經濟部十夾棣準局負工消费合作社印策 409933 3404twf-d〇c/002 C7 - ____D7__；_ 五、創作説明（丨） 創作領域_ 本創作是有關於一種質譜儀裝置，且特別是有關於一 種之定動量飛行時間式質譜儀。 貪丨作背量 質譜儀是相當重要的理化分析儀器，可以精確測定原 子或分子之質量。其基本原理是在真空中將樣品轉換成氣 相離子，並施加能量使其快速運動，然後進入質量分析器， 可依其質量與電荷的比(質荷比，m/e)而分離解析之以得k 質譜。傳統常見的質譜儀依其質量分析器之不同，約可分 爲：⑴磁場式（magnetic type)’（2)四極式（quadrupole type)， 及(3)飛行時間式(Time-Of-Flight，TOF)等三種。其中磁場 式及四極式質譜儀是利用掃描磁場或電場的方式來得到質 譜，因爲在某一磁場或電場下，僅有其相對應質量（質荷 比）的離子方能通過其質量分析器而被偵檢器所量測，署 if_到整質譜就必須果花二或電場做女節圍 的掃描：然画組分逝及jsj舌， y用磁場式或四極式質譜儀就無法得到全部的暫譜n。 相反的，飛行時間式質譜儀的特點就是一次即可得到全部 的質譜資料，現略述傳統飛行時間式質譜儀原理： 舊統_行時間式質譜儀如圖一所示，包括定動能離子 源裝置（或稱爲離子產生及加速裝置）11、離子漂移裝置（或 稱爲離子漂移管）12及離子偵檢(放大)器13等三部份。』斤 依遽里屋通量豈室離子源裝置11虫利里電屋加Jg離 子使各離子皆具有相同的動能(¾ = eV)_，質_量不同則速度 3 本紙張尺度逋用中國國家揉準（CNS ) A4規格（210X297公釐> --- (請先閲讀背面之注意事項再填寫本頁) 訂 經濟部中央揉準局*:工消费合作社印«. 3404twf.doc/002 409933 c? _D7_ 五、創作説明（>) 。如果控制各離子同時開始飛行，使通趟―定胃度 漂移區之離子漂移裝置12,則不同質量的離子到達離子= 檢器13的時間也會不同。設離子質量爲m，所帶讀荷爲+e : 同時受到V伏特電壓之加速，由於一般之設計其加速區皆 很短，故離子J1過漂移區距離L所須之時間爲： ti = W^ 即麗王蓝方根成正比故由_離子偵 …賴 13 所· 創作槪述 由上述卫譜·儀^其離篆源^產生 的各種離子均被電場，固此離子飛 行的時間與其質暈的卒方根成正±^。但是，源中 含有許多不同質暈的離壬避，則在大質量離无廣的時間分 離能力會較小質量者爲羞_;也就是靜，在相同的質量差之 .X，tf、質量離子間之飛行時間差較#，而大質鸷離子閒之 飛赶跋凰差斯較小。 如果能有某種方式可使各離子均具有相同的動量而非 動能時，就可以得到離子之飛行時間子之質量成正 .1;換句話說，即不論雛子質量之大小如何，墓mmi瓦離 、ΐ質量間之時間分離能一上素。眉 分析上就有許多好處_，， 其在輕暂量曉夕譜線分得很開很容易鑑別，而^重質量處 則擠在一起難以判別。由上所述，使用此種特殊之定動量 離子源裝置以飛行時間方式來獲得質譜者，稱之爲定動量 4 本紙張尺度逋用中囷固家揉準（CNS ) A4規格（210X297公釐） (請先閱讀背面之注意事項再填寫本頁) yt 订_ 3404twf.doc/002 409933The Ministry of Economic Affairs of the Ten-Faced Prospective Bureau, Consumer Policy Cooperative, India 409933 3404twf-d〇c / 002 C7-__D7__; _ V. Creation Instructions (丨) Creation Field _ This creation is about a mass spectrometer device, and in particular A constant-time-of-flight mass spectrometer. Mass spectrometry is a very important physical and chemical analysis instrument that can accurately determine the mass of atoms or molecules. The basic principle is to convert the sample into gas phase ions in a vacuum, apply energy to make it move quickly, and then enter the mass analyzer, which can be separated and analyzed according to its mass to charge ratio (mass-to-charge ratio, m / e). To get k mass spectrum. Traditional mass spectrometers can be roughly divided into: magnetic field type (2) quadrupole type, and (3) time-of-flight, depending on the mass analyzer. TOF) and so on. Among them, magnetic field and quadrupole mass spectrometers obtain mass spectra by scanning magnetic or electric fields, because under a certain magnetic field or electric field, only ions with corresponding mass (mass-to-charge ratio) can pass through their mass analyzer. Measured by the detector, if the full mass spectrum must be scanned by the flower or the electric field: if the component disappears and the jsj tongue, y can not be obtained with a magnetic field or quadrupole mass spectrometer Temporary spectrum n. In contrast, the characteristic of a time-of-flight mass spectrometer is that all mass spectrometry data can be obtained at one time. The principle of a traditional time-of-flight mass spectrometer is briefly described below: The old_time-of-flight mass spectrometer is shown in Figure 1, including a constant kinetic energy ion source. The device (or ion generating and accelerating device) 11, ion drift device (or ion drift tube) 12 and ion detection (amplifier) 13 are three parts. 『Jin Yili House Flux Chamber Ion Source Device 11 Zonglili Electric House plus Jg ions make each ion have the same kinetic energy (¾ = eV) _, speed is different for different masses and 3 Standard (CNS) A4 (210X297 mm > --- (Please read the precautions on the back before filling this page) Order the Central Standards Bureau of the Ministry of Economic Affairs *: Printed by the Industrial and Consumer Cooperatives «. 3404twf.doc / 002 409933 c? _D7_ V. Creation instructions (>). If the ions are controlled to start flying at the same time, so that the ion-drift device 12 of the fixed-dose-drift zone is used, the time when ions of different masses reach the ions = detector 13 will also Different. Set the ion mass to m and the read load to + e: at the same time it is accelerated by V volts. Because the acceleration region is generally designed to be very short, the time required for the ion J1 to drift through the drift region L is: ti = W ^ That is, Li Wang Lan Fang Gen is directly proportional to _ ion detection ... Lai 13 Institute · Creation Description All the ions produced by the above-mentioned guardian spectrum · instrument ^ its away from the source ^ are all subjected to the electric field, the time of flight of this ion and its quality The square root of halo is positive ± ^. However, the source contains many different quality halo. From Liren avoid, the time separation ability will be ashamed when the mass is large and the time is not wide; that is, static, the difference in flight time between the same mass difference. X, tf, mass ion is greater than #, and larger If the mass ion is free, the chasing phoenix is small. If there can be a way to make each ion have the same momentum instead of kinetic energy, then the mass of the ion time of flight can be obtained. 1; in other words In other words, no matter what the mass of the chicks is, the time separation between the tomb mmi and the mass of the tomb can be as high as possible. There are many advantages in eyebrow analysis. It is easy to identify, but it is difficult to distinguish the heavy masses. From the above, those who use this special constant momentum ion source device to obtain mass spectrum in time-of-flight mode are called constant momentum. CNS Gujia Standard (CNS) A4 (210X297mm) (Please read the precautions on the back before filling out this page) yt Order_ 3404twf.doc / 002 409933
Cl D7 Μ濟部中央標準局貞工消費合作社印製 五、創作説明（>) 飛行時間式質譜儀。 r 因此本創作的主要目的就是在提供一種定動量飛行時 \ 間式質譜儀，如此離子之飛行時間與離子之質量成正比， 因此可得均勻解析的淸晰質譜。 根據本創作之主要目的，提出一種定動量飛行時間式 質譜儀，包括：一定動量離子源裝置、一離子漂移裝潭、 /,以及一離子值I器。其中，定動量離子源裝置，用以產生 具有相同動量之離子；灕子漂移裝置mm#-定勸 1 -裝置所產生之*子温移骼徑；以及，離子偵檢器用以偵 測記錄定動量離子源裝置所產生之離玉通過離子漂移裝置 所需之時間。 ' 爲讓本創作之上述和其他目的、特徵、和優點能更明 顯易懂，下文特舉一較佳實施例，並配合所附圖式，作詳 '細說明如下： 圖式之簡單說明： ._ 名- 個一：傳統飛行時間式質譜儀； 圖二：定動量飛行時間式質譜儀； ’ 圖三：等間隔排列金屬圓孔之均勻等電場區； 圖四.：管內均勻電阻膜所形成之均勻等電場區；以及 •圖五：高解析之定動量飛行時間式質譜儀。 圖式之標記說明： I Π, 21，51 :定動能離子源裝置 1 I 12, 22:離子漂移裝置 13, 23, 53 :離子偵檢器 5 {請先閱讀背面之注意事項再填窝本頁) -訂 本紙張尺度適用中國國家標準（CNS ) Α4規格（210X297公釐） 34〇4twf.doc/〇〇2 409933 C7 D7 經濟部中央標牟局員工消費合作社印製 五、創作説明（¢) 31 :圓孔金屬薄板 32 :圚孔通道 41 :絕緣之圓形或方形管 42:電阻膜 43:金屬薄片或金屬細網 v 52 :動量過濾器 較佳實施例 圖二所示爲依照本創作一較佳實施例之一種定動量乘 行時間式質譜儀結構示意圖，此定動量飛行時間式質譜儀 包括一定動量離子源装置.21、一離子漂移裝置（一般爲無 電場漂移裝置)22與一離子偵檢器23。定:動量離子湎裝唐 (21包括角以產生離子之一離子產生器（未繪示h以及用以 加UE麗·子具有相同麗一邏子加速裝置（未繪 不）。定動量離子源裝置2丨可提供定動量的離子源.，特點 > a此询勻等 電場區之長度足以容許離子在被加速里間皆在此均句等 場區域內。所謂均勻等電場區是針對空間位置而_言_，t的 意_思晕指在任何一瞬間在此均勻.姜位置之重 場強摩皆相等向X方向)，繆Μ對時間座標而言，各點 位置之_強度可以是時變的。如果施加一脈衝電場於it 等電場區，且此脈衝電場波形可以是任意的’則各離子所 受的力爲： F(t) = eE(t) 爲了計算方便我們假定脈衝起始時間爲0而截止時間爲 6 ---------C '衣-- * (請先閲讀背面之注意事項再填寫本頁) ..訂 本紙張尺度適用中國國家揉準< CNS ) A4規格（210X297公釐） 3404twf. doo/002 409933 C7 D7 經濟部中央揉率局員工消費合作社印製 五、創作説明（Γ) ti，當_」經塞後名爲： P1 = j0'F(t)dt = J〇'eE(t)dt 因此各離子將县有相同的動量ΠΜ而與質量無關;在此我 們稱本創作之離子源爲定動量離子源裝置21 ;我們可以比 較傳統飛行時間式質譜儀之離子源，如圖一所示，由於其 所有離子皆通過加速區，因此所有離子皆獲得相同動能’ 即B=eV，故可以稱此傳統式離子源爲定動能離子源裝置 11〇 ' 有幾種方式可以#生均勻等霞場乂（1)將電壓施加於兩 個大的平行金屬板上，則此兩金屬板間將呈均勻等電場 區；（2)在以等間隔排列乏圓孔金屬薄板31上施加電壓， 且令所有相臨兩薄板間之電位差皆相等，則此圓孔通道32 上將呈均勻等電場區，如圖三所示；（3)在絕緣之圓形或方 形管41內壁鍍上或塗佈上均勻之電阻膜42，且在此電阻 膜兩端接上金屬薄片或金屬細ϋ 43，當電壓施加於此兩端 金屬上時，管內將形成均勻等電場區，如圖四所示。 現計算定動量飛行時間式質譜儀中離子飛行時間之情 形：假設離子質量爲m，初始速度及位置皆爲0，則其在 均勻等電場內之加速度a(t)爲.： a(t) = ffi=eE(〇 mm 其脈衝結束後(t=ti)之速度爲：Printed by Cl D7 Μ Printed by Zhengong Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs of the People's Republic of China 5. Creative Instructions (>) Time-of-flight mass spectrometer. r Therefore, the main purpose of this creation is to provide a constant-mass time-of-flight mass spectrometer, so that the time of flight of the ions is proportional to the mass of the ions, so that a clear mass spectrum can be obtained with uniform resolution. According to the main purpose of this creation, a constant momentum time-of-flight mass spectrometer is proposed, which includes: a certain momentum ion source device, an ion drift device, and an ion value I device. Among them, the constant momentum ion source device is used to generate ions with the same momentum; the Litzi drift device mm #-定 催 1-the temperature of the child's temperature shifting skeleton generated by the device; and the ion detector is used to detect and record the constant The time required for the ion jade produced by the momentum ion source device to pass the ion drift device. 'In order to make the above and other purposes, features, and advantages of this creation more obvious and easy to understand, a preferred embodiment is given below in conjunction with the accompanying drawings for detailed description' The detailed description is as follows: Brief description of the drawings: ._ Name-one: traditional time-of-flight mass spectrometer; Figure two: constant-moment time-of-flight mass spectrometer; 'Figure three: Uniform equal electric field area with metal holes arranged at equal intervals; Figure four: Uniform resistance film in the tube The formed uniform isoelectric field region; and Figure 5: High-resolution fixed-momentum time-of-flight mass spectrometer. Explanation of the marks in the drawings: I Π, 21, 51: Constant kinetic energy ion source device 1 I 12, 22: Ion drift device 13, 23, 53: Ion detector 5 {Please read the precautions on the back before filling the book Page)-The size of the paper used for this edition is in accordance with the Chinese National Standard (CNS) A4 specification (210X297 mm) 34〇4twf.doc / 〇〇2 409933 C7 D7 Printed by the Staff Consumer Cooperative of the Central Bureau of Standards and Mobilization of the Ministry of Economic Affairs ) 31: Round metal sheet 32: Counterbore channel 41: Insulated round or square tube 42: Resistive film 43: Metal foil or fine metal mesh v 52: Momentum filter Create a schematic diagram of the structure of a constant-mass multiplying-time mass spectrometer. This constant-mass time-of-flight mass spectrometer includes a certain momentum ion source device. 21, an ion drift device (generally no electric field drift device) 22 and一 ION 测测 器 23。 An ion detector 23. Momentum: Ion outfit Tang (21 includes an ion generator to generate ions (not shown h and the same Li-Zi accelerating device (not shown) used to add UE Li Zizi). Momentum ion source Device 2 丨 can provide an ion source with constant momentum. Features> a The length of the uniform electric field is sufficient to allow the ions to be accelerated within the uniform field. The so-called uniform electric field is for space The position _speak_, t's meaning _ stun refers to being uniform at any instant. The weight of the heavy field at the position of Jiang is equal to the direction X). For time coordinates, the intensity of the position of each point can be It is time-varying. If a pulsed electric field is applied to an electric field such as it, and the pulsed electric field waveform can be arbitrary, then the force on each ion is: F (t) = eE (t) For the sake of calculation, we assume that the pulse The start time is 0 and the cut-off time is 6 --------- C '衣-* (Please read the precautions on the back before filling this page) .. The size of the paper is applicable to Chinese countries. ; CNS) A4 size (210X297mm) 3404twf. Doo / 002 409933 C7 D7 Staff consumption of Central Rubbing Bureau, Ministry of Economic Affairs Cooperative printed five. Creation note (Γ) ti, when _ ”is plugged, it is named: P1 = j0'F (t) dt = J〇'eE (t) dt. So each ion will have the same momentum ΠM and It has nothing to do with mass; here we call the ion source of this creation a constant momentum ion source device 21; we can compare the ion source of a traditional time-of-flight mass spectrometer, as shown in Figure 1, because all its ions pass through the acceleration zone, so All ions get the same kinetic energy, that is, B = eV, so this traditional ion source can be called a constant kinetic energy ion source device. There are several ways to # 生 Uniform and other Xia field 乂 (1) Apply voltage to two Large parallel metal plates, the two metal plates will have a uniform equal electric field; (2) a voltage is applied to the thin metal plates 31 with circular holes arranged at equal intervals, and the potential differences between all adjacent two metal plates are equal Then, the circular hole channel 32 will have a uniform equal electric field region, as shown in FIG. 3; (3) a uniform resistance film 42 is plated or coated on the inner wall of the insulated circular or square tube 41, and here The two ends of the resistance film are connected with a metal foil or a thin metal chip. When it is on, a uniform isoelectric field will be formed in the tube, as shown in Figure 4. Now calculate the ion time of flight in a fixed-momentum time-of-flight mass spectrometer: assuming the ion mass is m and the initial velocity and position are 0, its acceleration a (t) in a uniform isoelectric field is: a (t) = ffi = eE (〇mm The speed after the end of the pulse (t = ti) is:
Vi = v(ti) = a(t)dt = — E(t)dt =— 其中常數，爲最後务離子所獲得之動量， 7 本紙張尺度逍用中國國家揉準（CNS ) A4規格（210X297公嫠） --------οII C#先閱讀背面之注意事項再填寫本頁) ΪΤ 3404twf. doc/002 409933 C7 D7 五、創作説明（έ7 ) 此常數由所加脈衝電場所決定。 在ti時，離子之位置爲： s口 S⑻=JJv ⑴ dt = j:E ⑴ dtdt = 士 ]·:Ρ(ί)* 其中 Ρ⑴=^eE(t)dt 離子到達偵檢器的時間爲： L-Si L-兄 i<!Wt)dt ti 4- · ti ^war~«rVi = v (ti) = a (t) dt = — E (t) dt = — where the constant is the momentum obtained by the last service ion, 7 paper sizes are in accordance with China National Standards (CNS) A4 (210X297) (Public note) -------- ο II C # first read the notes on the back before filling out this page) ΪΤ 3404twf. Doc / 002 409933 C7 D7 V. Creative Instructions (7) This constant is determined by the pulsed electric field. At ti, the position of the ions is: 口 口 S⑻ = JJv ⑴ dt = j: E ⑴ dtdt =]] ·: Ρ (ί) * where P⑴ = ^ eE (t) dt The time when the ions reach the detector is: L-Si L-Brother i <! Wt) dt ti 4- · ti ^ war ~ «r
VI p/m (々)+(> 經濟部中央標率局貝工消費合作社印製 即t = CI + C2.m，其中Cl、C2皆爲由所加脈衝電場所決fe 之常數，因此離子飛行時間與其質量成線性關係。 上述所示之直線型離子漂移裝置22亦可改爲外加垂 直紙面之均勻磁場使其漂移軌道呈扇型之動量過濾器 (momentum filter)52，如圖五所不；其中，定動量離子源 裝置51及離子偵檢器53是與圖二中定動量離子源裝置21 及離子偵檢器.23相同。此種動暈過濾器52具有動量過濾 特性，也就是在某一磁Μ > 離子可通過此過濾器而與離子霊離子 ^曼無法通過。由於離子在未被電場加速時，各離子本身就 會具有一些小而不等的初始動量，因此在被脈衝式均勻等 電場加速後，各德子之動量亦因些初始動量而_直皇藍之 分IjJI將響質譜儀呈厘定動量離子源如果配 合扇型動暈過濾器，由於方向 相華直，因此不但仍保，而且可濾 掉ΛΛ4差之離子’避.免兩鄰近質聲波峰这^)間之重疊’ 可大大提高質譜儀之解析度。 (請先閲讀背面之注$項再填寫本頁) 訂 本紙張尺度適用中國國家標準（CNS ) A4说格（21〇><297公釐） 340 4twf. doc/002 409933 C7 D7 五、創作説明（9) 雖然本創作已以較佳實施例掲露如上，然其並非用以 限定本創作，任何熟習此技藝者，在不脫離本創作之精神 和範圍內，當可作各種之更動與潤飾，因此本創作之保護 範圍當視後附之申請專利範圍所界定者爲準。 (請先間讀背面之注意事項再填寫本頁) ¥ 訂 經濟部中央標準局具工消费合作社印製 本紙張尺度適用中國國家揉準（CNS > A4規格（2[0X297公釐）VI p / m (々) + (> Printed by the Shellfish Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs, that is t = CI + C2.m, where Cl and C2 are constants determined by the pulsed electric field. Therefore, The ion flight time has a linear relationship with its mass. The linear ion drift device 22 shown above can also be modified by adding a uniform magnetic field on a vertical paper surface to make the drift track a fan-shaped momentum filter 52, as shown in Figure 5. Among them, the constant momentum ion source device 51 and the ion detector 53 are the same as the constant momentum ion source device 21 and the ion detector .23 in FIG. 2. This kind of kinetic halo filter 52 has a momentum filtering characteristic, that is, in the A certain magnetic M > ions can pass through this filter and cannot pass through the ion 霊 ions. Since the ions are not accelerated by the electric field, each ion will have some small and unequal initial momentum, so it is being pulsed. After the formula is uniform and the electric field is accelerated, the momentum of each virtue is also due to some initial momentum. Not only guarantee, but It can be filtered out of the difference between the ion ΛΛ4 'avoided. Free sound quality two adjacent peaks which overlap ^) between the' can greatly improve the resolution of the mass spectrometer. (Please read the note on the back before filling in this page.) The size of the paper used for this edition applies to the Chinese National Standard (CNS) A4 format (21〇 > < 297 mm) 340 4twf. Doc / 002 409933 C7 D7 V. Creation Note (9) Although this creation has been shown above with a preferred embodiment, it is not intended to limit this creation. Anyone skilled in this art can make various changes without departing from the spirit and scope of this creation. And retouching, so the scope of protection of this creation shall be determined by the scope of the attached patent application. (Please read the precautions on the back before filling in this page) ¥ Order Printed by the Central Standards Bureau of the Ministry of Economic Affairs and printed by the Industrial Cooperative Cooperative This paper size is applicable to the Chinese national standard (CNS > A4 size (2 [0X297mm)