TW422711B - Multi-channel ultrasonic high-temperature tumor curing system - Google Patents

Abstract

This invention is about multi-channel ultrasonic high-temperature tumor curing system that includes several channel driving circuits, in which the output terminal of each channel driving circuit is connected to a corresponding ultrasonic energy converter of the multi-channel ultrasonic energy converter array in order to drive this ultrasonic energy converter to generate ultrasonic signal. The driving circuit of each channel includes a phase control circuit, an amplitude control circuit, a switch circuit, a logic control circuit and a power amplifier. The phase control circuit is designed as frequency dividing circuit with different frequencies so as to simultaneously drive ultrasonic energy converter having different frequency. The reference clock is sent to the clock input terminal of this phase control circuit. Each channel is designed as the counter that has the function of preset initial value such that the output terminal of each channel has the phase-shift output signal. For the counter of each channel, the synchronous trigger signal is obtained by loading the same signal into the enabling line that is connected to the signal input enabling terminal of each counter. The programmable electric erasing logic devices are used in the phase control circuit and individually designed as an n-bit counter with the ability of presetting the initial value such that the phase control circuit has the phase shift resolution of (360/2n) phase angle. Different phase shift resolution is designed at each channel and the driving signal output with different frequency can be exported at the same time so as to form the heating area having different frequency. Therefore, based on the shape and size of tumor, the amplitude, phase, and frequency of the output signal are determined.

Description

V. Description of the invention (1) 1. Field of the invention: The present invention relates to an ultrasonic high-temperature tumor treatment system, in particular to a multi-channel ultrasonic high-temperature tumor treatment system. The present invention uses programmable logic elements to plan different frequencies. In order to make the present invention applied to the treatment of high temperature swelling, the invention can simultaneously drive ultrasonic transducers of different frequencies to increase the type of heating energy distribution for tumor treatment, and for different depths, sizes and shapes. Tumors are treated with ultrasound at different frequencies to achieve the best results. 2. Background of the invention and problems to be solved Ultrasonic high temperature tumor treatment technology uses ultrasonic energy to form a heating temperature field in the tumor area, and destroys tumor cells by high temperature to achieve the effect of treatment. Therefore, how to make the ultrasonic energy to form a uniform and effective heating temperature field in the tumor area is an important topic of ultrasonic high-temperature tumor treatment technology. Existing ultrasound high-temperature tumor treatment systems generally have only a single channel, which emits a fixed-frequency ultrasonic wave. In cooperation with a fixed single-voltage chip ultrasonic transducer, ultrasonic energy is converted into acoustic energy, which is absorbed by soft tissue to generate thermal energy. However, such a known system can only form a fixed type of heating area in the tumor area, so it can only effectively treat tumors with a fixed depth and a fixed size, which is obviously not ideal in terms of actual treatment results. In fact, the size, depth, and shape of tumor growth are not the same, and the depth of each part of the same tumor will be different, so the ultrasonic energy required by each part will also change accordingly, so it needs to be able to cooperate The shape of the tumor is used to simultaneously emit different frequencies of amplitude and phase for each site.

Ｍ27ί I V. Explanation of the invention (2) The best therapeutic effect can be achieved only by treating the tumor with high temperature. Summary of the invention: Therefore, in view of the shortcomings of the prior art and the actual needs, the main purpose of the present invention is to propose a multi-channel ultrasound high-temperature tumor treatment system that can treat tumors of different depths, sizes, and shapes differently. Ultrasonic waves of frequency are treated to achieve the best therapeutic effect. Another object of the present invention is to provide an ultrasonic high-temperature tumor treatment system with a multi-channel array type ultrasonic transducer. When performing tumor treatment, the relative phase of the output signals between different channels can be changed to adjust the energy field Focus position for effective treatment of tumors of different locations and depths. In order to achieve the above-mentioned object, the system architecture of the preferred embodiment of the ultrasonic high-temperature tumor treatment system of the present invention mainly includes a reference clock signal generator for generating a reference clock signal, a plurality of driving modules, each The driving module has a micro processing unit and several channel driving circuits. The output end of each channel driving circuit is correspondingly connected to an ultrasonic transducer of a multi-channel ultrasonic transducer array to drive the ultrasonic transducer. The generator generates an ultrasonic signal. Each channel driving circuit includes a phase control circuit, an amplitude control circuit, a switching circuit, a control logic circuit, and a power amplifier. The phase control circuit is planned to have different frequencies. The frequency division circuit is used to drive ultrasonic transducers of different frequencies at the same time. The clock input of the phase control circuit is used to input the reference clock. Each channel is planned as a counter with a preset initial value function. The output will have a phase shifted output signal. The counter of each channel is determined by

4227 1 1 V. Description of the invention ¢ 3) The same signal loading enable line is connected to the signal input enable terminal of each counter as a synchronous trigger signal. The phase control circuit is programmed with a programmable electrical erasing logic element to be a η-bit counter with a preset initial value, so that it has a phase shift resolution of a phase angle of (360/2 η). The other objects and system architecture design of the present invention will be further explained by the following attached drawings, among which: (—) Brief description of the drawings: Figure 1 is a system architecture diagram of the present invention; 2 is a diagram 1 The circuit structure diagram of the driving module shown in Figure 3. Figure 3 shows the signal line connection between the first channel driving circuit and the micro-processing unit in the main control circuit in Figure 2. (II) Description of drawing number 1 Master control drive module 2 Slave drive module 3 Reference clock signal generator 4 Power supply circuit 5 Multi-channel ultrasonic transducer array 6 Computer device 1 0 Master control circuit 1 1 First channel Drive circuit 1 2 Second channel drive circuit 1 3 Second channel drive circuit 1 4 Fourth channel drive circuit 1 5 Fifth channel drive circuit

42271f V. Description of the invention (4) 16 Sixth channel drive circuit 17 Seventh channel drive circuit 18 Eighth channel drive circuit 61 RS-232 interface 110 Phase control circuit 111 Drive transistor 112 Amplitude control circuit 113 Control logic circuit 114 Switch The circuit 115 power amplifier is shown in FIG. 1 'It shows the system architecture of the multi-channel ultrasonic high-temperature tumor treatment system of the present invention. It includes a master driving module 1 and a slave driving module 2 (Slave Driving Module), a reference clock signal generator 3 (Reference Clock Signal Generator) '-a power supply circuit 4, and a multi-channel ultrasonic phased array 5 (Ultrasound Phased Array). The reference clock signal generator 3 may use a conventional synthetic signal generator (eg, Synthesized Function Generator, such as DS345, Standford Research System 'Sunnyvale, CA.). The power supply circuit 4 is used to provide the working power required by the system, such as its Can provide + 30V ~ 300V, + 12V, -12V, + 5V DC working voltage. The system can also be combined with a computer device 6 to perform command delivery or data, setting value setting. For example, it can be connected to the reference clock signal generator 3 through a GP1B interface, and also through a standard RS-232 interface. And master

Page 9 f V. Description of the invention (5) Drive module 1 is connected to the slave drive module 2 A $ — + money. The reference clock signal generator 3 can be used to generate a square turbidity with a fixed output amplitude > β of η _ & No. 4 'to supply the participants required by the master drive module 1 and the slave drive module 2 n £ 1 clock

Clock). The connection signals between the master control drive module 1 and a slave robotic chess group 2 include power supply (DC Power Lines), control signals (c0ntr〇1 Signa 1), and data bus (D ata B us). Reference Clock Signals. In the preferred embodiment of the present invention, 'the main control driving chess set 1 includes a main control circuit 10 and eight channel driving circuits 1 丨 ～ 8 * As shown in Figure 2, and each channel driving circuit 11 ～ 18 is The driving signal can be sent to one of the transducers of the ultrasonic transducer array 5 shown in FIG. 1 through the driving signal output terminals 0P1 to 0P8. Similarly, the slave driving chess set 2 also includes a main circuit board and eight driving circuits. The aforementioned main control circuit 10 mainly includes a micro processing unit and a data port. In an actual circuit making example, the main control circuit 10 can be arranged as a main board, and each channel driving circuit can be made into a driving card type. Several circuit card slots can be arranged on the main circuit board, and the circuit cards can be inserted. The system working mode of the present invention is divided into two working modes, one of which is called a master mode and the other is a slave mode. When the system is operating in the main control mode, the micro-processing unit of the main control circuit receives the instructions sent by the computer device 6 through the serial port to control the operation of each driving circuit. And in the slave mode,

Page 10 4227 1 1 V. Description of the invention (6) The processing unit enables the master control drive module 1 to control the work of the master control circuit of the slave drive module 2 through the port. FIG. 3 is a schematic diagram showing a signal line connection between one of the channel driving circuits (for example, the first channel driving circuit 11) and the micro-processing unit in the main control circuit 10 in FIG. It can be known from the circle type that each channel driving circuit 11 of this creation includes a phase control circuit 1 1 0 ′-a driving transistor 1 1 1, a control logic circuit 1 1 3, a switching circuit 1 1 4, and a Power amplifier 115. The signal connections between the micro processing unit in the main control circuit 10 and the channel driving circuit 11 include address lines A0 ~ A15, read control lines / RD, write control lines / WR, data lines D0 ~ D7, and signal load. Enter the enable line Load. The purpose of loading the signal into the enable line Load is to enable the signals of multiple channels to be synchronized. In addition, the microprocessor unit is also connected to the computer device 6 through a standard RS-232 interface 61 or other similar serial data port. The computer device 6 in the system transmits the phase value of each channel output to the phase control circuit 1 through the RS-232 interface 61. When the phase control circuit 1 1 0 receives the phase value of each channel, it will send a response value to The computer device 6 performs frequency division and phase shift operations on the reference clock of the square wave type sent by the reference clock signal generator 3. The signal after frequency division and phase shift then enters the amplitude control circuit 112. At this time, the computer device 6 will transmit the input amplitude value of each channel to the amplitude control circuit 1 1 2 via the RS-232 interface 61. The amplitude control circuit 1 12 After receiving the response value, it sends it to the computer device 6 and changes the signal amplitude of the input power amplifier of each channel. The channel signal then enters the power amplifier 115 to amplify the output power, and the drive signal output terminal OP1 of the channel outputs the drive signal. Multichannel ultrasound transduction

_4m " 丨 ______ 5. Description of the invention (7) The device array 5 emits ultrasonic energy. In the design of the present invention, the phase control circuit 110 is planned with a programmable logic device (PLD, Programmable Logic Device). Frequency-dividing circuits of different frequencies enable the present invention to be used in the treatment of high-temperature tumors. Simultaneously drive ultrasonic transducers of different frequencies to increase the type of heating energy distribution for tumor treatment, which is helpful for the parameters that can be used during the treatment. In a preferred embodiment of the present invention, a PEEL (Programmable Electrical Erasable Logic) element is used to individually plan it into a π-bit (1 S n S 8) counter with a preset initial value as a 2n The phase control circuit has a phase shift resolution function of (360 / 2n) phase angle. Furthermore, the clock input terminal (CLK IN) of the phase control circuit 110 inputs a reference clock Ref Clk of a frequency 2n times the resonance frequency of the ultrasonic transducer to be driven. The initial phase value of each channel is written into the digital input terminal of the phase control circuit 110 via the RS-232 interface 61 by a computer device, and the initial phase value of each channel has a different initial value, so that the output of each counter will Output signal with phase shift. The counter of each channel is loaded by the same signal into the enable line Load and connected to the Load pin of each counter as a synchronous trigger signal. Since the counters of each channel have different initial values, each channel will change its high and low levels at different times, so the output of the counter will have a phase shift phenomenon. The advantage of using the PEEL element in the present invention is that it can be easily programmed into different bit counters to divide the same reference signal to generate different frequency drive signals, so that different frequencies of

Page 12 _422T1 V__ V. Description of the invention (8) Sonic transducer. The square wave signal generated by the phase control circuit 1 10 at its output after frequency division and phase adjustment is sent to the gate G of the driving transistor 1 1 1 (for example, using a MOSFET). When the potential of the gate G is When the square wave is at a high potential, the drain D of the driving transistor 1 1 1 and the source S are turned on, so the output terminal (ie, the drain D) of the driving transistor 1 1 1 is grounded. Conversely, when the gate G When the potential is the low potential of the square wave, the drain D and the source S of the driving transistor 1 1 1 are open-circuited, so the potential of the output terminal (the drain D) of the driving transistor 1 1 1 is the amplitude control. The circuit 112 outputs a voltage value of the signal. With the above-mentioned circuit architecture, planning different phase shift resolutions on each channel * can simultaneously output driving signal outputs of different frequencies, and synthesize heating regions with different frequencies, which can be determined according to the shape and size of the tumor Output the amplitude, phase and frequency of the signal to achieve the best tumor treatment effect. The preferred embodiments of the present invention have been described above. Those skilled in the art can make other improvements based on the above description, but these changes still belong to the spirit of the invention and the scope of patents defined below. in.

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Claims (1)

-i ^ osil 1 1- VI. Patent application Fan Yuan 1 · A multi-channel ultrasonic high temperature tumor treatment system, including a reference clock signal generator for generating a reference clock signal, a plurality of drive modules, each A driving module has a micro processing unit and several channel driving circuits, and the output end of each channel driving circuit is correspondingly connected to an ultrasonic transducer of a multi-channel ultrasonic transducer array to drive the ultrasonic transducer. Each channel driving circuit includes: a phase control circuit, which is planned to be a frequency dividing circuit with different frequencies > to drive ultrasonic transducers of different frequencies at the same time. The clock input terminal is used to input the reference clock. Each channel is planned as a counter preset with an initial value function, so that the output terminal of each channel will have a phase-shifted output signal. The counter of each channel is carried by the same signal. The input enable line is connected to the signal input enable end of each counter as a synchronous trigger signal; an amplitude control circuit is used to control the system The amplitude of the output signal; a control logic circuit connected to the data line of the microprocessor unit and the read and write signals, and generate control signals to the amplitude control circuit and the phase control circuit; a power amplifier whose wheel output end is connected to An ultrasonic transducer; a switching circuit controlled by the control logic to supply the working voltage required by the power amplifier; wherein the phase control circuit generates a square wave signal after frequency division and phase adjustment at its output, Will be sent to the gate of a driving transistor to control the signal level at the output of the driving transistor, and the signal is sent to the power Page 14 42271H_ VI. In the patent-pending Fan® amplifier, it is used as the driving signal to make each ultrasonic transducer generate ultrasonic signals with different frequencies. By planning different phase shift resolutions on each channel, then It can output driving signals with different frequencies at the same time, and it can synthesize heating regions with different frequencies. The amplitude, phase, and frequency of the output signals can be determined according to the shape and size of the tumor. 2. The multi-channel ultrasonic high-temperature tumor treatment system described in item 1 of the scope of the patent application, wherein the phase control circuit is a programmable electrical erasing logic element and is individually planned into a preset initial value of n bits. The counter has a phase shift resolution of a phase angle of (36 0/2 η). 3. The multi-channel ultrasound hyperthermia tumor treatment system according to item 2 of the scope of patent application, wherein the value of η is 1 S π S 8. 4. The multi-channel ultrasonic high-temperature tumor treatment system according to item 1 of the scope of patent application, wherein the clock input terminal of the counter of each channel in the phase control circuit inputs an ultrasonic transducer to be driven. The reference frequency is 2η times the resonant frequency. 5. The multi-channel ultrasonic high-temperature tumor treatment system as described in item 4 of the scope of the patent application, wherein the phase initial value of the counter of each channel is written to the digital input terminal of the counter via a computer device via the RS-232 interface, and Each counter has a different initial value, so that the output of each counter will have a phase shifted output signal. 6. The multi-channel ultrasonic high-temperature tumor treatment system according to item 1 of the scope of the patent application, wherein the driving module includes a master driving module and a slave driving module, and the master driving module and the slave driving module The connection signals include power, control signals, data buses, and reference clock signals. Page 15