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Pharmaceuticals Containing Other Organic And Inorganic Compounds
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Epoxy Compounds
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Abstract
This invention discloses novel methods for the preparation of key intermediate, (4S,5R)-2,4-diphenyl-5-carboxy-oxazoline derivatives, for the semisynthesis of Taxol. Chiral (2R,3S)methyl trans-3-phenyl-2,3-epoxypropionate was converted to (4S,5R)-2,4-diphenyl-5-methoxycarbonyl-oxazoline via Ritter reaction. Hydrolysis of methyl ester yielded (4S,5R)-2,4-diphenyl-5-carboxy-oxazoline which has been used in the semisynthesis of anticancer drug Taxol.
TW085106170A1996-05-241996-05-24Process for the preparation of (4S,5R)-2,4-diphenyl-5-carboxy-oxazoline derivatives as taxol side-chain precursor
TW363058B
(en)
Process for the preparation of (2r, 3s) -3-benzoylamino-2-hydroxy-3-phenylpro-pionate trihydrate of 4,10-diacetoxy-2alpha-benzoyloxy-5beta, 20-epoxy-1,7beta-dihydroxy-9- oxo-tax-11-en-13alpha-yl.
Tin-mediated enantioselective aldol-type reaction for the asymmetric synthesis of α-substituted serines utilizing an external chiral ligand,(−)-sparteine
Stereochemical aspects of catalytic siloxymethylation of various oxygen-containing compounds with hydrosilanes and carbon monixide in the presence of hydrosilanes and carbon monoxide in the presence of dicobalt octacarbonyl