. The reaction mixture was filtered through a pad of diatomaceous earth, concentrated, and purified by flash column chromatography (100%, ethyl acetate) to obtain 70 mg (89%). Please read the precautions below before i 2 9 H 1 substance C沬 D bubble c color without R ′ is Μ its Ν 7 3 s Z Η Μ ο ο 3 3) 1 Η 8 o 6 3 8 Λ—y xly zz Η H 00 1X 7 2 = it JJ Η H 1 dt (c -6 H IX d 3 6 H IX d Γ '6 7

8 7 = II TJ TJ z H 4

z H Q Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economy 4 4 2 2 1 7 5 4

J

Complex J / IV Ho 1 1 d 4 (I 7 = m difficult

Nly,; z) Η H o 2 z: H) 4 H 3 7, r ~ H s »(4 9 3 5. II 3 J) HH 1 3-, dsd (-(6 4 7 8 2 I 5 4 s / V 2 9) H 8 1—- s-»(9 H 4 1 ， m; () OH 3 3 This paper size is applicable _ national standard {CNS) Λ4 specification (2 丨 〇'297 mm) 4 2 6 6 6-, A7 __B7_ V. Description of the invention (338) Example 3 1 Di-Boc guanidinocarboxylic acid 93: a solution of ester 92 (70 mg, 0.136 mm) in THF (3 mL) (cooling) To 0 ° C) KOH aqueous solution (350mL, 0.47 6M) was added. Then the reaction was warmed to room temperature and stirred for 2 hours, and then acidified with Amberlite IR-120 (plus) acidic resin to Ρ = 4 5. Filter out the resin, wash with ethanol and water. Concentrate in vacuo to obtain 66 mg (97%) of carboxylic acid 93. It is a white solid. 1 H NMR (CDC13, 300MHz): 5 1 1. 4 0 (brs, lH); 8. 67 (d, lH, J = 7. 8 H z); 6. 8 9 (s, 1 H); 6. 6 9 (br d'lH &gt; J = 8. 4 Hz); 4. 77 (d &gt; lH &gt; J = 7. 2Hz); 4.70 (d, lH, J = 7.2 Hz); 4. 4 0-4. 15 (m &gt; 2 H); 3.3.2 9 (s * 3 H); 2. 84 (dd, lH, J = 4.8, 1) printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs 7. 1 H z): 2. 4 5-2. 3 0 Cm- 1 H); 1. 95 (s, 3H); 1. 4 9 (s-9 H) ·· 1. 4 8 (s, 9 H). Example 3 2 Guanidine carboxylic acid TFA salt 9 4: In dione B oc guanidine carboxylic acid 9 3 (This paper size applies to Chinese National Standard {CNS) A4 specification (2 丨 0 X 297 cm) -341-4266 6 3 , A? B7 Printed by the Shellfish Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs. 5. Description of invention (339) 2 3 m S t 0-O 4 6 mm ο) in CH s: C parent 2 (1 m L) solution ( Add cold trifluoroacetic acid (500 β L) to the cold place (0 to 0 ° C). After 30 minutes, allow the reaction to warm to room temperature and stir for another 1.25 hours. Remove the volatiles under vacuum. The residue was co-evaporated several times with Η 2 ◦ 9 to give a pale orange solid. The residue was purified by reverse-phase cla chromatography with Η 2 0 as the eluent 9 and the fractions containing the expected product were combined and freeze-dried to give 15 mg 9 3 as a white powder 0 1 Η NM MR (D z, | 5 0 0 MHz:): δ 6 8 2 (t, 1 Η t J = 2. 0 Η Zn) &gt; 4-5 1 — 4 * 4 7 (m * 1 Η) t 3-9 3 (dd 1 Η, j = 9-0 1 1 • 2 Hz) 1 3 8 7 — 3 8 0 (seems to be ddd 1 Η) r 2 8 8 C m 1 Η) ♦ 2 • 4 8 — 2 4 5 ( Complex m) 2 0 0 7 (s $ 3 Η) 〇1 3Η MR (E 2) * δ 1 7 6 • 1 * t 1 7 0-0: 1 5 7 1 1 1 3 9 .2; 1 2 9 5 6 9 4: 5 6 • 2: 5 0 9, 3 0. 3 1 2 2 • 2 〇 Example 3 Synthesis of 3 1 0 2 * Azid allyl ether 6 (2 4 m S 9 0-0 8 2 mm 0 il) in ethanol (1 m L) solution with Li nd1 ar catalyst treated with hydrogen (1 atm) for 1-5 hours 9 Reaction mixture Standard (CNS) A4 specification (210 X mm) A7 B7 426663 ^ V. Description of the invention (340) Filter through celite pad and wash with hot ethanol. Concentrated in vacuo to obtain a light-colored solid, which was dissolved in T Η F (1-5 m L) 1 Treated with an aqueous solution of K 0 1 (1 1 2 4 6 a L y 0.5 0 Μ) t Stirred at room temperature 2 hours, then 1 I, after 1 1 please use Amb ε; rlite IR-120 (pl us) acid! Acid resin to acidify to P Η = first heard 1 I read 1 4 • 0, filtered with ethanol and H 2〇 Clear; first concentrated in vacuo to get its orange back • it I | solid y purified by C 1 8 column chromatography (H 2 0 stripping) and combined with the note 1 i product fraction, freeze-dried to give 2 : 1 of 1 0 2 and fully saturated matter 1 I • A mixture of 14 t I 1 compound 1 0 3 which is a white powder 0 compound 10 2)) 1 Η NMR data: page sw · 1 1 Η N MR R (D 2, 5 0 0 Μ Η ζ); 6 1 I 7 ten 8 5 (S, 1 Η) 9 1 1 1 4-2 9 cbrdt 1 Η 9 J = 9 * 2 Hz): l order 1 4 1 6 ( dd, 1 Η t J = 1 1 6 t 11 .6 Hz I 1 1); 3 7 8-3.7 2 (mt 2 Η) t 1 i 3 6 2 (seems to be ddd 1 1 Η) 1 1 1 2 9 5 (seems to be dd &gt; 1 H) t holds 5 8-2. 5 2 (m * 1 Η) .; Printed by the Consumer Cooperatives of the China Standards Bureau of the Ministry of Economic Affairs 2. 1 1 (s, 3 Η); 1. 58 (α «2Η · Ι = 7. 3 Η ζ); 0.9l (ti3H, J = 7.3Hz ). Example 3 Synthesis of 4 0. 038mmoi2) solution of water (1.3mL) cooled to 115: Amino acid 114 (10 · 7 m g.

'Λ 2 66 6 3 Λ a? Β7 Printed by the Consumer Standards Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs of the People's Republic of China (341) 0 ° c 9 to 1-0 Μ Ν a 0 Η m rounded to P H = 9 0 and then ~~ Add thiomethylformimine hydrochloride c 2 6 mg, 0 1 5 3 mm 0) r at 10 Μ N a 0 保持 keep P Η = 8 5 to 9 0 let the reaction at 0 — 5 0 C Stir for 3 hours. The residue is concentrated under vacuum. The residue is extracted with water through a C 1 8 column. 0 The fractions containing the product are combined. 9 The product is freeze-dried to give formazanimine carboxylic acid 11 5 (10 mg) as a white powder. 0 1 Η N MR (D 2 0 3 3 0 Μ Η Z, heterogeneous mixture) 7 • 8 3 (S »1 Η) 9 C 6 * 4 6 (S«) & 6 4 3 (S:; The total is 1 Η]; 4 8 3 (d 1 Η, J = 7 3 Η Z) 4 7 3 (d »1 Η &gt; J = 7 3 Η ζ) 4 5 0 — 4 3 5 (m 1 Η) r 4 1 0-4 * 0 5 (τη 1 Η) C 4 • 0 4 — 3 9 5 cm 9) &amp; 3. 8 0 — 3 6 5 (m) 1 Total 1 Η] 3 3 9 (s 3 Η) 2 9 0 — 2 7 5 (m »1 Η) * 2 5 5 — 2 3 0 (τη 1 Η) t C 2 0 3 (S) & 2 domains 0 1 (S), a total of 3 实例 Example 3 5 Compound 1 2 3 Toluene chloride (4.3 g ♦ 2 2 6 mm 0 9.) was added to the alcohol 6 3 ( 5 8 4 2 g 2 0 5 mm 0) and D Μ AP (200m g) pyridine (this paper size applies to Chinese national standards (CNS &gt; Λ4 size (210X297 mm) -344-4 266 6 3 A7 B7 Printed by the Consumers' Cooperatives of the Bureau of Loss of Standards, Ministry of Economic Affairs, V. Invention Description (342) 4 OmL) solution. The mixture was stirred at room temperature for 40 hours, and pyridine was removed under reduced pressure. The reaction was interrupted with water and extracted three times with E t OA c. The organic extracts were combined, washed with water and brine, dried over Mg S 0 4 and purified by flash column chromatography (hexane / E t OA c = 2/1) to obtain p-toluenesulfonate (8.04g, 89% ): 1 Η NMR (CDC 1 a) δ 7. 8 4 (d-J = 8. 3 H z-2 H) * 7. 3 3 (d * J = 8. lHz, 2H), 4. 7 8 (m · 1 H), 4. 4 3 (m-1 H), 4. 06 (m, lH), 3. 79 (s, 3H), 2. 4 4 (s, 3 H), 2. 43 -1. 92 (m &gt; 4H) ♦ 1 6 1-1. 22 (m, 10H). Example 3 fi Compound 124: Pocj? 3 (100 # L, 1.1 mmoi?) Was added to a solution of alcohol 1 23 (440mg, 1.0mmo 芡) in pyridine (3mL). Let the mixture at room temperature Stir for 12 hours under a 'interrupted reaction with saturated NH4C solution. The aqueous layer was extracted three times with ether, the ether layers were combined, washed with water and then washed with 2N HCJ2', and then washed with brine and dried over Mg s 04. Fast column layer (Hexane / E tOAc = 2 / l) after purification, the mixture of the expected product 1 24 and some impurities (35mg, 83%, 2 / l) was obtained. Please read the note of Λ first

I

The page size of the paper is in accordance with the Chinese national standard (CNS 丨 Λ4 specification (210 X 297 mm) 345-4 266 6 3 Λ A7 B7 Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs * 5 Description of invention (343) Example 3 7 Compound 1: Acetone of methyl shikimate (8 7 7 m S »3 • 8 5) with mesylate (3 3 0 β L 9 4 2 3 m m 0 SI) added to -10 ° C mm 〇1 1 ^ Tetrahedron Lett Λ 9 26: 21 (1 985)) in dichloromethane (15 m L) solution * Then triethylamine (6 4 0 β L 9 4. 6 2 m m 0 ) 0 Allow this solution to stir at -10 ° C for 1 hour &gt; and then stir at 0 0C for 2 hours »At this time, add methanesulfonyl chloride (3 0 β L) 9-ethylamine (6 4 β L) 〇1 hour later Add cold water, separate the organic layer 9, wash with water, dry (Mg S 0 4), and evaporate the crude product by silica gel chromatography (1/1 of hexane / ethyl acetate) to obtain methanesulfonic acid as an oil. Ester 1 3 0 (1 1 S 9 3%). The mesylate 1 3 0 (9 9 0 mg 3 2 mm 0 J2) was dissolved in tetrahydrofuran (5 β L) and treated with 1 M Η C Si (5 ml L). The solution was stirred at room temperature for 19 hours, diluted with 5 ml L water and stirred again. Hours. Evaporate the organic solvent to obtain an oily residue and extract it with ethyl acetate. Combine the organic extracts, wash with brine, dry / PTC (MS SS 0 4) and evaporate to dryness. Add CC 2 C 2 to the crude residue. Content »The white solid precipitated by filtration was washed with C Η 2 C 2 to obtain a diol 1 3 1 (32 3 mg, 38%) 0. Let this diol 1 3 1 (2 60 ms • 0.9 8 mm 0 9.) part of the suspension in Τ HF (5 m L) was cooled to 0 ° C, D Β U (1 5 4 β L t &lt; 1 * 0 3 mm ο) was added, and this solution was- Stir at 0 ° C for 3 hours and warm to room temperature for 5 hours. The solvent 1 was distilled off, so that the crude residue was distributed between ethyl acetate (40 m L) and 5% citric acid. The paper size is applicable to the Chinese National Standard (CNS) Λ4 specification (210X29? Public Holiday) -346-Appendix C 426663. Revised Page of Chinese Specification for Patent Application No. 85107487

㈣I is filled with ethyl acetate, ethyl acetate, and then washed with water and salt. The machine has 44) bu 3 () Ming L said ΠΊ Ming ο issued 2 '(five white and 4 for ο its S, s XI / Μ% (ο dry 7 dry The tg layer m machine 7 has 1 and 1 combined with C, the material is extracted from the oxygen extraction} ring L to give m to get 5, 1 dry (. The structure of the steam after the color structure of the preparation method is dedicated to the spectrum of light R Μ Ν Η 1 body Guzhi 83 cases

(4 acid 3 B c gas) Tri-based methyl: oxygen 1 methyl 5 II alcohol GL mgm alcohol protection m m ° c ο to add 5 1 ο ηχ (Please read the precautions on the back before filling this page ) The CH2ce2 (10mL) solution printed by the cooperative is consumed by employees of the Central Standards Bureau of the Ministry of Economic Affairs. After 5 minutes at 0 ° C, it was stirred at room temperature for 1 hour and then evaporated to dryness. The crude product was purified on silica gel (ethyl acetate) to give an alcohol 51 (237 mg, 82%) as an oil: 1 H NMR (300 MHz, CDC13) δ 2. 1 1 (s »3 Η), 2. 4 5 ( m * 1 Η), 2 · 97 (dd, lH'J = 3 '8 * 18. 8)' 3 · 6 6 (m * 2 Η), 3. 7 8 (s * 3 Η), 4 4 0 (brs, lH), 5 · 2 2 (brs »1 H) Window order% b H) Methyl acid 150: Add NaH (60% mineral oil dispersion, s' 0 2〇! 11111〇 &lt; 5) To alcohol 51 (46 8 s) The paper size is suitable for fiscal and national (CNS) A4 specifications (2iGx297 Publication -347-4 2 66 6 3,: A7 B7 V. Description of the invention (345) 0 1 8 mm ο _ 9 .) And a T Η F (0 • 7 m L) solution in a methyl bowl (5 6 β L »0.90 mm 〇. 9.), stir at 0 ° c for 2-5 hours &gt; add Two portions of Na Η (2 mg 0 for 1 hour at 0 ° c »Stir for 4 hours at room temperature 9 Let it cool to 0 ° c 9 Add 5% citric acid (0-5 m L) 〇 Mixture with acetate (4 X 2 m L) extraction, combined organic layers »dried (MSo) and evaporated to dryness) ο crude residue in silica gel (acetic acid Ethyl) was purified as a solid methyl ether 1 ί 5 0 (1 2 m S &gt; 25%): 1 Η N MR (30 0 Μ Η Z t CDC 1 3) &lt; 5 2 0 7 ( S, 3 Η) 9 2-2 3-2. 3 4 (m * 1 Η) 9 2 • 8 9 c seems to be ddd »1 Η)» 3 4 3 (S, 3 Η) 3 * 5 8 (mt 1 Η) 9 3 * 7 8 (S 丨 -3 Η) 4 1 3 (m 9 1 Η) V 4 4 0 (mj '1 Η)) 5 7 3 (d,' 1 Η ί J — 7-6 ) 1 6 8 9 (m, '1 Η) ο Example 4 0 Amino acid 15] Polymer-supported Ph 3f, &lt;: 7 5 mg 3 mm 0 9. P / g resin) was added to the methyl group Ether 1 50 (12 m &gt; 0 • 4 5 m mo)?) In T Η F (1 m L) / Η 20 (100 L) solution. Allow the mixture to stir at room temperature for 19 hours to filter out the resin, wash it several times with THF, combine the filtrate and the washing solution, and evaporate to dry ------------ ______________. This paper size applies to Chinese National Standard (CNS) Λ4 (2 [0 × 297 mm) 348 A7 B7 Printed by Consumer Cooperatives, Central Standards Bureau of the Ministry of Economic Affairs 426663 V. Description of the invention (346) 8 mg of crude residue was taken out and dissolved in THF (0.5 m L) Φ Add 0 5M KOH (132 / iL) / water (250j «L) · Allow this solution to stir at room temperature for 1.25 hours 'adjust the pH to 3-4' with 2 R 1 20 ion exchange resin The resin was stirred with 1M HCj. After filtration, it was treated with 1M HC $ again until no amine was detected in the acidic washing solution (measured by fluorenone trihydrate). The resin washings were combined, and the residue was purified by C-18 reverse-phase silica gel (extracted with water) and freeze-dried to obtain amino acid 1 5 1 (1.8 mg, 15%), which was a white solid: 1H NMR (300MHz, D20) 5 2. 0 9 (s, 3 Η), 2.48 — 2.59 (seems to be mouth 1 ;, 111) '2. 94 (dd, lH, J = 5. 7 * 17. 4) 3 6 1 (m, 1 Η), 4. 14-4. 2 6 (m * 2 Η), 6. 8 6 (brs, 1H). Tube Example 4 1 Amino acid allyl ether 1 5 3: Polystyrene-supported PP h3 (50mg) was added to azide 6 (16mg, 0,054mmoJ?) Butane HF (0.5mL &gt; / H20 ( 3 5 ML) solution. The reaction was allowed to stir at room temperature for 24 hours, filtered through a sintered glass funnel, washed with hot methanol and concentrated in vacuo to obtain the crude amino acid ester, which was dissolved in THF (1.0 m L) , KOH water-soluble, Zhang scale applies Chinese National Standard (CNS) A4 specifications (2l0x29: 7 mm) (Please read the precautions on the back before filling this page)

-349-4 2 6 6 6 3 Λ Α7 Λ Β7 Printed by the Consumers' Cooperative of the Economic Standards Bureau of the Central Bureau of Standards and Technology. 5 • Description of the invention (347) I | liquid (2 2 0 β L «0 5 Μ) processing. In the room: search for 2 hours at warm temperature. After 1 1 I add Ambe ΪΓ: ite IR-1 20 (plus) acid. Resin until solution! 1 P Η = 4 5 Filter out resin with ethanol and Η 2 0 Cleaning. Concentrated in vacuum S 1 I Please shrink 1 I to obtain a light orange solid Mtfft body &gt; Purified by reverse phase C 1 I Chromatography ; Freeze-dried to give white powder of amine back 1 1 1 acid 1 Η Ν Μ R (D 203 0 0 Μ Η z): δ Note 1 I 6 * 5 1 (brtt 1 Η) »item I 6 • 0 5 — 5 • 8 0 (m 1 Η, 1 C Η =, allyl) transcription, book) 5 pages 1-3 6 — 5-2 4 (m 9 2 Η 9 = C Η 2 , Allyl 1) 1 4 3 5-4 * 2 5 (m V 1 Η)! 1 4 • 2 5 — 4 0 5 (m 2 Η, — C Η 2-, allyl 1 1) * 4 -0 2 — 3 9 5 (m 9 1 Η) t order I 3 • 8 1-3 7 0 (m 9 1 Η) 1 I 2 * 8 6 — 2-7 7 (seems to be dd 1 Η); 1 J | 2 3 5 —— 2 2 4 (complex m, 1 Η) t 1 1. Like 2 * 0 9 (S * 3 Η) 〇f 1 Example 4 2 1 1 ί epoxide 1 6 1 = olefin with M c P BA C 6 9 0 m g) added to f 1 0 ° C 1 6 0 (5 3 2 m S, 1 * 6 1 mm 〇 ^, real 1 I Example 14 Preparation of 卞 Before use, the crude mesylate was passed through silica gel with 30% 1 1 1 E t 0 AC / hexane ija, filtered) in dichloromethane (1 5 ra L) solution β 1 1 order This mixture was warmed to room temperature and stirred overnight. Remove the solvent under vacuum, and then dilute with 1 ethyl acetate. Organic layer with sodium bisulfate aqueous solution, saturated hydrogen carbonate. 6 3 Shoulder-A7 B7 V. Description of the invention (348) Salt, brine washing, Mg S 04 drying, vacuum concentration * The residue was purified by flash column chromatography (30% hexane / ethyl acetate) 161 (437mg, 78%) 1 H NMR (CDC13 * 300MHz) as a light oil:

Cl: 1 non-mirror stereoisomer mixture] 5 [4. 7 5 (dd * J = 3.9, 8. 2 Η z) &amp; 4. 7 1 (dd &gt; J = 3. 9 * 8. 4 H z), the total is 1H]; 4. 3 7 (m · 1 H); 4. 2 5-4. 0 0 (m * 2 H); 3. 7 8 (s &gt; 3 H); please read Note on the page printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs on this page C 3 6 8 (dd 1 J = 3 5 1 C dds J = 6 Η * C 3 1 7 (s) &amp; 3 C 2 9 9 ( m) &amp; 2 C 2 8 3 (t »J = 4 2 8 2 (t» J — 4 2 7 0 — 2 6 0 (m 2 4 5 —— 2 3 0 C m 5. 7 .7 Η z ) &amp; 7 Η ζ), a total of 6 (s), a total of 1 Η] 3 (m), a total of 1 Η] 1 Η ζ) &amp; Η ζ)., a total of 1 Η]; 1 Η); 1 Η). Example 4 3 Diol 162: Let epoxide 161 (437mg, 1.23mm〇i) in THF (20mL) / H20 (10mL), which contains 5 drops of 70% HC504, gently back order For this paper, the Chinese national standard (CNS> Λ4 specification (2 丨 〇 × 297 mm) A7 B7 426663, V. Description of the invention (349) flow for 1 hour "was added to the paper, concentrated in vacuum. The residue was concentrated in vacuo. The material was dissolved in E t OA c, washed with brine, and dried. The crude diol 1 62 was concentrated in vacuo to give a light oil (full yield). It was used directly in the next reaction without purification. 眚 Example 4 4 Aldehyde 1 6 3: Oxidation of diol 16 2 according to the procedure described by Vo-Quang and colleagues, 68 (1988). Na I 0 4 (4.4 mL, 0.6 5 M aqueous solution) was added to the silicone (4,3g) in a slurry of dichloromethane (30mL). A solution of crude diol 162 (520ffig) in EtOAc (5mL) / CH2CJ? 2 (15mL) was added. After 1 hour, the solid was filtered off, and 20 % Hexane / E tOAc. Concentrated to give an oily residue, which was dissolved in E tOA c, dried over Mg S 04 ”and concentrated in vacuo to give a light oily aldehyde 1 63, which was used directly in the next reaction. 1 H NMR (CDC13, 300MΗζ): δ 9. 69 (s, lH); 6. 9 8 (m &gt; 1 Η); Printed by the Consumers ’Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs 4. 72 (dd, lH, J = 3. 7, 9. 1 Hz ); 4. 53 (d, lH, J = 18. 3 H z); 4. 45 (d, lH, J = 18. 3 H z); 4. 3. 1 (m &gt; 1 H); 4. 2 6-4. 1 8 (m * 1 H); 3. 7 9 C s · 3 H); 3. 1 9 (s »3 H); 3. 05 (dd, lH, J = 5. 7 * 18. 6Hz) The size of this paper is applicable to Chinese National Standard (CNS) Λ4 specification UlOXW ·? Mm) 352 4 2 6 6 6 3 Λ α7 __Β7 V. Description of the invention (35〇); 2. 2 0-2. 4 5 (m &gt; 1 Η). Example 4 5 Alcohol 164: Crude aldehyde 16 3 According to the procedure described by Bor ch and colleagues, M. Amer. Chem. Soc, 93: 289 7 (1 97 1), treated with Na CNB H3, flash chromatography (4 0% hexane / EtOAc) yielded 269 mg (65%) of alcohol 164: 1 H NMR (CDC13, 300 MHz): &lt; 5 6. 9 1 (m, 1 Η); 4. 75 (dd, 1H, J = 3. 9, 8 · 7 Η z); 4. 3 4 (brt, lH, J = 4.1Hz); 4.25-4. 15 (m, lH); 3. 8 5-3. 7 0 (m-4 H); 3.77 (s, 3H): 3. 16 (s, 3H); 2. 95 (dd, lH, J = 5. 7, 18. 6 H z) r 2. 37 (dd-lH &gt; J = 7.1 * 18. 6 H z) Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs 2. 26 (brs, lH). Example 4 6 Aziridine 165: Acetylation of alcohol 164 (208mg, 0, 62mmojZ) by conventional method (AcCi ?, pyridine * dichloromethane, DMAP catalyst), to obtain acetate (241mg, applicable to paper size China National Standard (CNS 丨 A4 Specification (ϋχ297mm) &quot;: -353-4 266 6 3 A7 B7 Pentaester Mixture M Invention Description (351) 0%]. Order in THF (12mL) at room temperature Crude acetic acid (202 mg 1 0. 54mmoJZ) was treated with Ph3P (55mg) for 2 hours. Then ΛΗ20 (1.1 ml and triethylamine (224 # L) was added and the solution was stirred overnight. The reaction mixture was concentrated, The residue was distributed between ethyl acetate and saturated bicarbonate / brine. The organic layer was dried, concentrated in vacuo, and purified by flash chromatography (10% _eOH / EtOAc) to give aziridine 16 as a white solid. 5 (25mg, 90%). H NMR (CDC13 · 300MHz): δ 6. 80 (m &gt; lH) \ A. 44 (br s, lH) 4. 23 (t * 2H * J = 4.8 Hz) ; 3. 82-3.65 Cm, 2H); 3. 2. 2. 2. 7 4 (s, 3 H); 8 5 (brd, 16 5-2. 4 0 (m

H H) Please listen to the notes on the back first

Page order

2 H 0 9 (s, 3 H); 2 5 (b r s, 1 H) Printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs

Example 4 7 N-Boc aziridine 166: Boc anhydride (1 13 mg · 0.52 mmo 芡) was added to aziridine 165 1 2 5 mg &gt; 0.4 9 mmo 9.), triethylamine (70烊 'DMAP (catalytic amount) was concentrated in a solution of dichloromethane (7mL) for 1 hour, and the residue was subjected to flash chromatography (40% E t 〇 A

L This paper size applies Chinese National Standard (CNS) Λ4 specification (210X297 mm) -354 426663 A7 B7 Consumption cooperation between employees of the Central Standards Bureau of the Ministry of Economic Affairs Du Yinhang V. Description of the invention (352) Owned house) Purified 1 5 4 m 8 (8 8%) light oily N-Bo C nitrogen η steep 0 1 Η N MR (c DC 1 3, 3 0 0 Μ Η z); δ 6 8 2 (m ♦ 1 Η) f 4 4 7 (brm 9 1 Η) »4 2 3 C t 9 2 Η * J = 4 · 7 Η Z); 3-8 1 (t * 2 Η 9 J 4. 7 Η Z); 3 7 5 (st 3)) »3 0 0 (brdf 1 Η J = 1 8 0 Η Z) 2-9 0 — 2 of which 8 5 (m 2 Η) 9 2-6 5 — 2 5 5 (in 1 Η)» 2- 1 0 (s 3 Η) 1.4. 4 4 (S, 9 Η) Example 4 8 Azide 1 6 7 Let aziridine 16 6 (1 5 4 m S 0.4 4 mm 0) &gt; Azide Sodium chloride (2 1 6 mg) eta β = ^ and gasification male (2 2 3 mg) were heated in D MF (5 m L) to 100 ° C for 18 hours 0 The reaction mixture was cold After, distributed in m my diethyl ether and the ether layer was washed with water after the wash water and brine and dried (Μ g S 0 4). Concentrated to give a crude residue y at room temperature. I C I 2c SI 2 was treated at 40% ΤFA. Concentrated in vacuo after 2 hours to obtain a light-colored oil * Pass it through a short silica gel column (stripped with E t 0 A c) 0 In the conventional manner (A c C Si Pyridine 1 Dichloromethane 9 D Μ AP catalyst ) Tritiated, flash chromatography (5% Me 0 Η / chloroform) yields vinegar 16 7 »It is a light yellow oil. The paper size applies the Chinese National Standard (CNS) Λ4 specification (210 · &gt; 297 mm). -355-Printed by the Shellfish Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs 4266 6 3 Λ Α7 __Β7_ V. Description of the invention (35 to 16mg (three steps total 11%). 1 H NMR (CDCla * 300MHz): δ 6.8 5 (m, 1 Η); 5. 80 (brd, lH'J = 7. 8 Η ζ); 4. 5 5 (m &gt; 1 Η); 4. 25-4. 10 (m * 3 Η) ; 3. 9 0-3. 8 5 (m * 2 Η); 3. 7 8 (s-3 Η); 3. 5 5 (m * 1 Η); 2. 90 (dd, lH, J = 5 4 * 17. 0 Η ζ); 2. 4 5-2. 2 5 (m * 1 Η); 2. 10 (s, 3H); 2. 05 (s, 3H). Example 4 9 Amine Acid 168: Aqueous KOH (208 / zL, 0.476M) was added to a solution of ester 167 (16 mg, 0-047 mm) in THF (1 mL) at 0 ° C. The reaction was then allowed to react Warm to room temperature and stir for 2 hours, then acidify with Amber lite IR-120 (plus) acidic resin to pH = 4.0. Filter out the resin, wash with ethanol and 112◦ * concentrate in vacuo to give 14mg (100%) white The solid azidocarboxylic acid was dissolved in ethanol (2 mL), and the procedure was described in Corey and colleagues, 'Synthesis &quot;, 5 9 0 (1 975) in a LindUr catalyst (15' mg) with hydrogen (1 atm ) Treatment for 16 hours. The reaction mixture was filtered through a pad of diatomaceous earth, washed with hot ethanol and water. ”A light orange solid was obtained after vacuum concentration. • C18 column chromatography (Chinese standard (CNS) A4 for the scales) Grid (ΐΓ〇 × 297mm) * ^ Binding m _ Therefore \ ly 『-. (Please read the precautions on the reverse side before going to this page) -356-426663 A7 B7 V. Description of invention (office) h2o 8) 白粉 168。 Purification, the fractions containing the product were combined and freeze-dried to give 9.8 mg of white powder 168. 1 H NMR (D2 · 500MHz): 6 6. 5 3 (brs, lH); 4. 2 8 (brm, lH): 4. 08 (dd, lH, J = ll · 0, 11 · 〇H z) ; 3. 80-3. 65 (complex m, 4H); 3. 4 4 (m, 1 H): 2.84 (seems to be (1 (1, 111); 2.46-2. 39 (complex m, lH); 2.08 (s, 3H).

Cautious example 5 D cyclic amino acid MOM ether 19 (PG = methoxymethyl): According to Mordini and colleagues, ^ J. 0 r g. C hem 〃, 5 9: 4 7 8 4 (1 9 9 4) The procedure described was prepared from epoxy alcohol 1 (74%). Η 1 2 ΗΜ ο ο 3 3 IX CDC / IV RM Ν δ Printed sheet of paper by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs Η Η ο Η = Η 1 1 3 4 3 J 1 mt S 3 s dm / V ( / V j / V / iv c 3 9 6 0 8 0 5 7 5 7 5 4 1 4 6 4 3 3 3 3 2 4

J 3 m s ζ m (Η (; 7 4 7) 8 5 Η • 2 1 ζ Η 5 9 β

Ns c-(I rate-standard I

4 AI centimeters 7 -9 2 X ο 35 4266 6 3 4 A7 B7 V. Description of the invention (355) Window example 5 1 Aziridine 1 7 0 According to the general steps described in Examples 3 and 4, the cyclic compound 19 (PG = Methoxymethyl) (total yield 77%). 1 Η NM MR (CDC 1 3 1 3 0 C 1 MU Η 2) δ 6. 8 5 (m 1 Η) 4. 7 8 (s, 2 Η); 4.5. 4 (m 1 Η) 3. 7 3 (S, 3 Η): 3.4. 1 (s 3 Η) 2. 8 7 (d 1 Η J = 18 9 Η z) &gt; 2. 7 0-2 4 5 (m * 3 Η) ο Please refer to page I h on page 5 Example 5 2 Azide 22 (PG = methoxymethyl): let aziridine 170 (3 2 9 mg * 1.5. 4 4 mm ο ^) &gt; N a N 3 (446mg ) And NH4Ci (151 mg) in DMF (20 mL) and heated at 65 ° C for 18 hours. After the reaction mixture was cooled, it was distributed between ether and brine. The ether layer was washed with water, brine and dried (MgSO4). Concentration in vacuo gave the crude azide.amine as a light oil, which was eluted with CH2Ce2 (15 mL) and treated with pyridine (4 mL) and AcCj (150aL). Flash chromatography after isolation gave 350MG (76%) azide 22 (PG = methoxymethyl) as a light oil. 1 H NMR (CDC13, 300MΗζ): δ 6.7 8 (s, 1 Η); This paper size is applicable to China National Standard (CNS) Λ4 specification (210 × 29 · 7 mm) Staff of the Central Bureau of Standards, Ministry of Economic Affairs Printed by the Consumer Cooperative -358-A7 B7 4266 6 3 ^ V. Description of the Invention (356) 6. 3 9 (brd 1 H »J = 7.8 Hz); 4. 7 2 (d * 1 HJ = 6-9 Hz) T 4. 6 6 (d »1 H $ J = 6-9 Hz)» 4. 5 3 C brd »1 H &gt; J = 8.4 Hz); 4, 0 0 — 3 * 9 0 ( m 1 H) r 3. 8 0 — 3 * 6 5 (m 1 H) t 3. 7 5 (s »3 H) V 3 3 7 (sf 3 H); 2. 8 5 (dd ♦ 1 H» J = 5 • 4, 1 7. 7 H; 2. 3 5 — 2 2 0 (m »1 H), 2.0 4 (s-3 Η)-Window example 5 3 Amino acid 1 1 4: Corey and colleagues,% Synthesis (R), 590 (19 75), the azide 2 2 (PG = methoxymethyl) (3 9 mg * 0.131mm〇i2) with hydrogen (latm) and Lind lar catalyst (3 9 mg) was processed in ethanol for 2.5 hours and printed by the Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs. The reaction mixture was filtered through a celite pad and washed with hot ethanol and concentrated. A light-colored foamy crude amine was obtained, 33 mg (92%). The amine was treated with an aqueous KOH solution (380 kernels L '0.4 7 6 M) in THF (1 mL), and after 1 hour was treated with Amberlite IR-120 (plus) Acidic resin was acidified to PΡ = 4.0 &lt; * Then the resin was filtered, washed with water and concentrated to a light-colored solid, purified by C18 column chromatography (H20 stripping), and the fractions containing the product were collected , Freeze-dried to obtain 20m g of white powder, 1 1 4. __ This paper size applies to Chinese national standards (CNS} A4 specifications (210X297 male thin) -359-4 2 66 63 ^ A7 B7 V. Description of the invention (357 ) 1 H NMR (D2O0, 300MHz): &lt; 5 6. 6 5 (s, 1 Η); 4. 87 (d, lH, J = 7.5 5 Η ζ); 4. 76 (d, lH, J = 7 · 5 Η ζ); 4. 4 7 (brd, lH, J = 8.7Hz); 4. 16 (dd, lH, J = ll. 4, 11. 11. 4 Η ζ); 3. 70-3. 55 (m-lH); 3. 4 3 (s, 3 Η); 2. 95 (dd, lH, J = 5. 7, 17. 4 Η ζ); 2. 6 0-2. 4 5 (m · 1 Η): 2. 1 1 (s, 3 Η). Example 5 4 Amino acid 171: 40% TFA / CH2C ^ 2 (1 mL, cooled to 0 ° C before addition) was added to a solid amino acid 1 1 4 (4 mg, 0.0 1 5 mm) . The reaction mixture was allowed to stir at room temperature for 1.5 hours. After concentration, a white foam was obtained. Co-steamed with H20, printed several times by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs, freeze-dried to obtain 5.5 mg of a white solid, which is a THF salt. 0 H NMR (D2O * 300MHz) δ 6.85 (m, lH); 4.45 m, lH): 4.05 (dd, lH, J = ll. 4, 11.4 Η z); 3. 6 5-3. 5 5 Cm- 1 H); 3. 0 0-2. 9 0 (m-1 H); This paper size applies the Chinese National Standard (CMS) A4 specification (2 丨 Ox 297 mm) -360-4 266 6 3, a? B7 V. Description of the invention (358). 2. 60 — 2. 45 (m, lH); 2.09 (s, 3 Η). Example 5 5 Acetone 180: p-toluenesulfonic acid (274mg, 1.44mmoJ ?, lm05%) was added to a suspension of shikimic acid (25g, 144mm JZ * Aldrich) in methanol (30 OmL), This mixture was heated at reflux for 2 hours. More p-toluenesulfonic acid (1 m 5%) was added and refluxed for 26 hours and evaporated to dryness. The crude methyl ester (

28.17 g) was suspended in acetone, treated with dimethoxypropane (35 mL, 288 mm), stirred at room temperature for 6 hours, and then evaporated to dryness. This crude product was dissolved in ethyl acetate (400 mL), and washed with saturated NaHC03 (3 x 125 m.L) and saturated NaCJ®. After the organic layer was dried (Mg S 04) and filtered, it was evaporated to dryness to obtain crude acetone 180 (~ 29.4g), which can be used directly: 1 H NMR (CDC 13) δ 6. 91 (t, lH, J = 1.1. ), 4.74 (t * lH.J = 4.8), 4. ll (t, lH, J = 6-9)-3. 9.9 (m, 1 Η), 2. 79 (dd, lH , J = 4.5, 17.4), 2. 2 5 (m * 2 H), 1. 44 (s, 3H), 1.40 (s, 3H). This paper is the standard of China National Standards (CNS) M specifications (21 × 297 after the male) -361-A7 B7 4266 6 3 ^ — ~ _ V. Description of the invention (3 trainings)

Mjm 5 b mesylate 130: add triethylamine (29.5 m L &gt; (please read the meaning on the back before filling in the textbook) 2l2mmoJ2) to acetone 18 ° C (29 ° C) 4 S'141mmo.) Solution of CH2Ci2 (250mL) g, 91%), which is viscous, followed by the addition of methanesulfonyl chloride (13. 6mL, l76mmoj2) during 10 minutes. The reaction was allowed to stir at 0 ° C for 1 hour. Ice water (250 ml) was added to the separatory funnel. The organic layer was washed with water, 5% citric acid (30mL), saturated NaHCO3 (300mL), and dried ( Mg S04), filtered and evaporated to dryness. The crude product was filtered through a sintered glass funnel (filled with a small piece of silicone) (stripped with ethyl acetate). The filtrate was evaporated to dryness to give mesylate 130 (39. Sugar oil 'and used directly in the next step: 1 Η NMR (CDC 1 3) 6 6-9 6 (m &gt; 1 H). 4 4. 28 ( dd * lH * j = 3. 7 9 (s · 3 H), 3. 3. 01 (dd, lH, J = printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs 8 0 (m, 2 H) 6. 6 &gt; 7. 5) 1 2 (s, 3 H) 5,. 1 7 · 7), H). 2. 56 — 2 · 4 6 Cm »Example 5 7 g of diol 131: p-toluenesulfonic acid (1.15 · 85mm〇j, 5mJ2%) was added to mesylate 130 (35 · 85g , 117mmoJ?) In methanol (500mL) solution 'The solution was refluxed for 1.5 hours after evaporation. The residue was re-dissolved in A. The paper size is in accordance with Chinese National Standard (CNS) 8 and 4 (210X 297 mm) -362-4266 6

A A7 B7 V. Description of the invention (360) After alcohol (500 mL), reflux for 4 hours. The solvent was evaporated, and the crude oil was rolled with diethyl ether (2 5 OmL). After crystallizing overnight at 0 ° C, the solid was filtered off * washed with cold ether and dried to give diol 131 (24.76 g) as a white solid. After the filtrate was distilled off, the residue was crystallized from methanol / ether to obtain 1.55 g. A total of 26.3 g (85%) of diol 13 1: 1 H NMR (CD3〇D) δ 6. 8 3 (m · 1 Η) &gt; 4. 8 6 (m &gt; 1 Η), 4. 37 (t, 1H, J = 4.2), 3. 87 (dd, 1H, J = 4.2, 8. 4), Please read the note of dt first and then fill in the pages 7 s, 3 H), 3. 13 (3 H) 2. 9 8-2. 9 0 (m &gt; 1 H) 2. 5 3-2. 43 ( m, lH) Example 5 8 Epoxy alcohol 1: In OeC, a suspension of tetrahydrofuran (400 mL) of diol 131 (20. 78 g 78 mm 05) with 1 8-diazabicyclo [5. 4 · 0 ] Undecyl-7-ene (11.7 mL, 78 mmz printed by Shelley Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs) was treated and stirred at room temperature for 9 hours to complete the reaction. After evaporation to dryness, the crude residue was dissolved in CH 2 C 2 (200 mL) and washed with saturated NaC 5 (300 niL). The aqueous layer was extracted with CH 2 C) 2 (2 × 200 mL). The organic extracts were combined, dried (Mg S04), filtered and evaporated to dryness. The crude product was purified by silica gel (ethyl acetate) to obtain epoxy solid alcohol 1 (12g, 90%) as a white solid. The 1H NMR spectrum was consistent with the report in the literature: The standard of this paper applies the Chinese National Standard (CNS) A4 specification (210X297) (%) 426663 4 A7 _______B7____ V. Description of the Invention (361)

McGowan, D.A .; Berchtold, G.A., 'J. Org. Chera., 46: 2381 (1981). Example 5 9

Methoxymethyl ether 22 (PG = methoxymethyl): N, N &gt;-diisopropylethylamine (12.3mL, 70.5mm〇i) was added to the epoxy alcohol 1 (4g, 23.5mmoj ?) In CH2CJ? 2 (100 mL) solution, followed by the addition of chloromethyl methyl ether (3.6 ml, 47 mm ?, obtained from industrial-grade distillation). After the solution was refluxed for 3.5 hours, the solvent was distilled off, and the residue was distributed in ethyl acetate (200 mL) and water (20 mL). The aqueous layer was extracted with ethyl acetate (100 mL), and the organic extracts were combined, washed with saturated NaCj? (100 mL), dried (MgS04), and evaporated to dryness to obtain 4.9 g of a solid residue, which is suitable for direct use. In the next step. Mp62-65 ° (crude): mp64-66 ° C (acetic acid / hexane); 1 H NMR (CDC13) 5 Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs)) Η Η Η Η Η mil τ * ΙΑ IX,,,, '' stacked cr mmE weight dd / V XIV / fv / IV VC / c \ 3 9 7 8 7 7 7 5 5 4 0 4 6 4 3 3 3 2 3 3 2 3 tfss / V (7 5 8 7 4 3 H 4 s

J J 2 2 7

IX 8 Standard bidder I Country ί I Middle 9

X | centimeter 4266 6 3 ^ Α7 Printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs _ B7 V. Description of the Invention (362) Ethyl Congeners of Compound 2 2: Diisopropylethylamine (34.0 mL, 〇 13mm) CH2CJ? 2 (277mL) solution of the corresponding ethyl ester (12.0 g-0.065m2) of compound 1 added to room temperature, followed by the addition of chloromethyl methyl ether (10.0mL, . 19 m 〇 ^). The reaction mixture was gently refluxed for 2 hours, cooled and concentrated in vacuo, and then redistributed in Et OA c and water. The organic layer was separated, washed sequentially with dilute HCi2, saturated bicarbonate, brine, and dried over MgS04 and concentrated in vacuo. Flash chromatography (silica gel, 50% hexane / EtOAc) was then performed to obtain 13.3 g (90%) of the corresponding ethyl ester of compound 22 as a colorless liquid. 1 H NMR (300MHz &gt; CDC13) δ 6. 7 3-6. 71 Cm · 1 Η): 4.87 (s-2H); 4. 6 1-4. 57 (m · 1 Η); 4. 21 ( q * 2H * J = 7. 2 Η ζ); 3. 6 0-3. 5 5 (m · 1 Η); 3. 5 0-3. 45 (m * 1 Η);

3. 4 8 (S, 3 Η); 3. 1 2 — 3 .0 5 (m, 1 H): 2. 5 2 — 2 .4 2 (m 1 1 H): 1. 2 9 (t, 3 Η ， J = 7 2 H Example 6 0 This paper size is applicable to Chinese National Standard (CNS) Μ specifications (210X297 mm) il Please read the precautions on the back before binding glands-365-A7 B7 426663 ^ 5. Invention Explanation (363) Alcohol 181: Sodium azide (7.44 g '. 114. 5 mmoJ2) and chlorinated chloride (2.69 g * 50. 4 mm〇5) were added to methoxymethyl ether 22 (PG = Methoxymethyl) (4.9g, 22.9mmoj?) In 8 / 1__Me0H // H20 (1.75mL, v / v) solution 'Allow the mixture to reflux for 15 hours. Dilute with water (75mL) to dissolve The precipitated salt was concentrated to remove the methanol. The resulting aqueous layer containing the precipitated oily residue was diluted with water to 200 mL and extracted with ethyl acetate (3 x 100 mL). The organic extracts were combined and washed with saturated NaCi® (100 mL). , Dried (Mg S04), filtered, and concentrated. The crude product was purified with silica gel (1/1 —hexane / ethyl acetate) to give alcohol 181 (5.09 g -8 6%) as a pale yellow oil. Alcohol 1 8 1 can be used directly in the next step without further purification. Preparation. Please read the notes on the back before binding

Nl / 3 Printed by the Ministry of Economic Affairs Bureau of Shellfish Consumer Cooperatives 1 3 xly J, 1), Η, Η CHt53Hlo D IX, IX, 00 C, Γ s »d (m b- 3 (dd 2 R ((1 3 ((I M6104271 N 8 3 9 9 8 2, 3 .., H 6 4 3, 2 2 2 1

Xu) s Η, 2) m ， 2 has s. # C 4 weight 9 = (. 7— J τ &gt; 7 4 H. Η 5 marry lx 6 cases m 6 8 IX) 4 〇CO \ 1 / 5 Η 6 II 1 II J 丨 L m 4 4 c- Aminoethylene triacetate will follow the order of 4 8 1- Sulfomethyl ester This paper is in accordance with Chinese national standards (CNS &gt; Λ4 size (2! 0X 297g t) A7 B7 Printed by the Consumer Cooperatives of the Central Bureau of Standards of the Ministry of Economic Affairs 426663 V. Description of the Invention (364) 31.5mmoj?) And Methanesulfonyl Chloride (2.14 m L-27. 7mmo) Alcohol 181 added to 0 ° C (6.47 g, 25.2 mmo;?) In a solution of CH2Ci? 2 (100 mL). The reaction was allowed to stir at 0 ° C for 4 5 minutes, then warmed to room temperature and stirred for 15 minutes. After evaporation to dryness, the residue was distributed between ethyl acetate (200 mL) and water (100 mL), and the organic layer was washed with water (100 mL), saturated NaHC03 (100 mL), and saturated NaCj® (100 mL). The water washing solution was extracted with ethyl acetate and washed with NaHC03 / Na CJ? Solution. Combine organic extracts and dry (

Mg S 04) After filtration, it was evaporated to dryness. The purity of the crude product is suitable for use directly in the next step: work! !! NMR (CDC 13) δ 6.85 (m, lH), 4-82 (d, lH, J = 6.9), 4 4 4 3 3 2 2

H 2 ο * 9 2 Niy 9 4 9. II 3 J 6 ||, II JHJ 1 1, H, Hit,, drddbcc 3 7 3 7 6 5) H uo ^^ 3 3, 丨, dssd c. C- -c 8 5 8 T -— * 9 NH 3 s 4 3

Nuy · 6 8 1 o 6 c HD 1 6 c, 9 / tv mt, R (6 7 m N 3 9 ΝΪΧ 3 6 9 6 5, 6 4 1 5 8 7 4 3 3 2 5 7 5 5 8 5 5 6 9 2 2 8 3 This paper size applies Chinese National Standard (CNS) specifications (210X297 mm) 367 Β7 Printed by the Central Standard of the Ministry of Economic Affairs 扃 Shellfish Consumer Cooperatives V. Description of the invention (365) 1! Example e 2 1 1 Nitrogen Propidium 17 0; add Ph 3 P (8.2 t II 3 1 mm 0) to the formic acid ester 1 8 4 (8. 5 6 g »1 1 2 5 mm 0) at 0 ° c Τ Η F (150 m L) solution t and it is cold, please read 1 1 before adding 1/3 of the amount 9 Remove the ice bath and read the back 1 1 1 in 5 minutes Add P h 3 Ρ. Stir at room temperature for 3 hours after the addition is complete. Note that a white precipitate will form during this time. Ο In this suspension, add triethylamine. 1 I (5.2 m L 3 7 5 mm 0 9.) and water (10 m L), pi Let this mixture be stirred at room temperature for 12 hours. Concentrated to remove T Η F * residue 1 1 The material was distributed in C Η 2 C j? 2 (200 m L) and saturated Na C J2 (1 12 0 m L). The aqueous layer was extracted several times with C Η 2 C 芡 2 &gt; combined organic 1 1 The extract was dried (Mg S 0 4), filtered, and evaporated to give the crude product. * I was purified by gelatin (10% Μ e 0 Η / E t 0 A c) to obtain an oily 1 1 1 of Aziridine 17 0 (4 • 1 8 g 7 8%)-which-generally contains traces of 11 triphenylphosphine oxide impurities i 1 1 Η N MR (CDC 1 3) δ line 16. 8 1 (m 1 1 Η) 4 * 7 8 (S, 2 Η) 9 j 1 4. 5 4 (mt 1 Η) &gt; 3 7 3 (S, 3 Η) 9 1 I 3. 4 1 (s &gt; 3 Η) t 1 1 Ι 2. 8 7 (seems to be dd 9 1 Η) »1 1 ι 2. 6 4 (b Γ st 1 Η) 1 1 2. 5 6 1 2-4 7 (m» 2 )) 1 1 Ν Η The signal is not obvious: 1 1 1 3 Η NM MR (C DC 3) δ 1 6 6 .9 1 3 2. 5 I 1 This paper's standard is applicable to Chinese National Standard (CNS) Λ4 210X297 mm) -368-42666 3 Λ V. Description of the invention (3 66) &gt; 12 8. Ο, 9 5 5 1. 6-31. 1 Α7 Β7 9, 6 9. 5, 5 5. 2 2 7. 7-2 4.1. Printed by the Central Standards Bureau of the Ministry of Economic Affairs, Shellfish Consumer Cooperative, Example 3 Amine 1 8 1 5 mm 〇 (4 0 ° C) with sodium azide 1.6 g, 7 〇 ΐ calendar 2 ～ 1 〇 〇 m ether (1 Ο The organic layer was then treated with (M g SO 'Ibid. 5% Me (2.95 Impurities: 1 H NM 6.82 4.81 4 · 7 7 2: aziridine 170 (3.2 g &gt; text) The DMF (30raL) solution was degassed by applying a vacuum to the concentrator for several minutes. Then (4.9 £, 75111111〇 芡) and ammonium chloride (30 mm 0J2) were added, and the mixture was heated. To 65-1 hour. After cooling to room temperature, diluting with ethyl acetate (L) and filtering. Evaporate the filtrate to dry out the residue in OmL) and saturated NaCJ? (100mL). Saturated NaCJ? (100mL) Wash once, dry 4), filter and evaporate to dryness. The water washing solution is extracted with ethyl acetate, and the crude product can be obtained after treatment. The crude product is purified by silica gel (0H / CH2Ci22) to obtain an oily amine 1 8 2 g ), Which causes a small amount of triphenylphosphine oxide R (CDC (t, 1 Η (d, 1 Η (d, 1 Η δ 27 6 3 2 4, 0 9-4. 0 4 (m Η 3 7 6 (3 Η) Table paper size suitable for China national standard Standard (CNS) Α4 size (210 × 29 ·? Mm) 369-42666 3 4 A7 B7 Printed by the Consumers' Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs

V. Description of the invention (367) 3-4 7 and 3 4 4 (S »4 with m superimposed) 9 2-9 4-2 8 6 (1X1» 2 Η) 2 3 6 — 2 2 4 (m &gt; 1 Η) &gt; 1 3 Η NMR (CD 1 3) &lt; 5 1 6 5 • 9 9 1 3 7. 3 »1 2 8 2 1 9 6 • 5 * 7 9-9 6 1 * 5 * 5 5 * 7 y 5 5 • 6 »5 1 * 9 y 2 9 * 5 Example 6 4 Ν—Trimethoprim 1 8 3: Amine 1 8 2 (2 5 9 S 1 0 2 m τη 0 ) Dissolved in 5%% C / Μ e 0 Η (30 m L), and the solution was stirred at room temperature for 3 hours. Then add 5% Η C / Μ e 0 Η (10 m L) and stirred 1 hour »2 5 2 g Η C salt obtained after evaporation of the solvent under high vacuum» This is a color-grasping solid 0 here C Η iZ salt C Η 2 C i? 2 (5 0 τη L) suspension * 0 eC added at Ethylamine (3.55 m L »2 5 • 5 mm 0 9.) Then-once add solid tribenzyl-ΙΑ 醯 chloro (5-5 5 S 9 1 2 * 8 mm 0 9.) 〇 order This mixture is Stir at 0 ° C for 1 hour and then warm to room temperature for 2 hours and then cool to 0 ° C. 9 Add rr ethylamine (3 • 6 m L 9 2 5 5 mm 0 9.) Add methanesulfonium gas (0 9 7 m L y 1 2 5 m ΤΠ 0 H) 9 The resulting mixture was stirred at 0 ° c for 1 hour &gt; and then stirred at room temperature for 2 2 hours. 0 After evaporation, the residue was distributed in ether (2 0 0 m L) and water (200 m L) with 0 awning layer. Wash with water (200 m L) &gt; Combine the water layer »Extract with ether (200 m L). Combine the organic extracts to Water c 1 0 0 0 m L Please read first -¾ Back © Note The page size applies the Chinese National Standard (CNS) A4 specification (2 〖0X297mm） -370-f more, txia back to Coonmi (CTI ^ S &gt; Miscellaneous 210 × 297Ό #

丨 3T1 I &lt; σ 卬 Q times) J, o on H-0 i μ. W ^ su / ra (2mL) ugly) s-iA ^ ld MVI — ♦ The invitation window is odd and the N photo is Nstos ^-δ . za Ci2i is thin. Guluzo c I I δ- i (1 \ 1 IQ —

4 ^ ^ 卬 ^ φ · ί looms: Ξ ϊΛσ 碧 I w Ύ 3 3 2sμ ϋ 05 — ^. Stimulus II hangs on St i M 1 卬 m m 〇> 0 w 1 3 SJ / I $ 1 broadcast, w nt. ^ sp 2 pso OMS ^ SU S: S o ") Bacteria Record Wei Wei. N * i ^ N-sv μ 9 0-φ 2 —Chuanshu Meow | Nuo 3 Pan X S3 (, ο, 33mmo &gt; 2) Ride (2mL) NI λ ^^^ νμι ^ o, 3 卬 330 ^ 2): ^ — A ΛΛ +

CD kernel——S 3 Sο e (m C d f + μϊ), μϊ sec μκ) Η X,

J 3 ο), β μ I Η V ΗΜ) &lt; s 3-3 ϊ) -Ύ, 1) ies) &gt; (3es) I s su zanw ^ (200mL) ifii iVts: 3 o ") ® 翁 杂1 s. Xue I i OKOKMOioM] l · Wan He3 (3-i MI JSTlVirt Ando HQV ^ &gt; rj 426663 B7 Printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs 5. Description of the invention (369) 1 0 7 ° C ( Ethyl acetate / hexane) 1 Η N MR (c DC 1 3) δ 6 7 8 (m 1 Η) 6 1 1 C dt 1 Η J = 7 * 4) 4 6 1 (τη 9 1 Η) 1 4-3 2-4 2 3 (m »1 Η)» 3 7 6 (s * 3 Η) 3 4 4-3 2 8 (m &gt; 2 Η) 2 8 5 (dd »1 Η, j = 5 7 »1 7 .6) 2 2 8 — 2 1 7 (m» 1 Η) 2 0 4 (s 3 Η) i 1-8 8 — 1-1 9 (m »1 0 Η) ο Example ρ 6 Compound 1 9 1 Add triphenylphosphine (5 7 m S 0 * 2 2 ΠΊ m 0 9.) and water (2 7 0 β L) to THF of compound 1 0 (4 9 mg 0 * 15 mm 0) The solution was then heated at 50 ° C for 10 hours. After evaporation to dryness, the residue was dissolved in ethyl acetate, dried (M ss 0 4), filtered and evaporated to dryness. The crude product was placed on a silica gel (1/1-M e 0 Η / Ε to A c) Purified to give a light yellow solid IUZ. Amines (46 mg) a a 1.03 9 NK 0 Η solution c 2 1 7 UL) and water (2 0 0 β L) At this point, the THF (15 m L) solution of amine was stirred at room temperature for 1 hour and then cooled to 0 ° c. 9 Acidified with IR 1 2 0 ion exchange resin to form PΗ 6 6 .5 This paper is scaled to China. Standard (CNS) A4 specification (21 OX2 mm) -372-4266 6 3 Λ Α7 ^ A 7 ___ Β7 V. Description of the invention (37〇) Printed resin by the Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs * Methanol: After cleaning »The filtrate was evaporated to dryness. The solid residue was dissolved in water and passed through a C — 1 8 reverse-phase silica gel column (4X1 cm« washed with water and later with 25% acetonitrile / water): the combined product part Τ Evaporate to dryness, dissolve the residue in water and freeze dry to give white Amino acid 1 9 1 (28 mg) 1 Η MR (D 2〇) 5 6. 4 7 (br S * 1 Η:) * 4. 8 0 (brd 1 Η:) * 4.0 0 (dd »1 Η, J = = 8.9, 1 1-6) &gt; 3. 5 9 — 3 hit 5 0 (m, 2 Η) · 2. 8 7 (dd» 1 Η, J = = 5 .5 * 1 7-2) »2. 0 6 (s» 3 Η) 9 1. 9 0 — 1-1 5 (series ofm-1 0 Η), C ι5Η 2 4 N 2 〇4 • Η 2 〇Theoretical value of elemental analysis: C, 5 7 3 1; H &gt;,8.34; N t 8 9 1 0 Found C t 5 7 3 8; H ', 8.09; N 9 8-7 7 0 Careful example 6 7 2—B 0 c guanidyl ester 2 0 1: According to the steps of K im and Q i an, * Tetrahed r ο Lett tf &gt; 34:76 77 (1 993)-H g C ίί 2 1 (5 i 9 丨 3 mg 1 2. 1 8 1 mmo J2) —-Add 0 ° C amine 2 0 0 (5 2 9 mg '' 1 9 7m m 0 9. f Take the example 1 0 9 method) &gt; Twenty-one B 〇c thiourea (551 mg, (CNS) A4 (210X297 mm) (please read the back first Notes on this page)-Installation _ Staple 4266 6 3 ^ A7 B7 V. Description of the invention (371) 2. 0 2 mm 0) Cfef and E t 3N (c) 3 0 Ren L) anhydrous DMF (50 m L) solution. The heterogeneous reaction mixture was stirred at 0 ° C for 4 5 minutes * and then stirred at room temperature for 15 minutes, then diluted with E t 0 A c and filtered through a pad of celite. After concentration in vacuo, the residue was subjected to flash column chromatography on silica gel (10% hexane / ethyl acetate) to give 904 mg (90%) of 2 0 1 0 1 NMR (c D c 1 3 * 3 0 C 丨 M Η ζ): 5 11 3 9 (s »1 Η); 8. 6 3 (d 1 H, J = 7.8 Η ζ); 6.8 9 ct» 1 H ， J = 2. 4 Η ζ); 6. 4 6 cd »1 H &gt; J = 8. 7 Η ζ); (Please read the notes on the back before ΐ / Qianjin page) Central Bureau of Standards, Ministry of Economic Affairs Printed by Employee Consumer Cooperatives 4. 4 3-4. 3 2 (m * 1 Η); 4. 2 7-4. 1 7 (m * 1 Η); 4. 13-4. Ο 6 (m * 1 Η ); 3. 7 7 (s * 3 Η); 3. 6 7-3. 5 9 (m * 1 Η); 2. 83 (dd, lH, J = 5.1, 17. 8 Η ζ); 2. 4 5-2. 3 3 Cm- 1 Η); 1. 9 5 (s &gt; 3 Η); 1. 65-1. 50 (m &gt;2H); 1. 4 5 (s * 1 8 Η); 0. 90 (t, 3H, J = 7. 5 Η ζ). Example 6 8 scales apply Chinese National Standard (CNS) Λ4 specification (210 X 2 mm) '-374-A7 B7 426663 ^ V. Description of the invention (372) Carboxylic acid 202: KOH aqueous solution (3.4. 5 m L * 1. 039 N) was added to a solution of methyl ester 201 (904 mg, 1. 77 mmo 芡) in THF (10 mL). The reaction mixture was allowed to stir at room temperature for 17 hours, cooled to 0 ° C, and acidified with Amberlite IR-120 (H +) acid resin to pH 4.0. The resin was filtered off, washed with water and methanol, and concentrated in vacuo to give a light foamy free acid, which was used directly in the next reaction without purification. Example 6 9 Guanidinecarboxylic acid 203: Pure trifluoroacetic acid (25 mL) was added to 0 ° C bis-B guanidine carboxylic acid 2 0 2 (crude obtained from the previous reaction) CH2C $ 2 ( 4 mL) solution, the reaction mixture was stirred at 0 ° C for 1 hour, and then stirred at room temperature for 2 hours. Concentrated in vacuo to give a light orange solid, which was purified by C18 reverse phase chromatography (extracted with water). The fractions containing the expected product were collected and freeze-dried to give 49 5mg (68%, 2 steps) of guanidinecarboxylic acid 203 trifluoroacetate β 2 D / IV RΜ Ν Η ζ ΗΜ ο ο employees of the Central Standards Bureau of the Ministry of Economic Affairs Consumer cooperative printing 6 9 6 2 1 ο 4

) Η Η Η 1 1 1-- *, * ddsbd (rv / IN ζ Η Ν Η 8 6 7 7 XJ- Η 1m / ι \ Η 1 fm ο 6) H 1 fm Χί ο 5 Η 1 × 1 1-) -z Η 4 quasi-standard home country No.1 high school uses a suitable ruler i sheet of paper 1 centimeter-public 4266 6 3 A7 B7 printed by the staff consumer cooperative of the Central Standards Bureau of the Ministry of Economic Affairs 5. Description of invention (373) t 2 4 7 — 2 3 6 (m 1 Η) »2 0 6 C s 9 3 Η) &gt; 1 6 5 — 1 • 5 0 (m &gt; 2 Η) 0 9 0 (t» 3 Η 9 j = 7.2 Η Z) 〇C 1 5 Η 2 Ξ 〇βΝ 4 F 3 theoretical value of elemental analysis C 9 4 3 * 6 9 * Η 1 5. 6 2: N 1 1 3 * 5 9 O found * C t 4 3 * 2 9 * Η t 5. 9 0; N 9 1 3-7 8 o Example 7 〇 Formamide aminocarboxylic acid 2 0 4 Let amino acid 1 0 2 C 2 5 m S f 0 • 1 0 in m 0 il V (made from Example 1 10) in water (50 0 β L) solution at 0-5 ° C with 0-1 Ν N a 0 Η adjust P Η to 8 * 5 o ~~ Imine salt JOftL acid salt (4 5 mg 9 0 * 2 6 mm 0 9.) Add 1 to maintain the P Η of this anti-nrfef reaction mixture to 8 * 5 — 9 * 0 (with 1 • 0 NN a 0 Η). Stir at 0-5 ° c for 3 hours. Then concentrate in vacuum and purify by C 18 reverse phase chromatography (water extraction). 9 Collect fractions containing the expected compound. 1 Freeze-dried to give 40 mgc 1 3%) formamidine. Carboxylic acid 2 4 0 1 Η N MR (D 2 1 0 0 Η ζ) · δ 7 8 5 c S 1 Η), 6-5 3 (bd 1 Η 1 I 7.8 Η Z) 4 * 3 2 1 4 2 5 (bm 1 Η) f This paper size applies the Chinese National Standard (CNS) A4 specification (21 OX 297 mm) Please read the precautions at the back before t-376-4266 6 3 ^ V. Invention Instructions (374) Employees' Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs, A7 _____B7 4-1 0 to 3 • 9 7 (ΪΪ1 »1 Η) 3-7 6 to 3 • 6 7 (m« 2 Η) 3 5 7 1 3 4 9 (m »1 Η) 2 &gt; 8 6 — 2 8 1 (m 1 1 Η) 2 5 5 — 2 4 Q (m 1 Η) 2 • 0 4 (S 9 3 Η) * 1 6 5 — 1-5 0 (m 2 Η) * 0 * 9 0 (t 9 3 Η »j = 7.4 Η z) 0 Example 7 1 Amino acid 2 0 6 Aqueous K 0 H solution (4 8 1 β L »1 0 3 9 Ν) was added to the amino methyl ester 2 0 5 (8 4 mg, 0 3 3 1 mm 0 f Example 10 (prepared in Example 7) of TT F (1 * 0 m L) solution 0 The reaction mixture was stirred at room temperature for 2.5 hours &gt; acidified with Ambe r 1 te IR-120 (Η +) acidic resin To ρ Η 6-5 The filtered resin was washed with water and methanol> concentrated in vacuo to give the amino acid as a white solid, which was purified by C 18 reverse phase chromatography (extracted with water), and the fractions containing the expected product were collected Freeze-dried to give 5 9 m S (7.4%) amino acid 2 0 6 0 1 Η N MR (CD 3 CD, 3 C 1 0 Μ Η ζ) * δ 6 • 6 0 (bd &gt; 1 Η * J = 1.8 Hz) f 4 0 1 — 3 9 5 (m 1 1 Η) 1 3 • 7 1 — 3 6 0 (m »2 Η) 3 5 0 3 4 2 (m 1 ) 1 This paper is subject to the Chinese National Standard (CNS) Λ4 specification (210X 297 gong) -377-v 42666 3 Λ A7 B7 V. Description of the invention 丨 375) 3. 05-2. 85 (m »2H); 2 -3 9-2. 2 8 Cm- 1 Η); 1. 70-1. 55 (m &gt;2H); 0.95 (t, 3H, J = 7. 5 Η z). Example 7 Trifluoroacetamide 207: a solution of amino acid 206 (59 mg, 〇246mmoJ2) in anhydrous methanol (1.0 mL). After degassing, add Et3N (3 5 ML) under argon, and then add three Methyl fluoroacetate (35i / L) was allowed to stir at room temperature for 1 week. Analysis by 1 H NMR showed that the reaction was 40% complete. The crude reaction product was redissolved in methanol (1.0 mL), methyl trifluoroacetate (1.0 mL) and Et3N (0.5 mL) and stirred at room temperature for 5 days * then concentrated in vacuo and redissolved in 50 % THF / Η 20 (2.0 mL), acidified with .Amberlite IR-120 (H +) acidic resin to PH4, filtered, and concentrated to obtain crude trifluoroacetamidocarboxylic acid, which can be used directly without purification Reactions · Example of printing by the Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs 7 3 Amino acid 208: Make azide 207 (crude obtained from the previous reaction) in THF (2.0 mL) and water (160 # L) The solution was treated with triphenylphosphine (2.5 mg) carried on the polymer at room temperature. After stirring for 20 hours, the polymer was filtered off and washed with methanol. Concentrated in vacuo to obtain a light-colored solid, which was purified by Cle reversed phase chromatography (extracted with water). The paper size is in accordance with Chinese National Standard (CNS) 8 4 (210X297 mm) '-378-426663, A7 B7 5. Description of the invention (376) The fractions containing the expected compound are collected and freeze-dried to obtain 6.9%) of trifluoroacetamidoamino acid 208. 1 Η N M R (D 2 〇 &gt; 3 0 0 MHz): δ 6. 5 9 (b s, 1 Η); mg 4. 4 0-4. 30 (m

4. 2 6 (t, 1 H

J 3. 80 — 3. 6 6 (ni 3. 5 6-3. 4 7 (m 2.96 (bdd, lH; 2. 5 8-2. 4 5 (1. 62 — 1. 5 0 (in 0.89 (

H 1 H); 1 0. 1 H 2 H); 1 H); J = 5. 4, 1 H); 2 H); 7.5Hz 7.7Hz Methanesulfonyl methyl ester 209: Add sulfonyl chloride (19 // L) to 0 ° C amine 205 (58mg, 0.23mmoj ?, prepared from Example 107), Et3N (97yL) and catalytic amount DMAP (Several crystals) CH2Cj? 2 (1.0 mL) solution. After 30 minutes, the reaction mixture was allowed to warm to room temperature and stirred for another 1 hour, and concentrated in vacuo. The residue was subjected to flash chromatography on silica gel (50% hexane / ethyl acetate) to give 61 mg (79%) of sulfonamide 209. . 1 H NMR (CDC13, 300MΗζ): δ 6. 87 (t'lH-J = 2. 3 Η ζ); 5. 08 (d, lH, J = 7. 5 Η ζ); This paper size applies to China Standard soap (CNS) A4 specification (210X29? Mm) Printed by the Consumers' Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs 379 4 266 6 3 ^ A7 B7 V. Description of the invention (377) 4. 0 3-3. 9 0 ( m 3. 7 8 (s, 3 Η); 3. 7 5 — 3. 45 (m 3. 1 4 (s, 3 Η); 2. 9 5 (dd-1 H ·

H 4 H); 7

H

.2 2. 4 2 —2, 3 0 (m, '1 H): 1. 7 5 -1. 5 5 (m 1 2' 2 H); 0.9 5 C t, 3 Η, J =- -7 5 H (Please read the precautions on the back, and then ί /% ·-this page). Installation · Example 7 The printed wood paper standard of the staff consumer cooperative of the Central Standards Bureau of the Ministry of Gland Economics applies the Chinese National Standard (CNS) Α3 specifications ( 4 51〇 × 297 mm} -380-380 1 Amino ester 210: A solution of azide 209 (61 mg, 0.183 mm 2) in THF (2.0 mL) and water (118 eL) at room temperature It was treated with triphenylphosphine (170 mg) supported on the polymer and stirred for 17.5 hours. The polymer was filtered off and washed with methanol. After vacuum concentration, the residue was passed through a short silica gel column (100% methanol). Flash chromatography gave 45 mg (80%) of light-colored foamed amine ester 2 1 0. 2 H NMR (CDC13 · 300ΜΗζ): δ 3 3. 2 5-3. 15 (m * 1 Η) : 4 6. 8 5 (s, 1 Η); 3. 94 (bd, lH, J = 7. 8 Η ζ); 5. 7 7 (s * 3 Η); 3. 7 4-3. 6 〇 (m * 2 Η); 3. 55 — 3. 4 5 Cm- 1 Η): / i 2 6 6 6 3 A7 B7 V. Description of the invention (378) s, 3 Η); 94 — 2. 85 (m 3. 1 1 2. 9 4 2 852. 221. 70

2. 1 〇 (m 1. 5 6 (m Ο 9 4 (t, 3 Η, J 1 Η 1 Η 2 Η 7. 实例 Example of printing by the Consumer Cooperatives of the Staff of the Central Standards Bureau of the Ministry of Economic Affairs 7 6 Amino acid 211: Order Methyl ester 210 (21 mg, 0.069 mm) in THF (200 μL) was treated with an aqueous solution of KOH (135 kernel L, 1.039 N). The reaction mixture was stirred at room temperature for 40 minutes, and Araberlite IR- Neutralize 120 (H +) acidic resin to pH 7.0, filter out the resin, wash with water and methanol * concentrate in vacuo to obtain a light-colored solid amino acid, collect with C18 reverse phase chromatography (extracted with water), and collect The fraction containing the expected product was freeze-dried to give 3.5 mg (17%) of amino acid 211. 1 H NMR (D20-300MHz): δ 6. 60 (d, 1H, J = 1.8 8 ζ): 4. 3 0-4. 3. 8 4-3. 3. 6 8 — 3. 3. 6 0-3. 3. 2 0 (s, 2. 9 6-2. 2 0 (m 7 5 (m 5 8 (m 4 0 (m 3 H); 8 8 (m 1 H) 1 H) 1 H) 2 H) 1 H) This paper size applies the Chinese National Standard (CNS) M specification (210X 297 mm)- --------- 1 ------? Τ ------ ^ (Please read the precautions on the back before 4? '1; 4 pages) -381 — 4 ^ 6663 A7 B7 Consumer Cooperatives of Central Bureau of Standards, Ministry of Economic Affairs Fifth, the description of the invention i 379) 2. 55 — 2 · 4 5 (m * 1 Η): 1. 7 2-1. 5 9 Cm- 2 Η); 0.93 (t, 3H, J = 7.4Hz ) Example 7 7 Dione B oc guanidyl ester 2 12: According to Kim and Qian, Tetrahedron Lett. ^ 34: 7 6 7 7 (19 9 3) steps * HgCJ22 (30 mg, 0.1 lmmoj?)-0 ° (: amine 21〇 (31111 &amp;, 0.11 mm ο ^), di-Boc thiourea (28.5mg, 0. 103mmoJ?) and Et3N (47jkL) anhydrous DMF (203 # L) solution. The non-sentence phase reaction mixture was stirred for 3 o minutes, then stirred at room temperature for another 30 minutes, then diluted with et OA c, and filtered through a pad of celite. Concentrated in vacuo, Flash chromatography of the residue on silica gel (40% hexane / ethyl acetate) gave 49 mg (89%) of 212 〇1 H NMR (CDC13. 300MHz) as a light oil: δ 11- 4 7 (s * 1 Η); 8 · 66 (d 'lH * J = 8.4 Hz); 6-87 (s * lH); 6.〇lCbs »lH); 4. 5 0 — 4. 35 (m, lH) 4 〇4 (bd, 1H, J = 8.4 Hz): 3 · 7 6 (s, 3 H); 3 · 7 0-3. 6 0 (m &gt; 1 H); The paper size is universal ten countries. Standard (CNS) A4 size (21 OX 297 male αΊ (Please read the back first Note on item f above ^ ν ^ this page): Packing. Gland · -382-4 266 6 3 Λ π Β7 Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs 5. Description of the invention (380) 3 5 3 1 3 4 5 (m &gt; 2 Η) 3 .0 2 (S 3 Η) 2 .8 5 (dd »1 Η j = 5-3» 1 7-3 Η Z) t 2 .4 2 — 2-3 0 (m redundant 1 Η) 1. 6 6 — 1-5 5 (m 9 2 Η) 1. 4 9 (S ♦ 9 Η) 1 4 8 (S 9 9 Η) 0. 9 3 (t 9 3 Η &gt; j = 7 • 3 Η Z) ο Example 7 8 Carboxylic acid 2 1 3 · K 0 Η aqueous solution (2 6 0 β L 1 0 3 9 N) was added to the methyl ester 2 1 2 (4 9 mg 0 0 9 0 mm 0 ΤΗF (1.0 m L) solution 0 The reaction mixture was stirred at room temperature for 16 hours and cooled to 0 ° C * Amber 1 i te IR-120 (Η +) acid resin was acidified to ρΗ4 () 1 Filter out the resin and wash with water and methanol. Concentrate in vacuum Td * to produce a light-colored foamy white acid, which is used directly in the next reaction without purification. Example 7 9 Guanidinecarboxylic acid 2 1 4 Pure trigas 5TWX acetic acid (2-0 m L) was added to 0 V bis — B 0 C guanidine acid 2 1 3 (to obtain the crude product of the previous reaction) C Η 2C j: 2 (20 m L) solution. Allow the reaction mixture to stir at 0 ° C for 1 hour and then at room temperature for 1 hour. Concentrate in vacuo to obtain a light orange solid. * C 1 S reverse phase layer Analytical (extracted with water) purified and collected fractions containing the expected compounds were freeze-dried to obtain 10 mg (25% 2) This paper size applies to Chinese national standards (CNS &gt; Λ4 specifications (2 丨 〇 × 297 mm) -383- 426663 A7 B7 V. Description of the invention (381) Step) Guanidinecarboxylic acid 2 1 4 9 1 Η Ν Μ R (D 2〇, 3 D 0 Μ Η Z) δ 6 of 6 0 (bs 1 1 Η) 4 2 2 (bd 1 Η i J = 9 0 Η AZ) 3 8 2 — 3 6 6 cm 9 2 Η) I 3 6 5 — 3 5 4 (m) 1 Η) »3 4 3 (bt» 1 Η J = 9 9 Η Z) t 3 1 5 (s &gt; 3 Η) 2 8 2 (dd 1 Η ϊ J = 5 0 1 7 5 HZ) t 2 4 8 — 2 3 0 (m »1 Η) * 1 7 1 — 1 * 5 8 (m 2 Η) · 0 * 9 3. (T 3 Η j = 7 3 Η ζ) 0 Example 8 0 Propylamine methyl ester 2 1 5 Add propionyl chloride (9 6 β L 1 1 mm 0) Amine to 0 ° c 2 5 c 1 7 8 mg 0 7 0 mm 0 k »made from Example 1 7) c c 2 ci; 2 (2 0 in L) and pyridine (1 5 m L) Solution 1 was concentrated at 0 ° C for 30 minutes, and then distributed in ethyl acetate and brine. The organic layer was separated, washed with saturated bicarbonate brine and dried sequentially (MG 4), and the residue was concentrated in vacuo. Flash chromatography on silica gel (40% hexane / Et 0 AC) gave 186 mg (86%) of propylammonium methyl ester as a pale yellow solid 2 1 5 ο 1 Η N MR (CDC 1 3 1 3 C 1 〇Μ Η 5) δ Buy this paper to apply the Chinese National Standard {CMS) Λ4 Specifications (210X 297mm) Please read the notes on the back again Ό -384-

A 426663 A7 _B7_ V. Description of the invention (382) 6. 86 (t, lH, J = 2. 3 Η z) .; 5. 72 (bd, lH, J = 7. 8 Η z): 4. 5 2 -4. 4 9 (m * 1 H); 4. 2 5-4. 15 (m &gt; 1 H); 3. 7 7 (s, 3 H); 3.6 6-3. 38 (complex 111 , 311); 2. 87 (dd-lH-J = 5.7, 17. 7 H z); 2. 28 (q-2H-J = 7. 5 H z); 2. 25 — 2. 2 0 (m &gt; 1 H); 1. 6 5-1. 5 0 (m * 2 H); 1.19 (t, 3H, J = 7.5Hz); 0.92 (t, 3H, J = 7.5Hz). Example 8 1 Amino methyl ester 216: Let azide 215 (186 mg, 0.60 mmoJ?) In THF (5.0 mL) and water (4 0 Ο # 0 L in the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs) The solution was treated with triphenylphosphine (560 mg) carried on the polymer at room temperature, and after stirring for 21 hours, the polymer was filtered off and washed with methanol. Concentration in vacuo gave the crude amine ester 2 1 6 which was used directly in the next reaction without purification. Example 8 2 Amino acid 217: Make methyl 216 (crude from the previous reaction) in THF (500 / iL) solution with KOH solution (this paper size applies Chinese National Standard (CNS) Λ4 specification (210X297煃) -385-42666 3 4 A7 B7 V. Description of the invention (Continent 3) 8 6 6 β L 9 1 • 0 3 9 Ν) Treatment &gt; The reaction mixture was stirred at room temperature for 3 hours &gt; with Ambe! Γ 1 ite IR-1 20 (Η +) acid resin was neutralized to P Η 7 • 0 e. The resin was dripped out and washed with water and methanol. Concentrated in vacuo to give the amino acid as a light-colored solid, which was purified by C 1 8 reverse phase chromatography (extracted with water). Fractions containing the expected product were collected and freeze-dried to give 4 9 mg (3 1% »2 Steps) Amino acid 2 17 ο 1 Η NM MR (D 2 * 0, 3 0 丨 0 Μ Η Z): δ 6 * 5 4 (S f 1 Η) • 4-2 5 (bd &gt; 1 Η, J = 8 7 H j!); 4 · _ 1 3 (dd 9 1 Η, J ^ 9 • 0 •] 1 1. 3 Η z) Lei 3-7 4 — 3 • 6 0 (m, 1 Η) 1 3-6 1-3 4 0 (m &gt; 2 Η) t 2 8 5 (ddj 1 Η, J = 5 g,] .7. 1 Η z) (Please read the precautions on the back before ^ ^ This page)-binding-binding; 2. 55 — 2 .. 4 0 (m »1 Η); 2-3 5 (Q 9 2 Η J = 7. 5 Η ZO); 1-6 5 1 1 • 4 5 (m, 2 Η) 1 1 • 1 3 C t &gt; 3 Η j = 7.5. 5 Η ZO); Warp -k 0 * 8 8 (t 3 Η j = 7.5. 5 Η ZO) 0 t Standard Bureau Example 8 3 Staff Consumption (monomethyl) di-B 0 C guanidyl ester 2 1 8: under chamber fun, will be 1- (3-methylaminopropyl)-3 -ethylcarbodiimide salt (in%) 3 8 m S) and E ta IN; 5 6 w L) added to the amine 2 0 0 (5 1 mg * 0 * 1 9 mm 0 J2) and monomethyldi-B 〇C thiourea (the size of this paper is suitable Cai Guan Xu Zhun (CNS) Eight 4 Na (210x7 ^^ 7 -386-^ ^ 66 6 3) Α7 _____ Β7 ___ V. Description of the invention (Qi 4) 36mg, 0.19mmoJ?) Anhydrous DMF (1. OmL) Solution. After 1.5 hours at room temperature, HgCj2 (about 75 mg, excess) was added in one portion. The heterogeneous reaction mixture was allowed to stir for 45 minutes, diluted with ethyl acetate, and filtered through a pad of celite. The filtrate was diluted with additional ethyl acetate, washed with dilute Hc, saturated sodium bicarbonate, brine, dried (MgS04), and concentrated in vacuo. The residue was printed on the Shellfish Consumer Cooperative of the Central Standards Bureau of the Ministry of Silicon Economics (10% Μ e 0 H / E t 0 A c). 3 m S (16%) ιΛτ ^ was obtained by fast chromatography. Foam shape: of (monomethyl) di-B 0 c-based ester 2 1 8 0 Η N MR (c DC 1 3 »3 0 0 MHZ): δ 6 • 8 4 (s ♦ 1 H)« 6 2 0 (bd 1 1 H sj = 5 1 H z); 5-4 5 (bs ♦ 1 H) »4-2 5 — 4 4 0 (bm I 1 H) t 4 2 0 — 4 * 0 5 ( bm &gt; 2 H) 1 3 * 7 6 (s * 3 H) &gt; 3-6 0 — 3 * 5 0 (m 7 1 H) t 3 • 4 3 — 3 3 0 (mt 1 H) • 2 * 9 0 (ddt 1 H »J — 5-4 i 1 7.7 Η) 2 * 7 7 (d» 3 H »j = 4-8 H z) r 2 * 3 5 — 2 * 2 5 (mt 1 H) »1 9 6 (sf 3 H) 1 1 6 0 — 1 5 0 (m 2 H) 1 4 7 (s» 9 H) »This paper size applies to China National Standard (CNS) Λ4 specification (2 〖〇X 297mm} -387-A7 B7 V. Description of the invention (385) 〇-91 (t, 3H, J = 7.2Hz) (Please read first Read the notes on the back again ^ &quot; This page) Tube R 4 (monomethyl) di_Boc guanidino 219: Add KOH aqueous solution (60jwL, 1.039N) to methyl ester 218 (13mg, 〇 · 031mmo 芡) in THF (500 # L) solution • Allow the reaction mixture to stir at room temperature for 1 hour, then gently reflux for 1 hour, cool to 0 C, and acidify with Amberlite IR-120 (H +) acid resin to PH 6.0. The resin was filtered off and washed with water and methanol. Concentration in vacuo gave the free acid 2 1 9 which can be used directly in the next reaction without purification. Example 8 5 (monomethyl) guanidoamino acid 2 2 0. Add pure trifluoroacetic acid (1.0 mL) to CH2CJ? 2 of (monomethyl) _di-Boc guanidinic acid 219 (crude from the previous reaction) (printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs 1 OmL) solution. The reaction mixture was allowed to stir at 0 ° C for 1 hour and then at room temperature for 1 hour. Concentrated in vacuo to obtain a light-colored solid, purified by C18 reverse phase chromatography (extracted with water), collected fractions containing the expected product, and freeze-dried to give 4. 4111 ^ (33%, 2 steps) guanidinocarboxylic acid 2 2 0. 1 H NMR (D20 · 300MHz): δ 6. 5 2 (bs · 1 Η); 4. 27 (bd, lH, J = 8- 4Hz); This paper size applies the Chinese National Standard (CNS) Α4 specification (210 × 297 Mm) —388 — 4 2 66 6 3 (A? ______B7___ V. Description of the invention (386). 4. 01 (dd, lH, J = 9.2, 10.3 Η z); 3. 8 6-3 7 5 (m-1 Η); 3.75 — 3. 6 7 (m * 1 Η); 3.60 — 3.49 (m, lH); 2. 8 5 (s &gt; 3 Η): 2. 80 ( dd * lH &gt; J = 5. 1 * 17. 7 H z); 2. 4 7-2. 3 7 Cm · 1 H); 2. 0 4 (s, 3 H); 1.6 4-1. 5 0 (m * 2 H); 0.90 (t, 3H, J = 7.2 Hz). Tube Example 8 fi (R) -methylpropyl ester 2 2 1: BF3 · Et30 (63iiL, 0 51mm〇i?) Was added to trityl aziridine 183 ( 150mg, printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs (341) (n)-(-)-2 -butanol (1.2mL) solution. The light-colored solution was heated to 70 ^ for 2 hours, and then concentrated in vacuo to obtain a brown residue. * It was dissolved in anhydrous pyridine (2.0 mL), and acetic anhydride (225iiL) and a catalytic amount of DMA were dissolved at 0 ° C. Treat with P (a few crystals), allow the reaction to warm to room temperature and stir for 2 hours, concentrate in vacuo, and distribute the organic layer in ethyl acetate and brine to separate the organic layer, and wash with dilute HCj ?, saturated sodium bicarbonate, and brine in sequence. After drying (Mg S04), the residue was concentrated on silica gel (50% hexane / ethyl acetate) and flash chromatography was performed to obtain 75 mg (72%) of a light-colored solid. CNS) A4 specification (2 × 4 × 7 mm) -389-4 2 B 6 6 3; * A7 B7 Printing by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs 5. Description of the invention (387) 1 I (R) — Methylpropyl ester 2 2 1 0 1 |] Η NMR (CDC 1 3 1 3 0 0 Μ Η-Zn 5 1 1 6. 7 9 (t 9 1 HJ = 2 2 Η Z) 1 1 first 1 6 1 4 (d »1 H» J = 7-3 Η Z) &gt; Read 1 4 5 5 (bd 1 HJ = 8 7 Η Z) back 1 I No. 1 Note 1 4-3 3 — 4 2 3 (m 1 Η) Meaning 1 3 7 7 (s »3 H) Then 1 3 5 6 3 4 5 (m 1 Η) Γ) Book 1 Page 1 3 4 0 — 3 2 7 (m 1 Η) 1 I 2 8 5 (ddt 1 H 1 J = 5 5 1 7 .5 Hz)] 1 | 2 3 0 — 2 1 5 (m 1 Η) I 1 order 2 0 4 (s 3 H) * 1 1 5 9 0 1 4 0 C m 2))% 1 1 1 1 0 (d 3 H j — 6 0 Η ZO) 1 1 0-9 1 (t 3 H j = 7 + 4 Η Zn) 0 1 1 Example 8 7 1! (R) —Methylpropylamino ester 2 2 2; P h 3P (95 1 mg 0 3 6 mm 0 ίί) * ~~-times Add azide 2 2 1 (1 1 7 5 mg 9 0-2 4 mm 0) water (4 3 2 μ L), 1 1 T Η F (30 m L) solution ο this light yellow solution It was heated at 1 I 5 0 ° C for 10 hours. After cooling, it was concentrated in vacuo to give a light-colored solid. Purified with I 1 silica gel (50% Me 0 Η / Ε 0 AC) by flash chromatography to obtain 1 out of 66 ms (97%) amine ester as a light-colored solid 2 2 2 〇 This paper size is applicable China National Standards (CNS) Λ4 (2 [OX 297 mm) -390-A7 B7 426663 V. Description of the invention (388) Example 8 8 Amino acid 223: methyl ester 222 (34mg, 0.12mmoj2 ) In THF (1, 0 mL) was treated with an aqueous KOH solution (175 // L, 1.039N). After the reaction mixture was stirred at room temperature for 3 hours, it was acidified with Amberlite IR-120 (H +) acidic resin to pH 6.0. The resin was filtered off, washed with water and methanol, and concentrated in vacuo to obtain a light colored solid amino acid. Purified by C18 reverse phase chromatography (extracted with water). The fractions containing the expected product were collected and freeze-dried to give 11.5MG (36%) amino acid 223. 1 H NMR (D20 &gt; 300MHz): δ 6. 52 (bs-lH); Please read the precautions before reading 4. 2 8 (bd, 1 Η 4. 0 4 (dd, 1 Η 3. 7 4-3. 6 5 (

J 8.7Hz Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs 2 2 2 0

5 0-3. 6 0 (9 0 (d d-1 H 5 0-2. 4 0 (m 10 H) 6 0-1. 4 5 (1 4 (d 9 1 (t

3 H 3 H 8. H) H) 5. H) 8

H 5 7

2 H 2 H); 6. 2 H z) 7. 4 H z) Window example 8 9 This paper size applies to Chinese National Standard (CNS) / \ 4 current grid (210 X 29 &quot; 7 mm) -391-4 2 66 6 3 4 A7 B7 Printed by the Central Ladder and Shellfish Consumer Cooperative of the Ministry of Economic Affairs. 5. Description of the invention (389) 1 I — one B 0 C guanidyl ester 2 2 4 According to Kim and Q i an, ** 1 1 I Tetrahedron Lett • y 34: 7677 (1 993). Add 1 i 1 H g C J2 2 (3 4 mg, 3 · 1 2 5 mi mo _β) at a time to ι 1 Please t 〇 ° C of amine 2 2 2 (3 2 mg 9 0.1 .1 13 mm 〇 5), two first read 1 1 read 1 1 -B Ο C thiourea (3 2 mg 0 _ 11 5 mmoj?) And 1 I 1 E t 3N (5 3 ah) on the back of anhydrous DMF (3 5 0 # L) Solution Attention 1 1 Things 1 Stir the heterogeneous reaction mixture at 0 ° C for 4 5 minutes, and then stir at room temperature for 1 hour »Then dilute with E t 0 Ac and then diatom Soil pad P Ben 1 Pack 1 Filter 0 The residue was concentrated by vacuum chromatography on silica gel (20% hexane / ethyl acetate VW &lt; · 1 1) to give 5 7 mg (96%) colorless foam. 1 1 I 2 2 4 0 1 1 1 Η N MR (CDC 1 3 * 3 C) 0 M] Η z) ： &lt; 5 Order 1 1 1-4 0 (S 1 1 H) 1 1 8- 6 5 (d »1 H» J = 7.8 h ζ): ί 1 6 8 2 (S 1 H) t I line 6-3 6 (dy 1 HJ 8 .7 Η AZ): I ί 4 4 6 -4 3 4 (m 1 H) 1 [4 2 0 -4 1 0 (m 1 H) 1 1 4 1 0-3 9 5 (m 1 H) [1 3-7 6 (s $ 3 H) 1 1 I 2 * 7 9 (dd &gt; 1 H t J 5. 4 * 17. 7 Η ζ) 1 j; 2 4 7 _ 2 * 3 5 (m 1 H) * 1 1 I 1-9 3 (s 3 H) r 1 1 I 1 * 6 0 —1 * 4 5 (m 2 H) t 1 1 This paper size applies to Chinese National Standard (CNS) Λ4 specification (210X2M mm) -392 A7 B7 426663 V. Description of the invention (390) 1. 49 (s -18H); 1. 13 (d, 3H, J6. OHz); 0.91 (t, 3H, J = 7.5Hz). Example 9 0 Carboxylic acid 225: A solution of K0Η in water (212 kernels L, 1. 039N) was added to a solution of methyl ester 224 (57 mg, 0.1 mmmoj?) In THF (1.5 mL). 0。 The reaction mixture was allowed to stir at room temperature for 16.6 hours, cooled to 0 ° C, acidified with Amberlite IR-120CH +) acid resin to pH 4.0. The filtered resin * was washed with water and methanol. Concentrated in vacuo to give a light foamy free acid. It was used directly in the next reaction without purification. Example 9 1 Guanidinecarboxylic acid 226: CH3C52 (4 crude fluoroacetic acid (4.0 mL)) was added to 0 ° C bis β guanidine acid 2 2 (from the crude product of the previous reaction) OmL) solution "let the reaction mixture at 0x: stir for 1 hour, and then stir at room temperature for 2 hours; concentrated in vacuo to give a light orange solid * purified by C18 reverse phase chromatography (water extraction), collected containing the expected product The fraction was freeze-dried to obtain 18.4 mg (40% '2 steps) of guanidinecarboxylic acid 2 2 6 »1 H NMR (D20 * 300MHz): &lt; 5 6. 4 7 (s · 1 Η); 4. 28 (bd, lH, J = 8. 4 Η ζ); k paper size adopts Chinese National Standard (CNS) A4 specification (21〇 × 297 mm) ~ i!. 装.,-A} ^. . (Please read the notes on the back first, then this page) Printed by the Shellfish Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs-4 266 6 3 'A7 __B7 V. Description of the Invention (391) Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs 3 * 9 3 — 3 * 7 4 (m &gt; 2 Η); 3-7 2 — 3 * 6 3 (my 1 Η) 2 7 8 (dd »1 Η» J 4 8 * 1 7 4 Η Z ) &gt; 2 4 3 — 2 • 3 2 (m &gt; 1 Η) * 1 • 5 8 — 1 4 5 (m 2 Η) * &gt; 1-1 3 (d 3 Η 9 j = 6 0 Η Z) * 0 • 9 0 (t 1 3 Η »j = 7-4 Η Z) 0-Example 9 2 (Diethyl) methyl ether ester 2 2 7; Add BF 3 Eta 0 (6 2 7 m L »5 1 mm 0 SL) to N-benzyl under agitation at room temperature. Μ, propidium 1 8 3 (1 5 S »3 4 mm 0) in 3 monopentyl alcohol (2 30 m L) solution o Let this light solution be heated at 70 0 7 5 ° C for 1 5 5 hours y Concentrated in vacuum to re-dissolve the color-sweeping residue and re-dissolve it in anhydrous Dtt (20 m L). * Acetic anhydride (16 m L 9 1 7 0 ΠΊ m 0 9.) 2 0 0 m S) treatment. The reaction should be stirred at room temperature for 18 hours &gt; concentrated in vacuo and distributed in ethyl acetate chit and 1 M H c 9. Separate the organic layer 9 sequentially with saturated carbonic acid Wash and dry with sodium hydrogen chloride (M g S 0 after concentration & ► Residue in silica gel (50% hexane / ethyl acetate) ) On the flash chromatography to get 7 • 6 6 S (diethyl) methyl ether ester • white ethyl acetate / recrystallized from hexane to give jhrr. Tear-off needle 2 2 7 (7-2 5 g 9 6 6 %) 〇1 Η N MR (CDC 1 3 1 3 (] C) Μ Η; Ϊ); δ 6 7 9 (t 9 1 Η 1 J = 2 1 Η Z) 1 This paper size applies to Chinese national standards ( CNS) 8 specifications (210X297) ((Please read the precautions on the back ^ &quot; 'This page) • Binding · Binding 426663 A7 B7 V. Description of the invention (392) 5. 9 2 (d 9 1 H * J = 7 5 H z) 4. 5 8 (bd »1 H» J = 8 7 H 2 4. 3 5 — 4 2 (m 1 H) = 3. 7 7 (s 3 H) »3-3 6 — 3 2 5 (m 2 H) t 2. 8 5 (dd »1 H j J — 5 7, 1 2. 2 9 — 2 1 8 (mt 1 H)» 2. 0 4 (s &gt; 3 H ), 1. 6 0 — 1-4 5 (mi 4 H) t 0. 9 1 (t 3 HJ = 3 • 7 HZ) 0. 9 0 (t &gt; 3 H »J = 7 3 HZ) 7 4Hz Please read the precautions on the back first, and then "Bound Booklet Example 9 3 (Diethyl) methyl ether amino ester 228: Ph3P (1.21g, 4.6 mmoJ?)-A solution of degassed product 227 (lg, 3. lmmo £), water (5.6 mL) and THF (30 mL) was added at a time. The pale yellow solution was then heated at 50 ° C for 10 hours, cooled and concentrated in vacuo. The watery oily residue was distributed in EtoAc and saturated NaCiZ. The organic layer was dried (M g S 0 4), filtered and evaporated to dryness. Flash chromatography on silica gel (50% methanol / ethyl acetate) yielded 830 mg (90%) of amine ester 2 2 8 as a light white solid. 1 H NMR (CDC13, 300MHz): δ 6. 78 (t, lH, J = 2. 1 Η ζ); This paper size applies the Chinese National Standard (CNS) A4 specification (210X297 mm)) Central Standard of the Ministry of Economics Printed by Bureau Staff Consumer Cooperatives -395-426663

A A7 B7 Printed by the Shellfish Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs 5. Description of Invention (393) 5 6 8 (bd »1 Η 9 J = 7 • 8 Η ZO); 4 2 1 — 4 1 8 cmv 1 H) t 3 • 7 5 (S 1 3 Η) * 3-5 4 — 3 4 5 (m »1 H) • 3 3 7 — 3 • 1 5 (m 9 2 H) t 2 • 7 4 (dd» 1 Η * 3 — 5 • 1 ♦ 1 7.7 Hz), 2 2 0 — 2 0 7 (m 1 1 H) r 2 0 3 (sj 3 Η) 1 6 9 (bs * 2 Η y — NH 2) 1 • 5 7 — 1 * 4 4 (m 9 4 H) 0 9 0 (t * 3 Η 9 j = 7 5 Η ζ) 1 0-8 9 (t 9 3 Η yj = 7 • 5 Η ζ) 〇 Example 9 4 Amino Acid 2 2 9 Methyl Ester 2 2 8 (8 30 mg * 2 • 8 mm 0) in T F (15 m L) solution with K OH aqueous solution (4 m L * 1 0 3 9 N) Treatment ο Allow the reaction mixture to stir at room temperature for 40 minutes I acidify with Dowex 50WX8 acid resin to P Ρ 5-5-6 0 9 Filter out the resin i and wash with water and methanol. Concentrated in vacuo to give the amino acid f as a light-colored solid. Reverse phase chromatography with C IS (extracted with water »then 5% C Η 3 CN / water) Purification 1 | Collect fractions containing expected product * freeze-dried This gives 6 0 0 m S (75%) amino acid (please read the notes on the back before Ci page)-binding-order 2 2 9. 1 H NMR (D2. 300MHz): &lt; 5 This paper size is applicable to Chinese National Standard (CNS) Λ4 specification (210X297) and -396-266 6 3; · A7 B7 V. Description of the invention (394) 2 2 6 2 -1. 4 Ο (m 0. 9 0 (t, 3 H, J = 7 0. 8 5 (t, 3 H, J = 7 1 Η 4 Η 8 8 (dd, 1 Η, 5 3-2. 41 (m);): 5 Η ζ); 5 Η ζ) »6. 5 0 (t, 1 Η, J = 2 1 Hz) .: 4. 3 0 — 4 .2 6 (m, 1 H) t 4. 0 3 (dd, 1 Η, J = 9 • 0, 1 1. 7 Η i ϊ) 3. 5 8 3. 4 8 (m, 2 H) r • 4, 1 6 · 8 部 Ministry of Economic Affairs Central Standards Bureau Shelley Consumer Cooperative Printing Tube Example 9 5 Tertiary amyl ether ester 23 〇: Add BF3 · Et2〇 (43 RenL, 0.35mmo) 2) to argon under stirring at room temperature N_trityl aziridine 183 (104mg, 0.24mmo $) in a solution of tertiary pentanol (2.5 mL). This light solution was heated at 7 5 ° C for 3 hours, and concentrated in vacuo to give a brown color The residue was dissolved in anhydrous pyridine (2.0 mL) and treated with acetic anhydride (250iiL) and a catalytic amount of DMAP (several crystals). The reaction was allowed to stir at room temperature for 1.5 hours. After concentration in vacuo, Cloth in ethyl acetate and brine. The organic layer was separated, washed with dilute HCj ?, saturated sodium bicarbonate, brine, dried (Mg S04), and concentrated. The residue was in silica gel (50% hexane / ethyl acetate). (27) (3 5%) of the third pentyl ether ester 2 3 0 as a light orange oil. 1 H NMR (CDCla-300MHz): δ This paper is in accordance with the Chinese national standard (cns &gt; μ present case (2i × χ297 mm) 397 4266 6 3 A7 B7 V. Description of the invention (Brief 5) 6. 72 (t &gt; lH-J = 2. 1 Η z); 5. 83 (d, lH, J = 7. 2 Η z); 4. 71 (bd, lH, J = 8. 1 Η z): 4. 4 5-4. 3 5 Cm- 1 H); 3. 7 5 (s-3 H ); 3. 2 7-3. 17 (m, lH); 2. 84 (dd, lH, J = 5. 7, 17. 4 H z); 2. 2 7-2. 15 (m-1 H ); 2.05 (s * 3H); 1.57 — 1.47 (m, 2H): 1. 19 (s, 3H); 1. 15 (s, 3H); 0.90 (t, 3H, J = 7.5Hz ). Example 9 6 Third pentyl ether amino ester 231: Ph3P (35nig, 0.133mm) was added to azide 230 (printed by the Consumer Cooperative of the Central Bureau of Standards, Ministry of Economic Affairs, 27 mg * 0. 083 mm), in a solution of water (160 μL) and THF (1.5 mL). This light orange solution was heated at 50 ° C for 10 hours. After cooling, it was concentrated in vacuo to give a light-colored solid. Flash chromatography on silica gel (50% MeOH / EtOAc) gave 20 mg (82%) of amine 231 as a light oil. Example 9 7 Amino acid 232: Methyl ester 231 (20m g, this paper size applies Chinese National Standard (CNS) A4 specification (21〇 &gt; &lt; 297mm) * -398-426663 A7 B7 V. Invention Explanation (396) 〇.〇68mm〇i?) In THF (1. OrnL) solution was treated with KOH aqueous solution (131eL, 1.039N) • The reaction mixture was allowed to stir at room temperature for 2.5 hours, and then Amber lite IR-120 (H +) acidic resin was acidified to ρ Η 5 · 〇 »The resin was filtered off and washed with water and methanol. Concentrated in vacuo to give the amino acid as a light-colored solid, which was purified by C18 reverse phase chromatography (extracted with water), and the fractions containing the expected product were collected and freeze-dried to give 8.6 mg (45%) of aminoamine 232. 1 H NMR (D20 * 300MHz) 'δ 6. 4 7 (bs * 1 Η); 4. 42 (bd, lH, J = 8.1 Hz); 3. 97 (dd &gt; lH * J = 8.4, 11.4 H z); 3.65-3. 54 (m, lH); 2. 88 (dd-1H * J = 5.5, 17.3Hz) 2.5 .1-2. .3 9 (Ώ 1 * 1 )) 2. 0 8 (s, 3 Η) 9 1.61 -1 .4 6 (m 1 2 Η); 2 3 (s 8 6 (t

3 H 3 H 1 8 (s .5 H z 3 H); example of the seal of the consumer cooperative of employees of the Central Bureau of Standards of the Ministry of Economic Affairs 9 8 n-Resyl sulfide ester 2 3 3: Argon and room temperature, stirring O t20 (13.0 夂 L, 1..06mino ^) was added to a solution of N-trityl aziridine 1 83 (300 mg, 0.68 mmoJ?) In 1-propanethiol (8.0 mL) Chinese and private paper standards General Chinese National Standard (CNS) A4 specification (210X297 male f) -399 426663, B7 Printing by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs 5. Description of the invention (397) ° C heated for 4 5 minutes, concentrated and distributed in ethyl acetate and brine. The organic layer was separated and separated. 1 Washed with saturated carbon: sodium bicarbonate t brine, dried (MS s 0 and concentrated. The residue was concentrated in silicone (3 0% hexane / ethyl acetate) flash chromatography on 134 m S (73%) n-propyl sulfide ester as light oil 〇1 1 Ν ΜR (c DC 1 3, 3 0 0 Μ Η z): &lt; 5 6 .8 7 (tt 1 Η 9 J = 2 4 Hz) 3 -7 7 (S 3 Η 0 f 3 .4 8-3 * 3 8 (m »1 Η) V 3 .2 2 — 3 • 1 8 (m 1 Η) 2 .9 3 (dd 1 Η * J = 5 • 4, 1 7 ► 4 Η Z); 2.8 0 (t * 1 Η j = 9 9 Hz) »2 .5 1 (t» 2 Η »j 7 • 2 Hz) 1 2 .3 2 — 2 2 0 (mt 1 Η) * 1 .9 6 (b S 9 2 Η — N Η 2) 1 .6 9 — 1-5 6 (m 9 2 Η) • 1. 0 0 (t »3 Η tj port 7 * 2 Hz) 0 ΛΜ.』 9 n-propyl sulfide Azide 2 3 4 0 ° C Add pure acetamidine (60 β L &gt; 0-8 4 mmo) to the pyridine of amine 2 3 (1 3 4 m S, 0.5 0 mm 0) The solution was stirred for 15 hours. After the reaction mixture was stirred for 1 hour, the reaction mixture was warmed to room temperature and stirred for 15 minutes. 0 After concentration, it was distributed in ethyl acetate and brine, and then the paper was washed with dilute C 9 water. Standards apply to Chinese National Standards (CNS) Λ4 specifications (21 OX 297 mm) A7 B7 Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs 5. Description of the invention (398) and sodium bicarbonate After washing and drying (MgS0), it was concentrated. The residue was chromatographed on silica gel (30% hexane / ethyl acetate) to give 16 2m S (100%) as a pale yellow solid, n-thyl sulfide azide 2 3 4 〇1 Η N MR (c DC 1 3 &gt; 300 MHz): δ 6. 9 0 (t, 1 Η 9 J = 2. 7 Η 2) &gt; 5. 8 7 C bd 1 1 Η VJ = 7.8 Hz); 4. 0 7 — 3 9 8 (ΙΪ1 1 Η) 9 3. 7 7 (s 9 3 Η) 1 3. 6 5 — 3 • 5 5 (m 1 Η) r 2. 9 5 — 2 * 8 5 (m 1 Η) 2. 6 0 — 2 4 5 (m 2 Η) 2. 3 0 — 2 1 8 (m 1 Η) 2. 0 8 (s 3 Η) 1. 6 5 — 1 5 3 (m 2 Η) 0. 9 8 (t 3 Η j = 7. 2 Η z) ο Example 1 0 0 n-propyl sulfide amino ester 2 3 5: make the derivation compound 2 3 4 (13 0 m g, 0 4 16 mm 0%) in ethyl acetate (10 ml) solution at room temperature with Li η d 1 ar catalyst gasification (1 at ΠΊ) for 18 hours 0 and then filtered through a pad of celite Catalyst * ♦ Use hot ethyl acetate and methyl alcohol After washing with alcohol and concentrating in vacuo, the orange residue was obtained by flash chromatography in 62 ms (53%) n-propyl sulfide amino ester 2 3 5 〇 This paper size applies to Chinese national standards {CNS &gt; Λ4 specifications (210 X 297 mm) -401-4266 6 3 ^ A7 — B7 V. Description of the invention (399) Printed by the Consumers' Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs 11 1 Η NMR (CDC 1 3

6. 8 8 (t, 1 H, J 5. 6 7 (bd, 1 H, 3. 7 6 (s * 3 H); 3. 7 5-3. 6 5 (m 3. 4 5-3. 35 (b 3. 0 5 — 2. 95 (m 2. 87 — 2. 7 8 (m 2. 56-2. 4 0 (m 2. 18-2. 0 5 (m 2. 0 9 (s, 3 H); 1. 6 5-1. 5 0 (m 1. 5 3 (bs, 2 H,

0.98 (t * 3 H, J Example 1 0 1 Compound 240: Let the golden rooster dimethoxypropane (200 m L in acetone (700 m L)) remove the solvent and m reagent .Fast E t 0 AC = 2/1 — 1. (8 4 S 9 7 3%); 1 Η 4 7 2 (dd »J = 2 4 5 0 (m 1 H), -300MHz): δ = 2 7 Η z); J = 8.7 Η z);, 1 Η); m, 1 Η): &gt; 1 Η); • 1 Η);, 2 Η):, 1 Η);, 2 Η ); -N Η 2); = 7.2 Η ζ). A suspension of phthalic acid (103 g) '2 * 2-) and toluenesulfonic acid (850 mg) was stirred at room temperature for 4 days. Purification by reduced-pressure flash column chromatography (hexane / 5/1) yields lactone 240 NMR (CDC AI 3) δ .4, 6. 1 1 z-1 Η), 4. 3 1 Cm * 1 Η) , This paper size applies to Chinese National Standard (.CNS) A4 specification (210X297 mm) A7 B7 426663 V. Description of the invention (1 2 3〇〇) 2.67 (m, 2H), 2. 4 — 2. 2 (m * 3 Η), 1.52 (s * 3H), 1.33 (s, 3H). If the reaction was refluxed for 4 hours, the aqueous layer was isolated and purified (distributed in ethyl acetate / water), and the crude product was recrystallized from ethyl acetate / hexane to yield lactone 24 (yield 71%). Example 1 Π combination 〇 \ 1 / ο 4 times ο Three S take bO and extract Μ C (Α drying ο dry t E times after t, a single release washing dilute water salt washing water layer machine has a secondary delamination column tube 逋 fast alkane Hexanol dihydrate purified ΛΙχ 4 \ to 1 \-CA ο t E \ Printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs% D 1 7— &gt; * &gt; *-&gt; 8 cmt s dm t R / 1 \ r \ / IN fv g M 8 9 2 6 8 4 N 4 9 8 2 o 3 H 4 3 3 2 2 4

J 3 J: n VJ c〇 \ J, οϋ \ 1 / &gt; C Η II Η II Η XI / 3, Zn-N,) * m Η S Η m (1 (2 (3, 4 * 1 1 ζ 3 ζ 9 Η · Η. 4 4 3 8 1 Η) Η 1 XI / Η H 3 s (4 5 V) / Η 3 S C- 8 3 CN / l \ standard standard. Suitable for every country and country One piece of paper ¾ 4 Λ

1 centimeter 7 9 2 X 1 Compound 241: Sodium methoxide (4.37 M, 2 46. 5 mL, 203 mmo 芡) was added to a solution of internal vinegar 240 (3.3. 5 g, 20 30 mm JJ) in methanol (1200 mL) in one portion. The mixture was allowed to stir at room temperature for 3 hours, and the reaction was interrupted with acetic acid (11, 62 mL). The methanol was removed under reduced pressure. The mixture was treated with A7 B7 A26663 V. Description of the invention (400) In addition, if the lactone 240 was treated in ethanol with a catalytic amount of sodium ethoxide (lmoj?%), The crude product was obtained after recrystallization from ethyl acetate / hexane. The corresponding ethyl ester (6 7%) was obtained. The residue obtained from the mother liquor (consisting of the starting material and the product) was treated under the same conditions, and the additional product was obtained after recrystallization. The total yield was 83%. Example 1 0 3 Compound printed by the Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs 2 4 2: p-toluene pours chlorine (2 7 7 S 9 1 4 5 mm 0) to diol 2 4 1 (2 9 8 SI 1 2 1 mm 0) in a solution of pyridine (230 ml) with 4 (N-N-dimethylamino) pyridine (500 ms). The mixture was stirred at room temperature for 3 days to remove the pyridine under reduced pressure. 〇Dilution with water> Extracted three times with Et 0 A c 0 Combined organic layers were washed twice with water and once with brine »dried (Mg S 0 4) and concentrated" &gt; flash column chromatography (hexane / E t 0 A c = 2/1-1/1) p-toluenesulfonate 2 4 2 (4 4-6 s 9 2 %) ο 1 Η NMR (CD c 1 3) δ 7 8 4 (d 1 J 8 4 ζ ζ »2 Η) 7 • 3 3 (d 9 J = 8-1 Η ζ 2 Η) 4 7 6 (mi 1 Η) &gt; 4-4 2 (m 1 Η) 4 0 5 (dd J = 5 5 τ 7-5 Η Zn 1 Η), 3 • 8 0 (s »3 Η) 2 4 4 (s 3 Η ) 2 • 3 5 (m T 1 Η) * 2 2 4 (m 2 Η) 1 * 9 6 (m T 1 Η) 1 1 2 6 (s 3) ) A4 specification (21〇 × 2ί &gt; 7 mm) _ Α (\ Α ~ A7 4 266 6 3, _____B7____ V. Description of the invention (4〇2) 1.1 4 (s, 3 Η). The corresponding ethyl ester of compound 2 41 is at 0 ° C. CH2CJ? 2 * is treated with methanesulfonyl chloride and triethylamine, and purified by isolation to obtain the mesylate derivative (full amount). This mesylate can be used directly without further purification. Example 1 D 4 Compound 243: p-toluenesulfonate 242 (44.6 s-111.5 τηιη〇β) in CH2CjZ2 (450inL) solution was added pyridine (8 9 ml) at 78 ° C, followed by slow addition So2Ci? 2 (26.67 mL, 335 mm). After the mixture was stirred at 78 ° C for 5 hours, methanol (45 mL) was added dropwise, and the mixture was warmed to room temperature and stirred for another 12 hours. After adding ether, it was washed three times with water, once with brine, dried (Mg S 04), and concentrated to give an oily intermediate (44.8 g). TsOHCl. 06g, 5.6mmoJ2) was added to this intermediate (44.8g 'solution of 111. 5mm〇i) printed in a sock of the consumer cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs (MeOH) (500mL), and refluxed for 4 hours. After cooling to room temperature, the methanol was removed under reduced pressure * Fresh methanol (50 OmL) was added, and the mixture was stirred for another 4 hours. After cooling to room temperature, the methanol was removed under reduced pressure. After purification by flash column chromatography (hexane / E t OA c = 3/1-1/3), a mixture of two isomers (26.8 g) was obtained. Recrystallization from EtOAc / hexane gave pure expected product 243 (2 0.5 g '54%) 1 H NMR (CDC 13), δ 7 8 2 (d &gt; J = 8-3 H z-2 H) ， This paper size applies Chinese national standard (CNS M4 specification (2! 〇 &gt; &lt; 297mm) -405-426663 A7 B7 V. Description of the invention &lt; 403) 7-3 7 (d »J = 8. 3Hz , 2H), 6. 8 4 (m * 1 Η) * 4. 8 2 (dd * J = 5.8, 7. 4 Hz, lH), 4. 5 0 (m * 1 H), 3. 9 0 (dd * J = 4.4, 8. 2 H z-1 H), 3. 7 4 (s, 3 H), 2. 79 (dd, J = 5. 5 / 18. 2 H z * 1 H ) 2. 4 2 (dd &gt; J = 6.6, 18. 2 H z &gt; 1 H). The corresponding mesylate monoethyl ester derivative of compound 2 4 2 was treated in the same manner as described. The acetone protecting group was removed by treatment with acetic acid while the acetic acid was refluxed. Since then, the crude reaction mixture was directly precipitated with diethyl ether to obtain a diol (39% yield). Example 1 Π Fi Compound 1: DBU (8.75 m L &gt; Shellfish Consumption Cooperation Printed by the Central Bureau of Standards of the Ministry of Economic Affairs, printed 5.8.5 ιιιη〇ί) was added to diol 243 (20. Og & gt 58.5 mm) in THF (300 mL). The reaction mixture was allowed to warm to room temperature and stirred for 12 hours. The solvent (THF) was removed under reduced pressure. Purification by flash column chromatography (hexane / EtOAc = l / 3) gave epoxide 1 (9.7 2 g &gt; 100%) ·-1 H NMR (CDC 13) δ 6. 7 2 C m-1 Η) &gt; 4. 5 6 (bd &gt; J = 2.6, 10.7Hz, lH) This paper size is applicable to China National Standard (CNS) A4 specification (2 丨 OX mm) ~ &quot; ~ A7 B7 4266 6 3 j V. Description of the invention (404), 3.76 (s, 3H), 3.56 (m &gt; 2 Η), 3.0 (dJ = 21Hz * lH), 2.50 (d, J = 20 Hz, lH), 2.11 (d, 10.9 Hz, lH). The corresponding mesylate monoethyl derivative of compound 2 4 3 was treated in the same manner as described, and an epoxide was obtained in almost full yield. 1Example 1 0 fi Aziridine 244: Allyl ether 4 (223 mg, 1.07 mm) and Lindlar catalyst (20 Omg) in absolute alcohol (8.0 mL), treated with hydrogen (1 atm) at room temperature for 50 minutes. The catalyst was then filtered off with a pad of diatomaceous earth, washed with hot methanol, and concentrated in vacuo to give about 2 3 mg of 2 4 4 as a light yellow oil, which was used in the next reaction without further purification. Example 1 0 7 Mannidylamine 205: Crude aziridine 244 (230mg), sodium azide (309mg, 4.75mmoJ?) And beryllium beryllium (105mg, 1.96mmoJ2) in anhydrous DMF (1 0 m L) The solution was heated under argon at 70 eC for 16 hours. After cooling, the solids were removed by filtration on a sintered glass funnel and then distributed in ethyl acetate and brine. The organic layer was separated and dried over MgS04. Concentrated in vacuum, and the residue was quickly chromatographed on silica gel (10% hexane / ethyl acetate). Each paper size is applicable to China National Standards (CNS) A4 specifications &lt; 210X297 mm)-'(Please read the note on the back first. (Refill the items, this page)-equipment, 17 Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs-407-4266 6 3, A7 B7 V. Description of the invention (405) 154mg (57% * 2 steps) 205, It was a yellow viscous oil with sufficient purity to be used directly in the next reaction. Example 1 0 8 N—Acetyl azide 24 5: Acetyl chloride, 0.98 mm 2) was added to 0 ° C. amine 205 (154 mg, 0.61 mm 2 i 2) and pyridine (1.3 mL ) In CH2C ^ a (4.0 mL). OaC, 1.5 hours later, concentrated and distributed in ethyl acetate and brine. The organic layer was separated, washed sequentially with saturated sodium bicarbonate, brine, dried over Mg S 04 and concentrated in vacuo. The residue was subjected to flash chromatography on silica gel (ethyl acetate) to obtain 167 mg (; 93%) of a light yellow solid. Of 2 4 5 Please read the notes on the back of% before printing the example printed by the staff of the Central Bureau of Standards of the Ministry of Economic Affairs, Cooperative Cooperative Society of China. 1 0 9 Amino ester 200: Add triphenylphosphine (1.7 g, 6.48mmo) 2) to 245 points (1. 78g, 6. Olmmoj?) In a solution of THF (40mL) and water (1.5mL), and allowed to stir at room temperature for 42.5 hours. The volatiles were removed under vacuum, so that the crude solid was adsorbed on silica gel, and purified by flash chromatography on silica gel (100% ethyl acetate, then 100% methanol) to obtain 1.24g (77%) Light-colored solid 200 »Example 1 1 0 Amino acid 1 0 2: Aqueous KOH solution (3 7

L This paper size applies Chinese National Standard (CNS) Λ4 specification (210X2mm) Λ 2 6 6 6 3 Λ Α7 ____ Β7_ V. Description of the invention (406) 1. ON) Methyl ester 200 (368mg) added to 0 ° C , 1. 37mmoj?) In THF (4.0 mL), let it stir at 0 ° C for 10 minutes, and at room temperature for 1.5 hours, then

Amberlite IR-120 (H +) acid resin was acidified to pH 7.0-7.5. The resin was filtered off and washed with water and methanol. Concentrated in vacuo to give the amino acid as a white solid, which was purified by Cle reverse phase chromatography (extracted with water). Fractions containing the expected product were collected and freeze-dried to give 29Omg (83%) amino acid 1 0 2 » Example 1 11 Amine hydrochloride 250: amine 228 (15.6 mg, 0.05 mmoJ2) was treated with 0.1 IN HCj? And evaporated to dryness. The residue was dissolved in water and filtered through a short C18 reverse-phase silica gel column. Lyophilized hydrochloride 250 (12mg) as a solid:

H Printed by the Central Laboratories of the Ministry of Economy, Shellfish Consumer Cooperatives 4 4 &gt; TJ », δ), H NJ. Ο H d 1 H (o 2 1, 3 2 ot \) / 9 \ J, 5H 9 II Η 11 1 II J 2 J ί Ϊ tmtm H () 1 TH ， 4 3 D »Γ d» 5 d., (Sbds 3 d 2 SI R-(c, / VI / VI / l \ j M656957881 N830769506 H 4 m / IV IX 4 quasi-j bidder I country I use M; one piece of paper

Ns Standard Rule 7 29 426663, B7 Printed by the Consumers' Cooperative of Shiyang Standard Bureau of the Ministry of Economic Affairs 5. Invention Description (407) 1! 0 8 8 (t, 3 Η f J = 7 4) 1 1 I 0 8 4 (t 9 3 Η * J = 7 4) 〇1 1 I Please 1 [Announcement 1 1 2 Read 1 | Read 1 | __ — B 0 c guanidine 2 5 1; Η g C 9. Ξ (L 2 5 mg &gt; Back 1 I 1 1 0 4 6 mm 0 9.) Amine added to 0 ° C 2 2 8 (1 2 6 mg * Note 1 I 1 0 4 2 m τη 0 J2) &gt; N, N — __ — Dibutoxycarbonylthiourea item again! (1 2 7 mg 0 4 6 mm 0 ί) and triethylamine (this [Loading page 1 1 2 3 β L 0 8 8 mm 0 J2) D Μ F (4 m L) Soluble '»w ·· 1 1 Solution 0 Let the mixture stir at 0 ° C for 30 minutes» Stir at room temperature 1. 5 1 1 Small 0 Dilute with ethyl acetate and filter through celite 〇The solvent was distilled off, and the residue 1 1 was distributed in ethyl acetate. 0 acetate and water and the organic layer with a saturated Wenqing washed Ν a C dry after one custom drying (Μ g S 0 4) filtering the solvent was evaporated. This crude product was purified on silica gel (1 1 2/1 1/1 — hexadecane / ethyl acetate) to obtain a solid BtUt ff fv body 2 B 0 C guanidine 2 5 1 (1 5 5 m 8 6 9% ) 〇 ') Line 1 Η N MR (CDC 1 3) δ] \ 1 1 4 0 (S 1 Η) 1 1 1 8 6 6 (d 1 Η J = 7 * 9) 1 1 6 8 (S &gt; 1 Η) 1 1 6 2 2 (d) 1 Η J = 8 9) [I 4 4 3-4 3 4 (m 1 1 Η) 1 I 4 1 9 — 4 0 8 (m »1 Η) 1 4 0 3 (τη 1 1 Η) 3 7 6 (S 3 Η) • 3 3 5 (mj 1 Η) 1 1 This paper size is applicable to the Chinese National Standard (CMS) Λ4 spot (2! 0X 297 mm)- 410-426663 A7 B7 V. Description of the invention (4〇8) 2 2 7 9 (dd Η 4 7. 7 47 — 2 · 36 (rn * 9 2 (s, 3 Η)), 1 4 9 (2 s, 1 8)) 8 9 (m, 6 Η). Η) 50 0 Window example 1 1 3 Guanidine acid 252: Added to a solution of dione Boc guanidine 251 (150 mg, 0.88 mm 2) in THF (3 mL) 1 0 3 9 N 仄 〇11 solution (337 Ren B) and water (6 74

μ. L). This mixture was allowed to stir for 3 hours, then a 1.039N KOH solution (6 7 # L) was added and stirred for another 2 hours. Filter to remove a small amount of dark precipitate. The filtrate was cooled to 0 ° C, and acidified to pH 4_5-5.0 with I R-120 ion exchange resin. The resin was filtered off, and the filtrate was washed with methanol * and the filtrate was evaporated to dryness. The residue was dissolved in CH 2 C 2 (3 mL) and cooled to 0 ° C., and then treated with trifluoroacetic acid (3 mL). (: Stir for 10 minutes, and then stir at room temperature for 2.5 hours. The solvent is evaporated, and the printed matter of the Shellfish Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs is dissolved in water, and a C_ 1 8 reverse-phase silica gel column (3 X 1. 5 cm) chromatography (first with water and then with 5% acetonitrile / water). Combine the fractions containing the product, evaporate to dryness * After the residue is dissolved in water, freeze dry to obtain a color solid. Guanidinic acid 252 (97mg, 79%) »Example 1 1 4 6 0 Azido acid 2 60: Aqueous KOH solution (1. * Paper size applies Chinese National Standard (CNS) A4 specifications (2i〇 X 297 mm) ^ 11 426663 ^ ^ V. Description of the invention (409) mL, 1.039N) was added to a solution of methyl ester 227 (268mg, 0.83mm〇i2) in THF (7.0mL). At room temperature Stir for 19 hours, acidify with Amberlite IR-120 (H +) acidic resin to pH 4.0, filter out the resin, wash with water and ethanol, and concentrate in vacuo to obtain a light orange foamy crude azide acid 2 6 0 , Which was used in the next reaction without further purification. Example 1 1 5 'Azide ethyl ester 261: DCC (172mg, 0-83mm〇i2) was added to carboxylic acid 260 (previously at room temperature) Reactive The crude product should have a solution of 0.83mmoJ?), Ethanol (150 and a catalytic amount of DMAP in CH2C ^ 2 (6.mL printed by the Consumer Cooperatives of the Central Standard Bureau of the Ministry of Economic Affairs). A few minutes later, a precipitate formed, and After stirring for 1 hour, it was filtered and washed with CH2C. A light-colored solid was obtained after concentration in vacuum. Flash chromatography on silica gel (50% hexane / ethyl acetate) yielded 272 mg (96%, with a small amount of DCU purity). White solid 26 1. When DCC was replaced with diisopropylcarbodiimide, the yield of 26 1 was 93%, but if the DCC was used, the urea impurities were removed by chromatography and purification. Example 1 1 6 Amine Ethyl ester 262: Triphenylphosphine (342 mg, 1. 30 mm) was added to a solution of 261 in THF (17 mL) / water (1.6 mL). The reaction was then heated at 50 ° C.

A7 B7 4 2 6 6 6 3 λ V. Description of the invention (410) 10 hours. After cooling, it was concentrated in vacuo to give a pale white solid. This crude solid was purified by flash chromatography on silica gel (50% methanol / ethyl acetate) to give 242 mg (96%) of amine ethyl ester 262 as a light solid. It was dissolved in 3N HCj? And freeze-dried to obtain the corresponding water-soluble H C i? Salt. 1H NMR (D20-300MHz): δ 6. 8 4 (s &gt; 1 Η); 4. 36-4. 30 (br m, lH); 4. 24 (q &gt; 2H &gt; J = 7. 2 H z ); 4. 05 (dd, lH, J = 9. 0 &gt; 1 1. 7 H z); 3. 6 3-3. 5 0 (m &gt; 2 H); 2. 95 (dd, lH, J = 5. 7, 17. 1 H z); 2. 57 — 2. 4 5 (m &gt; 1 H); 1. 6 0-1. 3 9 (m-4 H); 1. 27 (t , 3H, J = 7. 2 H z); 0.8 9-0.8 8 (m &gt; 6 H). Example 1 1 7 Di-Bo c guanidyl ethyl ester 2 6 3: According to the steps of Kim and Qian, &quot; Tetrahedron Lett. 〃 34: 7677 (1993), HgCj? 2 (69mg, 0.25mm 〇5) — Added to amine 262 (72mg, 0.23 mm ο β), two one

Boc thiourea (66mg, 0.24mmoj?) And Et3N (108eL) in anhydrous DMF (600 / zL). Order-Paper size applies Chinese National Standard (CNS) Λ4 size (210X297 mm) ~ -413-(Please read the precautions on the back first and then fill in 1¾¼ pages)-Packing ·

、 Printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs of the 1T line 4.4.4.4. A7 B7 V. Description of the invention (411) The heterogeneous reaction mixture was stirred at 0 ° C for 1 hour, and then stirred at room temperature. 15 minutes, then diluted with EtOAc, filtered through a pad of diatomaceous earth * concentrated in vacuo, and the residue was subjected to flash chromatography on silica gel (20% hexane / ethyl acetate) to give 113 mg (89%) colorless foam状 之 2 6 3. 1Η N MR (CDC13 * 300MHz) δ 11.41 (s, lH); 8. 65 (d, lH, J = 8. 1 Η z); 6. 8 3 (s, 1 Η); 6. 22 (d, lH, J = 9-0 H z); 46 — 4 · 3 4 (m »1 H):

21 (q-2H &gt; J = 6. 9 H 2 2-4. 10 (in * 1 H); 0 4-4. 00 (m, lH); 36 (quintet, 1 H * 5. 7 H z ( Please read the notes on the back first and then fill in 1 page) • Packing. 2 2 Printed by the Consumer Cooperatives of the Central Bureau of Procurement, Ministry of Economic Affairs 7 8 (dd, 1 H, 4 6-2. 35 (m 9 4 (s, 3 H); H) 4 7. 7 H z 60 — 1. 4 0 (m · 4 H); 49 (s, 9H): 1. 5 0 (s · 9 H); 0

3 H 6.9Hz 3-0. 8 4 (m * 6 H) Example 1 1 «This paper size applies to China National Standard (CNS) A4 (2 丨 〇X 297 mm) -414-at 266 6 3 A7 B7 V. Description of the invention (412) Guanidine ethyl ester printed by the Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs 2 6 4 • 1 B 0 C Guanidine ethyl vinegar 2 6 3 (1 1 3 mg »0 • 2 0 mm 0 9.). C H 2 CJ? 2 (50 m L) solution was cooled to 0 ° C and then added pure trifluorofluoroacetic acid C 50 m L) 9 The reaction mixture was stirred at 0 ° c for 30 minutes * Stir at room temperature for 15 hours. 0 Concentrate in vacuo to obtain a light orange solid.> Purify with C 18 reversed phase chromatography (diluted with water) t Collect fractions containing the expected product.> Freeze-dried to give 6 3 m SC 6 6%) white CEf solid. Guanidyl ethyl ester 2 6 4 0 1 Η N MR (D 2 0-3 0 0 Μ Η ζ): δ 6 8 2 (S 9 1 Η) t 4 • 3 5 — 4 3 1 (m 9 1 Η) t 4 • 2 4 (Q 9 2 Η negative J = 7 1 Η ZO) I 3 9 5 — 3 8 7 (τη 9 1 Η) 3 8 5-3 7 6 (τη »1 Η) f 3 5 7 — 3 4 9 (m 1 Η) r 2 8 7 (dd &gt; 1 Η 9 J = 5 1 f 1 7-7 Η ζ) »2 4 6 — 2-3 4 (m 9 1 Η) r 2 • 2 0 (S 3 Η)» 1 * 6 0 — 1 • 3 8 (m 4 Η) r 1. 2 8 (t » 3 Η * J = 7 1 H ζ) 1 9 0-0.8 8 0 (6 Η Example 1 1 9 Enzyme inhibition: Using the above in vitro activity screening method, the following activities were measured (+: 10 — 100jtim, ++ : 1 — 10 / ZΠ1, this paper size is applicable to China National Standard (CNS) A4 (210x 297 mm) (Please read the precautions on the back before ^ 1 page)-Binding · Binding-415-Λ 2 6 6 6 3 λ V. Description of the invention (4 丨 3) + + + &lt; 1. Ο μm A7 B7 Printed compound IC by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs 5 0 1 0 2/1 0 3 (2: 1) + + + A. 1 7. a, 4, i + + 114 + + A * 1-a. 4. i + + 79 + 82/75 (1.2: 1) + 94 + + + A. 100.a. 11. i + + + A. 101.a. 1 1. i + + + A. 113. a.4. I + + + Applicable paper standards apply Chinese national standards ( CNS) A4 specification (210X297 mm) 416 _. Na ·-4 266 6 3, A7 _B7 V. Description of the invention i: 4H) mm 1 2__〇_ Compound A. 113. b. 4 as in Example 119, respectively. i and A.113. x. 4. i was cultured in enzyme analysis buffer and assayed for activity. Both activities were> 10 0 jum. Before testing as in Example 1, each compound was separately cultured in rat serum, and the activity of the two compounds was similar to that of compound A 113. a. 4. i. Caution Example 1 2 1 Intitutefor Antiviral Research, Utah Site University, under the supervision of Dr. Robert Sidwell, to conduct a study to compare Compound 203 (Example 69), GG167 and ribavirin in mice ( i. P. or P. route)). GG 1 6 7 and ribavirin are known compounds against influenza virus. Please read the notice items first

Order by the Central Standards Bureau of the Ministry of Economic Affairs

OH OH

xo2h HO (Ac) (H) N h, N NH NH nh2 GG167 mice: male 13-15g non-specific pathogen BALB / c mice were obtained from Simonsen Laboratories (Gilroy, CA) ° quarantine 2 to 4 hours before use, Placed in tfayne Lab B1 ox and faucet water environment table paper scale applicable to China National Standard (CNS) A4 specification (210X297 mm) -417-4 2 6 6 6 3 A7 B7 5. Description of the invention (415). Once infected, make drinking water contain 0.006% oxytetracycline (Pfizer., New York, NY) to control possible secondary bacterial infections. Viruses: The influenza virus A / NWS / 33 (H1N1) was obtained from K.W. Cochran, University of Michigan (Ann Arbor, MI). After Madin Darby dog kidney cells (MDCK cells) fusion monolayer infection, the cells were cultured in 37 ° C 5% C02, after 3 to 5 days, when the virus cytopathic efficacy reached 9 0-100%, cells were collected. And made into mother virus. Seal and store at -80 eC until needed. Compound: Compounds 203 and GG 1 6 7 were dissolved in sterile physiological saline for research. ,, Arterial oxygen saturation (S a 02) measurement: Measured with a Ohmeda Boix 3740 pulse oximeter (Ohmeda, Lonisville, 0H) using a ear probe, the probe is placed on the thigh of the animal, And choose slow speed measurement. Each animal was read after a 30 second stabilization period. The use of this instrument to determine the effect of influenza virus on the oxygen saturation of the veins is described by Si d we 11 et al., AntiDicrob.Agen1: s. Chemo1: her36: 473-476 (1 992). Experimental design of the oral study: 11 mice became a group of 1 who caused an intranasal infection of about 95% of the lethal dose of the virus and received various doses of the test compound. The doses of 203 and GG167 are approximately 50, 10, 2 and 0.5 mg / k g / day. Four hours of pre-infection of the virus followed i.P treatment (twice / day) for 5 days. On the 3rd to the 10th day, take 8 infected rats treated with each dose and 16 infected rats with saline. Please read the precautions on the back before this page)-binding-threading. This paper size applies Chinese National Standard (CNS) Λ4 specification (210X297 mm) -418-Printed by the Shellfish Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs 42666 ^ ^ A7 ____B7_ V. Description of the invention (416) Control group for treatment, analyze S a 〇2 The daily deaths of these animals were recorded for a total of 21 days. The remaining 3 animals in each group and 6 pairs were treated with saline. The control group was killed on the 6th day. Given a score (0 = normal, 4 = 1000% of lungs affected). Because no toxicity was found at a dose of 203 at 300 mg / kg / day, and literature reports show that GG 1 67 is also non-toxic, so No toxicity control group was used in the study. Experimental design of the intraperitoneal administration study: 11 mice became a group, which caused them to be infected intranasally with about 9 5% lethal dose of virus and received doses of 250, 50 or 10 mg / kg / Tianzhi 203 or GG167 or doses of 100, 32 or 10 mg / kg / Ribozole for the treatment of the virus. 4 hours of pre-infection of the virus followed by oral feeding (twice / day) for a total of 5 days. 8 animals in each group were left in place for 21 days * The number of deaths was recorded daily, on the 3rd day The Sa 02 value was measured until the 10th day, and the number of deaths of these animals was recorded daily for 21 days. The remaining 3 animals in each group and 6 control groups treated with saline were killed on the 6th day and the lungs were removed. Department, weighed, given a score of deep purple lungs (0 = normal, 4 = 100% of lungs affected) "15 infected rats were treated with saline only, left for 21 days and measured as above S a 02, take another 6 infected mice treated with saline, and kill them on day 6 for lung analysis. Three normal control groups were left for 21 days, and the S a 02 measurement was performed as above, and another 3 were taken. A normal animal was killed on day 6 and the lungs were weighed and scored. Experimental design of the low-dose oral study: 8 mice were grouped so that this paper size applies the Chinese National Standard (CNS) A4 (210X297) Mm) '-419-(Please read the precautions on the back, 顼 ΐ, front page) Binding · Order 4266 6 3 A7 B7 Economy Lmg / kg printed by the Central Bureau of Standards Consumer Cooperatives V. Description of the Invention (417) Its intranasal infection is about 90% of the lethal dose of the virus, and it receives various doses of test compounds. The doses of each compound are 10, 1 and 0.1 mg / kg / Day. 4 hours of pre-infection of the virus followed by ρ.〇. (Twice / day) treatment for a total of 5 days. On days 3-10, 8 infected mice and 16 treated mice were treated with each dose. The control group treated with saline was analyzed for its Sa 02 value, and the number of deaths of these animals was recorded every day for 21 days. Statistical evaluation: The increase in survival was evaluated by X 2 analysis and Yates correction. * The increase in mean survival time by t-test analysis was worse than Sa 02, lung weight and lung virus titer. Lung score differences were assessed using ranked sum analysis. In all cases, the difference between the study drug treatment and the saline-treated control group was i. P. The results of the dosing experiments are summarized in Table I and in Figures 1 and 2. In this model, the two compounds were significantly inhibited at high doses, and they also survived significantly at a dose of 10 mg / kg / day. The two compounds significantly inhibited Sa at 50 mg / kg / day. The decrease of 02 can be suppressed by GG167 at 10 mg / kg / day, or even 2 mg / kg / day. Lung fraction data showed the same trend, with G G 1 67 being effective at multiple doses. Some variability was seen in lung weight. The rats receiving the highest dose of GG 1 67 had a higher average weight than the saline-treated control group. The results of the P-0 dosing experiment are summarized in Table π, and the daily S a 02 values are shown in Figures 3-5. In this model, oral treatment of the three drugs has significantly inhibited influenza virus infection and prevented death, reduced lung scores and infection-related lung weight, and inhibited the decrease in Sa 02. ^ • Zhang scale is applicable to Chinese National Standard (CNS) A4 (210X 297 mm) ~ '~~ ---------- #-3 (Please read the precautions on the back before this page) ) Line 420 A7 B7 4 2 6 6 6 3 Λ V. Description of the invention (418) P. 〇. The results of the low-dose study are summarized in Table m and Figures 6-8. In this experiment, infection resulted in the death of 4 of the 16 saline-treated animals, and the average survival time in this group was 9.6 days. All three compounds have a certain degree of inhibitory effect on virus infection. 2 6 2 (ethyl prodrug) is the most effective at each dose, which can be verified by the number of survivors and the average survival time to prevent the decrease of S a 0 2. Table Π [shows the average Sa of all analysis times. Daily values for each compound are shown in Figures 6 to 8. Figure 6 shows the Sa02 data of the highest concentration of each compound; Figure 7 shows the values at the medium dose of each compound, and Figure 8 shows the S a 0 2 values at the low dose of each compound. Table Π and Figures 6 to 8 show that the three compounds all have an anti-influenza effect on experimentally induced influenza A (H1N1) virus infection when taken orally, and 2 6 2 is the most effective. It is uncertain whether the improved antiviral ability of 262 is accompanied by higher animal toxicity, but because its higher efficacy is presumed to be the result of higher oral bioavailability, high animal toxicity will not be possible. (Please read the note on the back and then fill in the "-" page) Order the "Itchy · Ministry of Economic Affairs Central Standards Bureau employee consumer cooperatives printed private paper standards applicable to Chinese national standards (CNS} A4 specifications {2! 〇 &gt; &lt; 297 mm) -421-4 266 6 3, A7 B7 Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs 5. Description of the invention (419) Table 1.20 3 and GG 1 6 7 i.pa The efficacy of A (Η 1 N 1) virus-infected mice is compared to infection. The average number of surviving doses of the therapeutic compound and the average mean lung parameter d. Live time Sa〇2 Cmg / kg) / Total b (days)% Fraction weight / day) (mg) 203 50 8/8 ** &gt; 21.0 ** 87.2 He Me q rj 173 * 10 3/8 * 10.8 84.7 2.5 217 2 0/7 12.6 84. 4 2.0 203 0. 5 0/8 11.1 85.2 * 2. 0 230 GG1 67 50 8/8 ** &gt; 21.0 ** 87.6 ** 0.7 * 230 1 0 7/8 ** 15.0 87. 5 ** 1.7 170 * 2 1/8 12.6 86.0 ** 1.3 213 0.5 0/8 12.3 84.5 2. 3 227 Brine-0/16 11.0 82.9 2. 0 22 0 This paper size applies to China National Standard (CNS) Λ4 size (2 丨 OX 297 mm) -422-4266 6 3 A7 B7 Ministry of Economy Printed by the Central Bureau of Standards, Consumer Cooperatives 5. Description of the invention (42) Table Π. The effect of 203, GG 16 7 and ribavirin on mouse influenza A (HI N1) virus infection after oral a The average survival time of the dose of the therapeutic compound is the average survival time Sa〇2e (mg / kg) / b (day)% / day of the total number) Mean lung parameter d Fraction weight (mg) 203 250 8/8 ** &gt; 21.0 * * 87. 9 * 0.8 ** 160 ** 50 8/8 ** &gt; 21.0 ** 87. 9 * 1.3 * 200 10 4/8 * 12.8 * 87.7 # 1. 3 * 240 GG167 250 8/8 ** &gt; 21.0 ** 88.6 * 0.3 ** 163 ** 50 8/8 ** &gt; 21.0 ** 88.0 * 1.5 * 187 * 10 5/7 * 10.5 85.2 1. 5 * 250 Ribazole 100 8/8 ** &gt; 21.0 ** 88.2 * 0.3 ** 140 ** 32 6.8 * 13. 0 88. 0 * 0.8 ** 163 ** 10 3/8 11.0 86.4 2.2 267 Brine-1/16 10.9 84. 5 2.4 203 paper Zhang scale is applicable to Chinese National Standards (CNS) Λ4 is present (210 X 297 mm) —423-Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs 4266 6 3 Λ at ____ Β7_ V. Description of the invention (421) Table m. 260,262 and Efficacy of GG167 on beta influenza A (HI Ν1) virus infection in mice after oral β Number of live (mg / kg / day) / total% of live live Average storage b (days) Average S a 0 2. (¾) 260 10 6/8 ** 75㈣ 13.5 ** 87. 6 * 1 3/5 38 11.8 86.8 0.1 0/8 0 10.0 84. 3 262 10 8/8 ** 100 *** &gt; 21. ( T * 88.1 ** 1 7/8 ** gg * * * 14.0 ** 87. 4 * 0. 1 2/8 25 11.I ** 85.7 GG1 6] F 10 5/8 * 63 * 12.3 ** 86.9 1 2/8 25 11.7 ** 85. 7 0. 1 0/8 0 9.8 83.5 Saline 0 2/16 13 9.6 83.8 Footnotes in Table k-IIa 4 hours after the virus is first produced 5 days b Animals dying on or before day c Mean value measured on days 3-110. d measured on day 6 compared to saline-treated control group. * P &lt; 0.05, ** p &lt; 0.01, *** P &lt; 〇. 001 This paper size is in accordance with Chinese national standard (CNS)> Λ4 specification (2 [〇x297 mm) -424-2. 6 6 6 3 A7 B7 Printed by the Central Bureau of Standards of the Ministry of Economic Affairs and printed by consumer cooperatives Description of the invention (422) Surprisingly, the above shows that in this model, oral or i.P. administration of GG 1 6 7 at a practical therapeutic dose is effective in reducing mortality in influenza-infected mice, although this And the conclusion of Ryan et al. (Antimicrob. Agents Chemother., 38 (1 0) i 22 70-22 75) [1994 ] Differently, Ryan states that "GG 1 6 7 has lower in vivo activity in mice administered intraperitoneally. Although it has good bioavailability, it is not easily penetrated into respiratory secretions because it is rapidly cleared from plasma. In addition, it is difficult to penetrate and stay in the internal cells ... Similarly, the low potency of oral administration may be due to, among other factors, the low oral bioavailability "(P. 2 2 7 4) These observations are consistent with Von Izstein et al. * W0 91/16320, WO 92/06691, and US Patent 5,360,817 (which covers or addresses GG167 studies). These patent documents do not teach or suggest the administration of GG167 in a manner other than intranasal » However, intranasal administration is neither convenient nor cheap. If there is a more feasible way to administer GG 16 7 and its related compounds (such as W Ο 91/16320, WO 92/06619 and US patent 5 3 6 0 8 1 7 (Shown) would be very beneficial. Therefore, a specific example of the present invention relates to a method for treating or preventing influenza virus infection in a host, which comprises administering a therapeutically effective amount of an anti-virus of formula (X) or (Y) to the host via a non-topical route to the respiratory system. Active compounds (please read the precautions on the back before filling the ^ page) • Binding and binding paper size: Chinese National Standard (CNS) A4 specification (mm) -Λ9 ^ stomach 425 426663 A7 B7

R2 V. Description of the Invention (423)

Where A is oxygen, carbon or sulfur in general formula (X), and A is nitrogen or carbon in formula (Y); R1 is COOH, P (0) (0 Η) 2 &gt; Ν 0 2 &gt; S00H , S03H, tetrazolyl, CH2CH0, CH0 or CH (C Η 0) 2 &gt;

R2MH, ORe, F, Cl, Br, CN, NHRe, SRe, or CH2X, where X is NHRe, halogen or OR0, and Re is hydrogen; Ci-C4 fluorenyl: linear or cyclic Ci— (: 6 alkyl Or its homologue substituted by halogen; allyl * · unsubstituted aryl or aryl substituted by: halogen, No2 'or C00H τ R3 and R3' are each the same or different from each other hydrogen, CN, NHR6, ^ '11 more) _, '-(Please read the notes on the back before filling this page) Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs

N 3, S R

N-0 R β 1 OR guanidino N-R6, NR6 OR6 -〇, —NHN-R6 r6 R6 R6 Ν Ν

-or- -Ν

Ν and / CH2- R4 are NHRe, SRe, 0Re, C00Re, Ν02 C (Re) 3, CH 2 C 0 0 R θ · CH2N02 or this paper size is applicable to China National Standard (CNS) A4 specification (210 X 297 mm ) -426-4 2 6 6 6 A7 B7 V. Description of the invention (424) C Η 2 NHR β, and R5 is CH2YRa, (: 11 ya 1160112 ya 6 or CHYReCHYReCH2YRe, where Y is 0, s, NH or Η And each γ portion in R5 is the same or different from each other, and a pharmaceutically acceptable salt or derivative thereof, except that in formula (X) (i) when R3 or R3 · is OR 6 or hydrogen, and A is oxygen Or sulfur, then the compound cannot have (a) R 2 is hydrogen and (b) R 4 is NH-fluorenyl, (ii) when Y is hydrogen, Re is a covalent bond, and in formula (y) (i) if R3 or R3 · is 0Re or hydrogen, and A is nitrogen, the compound cannot have (a) R2 is hydrogen and (b) R4 is NH-fluorenyl, (ii) when Y is hydrogen, Re is a covalent bond. Compounds of formula (X) and (Y) are in WO 91/16320, page 3, line 23 to page 7, line 1, WO 92 / Printed by the Consumer Cooperatives of the Central Standards Bureau, Ministry of Economic Affairs (first Read the notes on the back of the page.?; · Ν_This page) 0 66 1 9 and National Patent No. 5 3608 1 9 is described in more detail. In this document, (X) and (Y) are labeled I and ί a. For the purpose of this case, the path through the 'non-topical medication to the respiratory tract' is described. Do not exclude transbuccal or sublingual medication, and do not exclude 'occasional esophageal absorption when taken orally, via buccal or sublingual administration, as long as the buccal, oral, sublingual, or esophageal absorption is not intended for pulmonary 薬 or It is inhaled through the nasal cavity and the like. Generally, the compound is used as a shaped object, slurry or solution. This paper size is applicable to China National Standard (CNS) A4 specification (210X297 mm) -427-A7 A2G6S3 t ___B7 V. Description of the invention (425) In a typical embodiment of the present invention, the compound is GG 1 67, and the host is a non-rat animal (such as a mink or a human). The route of administration is oral, and the purpose of treatment and prevention is to reduce mortality. Feel free Use of a prodrug of a compound of formula (X) or (Y), although as shown above, it is not necessary to do so to achieve oral antiviral efficacy. As GG 1 6 7 and its related disclosed compounds, any of the compounds described herein Esters of compounds of the invention Other prodrugs can be used in combination with compounds of the formulae (X) and (Y) (eg, carboxylates or amidines). When GG 1 6 7 and its related compounds are administered orally or via a non-nasal route, The therapeutically effective dose can be determined by a general skilled physician according to the medicinal instructions of the compound of the invention. The most important parameters are the route of administration and the type of host. Generally, the dose from intravenous to subcutaneous to oral is increasing &gt; If it is used to larger animals, it can be applied according to the principle of pharmacological enlargement. The determination of the therapeutically active dose is a general technique in the technical field, but usually this dose will be approximately the same as that used by the compound of the present invention. 啻 Example 1 2 2 The reactions shown in Table 50 are printed by the Consumers ’Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs. The reaction is performed according to the reaction diagram 50. The progress of the reaction is indicated by "v". Unless otherwise indicated in Table 50. Steps AA, BB and AC are performed according to Examples 92, 93, and 94, respectively. Steps A and D are performed according to Examples 112 and 113 in combination. This paper size applies to Chinese National Standard (CNS) Λ4 specification (210X297 mm) 426663 A7 B7

V. Description of the invention (426) Reaction diagram τγν? 0 co2ch3

ROH N3400

AA

C02CH3

AB

402 C02CH3

(Please read the precautions on the back before filling out this page)

AD

404 Printed by the Consumers' Cooperatives of the Ministry of Economic Affairs of the People's Republic of China. NH · 0300300. This paper size applies to the Chinese National Standard (CNS) A4 specification (2I0X297 mm) -429-A7 B7 4 266 6 3 ^ 5. Description of the invention (427) -·· .. ^ 50 Printed by the Consumer Cooperatives of the Central Bureau of Accreditation of the Ministry of Economy $ 1 ROH ΑΑ ΑΒ AC AD / / a, b / c \ ^ 0Η / / / / a, dc, e / y / F3C ^ ▽ OH / y / / / / / / ^ 0Η dc .ΟΗ / / / f "OH // / / Three S OH / / / τ g The size of the paper is applicable to the Chinese National Standard (CNS) A4 specification (2〗 0X297 mm)- 430-426663 A7 B7 V. Description of the invention (428) Table 50 (continued) Consumption cooperation between employees of the Central Standards Bureau of the Ministry of Economic Affairs, ROH AA AB AC AD / / 0 Η / / / / OH y / / crH / / h / / r ^ 〇H / / 〆 ^^ OH / / by dy / OH / i, j / / 王 # 遣 .Write this page) This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) -431 — 426663 A7 B7 Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs 5. Description of the invention (429) Table 5 0 (Note) a) Before reduction of azide Ester hydrolysis b) azide reduction with Ph 3P at room temperature c) ester hydrolysis with KOH aqueous solution / Me 0H d) polymer carrying Ph 3P and azide reduction at room temperature e) isolation Become HCJ? Salt f) azide reduction with Me 0H / THF / H2 in Ph 3P / ¾) non-mirrored stereo: isomers, the main ones; marked _% _ / /, h) stacked in M e3P Nitrogen reduction i) Ring opening of aziridine at 5 5 ° C j) Mono-ionization of C-alkylation products

AcO Example 1 2 3 Trifluoroacetamide 340: 0 ° (: When adding pyridine (41 / zL 0. Slmmoj?) And trifluoroacetic anhydride (TFAA) (52 / zL, 0.37mmo again) to Amine 228 (100 mg-.34mmoj?) CH2Ci? 2 (private paper size applies Chinese National Standard (CNS) Ad specifications (210 X 297 mm) -------------- ---- 、 Order (Please read the notes on the back before filling in this page)

C02CH3

COoCH, -432-4 6 3 A7 B7 V. Description of the invention (430) (Please read the precautions on the back before filling out this page) 3. 5mL) solution, let it stir for 45 minutes and add additional TFAA ( 0.5 equivalent) After 5 minutes, it was evaporated to dryness under reduced pressure, and the residue was distributed in ethyl acetate and HCJZ. The organic layer was washed with saturated NaHC03 and saturated NaC5, dried (MgS04), filtered and evaporated to dryness. The residue was chromatographed on silica gel (2/1 —hexane / ethyl acetate) to give trifluoroacetamide 340 (105 mg '78%): 1 Η Ν Μ R (c DC 1 3: 1 δ 8 6 4 (d 1 1 HJ — 7 • 7), 6. 8 1 (s &gt; 1 H) &gt; 6. 4 8 (d 7 1 H »J = 8 · '2) 5 * / 4. 2 5 — 4 0 7 (m) 3 H) »3. 7 5 (sy 3 H) &gt; 3 3 7 (m, 1 H), 2. 7 6 (dd &gt; 1 HJ 4 5, 18 • 7) ， 2.5 4 cm * 1 H) &gt; 1 9 3 (s, 3 H), 1. 4 8 (m 9 4 H) 1 0 8 6 (m, 6 H) ° Example 1 2 4 Ministry of Economic Affairs Central Standards Bureau employee consumer cooperative printed N-methyltrifluoroacetamide 34 1: 0 ° C. Sodium hydride (10mg, 60% mineral oil dispersion, 0.25mm 05) was added to trifluoroacetamide 340 (90 mg, 0 23 mm) in DMF (2 mL). After 15 minutes at 0 ° C, methyl iodide (7 1 / z L &gt; 1.55 mm) was added, and it was stirred at 0 ° C for 2 hours and at room temperature for 1 hour. Acetic acid (2 8 v L) was added and the solution was evaporated to dryness. Let the residue be distributed in ethyl acetate and water * The organic layer is saturated-the paper size applies the Chinese National Standard (CNS) M specification (210X297g ¥ 7 ^ 266 6 3 ^ a? _____B7_ V. Description of the invention (431)

Na Cp was washed, dried (MgS04), filtered and evaporated to dryness. Chromatography of the residue on silica gel (1/1 -hexane / ethyl acetate) gave N-methyltrifluoroacetamidine 341 (81mg, 87%) as a colorless glass: 1 Η NMR Γ CDC 1 a) δ 6.80 (s, lH), 6.26 (d, lH, J = 99), 4. 6 7 (m · 1 H), 4. 3 2 (m &gt; 1 H), 4. 11 (m * 1 H), 3. 78 (s, 3H), 3. 3 2 (m, 1 H), '3.07 (brs, 3H), ".': / 2. 60 (m, 2H) &gt; 1.9 1 (s &gt; 3 H), 1.48 (m, 4H), 0.87 (m, 6H). Example 1 2 5 N —methylamine 342: 1.04N K Η (480 yL ' O. 50mm〇5) added to N-methyltrifluoroacetamide 341 (81rag-0.20mm〇1) in THF (printed by the Consumer Cooperatives of the Central Bureau of Standards of the Ministry of Economy (please read the precautions on the back before reading Fill in this page) 3mL) solution, and allow the mixture to stir at room temperature for 14 hours, acidify with IR-12 ion exchange resin to pH about 4. Filter out the resin, wash with THF, and evaporate the filtrate to dryness. The material was dissolved in 10% TFA / water (5mL) and evaporated to dryness, so that the residue was washed through a C-18 reverse-phase silica gel column (1.5x2.5cm) with water. The product fractions were collected and freeze-dried to give a white color. solid N-methylamine 3 4 2 (4 6 mg-5 6%): This paper size applies to China National Standard (CNS) A4 (210 X297 mm) '&quot; -434-4266 6 3 A7 B7 5 Description of the invention (432) Η NM R (D 2 0) 'δ 6. 8 0 (s ♦ 1 H), 4. 3 1 (brd, 1 H, J: = 8.8) 9 4. 0 9 (ddy 1 H * J = 8.9 • 1 1 6), 3.5 3 (m »2 H), 2. 9 8 cdd I 1 H, J = 5. 4, -1 6. 9), 2 7 3 (s &gt; 3 Η 2. 5 2-2. 41 2 0 7 (s * 3 Η m Η) ------------ (Please read the precautions on the back first Fill in this one hundred and six.1-1.39 (m, 4H) 0. 8 4 (m, 6 Η). f Printed by the Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs 1 1 6 啻 Example 1 2 fi Compound 346: 8 / l-MeOH / H2〇 (440mL in epoxide 345 (13.32g., 58.4mmoj?) , V / v) solution, sodium azide (19.0 g'292. Ommoj?) And ammonium chloride (2.69 g, 12 9. 3 mm ο i?) Were added, and the mixture was refluxed for 15 hours. After cooling, it was concentrated under reduced pressure and distributed in E t OA c and water. The organic tincture was sequentially washed with saturated bicarbonate 'brine. After drying (Mg S 04), it was concentrated in vacuo. Flash chromatography on silica gel (30% EtOAc / hexane) gave 11.81 g (75%) of viscous oil azide alcohol 346. NMR (300MHz, CDC13) 5 9 0-6. 8 6 (m-1 Η); This paper size applies to Chinese national standards (CNS &gt; A4 grid (210X297 mm) -435 — 4 6 6 6 A7 B7 Economy Printed by ZTE Ministry of Music and Shellfish Consumer Cooperatives and Invention Description (433) 4.80 (s-2-); 4.32 Cbt '1H, J = 4. 2Ηz); 4. 22 (q &gt; 2H * J = 7. 2 H z); 3 90 — 3 74 (overlapping π′2Η) t 3. 4 4 (s * 3 H); 2. 90 (d, lH'J = 6.9 Hz) 2. 94-2. 82 (m-lH); 2.35_2, 2l (m, lH); 1. 30 (t, 3H, J = 7. 2 Hz). / 12 7 Compound 3: 4.7: ethyl acetate 3 4 6 (4 2 Omg ’

1. 55mmoJ?) Of anhydrous THF (8 '0mL) solution was cooled to a temperature of 78 ° C, D 1 (5.1 M L, 1. OM toluene solution) was added dropwise with a syringe * let this bright yellow reaction mixture in Stir at 1.78 ° C for 1.25 hours' slowly add MeOH (1.2 mL) to slowly hydrolyze it. Removal of volatiles ’under reduced pressure allows the residue to be distributed in EtO Ac and cold dilute HCj ?. The organic layer was separated, and then extracted with gtOAc. The organic layers were combined, washed sequentially with saturated bicarbonate, brine, dried (Mg S 04), and concentrated in vacuo. Then the gum was cut (20% hexane / E t OA c) Up-link flash chromatography gave diol 347 (12727 house, 3 6%) as a colorless, viscous oil. 1 H NMR (300MHz, CDC13) δ 5 · 83 — 5. 82 (m, lH) »This paper is from the national standard of Xiaocaiguo I ··)-, Γ 426663 A7 B7 V. Description of the invention (434) 4. 7 8 (S * 2 H); 4. 2 1 (bt &gt; 1 H, J = 4.4 Hz) 4. 0 6 (bs 2 H); 3. 8 5-3. 6 5 (overlapping in, 2 H); 3. 4 3 (s, 3 Η); 3. 18 (d &gt; 1H * J = 8. 2. 51 (dd, lH, J = 5 2. 07 — 1. 9 0 (m &gt; 1 H 1.92 (bs, lH).

Hz): 5-17 7 Hz / The attached patent application scope is for the specific example of the present invention, and it should be understood that it includes insubstantial changes. Printed by the Consumer Standards Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs

This paper size applies to Chinese national standards (CNS> A4 size (210X297 mm) -437

Claims (1)

3 6 6 6 2 4 ^ wo S 8 8 Λ BCD V, patent application scope (IN ') I repair W: 1 &amp; charge No. 8 5 1 〇 7 4 8 7 Chinese Patent Application Amendment _October, 1989 Amend the formula (m') or (iv ') Compounds, (Please read the notes on the back before filling this page) Where Eι is —COORa ', where Ra is Η, Ci—Ce alkyl or phenyl_Ci—C4 alkyl, G! Is N3, 0H, -0R6a, or W—Ministry of Labor, Ministry of Economic Affairs The consumer cooperative prints T i 1 to 3 halogen atoms substituted C i — C 4 alkylcarbonyl groups or Ti and combines with Ui or Gi to form the group shown below: where R6a is p-toluenesulfonyl or methanesulfonyl, W2 -NHRb [Rb is Η, -CH = NH, or -CC = NR c) (NR dR e), where is H or a third butoxycarbonyl group; H3 is 1 ^ or Ci_C4 alkyl; or third butoxy Carbonyl]; is NHW 3, where W3 is Η, _S02—Ci—C4 alkyl, or any Chinese paper standard (CNS) A4 specification (210X B7): 4266 6 3 A8 ^ B8 CS D8 t. The scope of patent application-where RSb is H, Cx-C4 alkylcarbonyl, third butoxycarbonyl or trityl; U! Is {: 1-cs alkylthio, or an or5, of which 3 is! ^, C2-Ce alkenyl, Cs—Cs cycloalkyl, —C (= 0) — — Ce alkyl, -CH2NH2 or -CH2NH—C (0) 〇-third butyl.] | Or Ci-C12 Alkyl (optionally substituted with 1 or 2 0H, Η_CWCH2 Cl-C4 alkoxy, Ci-C4 alkylcarbonyl, formaldehyde, substituents). 2. The compound as claimed in item 1 of the patent application, which has the formula (III ')-3. The compound as claimed in item 1 of the patent application, wherein D 1 is -N H W 3. 4. For example, the compound in the first item of the scope of patent application * where butyl 1 and 1: 1 or 0: are combined to form a group of the formula This paper has been used in the standard Θ 0 standard (CNS) A4 specification (210 X 297 public) {Please read the intention on the back before filling this page) 2 266 6 3 Α8 88 C8 D8 6. Scope of patent application 5. For example, the compounds in the scope of patent application No. 1 are from the following groups: Among them: T: selected h3c Λ 'ομν ^ C 2 Η F ο Λ Ν-Η Λ C] ra Ο ο Human Ν-Η Λ C 3 FX Ν'Η Λ If the compound in the scope of the patent application item 1, R 83 is Η. If the compound in the scope of the patent application item 1, ^: ^ is -C Ο Ο Ο 8. If the compound in the scope of patent application No. 1 | where Ei is selected from the following groups: —COO_CH2— CH2-C3H5, OH O-CH, 0 ch3 (please read the general matters on the back before filling this page) -------- Order --- lilt discouraged Ministry of Economic Affairs &quot; Property Bureau employee consumer cooperatives India Double-ch3 ch3 CH, 0 OHr -CH, 0-9. The compound according to item 1 of the scope of patent application, wherein Ei is C 02Ra, and Ra is n-Ci-Cs alkyl group or terminal C C β alkyl group. The size of this paper is applicable to the National Solid Standard (CNS) Al specification (210 X 297 male flowers) 426663 A8 巳 8 C8 D8 Η 3) 2 C 〇) Η C Ο-, printed by the Consumer Goods Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs Patent scope 10. The compound as claimed in item 9 of the patent scope, wherein El is -C (0) 0 (CH 2) b CH ((CH2) cCH3) 21 b = 0 to 4'c = 0 to 4, b + c = l to 4s i 1. For example, the compound in the first scope of the patent application • wherein 诹 2 is amine or guanidino. 1 2. The compound according to item 1 of the scope of patent application, wherein 1: 1 is -〇-CH2CH (Ci-C4 alkyl) ^ CH20 (C! -C4 alkyl). 13. As for the compound I in the first item of the patent application, wherein Ui is (ch3ch2) 2cho-, (C Η 3 c Η 2) (C Η 3) c Η Ο-· (C Η 3) a C Η Ο-, (C Η 3) 2 C Η C Η 2 〇-, -C Η 3 (C Η 2) 40-, C Η 3 (C Η 2) 30-, CH3 (CH2) 20 —, (C Η a C Η 2) (C (C Η 3 C Η 2 c Η 2) (C Η 3 C Η 2) Η C 〇-, (C Η 3 c Η 2 C Η 2) (C Η 3 C Η 2 C Η 2) Η C 〇 一, cyclohexyl ο — or cyclopentyl -10 — = 1 4. The compound according to item 1 of the scope of patent application, wherein the compound is 0 to 2 OH, Ci — C4 alkoxy or formyl Substituted (: 4-C 8 fluorenyl a 1 5. For example, the compound in the scope of the patent application, wherein 〇1 is -NHR b ^ 1 6. For the compound 1 in the scope of the patent application, 1 of which 01 Paper Standards Used 0 National Standard (CNS) A &lt; 1 Specification (210 X 297 mm) (Sr first read the precautions on the back before filling this page). Loading -------- Order ---- ----- H 16. The scope of patent application is from the following groups: Η yNH2 丫 NH __ 1 nh2 42666 3, Aa B8 C3 D8 17. The compound according to item 1 of the scope of patent application, wherein W3M C:! — C 4 alkylcarbonyl. 1 8. If the compound in the scope of patent application for item 1, five of them: -C 0 0 R a -G 1 is v. (Please read the ^ intention of the arm surface before filling in this page) Install V h ^ n 2 TNH HN Consumer Cooperatives of Intellectual Property Bureau of Ministry of Economic Affairs, India, n3 C'N YN H'N y 2 H or ΐ HIVN H3 c 111 is 〇1 (Ci—C12 — hospital base) 1 —〇1 (C2-ce base). 19. If the compound in the scope of patent application No. 18 • U1 is selected from the following groups: (CH3CH2) 2CH0 —, This paper has been used in the standard 0 because of the family standard (CNS) A4 specification (210 X 297 cm) Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs &quot; 4 266 6 3 ^ A8 B8 C8 D8 t, patent application scope (CH 3 C Η 2) (CH a) CHO-- (C Η 3) 2 c Η Ο-, (C Η 3) 2 c HC Η 2 〇-, -C Η a CC Η 2) 401, C Η 3 (C Η 2) 3 〇-, CH3 (CH2) 20-(C Η 3 C Η 2 ) (C Η 3) 2 C Ο-, (C Η a C Η 2) (C Η a C Η 2) HCO —, CC Η 3 C Η 2 C Η 2) (c Η 3 C Η 2) Η C 〇-, (C Η 3 C Η 2 C Η 2) (c Η 3 C Η 2 C Η 2) Η C 〇 one, cyclohexyl -10-or cyclopentyl -10-. 2 0. The compound according to item 2 of the patent application has the following formula T1 i G &quot; i 〇 2 1. The compound according to item 20 of the patent application, wherein Gj-N (H) (R b). 2 2. The compound according to item 20 of the scope of patent application, wherein R5 is a branched alkyl group having 3, 4, 5, -6, 7, or 8 carbon atoms. 2 3. The compound according to item 20 of the scope of patent application, wherein R &amp; is 1 ^ or an alkyl group having 1, 2, 3, 4, 5, or 6 carbon atoms. 2 4. For the compounds in the scope of patent application No. 20, in which the paper size applies the Chinese National Standard (CNS) A4 specification (210 X 297) (please read the precautions on the back # 'Fill this page first) &quot; ^ Qiu --------- Order --------- 426663 A8 R8 C3 D8 VI. The scope of patent application G 1 is _ N Η 2; R &amp; is Η or has 1,2 , R Yuan Ji; R 5 is an alkyl group having 3, 4, 5, €. 2 5. If the compound of the 4th, 5th, or 6th carbon atom of the scope of the patent application is a branched item of 7 or 8 carbon atoms, it has the following formula co2h C02CH2CH3 2 6. If the compound of scope 25 of the patent application, it has the following formula ----------- ^ I pack ---.----- order --------- /-(please read the precautions of your mouth before filling in this page) Economic but intellectual property bureau staff consumer cooperatives &quot; 7H 2 7. If the compound of the scope of patent application for item 1 has a formula (2 7 8) or (2 7 9): This paper size applies the Chinese family standards ( CNS) A4 specification (210 X 297 male) 426663, A8 BS C8 Π8 6. Scope of patent application N3 Gan out (273) yr in-----RngCi-Ce alkyl or phenyl-C:-C4 alkyl: RS3 is Ci-C12 alkyl substituted with C:-C4 alkoxy. 28. If the compound of the scope of patent application No. 27, RS1 is a linear or branched alkyl β 2 with 1 to 6 carbon atoms. If the compound of the scope of patent application No. 28, R51 is Group, ethyl, n-propyl, isopropyl, n-butyl '' second butyl, isobutyl or third butyl ”30. For example, the compound in the scope of patent application No. 29, where RS1 is Ethyl. 31. The compound according to item 27 of the scope of patent application, wherein R53 is ch3—〇_ch2—. 3 2. If the compound in the scope of patent application No. 1 is a pharmaceutical composition β 3 3 for the preparation or treatment of influenza infection, a method of preparing a compound of the following formula, (please read the following first) (Please fill in this page again for attention) Printed by the Consumer Cooperative of the Intellectual Property Office of the Ministry of Economy R 0 η'ν I Η COa ^ si Where, as defined in the first paragraph of the patent application, R51 is C Ca alkyl or phenyl—CC 4 alkyl. This paper is applicable to Θ National Standard (CNS) A4 specification (210 χ 297 male; S) 1 ft- 3 6 6 6 2 4 S888 ABCD Patent Application Scope This method includes treating compound 2 8 FVN 〇Co2Rsi n3 281 with a compound of formula 50 Η where R 54 is an aziridine activating group. 34. A method for preparing a compound of formula 272 OR52 272 where: R5. It is a 1,2-diol protecting group; Chin 31 is O1-C3 alkyl or phenyl-Ci-(: 4 alkyl R 5 2 is a hydroxyl activating group; this method includes making crotonic acid ----- ------ ^ · --------- Order ----------% 1 {.: V '(Please read the precautions of the arm surface before filling this page) Economy Printed by the Consumer Cooperatives of the Ministry of Intellectual Property Bureau &quot; 6 0H 'h〇a,. ^ \ L * C02H After treatment with bisdialkoxyalkane or bisdialkoxycycloalkane and acid, a compound of the following formula is formed. This paper is applicable to the standard of China® National Standard (CNS) A4 (210 X 297); .426663, patent application scope A8 B8 C8 D8 R 0H SQ 0 '' 0 0 274 Compound 2 7 4 is then treated with a metal alcoholate and an alkanol: the formula forms OH 〇〇2 ^ S \ (Please read the precautions for spraying before filling out this page) The staff of the Intellectual Property Office of the Ministry of Economic Affairs and Consumer Goods Cooperation Du Yinzhan then treated the compound 2 7 5 with a sulfonic acid halide and an amine to form a compound of the following formula ： 0H /0//,,./vvi^C02R5t OR52 276 Then treat compound 2 7 6 with dehydrating agent, and then treat with acid and alkanol to complete a 3 5 — a medicine used to treat or prevent influenza infection Composition | Including the compound as claimed in the scope of the patent application "36. The compound as in the scope of the patent application for item 1 is bound to a labeled or immunogenic carrier. This paper scale is applicable to the Chinese National Standard (CNS) A4 specification (210 X 297 male) 4266 6 3 4 Λ 6 C8 D8 6. Application for patent scope 37.-In vitro detection may contain neuraminidase The method of neuraminidase in a sample 'includes treating a sample that may contain neuraminidase by a composition containing a compound such as the one in the scope of patent application bound to a label; The active effect of the label "38.-A pharmaceutical composition for inhibiting neuraminidase, including the compound in the scope of the first patent application. ---------— (Please read the notes on the back before filling out this page), 1T printed by the Ministry of Economic Affairs, Zhisongshi '4 bureaus, 8 workers' consumer cooperatives, M National Standards (CNS) A4 Speaking Case (public writing) 11