TW421595B - A pharmaceutical composition for use in prevention and treatment of a gastrointestinal disorder - Google Patents
A pharmaceutical composition for use in prevention and treatment of a gastrointestinal disorder Download PDFInfo
- Publication number
- TW421595B TW421595B TW085116052A TW85116052A TW421595B TW 421595 B TW421595 B TW 421595B TW 085116052 A TW085116052 A TW 085116052A TW 85116052 A TW85116052 A TW 85116052A TW 421595 B TW421595 B TW 421595B
- Authority
- TW
- Taiwan
- Prior art keywords
- bismuth
- pharmaceutical composition
- patent application
- gastrointestinal
- scope
- Prior art date
Links
- 208000018522 Gastrointestinal disease Diseases 0.000 title claims abstract description 18
- 238000011282 treatment Methods 0.000 title claims abstract description 11
- 208000010643 digestive system disease Diseases 0.000 title claims abstract description 8
- 208000018685 gastrointestinal system disease Diseases 0.000 title claims abstract description 8
- 230000002265 prevention Effects 0.000 title claims abstract description 7
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract 13
- 229910052797 bismuth Inorganic materials 0.000 claims abstract description 20
- JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 claims abstract description 20
- 230000001404 mediated effect Effects 0.000 claims abstract description 11
- 241001465754 Metazoa Species 0.000 claims abstract description 7
- 230000002496 gastric effect Effects 0.000 claims description 18
- KKMOSYLWYLMHAL-UHFFFAOYSA-N 2-bromo-6-nitroaniline Chemical compound NC1=C(Br)C=CC=C1[N+]([O-])=O KKMOSYLWYLMHAL-UHFFFAOYSA-N 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 10
- 230000002079 cooperative effect Effects 0.000 claims description 6
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims description 6
- 241001489145 Trichuris trichiura Species 0.000 claims description 5
- 241000498255 Enterobius vermicularis Species 0.000 claims description 4
- 241000237858 Gastropoda Species 0.000 claims description 4
- 241000244159 Taenia saginata Species 0.000 claims description 4
- ZQUAVILLCXTKTF-UHFFFAOYSA-H bismuth;tripotassium;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [K+].[K+].[K+].[Bi+3].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O ZQUAVILLCXTKTF-UHFFFAOYSA-H 0.000 claims description 4
- 241001126302 Fasciolopsis buski Species 0.000 claims description 3
- 241000238631 Hexapoda Species 0.000 claims description 3
- 241000243797 Trichostrongylus Species 0.000 claims description 3
- 229940104825 bismuth aluminate Drugs 0.000 claims description 3
- JAONZGLTYYUPCT-UHFFFAOYSA-K bismuth subgallate Chemical compound OC(=O)C1=CC(O)=C2O[Bi](O)OC2=C1 JAONZGLTYYUPCT-UHFFFAOYSA-K 0.000 claims description 3
- 229960000199 bismuth subgallate Drugs 0.000 claims description 3
- 201000010099 disease Diseases 0.000 claims description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 3
- PDSAKIXGSONUIX-UHFFFAOYSA-N hexaaluminum;dibismuth;oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[Al+3].[Al+3].[Al+3].[Al+3].[Al+3].[Al+3].[Bi+3].[Bi+3] PDSAKIXGSONUIX-UHFFFAOYSA-N 0.000 claims description 3
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims description 3
- 229960004889 salicylic acid Drugs 0.000 claims description 3
- 210000001035 gastrointestinal tract Anatomy 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims 3
- 210000000936 intestine Anatomy 0.000 claims 3
- 241000498253 Ancylostoma duodenale Species 0.000 claims 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims 2
- 229940036348 bismuth carbonate Drugs 0.000 claims 2
- GMZOPRQQINFLPQ-UHFFFAOYSA-H dibismuth;tricarbonate Chemical compound [Bi+3].[Bi+3].[O-]C([O-])=O.[O-]C([O-])=O.[O-]C([O-])=O GMZOPRQQINFLPQ-UHFFFAOYSA-H 0.000 claims 2
- 235000015170 shellfish Nutrition 0.000 claims 2
- 239000011975 tartaric acid Substances 0.000 claims 2
- 235000002906 tartaric acid Nutrition 0.000 claims 2
- SPRBJFWIUVWXBT-UHFFFAOYSA-K tripotassium 2-hydroxypropane-1,2,3-tricarboxylate 2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound [K+].[K+].[K+].OC(=O)CC(O)(C(O)=O)CC(O)=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O SPRBJFWIUVWXBT-UHFFFAOYSA-K 0.000 claims 2
- WWYNJERNGUHSAO-XUDSTZEESA-N (+)-Norgestrel Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 WWYNJERNGUHSAO-XUDSTZEESA-N 0.000 claims 1
- 241000282412 Homo Species 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 125000003003 spiro group Chemical group 0.000 claims 1
- 230000000968 intestinal effect Effects 0.000 abstract description 8
- 244000000013 helminth Species 0.000 abstract 1
- 238000000034 method Methods 0.000 description 12
- 238000012360 testing method Methods 0.000 description 9
- 241001465677 Ancylostomatoidea Species 0.000 description 6
- 241000244206 Nematoda Species 0.000 description 6
- 150000001621 bismuth Chemical class 0.000 description 6
- 208000015181 infectious disease Diseases 0.000 description 6
- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical compound OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 description 4
- 208000014837 parasitic helminthiasis infectious disease Diseases 0.000 description 4
- 206010010774 Constipation Diseases 0.000 description 3
- ZREIPSZUJIFJNP-UHFFFAOYSA-K bismuth subsalicylate Chemical compound C1=CC=C2O[Bi](O)OC(=O)C2=C1 ZREIPSZUJIFJNP-UHFFFAOYSA-K 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 230000002183 duodenal effect Effects 0.000 description 3
- 235000013601 eggs Nutrition 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 208000004998 Abdominal Pain Diseases 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- 241000244177 Strongyloides stercoralis Species 0.000 description 2
- 241000869417 Trematodes Species 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- SULICOHAQXOMED-YDXPQRMKSA-H dibismuth;(2r,3r)-2,3-dihydroxybutanedioate Chemical compound [Bi+3].[Bi+3].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O.[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O.[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O SULICOHAQXOMED-YDXPQRMKSA-H 0.000 description 2
- 206010014881 enterobiasis Diseases 0.000 description 2
- 230000002550 fecal effect Effects 0.000 description 2
- 229940074391 gallic acid Drugs 0.000 description 2
- 235000004515 gallic acid Nutrition 0.000 description 2
- 230000007803 itching Effects 0.000 description 2
- 210000003097 mucus Anatomy 0.000 description 2
- 235000012149 noodles Nutrition 0.000 description 2
- 230000003071 parasitic effect Effects 0.000 description 2
- YXXXFTZMJKUYSM-UHFFFAOYSA-H 5-hydroxy-2,8,9-trioxa-1-bismabicyclo[3.3.2]decane-3,7,10-trione Chemical compound [Bi+3].[Bi+3].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O YXXXFTZMJKUYSM-UHFFFAOYSA-H 0.000 description 1
- 206010000060 Abdominal distension Diseases 0.000 description 1
- 206010000097 Abdominal tenderness Diseases 0.000 description 1
- 201000002045 Ancylostomiasis Diseases 0.000 description 1
- 208000033211 Ankylostomiasis Diseases 0.000 description 1
- 235000016425 Arthrospira platensis Nutrition 0.000 description 1
- 240000002900 Arthrospira platensis Species 0.000 description 1
- 241000244186 Ascaris Species 0.000 description 1
- 241000244185 Ascaris lumbricoides Species 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- HWSISDHAHRVNMT-UHFFFAOYSA-N Bismuth subnitrate Chemical compound O[NH+]([O-])O[Bi](O[N+]([O-])=O)O[N+]([O-])=O HWSISDHAHRVNMT-UHFFFAOYSA-N 0.000 description 1
- 239000004135 Bone phosphate Substances 0.000 description 1
- 241000253350 Capillaria Species 0.000 description 1
- 208000026368 Cestode infections Diseases 0.000 description 1
- 208000003322 Coinfection Diseases 0.000 description 1
- 208000002881 Colic Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 241000866683 Diphyllobothrium latum Species 0.000 description 1
- 206010013082 Discomfort Diseases 0.000 description 1
- 208000005577 Gastroenteritis Diseases 0.000 description 1
- 206010017964 Gastrointestinal infection Diseases 0.000 description 1
- 206010053759 Growth retardation Diseases 0.000 description 1
- 208000006968 Helminthiasis Diseases 0.000 description 1
- 241000742052 Heterophyes heterophyes Species 0.000 description 1
- 206010020376 Hookworm infection Diseases 0.000 description 1
- 241001464384 Hymenolepis nana Species 0.000 description 1
- 206010061598 Immunodeficiency Diseases 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 208000032420 Latent Infection Diseases 0.000 description 1
- 229910002651 NO3 Inorganic materials 0.000 description 1
- 241000970873 Nanophyetus salmincola Species 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 241000498270 Necator americanus Species 0.000 description 1
- 208000000291 Nematode infections Diseases 0.000 description 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- 206010033546 Pallor Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 241000244157 Taenia solium Species 0.000 description 1
- 241000242541 Trematoda Species 0.000 description 1
- 241000243777 Trichinella spiralis Species 0.000 description 1
- 241000486415 Trichiura Species 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 244000273928 Zingiber officinale Species 0.000 description 1
- 235000006886 Zingiber officinale Nutrition 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 230000002609 anti-worm Effects 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 229960001482 bismuth subnitrate Drugs 0.000 description 1
- 229960000782 bismuth subsalicylate Drugs 0.000 description 1
- REKWPXFKNZERAA-UHFFFAOYSA-K bismuth;2-carboxyphenolate Chemical compound [Bi+3].OC1=CC=CC=C1C([O-])=O.OC1=CC=CC=C1C([O-])=O.OC1=CC=CC=C1C([O-])=O REKWPXFKNZERAA-UHFFFAOYSA-K 0.000 description 1
- 208000024330 bloating Diseases 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 208000003796 chancre Diseases 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 208000037771 disease arising from reactivation of latent virus Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 210000001198 duodenum Anatomy 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 235000008397 ginger Nutrition 0.000 description 1
- 231100000001 growth retardation Toxicity 0.000 description 1
- 230000005802 health problem Effects 0.000 description 1
- 208000028774 intestinal disease Diseases 0.000 description 1
- 208000003243 intestinal obstruction Diseases 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 230000024241 parasitism Effects 0.000 description 1
- 229940101070 pepto-bismol Drugs 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 229940082787 spirulina Drugs 0.000 description 1
- 238000002563 stool test Methods 0.000 description 1
- 208000006379 syphilis Diseases 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 229940096911 trichinella spiralis Drugs 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
- 208000016261 weight loss Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/245—Bismuth; Compounds thereof
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56885395A | 1995-12-07 | 1995-12-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW421595B true TW421595B (en) | 2001-02-11 |
Family
ID=24273009
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW085116052A TW421595B (en) | 1995-12-07 | 1996-12-26 | A pharmaceutical composition for use in prevention and treatment of a gastrointestinal disorder |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5932564A (https=) |
| EP (1) | EP0865285B1 (https=) |
| AT (1) | ATE211914T1 (https=) |
| BR (1) | BR9611913A (https=) |
| CA (1) | CA2239422C (https=) |
| CO (1) | CO4761071A1 (https=) |
| DE (1) | DE69618617T2 (https=) |
| IL (1) | IL124742A0 (https=) |
| NO (1) | NO982633L (https=) |
| PE (1) | PE37198A1 (https=) |
| TR (1) | TR199801043T2 (https=) |
| TW (1) | TW421595B (https=) |
| WO (1) | WO1997020566A1 (https=) |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR962163A (https=) * | 1950-06-02 | |||
| US4049817A (en) * | 1972-08-14 | 1977-09-20 | Sandoz Ltd. | Synergistic compositions |
| US4514421A (en) * | 1979-08-30 | 1985-04-30 | Herschler R J | Dietary and pharmaceutical uses of methylsulfonylmethane and compositions comprising it |
| US5256684A (en) * | 1985-06-13 | 1993-10-26 | The Procter & Gamble Company | Methods and compositions for the treatment of gastrointestinal disorders |
| ATE79261T1 (de) * | 1985-06-13 | 1992-08-15 | Barry James M D Marshall | Verfahren zur behandlung von magen-darmstoerungen. |
| JPS63174926A (ja) * | 1987-01-09 | 1988-07-19 | Nitto Kasei Kk | 家禽用抗コクシジウム剤 |
| US5221664A (en) * | 1990-04-23 | 1993-06-22 | Magainin Pharmaaceuticals Inc. | Composition and treatment with biologically active peptides and toxic cations |
| DK0540613T3 (da) * | 1990-07-20 | 1996-04-01 | Tillotts Pharma Ag | Produkter og fremgangsmåder til behandling af fordøjelseskanalen |
| US5621142A (en) * | 1994-02-22 | 1997-04-15 | Asahi Kasei Kogyo Kabushiki Kaisha | Aminoalkylcyclopropane derivatives |
-
1996
- 1996-11-22 IL IL12474296A patent/IL124742A0/xx unknown
- 1996-11-22 TR TR1998/01043T patent/TR199801043T2/xx unknown
- 1996-11-22 CA CA002239422A patent/CA2239422C/en not_active Expired - Fee Related
- 1996-11-22 DE DE69618617T patent/DE69618617T2/de not_active Expired - Fee Related
- 1996-11-22 BR BR9611913A patent/BR9611913A/pt not_active Application Discontinuation
- 1996-11-22 WO PCT/US1996/018653 patent/WO1997020566A1/en not_active Ceased
- 1996-11-22 EP EP96940569A patent/EP0865285B1/en not_active Expired - Lifetime
- 1996-11-22 AT AT96940569T patent/ATE211914T1/de not_active IP Right Cessation
- 1996-12-04 CO CO96063578A patent/CO4761071A1/es unknown
- 1996-12-09 PE PE1996000885A patent/PE37198A1/es not_active Application Discontinuation
- 1996-12-26 TW TW085116052A patent/TW421595B/zh not_active IP Right Cessation
-
1997
- 1997-01-08 US US08/780,526 patent/US5932564A/en not_active Expired - Fee Related
-
1998
- 1998-06-08 NO NO982633A patent/NO982633L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0865285A1 (en) | 1998-09-23 |
| DE69618617D1 (de) | 2002-02-21 |
| WO1997020566A1 (en) | 1997-06-12 |
| CA2239422A1 (en) | 1997-06-12 |
| CA2239422C (en) | 2003-03-11 |
| PE37198A1 (es) | 1998-08-27 |
| IL124742A0 (en) | 1999-01-26 |
| MX9804579A (es) | 1998-10-31 |
| NO982633L (https=) | 1998-08-04 |
| CO4761071A1 (es) | 1999-04-27 |
| ATE211914T1 (de) | 2002-02-15 |
| TR199801043T2 (xx) | 1998-09-21 |
| EP0865285B1 (en) | 2002-01-16 |
| NO982633D0 (https=) | 1998-06-08 |
| DE69618617T2 (de) | 2002-09-19 |
| US5932564A (en) | 1999-08-03 |
| BR9611913A (pt) | 1999-03-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GD4A | Issue of patent certificate for granted invention patent | ||
| MM4A | Annulment or lapse of patent due to non-payment of fees |