TW369540B - New adenylate analogs derivatives and usage thereof - Google Patents

New adenylate analogs derivatives and usage thereof

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Publication number
TW369540B
TW369540B TW085104442A TW85104442A TW369540B TW 369540 B TW369540 B TW 369540B TW 085104442 A TW085104442 A TW 085104442A TW 85104442 A TW85104442 A TW 85104442A TW 369540 B TW369540 B TW 369540B
Authority
TW
Taiwan
Prior art keywords
new
adenylate
usage
adenylate analogs
hydrocarbon radical
Prior art date
Application number
TW085104442A
Other languages
Chinese (zh)
Inventor
Ji-Ru Hu
Gholam H Hakimelahi
Shwu-Chen Tsay
Original Assignee
Nat Science Council
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nat Science Council filed Critical Nat Science Council
Priority to TW085104442A priority Critical patent/TW369540B/en
Application granted granted Critical
Publication of TW369540B publication Critical patent/TW369540B/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A kind of adenylate analogs derivatives with the provided formula (I) in which R1 represents hydrocarbon radical, C1-C4 alkoxyl or -NHR3COOR4 amino ester wherein R3 is C1-C4 tetraalkyl and R4 is C1-C4 alkyl; and, R2 is hydrocarbon radical -O+NH4 aminoxyl or the formula (II) indicated in claim 1. The invention provides the new adenylate analogs which can be used as effective component for antiherpes virus via the combination therapy by linking the acyclic adenosine and arabinoside with phosphonate. The cellular toxicity is rather low especially with better lipophilicity and water-solubility of diadenylate phosphoramidate so as to increase the antibacteria activity.
TW085104442A 1996-04-13 1996-04-13 New adenylate analogs derivatives and usage thereof TW369540B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
TW085104442A TW369540B (en) 1996-04-13 1996-04-13 New adenylate analogs derivatives and usage thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
TW085104442A TW369540B (en) 1996-04-13 1996-04-13 New adenylate analogs derivatives and usage thereof

Publications (1)

Publication Number Publication Date
TW369540B true TW369540B (en) 1999-09-11

Family

ID=57941403

Family Applications (1)

Application Number Title Priority Date Filing Date
TW085104442A TW369540B (en) 1996-04-13 1996-04-13 New adenylate analogs derivatives and usage thereof

Country Status (1)

Country Link
TW (1) TW369540B (en)

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