TW354296B - 6,7,8,9-tetrahydro-5H-imidazo[1,2a]azepine-3-acetic acid derivatives, their preparation and their use in anaesthesia, hypnosis and anticonvulsant - Google Patents

6,7,8,9-tetrahydro-5H-imidazo[1,2a]azepine-3-acetic acid derivatives, their preparation and their use in anaesthesia, hypnosis and anticonvulsant

Info

Publication number
TW354296B
TW354296B TW086110878A TW86110878A TW354296B TW 354296 B TW354296 B TW 354296B TW 086110878 A TW086110878 A TW 086110878A TW 86110878 A TW86110878 A TW 86110878A TW 354296 B TW354296 B TW 354296B
Authority
TW
Taiwan
Prior art keywords
group
hypnosis
anaesthesia
anticonvulsant
azepine
Prior art date
Application number
TW086110878A
Other languages
Chinese (zh)
Inventor
Peretti Daniele De
Yannick Evanno
Odette Legalloudec
Mireille Sevrin
Pascal George
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo filed Critical Synthelabo
Application granted granted Critical
Publication of TW354296B publication Critical patent/TW354296B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

A compound of formula (I), wherein Z represents either a pheny group optionally substituted with one or two atoms or groups chosen from halogens and C1-C4 alkyl, methoxy, methythio, methylsulphinyl and methylsulphonyl groups, or a 5-methyl-2-thienyl group, R1 represents a hydrogen atom or C1-C4 alkyl group, a cyclopropylmethyl group, a phenylmethyl group or a pyridylmethyl group, and R2 represents a hydrogen atom or C1-C4 alkyl, in the state of free alkali or addition salt.
TW086110878A 1996-08-01 1997-07-30 6,7,8,9-tetrahydro-5H-imidazo[1,2a]azepine-3-acetic acid derivatives, their preparation and their use in anaesthesia, hypnosis and anticonvulsant TW354296B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9609702A FR2751970B1 (en) 1996-08-01 1996-08-01 6,7,8,9-TETRAHYDRO-5H-IMIDAZO [1,2-A] AZEPINE-3-ACETIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Publications (1)

Publication Number Publication Date
TW354296B true TW354296B (en) 1999-03-11

Family

ID=9494718

Family Applications (1)

Application Number Title Priority Date Filing Date
TW086110878A TW354296B (en) 1996-08-01 1997-07-30 6,7,8,9-tetrahydro-5H-imidazo[1,2a]azepine-3-acetic acid derivatives, their preparation and their use in anaesthesia, hypnosis and anticonvulsant

Country Status (6)

Country Link
AR (1) AR008133A1 (en)
AU (1) AU3853197A (en)
FR (1) FR2751970B1 (en)
TW (1) TW354296B (en)
WO (1) WO1998005664A1 (en)
ZA (1) ZA976828B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2783828B1 (en) * 1998-09-29 2000-11-10 Synthelabo 5,6-DIHYDRO-4H-IMIDAZO [1,2-A] [1] BENZAZEPINE -1-ACETIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
EP2010493B1 (en) 2006-04-12 2016-01-27 Merck Sharp & Dohme Corp. Pyridyl amide t-type calcium channel antagonists
KR20100072266A (en) 2007-10-24 2010-06-30 머크 샤프 앤드 돔 코포레이션 Heterocycle phenyl amide t-type calcium channel antagonists

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2593817B1 (en) * 1986-01-31 1988-04-15 Synthelabo DERIVATIVES OF TETRAHYDRO-5,6,7,8 IMIDAZO (1,2-A) PYRIDINE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Also Published As

Publication number Publication date
WO1998005664A1 (en) 1998-02-12
FR2751970B1 (en) 1998-08-28
ZA976828B (en) 1998-02-11
AU3853197A (en) 1998-02-25
FR2751970A1 (en) 1998-02-06
AR008133A1 (en) 1999-12-09

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