TW386033B - A skin permeant pharmaceutical compositions - Google Patents

Description

Printed by the Central Bureau of the Ministry of Economic Affairs, Shellfish Consumer Cooperative, A7, B7, Amendment 6 Supplement * V. Description of the invention (58) Hyaluronic acid sales 0.1% by weight, methyl paraben 0.1% by weight, glycyrrhizic acid 0 0 1% by weight 3-L-MP 0. 05% by weight purified water 7 ». 74% by weight of children. 混 Mix and mix the above ingredients, impregnated with non-miscellaneous cloth, g is set with a release film. It is cut into a predetermined shape to prepare an impregnated sheet-like bagging agent. Yingyingli 82 Scooping-type castrated polyvinyl alcohol 20 · 0% by weight Carboxymethylferricin 3.0% by weight Child gasified titanium 8. 0% by weight 1, 3-butanediase 5.0% by weight Triacontane 3.0% by weight POE (10) nonylphenyl ether 0.5 reset% methyl parahydroxybenzoate 0.1% by weight calcified phenol 0.0% reset by 3-L-MP 0. 1% by weight of purified water 60. 29% by weight Search and mix the above ingredients to prepare a peeling bagging agent. th Comparative Example 7 Milky Bagging Agent Except that 3-L-MP was not mixed, the same mixing and cracking method as in Example 41 was used to prepare a milky bagging. fch Comparative Example 8 Except that 3-L-Μ P is not mixed with the viscous pouch type, the same mixing and preparation method as in Example 80 is adjusted to -60- (please read the precautions on the back before filling this page) Paper size is in accordance with China National Standards (CNS) A4 (210X297 mm) printed by the central ministry of the Ministry of Economic Affairs and consumer cooperatives A5 _ B7_ V. Description of the invention (1) [Industrial fields of use] The thinner is used in addition to a dissolving agent containing an active ingredient and the dissolving agent. In detail, it is used as an effective ingredient for percutaneous absorption such as porridge (cataPlasBa) or as a solution for chrysanthemum fat-soluble powder. It has excellent solubility of active ingredients, high safety, and good stability. * Compatibility, meanwhile, it is a dissolving rainy screen that has no odor and is clear, and thinner for external use containing the dissolving agent. [Existing Technology] In the past, various methods have been tried to collect medicines as percutaneous waste and hope to obtain a therapeutic effect. The main issue of this kind of percutaneous animal husbandry is how to efficiently raise the base of the drug (the effective ingredient), that is, transfer it from the base cocoon of the drug to the skin. In general, when a certain cocoon is used to try to design a cocoon, due to insufficient dissolution of the drug in the base, crystallization, etc., it is possible to reduce the exudation of the cocoon and rarely obtain sufficient therapeutic effects. Among them, the most suitable dissolving agent for tincture is the main factor in the design of the formulation. Due to the choice of the dissolving agent, the dissolution of the tincture is insufficient, which reduces the release from the base agent and is widely used in the affected part, and cannot be used. Play a considerable therapeutic effect β Nowadays, it is used as a drug to dissolve, including alcohols, adipic acid, some of the interfacial activity is thin, essential oils such as peppermint oil, lactone, methyl hydrolysate, water Fatty acids represented by adipic acid, myristic acid, propyl ester, etc. "For example, hold open © 56- 1 54 4 1 3M Bulletin states that the phenanthrene» Flubiprofen is dissolved in the pinene substance or Fatty acid esters, from the beta ratio in the paper size (CNS specification (210X297 mm)--Γ. Please read the note f on the back before filling out this page) Order-Correct # #Each 4. Contains, belongs to A7, supplement B? 5. Description of the invention (slave) Test example A (piper safety test) For porridge cocoons of Examples 1 to 4 and Comparative Examples 1 to 3 • Peel safety Test "Let the 25 males and females of Kang Zhi conduct the Fengming-style sigh test. From time to time, the degree of change of Pirup was evaluated according to Biaohua. The degree of agitation is shown in Table 3 ~ 4.--There is a change in the appearance of Pi Xiong. A thin red ++ appears on the skins: there is a heavy spot on the skins. Table 3 (# ¾¾ Note from this book? Yuan? Help? The rate of stamping is Λ Workshop Fee Cooperative Cooperative «. Lili Evaluation of the subsequent experience time + + + Total number of persons (person; Sexual slaughter (% > 1 hour or more) Implementation 1 0 0 0 25 25 0.0 1 hour Example 2 0 0 1 24 25 4.0 1 hour Planing 3 0 0 0 25 25 0.0 1 Small Example 4 0 0 0 25 25 0.0 1 hour comparison #i 1 0 0 2 24 25 8.0 1 hour comparison for 2 0 0 1 24 25 4.0 1 0 0 3 25 25 12.0 -63- order-good. This paper size is based on China National Standards (CNS) A4 (2 丨 0X297 mm) Printed on the AFC _B7_ V. Description of the invention (2) Medium oil type emulsified thin water-based base is thinly cracked into external anti-inflammatory and analgesic _, Special Publication No. 5 * 7-98209 records that IndoBetacin is dissolved in mono-enzyme and multi-enzyme Anti-inflammatory and analgesic preparations for external use only have such thin dissolution, insufficient solubility and precipitation of crystals, and their use is limited due to the smell. Due to the poor compatibility of the base group, flocculation occurs, which may cause aging. Stability problems such as disintegration or coloration, meanwhile, the discomfort of dissolving the irritated skin with irritated skin and causing side effects such as quick eaves, etc., is not very satisfactory. "Intentional results β On the other hand, although it is tried in porridge Contains fatty powder or water-insoluble powder (hereinafter abbreviated as fat-soluble powder) for use, but most of the porridge is usually a water-soluble base, so it lacks solubility in fat-soluble powder. Dissolved in base, or existed in a dissolved state during manufacture, but still has the problem of stability of crystal precipitation over time. [Problem to be solved by the invention] The object of the present invention is to solve the above problems and provide A dissolving agent with excellent dissolving effect of active ingredients, safety, stability, discompatibility, and an external use containing the dissolving agent [means for solving problems] The present invention Purpose, because the use of 3-L-2 oxypropane-1, 2-diferment (referred to as 3-L-MP) as the active ingredient of solubilized Erin can be linked to β, that is, in the present invention, you use 3- LI gas-based propane-1, 2-dienzyme (3-L-MP) is a dissolving active ingredient, and a preparation for external use containing the solubilizing agent and the active ingredient. The effective ingredients used in the present invention refer to the medicinal paper used for transdermal absorption. ”• Standards in use • National rubbing standards (CNS > Α4 size (210X297 mm) Alignment-A7 B7 revised version on January 1, 2005. Description of the invention (62) Elapsed time evaluation sample after the table is peeled + + + Soil-Total (person) Property rate (%) More than 24 hours to implement Example 1 0 0 0 25 25 0.0 2 4 hours Example 2 0 0 0 2 5 25 0.0 2 4 hours Example 3 0 0 0 25 25 0.0 2 4 hours Example 4 0 0 0 25 25 0.0 2 4 hours Comparative Example 1 0 0 1 24 25 4.0 24 hours fcb comparative example 2 0 0 0 25 25 0.0 2 4 hours comparative example 3 0 0 1 24 25 4.0 Please A Η A of · Notes and f The porridge preparations of Examples 1 to 4 are extremely safe for skin test. Example 4 (Percutaneous Absorption Test on Humans) The specimens of Example 4 and Comparative Example 2 were punched into 3X3C · 2 and attached.

On the upper back of 8 healthy volunteers, they were recovered after 8 hours, and they were disabled children according to HP LC \ Legal Ketone Pufan (Uetoprofen). The absorption rate of the human body • Conversion of *, method of determination and HPLC conditions are as follows: ⑴ Yield of the human body = (1-residual initial content) X100 ： Dingli method: the recovered sample is 70b1 in alcohol. After performing reflux extraction for 2 hours, the 100 · 1 formazan after extraction was used as the sample for HPLC · -64- This paper size is in accordance with China National Standards (CNS > Α4 size (2 丨 0X297 mm) \ Economy The Ministry of Economic Affairs and the Ministry of Economics and Industry Cooperative Cooperative Printing is printed by the Ministry of Economic Affairs and the Ministry of Economic Affairs and the Ministry of Economics and Economics. It is printed by the Ministry of Economic Affairs and Consumer Cooperatives «. A7 B7 V. Description of the invention (3) Ingredients or porridge _ Fat-soluble powder used" > 3 used in the present invention -Li (P is a conventional substance, for example, a substance with a cooling effect described in Japanese Patent No. 58-88 3 3 4. Japanese cosmetic No. 60- 2 5 90 8 describes a cosmetic with excellent wave-clearing effect. Pirup has a very high level of safety. However, there are no examples of using this substance as an effective ingredient to dissolve the active ingredient. Moreover, the trial of dissolving this substance to absorb the effective ingredient through the skin was first discovered by the inventors. , Is a new insight. Μ in the present invention percutaneous absorption of 3-L-MP, The total amount of external preparation is 0.001 to 20% by weight, preferably 0.1 to 10% by weight. If the content exceeds 20% by weight, it is quite good. Difficult to obtain stable preparations "There is no particular limitation on a transdermal absorption active ingredient used in the external preparation of the present invention, and any one of the conventionally known drugs & ingredients" such an active ingredient can be used in accordance with this, Examples are predinisolone, dexaaethasone, hydrocortisone, fluocinolone acetοnide, valeric acid bethaaethasone, and meda dipropionate. Dipropionic acid bethanethasone}, butyric acid clobetasone, succinic acid prednisolong and other steroidal anti-inflammatory agents, such as indo »etacine , ≪ 1 ie 1 〇fenac}, ibupr 〇fe η >, fcetoprofen, fluphenanic acid, Kotorak, Frou Birprofen (flurbiprofen) The ruler is used in accordance with the Chinese National Standard (CNS > A4 size (210X297 mm) (Please read the precautions on the back before filling out this page) Order 8310428491 ♦ Case Study i ^ Supplementary Example of Skin Absorption Test Test method for percutaneous absorption test of eel on the forearm of 5 healthy adults. A white plaque of 1.4X 1.4ca was made with white petrolatum. In this plaque, Examples 69, 73, and 74 of the liquid preparation were microinjected. The preparation of the non-sealed coating part of the cylinder was inserted into a 25ml flask, and the washing operation was performed immediately after repeated washing and recovery operations. The volume was fixed at a fixed volume, and then placed in a test tube with a supersonic receiver, and each was coated with 20 w 1. 'Alcohol and water (1: 1. Set the leakage from the funnel 3 times to become the recovery liquid. As the initial content. Add 50 «overnight after 1 hour of echo treatment, and it will remain after t hours) Wipe the gauze wipes 3 times with buckets and inject alcohol with the Aioka method to apply and collect the solution with alcohol and leave it at 25. A 1-bl alcohol solution of quasi-substance was taken. After ACROLC 13 was filtered, the drug was measured by HPLC under the conditions shown below, and the percutaneous absorption (rate) was calculated from the residual amount.

Conditions for HPLC • _ Pump: Model 60C0A (Waters) Injector ODS-60TM (T0S0) 4.6mtfn XD # > < 15cm (5pm) Mobile phase: Acetate buffer (pH 3.2): CH ^ CN = Flow rate: 1.0 ml / min UV detection; 254 nm Column temp *: 35 * C Printed by the Central Government Bureau of the Ministry of Economic Affairs, Shellfish Consumer Cooperative A7 __ £ 7 _-_ V. Description of the Invention (4) Fen, Plagen Proven (9 ^ 11〇91 > 〇 {811), If ), Roche Prufen, Tinitab, and other non-steroidal anti-inflammatory agents and their ester derivatives, tranilast, Azeroth, ketotifen, clothing Prasat, Emerasian and other anti-mutagenic diphenhydramine (chlorinearamine), chlorphearaaine, pr'o ^ ethazine, tripyramine (Tripelenaiine) and other antihistamine cocoons, ch 1 〇rpr 〇azine >, Nitorazeppan epa >, diazepa, diazepa, phenobarbital, Ueserpine, etc., nerve function, insulin, lipid M (testosterone), norethisterone (norethisterone), Methyl-estrone (· β1; 1ΐ3Γΐ testosterone), progesterone, «Estradiol and other hormones, cumulone, reserpine, guanethidine sulfate, etc. Anti-hypertensive agent, digital heart toxin (digitoxin), digoxin (digoxin) and other strong heart palpitations, propranolol hydrochloride, procaine and IK (procainaaide hydrochloride) , Anti-impulsive agents such as ajaaline, pindolol, nitroglycerin, isosorbide dinitra / e, papaverine hydrochloride, depending on Coronary vasodilators such as nifedipine, lidocaine, benzocaine, procaine hydrochloride, tetracaine, etc. This paper is standard for China Furniture Standard (CNS) Λ4 specification (210X297 mm) (please read the note f on the back before filling in this card) Order the Central Government Bureau of the Ministry of Economic Affairs * Cooperative printed A7 B7 V. Invention Description (5) m taste (ο r P hine), aspirin β (as Pr η), codeine (C odeine), acetanilide (acetani 1 id), aminopyrine (ai η opyrine) and other mineral pain Er, Ibexicone < eperioone >, Zazaritan, Tolperisone, Ininabyl, Puli Yeast and other bones are too slow, ethyl brewed benzylamine. (Nitrofurazone) 〆 五 徽 素. (Pentaiycin), naphthyliate, miconazol (ic ο na ζ ο 1), »Maconazol, Kusamazol (c 1 〇11» ia ζ ο 1 e), antifungal agents such as wolfofine hydrochloride, sulozole, buprofen < 5-fluorouracil), busulfan, actinoayciu, mitotic Anti-malignant tumor-reading agents such as Huisu, urinary incontinence agents such as ferrozine hydrochloride, oxybutyrin hydrochloride, nitrazepa ·, mepolopam EeprobaBate, aatiepi 1 epticagent, qi 1 ozr ζ ο X a ζ ο ne, Lipoduba and other anti-parkinson's disease agents (autiparkinson's diseases agent), nicotine (Nicotin) and other non-smoking subsidies, including biotics, prostaglandin (Prostaglandin), etc., of course, there is no restriction on the dosage form of the transdermal garbage collector of the present invention. The thin type used in the past for external application, such as porridge cocoons, bud-releasing cocoons, glues, * milk thin, cream-like emulsions, liquids, mists, reserves ^ attach agent, rubbing and other percutaneous forms Secondly, the application examples of the transdermal garbage collection of the present invention are described one by one with porridges »code hard buds. -7- (Please read the notes on the back before filling in this page)

C Order-Sound-This paper size is in accordance with China Standards (CNS) M specifications (210X297 mm) Printed by the Ministry of Economic Affairs and the Consumers Cooperatives A7 Β7 5. Description of the invention (6) For example porridge rain For Kalou and its stability over time, transferability, transdermal garbage collection, skin safety, water-soluble ionomer multivalent enzyme and water as the base rain to form a hydrophilic base and a thin hydrophilic base For the use of water-soluble ionomers for scars, it is suitable to use Mingmiao, casein, post-coagulation, refining, sodium diatomate • soluble starch, _-based starch, dextran carboxymethyl followin, carboxymethyl follow Suturin, Polyvinyl Yeast, Polyethylenethane, Polyacrylic Acid, Polyacrylamide, Polyacrylic Pin, Polyvinylpyrrolidine, Carboxyvinyl Polymer, Polyvinyl Ether, Methyl Ethylene Maleic Anhydride Copolymer, Isobutylene One or two or more of maleic anhydride copolymer, N-vinylacetin, N-ethylacetamide and acrylic acid and / or acrylate copolymers shall be selected. At this time, the compounding amount of water-soluble polymer is 1 to 30% by weight of the whole system, the next best is 1 to 20% by weight, and the best is 1 to 15% by weight. »If less than 1% by weight Then its viscosity becomes low and its shape retention cannot be preserved, and when it is more than 30% by weight, its viscosity becomes off, which reduces workability during kneading or coating. Multi-fermented yeast can be obtained from glutarate, malonate, dimalonate, polymalonate, 1,3-butanal, 1, 4-butanal, isobutanal, glycerol, diglycerol , 1 type of sorbose, or 2 or more types can be selected if necessary, and its mixing amount is 10 ~ 90 weight] 19U, preferably 10 ~ 70% by weight, and most preferably 20 ~ 60% by weight » If it is less than 10 weight percent, its maintainability is insufficient, and when it is more than 90% by weight, it has an influence on the solubility of the water-soluble mash ^ The mixing amount of water is 10% by weight, preferably 20%. 80% by weight, dissolves the water-soluble polymer, and reveals its thickening, coagulating, and shape-preserving properties. -8-This paper is used in China National Standard (CNS) A4 specification (21〇 > < 297mm) ---_------ ^-. Packing-*-(Please First read the note on the back of the page.

I A7 _ B7___ V. Description of the invention (7) Furthermore, depending on what is needed, add the necessary ingredients and use polyvalent metal compounds as the cocoon. In particular, it includes argon "molybdenum, cyanide" Krypton, argon "Hydrogenation 0, ammoniation 0, aluminum sulfate, giant sulfuric acid, potassium sulphate, magnesium molybdate silicate, dihydroxyaluminum aminoacetate, etc., and the other interfering substances are at least in the molecule. There are more than 2 plums of "base compounds; specifically, including ethylene glycol bis-acetylglycol_, polyethylene glycol bis-β-ethyl acetate, malonyl bis-ethyl acetate, polypropylene Yeast 2 "Ethyl Ethyl Ether, Polytetramethylene Ester Diamino Ethyl Ether, Glyceryl Polyamino Ethyl Glycogenate, Sorbitan Anhydride Poly Ethyl Glycol Ether, Trimethylol Propane Ethylate , Pentaerythrogenic enzyme polyaminoethyl ether, hydroquinone diamino methyl ether, neopentyl ethylene diamino methyl ether meter, 1, 6-hexene diamino diamino ethyl ether, etc. It is suitable to mix one or more cross-linking agents ^ In addition, the other may be admixed with fillers such as liolin, gasified zinc, titanium, ceramic, diatomite, synthetic aluminum silicate, etc., hundred in Preservatives such as phenol, methyl parahydroxybenzoate, ethyl parahydroxybenzoate, vitamin C, stearates, dibutyl hydroxytoluene, butyl hydroxytearyl ether, gallic acid esters, vitamin pentamate, biotics Anti-gasification 2-hydroxy-4-methoxybenzophenone, pentylacetate, ethylenediaminetetraose, etc., 2-ethyl 2-benzylbenzoate, 2- (2-hydroxy-2-toluene) benzo Triazole, oxalic acid salicylic acid, salicylic acid, formic acid, salicylic acid, etc. UV, sorbitan fatty acid_, glyceryl fatty acid sugar, decyl glycerol fatty acid, polyethylene vinyl sorbose One or two or more kinds of emulsified thinners such as enzyme fatty acid esters, polyethylene glycol fatty acid esters, and polyethylene gas alkyl ethers. The support of this congee is important. It is important that the paper does not affect the medicinal ingredients of the thin paper. The paper uses China · Jialiang Zhun (CNS > A4 size (210X297 mm)). Note! Printed by the Ministry of Economic Affairs and the Consumers Cooperatives of the Ministry of Economic Affairs and printed by the Central Ministry of Economic Affairs and the Consumers ’Cooperatives of the Ministry of Economic Affairs, printed A7 and B7. 5. The material of the invention description (8). It is suitable for suckers. For example, you can choose polyethylene, polypropylene, polyvinyl chloride, polyester, sleep-resistant, polyurethane, etc. films or materials, or porous foamed cloth, cloth, non-iron cloth. It can also be porous film, foamed film, cloth, and non-iron cloth for its film or material. Also, peeling off the articles can be made ». · Probing polyethylene, polypropylene, polyester or Release processing or peeling paper with sand ketone, etc. "Secondly, the manufacturing method of this porridge is explained, and it can be easily manufactured by the conventional manufacturing method." For example, (A) dilofenac ), Ketoprofen, ketoprofen, fluphenanic acid, tinitab, Luo Profen, Kotorak, Fubinac, Sprufen, indonetacine and its ester derivatives or _ non-steroidal anti-inflammatory and analgesic drugs as effective ingredients can be used 3-L- MP to dissolve. ”If necessary, add stabilizers, anti-chemical agents, UV absorbers, emulsifiers, preservatives, antibacterial agents, etc. (B) Water-soluble polymers are mixed with multiple enzymes, water, dispersed and dispersed. Dissolve and form into a homogeneous kneaded material. Next, add (B) to (Α) to disperse and directly extend to the support 臛, or extend it to the paper or film that has undergone the peeling treatment, and then rewrite it with salt. Supports brewing and can be added to manufacture. In addition, the above-mentioned manufacturing method is based on thin, medicinal ingredients or other ingredients in the order of mixing, that is, the example is summarized, but the mixing order is not limited by it. Fenlian Li 1 Congee thin (A) This paper size is applicable to China National Standard (CNS) A4 size (210X297 mm) (Please read the note f on the back before filling this page) Order A7 B7 V. Description of invention (9) 3- L-MP 1.0 reset% dilofenac 0.5% by weight (B) fine Water production 48.5% by weight Waist 8 • 0M Amount% Liolin 1 • 0% by weight Glycerin 35.0% by weight Polyacrylic acid sodium 2.0% by weight Polyvinyl alcohol 3.0% by weight Aluminium hydride 1 • 0 Dissolve the above ingredients by stirring 9% to obtain a homogeneous kneaded material. Use a spreader to coat it on a polypropylene non-woven cloth with a thickness of about 1 cup, and then cover it with a polypropylene film 9 and cut to a predetermined size. Formulation A S. Example 2 Congee (A) 3- L-MP 2 • 0 weight JS% Rochprofen 1.0 weight *% thymol 0.1 weight% (B)! Purified water f 62. 4 resuspension% sleep. J · 3 • 0 reset% titanium vaporized 1 • 0% by weight glycerol 25 • 0% Λ sodium polyacrylate 3.0 % By weight Printed by Zhengong Consumer Cooperative, Central Bureau of Standards, Ministry of Economic Affairs.,-C (please read the precautions on the back of the book before reading the book I) -11- This paper size applies to China National Standards (CNS) Λ4 specifications ( 210X297mm) A7 B7 V. Description of the invention (10) 1.0% by weight 1.0% by weight 0.5% by weight 5% Using a stretcher to read 3.0% by weight (please read the precautions on the back before reading) (Fill in this page) Carboxymethylazine diaminoethane diethyl ether ether sorbitan fatty acid ester dissolves the above ingredients, stir to obtain a homogeneous kneaded material coated on polysaccharides, the thickness is about 0.5 »,, Then, it was covered with a vinyl film, cut to a predetermined size, and made into a preparation. Fen Example 3 Porridge (Α)

3-L-MP 0.5% by weight 0.2% by weight Dong 42.3% by weight 5.0% by weight 3.0% by weight 40% by weight 2.0% by weight 2.5% by weight 1.5% 5% by weight ibupr 〇fe η ethyl paraben (B) Custom-made water spring _ methoxyethylene maleic anhydride copolymer synthetic aluminum silicate polyacrylic acid polyacrylic acid polyethylene fermentation Vaporization 0 The Central Kneading Bureau of the Ministry of Economic Affairs only prints and dissolves the ingredients on the top of the consumer cooperative and stirs them to obtain a homogeneous kneaded material. Using a spreader, it is coated on a polyurethane film with a thickness of about liw. Cover it with a polyester film and cut it into a predetermined size. g Example 4 Congee (A) -12 The paper size is in accordance with China National Standards (CNS) Λ4 specification (210X297 mm) A7 B7 (first read the "$" on the back and fill out this page) Order the Ministry of Economic Affairs Printed by the Central Consumers' Bureau of Industrial and Consumer Cooperatives 5. Description of Inventions (11)

3-L-MP ketoprofen (B) Refined water N-ethylene acetoamine glycerol polyacrylic acid carboxymethyl weavesin silicic acid magnesium magnesium glycerol fatty acid ester Dissolve the above ingredients, stir It was coated on a polyester cloth, cut to a predetermined size, and made into a comparative example. 1 Congee (A), kutamine, sporofen (B), refined hydrangea soap Naglycerol Alginate Sodium Polycyclic Gas Ethylene 2.0% by weight 6% by weight D. 5% by weight 36.0% by weight 5.0% «% 50.0% by weight 3.0% by weight 1.0% Μ% 1 5% by weight 1.0% by weight to obtain a uniform kneaded product. Using a stretcher, the thickness is about 1 丨 丨, and then covered with a polyester film. 1.0% by weight 0.8% by weight 54.2% by weight #. 6.0% by weight 5% 5.0% by weight 25.0 Weight% 2.0 Weight ft% 4.0 Weight% -13- This paper is again applicable to the Chinese National Standard (CNS) A4 (210X297 mm) 5. Description of the invention (l2) A7 B7 Central Ministry of Economic Affairs The local shellfish consumer cooperative printed the aluminum sulfate polyethylene glycol fatty acid ester to dissolve the above ingredients, stir to obtain a uniform kneaded material coated on a polyvinyl cyanide film with a thickness of about 0.3, cut to a predetermined size, and prepare a preparation β fcb » Example 2 Porridge 1 «(A) Ketoprofen (B) purified water N-ethylene acetamide glycerol fatty acid cool glycerin polyacrylic acid carboxymethyl cellulose magnesium aluminosilicate dissolved The above ingredients are stirred to obtain a uniformly kneaded material having a thickness of about 1 on a polyester cloth, and then coated to a predetermined size to prepare a preparation. t: h Comparative Example 3 Porridge (A) Butene ethylene glycol peppermint oil 1.5% by weight 0.5% by weight JK%, using a stretcher to cover it again with polypropylene 禊 2.0% by weight Dong 0%. 5% by weight 36.0% by weight 5.0% by weight 1.0% by weight 50% by weight 3.0% by weight 1.0% by weight 1.5% by weight. Use a stretcher to coat the cover with a polyester film and cut off 4.0% of the weight% 1.0% of the weight%% Please read the note on the back side first-item again% of this page Standards (CNS specifications (210X297 mm > A7 B7) V. Description of the invention (Engineering 3) Qi Pu Lufen 0.5 weight% (B) «1 water production 47.5 weight director% gelatin 3.0 weight% Liloline 1-ok Μ% 甘 _ 油-35 · 〇 heavy cover% polyacrylic acid m 3.0% by weight carboxyethyl acetate, polymer 2.5% by weight% period fines 2.0% by weight sorbic anhydride polymide Acetyl acetate 0.5% by weight of the above ingredients dissolved »Stir well to knead the mixture 9 Use a spreader to coat the polypropylene non-woven fabric with a thickness of about 1 醐 > Then cover it with a polyester film 9 and cut to a predetermined size Size > Formulations 0 and 9 Mixture of plaster can be used, for example (a) die 1 〇fe na c »face Λ (k; et op» r 〇 • fe, n) »F1ur b ip fen 0 fen» mention Nitab »Roche Prufen, Kotorak» Fcb-rich $ Sprofen and its ester derivatives or salts as non-steroidal anti-inflammatory analgesics 9 (b) and rosin ester derivatives And 3-L-MP dissolve. (C) Using styrene-isoprene-benzyl ethylene segment copolymer as the basic polymer Z propylene strip adhesion »((〇from softening 剤Or in the conventional plaster cocoon base, you should choose the recipe. The plaster's support can be made of polypropylene cloth or polyester cloth that has no effect on the released non-steroidal anti-inflammatory and analgesic ingredients. The cloth is best made of PET (polyethylene terephthalate) or PBT (polybutylene terephthalate) $ -15- This paper size is based on Chinese national standard (CNS > A4 size (210X297 mm)) The Central Bureau of the Bureau of Shellfish Consumer Cooperation Du printed A7 _B7_ 5. Description of the invention (14) Fabrics made. To improve the release of non-steroidal anti-inflammatory and anti-inflammatory analgesics, it is advisable to support the non-interaction between non-steroidal and anti-inflammatory anti-inflammatory analgesics, that is, to not absorb the active ingredients as a necessary condition. From the perspective, the most suitable support for the sickle polymer composition is polypropylene, PET or PBT. And because of the use of polypropylene, PET or PBT to form a support brew, often because the support does not absorb effective ingredients, so it shows good release. This kind of hard bud has a stretchability of 0.3 kg / c · or less when the 50% elongation in the building direction is used, so it can be attached to the flexion, which is not only easy to use, but also « Extending and entanglement with the skin, reducing the friction and oppression side effects of capital occupation. "About this hard bud, the special excitement it manifests is, through Songfan 08 $$ 物 and 3-L-MP 的Mixing at a specific ratio can greatly improve the solubility of the active ingredients. Time can greatly improve the release of effective ingredients. Among them, _ & ingredients, for example, fully dissolve the non-steroidal anti-inflammatory mineral pain medicine, which constitutes tt · its non-steroidal anti-inflammatory mineral pain medicine / rosin brewer derivative / 3-L-MP is 1/2 to 25 / 1 to 10 (weight ratio), which shows good solubility and release properties of non-steroidal anti-inflammatory and anti-inflammatory drugs. Among them, rosin sugar derivatives are made by esterifying various rosins, adding water or refining. Depending on the type of ester, there are methyl esters, glycerol esters, pentaerythritol esters, etc. In terms of skeletons, there are _骥 丸, AA-G, Η, HP (produced by Arakawa Chemical Co., Ltd.), Perth Essence-L, S, P (manufactured by Harima Chemical Co., Ltd.), and ester A-75 (manufactured by Arakawa Chemical Co., Ltd.) , KE-311 (manufactured by Arakawa Chemical Co.), Harcolin D (manufactured by Hercules >), Euler 85, 105 (manufactured by Hercules), etc. -16- This paper Standards and Standards for National Standards of China (CNS) Λ4 (210X297 mm) (Please read the note f on the back before filling in this card) Order the Central Ministry of Economic Affairs' shoulder-shoulders consumer cooperative print A7 B7_ V. Invention Explanation (Η) The basic polymer of this plaster is based on the safety of Kalou and Pirup, the release of medicinal ingredients, and its susceptibility to dermatological considerations. The release of non-steroidal disappearing analgesics is yet to be determined. It is better to use a low-polar styrene-isoprene-styrene segmented copolymer. There are Gary Flix TB-llflt, ΪΚ-1111, TRM112, TR-1117 (manufactured by Shilu Chemical Co., Ltd.), Solvail 4 28 (manufactured by Mili Deluer Co., Ltd.), etc. "As mentioned above, although The best example is using styrene-isoprene-styrene segmented polymer, but it can be used in combination with polyisobutylene. The softener is to separate the styrene-isoprene-styrene of the base polymer. Para-copolymers can be plasticized and softened to maintain moderate adhesion to the skin. For such softening, almond oil, olive oil, camellia oil, persimmon oil, peanut oil, flowing paraffin, etc. can be used. 10G parts by weight of ethylene-isoprene-styrene segmented polymer is preferably 150 ~ 350 replacement parts. Although the mixing amount of the effective ingredients is not particularly limited, it is based on the release of the effective amount during the treatment. , The consideration of utilization rate is preferably 70 ~ 1200 // g / c · 2. 鼸 These medicinal ingredients, pineoperyl derivatives, 3-L-MP, styrene-isoprene-benzene The best mixing ratio of each component in the total amount of ethylene segmented copolymer and softener is as follows. That is, the best mixing For example, the effective ingredient is ~ 10% by weight%, rosin ester derivative is 5 ~ 70% by weight, 3-L-MP is 0.5 ~ 15% by weight, styrene-isoprene-styrene segmented copolymer 5 ~ 40% by weight, softened by 10 ~ 75% by weight. This plaster can be easily obtained by conventional manufacturing methods, such as -17- this paper size (CNS) Α4 size (210X297) (Mm) IIII —I —I— I (please read the note on the back and fill in this page first)-order A7 B7 mixer, add mixed medicine effect to the segmented copolymer or not too bad, with the required support The range of internal agents, gasification antiamines, anti-corrosive styrene segmented copolymer V. Description of the invention (16) Use a kneader, mixer, etc.-isoprene-styrene to heat and mix, and then Add it to the paper ghost or film of polypropylene or poly woven cloth and cover it without damaging the purpose of the present invention, such as stable ultraviolet light, thin film, anti-assembly promotion, etc. vmm 5 plaster thin styrene-isoprene Diene-polyisobutylene tackifier (rosin ester)

Flowable paraffin 3-L-HP ketotifen 120 ~ 160 将, directly extend or overlay styrene softening and rosin ester-derived components with 3-L-MP to hold or transfer through release treatment From 箸, add the reasonably acceptable ingredients, spices, filling, thin, anti-_, or percutaneous absorption 22.5% by weight 5.0% by weight 1 5.0% by weight 56.0% by weight 1 0% by weight% 0.5% by weight The central government of the Ministry of Economic Affairs prints for the Zhengong Consumer Cooperative to heat and mix the above ingredients and spread them on the support to make it into a product containing Ketotifen膣 带 mm me Hard Bud Thin Acrylic Resin Strip Solvent Type Pressure Adhesive_ # 77.0wt% Mo (Product Name: NISSETSU PE-300) '(Converted to solid content) 3-L-HP 15.0 wt% Double sorbitan 8.0 wt% Blend the above ingredients, extend it on the support, evaporate and dissolve thin I. The paper size is in accordance with China National Standards (CNS > A4 size (210X297 mm). 5 、 Invention taxation (l7) A7 B7 鼸 Made with iso-nitrate sorbitan glucosamine tape 〇Window〇7_ Plaster »Sand_Adhesive thin 8 9.0% by weight (brand name: bio-psa X7- 292 0) (converted to solid content) 3-L-HP 7 · 0M Λ% cumanis 4.0% by weight Stir and mix the above ingredients to extend it to the support waist The solvent was evaporated to prepare a medicated sleeping tape containing kuranuishen. Fcfc Example 4 Plaster_silicone_adhesive 96.0% by weight (trade name: NISSETSU PE-300) (converted to solid content) kuranuishin 4.0% by weight of the above ingredients are stirred and mixed, extended on a support tincture, and the solvent is evaporated to prepare a drug containing cumani, which is used in Example 7. Except for the solvent 3-L-MP, it is used for comparison. Example 1. Please note first

I

Ordered by the Central Ministry of Economic Affairs, Japan, Japan, and Japan, printed by hh »Example R Silicone Adhesive (BIO-PSA X7-2920) Isopropyl myristate 祜 Raunishen 89 · 〇 Reset% (conversion Solid content} 7.0% by weight% »4.0% by weight% The above ingredients are stirred and mixed, extended on the support waist, evaporated to dissolve, and prepared into a belt containing cumani miracle medicine. In addition, the dissolution of Example 7_ 3-L-MP was replaced by isopropyl myristate as a comparative example 2 ^ Example 8 Hard sound sheet 19 This paper size is in accordance with China National Standard (CNS) A4 (2 丨 0X297 mm) )% Α7 Β7 V. Description of the invention (18) 25.0% by weight 59.0% by weight 5.0% by weight • v 10.0% by weight% styrene-isoprene-benzene-styrene-block copolymer (commodity Name: Gary Fricus TR_1107) Flowing stone iron rosin derivative

3-L-HP diclofenac 1 · 〇 簠% by weight The above prescription is mixed with a kneader and then directly stretched on the PBS cloth, and the upper part is covered with M to make a plaster. Hard bud styrene-isoprene-styrene segmented copolymer 20.0% by weight (Trade name: Gary Fricus TR-1107) 43.5% by weight 10.0% by weight 21.5% by weight- ': ·. C (please read the note f of the note * and then write this page on Qin). Flowing stone polyisobutylene (trade name: Pistacast). Pinosyl derivative (trade name: ΚΕ-311 ) 3-L-MP 4.0 wt% diclofenac 1.0 wt %% Printed by the Bakery Consumer Cooperative of the Central Rubbing Bureau of the Ministry of Economic Affairs, mixing the above prescription with a blender and extending it in advance The absurdity of the male exfoliation process is covered with a PET cloth and pressed to transfer it to make a thin plaster. Β Example 10 Plaster _ styrene-isoprene-styrene segmented copolymer 21.0 weight ％ (Trade name: Gary Flicks TR 1107) Flowing stone 63.0% by weight. This paper size is suitable for B countries (CNS > A4 size (210X297 mm)) Description of the invention (19) A7 B7 rosin ester derivative (trade name: 0-311) 3-L-MP diclofenac Mix the above prescription with a kneader and extend it to a pre-applied to peel off The processed plastic film is covered with PBT non-woven fabric and pressed into the upper part to make a hard bud. Fen Shi 桷 11 Plaster styrene-isoprene-styrene segmented copolymer 30.0% by weight (brand name -Gali Filicus TR 1111) Flowing stone rosin ester derivative (trade name: Brewing error H) 10.0 weight ft% 4 .0 weight% 2. 0 weight% (please read the "$" on the back side first) Please fill in this again) The central sample rate of the Ministry of Economic Affairs is printed on 3-L-MP 57.0% by weight of consumer cooperatives, 7.0% by weight, 5.0% by weight, dilofenac 1.0% by weight Mix the above prescription with a kneader, and stretch it on a plastic film that has been previously subjected to a peeling treatment, which is covered with a polypropylene film and pressed and transliterated > made into a thin hard bud 〇 富 直 M. 11- Styrene-isoprene-styrene segmented copolymer 15.0 wt.% (Trade name-Gary Fricus TR 1 1 11) polyisobutylene (manufactured by Exxon Chemical Co., Ltd.) 5.0 wt.% Flow ballast. * 1 23.0 wt.% Sorbitan Derivatives (Trade name: Ester H) 42 • 0% by weight 3- L- MP 1 0. 0% by weight diclofenac 5.0% by weight -2 1 This paper AA is used in China National Standards of Standards (CNS) Ya 4 threats (210X297 mm) Order-^-The Central Ministry of Economic Affairs rate of goods and workers' consumer cooperatives printed A7 __B7 _V. Description of the invention (2) Mix the above prescription with a kneader and mix Plastic film stretched on the top, covered with polypropylene iron cloth to add plaster _ »窗 施 相 I 13 plaster, thin styrene-isoprene. Diene-styrene segmented polymer (brand name-Galiveri Morse TR-1112) Flowing stone rosin ester derivative (trade name: Hula 105) 3-L-HP diclofenac aethyl ester Manufactured in accordance with the method of Example 8 and made Hard sound agent rich example 14 plaster plaster styrene-isoprene-styrene segmented polymer (trade name: Gary River Library) TR-1107) Flowing stone fiber rosin _ derivative (trade name: ester 醪 AA-6) 3-L-HP 醑 81 (ket ο pr 〇fe η) Manufactured in the same manner as in Example 9 to make a hard paste Male Example 15: Plaster styrene-isoprene-styrene segmented polymer (Trade name: Gary Fritz TR-1107) The flow stone was pre-applied to the separation area for pressure transfer, making 18. 〇 量 ％ 54.5% Hanging% 18.5wt% 6% 6.0wt% 3 3.0wt% 25.0wt96 68.0wt% 5.0wt% 1.5wt% 0.5wt% 20 .0% by weight. 43.5% by weight. 22- The paper ruler of this paper uses Chinese National Standard (CNS) Α4 size (210X297 mm) (Jing first closed the back-Note I item * page)

V. Description of the invention (21) A7 B7 Printed rosin tincture derivative (trade name: KE-311) 3-L-MP ketone tincture (ket ο pr 〇fe η) Example 16 Manufactured by the method of lfl and made into hard materials. Example 16 Plaster styrene-isoprene-styrene segmented copolymer (Trade name: Gary Fricus TR-1〗 11) Polyisobutylene (Manufactured by Yixun Chemical Co., Ltd.) Flowing stone rosin ester derivative (trade name: Capsin H > 3-L-MP ketoprofen) Manufactured in accordance with the method of Example 11 to make a hard bud β I Example 17 Plasma styrene-isoprene-styrene segmented copolymer (commercial name: Sobril 418) Polypentene flow rosin rosin ester derivative (commercial name: KE-311) 3-L- MP flurbiprofen was prepared in the same manner as in Example 12. Fenbin Example 18 Hard tone agent styrene-isoprene-styrene segmented copolymer 30. 5 weight egg% 3 .0 weight Dong% 3. 0 weight JK% 15.0 weight% 7. 0 weight% 23.0 weight: ft% 40. 0 weight% 10. 0 weight M% 5. 0 weight% 28.0 weight 5%. 0 heavy fil% 57. 7 weight] 1% 7.0 wt% 1.8 wt% weight Dong 〇.5% 21.0 wt% (please read the back side of the injection station and then fill $ item page)

C Order 2 3-This paper size is in accordance with China National Standards (CNS) A4 specifications (210X297 mm) Printed by the Central Government Bureau of the Ministry of Economic Affairs, Shellfish Consumer Cooperatives A7 _B7_ V. Description of the invention (22) (Product name : Gary Fricus TR-1107) Flowing stone rosin ester derivative (trade name: KE-311) 3-L-MP Flurbiprofen The method of Example 9 was followed to make a plaster surface. Example J Plaster styrene-isoprene-styrene segmented copolymer (trade name: Gary Fricus TR-1107) flow lycopentaspinate derivative (trade name: KE-311) 3-L -MP flurbiprofen Imitated the method of Example 10 to make a hard bud thin I. Example 20 Stiffener styrene-isoprene-styrene segmented polymer (Trade name: Gary Fricus TR-1107) Styrene-isoprene-styrene segmented polymer ( Trade name: Gary Fricus TR-1111) Flowing stone rosin ester derivative (trade name: Ester-AA- (〇3-L-MP 弗罗 tfc flurbiprofen) The manufacturing method of Example 12, Made of hard sound agent. 66.8 ft% Ί .2 heavy Dong% 4. 0% by weight 1.0 k% by weight 2 1. 0% by weight 45.0% by weight *% 2 0% by weight 9.0% by weight 5. 0% by weight 1 1.1% by weight 1 1.1% by weight 44.0% by weight ft% 6.0% by weight 7.0% rechecked% 1.0 reset% {Please read the note f on the back before filling the nest (This page) Revision-24- This paper method standard uses Chinese National Standard (CNS) A4 specification (210X297 mm) Printed by A7 _ B7 of the Central Industrial and Commercial Standards Bureau of the Ministry of Economic Affairs, Zhengong Consumer Cooperative, V. Invention Description (23) Rich Examples 21 Hard bud agent stupid ethylene-isoprene-styrene segmented copolymer (trade name: Gary Frix T β-11 0 7) mobile stone rosin derivative (trade name: 0-311) 3 -L-MP Roach Prufen The method of Example 11 yields a hard bud agent. Example 22 The hard bud agent styrene-isoprene-styrene segmented copolymer (trade name: Gary Frix TR-1111) is derived from a flowing paraffin rosin ester. (Trade name: Cool) 3-L-MP Rochprofen followed the method of Example 11 to make a plaster. Fenxi Example 23 The plaster styrene-isoprene-styrene segment Polymer (trade name: Gary Fricus TR-1112) Flowing stone rosin rosin derivative (trade name: ester 腠 H) 3-L-MP Rochipulfen imitates the method of Example 12 and makes it hard 30. Q% by weight 56.0% by weight 8.% by weight 5.0% by weight 1.0% by weight 12.0% by weight 28.0% by weight 40.0% by weight 12.0% by weight ft% 8 0% by weight 21.0% by weight 50.0% by weight 20.5% by weight 5.5% by weight 3.0% by weight (Please read the precautions on the back before filling out this page) -25- This paper size applies China National Standards (CNS) Λ4 specification (2 丨 0X297 mm) Central Bureau of Standards, Ministry of Economic Affairs; Industrial and Consumer Cooperative Cooperatives Printing A7 _B7_ V. Description of the invention (24) Fen example 24 plaster styrene-iso M-diene-styrene segmented copolymer (Trade name: Gary Fricus TR-1111) Flowing stone rosin ester derivative (Trade name: KE-311) 3-L-MP Rochp 'Lufen sodium A method similar to that of Example 9 was used to make a hard bud agent β fenfu handle 25 plaster plaster styrene-isoprene-styrene segmented copolymer (trade name: Gary Fricus TB-1107) flowing stone rosin Ester derivative (trade name: Ester Capsule) 3-L-MP Rochprofen sodium following the method of Example 10 to obtain a plaster. Fenshi Example 26 Plaster Stupid ethylene-isoprene-styrene segmented copolymer (Trade name: Gary Fricus TR-1107) Polyisobutylene (manufactured by Exxon) Flow paraffin f * Matsuba Ester derivative (trade name: Hacolin D > 3-L-MP Roch Prufen imitates the manufacturing method of Example 11 to make hard assets. -26- This paper is standardized by the Chinese national standard (CNS ) Λ4 specification (210X297 mm)% Quantity I 0% %%% Dong * Quantity «B -EΒ V3 ^ 33%%%%% Μ Quantity MV heavy%%%%%% * Quantity Heavy Γ -------- ^ ---- (Please read and read back * -Note 1 and then 1 ^ This page) Printed by A7 __B7_ Description of the invention (25) Fen Example 27 Hard bud styrene-isoprene-styrene segmented copolymer (trade name: Gary Fricus TR-1111) Flow paraffin. Pinosyl derivative (commodity Name: KE-311) 3-L-MP Kotorak followed the method of Example 9 to make a plaster. 1 Example 2S Plaster styrene-isoprene-styrene segmented copolymer (trade name) : Gary Fricus TR-1107) Flowing Stone _ Rosin ester derivative (trade name: vinegar H) 3-L-MP Kotorak followed the method of Example 11 to make a plaster. Fenxi Example 29 Hard tone agent styrene-isoprene-benzene Ethylene Segmented Copolymer (Trade name: Gary Fricus T8-1112) Flowing stone rosin ester derivative (Trade name: Ester Gum) 3-L-MP P Kotorak Tometa Fame Example 12 The production method is made into plaster. 20.0% by weight 38.0% by weight 38.0 £ «% 8.0% by weight; I% 4.0% by weight 28.0% by weight 57.5% by weight 9 0% by weight 4.5% by weight 1.0% by weight 21.1% by weight 53.0% by weight 10.0% by weight 14.0% by weight 2.0% by weight (please read the back note first) Refill the items on this page) Order-27- This paper size is in accordance with Chinese national standard (CNS > A4 size (210X297mm)) 5. Description of invention (26) A7B7

窨 例 30 Plaster styrene-isoprene-styrene segmented copolymer (trade name: Gary Fricus TR-1111) Flowing stone cypress pine pankan derivative (trade name: Liver 105 ) 3-L-MP Kotorak followed the manufacturing method of Example 11 to make a hard luxury agent. Examination Example 31 Hard bud styrene-isoprene-styrene segmented copolymer (trade name: Gary Fricus TR-1 111) Polyisobutylene (manufactured by Yixun Chemical Co., Ltd.) Flowing ballast Rosin ester derivative (trade name: KE-311) 3-L-MP Ketoprofen Follow the method of Example 8 to make a plaster.啻 Example 32 Hard tone agent styrene-isoprene-styrene segmented copolymer (trade name: Gary Fricus TR-1111)? Polyisobutylene (manufactured by Yixun Chemical Co., Ltd.) ^ Flow paraffin Rosin ester derivative (trade name: KE-311) 3-L-MP 33. 0% by weight 60. 0% by weight 5.0% Amount by weight 1.5% by weight 0.5% by weight 20.0% by weight: Κ 5.0% by weight 55.0% by weight 10.0% by weight 8.0% by weight 2.0% by weight 15.0% by weight 14.0% by weight 38.0% by weight 25.0% by weight 5 0% by weight Please note first

I Page 28- This paper size is based on the Chinese National Standard (CNS) Λ4 size (210X297 mm) A7 B7 V. Description of the invention (27) Ministry of Economic Affairs 4-Central Bureau Standard Bureau Shellfish Consumer Cooperative printed ketone m Fan (K etoprofen) 3.0% by weight According to the method of Example 9, a plaster was prepared. The solid m 33. Hard bud thin styrene-isoprene-styrene segmented copolymer 22.0% by weight (commodity Name: Gary Fricus TR- 11 11)-Polyisobutylene (manufactured by Yixun Chemical Co., Ltd.) 8 • 0% Dong Dong Flowing Stone Hungry 46.0% wt. Rosin Ester Derivative (Product Name: KE- 3 1 1) 14 • 0% by weight 3- L- MP 8 • 0% by weight Kotolak 2 • 0% by weight The method of Example 10 was used to make a hard tincture. SL 旃 例 34 _Hard bud agent styrene-isoprene-styrene segmented copolymer 15.0% by weight (trade name: Gary Fricus TR- 11 11) polyiso-butene (benefit Manufactured by Kexun Chemical Co., Ltd.> 12.0% by weight Flowing stone 72.7% by weight% Rosin ester derivative (trade name: KE- 3 1 1) 38.0% by weight 3- L- MP 4 • 0% Dong% Kotorak 4 • 0 wt. Dong% Follow the method of Example 10 to make a plaster. F W m 1 35 Hard-bonded styrene-isoprene-styrene segmented copolymer 20.0 wt. Dong% (Trade name: Gary Flickus T-11- 07) Flowing stone 45, .5 reset% -29- (Jing first "read the note f on the back side and then fill in this X) (revised paper size Free use of the Chinese National Standard (CNS) A4 (2 丨 0 > < 297 mm) V. Description of the invention (28) A7 B7 Printed pine fan_derivatives (commodities) (Name: 0-311) 3-L-MP Fulbinac is made in the same manner as in Example 10 to make a plaster. Fenchi Example 36 Hard Bud Thin 'Styrene-isoprene-styrene segmented copolymer (trade name: Gary Fricus TR-1111) polyisobutylene (produced by Yixun Chemical Co., Ltd.) flow paraffin pine derivative _ derivative (trade name : KE-311) 3-L-MP Furbinac was prepared in the same manner as in Example 12 to make a plaster. Fentium Example 37 Plaster styrene-isoprene-styrene segmented copolymer (trade name) : Gary Fricus TR-1107) Polyisobutylene (manufactured by Yixun Chemical Co., Ltd.) Flow lycoarsinone derivative (trade name: Harcolin D > 3-L-MP Fulbinaco) Preparation method of 11 to make a plaster ^ Fentium Example 38 Plaster styrene-isoprene-styrene segmented copolymer 30.5% by weight 3.0% by weight 1.0% by weight ft% 15.0% by weight % 14.0% by weight 28.0% by weight 26.0% by weight 11% 5.0% by weight 2.0% by weight% 22.2% by weight% 5.0% by weight ft% 52.0% by weight ft% 1 2. 0% by weight 7.0% by weight 2% by weight 2.0% by weight 28.0% by weight t Note on one side and then f on this page-30 This paper size is applicable to Chinese national standards (€?> 4 specifications (210 &gt); < 297 mm > 5. Description of the invention (29) A7 B7 Printed by the Consumers' Cooperative of the Central Standards Bureau of the Ministry of Economy Spufenfen imitates the method of Example 12 to make a plaster. Fenshi Example 39 Plaster styrene-isoprene-styrene segmented copolymer (Trade name: Gary Fricus TB-1111) Flowing stone rosin ester derivative (Trade name: KE-3 1 1 ) 3-L-MP Spufenfen imitates the method of Example 9 to make a hard tincture. Fenshi Example 40 Plaster styrene-isoprene-styrene segmented polymer (Trade name: Gary Fricus TR-1107) Polyisobutylene (Trade name: Pistanix) Flowing stone * Rosin ester derivative (trade name: KE-311) 3-L-MP estradiol (estradi ο 1) Following the method of Example 8, a plaster e 5 .0 wt% 5 7 0 Weight% 7.5 weight 1;% 2.0% Dong% 0.5 weight flt% 20.0 weight% 40.0 weight% 34.0 weight% 4.0 weight% 2.0 weight% 20.0 weight Egg% 5.0% by weight 45. Q% by weight 20.0% by weight 9% by weight 1.0% by weight 3 1-(Please read "Note f on the back _ before filling in this education")

This paper size is applicable to the Chinese National Standard (CNS) A4 specification (2 丨 0 > < 297 mm) I. Explanation of the invention (30) A7 B7 Example printed by Zhengong Consumer Cooperative, Central Bureau of Standards, Ministry of Economic Affairs 41 Stucco cocoon styrene-isoprene-styrene segmented copolymer (trade name: Gary Fricus TB-1111) polyisobutylene (produced by Yixun Chemical Co., Ltd.) Flow paraffin rosin derivative (commodity Name: Esters 隳 H) 3-L-MP estradiol Following the method of Example 9 to make a plaster. Example 42: Plaster styrene-isoprene-styrene segmented copolymer (commercial name: Gary Frikus TB-1111) polyisobutyl dung beetle (brand name: Pistanix >) Flown lycoxanthinate f »biological (trade name: Fulla 105) 3-LM.P Progesterone Following the method of Example 10, it is made into plaster plaster β Fen Example 43 plaster plaster stupid- Isoprene-styrene segmented copolymer f (trade name: Gary Fricus: TR-1107) '' polyisobutylene (manufactured by Exxon Chemicals Division) mobile rosin rosin ester derivative (trade name : KE-311) 20.0% by weight 12.0% by weight. 20.0% by weight * 3.0% by weight% 10.0% by weight 1.0% by weight 22.0% by weight 6.0% by weight 45%. 0% by weight 23.0% by weight 3% by weight ft% 1.0% by weight 15.0% by weight 10.0% by weight 39.0% by weight 33.0% by weight Noodles · Re-ordering note -32- This paper size is applicable to China National Standard (CNS) A4 (2 丨 0 > < 297 mm) V. Description of the invention (3i) A7 B7 Printed by the Consumers' Cooperatives of the Central Procurement Bureau, Ministry of Economic Affairs «. 3-L- MP Purgist Success (p rogesterone) was made in the same manner as in Example 11 to make a hard bud. Example 44 Plaster styrene-isoprene-styrene segmented copolymer (trade name: Gary Fricus TR-1111) Iso; Γ ene (trade name: Pistanix) flow lysin rosin ester derivative (trade name: KE-311) 3-L-MP norethisterone acetate Example 12 Example 45: Hardener styrene-isoprene-styrene segmented copolymer (trade name: Gary Flicks T-1111) Polyisobutylene (produced by Yixun Chemical Co., Ltd.) Production) Flowing stone rosin ester derivative (trade name: ester gum) 3-L-MP norethisterone The method of Example 10 was used to make a plaster. Rich Example 46 Plaster benzene Ethylene-isoprene-styrene segmented copolymer 5.0% by weight 1.0% by weight 2.0% by weight 5.0% by weight: S% 47.0% by weight 17.0% by weight Jt% 10. D reset% 1.0 heavy weight% 20.0 heavy weight% 11.0 heavy weight% 25 · 0 heavy weight% 30. 0 weight: B% 13.0 weight% 1.0 weight: K % 20. 0% by weight please first注 Λ- of Note

I Page Order% -33- This paper is free to use Chinese National Standards (CNS) VIII 4 threats (210X297 mm) V. Description of the invention (32) A7 B7 Printed by the Central Government Standards Bureau of the Ministry of Economic Affairs and printed by the Industrial and Consumer Cooperatives (trade name) : Gary Fricus TR-1112> Polyisobutylene (manufactured by Exxon Chemical Co., Ltd.) Flowing stone rosin ester derivative (trade name: Fulla 105) 3-L-MP testosterone The method of Example 9 was used to make hard lei. M tULM n. Plaster styrene-isoprene-styrene segmented copolymer (trade name: Gary Fricus TR-1107) polyisobutylene (trade name ： Pitts Knicks) Flowing stone rosin ester derivative (trade name: JUE-311) 3-L-MP Posterosterone (testosterone) The method of Example 12 was used to make a plaster. Comparative Example 6 Hard Plaster styrene-isoprene-styrene segmented copolymer (trade name: Gary Fricus T 8-U 0 7) flow stone ## polyisobutylene (trade name: Pistanix) rosin Ester derivative (brand name: ΕΕ-311) dilofenac is mixed with 逑 and mixed with a prescription, and it is extended in advance 12.0% by weight 30.0% by weight 30% 0% by weight 7.0% by weight 1.0% by weight 22.0% by weight 5.0% by weight 45.0% by weight 22.0% by weight 5 0% weight% 1.0 weight% 20.0 weight: ft% 43.5 weight% 10% 0% weight 25. 5% weight 1.0% weight% Please read the note before applying the peeling

I Side-by-side 34- Quick-use of this paper standard China National Standards (CNS) Λ4 specifications (210X297 mm) A7 B7 Printed by the Central Government Bureau of the Ministry of Economic Affairs and printed by the Industrial and Consumer Cooperatives * The upper part is covered with glycan and transliterated to make m bud m. The 3-L-MP dissolving blue of Example 9 is also used as a comparative example 6 0 1 Secondly ♦ The ointment base is thin for the soft bud. The quotient is familiar or usually read by users 1, such as graded donated fatty acid or its m type (for example, adipic acid reads myristic acid * palmitic acid * stearic acid., Oleic acid * adipic acid Price of vinegar vinegar back A 1 acid vinegar »palmitate» diethyl sebacate »hexyl laurate 9 isooctanoic acid Note 1 I 10 — I ς 醏» »» (for example »m 蠼 9 honey Wax »Dioscorea etc. 9 High-level items-. | | Grade fermentation (for example, whale wax fermentation 9 stem fat fermentation 9 whale stearase fermentation, etc.) ♦ re | α 1 I silicone oil (Eg ·· Dimethicone Academy »Tolylpolysilazane 9 ethane I Dimethylase Polysilicone Academy» Silicone Glycol Polymers, etc.) > Shuohua Argon 1 1 (eg: Hydrophilic petroleum jelly 9 White petroleum jelly refined lanolin f mobile stone 1 1 ants etc.) > Water 9 absorption promotion m (such as propylene acetate 9 diisopropyl hexadecane 1 订 order 1 diacid cool »Clautonon 9 Izo < S > etc. 9 Moisturizing m (eg glycerin 9 propylene glycol 9 succinase »sorbase, etc.) 9 spotted rash prevention 9 other 1 I additives (eg * salicylic acid» salicylic acid m methyl ester 9 leech Acid Ethanol Enzyme 9 1 1 SL-Peppermint Yeast, Camphor, Peppermint Oil, etc.) 〇1 1 Mix the above ingredients with effective ingredients 9 If necessary, Jf and stabilizers 9 Anti-gasification thin 9 Ultraviolet absorbent 9 Anti-corrosive thin 9 Anti-m 1 1 m etc. »According to this, the ointment of the present invention can be obtained. 〇- \ Second 9 One of Lei's manufacturing examples for reference Λ1 〇1 I dissolve 0.1 to 5% of the active ingredients in 1 Λ / 20 0% by weight 3 -L -MP 1 The mixture 9 at room temperature or Under humidification, mix with 0. 01 r \ y 5 wt. 1 I% UV herbicide or 0. 1 3 wt.% Anti-gasification, add 4 10 1 1 wt.% Waxes > 40 80 wt.% Addition of methane or methane or melting by heating> 1 1 I -35--I 1 1 1 This paper size is applicable to China National Standard (CNS) A4 (210X297 mm) 5. Description of the invention (34 A7 B7

And keep it at 50 ～ ιο〇 · 〇β. After the whole brewing ingredients turn into a transparent dissolving solution, use a homogenizer to mix well. Then, when the mixture is reduced to room temperature through * mixing, the ointment of the present invention can be obtained. The manufacturing examples are only one example, and the others can be manufactured by conventional or similar methods and prescriptions. In addition, there is no particular limitation on the mixing order of each mixture. Β (in ¥, various preparations, and manufacturing examples are also applicable to the above conditions) Example "fe Example 48 · Ointment Thin I White Vaseline Monostearate Glycerin Tallow Silicon Emu Oil 3-L-MP flurbiprofen 76. 0 Reset% 10. 0% by weight 10.0 Weight JK% 1. 0% by weight% 2.0% by weight 1.0% by weight Stir and mix The above ingredients are made into Fruby Profen soft bud softener file, the Ministry of Economic Affairs of the Central Ministry of Rubbing and Probationary Consumer Cooperation Du Yin «.

White petrolatum diethyl sebacate cetyl polyethene sodium lauryl ether phosphate 2-hydroxy-4-methyl benzophenone p-hydroxybenzoate 3-L-MP 7 6. 9 5 wt% 5. 0% by weight 5.0% by weight 4.0% by weight 1% by weight 01.05% by weight 2.0% by weight ketoprof en 3.0% by weight 96 The above ingredients are stirred and mixed to prepare a ketone Pu Fan soft sound. -36- This paper is in ft size, using China National Standards (CNS) M specifications (210X297 mm) L ---_----.-- i ------ 1T ------ 涞-(Please read the back of the note *. Before you buy the copy) A7 B7 Printed by the Central Government Bureau of the Ministry of Economic Affairs, WC Industrial Consumer Cooperative, 82. 95% by weight 8. 0% by weight 3.0% by weight 2.0 0.05% by weight (3.0% by weight) 3. Q% by weight 谞 is made with inomepramine ointment β as explained. Gel bases can be known or include, for example, lower alcohols (such as acetylating agents (for example: carboxyvinyl polymers, vitamins, alginic acid propylene glycol esters, etc.), diisopropanolamine, sodium oxide, etc) Sorbitol oleate, sorbitan trioleate, sorbitan monostearate, polyethylene glycol monostearate, polyoxyethylene nonylbenzene, polyoxyethylene lauryl ether, etc.) Diethyl acid, propylene glycol adipic acid f), spot rash prevention * salicylic acid, salicylic acid methyl salicylic acid ethyl peppermint oil, etc.). For each of the above bases, a gelling agent with an ultraviolet absorber can be appropriately mixed. -37- V. Description of the Invention (35) Cellar Example 50 Ointment Thin | White Vaseline Isopropyl Myristate Cetyl Wax Polyoxyethylene Lauryl Sulfate

Butyl p-hydroxybenzoate 3-L-MP Indometacin (Indometacin is mixed by mixing the above ingredients. Secondly, for the gelling agent, various commonly used bases are added to select yeast, isopropyl alcohol, etc.), water, gum Hydroxyethyl lutein, hydroxypropyl cellulose neutralizers (eg, triethanolamine, surfactants (eg, sesquiglycolic anhydride, sorbitan monooleate, sorbitan laurate, monostearyl ether, Polyethylene cetyl hydrazone recovery accelerator (eg: propyl isopropyl phosphate, clautonin, estrogen, other additives (eg, hydrazine, JI-menthol, camphor, added effective ingredients) such as It is necessary or anti-gasification agent to obtain the paper size of the present invention, using the Chinese National Standard (CNS) A4 size (210X297 mm) (please read the "$" on the back side before filling in this summer)

The central government of the Ministry of Economic Affairs has printed A7 B7 for the shellfish consumer cooperative. V. Description of the invention (36) The production examples of gel tinctures are exemplified as follows: (A) Adding gelling agent with water content below 60% by weight 0.5 ~ Swell at 5% by weight. On the one hand, (B) a mixture formed by dissolving 0.1 to 5% by weight of the active ingredient at 0.1 to 20% of 3-L-MP, and if necessary, absorbing 0.01 to 5% by weight of ultraviolet light. Or 0.01% to 3% of anti-gasification agent, dissolve with a mixture containing adioxins below 40% by weight and lower enzyme below 60% by weight, and then add (B) to (A) add a neutralizing agent, 诹Adjust the pH to 4 to 7 to obtain the gelatin of the present invention. Example 51 Gel; Carboxy vinyl polymer 2.0% by weight Hydroxypropyl cellulose 2.0% by weight Ethanol 37.0% by weight Malonase 15.0% by weight Diisopropyl adipate 2.0% by weight Diisopropanolamine 2 5% by weight 2-hydroxy-4-methoxybenzophenone 0.5% by weight 3- L-MP 3.0% by weight cetoprofen 3.0% by weight purified water 33.0% by weight Stir and mix each of the above Ingredients 诹 made with SS Pufeng gel. * Example-Example 5 2_ gelling agent carboxyvinyl polymer 1.5% by weight hydroxypropyl stilbene 2.0% by weight% ethanol 17.0% by weight 38- This paper uses Chinese National Standards (CNS > A4 specifications ( 210X297 mm) (please read "Note f on the back side before filling out this page)

Printed by A7 ____B7, Shellfish Consumer Cooperative, Central Bureau of the Ministry of Economic Affairs. 5. Description of the Invention (37) Propylene Glycol, Propylene Triethyl Enzyme 3-L-MP, Innomedacin (i.ndoietacin) The ingredients are made into solid ingredients. ”Example 5 3 Coagulant Carboxylic polymer acetic acid propylene glycol diisopropionamine (please read" Note f on the back side before filling this page ")

Q Order-Information- 3-L-MP Furnace Bip Refined Leech Mix Secondly, Propane-1, Compound, Add Accelerator, Ultraviolet Absorptive Stearase, Hydrogen Type: Flurbiprofen Combined with the above ingredients, it is made with the instructions for thin milk, which are like 2-secondary yeast, high-grade yeast, and sulphur water evenly emulsified. Its tinctures, oils, fats, etc. β, the high-grade acetogenic stearate used in the present invention, hexyldecanoate white vaseline, triclosan 30.0% by weight 10.0% by weight 0.2% by weight 3 .0 Reset% 1. 0 Childhood% 35.3% by weight Innomethacin Condensate »1.0% by weight 35.0% by weight 10.0.0% by weight 3.0% by weight 3.0% by weight ft % 1.0 Heavy wing:% 49. 0% by weight. It has Fruby-Profen condensate. The medicinal ingredient, 3-L-formaldehyde gasified argon, emulsified thinly, can be mixed with the desired one. Acid absorption, neutralization, antiseptic, t fermentation, including whale fermentation, octyldodecane fermentation, sulphur, mobile stone, etc., as for milk-39- This paper is in accordance with Chinese national standard (CNS) A4 specification (210X297 mm) A7 ___B7 _ V. Description of the invention (38) The suspected users are polyalkylene glycol ethers, sorbitan fatty acid esters, and polygas ethylene sorbitan fatty acids Ester, Polyvinyl Ethylene Alkyl Phenyl Ethers, etc., Lauryl Ether, Cetyl Ether, Stearyl Ether, Yushen Ether, etc. are the best The amount is 5 to 15% by weight of high-grade yeasts, 10 to 20% by weight of Tungsten hydrochloride, and 1 to 3% of% by weight emulsified cocoons. It is suitable, and the preservative seems to add 0.1 to 0.5% by weight. Second, 僳 uses propylene acetate, diethyl decanoate, diisopropyl adipate, etc. as absorption enhancers β. As for the preservatives including glycerol, malonate, sorbic acid, etc. 0.5 to 5% by weight can fully expect its effect. In addition, a gel-like milk having an intermediate property between an emulsion and a gel was prepared. The above-mentioned milk was mixed with a carboxyvinyl polymer, hydroxyethylandrosin, ricyldividin, ethyldividin, carboxylate Methyl cellulose and other compounds are used as cypress, and diisopropanolamine, triethylenylamine, and argon oxidation pin are used as the neutralization two, and the pH is adjusted to 4 ~ 8, preferably 5 ~ 6.5 , And can broadcast the gel-like emulsion of the present invention. The following example represents a manufacturing example of a condensed milk shovel.

(A > The resulting mixture is dissolved by 0.1 to 5% by weight of the medicinal ingredient at 0.1 to 20% by weight of 3-L-HP, and if necessary, it is dissolved by 0.01 ... 5% by weight of an ultraviolet absorber, or D. if necessary. ～ 3 重 夤 #Antioxidant susceptible to dissolve It is a mixture of higher fatty acid esters of less than 25 weights and 96 and lower enzymes of less than 40 weight%, and added 0.5% by weight of preservatives and emulsifiers. (B) Add 0.5 ~ 5 weight X coagulant to swell in water, then add (B) to (A) and emulsify with homogenizer, emulsify -40- This paper is mixed with Chinese national standard (CNS) A4 specification (2 丨 0X297mm)-((Please read the notes on the back before filling in this page *) Printed by the Ministry of Economic Affairs, Central Liangshou Bureau, Consumer Cooperative, A7 B7 5. Printed by the consumer cooperative. 5. Description of the invention (39) After adding a neutralizing agent, and adjusting the pH value to 4 ~ 8, you can obtain the condensed warm milk of the present invention. Fat egg% Middle bond fat. Fatty acid triglyceride 5 '0 鲎 *% Monostearate polyethylene glycolase 3.0 Fat egg% glycerol yeast 5.0% by weight Ethylene polymer 1.0 wt% diisopropanolamine 0.4 wt% methyl parahydroxybenzoate 0.2 wt% indonetacin 1.0 wt% 3-L-Μ P 5 0 weight *% refined water residues are stirred and mixed with the above ingredients to prepare an Innomethacin emulsion. Fenzhili 55 Dairy maker (Medium Fatty Acid Triglyceride _ 3.0 weight most% glycerin 10. 0% by weight of carboxyvinyl polymer 1.0% by weight of dimethylpropionate reset by 0.4% 3-L-MP t 5.0% by weight ％% Frubyprofen (f 1 urbi ρ r 〇fe η ) 1. 0% by weight of the purified water residue is stirred and mixed with the above ingredients to prepare a frobiprofen cream. Sale application. Example 5 6 Emulsion-41- This paper size is applicable to the Chinese national standard (CNS > A4) Specifications (210X297 mm) A7 B7 V. Description of the invention (40) The printing of whale yeast 3 by the Central Standards Bureau of the Ministry of Economic Affairs, Zhengong Consumer Cooperative, 3 • 0% of the scene% of stearyl alcohol 3.0% by weight of polyvinyl ether 2 • 0 weight *% (Nicole BC-20Τί:, Β manufactured by Photochemical Co., Ltd. ) White petroleum jelly 16.0.0% by volume Flow paraffin * 2 • 0 weight Jt% paraben benzoate 0.2 weight% 3- L- MP 2.0 weight weight%% Fan (K et 〇Ε, r 〇 丨 fe η) 2.0% by weight of purified water 69 • θ% by weight The above ingredients are stirred and mixed to prepare m Pufan cream 〇cyanate 5 7 Milk acetostearyl alcohol 7 • 0% by weight (N AA -48, manufactured by Japan Oil & Fat Co., Ltd.) Polyethylene laurate glycerol m ether 2 • 5% by weight (manufactured by Nikol BL-25 > Β Photochemical Co., Ltd.) White Fantulin 10. 0% by weight% flow Paraffin 5 '.0% by weight p-methyl benzoate 0.2% by weight 3- L- MP 3. 0% by weight ketone m Fan (ket op Γ 0 fe η) 〆 3.0% by weight purified water 69 _ .3% by weight m Each ingredient is made to contain 醑 Pufan milk sound «* W 旃 例 5 8 乳 乳 -42- ii—id— (please read the precautions on the back and then write this page) Standard (CNS M4 (21 × 297 mm) Printed by the Central Government Bureau of the Ministry of Economic Affairs, printed by the Shellfish Consumer Cooperative A7 B7 V. Description of the invention (41) Whale leaven 4 • 0% by weight Stearin leaven 4 • 0 weight % Polyethylene whale m ferment 2 • 0 weight Μ% white petrolatum 14. 0 child% mobile lithules 2.0 child%% methylparaben 0.2 weight *% 3- L- MP 2.0 Weight ft% Kotorak 3 • 0% by weight purified water 67.8% by weight m Mix and mix the above ingredients to prepare Kotorak milk to sell β s_ m Example 5 9 Emulsion whale m leaven 4 • 0 wt% stearin Fermentation 4.0% by weight% Polyoxyethylene cetyl ether 2.0% by weight White petroleum jelly 12.0% by weight Flow paraffin 3 0% by weight parabens m 0 • 2% by weight 3- L- MP 4 • 0% by weight G 3 • billion children weight% purified water # 6 5.8% by weight or more ingredients mixed with stirring, a cream containing Ke Lan ίε la. Fen Li FiO Emulsion Whale Yeast 3. Q% by weight Stearyl Alcohol 4.0% by weight -4 3-This paper size is based on Chinese national standards (CNS > A4 size (210X297mm) (please first "Read the back _ of the note 项-item deposit to complete this page)

A7 B7 V. Description of the invention (42) Polyethylene vinyl ether (Nicole B0-20, white petroleum jelly made from Nikko Chemical Co., Ltd., white petroleum jelly, para-hydroxybenzoic acid methyl ester 2.0% by weight, 1.0% by weight ft% 6 0% Li% 0.2% Tongren% Printed by the Central Ministry of Economic Affairs Bureau of the Ministry of Economic Affairs and Consumer Cooperatives to print 3-L-Μ P. Ketoprofen refined water mixing and mixing the above ingredients Fen (II emulsion B Fermented stearyl alcohol (NAA-48 p, this oil company's poly (ethylene vinyl cetyl ether), white petrolatum mobile stone, p-hydroxybenzoic acid methyl 3-L-MP _ ketoprofen, purified water, mixing and mixing the above ingredients next Herein, the reserve-type attachment agent is a gel base, a gel base made from 3-L-MP, acetone, or a stone gangue 3.0 wt% 1.0 wt% 70. 8 5% by weight is prepared to contain ketopufan cream. 5.0% by weight is produced by 2.0% by weight% by 1.0% by weight is 4.0% by weight is 0.2% by weight 8.0% by weight 3.0% by weight 67 8% 畺% 诹 is made with _ Pu $ cream cream β appendix in detail. The _ Ming reserves of the type of patch diol, lower alcohol, water and water-soluble high content or by fatty fermentation and more Produced by alcohols, formed by silicone-based gel bases -44- (Please read the note on the back before filling in this I)

The size of this paper is in accordance with China National Standards (CNS) A4 (210X297 mm). Printed by the Consumer Cooperatives of the Central Liangsong Bureau of the Ministry of Economic Affairs. A7 B7. 5. Description of the invention. W. Its medicinal rain component is a sheet of germanium amount type sticker. It should contain 10 ~ 100 «g. If the content is less than 10 · β, the analgesic effect of mineral retention cannot be obtained, but if it exceeds 1 ODlg Due to the possibility of causing obstacles to the digestive tract and the skin, it is not appropriate to use it. The remaining type of the present invention is affixed to the active ingredient through the skin. Thin (reservoir to make the 1st 逋 administering device for the surface of the skin) First, according to the medicine thin, it is necessary to obtain skin permeability through effective ingredients of a therapeutically effective amount, Among them, it is best to have little irritation to the skin and have excellent safety, and it is better that it does not cause actual chemical changes during storage. In addition to the second effective ingredient, the drug tank can be used in accordance with its needs. Transdermal absorption is mixed in the base ingredients to promote thinning, sleepiness, sterilization, and gasification prevention, UV absorbers, fillers, tackifiers, emulsifiers, emulsifiers, creases, and other conventional additives such as reducing skin irritants, anti-corrosive thin moisturizers, water, and solubilizing agents are used as external agents. Regarding the percutaneous absorption enhancer, the rate of penetration of the active ingredients of the skin, such as the local effect of the active ingredients, can be set to a speed of 30 ~ 3QQ # g / hr, such as the systemic therapeutic effect When the speed is set to 150 ~ 2500 # g / hre, if the transmission speed is not 30, the full φ effect cannot be obtained at ug / hr, but if it exceeds 2 50 0 // g / hr However, it is not suitable for use because it may cause side effects such as dark skin or digestive tract. Transdermal absorption can be promoted by using the known acetic enzyme, oleic acid, 1-dodecylazepine-2-one, JI- Peppermint ferment, d-limonene. It is best to mix with thinner and thinner. Mix the viscosity of the agent at -4 5-This paper size is applicable to China Standards (CNS) A4 (210X297 mm) (Please First read the note $ on the back and then fill out this page.) Order the printed version of the Shellfish Consumer Cooperative in the Ministry of Economic Affairs A7 B7 V. Description of the invention (44) 5 0 0 ~ 2 00 00 cps of the standard sugar. If the viscosity of the medicine is less than 500 cps 畤, when the adhesive is applied to the skin of the skin, the tincture is easy to come out of the thin storage tank and it is not suitable to apply. When the viscosity of the drug exceeds 2000 CPS, it is difficult to obtain the permeability of the skin of the drug Ning. The thinning and even the thickening rain, mixing the soluble polymer in the drug cocoon strip. For example, alginic acid, carboxymethazine, Ji Suna, Han Tian, Ming Zhi, hydroxypropyl Jivin, polyacrylic acid, polyacrylic acid pin, polyvinyl ferment, polyvinylpyrrolidone, methylmethyvin, methylvinyl ether-horse For anhydride copolymers, etc. / As for the pH adjustment, it is best to mix the pH range of the drug bar to 3 ~ 8. If the pH of the drug strip is lower than 3, it will cause irritation to the skin, and it is not suitable to use it. If the pH is higher than 8, it is not suitable to be attached to the skin due to its sexual nature. The permeability of the peptone is also poor. The pH adjusting agent can use the conventional citrate-like acid, osmic acid, sodium phosphate, etc. "to make the base formulation of the pharmaceutical tank. One of the implementation modes includes glycols, lower enzymes. , Water and water-soluble polymers are formed by a thin base. Among them, the adipic enzymes have a numbing effect on skin anxiety. In addition to alleviating the general irritability of the skin to the skin, it can also increase the dissolved concentration of the active ingredient in the tincture, which can be recovered from time to time. It has the effect of improving the permeability of the skin of medicinal herbs. ”In the case of betaine, it is suitable to use betaine, such as lyase, malonate, succinate, polyethylenease, and polypropylenease. The mixing amount is preferably between 5 and 9D% by weight. If it is less than 5%, it will not be suitable for use on the skin, but if it exceeds 90% by weight, it will not be suitable for use when the penetration of the skin is poor. Lower alcohol, the main one is for the purpose of improving the transdermal recovery of the main agent-4 6-This paper size is applicable to China National Standard (CNS) A4 (210X297 mm) (Please read the note f on the back first) Please fill in this page again) Order A7 B7 Printed by the Central Laboratories Bureau of the Ministry of Economic Affairs of the Consumers' Cooperatives Co., Ltd. 5. Description of Invention (43). Examples of low-grade yeast, including ethyl acetate, propionate, butanase, allylase , Self-fermentation, etc. The mixing amount of low-level yeast should preferably be within the range of 5 to 50% by weight. "If it is less than 5% by weight, the permeation of the skin can not be obtained." At 昙%, it is not suitable to use __ because it causes thorns on the skin. Water-soluble polymers can reduce the viscosity of the thin film and prevent the thin film from leaking when applied to the skin. "The praised water-soluble polymer indicates a polymer that can be dissolved in the medicament strip in this state." The conventional polymer can be used as an external agent, and alginic acid, carboxymethyl androsterin, agar, and absurdity can be applied. , Hydroxypropyl metamer, polyacrylic acid, polyacrylic acid pin, polyvinyl ferment, polyvinylpyrrolidone, methyl Vitamins, methyl vinyl ether-maleic anhydride copolymer-Long in this embodiment, the adjustment method of 剤, for example, (a) the water-soluble polymer can be swollen with water, (b) the active ingredient can be dissolved with 3-LP-MP Secondly, it is obtained by adding (M to (a) to change the pH value to sexuality.) As a base for tincture storage tanks, another embodiment includes an enzyme containing an aliphatic enzyme and Polyether alcohols »β Aliphatic fermentation, including lauryl fermentation, myristyl alcohol, dow wax fermentation, stearic fermentation, isostearyl alcohol, aralkyl fermentation, oleyl alcohol and others Compared with lauryl-based yeast, the smaller number of fatty yeasts is not suitable because it is more susceptible to Kuyong. On the other hand, fatty yeasts with larger atomic numbers are produced in pharmaceuticals than aralkyl-based yeasts. It is best to use β-aliphatic fermentation mixtures that are too lumpy like 10 to 50% by weight. If it is less than 10% by weight, the drug is thin (the liquidity is high, when paste Remarks on the skin please re-book 1 I d order 4 7- This paper size is free to use China National Standard (CNS) A4 specification (210X297 mm) Economy Printed by the Central Labor Bureau, Shellfish Consumer Cooperatives «. A7 _ B7______ V. Description of the Invention (46) Time, the drug in" System 1 "is out of the scope of application. When it is more than 50 weight 5, it is on the skin The thorny nature of the prisoner becomes high and it is not suitable for use. "The multi-fermentation malonate, succinate, polyglycol, polymalonate, glycerol, polytriol, etc. are quite irritating to the skin. It should be used. ， The amount of deer fermentation is preferably like the range between 25 ~ 60% by weight. If it is less than 25% by weight, the release of the effective ingredients due to the small fluidity of the drug is "Unfavorable" If it is higher than 60% by weight, on the contrary, due to the high fluidity, there will be leakage of the drug. According to the sample curtain of this implementation, olive oil can be mixed if necessary. • Brazil Palm oil, hardened oil, flax oil, soybean oil, castor oil, lanolin, oils such as flow stone, petroleum jelly, diisopropyl adipate, isopropyl palmitate isopropyl palmitate, or Fatty acid esters such as glycerol-oleate, glycerol-myristate, and glycerol-laurate.鼷 In this embodiment, the method of adjusting the medicament is, for example, adding aliphatic yeast and polyzyme to the medicinal ingredients and heating and dissolving at 6 ° C. Then, slowly stir and apply cooling to obtain the trimming. Furthermore, it becomes Another embodiment of the base of the medicine storage tank, including a thin coagulum base containing scopolamines and silicones. The scopolamines, based on the consideration of the safety of gold, use mobile scopolamine (pharmaceutical formula), and flow polyisobutylene. , Thirty sulfane, petroleum jelly (_ Xuefang, cosmetic base 0 thin), etc. are most applicable. Silicones, although there are no special restrictions ^, but polydimethylsilane is the best in terms of safety. In terms of the mixing ratio of this embodiment, it can be adjusted by the ratio of soft palate components such as petroleum jelly or dimethylsilane to other liquid components. CNS > A4 size (210X297mm) (Please read the notes on the back before filling this page) Order printed by the Central Ministry of Economic Affairs and the Junfangzhengong Cooperative Consumer Cooperative Association A7 Β7 V. Description of the invention (47) m viscosity ·》 Best case of soft palate component and liquid component is better than 5 : 1 to 2: 3 m in this example m _ the method of reorganization »For example, the medicinal ingredient is dissolved in 3-L-MP by heating and dissolved in t * Simultaneously add and mix the soft palate ingredients to adjust it. Rich Illustrative ILL · Storage Type Adhesives * 1) Lining material layer polyester strip film. 2) The tincture tank layer is sealed with 4 g of the composition shown below. Torac 5 parts 3-L-MP 3 parts carboxyvinyl polymer 2 parts malonase 30 parts triethyl citrate 19 parts purified water 39.4 parts 2-hydroxy-4-methoxybenzobenzo_ 0. 5 parts of diisopropionate 1 • 1 part of 100 wt ft% Swelled with 23 parts of purified water 1 part of carboxyvinyl polymer mixed with 30 parts of malonase and 20 parts of citrate ZT ethyl ester »5 Kotorac »5 parts of 3-L-MP and 0.5 parts of 2-hydroxy-4-methylbenzophenone solution f, and then stirred, followed by the addition of 16.4 parts of purified 'water dissolve 1.1 parts of two The solution produced by isopromamine is stirred until the whole is formed into a homogeneous liquid to obtain a gelling agent. 3) The drug thin layer I material layer is released. Durajota-49- This paper is based on China National Standards (CNS) ) Α4 size (210X297 mm) (Please read the note on the back before writing this page)

A7 __B7_ V. Description of the invention (48) 4) Acrylic strip adhesive (戚 peripheral part of the support) of the pressure-pressing agent layer is composed of 1) ~ 4), which is a storage-type attachment thin film (__ is formed by peeling internally) The release surface and the surrounding pressure-sensitive adhesive surface were made into external deposits. Example 63 Storage-type adhesive patch. 1) Lining material layer polyester film 2) Medicine thin I storage tank sealed with 4 g of the same example Composition of 62. 3) The drug layer and the material layer are all durah. 4) The silicone adhesive is composed of 1) ~ 4). It is a reserve type adhesive. It has a peeling lining on the surface of the adhesive to form an outer layer. Product β Fen Example 64 Storage-type adhering agent 1) Lining material layer polyester strip film 2) The elixir tank layer is sealed with 4 g of oily gel composition ketone (U et oprofen) as shown below 3 parts flowing paraffin 70 Parts stearyl ferment 20 parts d-citrate mene 2 parts 3-L- MP 5 parts 100% by weight 3) release agent material 靥 codella f 4) pressure-sensitive adhesive layer SI S strip adhesive (Peripheral support body) Printed by the Ministry of Economic Affairs of the Ministry of Economic Affairs of the Kazunori Bureau Shellfish Consumer Cooperative (please read the precautions on the back before filling out this page) 1) to 4) constitute a reserve-type patch and release it on the drug The surface and the pressure-sensitive adhesive surface have a release layer as an outer layer. Fenju Example 65 Storage type adhesive-50-This paper uses Chinese National Standard (CNS) Λ4 specification (210X297 mm) A7 _B7 _ V. Description of the invention (49) 1) Lining material layer polyester strip Film 2) 4 g of the composition of Example 64 was sealed in the drug tank layer 3) Caudran 4 was released as the elixir material layer 4) Polyisobutylene strip adhesive on the pressure-sensitive adhesive layer was composed of 1) ~ 4 > The adhesive has a release layer on the surface of the pressure-sensitive adhesive to form an outer layer. Window Example 66 Storage Type Adhesive 1) Lining material employed Aluminum laminated polyester strip film. 2) The tincture tank layer is sealed with 4 g of the following gel composition. Indooaetacin 5 parts silicone 80 parts glycerol monolaurate 5 parts 3-L-HP 10 parts Layers of Corderland 4) Sensitive adhesive layer silicone stripe adhesive (peripheral part of the holder) It consists of 1) to 4) and is a storage type adhesive. The pressure-sensitive adhesive layer has a release layer as an outer layer. Accumulation. Example 67 Storage-type adhesive agent 1) Linpo material layer, aluminum laminated polyester film, printed by the Central Government Bureau of the Ministry of Economic Affairs, printed by Shelley Consumer Cooperative (please read the note on the back before changing the nest page) 2 & gt 4 g of the coagulation composition of Example 66 was sealed in the thin tank layer. Diclofenac sodium 5 parts Silicic acid 80 parts Glycerol monolaurate 5 parts JI-Peppermint leave 5 parts-51- This paper size is suitable for China National Standards (CNS) A4 (210X297 mm) I A7 B7 V. Description of the invention (50) 5 copies of 100% by weight printed by the Shellfish Consumer Cooperative of the Central Bureau of Standards, Lithium Ministry of Lithium 3) Release __ material layer of Caudran 4) Qi Wuxing, followed by a layer of silicone adhesive 1) ~ 4) Form a shovel-type adhesive agent. In the case of pressure contact, the tooth has a peeling layer to form an external object. 啻 抡 68 68 reserve type adhesive thin 1) Lining material layer aluminum aluminum layer polyester A thin film of 2 g liniment tank layer was sealed 4 g as shown below. Yubuxiong Luoer Hydrochloric Acid (t u 1 obut er ο 1 hydroch 1 or ide) 5 servings 3

MP side-, note

2I page

Stearyl Alcohol Cetyl Alcohol Mountain ¥ Fermented Propylene Glycol 1,3-Butanedihydrolaurate 3-L-MP 10 parts 10 parts 10 parts 20 parts 35 parts 5 parts 5 parts 100 Reset% 3 > Release agent material layer Cowderland 4) Pressure-sensitive adhesive layer silicon adhesive (supports the edge of the spinal cord) »U ~ constitutes a storage-type adhesive, and has a release layer in the drug release layer and the warm adhesive layer. The outer layer 〇 Secondly, the cleaning agent will be described in detail. The cleaning agent of the present invention must be mixed with 10 to 70% by weight of ethanol, propanol, isopropanol and other monoalcohols, polyethylene glycol, malonase-52- 本 纸 St Standard Di uses the Chinese National Standard (CNS) M specifications (210X297 mm) A7 B7 V. Description of invention (5 labors) Printed by the Central Labor Bureau of the Ministry of Economic Affairs, Shellfish Consumer Cooperatives 9 Multi-fermentation enzymes such as succinic acid and fermented yeast Class 9 55 wt% or less water, 60 wt% or less adipic acid * Sebacic acid myristic acid and other fatty acids, add 0.5-5 ~ 10 wt% medicinal ingredients, 0 丨. 5 ί ~ 2fl 丨Tung% 3- • L-MP, if necessary, can be remixed with 0. fl 1 ~ 5 wt% UV absorber The obtained rubbing _ 〇 According to the above prescriptions and manufacturing methods obtained from the conventional manufacturing method of the rubbing agent can be obtained according to the present invention. If necessary, you can mix the neutralizing agent or methyl m-dimension required to adjust the pH, carboxyvinyl polymer, hydroxypropyl cellulose, and other viscosity imparting agents »spotting agent». Or other additives (For example; Salicylic Acid > Methyl Salicylate, Ethyl Salicylic Acid 9 Lithium-menthol, Camphor > Peppermint Oil »Capsule Oil * Vanillyl Enzyme Nonanoic Acid 9 Thymol • Crutamine Dayton 9 Yixun < B > > Propylene sulfonate adipic acid, etc.) Cao. Example 69 Etchant 4 5 • 0% by weight 2-hydroxy-4 -methylbenzobenzophenone 0 .6% by weight of diisopropyl adipate 30.0% by weight of hydrazone-tocopherol 1.0 reset% hydroxypropyl m vitamine 15% by weight of 3-% L-MP 4.0% by weight of ketone m where (ket op r 〇fe η) # 2.0% by weight of purified water i '15.9% by weight The above ingredients are mixed by mixing to prepare mm All wipes 0 * _ 1 Example 70 Cleaner propylene glycol 10.0% by weight -53- (Please read the "Cautions on the back before filling this page") This paper uses the Chinese National Standard (CNS) Λ4 specification (210X297 (Mm) A7 B7 V. Description of the invention (52) 2-Hydroxy-4-methanhydrin phenol 0.2 weight JI% monolaurate polyethylene glycol -10. 0 weight% Crutamin collar 0.5 Volume% Propion m 18 • 0 Gravity% Alcohol 20 0 Tung *%. Ethyl Fermentation • 28.8 μm% 3- L- MP 2.0% Volume% Ketoprofen 0.5% by weight Refined water 10. 0% by weight Taiwan mixed with the above ingredients to prepare _ 鞴 Fan rubbing 剤 71 Example 71. Wipes polyethylene glycol 4 00 10. 0% by weight 2-hydroxy-4 -methylbenzophenone 0 .5% by weight Ύ-tocopherol 1.0% by weight isopropion 31.5% by weight acetic acid 40.0 reset% 3- L-MP 7.0% by weight Kotolac 5.0% by weight sugar water 5.0% by weight (please read the note on the back before filling in this page) Printed by the Local Consumer Cooperative, stir the above ingredients to prepare Kotorac Brightener * * 例 72 Emulsion Monolaurate Polyoxalase 2,2-Dihydroxy-4-methylbenzobenzyl adipate Diisopropyl 5 4-This paper is based on the Chinese National Standard (CNS> A4 specification (210X297 mm) U. 0% by weight 〇. 7% by weight% 4 · 0% by weight A7 ___B7_ 5. Description of the invention ( 53) 3-Acetylated Benzene Modified Alcohol 49.6% by weight 3-L-MP 5.0% by weight (please read the "$" on the back side before filling out this page) ____- · Kotorak 3.0% by weight «Mix the above ingredients and make them with Kotorak rub_〇Second 躭" "Mist thin detailed description of the spray of the present invention _ you seven medicinal ingredients dissolved in 3-L-MP, acetic acid, isopropyl The solution formed by low-level yeast and other yeasts is added with water and vulgar gas, dimethyl ether, liquefied petroleum gas and other sprays or ethylene glycol such as malonase, butanediol, polyethylene glycol, etc. If necessary, it can be mixed with excipients such as betulin, peppermint oil, diphenyl zymotamine, etc., or talc, anti-chemical agents, anti-ultraviolet absorption Wait. g_jfe Example 丄 s mmm Dissolve 3 parts of fcetoprofen in 5 parts of 3-L-MP, then mix with 4 parts of birch brain and 3 parts of acetic acid, add 2 6 parts of water to the mixed solution and charge In a gas-soluble concrete container, add 4 parts of talc concrete solution, press and enter a mixture of 13 parts of dimethyl ether and 12 parts of liquefied petroleum gas as a spray, and install a 0.6 ·· tube with a pore size of 0.4 ηη sludge. The 0.4m diameter low-bolt pipe fittings are secondly equipped with a mechanical stop button to obtain anti-inflammatory and analgesic thin air-soluble 醪 涮 · > Printed by the Ministry of Economic Affairs Central Liangsong Bureau Off-line Consumer Cooperative, which can be mixed, and mixed Fermented water class two makeup enzymes propylated two, .. ,, yiyouming or ganfa \, this and alcohol. Water-grade, low-grade alcohol and other detailed alcohols _ low B. Water, using makeup NP can alcoholize L-, two pairs of 3 ethyl acetate and agent ester secondary acid. Description: Its effect is on the single-sided oil-based paper size, which is in accordance with the Chinese National Standard (CNS) Λ4 specification (210X297 mm). Printed by the WC Industrial Consumer Cooperatives of the Central Bureau of Standards of the Ministry of Economic Affairs «A7 _B7_ V. Description of the invention ( 54) In addition, if it is necessary, it can be combined with stearic acid, such as shovel, borax, alum, zinc sulfate, sulfonium or light, anti-gasification agent, anticorrosive thinner I, neutralizer, etc. β vm Μ74 Lotion thin acetonitrile refined water propylene glycol 3-L-MP keto pufan (ket 〇pr 〇fe η) 57. 〇k egg% 34.0% by weight 5.0% by weight% 3.0% by weight% I. 0% 蓦% Stir and mix the above ingredients to prepare a ketone containing lotion Example 75 Lotion 剤 Ethanol Refined Water Propylene Glycol 3-L-MP Innodacin (ind 〇betaci η) Stir and mix the above ingredients to prepare Indomethacin lotion g Example 76 Toner lotion ethanol refined water propylene glycol methylcellulose 3-L-MP flurbiprofen 5 6- This paper is a standard Chinese standard (CNS) Α4 specification (210X297 mm) (Please read the precautions on the back before filling in this ) 38.0% by weight 50.0% by weight 6.0% by weight 5 G% by weight 1.0% by weight 38.0% by weight 50% 0 Reset% 6.0% by weight 0.8% 7% by weight 0% by weight 2.0% by weight Prescription,-V. Description of the invention (55) A7B7 Printed by the Central Bureau of Standards of the Ministry of Economic Affairs, Shellfish Consumer Cooperatives, mixed with the above ingredients to prepare a lotion containing Fröbiprofen_ » Secondly, it is explained that the thin bag is thin, and the thin bag of the present invention uses 3-L-MP as the dissolving agent of the active ingredient of the fat-soluble powder. Among them are fat-soluble powder, which means powder that is insoluble or hardly soluble in water. There are B! Active ingredients used in the bag I », although all kinds of added cocoons can be used, it is best to use licorice root and licorice. Acid stearate, glycyrrhizic acid, L-ascorbic acid stearate, L-ascorbic acid palmitate, 0-phenol, «osteochemical, biotin, isophenylmethylphenol, etc. β These soluble powders pseudo-L-MP as a dissolving agent can be stably dissolved in the base and can form a kind of bag which has no mystery and has a good cooling effect. The content of 3-L-MP in the bag is preferably in the range of 0.001 to 5% by weight. If it is less than 0.001% by weight, the effect of the dissolving agent cannot be fully exerted, and when it exceeds 5% by weight, it is quite It is difficult to obtain a filler having good physical properties and usability. This bagging agent is not particularly limited as long as it is a conventionally known dosage form, including face washing (milky, silt, foamy) bags, sheet (拈 箸 thin | type, impregnated) bags, exfoliated forms (Forming a film type) Of course, β, such as bags, are of course mixed with the conventionally known "fillings, pancakes, etc., without any restrictions β. Practice-Example 77 Milky bagged vocal» Flow paraffin 10.0% by weight cetyl alcohol 1 0% by weight Sorbitol Anhydride Army Stearate 3.0% by weight POE (20) Sorbitan Anhydride Monostearate 3.0 Reset% -57- This paper size applies to two Chinese standards (CNS) Α4 (210X297 mm) Please note first.

I order A7 B7

V. Description of the invention (56) 1,3-butanediol glycerol p-hydroxybenylate methyl glycyrrhizin stearate 3-.L-MP refined water stirred cellar 5.0% by weight 3.0% by weight egg 0 2% egg% 0.1% weight 1.0 S egg% 73.7% weight Please make M • St- injection of kaolin talc glycerin glyceryl dicarboxymethane POE made of hydroxy L-mixed ingredients Example of milky bagging agent 78 Powdery soil bagging agent Soil alcohol cellulose (20) Sorbitol anhydride monooleate methyl benzoate soil blood acid stearate

3-L-MP 20.0% by weight 8% by weight ft% 3.0% by weight 3.0% by weight 0.3% by weight 2.0% by weight 0.1% by weight 0.2% ft% 3.0 weight%

I Page Order Printed and purified water from the Central Ministry of Economic Affairs, the Central Working Group of the Jeonggong Consumer Cooperative, 60. 4% by weight, mixing the above ingredients to prepare a powdered bag. G mm 7 9 foam bag. F »stearin Acid 5.0% by weight Dongshan Mountain acid 5.0% by weight cetyl alcohol 1.0% by weight 30 sessane 4.0% by weight -58- This paper size is applicable to Chinese impoverished family members (CNS) Λ4 specifications ( 210X297 mm) V. Description of the invention (57) Glycerin 1 5 · 0 Heavy manganese ％ ΡOE (4 0) Monostearate 1.0% by weight ethyl parahydroxybenzoate 0.1% by weight L-Ascorbic acid palmitic acid m 0.05 wt% 3- L-MP 0 · 5 a egg% refined water • 68.35 wt% Stir and mix the above ingredients, prepare the original solution, and simultaneously fill with liquefied petroleum gas to make a foamed bagging agent 〇W 旃Example 30 Adhesive sheet-like bagging agent gelatin 8. 0% by weight% glycerin 25.0% by weight sorbitol 7. 0% by weight sodium polyacrylate 2.0% by weight aluminum hydroxide 2. fl weight Amount% methyl parahydroxybenzoate 1.0% by weight isopropyl phenol 0.01% by weight 3- L-MP 0 · 0 0 5% by weight purified water 54 · 9 3 5% by weight Central Ministry of Economic Affairs The local shellfish consumer cooperation du printed the cover with a cover bag, the surface after the film is sticky, and the cloth is made of 'no 0', the shape is stretched, and the points are set to cut into as Fit and mix the film and stir. Example: Fen oil and saccharine-packed flakes impregnated with dibutyl alcohol %% of the amount of eggs 3 This paper size is applicable to China National Standards (CNS > M size (210X297 mm)) Printed by the consumer cooperative A7 B7 Amendment 6 Supplement * V. Description of the invention (58) Hyaluronic acid sales 0.1% by weight methyl parahydroxybenzoate 0.1 weight egg% glycyrrhizic acid 0.1 weight% 3-L -MP 0. 0 5 wt% purified water 7 ». 74 children's amount%. Mix and mix the above ingredients, impregnated with non-miscellaneous cloth, g is set with a release film. Cut into a predetermined shape to prepare an impregnated sheet Packing agent in the shape of a bag. Ying Lili 82 Scooping castrate polyvinyl alcohol 20 · 0% by weight Carboxymethyl ferricin 3.0% by weight Child gasification titanium 8. 0% by weight 5.0% by weight Triacontane 3.0% by weight POE (10) Nonylphenyl ether 0.5 Reset% methyl parahydroxybenzoate 0.1% by weight Calcified phenol 0.0% Reset 3- L-MP 0.1% by weight purified water 60.29% by weight Search and mix the above ingredients to prepare a peelable bagging agent. Th Comparative Example 7 Milky bagging agent Except that 3-L-MP was not mixed, the same mixing and cracking method as in Example 41 was used to prepare a milky pouch. Fch Comparative Example 8 A viscous pouch type sachet was not mixed with 3-L-MP Except for the same mixing and preparation method as Example 80-60 (please read the precautions on the back before filling this page) This paper size is in accordance with China National Standards (CNS) A4 specifications (210X297 mm) A7 B7 5 Explanation of the invention (59) It is made into an adhesive-shaped Η-shaped bag. Test 1 Li 1 The plaster of Example 7 and the hard bud preparations of Comparative Examples 4 to 5 were stored at 5 eC for 2 weeks and observed over time. Crystallization of medicinal ingredients. Results are shown in Table 1. Table 1

Sample item: 1 day, 3 days, 7 days, 14 days. Example 7: Plaster: 20000; Comparative Example: 4: Hard Bud; XXXXX; Comparative Example: 5: Plaster: XXXXXX: No crystallization observed; X: Crystallized by observation. From the above results, it can be understood that Comparative Example 4 without the addition of a dissolving agent, and Comparative Example 5 using nutmeg and isopropyl ester in the base agent will produce Clooney New Economy Ministry's Subcontracting Consumer Work Cooperatives (Please First read the precautions on the back of the page and then fill in this page). Use the 7-L-MP in Example 7, which means that there will still be a dissolved drug in the base * 1 after 2 weeks. Therefore, it can be proved that i3-L-MP has practicality as a dissolving agent. Test Example 2 (Adhesion Test) For the porridge of Examples 1 to 4 and Comparative Examples 1 to 3, check its adhesion and- 6 1-This paper is based on the Chinese National Standard (CNS> Λ4 size (210X297 mm) A7 B7 V. Description of the invention (60) Time-dependent change in adhesive strength * and experiments based on the Hichiban Rolling Ball method "This Method: Draw a day sine curve from a certain height at an angle of 30 degrees to make the ball rotate, and determine the distance traveled from the sample to the point》, that is, the shorter the distance or the larger the ball, the better the adhesion. Good adhesion. In this test, the length of the sample was cut to 140 m to make the adhesive surface stretch to form a surface state. The stainless copper ball was rotated (20/32: JIS standard) and measured. The forward distance. The results are shown in Table 2. Table 2 (Please read * ^ 8 on the back of the note and write this page again)-the initial adhesion of the porridge produced by the shelling consumer cooperative of the Central Rubbing Bureau of the Ministry of Economic Affairs ( ™) 40 ° C, after 6 months (Ming) Example 1 50 48 Example 2 30 33 Example 3 35 38 Example 4 4 3 4 1 Comparative Example 1 98 95 Comparative Example 2 78, 82 Comparative Example 3 The porridge of Examples 1 to 4 passed through as described above has good stickiness and acceptable changes over time. Standards: Chinese National Standard (CNS) A4 specification U10X297 mm) Amendment # #Each 4. Contains. Is A7 Supplement B? V. Description of the invention (slave) Test example A (piper safety test) For implementation The porridge cocoons of Examples 1 to 4 and Comparative Examples 1 to 3 • Peel safety test was performed. 25 males and females of Kang Zhi were subjected to a closed-type sigh test to observe the male male and 1 male and 24 hours after menstruation. The degree of change of the post-piper, according to the description of Biaohua, evaluates the degree of irritation of the piper, and the results are shown in Tables 3 to 4--: There is a change in the virility on the piper + ... There is a significant red on the piper ±: A thin red ++ appears on the prisoner: there are heavy spot rashes on the skin. Table 3 (# ¾¾ Note from this book? Yuan? Help? The rate of stamping is Λ Workshop Fee Cooperative Cooperative Seal «. After the departure Time-to-Evaluation Test + + + Total number of persons (person; Sexual slaughter (% >) 1 hour or more to implement 1 0 0 0 25 25 0.0 1 hour example 2 0 0 1 24 25 4.0 1 Real-time planing 3 0 0 0 25 25 0.0 1 Small Example 4 0 0 0 25 25 0.0 1 hour comparison #i 1 0 0 2 24 25 8.0 1 hour comparison for 2 0 0 1 24 25 4.0 1 small comparison Hold 3 0 0 3 25 25 12.0 -63-order-good. This paper size is in accordance with Chinese National Standards (CNS) A4 (2 丨 0X297 mm) A7 B7 Revised on January 1, 2005 Explanation (62) Table elapsed time after the peeling of the evaluation sample + + + soil-total (person) 陲 rate (%) person or more 2 4 hours Example 1 0 0 0 25 25 0.0 2 4 hours Example 2 0 0 0 2 5 25 0.0 2 4 hours example 3 0 0 0 25 25 0.0 2 4 hours example 4 0 0 0 25 25 0.0 2 4 hours comparative example 1 0 0 1 24 25 4.0 24 hours fcb comparative example 2 0 0 0 25 25 0.0 2 4 hours Comparative Example 3 0 0 1 24 25 4.0 Please A Η A · Note Note f This page is as described above. The porridges of Examples 1 to 4 are extremely safe for skin test醅 Example 4 (Percutaneous absorption test for humans) The specimens of Example 4 and Comparative Example 2 were punched into 3X3C · 2 and attached

On the upper back of 8 healthy volunteers, they were recovered after 8 hours, and they were disabled children according to HP LC \ Legal Ketone Pufan (Uetoprofen). The absorption rate of the human body • Conversion of *, method of determination and HPLC conditions are as follows: ⑴ Yield of the human body = (1-residual initial content) X100 ： Dingli method: the recovered sample is 70b1 in alcohol. After performing reflux extraction for 2 hours, the 100 · 1 formazan after extraction was used as the sample for HPLC · -64- This paper size is in accordance with China National Standards (CNS > Α4 size (2 丨 0X297 mm) \ Economy The prints of the Ministry of Industry and Commerce Cooperative Cooperative are shown in Table 5, and Example 4 using 3-L-MP as a dissolving agent showed higher absorption than Comparative Example 2. MM mm B The hard buds of Example 9 and Comparative Example 6 were stored at 5 ° C, and the change with time of crystallization was observed. The results are shown in Table 6. Table 6 Printed by the Shellfish Consumer Cooperative of the Central Bureau of the Ministry of Economic Affairs

The initial sample of time-lapsed samples is 1 day, 3 days, 7 days, and 14 days. Acetonitrile = 55: 45 Detection wavelength: 254η · Column: TSK gel ODS-80TM, Flow rate: 1.0 # 1 / 兰 i η Table 5 Human Absorption Rate (% > Example 4 12.7 Comparative Example 2 5. 0 This paper uses the Chinese National Standard (CNS) Λ4 specification (210 × -2β® ^ Ι) (Please read the note on the back before filling this X)

Printed by the Ministry of Economic Affairs of the Bureau of Quasi Bureau Shellfish Consumer Cooperatives A7 ___B7______ V. Description of the Invention (64) From the results in Table 6, it can be seen that Comparative Example 6 without the addition of dissolve is more suitable for die lofenac ) Shows the existing crystallization effect with time, while Example 9 was dissolved in the substrate. That is, the effectiveness of the antidote is shown. TEST_EXAMPLE 6 The percutaneous harvesting test of human Huan The specimens of Example 9 and Comparative Example 6 were perforated to a size of 3 × 3 c * 3 and attached to the backs of 6 healthy volunteers. The conversion of the residual amount of diclofenac to the absorption rate of the human body, quantitative method, HPLC conditions are as follows. ⑴Absorption rate of human body = (1-residue / initial content> X 1000) Quantitative method: Perform ultrasonic extraction of 2 with 30b1 tetraargonfuran, and 50 · 1 tetragasfuran after extraction As a sample for HPLC. ⑶ HPLC conditions Mobile phase: 0.2 χ acetic acid aqueous solution · acetonitrile = 1: 1 Detection wavelength: 275 nffl Column: TSK gel 0DS-80TM Flow rate: I / ain The results are shown in Figure 1. The figure shows that Example 9 has a significantly higher absorption situation compared to Comparative Example 6 β, that is, Example 12 has a good release phenomenon due to the dissolution of 3_L-MP, and diclofenac is present in a dissolved state. Test Example 7 Store Example 77, Implementation Example 80, Comparative Example 7, Comparative Example-6 6 under 5Ό _ This paper size applies the Chinese national standard ^ CNS M4 & (210X297 mm) — (Please read the note on the back first Write this page again) Order A7 _B7_ V. Description of the invention (65) 8 for each bag for 2 weeks, observe the crystallization results of fat-soluble powder over time as shown in Table 7 ^ Table 7

-Initial day 1 day 3 days 7 days 14 days Example 77 0000 Example 80 0000 Comparative example 7 XXXXX Comparative example 8 XXXXXX Please listen to the noodles · Note boxing-item, and then set the central standard of the Ministry of Economic Affairs Printed by the local shellfish consumer cooperatives 0: No crystallization is considered X: There is crystallization. From the above results, it is known that 3-L-MP is used as a dissolving agent to show its usefulness. Test Example 8_ Targeted at 10 female volunteers Each bag of Example 7 7 and Comparative Example 7 was used to perform a functional test. The results are shown in Table 8. -6 7 _ This paper size applies the Chinese National Standard (CNS) A4 specification (210X297 mm) -62-V. Description of the invention (66) A7 B7 Table 8 Example 77 Comparative Example 7 Odor has 0 person 0 10 people, 10 people, 10 people, 0 people, 0 people, 10 people, irritability, 0 people, 0 people, 10 people, 10 people, sticky feeling, 0 people, 1 person, no 10 people, 9 people, no slippery feeling, 1 person 8 There are no 9 people and 2 people (please read the note on the back before filling this page). The above results are printed by the Central Ministry of Economic Affairs, Central Bureau of Work, Consumer Cooperatives, and the results show that the bags in the examples have a clear price. There is no precipitation of crystals of fat-soluble powder, so it has excellent texture. Effect of the Invention The present invention is mixed with 3-L -methyl propane-6 8 which has been used as a cooling agent in the past. The paper size is in accordance with China National Standard (CNS) A4 (210X297 mm) A7 B7 5 、 Explanation of the invention (67) Alkan-1, 2-diol is a dissolving agent of active ingredients, so it has excellent dissolving effect of active ingredients, and has a high degree of safety, stability and compatibility. It is also used as a percutaneous absorbent. External preparations can improve the release of the active ingredients and transdermal absorption. Also, it can eliminate side effects such as skin rash caused by repeated application of external preparations. It does not irritate the skin and is highly safe. Β This external preparation has no odor and has a pleasant cooling feeling β. Therefore, the external preparation of the present invention is suitable for use as a transdermal absorbent or a bagging agent, and has extremely high industrial application value. Brief Description of the Drawings Fig. 1 is a graph showing absorption rates of the hard buds of Example 9 and Comparative Example 6 on the human body. (Please read back * -Note I and then 1 page) Ordered by the Central Government Bureau of the Ministry of Economic Affairs, printed by Shelley Consumer Cooperatives -69- This paper size is applicable to China National Guidelines (CNS > Α4 size (210X297) 83.3.10,000 Article 8310428491 ♦ Case Study i ^ Skin Absorption Test Supplementary Example of the Test Method for Transdermal Absorption Test on Human Eel in 5 Healthy Adults The forearm is bent with white vaseline as a 1.4X 1.4ca plaque In this plaque, the liquid preparation examples 69, 73, and 74 were filled with the preparation of the non-sealed coating part of the micro-injection cylinder and inserted into a 25 ml flask to repeat the washing and recovery operation. The recovery operation was performed immediately. The volume was put into a test tube with a supersonic liquid collection, and each was coated with 20 w 1. 'Alcohol • water (1: 1). The tube was drained 3 times from the funnel to become the recovery liquid. As the initial content .Echo treatment 1 hour after adding 50 «1 overnight containing the remaining t after g) wipe the gauze 3 times with a bucket foot injection with alcohol in the Aioka method in the coating liquid receiver made of alcohol 25 and placed. 1 Bl Alcoholic solution of quasi-substance, after filtering through ACROLC 13 Set conditions shown drug determined by HPLC, and the amount of the residual group obtained by percutaneous absorption amount (rate).

Conditions for HPLC • _ Pump: Model 60C0A (Waters) Injector ODS-60TM (T0S0) 4.6mtfn XD # > < 15cm (5pm) Mobile phase: Acetate buffer (pH 3.2): CH ^ CN = Flow rate: 1.0 ml / min UV detection; 254 nm Column temp *: 35 * C. Tested agent ① The rubbing agent of Example 69 ② The spraying agent of Example 7 3 [the original liquid before filling in the spray container (except dimethyl ether and liquefied petroleum gas used as a spraying agent)] ③ The makeup of Example 74 Formulation of aqueous solution ① Formulation of Example 69 except 3-L-MP (Comparative Example 1) ② Formulation of Example 73 without 3-L-MP (Comparative Example 2) ③ Formulation of 3-L-MP Example 74 Formulation (Comparative Example 3) (Results) * The formulation of Example 69 The comparative example 1 The absorption rate of the formulation 25.3S; The absorption rate 18.5S! * The formulation of Example 73 The comparison example 2 The formulation absorption rate 23. 7¾ Absorption rate 17. 8J; * The preparation of Example 74 Comparative Example 3 The absorption of the preparation 26. U absorption rate 19. 3¾ Human absorption rate = (1-residual amount / initial content) X100 Test method for percutaneous absorption of human body Adhesion to the flexion of the forearm on the right and left wrists of 5 healthy adults with a space of 1.4X1.4cro Adhesive tapes were applied to the divided areas in a non-sealed manner using a spray cylinder and coated with 20 / i 1 of Examples 49, 51, 54-A and 56 respectively.歴 4 hours later -2- Wipe the preparation remaining in the application part with a gauze containing alcohol · water (1: 1) 3 times and insert it into a 25ml beaker. The infusion funnel was filled with alcohol from the funnel feet, and the washing and recovery operation was repeated three times to obtain a recovery liquid. In the same manner, the recovery operator performed the initial content immediately after coating. Add the recovered liquid to a fixed volume of 25 ml, and then treat it with ultrasound for 1 hour, then place it overnight. Take 1 nl of the recovered solution and place it in a test tube, add 50 μ1 of an alcohol solution containing an internal standard substance, filter it with ACROLC 13 and measure the drug placement by HPLC under the conditions shown below, and determine the percutaneous absorption (rate) based on the remaining placement. Conditions for HPLC

Pump: hudel 6CC0A (Waters) Injector: WISP 712 (Waters) Detector i Loubde-ioax model (Waters) Integrator: D-2500 (Hitachi) Column όν & η: TCM (Waters) Column: TSK-gel ODS-βΟΤΜ (T0S0 ) Λ.βιιϊη ID # 15cm (5pn)

Mobile phase: Acecate buffer (pH 3.2): CH ^ CN-A: 6

Flow rate: 1.0 ml / min UV detection: 254 nm

Column temp <: 35 ° C Test agent Preparation of the present invention ① The ointment of Example 49 ② The gel of Example 51 -3- S8G033 ③ Buy the gelatinous emulsion of Example 54-A (in Example 54 In the prescription, ketoprofen was used instead of indometacin. ④ Formulation of Comparative Example of Emulsion of Example 5 6 ① Example of Removing 3-L-MP ② Removing of 3-L Example of -MP ③ Example of removing 3-L-MP ④ Example of removing 3-L-MP (Result) * The absorption rate of the preparation of Example 49 was 19.5% * The absorption rate of the preparation of Example 51 1 39 3¾ * The absorption rate of the preparation of Example 54-A 31. 2¾ * The absorption rate of the preparation of Example 5 6 28.7S; the absorption rate of the human body = (1-49 prescription preparation (Comparative Example 4) 51 prescription preparation (Comparative Example 5 ) 54-A prescription preparation (Comparative Example 6) 56 prescription preparation (Comparative Example 7) The absorption ratio of the preparation of Comparative Example 4 14. 3¾ The absorption ratio of the preparation of Comparative Example 5 29.7 The absorption ratio of the preparation of Comparative Example 6 24. U Compare The absorption rate of the preparation in Example 7 20. U stock / initial content) X 100 4

Claims (1)

Cancer-Ben 386033 B8 C8 D8 A8 The town invited members to cut-a 'c'li within the original substance. The standard bidding rate in the Ministry of Economics and Trade is the stamp of the consumer cooperative cooperatives. * Application for patent Fangu No. 83104284K "Percutaneous absorption pharmaceutical composition" patent case (85 years (Amended on August 16) 5 Scope of application: Percutaneous absorption of pharmaceutical composition, you can take porridge, ointment _, ointment, sleep agent, emulsion, gel-like milk • lotion, spray Agents • Yu "type patches, wipes and other dosage forms • and its active ingredients are 蘧 from steroid bars anti-inflammatory 糸, non-steroidal bars anti-inflammatory 剤 and its ester derivatives, anti-mutation K resistance, anti-BU4 , Central nervous system agents, tinctures, antihypertensive agents, cardiotonic agents, anti-aggravating pulses, coronary vasodilators, local anesthetics, analgesics, osteopathic relaxants, antifungal agents, anti-malignant swelling, urine Incontinence agent, tincture agent, anti-Parkinson's disease agent, smoking cessation subsidy, vitamins and prostaglandins are medicinal ingredients, and the special emblem is that the active ingredient contains 0.1 to 20 weight ft% of 3- L- | [[Oxypropane-1,2-diase] is used as the soluble ingredient of the active ingredient. 2. The percutaneous absorption pharmaceutical composition as described in item 1 of Shen Zheli Fan Painting, wherein the dosage form of the percutaneous absorption agent is porridge two hours, that is, adding 3-Lf oxypropane-1, 2-di Fermentation and medicinal ingredients combined with at least one water-soluble polymer, stepwise fermentation and water. 3. For example, apply the percutaneous absorption medical composition of No. 1 Fanli Xian, in which the type of percutaneous absorption _ of _ is a plaster ointment. That is, add 3-Lt oxypropane-1, 2- Dienzyme is an effective ingredient, and is mixed with at least one rosin ester derivative, styrene-isoprene-styrene segmented poly paper size, using China National Tree Rate (CNS) A4 specification (210x297 mm) ^ ------ Equipment ---- ： 丨 丨 Order ------ A (First read the note of ΛΓ before reading the item ^ 4 and then write this page) Cancer-Ben 386033 B8 C8 D8 A8 The town invited members to cut-a 'c'li within the original substance. The standard bidding rate in the Ministry of Economics and Trade is the stamp of the consumer cooperative cooperatives. * Application for patent Fangu No. 83104284K "Percutaneous absorption pharmaceutical composition" patent case (85 years (Amended on August 16) 5 Scope of application: Percutaneous absorption of pharmaceutical composition, you can take porridge, ointment _, ointment, sleep agent, emulsion, gel-like milk • lotion, spray Agents • Yu "type patches, wipes and other dosage forms • and its active ingredients are 蘧 from steroid bars anti-inflammatory 糸, non-steroidal bars anti-inflammatory 剤 and its ester derivatives, anti-mutation K resistance, anti-BU4 , Central nervous system agents, tinctures, antihypertensive agents, cardiotonic agents, anti-aggravating pulses, coronary vasodilators, local anesthetics, analgesics, osteopathic relaxants, antifungal agents, anti-malignant swelling, urine Incontinence agent, tincture agent, anti-Parkinson's disease agent, smoking cessation subsidy, vitamins and prostaglandins are medicinal ingredients, and the special emblem is that the active ingredient contains 0.1 to 20 weight ft% of 3- L- | [[Oxypropane-1,2-diase] is used as the soluble ingredient of the active ingredient. 2. The percutaneous absorption pharmaceutical composition as described in item 1 of Shen Zheli Fan Painting, wherein the dosage form of the percutaneous absorption agent is porridge two hours, that is, adding 3-Lf oxypropane-1, 2-di Fermentation and medicinal ingredients combined with at least one water-soluble polymer, stepwise fermentation and water. 3. For example, apply the percutaneous absorption medical composition of No. 1 Fanli Xian, in which the type of percutaneous absorption _ of _ is a plaster ointment. That is, add 3-Lt oxypropane-1, 2- Dienzyme is an effective ingredient, and is mixed with at least one rosin ester derivative, styrene-isoprene-styrene segmented poly paper size, using China National Tree Rate (CNS) A4 specification (210x297 mm) ^ ------ Equipment ----: 丨 丨 Order ------ A (read the note of ΛΓ first and then write this page first) The central standard of the Ministry of Economic Affairs Printing crack «86033 '—---- Applicable patent scope compound or propylene 4. If applying for a patent, the percutaneous absorption of air base has high-level fat 5 · If applying for benefit, the percutaneous absorption of 3-L- | 6. If applying for a patent, the transdermal absorption of Lf gas-based propylated fatty acids 7. If applying for a patent, the transdermal absorption of 3-oxygenated lipids. 8. Ruo Shenli The transdermal absorption of 3 · L gas combined with lower enzymes 9. Ruo Shen patent A8 B8 C8 D8 acid strip adhesive and soften the skin. Transdermal absorption of item 1 of the country _ Preparation of the formulation is soft lei er, propane-1, 2-diase and pharmacologically effective acid or its ester, '' class, percutaneous absorption of item 1 of the interface activity range 窠When the tincture type of the preparation is a gelling agent, propane-1, 2-dioxin forms water with a medicinal effect, a tinting agent and a neutralizing agent. Transdermal absorption of item 1 of the scope _ Preparation of the product in the form of milky, diane-1, 2- dienzyme and medicinal ingredient esters, water, hydrogenated hydrogen and emulsifiers of the transdermal absorption preparation of item 1 of the scope The dosage form is a base emulsion of propane-1, 2-di-enzyme and high-efficiency fatty acid esters, a lower enzyme, and an emulsifying composition. Among them, the base is added, and at least the agent and the hydrogenated compound are mixed. . Add the chemical composition to the base, and mix at least the chemical composition, add 3- to the base, and mix at least one. The chemical composition, that is, adding ingredients to the base agent, and at least mixing, neutralizing agent, and the transdermal drug receiving composition of item 1 of the chemical conversion range, wherein when the dosage form is a lotion, In this base, add propane-1, 2-dienzyme and effective ingredients, and mix at least water and / or aglycone. The percutaneously absorbable pharmaceutical composition of item 1 of the fan plaque, in which the paper size is applicable to the Chinese National Standard (CNS > A4 specification (2 丨 0X297 mm) — ϋιϋ I—ί, containing 11 r--(please listen first Read the note on the back of the page, and then f on this page) Order a86033 B | D8 々, apply for patent scope The type of the percutaneous absorption splitting agent is spraying agent 畤, that is, 3-Lf ^ -based propane-1 is added to the base 2 · • Secondary medicinal ingredients, and at least mixed with surfactants, lower enzymes and / or dioxins, water and propellants. 10. Transdermal absorption as described in item 1 of Shenyang Patent Fanyuan Pharmaceutical composition, in which the percutaneous absorption of the rain type is a germanium amount type attachment, the base is added with 3-L- | air-based propane-1, 2-disease and effective ingredients , And at least mixed with adipic enzymes, lower enzymes, water and water-soluble polymers. 11. For example, the percutaneous absorption pharmaceutical composition of the first patent application, wherein the dosage form of the percutaneous absorption cleaving agent is rubbing When the agent is used, add 3-L-I " air-based propane-1, 2-secondase and medicinal ingredients, and at least alcohol and water fatty acid ester are mixed. Transdermal absorption_scientific composition of item 1 of Shen Lili, where the above medicinal ingredient 效 is water-insoluble or insoluble fat-soluble powder, and the dosage form is porridge. 13. If applying for item 12 of the scope of benefits A percutaneous absorption pharmaceutical composition, which contains 0.1 to 5 weight Λ% of 1,2-propane 1,2-diol in the above-mentioned porridge. The central standard of the Ministry of Economic Affairs and Consumers Cooperatives% *. (Please read first Back «Γ of note | item again * write this page) · 14. If you apply for a percutaneous absorption pharmaceutical composition under the scope of the patent application No. 12 or No. 13, in which the above-mentioned porridge is used, the fat-soluble powder is at least 僳Selected from glycyrrhizin, glycyrrhizin stearate, glycyrrhizic acid, L-ascorbic acid stearate, L-ascorbic acid palmitate, calcification age, K bone enzyme, biotin, iso For benzyl methylphenol. This paper size is applicable to China National Kneading (CNS) A4 size (210X297 mm)