TW363058B - Process for the preparation of (4S,5R)-2,4-diphenyl-5-carboxy-oxazoline derivatives as taxol side-chain precursor - Google Patents

Process for the preparation of (4S,5R)-2,4-diphenyl-5-carboxy-oxazoline derivatives as taxol side-chain precursor

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Publication number
TW363058B
TW363058B TW085106170A TW85106170A TW363058B TW 363058 B TW363058 B TW 363058B TW 085106170 A TW085106170 A TW 085106170A TW 85106170 A TW85106170 A TW 85106170A TW 363058 B TW363058 B TW 363058B
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TW
Taiwan
Prior art keywords
diphenyl
carboxy
preparation
oxazoline
chain precursor
Prior art date
Application number
TW085106170A
Other languages
Chinese (zh)
Inventor
Yu-Lin Yang
Ay-Hua Kao
Original Assignee
Ind Tech Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ind Tech Res Inst filed Critical Ind Tech Res Inst
Priority to TW085106170A priority Critical patent/TW363058B/en
Application granted granted Critical
Publication of TW363058B publication Critical patent/TW363058B/en

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  • Epoxy Compounds (AREA)

Abstract

This invention discloses novel methods for the preparation of key intermediate, (4S,5R)-2,4-diphenyl-5-carboxy-oxazoline derivatives, for the semisynthesis of Taxol. Chiral (2R,3S)methyl trans-3-phenyl-2,3-epoxypropionate was converted to (4S,5R)-2,4-diphenyl-5-methoxycarbonyl-oxazoline via Ritter reaction. Hydrolysis of methyl ester yielded (4S,5R)-2,4-diphenyl-5-carboxy-oxazoline which has been used in the semisynthesis of anticancer drug Taxol.
TW085106170A 1996-05-24 1996-05-24 Process for the preparation of (4S,5R)-2,4-diphenyl-5-carboxy-oxazoline derivatives as taxol side-chain precursor TW363058B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
TW085106170A TW363058B (en) 1996-05-24 1996-05-24 Process for the preparation of (4S,5R)-2,4-diphenyl-5-carboxy-oxazoline derivatives as taxol side-chain precursor

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
TW085106170A TW363058B (en) 1996-05-24 1996-05-24 Process for the preparation of (4S,5R)-2,4-diphenyl-5-carboxy-oxazoline derivatives as taxol side-chain precursor

Publications (1)

Publication Number Publication Date
TW363058B true TW363058B (en) 1999-07-01

Family

ID=57940839

Family Applications (1)

Application Number Title Priority Date Filing Date
TW085106170A TW363058B (en) 1996-05-24 1996-05-24 Process for the preparation of (4S,5R)-2,4-diphenyl-5-carboxy-oxazoline derivatives as taxol side-chain precursor

Country Status (1)

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TW (1) TW363058B (en)

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MM4A Annulment or lapse of patent due to non-payment of fees