TW299230B - - Google Patents

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A6 299230 B6 V. Description of the invention (/) (Please read the notes on the back before filling out this page) The present invention relates to a mixture of higher aliphatic primary alcohols, which contains 22 to 38 sulfon atoms, especially 24 to 34 sulfonate Atomic alcohols, more specifically, straight-chain alcohols containing 24, 26, 27, 28, 29, 30, 32 and 34 atoms. The relative composition of the alcohols between batches of this mixture showed good repeatability. According to the present invention, the obtained high-grade aliphatic primary fermentation complex (hereinafter referred to as Μ.Η.PAA) has special pharmacological properties, so it can be used as an active component in pharmaceutical preparations to reduce anti-platelet enzymes and antiplatelets , Anti-thrombosis and / or anti-ischemia, as well as to fight the collapse caused by drugs and improve male sexual function. Sucrose wax and its natural source, cane puree, have always been the object of attention, not only because of their industrial use, but also because of their chemical composition. The content of panax in sugarcane is between 0.1% and 0.3%, depending on the species. In the industrial manufacturing process, only 40% of the pan content is diluted into sugar cane juice, and the rest is lost in bagasse. Printed by the Central Oak Quasi-Bureau of the Ministry of Economic Affairs of the 8th Industrial Consumer Cooperative. This is from 40%, 95% of which is absorbed by the sugarcane mud and made from the sugarcane mud. This flat is composed of esters, aldehydes, ketones, hydrocarbons, fatty acids and free alcohols, and the amount of each component depends on the variety and source of the sugarcane crop and the technology used to make the flat. Several authors have studied the straight-chain aliphatic alcohol obtained from this sugarcane by-product to understand its composition and main points of interest. Different combinations of chemical papers produced from various types of forging are applicable to the Chinese National Standard (CNS) A4 specifications (210 X 297 mm). The central standard of the Ministry of Economic Affairs is printed by the Beigong Consumer Cooperative Society A6 B6 V. Description of invention (1 ) Compounds have been reported (JALanberton et al., 1959; Australian J urna 1 〇f C hemistry, 13, 2 δ 1 2 6 8 and Η 〇rn A. and Mart ic JS, 19 5 7; Journal of Science Food and

Agriculture 10, 571), they proposed a method for preparing aliphatic alcohols from the sugarcane epidermis, which is to uniformly saponify the potassium hydroxide fermentation solution, then esterify the non-saponifiable substances, and then perform molecular distillation. This reported on another method for separating alcohol compounds by high-efficiency high vacuum distillation column. This pan distillation under high vacuum is used to chemically separate the carbonyl compounds and use petroleum ether to extract the remaining thumps. The solvent was evaporated, and the remainder was componentized for further separation by vaporized aluminum chromatography. Finally, the alcohol is hydrolyzed by adding alkali, and then recrystallized in ethanol, with a melting point ranging from 80 to 82. A method for obtaining higher aliphatic primary alcohols from animal flats and plant flats is based on the saponification of the aliphatic ester, followed by the use of an appropriate solvent, through a pressure of 60-300 kg / cm2, and a temperature between 25-1 00TC The critical and supercritical CO 2 fluids extract alcohol mixtures. This method shows that selective extraction can be performed at low temperatures depending on solubility and pressure refining. Using this method for sugarcane wax, a 5% C2 to C3 6 alcohol mixture can be obtained. Another design (Inada S, Furukawa K., Masui T., Honda k., Wgasawara J. and tsubikanato G., 1 9 8 5; method for recovering higher aliphatic n-primary alcohol, Japanese Patent 60 — 1 1 95 1 No. 4) A very similar method of wax extraction is proposed. The method applies the specifications of the national standard (CNS) A 4 (210 X 297 public goods) with the paper size (please pay attention to the precautions before filling in this Page) — Packing. Ordered · 299230 A6 B6 V. Description of the invention (">) (Please read the precautions on the back before filling this page) Ethylene is based on the subcritical and supercritical C02 stream. It has also been reported that flow plaques in subcritical and supercritical states have been used to separate organic compounds from warm compounds. From an analytical point of view, all of these are valuable methods, but the use of column chromatography and molecular steaming are all uneconomical methods that hinder mass production. One of the objects of the present invention is to obtain and to separate and purify a higher aliphatic primary alcohol (M.H.P.A.A.) with 24 to 34 atom atoms from two types of sugar cane forging, coarse cracked and refined flat. The method of the present invention is based on the method of homogenizing saponification of pre-melted sugarcane flats with alkali or alkaline earth metal hydroxides, especially low molecular weight, concentrated hydroxide solutions of sodium, potassium and calcium. The concentration of the hydrogen hydride solution printed by the Ministry of Economic Affairs of the Ministry of Economic Affairs must be such that the weight ratio of the sleeping hydrogen hydride to the flats to be processed exceeds 5%, especially from 8% to 25%. 15% to 25%. The saponification process is held for more than 30 minutes, especially from 2 to 5 hours. Place the solid obtained in this step in a solid-liquid extractor, and selectively extract Μ.Η.PAA with an appropriate organic solvent, the organic solvent is selected from 3 to 8 distillate atom ketone, 1 to 5 decanter atom alcohol , Hydrocarbons with 6 to 9 atoms, haloform and aromatic compounds, such as benzene and its derivatives, including mixtures thereof. Some of the solvents used in the present invention are the following: acetone, methyl ethyl ketone, amyl ketone, hexanone, heptanone, 2-methylpentanone, ethyl alcohol, methanol, 2-propanol, butanol, tert-butanol , Pentane, hexane, heptane, octane, gas imitation, 1, 2-two gas ethane, two atmosphere methane, three atmosphere ethane, 1, 2, 3_ three atmosphere propane, benzene, toluene, phenol The paper standard is applicable to the National Standard (CNS) A4 specifications (210 X 297 mm). A6 B6__ printed by the Beigong Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs. 5. Description of the invention (), p-methyltoluene and others. Extracted at 5 It takes up to 10 hours. Then, the product is crystallized with the above solvent or a mixture thereof. The yield is about 30%, and the purity of M.Η.PA Α. Is 80% to 98%, especially From 90% to 98%. The M.H.P · AA obtained in this way is composed of alcohols with 22 to 38 atoms. Yau is an off-white mixture with a melting point between 76.5 and 84. In order to use melting Condensation two gasification silicon capillary column was analyzed by gas chromatography, Μ · Η.PA A, using N-methyl_N-trimethylsilyl trifluoroethylene amide (MST F A) Derivative compounds. Compared with the previously reported, the method of obtaining M.H. PA Α. From the paniculata in the present invention has certain advantages. One of these advantages is the short processing time. Another of the present invention The advantage is the high yield (approximately 30% by weight) that can be achieved with this method. In contrast, the results of the previously introduced Sho et al. Report a yield of less than 5%. The advantages of the proposed method are: The purity of M.H.P · AA can be reached (nearly 98%), which is much higher than that reported by the current engineering level. Therefore, the method proposed by the present invention is higher than that of Inada et al. (Japanese Patent 60-1 1 95 14) and Hagiwara Y. (Japanese Patent 62-87537) are simpler and more suitable for large-scale production. Table 1 lists the M · Η · P · AA compounds obtained from sugarcane flats according to the present invention Qualitative and quantitative composition. T Table 1: Μ.Η.Ρ.Α · A composition used in pharmaceutical preparations. The paper size is applicable to the standard of CNS A 4 (210 X 297mm) ----------------------- installed ------ tr ----- two (please read the note Ϋ on the back first before writing page > A6 B6 V. Description of the invention () Qualitative and quantitative composition range The ratio of the components in the mixture 1 monotetracosyl alcohol 0.5-5.0% 1 monocosyl alcohol 5.0-1 5 . 0% 1 — octacosanol 0.5 .5-5. 0% 1 — octacosanol 5 0. 0 — 8 0. 0% 1 monocosanol 0.5 .3-3. 0% 1 — eicosanol 6. 0-2 0. 0% 1 ring tridecanol 1. 0-1 0. 0% 1 surface tridecanol 0. 0-2 · 5% Table 2 lists For a preferred M.H.P.AA composition isolated from sugarcane flats, Table 3 lists the most preferred M.H.P.A.A. compositions. Table 2: The ratio of the preferred qualitative and quantitative Fan Yuan components used in the drug splitting agent in the mixture ---------------- 1-- ------ Installed ------ 4? (Please read the precautions on the back before filling in this page) Printed by the Central Bureau of Standards of the Ministry of Economics and Industry and Consumer Cooperatives 1 -tetracosane yeast 0. 5 _ 1. 0% 1-hexacosanol 6. 0-8. 0% 1-icosanoyl alcohol 2.5-3. 5% 1 _ octacosanol 6 0. 0-7 0. 0 % 1 -cosacosyl alcohol 0.5 .1 _ 1. 0% 1 _ triacontanol 10. 0-15. • 0% 1 monotricosyl alcohol 4.5 .6. 0% of the paper size Applicable to China National Standard (CNS) A4 specifications (210 X 297 g; Ϊ) A6 B6 V. Description of invention ()

Printed by the Central Bureau of Standards of the Ministry of Economic Affairs β Industrial Consumption Cooperative Society S 1 — Sanyuanyuan Fermentation 0 • 5 Light 2 »5% Table 3 • Μ • Η • P • Λ • A used in pharmaceutical preparations The fcfc rate of the components of the fixed Fanyuan in the mixture 1 — twenty-four fermented yeast 0 »8 soil 0 • 1% 1 — twenty — alkane leaven 6 • 7 ± 0» 3% 1 — heptacosane leaven 3 • 0 soil 0-· 3% 1 — octacosanol 6 5 • 6 ± 3 • 4% 1 — behenadecanol 0 * 7 soil 0 • 1% 1 — triaconanol 1 2 * 5 soil 0 * 6% 1 — Thirty-two Houses of Fermentation 5 * 0 soil 0 ♦ 4% 1 — Thirty-four fields of leaven 0 hit 8 soil 0 • 1% work • Η • P • A • A and its medicines can be given to humans and Animal administration 〇M • Η • P • A • A Β agent placement is greatly affected by the actual condition of the disease and life to be treated t However, it is usually between 1 mg and 100 mg per day »Preferably about 3-20 mg 〇Μ > Η * P • A • A can be taken or parenteral administration 〇 优 m The route is Ρ The film-coated tablets and granules or medicaments contain 0 • 5% to 15% as the active component of the reset Μ • Η • P • A • A 〇 This dose is obtained by applying Μ • Η • P • A • A and various excipients (such as coagulant, disintegrant, mm agent> slip agent) or only mixed with fillers. These excipients include lactose Λ corn starch sucrose, stearin Acid mm crystal m vitamins, intermediary carboxylic acid (to read the precautions on the $ surface before writing this page) -installation- order · The paper size is applicable to China National Standards (CNS) A4 specifications (210 X 297 ) 299230 A6 B6 V. Description of the invention () Sodium quantite sodium, gelatin, cellulose acetate phthalate, titanium dioxide, talcum powder to be used for tablets and Glycol. The lipid-lowering effect of sugarcane flats has been confirmed in rats (Fukuda, the shadow depression of sugarcane flats on blood and liver fat in rats; Chemical Abstracts, 106, 17, 13 74 13 P; and Sho H. et al., 19845, Okinawan sugarcane scallion and lipase on the color retention of blood and liver fat in rats, J. Nutri. VitaDinol, 30, 6, 553-553) 〇 Initially, the color of sugarcane wax on blood and liver fat was high Male Wistar rats with vegetable and animal fat content were studied. Some authors found that adding 0.5% sugarcane to the fat of the prescribed food greatly reduced the blood triglyceride in rats starving for plant or animal fat, but only in the latter case was the amine sterol content apparent Reduced, and the content of liver fat is not affected. Therefore, these authors concluded that sugarcane flat has a hypolipidemic effect. On the other hand, Sho Η et al. (1984) studied the effect of Chong® sugarcane jelly on the blood and hepatic fat of rats fed 0.5% of this jelly food. They found that blood and liver Gum alcohol content is willing to reduce. This is true for the ytterbium tube. When the fatty alcohol obtained from the same type of panax is used in animal food, there is no significant change in the K-solid enzyme content. Therefore, they ruled out that the lipid-lowering effect of pan was caused by these enzymes. Printed by the Ministry of Economic Affairs ZTE Standard Bifang wcH Consumer Cooperative (please read the precautions on the f side before filling in this book) However, a few years later ShiBura S., Hagesawa. Τ., Takano S. and Susuki T. (1937: Coax the effect of octacosanol on the persistence of exercise in mice ίδ; Nutriti 〇n R e ρ rts I n t. 3 6, 1 0 2 9-1 0 3 8) Use * for physical activity and pavilion Mice who ate foods rich in octacosanol studied the specifications of this paper. The general Chinese National Standard Rate (CNS) A 4 specifications (210 X 297 mm) A6 ___B6 5. Invention description () (please read <; ^ * Precautions and then fill out this page) The influence of octacosanol. They found that octacosanol isolated from ganshu wax significantly reduced the content of triglycerides and knee zymosin in the liver However, the content of triglyceride in R was only significantly reduced. They concluded that the octacosanol isolated from the sugarcane has a lipid-lowering effect, which is different from the previous results of the obsessed Sho Η et al. The same , Another high-level aliphatic primary alcohol, hexacosanol, has also been shown to have anti-lipidic effects, although it has been reported that centipede is very high This effect can only be obtained in small amounts (10-30 mg / kg / day) (HagiwaraY.1987: used for anti-lipid agents containing hexadecane fermentation to treat hypertension, arteriosclerosis, diabetes, heart disease, and obesity; Japanese Patent A62 — 09932 3) 〇 There are various commercial lipid-lowering drugs that are considered to be safe, effective and well tolerated, but most of them produce various adverse side effects. Because lipid-lowering drugs must be taken for a long time, it is very important Printed by the Ministry of Economic Affairs, Central Standards Bureau's "Cooperative Society", for example, xylene gas enanthate reduces blood triglycerides, increases the height of lipoprotein amine sterol (HDL-C) containing fi, and makes blood solid 8S solid fermentation. It has been reduced, but several adverse effects have been reported. For example, the 5 intestinal effect, plus abdominal pain, diarrhea, nausea, vomiting, and flatulence have been reported. In addition, in patients treated with xylene gas enanthate Found headache, dizziness, blurred vision, impotence, decreased libido, and abnormal liver energy, such as transamin, dehydrolactate, creatine phosphate, and testosterone. Equally, patients with dysfunction cannot Taken. Probucol is another lipid-lowering drug with anti-gasification agent properties, which makes -10-this paper again applicable to China S Home Standards (CNS) A 4 specifications (210 X 297 mm). Printed by S Industry and Consumer Cooperatives »i < A6 _ B6_ V. Description of the invention () Blood stagnation sterol and low-density lipoprotein sleep solid fermentation (LDL-C) moderately reduced" However, one of its lack of viscosity It reduces the content of HDL-C. In addition, t reported that it has several adverse effects, such as gastrointestinal disorders in about 10% of patients, and considerable changes in electrocardiograms. The other commonly used lipid-lowering drugs are chloramidamine and Jiangyining P. They are effective and excellent cholesterol-lowering drugs, which strongly reduce blood cholesterol 8S solid enzyme and LDL-C, but will increase triglyceride content. These drugs can cause several bowel symptoms, mainly constipation. The compliance of the treatment is generally low because of the adverse symptoms, and they are not easy to take medicines, the box should be up to 12 to 20 grams per day to achieve the desired effect. In addition, it has been reported that they have undesirable chemical interactions with other drugs, such as digitoxin.

Lovastatin is a kind of "Statins", which is an inhibitor of HMGC0 A reductase, which can effectively reduce the content of serum sterols and LDL-C. It also moderately increases HDL-C and reduces triglycerides. Several side effects of this drug have been reported. For example, the main side effects are myopathy, low-to-moderate increase in creatine phosphokinase, and permanent increase in blood pressure, which is often irreversible after treatment is stopped. Myopathy mainly occurs in patients undergoing concomitant treatment with immunosuppressive drugs (such as xyloxyheptanoic acid or niacin). In addition, it has been reported that Lovas tat in treatment and patients, sensitive patients have side effects such as rash, pruritus, headache and severe muscle damage, resulting in myolysis. Furthermore, it has been reported that Junjiu atrophy and liver tumors related to drugs have occurred in laboratory animals. -11- The size of this paper is t S National Standard (CNS) Grade 4 (210 X 297 mm) (please read the precautions on the back and then this page) i install. Order. S Ministry of Economic Affairs Printed by the consumer cooperative A6 _ _ _B6__ V. Description of the invention () Similarly, Sievas tat in and Pravas tat in are the other two kinds of “Statins”, which act according to the same machine split as Uvas tat in, showing approximately the same The effect of reducing knee sterol. The side effects reported in these patients are the same as those treated with Uvastatin, but are reportedly milder. It is reported that patients treated with Simvastatin and Pravastatin have constipation, flatulence, nausea, headache, fatigue, subcutaneous rash and creatine Phosphokinase myopathy. On the other hand, it has been mentioned that certain lipid-lowering drug treatments reduce the tendency of platelets to excessively aggregate, which is common in patients with high blood pressure, and experimental data have shown an anti-aggregation effect regulated by these compounds. Nonetheless, only certain anti-steroidal drugs show this sex disorder. As already mentioned, atherosclerosis is a comprehensive result of a variety of changes in the endometrium of the animal. These compounds include lipids, complex water compounds, blood and blood products, fibrous components and local calcium deposits. Accumulation is often accompanied by medialization. Therefore, this definition indicates that atherosclerosis is a multi-factorial process, and it is not only best to use hyperlipidemia as a risk factor. Therefore, among the factors that contribute to atherosclerosis and development, platelet aggregation plays an important role. Platelet release contains slightly active arachidonic acid, which metabolizes and changes into ring-shaped peroxides. They are mainly converted into ring-shaped internal gasification compounds and eventually become thromboxane AZ) TxA z), which is a strong vasoconstrictor and platelet aggregation agent. There are various compounds that can induce platelet aggregation, such as plaque, adenosine diphosphate and epinephrine and others. Therefore, all kinds of "in vivo", "incubation" or "-12-" (please read the note on the back-item and then this page). 丨 installed. Ordered · This paper size applies to China National Standard (CNS) A 4 Specifications (210 X 297 g: ^) Printed by the RX Consumer Cooperative of the Central Bureau of Economic Development of the Ministry of Economic Affairs. $ A6 _B6_ V. Description of the invention () In-vitro test method to test the effectiveness of the hypothetical antiplatelet drug, usually to test the drug These tests on platelet aggregation induced by these compounds are also used to test platelet aggregation in healthy volunteers and patients who often induce hyperaggregation, such as patients with hyperglycemia and diabetes. Among these tests, mashogen-induced platelet aggregation is the most commonly used. For example, injecting collagen into urea causes irreversible platelet aggregation in blood vessels, and platelet aggregation enters the blood vessel circulation, thereby reducing circulating small blood counts and increasing the degree of malondialdehyde (M DA) in the plasma. . In addition, in some animals, injecting ® originally induced thrombosis and Dicheng died. In these wedges, antiplatelet drugs generally prevent the reduction of platelet content and the increase in malondialdehyde (MDA) concentration, as well as death caused by plaque. Certain drugs that prevent platelet aggregation can be used to treat thrombosis, myocardial infarction, and stroke, but they do not all have these advantages. On the other hand, some antithrombotic drugs mainly suppress the blood suspicion through the lysis process, rather than affecting platelet aggregation, such as _ kinase and urinary vine. Because ischemic cardiovascular disease, stroke, and terminal obstruction of blood vessels are the main posterior symptoms of atherosclerosis, testing several substances can also prevent the pathogenesis by acting on other phenomena involved in these processes. These complications must be beneficial to the treatment of these patients. Similarly, the reduction in ΤχΑζ content not only has anti-platelet and anti-thrombotic effects, but also anti-ischemic effects. The screening of anti-ischemic drugs usually includes -13- This paper scale is applicable to the China Sleepless Family Standard (CNS) A4 specification (210 X 297 gongs ») -------------- ----------- installed ------ order ------ 4 (please read the precautions on the back before filling in the clothing page) 299230 A6 _B6_ V. Description of the invention () Evaluate them Effect on induced cerebral ischemia p For example, it has been reported that various drugs have protective effects on rat brain ischemia, including some non-steroidal anti-inflammatory drugs (NSA ID) that inhibit the reaction catalyzed by cyclooxygenase And thromboxane synthase inhibitors and prostacyclin analogs (Pglz) (Borzeix MG and Cahn J., 1988, the new chemically metabolically stable prostacyclin analogues reduce transient brain blood volume in rats The role; Prostag 1 and. Ns 3 5,5,653 — 664 ·). Other experimental methods, such as cerebral ischemia induced by the Xinggu gerbil experiment, are also often used. Acetylsalicylic acid (ASA) is a compound that shows antiplatelet, antithrombotic and anti-ischemic properties in experimental models and human incubation. It is one of the most widely used drugs in the treatment of acute myocardial infarction and stroke and in preventing thromboembolic disorders. The role of AS A is influenced by its well-known inhibition of a key enzyme (chen oxygenase) in arachidonic acid metabolism. Therefore, ASA significantly reduced the content of thromboxane A2 (TXA2) in blood plasma, which is a recognized pathophysiological factor of vascular endothelium, and explained the above-mentioned role of ASA. Printed by the Central Standards Bureau of the Ministry of Economic Affairs: Printed by the Industrial and Consumer Cooperative (#Read the note on the back of the page before filling in this page) Moreover, the content & reduction of prostaglandin (P g Ιζ) • The latter is a compound whose pharmacological properties are opposite to ΤχΒζ. On the other hand, considering that ASA inhibits the synthesis of prostaglandins (Section E), it will prevent the cell protection of prostaglandins due to -14- This paper scale is applicable to the Chinese National Standard (CNS) A 4 specifications (210 X 297 goods>

The Ministry of Economy, Central Standard Housing, Employee and Consumer Cooperatives printed S A6 _B6_ V. Description of the invention () Causes stomach injury due to use. Liao is the main side effect reported on ASA, such as gastroenteritis, Fei ulcer and loss of symptoms. One of the objects of the present invention is to use a public discard 24 to 34 p.m. atomic M.H.P.A.A. as a drug splitting agent. Another object of the present invention is to use a relatively low amount of 24 to 34 tilt atoms of M.H.P.A.A. as the active composition for reducing knee sterol pharmaceutical preparations. Another object of the present invention is to use Μ.Η.PAA in anti-platelet, anti-ischemia or antithrombosis formation of phlegm to show the anti-platelet aggregation effect of Μ.Η.PAA. It was confirmed in the "in vitro" and "internal" models and in a series of different experiments in the human body. "Another object of the present invention is to confirm the protective effect of Μ.Η.PAA on experimentally induced ischemia." Another purpose is to confirm the pharmacological interaction between M.H. PAA and ASA, which is most commonly used in the treatment of cerebral ischemia. The results indicate that there is an acoustically identical effect between the antiplatelet, antithrombotic and anti-ischemic efficacy of M.H.P.A.A. and ASA. The present invention is also intended to confirm that Μ.Η.PAA significantly reduced by aspirin, ethyl yeast, indomethacin, compound C4880 (Siger Yan company) and other treatment of human ulcers produced S ulcers Caused by Jia ulcers. It has been reported that the ulcer induced by E.coli is mainly related to the increase of ΤχΑζ as a physiological factor, and the ulcer induced by C4800 -15- This paper standard general standard (CNS) A 4 specification (210 X 297 Ali) ---------------- 【------- installed -------- ordered (please read the $ item on the back and then fill in this page) 熳Printed by the Beibei Consumer Cooperative Cooperative Society of the Central Ministry of Economic Affairs * A6 __B6_ V. Description of the invention () The ulcer is mainly related to the mechanism of hemagglutinin activation, although the role of TχΑζ in male reproduction cannot be excluded. g — On the one hand, ASA-induced Fischer's ulcer is related to the inhibition of prostaglandin (E Shile) synthesis produced by ASA, because prostaglandins have a cytoprotective effect on Fischer's mucosa. It has been confirmed that Tx A2 and Ps IX play an important role in the mucosa as a contemporaneous endogenous mechanism. On the other hand, as mentioned earlier, some of the lowering substances that reduce zymogens impair male sexual function. For example, there have been reports of hyposexuality and impotence in patients treated with antomin and xylene. On the contrary, another object of the present invention is to confirm that M.H.P.A.A. not only does not impair male sexual function, but also enhances the sexual function of humans and animals. For example, it has been mentioned that many patients with high K sterols have increased sexual function during treatment in clinical trials. This effect has nothing to do with the change in serum levels of the main hormone involved in controlling libido and sexual behavior, military ketone. Army ketone is considered to be the main sex hormone in mammals to control libido. It has been reported that only a threshold level of ketone is needed for sexual function. Too much iperone does not lead to further enhancement of male sexual function. However, it has been proven recently that the same testosterone level contains different hormone release or administration methods, which may lead to different color effects on male sexual function. YI indicated that there are still opposing views in this regard. On the other hand, male sexual behavior in mammals includes different stages: libido, penile erection, orgasm, and ejaculation, which are controlled by complex neuroendocrine mechanisms. For example, this behavior is caused by acting on the final effect -1 6----------------- 一 ------- pretend ------- Γ ( Please read the precautions on the back first and then write the clothing page.> This paper scale is applicable to the Chinese National Standard (CNS) A 4 specifications (210 X 297 g **) A6 _B6__ 5. Description of the invention () (please smell 1! ^ Note ^ item 5 ^ this page) The release of testosterone on the organ is determined by the excitation and anti-hunger mechanism of the mid-planter nerve system mainly located in the central base of the hypothalamus. Both pathways and heme activation pathways control sexual function. Finally, it has been confirmed that the release of nitric oxide (NO) in sponges is a key mechanism of penile erection. Therefore, Μ.Η.PAA improves male sexual function The effect can be explained by another mechanism that has not been fully understood. Finally, in the azimuth tracing gun about the complete picture of Μ.Η.PAA, it has excellent safety and tolerability compared with the currently known drug orange. Represents an important advantage. For example, in acute, subchronic, and narcotic studies conducted with rodents, rabbits, ghost dogs, and monkeys, It is toxic to the drug. In addition, it has neither any mutagenic effect nor induced effect in rabbits or mice. Rats who took M. Η · PAA for more than two generations did not have a fetal flu, Nor does it affect Zhan's reproductive activity. Finally, a 24-month carcinogenicity study on mice also showed that MHPAA has no toxicity and carcinogenic effects. Short-term and long-term clinical trials also show that this treatment is extremely complete and well tolerated The Ministry of Economic Affairs Central Liang Junfang 8 Workers' Consumer Cooperative Society ® The purpose of the present invention will be described in detail in the following examples. These examples will not limit the scope of the present invention. Example 1 Take 1000 grams of cracked sugarcane ® in 100- Melt at 110¾, add 200 grams of potassium vapor dissolved in 150 ml of water. Stir--17- This paper scale is applicable to China National Standard (CNS) A 4 specifications m〇X 2S7 mm) A6 B6 V. Invention This process is maintained for 5 hours under the description (). The solid agent is extracted from the solid obtained by this process for hours. The obtained extract is crystallized from it in room A. The alcohol complex in methyl ethyl chloride; the purity is 94.80 Between 5 and 82.5TC Μ. Η. PAA's table 4: the resulting Μ. Η. P. A component < please read the $ 面 之 注 + W-item then $ 本 买 > one-liquid extraction system uses heptane as the solvent Take Μ • Η • P • A • A * 1 2 cooling at temperature »Μ • Η • P • A • medium recrystallization 〇 to get up to 2 8 5 g 70% 〇 The mixture of the viscosity range is listed in Table 4 Lists the properties obtained by this method and the determination of the composition of the ft. The qualitative and fixed composition of each leave is 100%. Fermentation 1 _ twenty-six yards of fermentation 1-twenty-t alkane fermentation 1 octacosanol 1 _ twenty-nine yards of alcohol 1 triosyl alcohol 1 tris-decanol 1 tris-tetracosanol Example 2 This saponification process was carried out by wrapping 2 kg of crude sugar cane flats in 200 ml of water for 4 hours. Extract Μ.Η.P. 0.81 7.00 2.81 6 5.09 0.67 12.43 5.05 0.84 85-1001C with an atmosphere extraction system, add 00 grams of sodium hydroxide, and hold the imitation as a solvent under conventional solid-liquid extraction A with stirring A. For 10 hours, apply the obtained 18-paper size to the Chinese National Standard (CNS) A 4 specifications (210 X 297 g *) A6 B6 5. Description of the invention () The extract is cooled at room temperature. The solid solution is recrystallized in methanol, and finally recrystallized in an atmosphere / methyl ethyl ketone mixture. 405 grams of M.H.P.A.A. with a total purity of 92.5 2% was obtained. M.H.P.A.A.'s viscosity range is from 79.0 to 80.51 :: Table 5 lists the qualitative and fixed composition of M.H.P · A · A. Obtained by this method. Table 5: The qualitative and qualitative composition of the obtained M. Η. PA A. The percentage content of each alcohol (please read the precautions on the back first and then 9 ^ 本 1> _twenty four alcohol hexacosane Fermentation 0.87 6.84. 丨 installed. Printed by the Central Standard House of the Ministry of Economy and Economy βτ Gong Consumer Cooperative Society «3.08 6 2.92 0.80 12.66 4.65 0.70 1 -twenty-t-alkanol 1 1,2-octadecane fermentation 1 129-alkanol 1 _3 Decakanol 1-Thirty-two House Enzymes 1-Thirty-four Tetracane Enzymes Example 3 Add 1 2 kg of calcium hydroxide dissolved in 7 liters of water to 50 kg and refine it by melting under 100-1 20 in advance In sugarcane cricket. This saponification process is carried out with stirring for 7.5 hours. In the solid-liquid extraction system, ethyl yeast is used as a solvent to extract Μ.Η.PAΑ. 12 hours. The resulting extract is at room temperature Leave it to cool, and then recrystallize the solid plaque in an atmosphere. The purity of 93.77% is obtained. M. Η. PA Α. 13. -19- This paper scale is universal Chinese National Standard (CNS) A 4 specifications (210 X 297 mm) Order-A6 _B6_ V. Description of invention () 7 kg. The melting viscosity range of this mixture is 80. 0-82. 0C. Table 6 lists the Μ.Η.P obtained by this method . The qualitative and quantitative composition of AA. Table 6: The percentage content of each enzyme of the qualitative and quantitative composition of the obtained M. Η. PAA (please read the precautions on the back before filling this page) 1 Twenty-four Alcohol 0. 7 1 1 Hexadecanol 6. 8 8 1 Hexacosane fermentation 3. 0 6 1 octacosane fermentation 6 4. 7 0 1 _29-hexacosanol 0. 6 2 1 Triacosane yeast 12. 0 1 1 _ tridodecyl alcohol 5. 0 9 1 tritridecyl alcohol 0.70 Example 4 The hydrogenation of 8.6 kg dissolved in 4.5 liters of water Calcium added to 5 packs · Ordered-1 Printed by the R & C Consortium, Central Bureau of Standards, Ministry of Economic Affairs

Kilograms are pre-melted in crude sugarcane flats that melted at 100-120TC. The soap process is carried out for 3 hours with continuous stirring. In a solid-liquid extractor, dichloromethane was used as a solvent for 12 hours for extraction. The resulting product was cooled to room temperature, and the obtained solid was recrystallized in a mixture of hexane and propylene (1: 1). 8 kilograms of alcohol complex with a purity of 92.91% was obtained. 5C-80. 5C。 The melting point of Μ.Η.P.A.A. is 78. 5C-80. 5C. Table 7 lists the qualitative and qualitative -20 of Μ.Η.PAA obtained by this method- This paper scale is applicable to the Chinese National Standard (CNS) A4 specifications (210 X 297 g; ϊ) 299230 A6 B6 V. Description of the invention () Quantity composition. Table 7 ·· The obtained qualitative and quantitative composition of M. Η. PAA The percentage content of each alcohol 1 Home Enzyme 1 — Printed by the Central Standard House of the Ministry of Economy, Ministry of Economy, and Twenty-nine Homes, and printed by the Cooperative Consumer Cooperative 1 _ Thirty-Okane Enzyme 1 Tridecanol 1 _ Tridecane Enzyme Example 5 To 20 kg in advance in 1 00_ Box cracked sugar cane wax was added diluted with 3.0 potassium sulphate. During the saponification process, the solvent is added under continuous stirring, and M. is extracted in the Soxhlet extractor. The extracted material was recrystallized at room temperature in a cold «imitation (1: 1) mixture of% M.H. PAA 3. .A.'S melt-adhesive Fan Yuan at 78.5 and out of this method obtained Μ. Η. P composition. -2 Ι Ο. 7. 3. 6 3. 0. 12.4. 0. 7 5 0 0 14 6 0 6 2 0 3 9 9 7 8 3. 7 kg of E oxygen in molten water melted at a temperature of 110C 5 hours. Use methyl ethyl ketone as H. P. A. A. Next, place it in hexane / to obtain a purity of 92.56 8 kg. M. H. P. A 80. 5¾. Table 8 lists the qualitative and quantitative of AA (please read the precautions on the back and then fill out this page) 丨 installed. Ordered · This paper uses the Chinese Garden Standard (CNS) A 4 specifications (210 X 297 mm) A6 B6 V. Description of the invention () Table 8: The qualitative and quantitative composition of the obtained M. Η. PAA The percentage content of each leaven printed by the Ministry of Economic Affairs Central Bureau of Labor Development R Industrial and Consumer Cooperatives 1 Twenty-four four leaven 1 _ Hexadecanol fermentation 1 Hexadecanol 1 Benzoctane fermentation 1 Benzosalkyl alcohol 1 -30 octane fermentation 1 1-3 docane fermentation 1 1-3 decane fermentation Example 6 250 grams of oxidized grams of crude sugar cane were missed. This soap is used in solid-liquid extraction for .A. A. 12 hours. Recrystallization. The purity was 9.16 g. M. Η. 0 to 81.5 C. Table 9 Qualitative and quantitative of AA Table 9: The resulting M.H. component 0 6 3 6 3 0 12 5 0 8 5 5 6 10 10 7 2 18 3 1 7 4 Calcium was added in advance at 1 OOt: melted 1 Thousands of chemical processes were carried out under continuous agitation for 2 hours. 2_propanol was used as a solvent to extract M.Η.Ρ The resulting product was cooled at room temperature and melted with 3.63% M.Η.PA A PAA of heptane The sticky fan is 80. The composition of M.H.P. obtained by this method is listed. The qualitative and fixed composition of PA Α. The percentage content of each leaven is 22. The paper size is applicable to the Chinese National Standard (CNS) A 4 specifications (210 X 297 g *) (please read the precautions on the back and fill in the page) A6 B6 Fifth, the description of the invention () 1 _ Ticosanol 1 _ Twenty-six Alcohol 1 _ Twenty izuan alcohol 1 — Twenty-eight roasted yeast 1 _ Twenty-nine courtyard leaven 1 Thirty-thirane leaven 1 Tridecyl alcohol 1_tridecyl alcohol Example 7 400 g of dilute in 200¾ liters of water was first kept at 1 1 Ot: melted 2 kg of refined sugar cane for 3 hours with continued stirring. Take M.H.P.A.A. for 6 hours in a solid extractor and recrystallize it with. .389g with a purity of 95.10% was obtained. The melting range of the mixture is 8. Table 10 lists the qualitative and quantitative composition of M. obtained by this method. Table 10: Resulting M.H.PA Α. Components 0.6.3.6.4.0.12.4.0.8 4 5 2 18 13 6 9 5 4 9 3 8 0 Add to the pre-cricket. This process uses toluene as the solvent to extract methanol as the solvent for the second time. M.H.P.A.A 1.0 to 8 3 · 0 ID Η · P.A.A. (Please read the notes on the back first Please fill out the matter and buy again) Printed by the Central Ministry of Economic Affairs, quasi-thirsty Beigong Consumer Cooperative Co., Ltd. 7.002.82 23- This paper scale is applicable to China National Oak Quasi (CNS) A 4 specifications (210 X 297 ?, 5). Invention description () A6 B6 (Please read the notes on the back before writing this page >-Installed. Set · Printed by the Central Standards Department of the Ministry of Economic Affairs, Consumer Engineering Cooperative 1-28-Ester 1 Fermentation 1 29-Diastere Fermentation 1 Thirty-Third Alcohol 1-Tridodecane Enzyme 1 Thirty Tetrahydrolase Example 8 5 kg of purified sugar, 0,000 in 1 ml of water, kept for 4 hours. In solid • Η • Ρ • A • A »Using toluene as the solvent degree is 9 2 • 2 0% Μ • Η • Ρ * A • Between c ○ Table 1 1 column * Qualitative and quantitative groups Table 1 1 The obtained Μ • component 1 one-two-tetrakanol 1-two-barkanol 1-two-barcosane alcohol 1-two-barcosane alcohol 1 one-two-barcosane alcohol

The curtain m is treated with potassium hydroxide at 120 V. One-liquid extraction is used for 5 hours. Then, the melt adhesion range of Μ • Η • P • A Μ • Η * P • AA • is in the range of In this way, the obtained ΗΗΡ AA 6 4.54 0.72 13.02 5.31 0.89 was melted and diluted with a thin box at 50. This process was followed by ethanol extraction with continuous stirring. The extract was cooled at room temperature. A. Crystallization. Get 磘 .A. 1 4 9 0 grams. 7 9. 5 and 8 1. 〇Μ. Η. Ρ. A. A qualitative and fixed composition of the percentage of each alcohol containing 霣 0.76 6.58 2.84 6 2.43 I0.71 -24- This paper scale is applicable to a Chinese standard (CNS > A4 specifications (210 X 297 g *)) A6 B6 printed by Wong Wong Consumer Cooperative of the Central Bureau of Economic Development of the Ministry of Economy V. Description of invention () 1 Triacontanol 13.08 1-Tridecanol 5.05 1- Tridecyl alcohol 0.75 Example 9 Two different drug splitting agents were developed with M • H • P • A • A • as active ingredients • The ingredients are listed in Table 1 2 These cracks are i The physical, chemical and physicochemical characteristics of the active ingredients are very sticky and cracked. The active ingredient and the pharmaceutical excipients are mixed in a controlled ratio by the wet dip method to dry, thresh, lubricate and press the tablet A medicine-based Yangschel group splitting agent 1 with Μ • Η • P. AA as preparation 2 (%) (%) Μ • Η • P • A • A • 5 • 0 15. 0 lactose 5 6 0 5 4. 0 Corn starch 1 5 0 10. 0 Ming m 2 5 2. 0 Cross-linked carboxymethyl m Vesuna 5 0 4. 0 Μ Sugar 5 0 4. 0 Talc 2 0 2. 0 Stearic acid m 1 5 1. 0 Cellulose ethoxylate phthalate 0 5 1. 0 Nanocrystalline m Vitamins 7. 5 7. 0 Example 1 0 -25- This paper standard is aa standard (CNS ) A4 specifications (210 X 297 mm) (please read the precautions on the back before filling in this page)--_ _ order. A6 B6 5. Description of the invention () Make male New Zealand rabbit (2-3 kg) Adapted to laboratory conditions for 15 days, randomly divided into 4 experimental groups, a control group (only taking the vehicle) and Sanyu M.Η.PAA treatment group. The latter three components were separately administered by fee tube feeding (1¾ litre / kg) for 5, 50, and 200 mg / kg of M.H.P.A.A. suspended for 4 weeks. Measure the lipid content at baseline (before starting treatment and after 4 weeks of treatment). The oral administration of 5, 50, and 200 mg / kg of M.H.P.A.A. within 30 days was significantly reduced in a manner in which a drug was placed (Wilcoxon P < 0.05). The content of total 88 sterols and low-density protein in serum. In addition, the percentage change in the control group and the treatment group is statistically different (Mann Whitney U, P < 0./05) • See pictures 1-4. In the Yi-S test system, the highest dose of M.H.P.A.A. (200 mg / kg) was used to reduce blood cavity solid fermentation and LDL-C to 5 1-78%, respectively. The HDL-C content was not significantly affected in all four groups (圔 5). Comparing the percentage of triglycerides between the treatment group and the control group, the effect was also obvious (Mann Whitney ϋ, Ρ < 0.05), but no falsehood between the dose and the effect was observed (see circles 6 and 7). Example 1 1 Central Standard of the Ministry of Economic Affairs. M, Printed by the Industrial and Consumer Cooperatives (please read the precautions on the back before filling in the purchase) The male New Zealand rabbits are randomly divided into 4 groups: a slap control group (stomach only Tube feeding method) and the 3-dip group treated with 5 ml / kg M.H.P.A.A., octacosanol and hexacosanol respectively. Blood lipid distribution was measured at baseline and after 30 days of treatment. Μ. Η. Ρ. Α. Α. Significantly reduced total 86 sterols and LDL-C. In addition, Μ. Η. -2 6-This paper scale is applicable to the Chinese National Standard (CNS) A 4 specifications (210 X 297 mm) A6 _ ^ _ B6_ V. Description of invention () PAA treatment of household ghosts Fermentation, LDL-C and triglycerides were significantly lower than the control group. However, there was no statistically significant effect on blood lipid in the two groups treated with octacosanol or hexacosanol. The results are shown in Table 13. Table 13: Shadow depression dosage groups (mg / kg) of PAH, octacosane fermentation and hexacosane fermentation on the serum lipid content (millimoles / liter) of normal western rabbits Total sterols after baseline treatment (please read the precautions on the back before filling the nest page) — — _ Printed by the Central Bureau of Standards of the Ministry of Economic Affairs, Printed by SIC Consumer Co., Ltd. 0 2. 5 2. 3 MHPAA 5 2. 8 1 6 * + octacosanol 5 2 · 7 2. 2 hexacosanol 5 2. 6 2. 4 LDL-C control 0 1. 5 1. 2 M. H. P. A. A. 5 1. 3 0. 6 # + octacosane fermentation 5 1. 4 0. 9 hexacosane fermentation 5 1. 5 1. 0 triglyceride-27- Order · This paper scale is applicable to China National Standards (CNS) A4 specifications (210 X 297 mm) V. Description of invention () A6 B6 ZTE Standard Residence of the Ministry of Economy β: Printed by the Industrial and Consumer Cooperatives 0 0 • 8 0 0 * 8 2 Μ. HP A · A · 5 0 « 7 8 0 • 5 5 Twenty-eight Hospitals leaven 5 0 • 7 7 0 • 7 0 Eicosanol leaven 5 0 • 8 0 0 »7 8 # ρ < 0 .05 Compared with the control group (Ma nn whitney -U test) < 0 .05 compared with baseline (Wile 0 X on) Example 1 2 After 5 weeks of using only prescribed foods • 45 cholesterol and LDL — C values are not adequately controlled with food Outpatients took 5 mg of Η Η • P • A • A • lozenges (each time for lunch and dinner) or ineffective controls for a total of 6 weeks. During this effective treatment period »Maintain the prescribed dietary conditions. At baseline (at the end of the prescribed diet period only) and after 4 and 6 weeks of treatment, the lipid content was determined. Μ • Η summer P .A • A • significantly reduced total blood ligustritol and LDL — C, respectively 16 • 2 3 % And 2 1 • 3 3% The ratio of lintosterol to Η DL — C and the ratio of LDL — C to Η DL — C ft were significantly reduced by 1 1.6 7% and 2 2 »2 8% ( P < 0 • 0 5 »Wilcox ο η test of paired data) 〇In all patients> Glucosamine Alcohol content and LDL-C content are lower than the baseline value after 6 weeks of treatment. The composition of other lipid corpuscles is unknown. The results are listed in Tables 1 4 and 1 5. Table 1 4 Μ • Η • Ρ • A • A • (10 0 g / day> 2 times 9 times each time 5 mg) on the distribution of blood lipid (millimol / liter) in patients with type I hyperlipoproteinemia * 28- ----- ------------ ^ ------- installed ------ ordered ------ ^ first three sides of the note $ item then f this book) this paper The Zhang scale applies the Chinese National Standard (CNS) A4 specifications (210 X 297 mm) A6 B6 Printed by the Central Bureau of Economic Development R Industrial and Consumer Cooperatives η Baseline 6 weeks (X + SD) (X + SD) Total knee strength Alcohol MHPA Α. 22 7.43 + 1.29 6.21 + 1.38 ### Invalidation 23 6.97 + 0.72 6 .7 0 + 0 .75 # LDL-C KHPA A. 22 5.54 + 1.22 4.35 + 1.3 1 # * # Ineffective agent 23 5.07 +0.63 4.97 + 0.67 LDL-C MHPA k. 22 1.03 + 0.26 1.10 + 0.28 Invalid 23 23 1.13 + 0.31 1.02 + 0.28 Triglyceride MHPA A. 22 2.41 + 0.94 1.7 4 + 0.88 Ineffective agent 23 2.03 + 0.64 1.87 + 0.67 VLDL -C MHPA A. 22 1.09 + 0.43 0.79 + 0.40 Ineffective agent 23 0.92 + 0.29 0.85 + 0.31 Number of patients -29- (Please read the notes on the back first (Fill in this page) This paper scale is applicable to the Chinese National Standard (CNS) Grade 4 (210 X 297 " K%> A6 _B6_ printed by the R and Consumer Cooperative Society of the Central Sassafras Bureau of the Ministry of Economic Affairs. 5. Description of the invention ()-* Ρ & lt 0.01; *** Ρ < 〇〇〇〇1, compared with the baseline (Wilcoxon)-a P < 0.05 compared with the ineffective agent, absolute value, Mann Whitney U test. P < 0.001 compared with ineffective agent (Mann Whitney ϋ test). -"" "P < 0. 0 0 0 0 1 compared with the ineffective agent, (Kann Whitney U test). Table 15: MHPAA (10 mg / day, divided into 2 times 5 liang each time) for patients with type I blood lipoprotein Shadow depression after the patient's blood lipid ratio (millimol / liter) η Baseline 6 weeks (X + SD) (X + SD)

LCL-C / HDL-C MHPAA 22 5.71 + 1.82 4. 18 + 1.59 ** Ineffective agent 23 4.92 + 1.85 5.30 + 1.79 Aminosterol / HDL-C MHPAA 22 7.65 + 2.18 5.94 + 1.81 * " Ineffective agent 23 6.69 +2.21 7.06 + 2.05-«Ρ <0.05;## P < 0.01, compared with baseline (Wilcoxon) -a Ρ &0.05; compared with ineffective agent, absolute value, Mann Whitney ϋ test. Ρ < 0.05 compared with ineffective agents (Mann Whitney U test). 1. ‘’ ’p < 〇.01 compared with the ineffective agent (Mann Whitney II test). Example 1 3 A group of patients with type Ⅱ hyperlipoproteinemia should only consume at 8 weeks -3 0-This paper scale is applicable to the Chinese a standard (CNS) A4 specification (210 X 297 mm) --- --------------_------ installed ------ ordered (please read the precautions first and then fill in the purchase) A6 B6 V. Invention description ( ) After printing the diet (baseline) of the Ronggong Consumer Cooperative of the Central Bureau of Samples of the Ministry of Economic Affairs, take a lozenge containing 15 mg of the composition. Measure the blood lipid distribution at the baseline and after 8 weeks of treatment. The main results are summarized in the table. 1 6 Φ 〇 The preparations containing Μ • Η. Ρ • A. A • significantly reduced the total amount of blood fermented by 16 4 4%, and the LDL — C decreased by 2 3 5 1% (see FIG. 8) 0 Η DL-C increased by 6 • 4 0% »while triglycerides and low-density lipoprotein linsterol (VLDL — C) decreased by 7 • 8 0% and 1 0 • 8 3%» but these changes were statistically Nothing. Table 17 lists the ratio of LDC -C to Η DL — C and the ratio of knee solid yeast to Η DL — C Subject to chemical, they significantly reduced 2 9 »0 7% and 2 3 • 7 2% 〇 Table 16 = Μ • Η. Ρ • A. A • For patients with type I blood lipid hyperlipoproteinemia patients with blood sputum Distribution and parameters of lipoprotein color depression η Baseline η 6 weeks (X + SD) (X + SD) Knee solid yeast 25 7 .84 + 1. 14 25 6 .50 + 1. 2 1 LDL — C 17 5 .86 + 1 · 11 18 4 .33 + 1. 32 4 # Η DL — C 19 1 .03 + 0. 44 20 1 .21 + 0. 46 triglycerides 19 2 .3 0 + 1. 42 20 2 .14 +1. 06 VLDL — C 19 1 .05 + 0. 64 20 0 .97 + 0. 48 # «Ρ < 0. 01 < 〇. 0001 (Wile 0 X on test) Table 1 7 ·· Μ. Η • P. A * A • Effects on the ratio of LDL — C / Η DL -C and amine-solid enzyme / Η DL -C in patients with type I hyperlipoprotein -31- (please read note 4m on the back first (Enter this page again) This paper standard is universal Chinese National Standard (CNS) A 4 specifications (210 X 297 mm) 299230 A 6 __B6_ V. Description of invention () (please read note f on the back and then fill in this page) Parameter η Baseline η 8 Sir (X + SD) LDL-C / HDL-C 17 6.34 + 2.79 18 3.82 + 1.55 * «Holsterol / HDL-C 19 8.83 + 3.49 20 6. 07 + 2. 17 # * * * Ρ < 0. 0 1 (If i 1 c ο X ο η test) Example 1 4 First, study Η . The role of PA Α. And its effect on peptone diphosphate (ADP) and plaque-induced rat platelet aggregation «. A group of male Sprague-Dae ley Big E weighing 2 50 to 350 grams were randomly divided into two experimental groups. A suspension of M.H.P.A.A. in Arab mash mono-water vehicle was orally administered with a fee-feeding tube for 4 weeks. One of the two groups was a control group that only took the vehicle, and the other group was treated with M.H.P.A.A. (25¾ g / kg). For identification of platelet aggregation, rats were anesthetized in ether atmosphere. Open the abdomen and draw 5 ml of blood from the vena cava, mixed with 3.8% grade Jibu Central Kneading Zhunju Employee Consumer Cooperative Printed Sodium Prongate (mixed with 9 volumes of blood and 1 volume of citric acid). Carry the blood into the heart to obtain platelet-rich plasma (PRP). The PRP solution was centrifuged at 330xg for 15 minutes to obtain platelet-containing plasma (P PP) ^ This platelet was induced to aggregate with adenosine diphosphate and plaque, and was measured using a Payton concentration meter as described in the literature (McGregor 1., Horanzain R. and Renaud S .; 1980; Effect of edible linoleic acid on platelet function in rats; Thraabosis Res. 20.499). The nonparametric Hann-Whitney U test was used to compare the results between the treatment group and the control group. Rats treated with Μ.Η.PAA of 25 € g / kg for 4 weeks-32- This paper scale is applicable to the Chinese National Standard (CNS) A4 specifications (210 X 297 mm). A6 _ ^ _ B6_ printed by the consumer cooperative. 5. Description of the invention (). When taking the next highest dose of adenosine didiscate and erogen, it significantly inhibited the aggregation of extraplatelets (see pictures 9 and 10). The fact that M. H. P. A. A. was surrounded by anti-crack adenosine diphosphate and sleep platelet-induced platelet aggregation in rats showed that M. H. P. A. A. functions as an anti-platelet drug. Example 15 In order to examine the effect of M.H.P.A.A. on platelet aggregation in vitro of rats, the time course of its antiplatelet aggregation action was studied. To this end, will the weight of 2 5 0 to 3 50 grams of two genders 5? ^ 118

Da vi ley rats were divided into four groups: the experimental group treated with a single dose of 25, 50, and 200 ¾ g / kg M, H.P. In addition, after taking 200 μg / kg of 1! For 2, 6 and 24 hours, the effect on platelet aggregation was studied. M.H.P.A.A. was prepared by the method described in Example 14, and was administered orally in a single dose 2 hours before the experiment. Control animals took the same crocodile carrier. All animals were fasted, but they were free to drink water 20 hours before the experiment. All animals were anesthetized with ether, blood was drawn from the vena cava and concomitant with 3.8% sodium citrate (each 9 snakeheads called blood plus 1 snakehead anticoagulant). The blood was centrifuged at 250 s for 10 minutes to obtain platelet-rich plasma (PRP). Once PRP is separated, the remaining portion is centrifuged at 1,300 g for 15 minutes to obtain platelet-free plasma (P PP). Quantitative determination of platelet aggregation degree by turbidity method (Born, G., 1 9 6 2; platelet aggregation and decomposition caused by adenosine diacid; Nature -33- This paper scale is applicable to China National Standard (CNS> A4 specifications (210 X 297 Gong «·) (Please read the precautions on the back before filling out this page) • Installed. Ordered · Printed by the Central Standards Bureau of the Ministry of Economic Affairs R & Consumer Cooperative A6 ___B6_ V. Description of invention () (London) 1 9 4, 9 2 7-9 2 9). Calibrate the instrument to 0% for RPP and 100% for PPP, and then determine the platelet aggregation degree. Record the aggregation curve for 5 minutes. Use a large percentage of aggregation ( %). The Wann-Whitney U test (P < < 0.05) was used for comparison among the groups. Taking M.H. PAA (50 and 200 g / kg) 2 hours before the blood sampling inhibited the adenosine disc. Acid-induced platelet aggregation, while the lower dose (25 mg / kg) did not significantly change the response to adenosine diacid (see Figure 11). The highest dose of L. .A. (200 mg / kg) to study the time course of the antiplatelet effect. Although platelet aggregation was significantly inhibited after 2 hours , But this inhibitory effect became less obvious after 6 hours (P = 0.06), and statistically meaningful results were not available after 24 hours (see circle 12). The results show that after blood collection 2 Hours ago, rats were given oral docosane fermentation. In rats treated with 50 and 200 ¾ g / kg of M.H.PAA, PRP treated with a dose-dependent pathway inhibited adenosine disulfate-induced Platelet aggregation. Μ.Η.PA A · inhibition of adenosine dipound acid-induced aggregation is reversible, because after treatment with it at a dose of 200 mg / kg for 6 hours, #platelet aggregation inhibition has been Not very obvious, but after 24 hours of treatment, the loss of effect was observed, indicating that M. HPAA does not cause permanent cell changes. Example 16 The effect of M. Η. PAA on platelet aggregation in rat venous veins was investigated Yuhe's impact on the mortality rate induced by mice. Will weigh 250 to -34- (please read the notes on the back first and then fill in the * page)-Pack · Order · < · This paper standard is universal Chinese national standard ( CNS) A 4 specifications (210 X 297 ¾¾) Ministry of Economic Affairs, Central Ministry of Housing and Industry, β-consumer cooperative System A6 ____B6_ V. Description of the invention () 300g Sprague Dawley male rats and 5 7BL6 female mice weighing 20 to 25g are randomly divided into several experimental groups. Μ. Η.P.A • A. according to Prepared as described in Example 14, acetoacetate (ASA) shellfish is dissolved in 5% NaCOs. The drug was taken orally by tube feeding 12 hours before identification. Animals were fasted 16 hours before oral medication. Male rats weigh 1 ml / 100 grams, and female rats weigh 0.5 ml / 20 grams.

Take the medicine, according to the animal, take a considerable crocodile load I. The Sijian experimental group was used in the study of intravenous platelet aggregation in Dachan: ⑴ control group, ⑵⑶⑷, respectively, 5, 10 and 20¾ g / kg of M.H.P.A.A. Animals were anesthetized with pentobarbital (30_40 mg / kg). Before injecting 30 mg / kg of mash into the penile vein and after 90 seconds, a cannula was taken into the common artery to take a blood sample. "Including 0.73 g / ml indomethacin and 19 mg / ml Collect 900 olive liters of blood in a plastic tube of 100 litres of EDTA. Take a part to measure the platelet S level in each sample by counting with an optical microscope. The blood was then centrifuged, and the plasma malondialdehyde (MDA) concentration was quantitatively determined by the thiobarbituric acid method (Sat Qh, 1 9 78; new colorimetric method for the determination of blood lipid pergasification in cerebrovascular disorders; Clin Chim. Acta 90 , 34-43). The changes in platelet count and plasma MDA concentration after collagen injection are expressed as a percentage of the baseline value. The difference between the control group and the treatment group was confirmed by the "41111-W b i t n e y 1] test. In order to study the collagen-induced rat mortality, the experiments were divided into the following groups: 1) Control group: Dongxu only took the carrier, but the collagen injection method was used -35- This paper scale is applicable to the Chinese National Standard (CNS) A 4 Specifications (210 X 297 g *) < Please read the note 4m- item on the back first and then fill in this page)-Packing. Order · A6 __B6_ Printed by the Ministry of Economic Affairs, Central Bureau of Industry and Economic Cooperation, V. Description of invention ( ) Induced death; 2) Pretreated animals with 360 mg / kg of M.H. PAA 2 hours before the injection of Kojihara; 3) 360 mg / 1, 4, 8 and 24 hours before induced death Kg body weight of M.H. PAA pre-treated animals; 4) 2 hours before the test, the animals were pretreated with 180 mg / kg body weight and M.H. PA A. and 50¾ g / kg body weight of ASA. Preparation of type II acid-soluble calf leather collagen as described in the literature (Kieiura Y., Kaube T. and Watanabe K., 1985; Celostagel's effects on platelet aggregation and experimental blood tests W; ArzneiB Forsch Drug Res. 35, 114 -1148), with a final leaching of 2.5 5g / ml. From the injection through the posterior orbital blood vessel, the dose is 0.1 ml / 20 g of pulp weight. One dose caused 60% to 100% mortality of the control animal. The comparison of the percentage of death between the control animals and the treated animals was performed using the Fixcher fit probability test. Μ.Η.P.A.A. obviously inhibited the decrease of circulating platelet count induced by collagen and the simultaneous increase of plasma MDA concentration (see Figure 13). M.H.P.A.A of 360¾ g / kg bone weight greatly reduces the mortality rate induced by the wishing (see _1 4). The lethal protection effect on gums was observed when this dose was taken 1 and 4 hours before the test, but it was not significant when taken 8 hours before the test (see Figure 15). Μ. Η. Ρ. A. A. (180 mg / kg body weight) and-3 6-(please read the precautions on the back page first)-Binding-Order., Quan · This paper size is suitable for a Chinese company Standard (CNS) A4 specification (210 X 297 g *) A6 _B6_ produced by the Beigong Consumer Cooperation of the Central Bureau of Standards of the Ministry of Economic Affairs V. Description of invention () The combined application of ASA (50¾ g / kg weight) also caused warming The lethality was statistically significantly reduced, but when both were taken alone, there was no effect (see circle 16). The M.H.P.A.A. Erzhi and the eight-thirty-six-quantity that were not effective when the badger was taken, had the protective effect of Mingzhi when used together, thus indicating that the antithrombotic effects of M.H.P.A.A. and ASA have a synergistic effect. Example 17 In order to analyze the effect of Μ.Η.PAA on rat cerebral embolism, Sprague Dawley male plaques weighing 2 9 0 to 3 30 grams were divided into the following experimental groups: 1) Positive control group: not ligated Of rats only took the carrier by the method of tube feeding; 2) positive control group: the ligated rats also took the carrier by the method of tube feeding; 3) and 4): the ligated rats took the same route separately. .HPAA (the treatment groups with different weights of 5 and 25 mg / kg mandarin weight are taken 4 times a day). The last group is as usual in the shape of the chessboard. It is taken 12 hours before the ligation and 8 and 24 hours after the ligation. Induce ischemia of the brain, anesthetize gently, and reduce the blood volume by ligating the neck and moving it. Inject the sodium nitroprusside (0.8 mg / 250 g bone weight) subcutaneously immediately Arterial hypotension E. Remove the cervical urea head after 60 minutes, observe the animal for 72 hours, and then kill it. Quickly remove the brain and place it in an oven at 80C for 24 hours. Determine the wet weight and dry weight to determine the water content (hydrazone) ), Using the following formula: -37- This paper scale is applicable to China National Standard (CNS) A4 specifications ( 210 X 297 mm) ---------------- (-------- install ------ order ----- · («(please first Η Read the precautions on the back and then fill out this page> A6 B6 After the Ministry of Economy, go to the standard room RX consumer cooperative print «A non-parametric analysis is used. Taking 2 5 A every day can significantly reduce the dosage of one dose and also reduce it. The two reductions in death are not as obvious as the cerebral ischemia of 5 mg / kg of snakehead rats. In the treated animals, but the effects of reduction are not shown in Table 18 ·· Μ. Η. Fifth, the description of the invention (漉 重One dry weight edema = wet weight

The Mann-Whitney U test statistically scored the results. M.H.P.A. mild cerebral edema (P < < 0. 0.5) at 0 mg / kg body weight. This mortality rate and the percentage of animals with edema, although otherwise to a significant level. These findings indicate that the protective effect of M.H.P.A.A. taking 2 on experimentally-induced moths is greatly reduced, because the brain edema is greatly reduced, showing that the percentage of brain edema and face mark has also been reduced to a significant level (see Table 18). PAA on large and evoked cerebral ischemia Please read the notes on the back before filling the nest. Percentage of the agent placed in the experimental group (mg / kg) Edema dead animal (_) control 0 79.3 +/- 0.39---(+) control 0 80. 1 + /- 0.82 35 54.5 M. H. P. A. A. 5 80 .0 + / -0. 9 1 40 33.3 MHPAA 25 79. 5 + /-0 .49 # 28 7. 6 (_) Control: negative control; (+) Control: Positive control: X is significantly different from the positive control; P < < 0.05 (Mann-Whitney U-38- This paper scale is applicable to China National Standards (CNS) A 4 specifications (210 X 297 mm) A6 _ B6_ V. Description of the invention () test). Example 18 To study the synergistic effect of Μ.Η.PAA and aspirin on induced cerebral ischemia in rats, it will weigh 250 to 300 Gram male Sp 1: ague D a η 1 ey mice are divided into 5 groups 1) Negative control (unligated mice); 2) Positive control (ligated animals that only take the vehicle); 3) Oral administration by tube feeding 25 Mg / kg of M.H.PA A.A. animals; 4) Orally dissolved in 5% sulfonate Animals with 30 mg / kg body weight of A S A in acid radon solution; 5) Oral ASA (30 mg / kg body weight) + M.H.P.A.A. (25 mg / kg body weight) rats. Take the medicine 2 hours before the experiment. To induce ischemia, the animals were lightly anesthetized with ether, and the urea well was isolated and ligated. Then subcutaneously inject sodium nitroprusside (0.8 mg / 250 g fishy weight> Dicheng hypotension. The Department of Economics and Development of the Central Co., Ltd. of the Ministry of Economic Affairs of the Ministry of Economic Affairs (Please read "Precautions on the back and then write I") After 60 minutes, the arterial heads were removed, and the animals were observed to kill them by β for 24 hours. The brains were immediately removed and placed in an oven at 801C for 24 hours to determine the water content. The results were analyzed using non-parametric Mann-Whitney ϋ test. The dosage of M.H.PA Α. And aspirin were not able to relieve cerebral ischemia when they were taken in separate animals. However, when they were taken together, they obtained obvious protective effects (Ρ < < 0.01. ) (See picture 17). These results confirm that the anti-locality in Μ.Η.PA Α. And ASA-39- This paper scale is applicable to the national standard (CNS) A 4 specifications (210 X 297 mm> 299230 A6 B6 V. Description of the invention () There is a synergistic effect between the ischemic effects. Example 1 9 Mongolian gerbils of two genders are used (weight 6 0 _ 8 0 g) »Make it suitable for sleeping in the laboratory for a week 〇Suspension in T «Feen- '20 by gastric tube feeding Μ »Η • Ρ • A in Aqueous Solution Carriers A and A • 〇 Randomly divide these animals into the following groups • 1) Restricted control (ligated animals» only take vehicle) • 2) Μ • Η • Ρ • A • A • (50 mg / kg weight) > 3) Μ • Η • Ρ • A • A • (300 mg / kg weight) 〇All therapeutic drugs are 2 hours before inducing cerebral ischemia Taking 〇 will be exposed in the total carotid artery> Double ligation under ether anesthesia with surgery P Observe the behavior of each animal 2 4 hours t Record the clinical symptoms of cerebral ischemia »For example, circle» Recurrent spasms and epilepsy etc. 0 Simultaneously Record the mortality rate 0. Use the Fi s C he Γ positive and negative test method to statistically compare the mortality rate of each group and the frequency of bed symptoms. The results show that this treatment reduces clinical symptoms and greatly reduces the mortality rate (see circle 1 8 ) 〇 It is well known that about 60% of Xinggu gerbils develop neuropathic defects after ligation of the neck and urea. For example, the circulatory ρ is and periodic spasm. There are some symptoms with about 2/3 of the animal ’s skull base and Cervical urea% The connection between the system and the urea is not complete or there is no 銆. In addition, almost 80% of the display is printed by the Ministry of Economy Central Standards Bureau Code Industry Consumer Cooperative (please read the precautions on the back before filling in this purchase ) Animals with clinical symptoms die within 7 2 hours after ligation. Because it is difficult to determine the degree of vine weight formed by cerebral infarction in all brain regions, and the mortality rate is easy to determine quantitatively, this parameter is usually used to evaluate it as -40- This paper scale is applicable to the Chinese National Standard (CNS) A 4 specification (210 X 297 mm) A6 __B6_ printed by R Industry and Consumer Cooperative, Central Bureau of Standards, Ministry of Economic Affairs V. Description of invention () Ischemic drugs. Our results show that M.H.P.A.A. (200 mg / kg body weight) has a significant protective effect on cerebral ischemia caused by ligating the common carotid artery on one side of the Mongolian gerbil. Therefore, it shows that M.Η.Ρ · Α.Α. Can be used to prevent the occurrence of cerebral ischemia. Example 20 The shadow of various drug-induced Fischer ulcers of M.H.P.A.A. Temple was studied. Sprague Dawley rats of two genders weighing 200 to 220 grams were used. Allow animals to sleep for a week in laboratory conditions, with water and food free. After fasting for 24 hours, the rats were randomly divided into two tilting spring test groups. The first group was injected intraperitoneally with M.H.P.A.A. (25 mg / kg g weight) suspended in Tween 20 / water vehicle, and the second group (control group) received only the same volume of vehicle. In each case, the control group and the treatment group were tested with different types of drugs to induce different ulcers (two groups for each type of ulcer): A) S induced by C 4 8 8 0 (Sigaa) experiment ulcer. The experimental procedure is similar to that described by Awouters F ·, Nesiegeens CJE and Jansken PAJ (1985: Pharmacological analysis of the rat mast cell 5-HT fee injury test and the effect of haloperidone; Drug. Div. Res. 5, 303-312) ^ To this end, 10 mg / kg β-benzylhydroxylamine was injected subcutaneously, and C4880 was injected intravenously 30 minutes later. After 4 hours of application of C4880, Dongjun was killed, and he was quickly taken out. S Daqi was cut along the length and washed with steamed preserved water. Then, burst the gastric mucosa and measure the damaged area with a magnifying glass. Use the results to show the loss-4 1- This paper scale is applicable to the Chinese National Standard (CNS) A 4 specifications (210 X 297 g * * -------------------- ---- Installed ^ ------ Ordered ----- "Line (please read the notes on the back first and then fill in this page) A6 _______B6_ printed by Central Standard Housing and Industrial and Consumer Cooperative of the Ministry of Economic Affairs 5. Invention Explanation () The percentage of the injured area is expressed. In the previous method, the pre-medication (M. Η. PA A. or 艤) was taken 30 minutes before the injection of biphenylhydroxylamine. B) Bacteria-induced ulcer. The test procedure was carried out as described by Zengil H, Onik E, Erean TS and TS and Tarker RK (1987: ilopnost and UK 38485 to protect against mucosal damage caused by various stimulants; Prostaglandins Leukotrienes and Medicine, 30, 61-67 ). For this purpose, rats were orally administered 40% ethanol (1 l / each mouse) by gastric gavage 1 hour after administration of Μ.Η.Ρ.Α.A. or vehicle. After 2 hours, the rats were killed, and the night ulcer was quantitatively determined as described above. C) ASA-induced S ulcers: tested according to the method of the same author cited in the previous section. After 1 hour of treatment with M.H.P.A.A. or Zyzae, rats were orally administered ASA (100¾ g / 1000 g snakehead weight). After 2 hours, the rats were killed, and the cancer was determined as described above. The non-parametric Uann-Whitney U test was used to compare the control group with the M.H.P.A.A. treatment group. Intraperitoneal administration of M.H.P.A.A. (25 mg / kilogram; body weight) inhibited gastric ulcers induced by C4880, ethyl yeast and ASA (see 圔 19). In addition, as can be seen from Table 19, oral administration of M.H.P, A.A. not only reduced TxBz, but also increased Pg 12, thereby greatly reducing the ratio of TxB2 to Pg IZ. -42- This paper scale is applicable to China National Standard (CNS> τ 4 specifications (210 X 297 mm) ---------------- 一 -------- 装------ Subscribe ----- ^ Line (please read the notes on the back before writing this page) A6 B6 printed by the Central Standard of the Ministry of Economy, R, R, and Consumer Cooperatives V. Invention description () Table 19: Μ. Η · PAA and ASA on mouse blood TxBz content and 6 ketone PsF 1 a τ X B2 6 ketone PgFla Tx B2 (ng / ¾ liter) (ng / ml) 6 ketone PgFla control 286+ 16.7 1.65 + 0.26 173

ASA (50 mg 36 · 3 + 13.3 ** (a) 1. 12 + 0.41 46.5 / kg) M. H. P · A. A. (180¾ g 182 + 3 1 .9M (b) 3.91 + 0.4 * 32.4 / kg) Μ. Η. P. A. A. + ASA 9.25 + 5.4 * »(c) 1.57 + 0.16 5.8 # P < 0, 0 5; * * P < 0. 0 1; a = b = c (M a η n W hithey U test) The inhibition of TxBz content and the increase of Pg 12 caused by Μ.Η.PAA can relieve the protective effect of this mixture on Erkui. Therefore, when M.H.P.A.A. and ASA were used at the same time, a large ratio of TxBz to Pg 12 was observed; A: decreased. In addition, this mechanism may also explain the effect of alcohol mixtures on other ulcer-induced Fischer ulcers. Example 2 1 For 45 outpatients with type I hyperlipoproteins from two genders ranging from 25 to 70 years old, taking M.H.PA Α. Or invalid control tablets 6 once a day under double-blind conditions Zhou (Treatment of patients every day service-43- This paper scale is applicable to China's a standard (CNS) A4 specifications (210 X 297 public goods) (please read the notes on the back and then write down I) • Install. Order · Printed goods Α6 Β6 by the R-Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs V. Description of invention () 5 mg Μ.Η.PAA). The following parameters were studied before and after treatment: bleeding time, platelet count, prothrombin time, antithrombin K activity, hemolysis time, plasma globulin, ganglioside diphosphate-induced platelet aggregation, and one-propane di Aldehyde (MDA) Australia. Table 20 summarizes the data. These data indicate that none of the parameters related to the coagulation process are affected, and there is a significant difference between the groups induced by platelet aggregation induced by ganglioside diphosphate. In addition, an insignificant reduction in malondialdehyde was also observed (P = 0.058). Table 20 ·· M.H. Effect of PAA treatment on blood coagulation and platelet aggregation in patients with hyperlipoprotein type I Analysis time Ineffective control agent MHPAA (5 mg / day) Bleeding time 0 2, 4 7 "+ /-1 '2 S ”2,31” + / -1,24 ”6 weeks 2,10 " + /-.1,34” 1' 08 " +/- 1,06 " Platelet count 0 201.23 + /-29.98 1 98 . 1 3 + /-3 9. 48 S weeks 188.55 + / -35. 99 175.33 +/- 40.87 prothrombin time 0 13.67 +/- 1.80 14.43 +/- 4.18 S weeks 13.40 +/- 1.10 13. 69 + /-2. 25 pro-ferritin 0 2.64 +/- 0.46 2.84 +/- 0.54 6 weeks 2.81 +/- 0.52 2.92 +/- 0.44 antithrombin I activity 0 79.95 +/- 7.50 82.86 + /-1 1 . 9 7 6 weeks 91.78 + / · 9.69 9 3. 6 7 + /-14. 6 2 Hemolysis time 0 247. 27 + /-3 0. 10 230.43 +/- 48.19 -44- General Chinese national standard for clothing and paper China (CNS) A 4 specifications (210 X 297 public goods> ---------------- (-------- install 丨 ----- order-- --- (Bing (please read the notes first and then ^^ this I) V. Description of the invention (Plasma euglobulin adenosine diphosphate malondialdehyde a P = 0.058 A6 B6 δweek 248.64 +/- 55.72 0 3 5.79 + /-18.18 6 weeks 47.59 + Λ21.29 0 48.98 +/- 16-28 6 weeks 56.97 +/- 24.77 0 2.99 +/- 1.75 6 weeks 2.79 +/- 1.28 228.48 + / -45. 39 3 6. 9 3 + /-2 0. 9 3 30 · 98 + /-24 '19 52.27 +/- 24.26 27.45 +/- 24.81 »# 2.45 +/- 2.31 1.76 +/- 1.67 Central Department Quasi-Feng β: Printed by the Industrial and Consumer Cooperative Society + p < 0.05 + + p < 0. 0 1 (W a η n W hitney U test) Example 2 2 Oral or intraperitoneal administration of Μ.Η.PAA significantly enhanced male Sexual function of rats. For example, male rats are randomly divided into 3 tilt experimental groups and adapted to the experiment for a week. Before mating, the mating activity with estrogens receiving estrogen was measured to ensure randomized distribution of treatment. Once confirmed, the rats were orally administered M.H.P.A.A. or vehicle for 10 weeks by gavage, and the mating activity was recorded after treatment (see Table 21). Table 21: Μ. Η. PAA on the number of rats in the color-can group of sexual function (for SD) Percentage of rats showing the following behavior (%) Climbing up to mating erection Climbing up to mating erection control 8 + 14 8+ 13 50 66 MHPAΑ. 45 This paper scale is applicable to China National Standard (CNS) A 4 specifications (210 X 297 mm > ---------------- (----- --- installed ------ order ----- (f < please read the note $ item on the back and then this page) A6 _B6_ V. Description of invention () 75 92 # 21 + 21 # 22 + 21 : 75 Μ. Η 24 + 19 = »3 7 + 44 # * 83 50 23 + 11 * 23 + 10 * ## 100 Ministry of Economic Affairs Central Standard Pan Weng Wong Consumer Cooperatives Cooperative« 100 * This table lists the climb The average value of mating and penile erection + the deviation of the pinching and the percentage of moving trees showing the two behaviors. The average value of each group was compared using the Mann Whitney U test, and the Fischer ’s probability of coincidence test was used to compare each. The frequency of these behaviors. Sexual function was recorded after 6 weeks of treatment. No significant differences were found between the groups, thus indicating that the enhancement of male sexual function observed during the effective treatment was associated with the drug. However, no return was observed Shrinkage effect. These The results show that the enhancement of sexual function caused by Μ.Η.PAA is reversible after the elimination period. Example 23 3 Study the influence of Μ.Η.PAA on the sexual behavior of male monkeys (Mice monkeys, Ursidae). The animals were randomly divided into the following groups ... A single-control group and a 2-dip group treated orally with 2.5 and 25 gram / kg weight M.H.P.AA, respectively. Table 22 lists the data. Table 22: M.H.PAA's effect on the sexual behavior of baboon monkeys during mating and the content of serum ketone (S + SD) group hormonone content-4 6-p <0.05; *** ρ < 〇.〇 01 (Compare between groups) < Please note the HiMe first, then fill out the purchase. Order-This paper scale is applicable to the Chinese National Standard (CNS) A 4 specifications (210 X 297 g *) A6 B6 V. Description of the invention () (Mg / kg) Number of erections 2 + 1 MHPAA2.5 12 + 10 MHPAA25 11+ 7 Number of masturbators 2 + 1 10 + 9 7 + 5 (millimol / l) 19.25 + 6.98 22.00 + 2.44 16.58 ^ 4.44 Printed by «P <0.05; R &C; R &C; Cooperative Society, Central Bureau of Standards, Ministry of Economic Affairs; comparison with control group (Hann Whitney ϋ test) The results show that Μ.Η.PA Α. Is significant The male sexual activity of the controlled male monkey was enhanced, because the number of penile erections and masturbation increased significantly compared with the control group. However, there was no significant difference between the treatment group and the control group in the content of blood peptide. This example illustrates that taking these formulations enhances the sexual function of the treated animals, while the Yi Yi effect is not related to the androgen levels found in monkeys. The rest of the monkey's general behavior is unaffected. This indicates that the stimulating effect of M.H.P.A.A. is mainly not on the medullary nerve system but on the peripheral effector. Considering the effect of Μ.Η.P.A.Α. on the ratio of ΤχΑ2 to Pgl2, it cannot be ruled out that the release of nitric oxide (NO) stimulates the penis corpus cavernosum as the mechanism causing this effect. Example 24 As described above, M.H.P acts. Since octacosanol is a M component, the effect of octacosanol and M on the sexual behaviors of males in large rice A.A. is the major group that stimulates the sex of males m.P.A • A • .P .A • A »Each white adapts the male and female Westar rats to 2 weeks. Divide the female mouse m by 1 and divide it into 〇 for progress — 80 hours subcutaneous injection 0 5 This paper size is suitable for China National Standard (CNS) A 4 specifications (210 X 297 mm) ---------------- (------- installed ------ ordered --- -(Ball (please read the precautions on the back first and then fill out this page> A6 ___ ^ __ B6_ printed by the Ronggong Consumer Cooperative of the Ministry of Economic Affairs of the Ministry of Economic Affairs. V. Description of invention () mg / kg plaque weight benzoic acid Estradiol ester, 5-8 hours before injection of sulfonamide. Suspended M.H. PAA in Tween 20 water and injected intraperitoneally for 3 weeks. Octadecanol was prepared and administered in a similar manner. Control animals only Administration of the carrier. The animals were randomly divided into three groups: ⑴ control group, ⑵M. Η.PAA group (1.54 mg / kg body weight) and ⑶ octacosanol group (1 mg / kg body weight). Considering The relative dose of octadecyl alcohol in the temperature compound, the above doses ensure that the dose of octacosanol is the same in the two groups treated. At the baseline (to ensure that the sexual function of each group is sufficiently randomized) and Observe the mating activity after 3 weeks of treatment. Record 90 minutes of erection and climbing mating behaviors between the gestated female and the excited penis. Mann Whiteny U test method was used to compare each group. At the baseline, the sex of all groups The function is similar, but after 3 weeks of treatment, the number of erections and climbing matings in the two groups treated is significantly higher than for the group. On the other hand, the number of climbing matings and erections in the Μ.Η.PA Α. Group Much higher than in the octacosane yeast group (see Table 23). These results are consistent with previous results showing that the enzyme mixture stimulated sexual behavior in male rats, but it has shown the octacosanol-induced stimulation However, the sexual behavior of the alcohol mixture treatment group is significantly higher than that of the octacosanol group. It shows that the stimulating effect of the alcohol mixture is incompatible with the presence of octacosanol, but the presence of other alcohols in the mixture is ordered Adjust the pair in some way Functional stimulation. Table 23: Μ.Η.PA Α. And octacosanol on male rats-4 8 _ ---------------- 一 --- ---- Installed ------ Ordered ------- (please read the $ item on the back and then fill in this page) This paper size is applicable to the BS family standard (CNS) A 4 regulation _ pile (210 X 297 > A6 B6 V. Description of invention () Shadow depression group of sexual behavior

X + SD vs. MHPAA octacosanol climb up to mating 44 + 23 175 + 87 * # 81 + 40 * erection 40 + 19 174 + 87 # * 76 + 37 (please read the notes on the back before filling this page) Printed by the Beigong Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs-49- This paper scale is applicable to the Chinese National Standard (CNS) A 4 specifications (210 X 297 g *). The A7 B7 1 sterol is printed by the Consumer Cooperative of the Ministry of Economic Affairs The serum cholesterol content of rabbits \ P < 0.05 (Mann Whitney U test-I. A. The effect of serum LDL-C content in rabbits with normal blood cholesterol), where * is P < 0.05 (Mann Whitney U test). Picture 3: The effect of MHPAA on the serum sterol change (%) in rabbits with normal blood plasma sterols, where >: < is P < 0.05 (Mann Whitney U test). Figure 4: MHPAA on blood cholesterol The effect of normal rabbit serum LDL-C changes (%), where * is P < 0.05 (Mann Whitney U test). Figure 5: The effect of MHPAA on the serum LDL-C content of rabbits with normal blood cholesterol. Figure 6: The effect of MHPAA on the serum triglyceride of rabbits with normal blood cholesterol.

Figure 7: Effect of M.H.P.A.A. on serum triglyceride changes in rabbits with normal blood cholesterol, where * is P < 0.05 (Mann Whitney U test). Figure 8: The effect of M.H.P.A.A. on the distribution of blood lipids in patients with hyperlipoproteinemia type ϋ. Figure 9: Rat adenosine diphosphate-induced blood after taking Μ.Η.Ρ.Α.Α. for one month -5 1- This paper size is applicable to the Chinese National Standard (CNS) Α4 specification (210X 297 mm)

Hi______ 丁 ^ nn nn av ^^ i — ^ ϋ I ί «(please read the precautions on the back before filling in this page) 299230 ΑΊ Β7 V. Description of invention () Small board gathering, where * is p < < 0.05 (Mann Whitney U test); 15 cm 100% light transmittance. Figure 10: Platelet aggregation induced by M.H.P.A.A. for one month in rats, where * is P < 0.05 (Mann Whitney U test); 15 cm 100% light transmittance. Figure 11: Η · Η, Ρ.Α · Α. Platelet aggregation induced by adenosine diphosphate in rat platelet-rich plasma, where * is Ρ < < 0.05 (M a η η W hit η ey U test). _12: The effect of M.H.P.A.A. on platelet aggregation induced by adenosine diphosphate with a turbidity of 2 mols / liter, where * is P < < 0.01. Figure 13: H.H.P.A.A.'s effect on rat platelet aggregation in vein, where * is P < <0.05; «* is p < < 0.01 (Mann Whitney U test). Figure 14: M.H.P.A.A. on collagen-induced mortality of C57BLL6 mice, where ** is P < < 0.01 (Mann Whitney U test). Figure 15: Effect of M.H.P.A.A. on collagen-induced mortality in C57BL6 mice, where * is P < 0.05 (M a η n W h i t n e y U test). Printed by the Employee Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs (please read the precautions on the back before filling out this page) Figure 16: M.H.P.A.A. and ASA mixed with ASA on collagen-induced mouse mortality Impact, where ** is P < < 0.01 (Fisher positive probability test). Figure 17: Synergy of M.H.P.A.A. and ASA on cerebral ischemia in rats, where P < < 0.01 (Mann Whitney U test). Figure 18: The effect of MHPAA on the induced cerebral infarction in Mongolian gerbils-5 2- This paper scale is applicable to the Chinese National Standard (CNS) A4 specifications (210X 297 mm) A7 B7 V. Description of invention (), where M is P < < 0.05 (Mann Whitney U test). The picture shows the alluring alcohol of Yu Ying 1 (please read the precautions on the back before filling in this page) 丄 '-° Printed by the Beigong Consumer Cooperative of the Central Standards Bureau of the Ministry of Economy. (CNS) Α4 specification (210X297mm)

Claims (1)

Beigong Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs of the People's Republic of China 腈 六. Application for patent scope 1. A pharmaceutical composition used for the treatment of hyperplasia of blood stasis, excessive aggregation of platelets, ischemia, and thrombosis, which can be combined with beta The combination of salicylic acid is used to treat excessive platelet aggregation, ischemia or thrombosis, prevent drug-induced stains and / or improve male sexual function, in which the active ingredient is a combination of advanced aliphatic primary enzymes containing Bu 24 Alkane fermentation 0.5-1.0%, octacosanol 5.5-8.5%, octacosanol 2.0-3.5%, octacosanol 60.0-70.0%, octacosanol 0.5-1.2% ”Bu thirty thirty enzyme 10.0-15.0%, 1-tridodecyl alcohol 4.0-6.0% and Bu tridecane yeast 0.4-2. 0%, the ratio of this pharmaceutical composition to acetosalicylic acid is 20: 1 to 1: 20. 2. The metabolites composition as claimed in item 1 of the patent application, in which the combination of higher aliphatic primary alcohols contains 1-tetracosyl alcohol 0.8 ± 0.1%, 1-hexacosane yeast 6.7 persons 0.3%, Bu 20 Heptane fermentation 3.0 soil 0.3%, octacosane fermentation 65.6 soil 3.4%, 1-29-alkanol 0.7 ± 0.1%, triacontanol 12.5 soil 0.6%, tridodecane fermentation 5.0 soil 0.4 % And 1-tridecane yeast 0.8 ± 0.1%. 3. A method for preparing the active ingredient in the pharmaceutical composition as claimed in item 1 or 2 of the patent application, characterized in that the sugar cane is melted at a temperature of 9Q to 150 D, and the time range is from 3 Q minutes to 15 hours Internal use of alkali metal or alkaline earth hydroxide solution of samarium, saponification in a homogeneous phase with a hydroxide concentration ranging from 5 to 30%, using an organic solvent in the solid-liquid extraction system, in the range of 1 hour to 20 hours High-grade aliphatic primary leaven is extracted in the garden, and this organically soluble paper is used in the country's national rubbing standard (CNS) A4 regulation "grid (210X297mm) -------- ij installed ---- --Order ------ {ball (please read the notes on the back before filling in this page) A8 B8 C8 D8 printed by the Consumer Labor Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs 6. The range of patent application agents is from 6 to Hydrocarbons of 9 carbon atoms, tinctures of 3 to 8 carbon atoms, yeasts of 1 to 5 carbon atoms, halogenated or aromatic compounds and / or mixtures thereof, and optionally The product is recrystallized in the above organic solvent and / or mixtures thereof. 4 ♦ The method as claimed in item 3 of the patent application, in which sodium hydroxide, calcium and / or potassium are used as hydroxide dissolution. 5 * The method as claimed in item 3 of the patent application, in which pentane, hexane, heptane and / or octane are used as hydrocarbons in the extraction step. 6. A method as claimed in item 3 of the patent application, wherein acetone, amyl ketone, methyl ethyl ketone, methyl butyl ketone and / or 3-heptanone are used as ketones in the extraction step. 7 · The method as claimed in item 3 of the patent application, in which formazan, ethylenzyme, n-propanase, 2-propanol, n-butanol, 2-butanol, n-alcohol and / or tert-butanol are used in the extraction step Of yeast. 8. The method as claimed in item 3 of the patent scope, in which dichloromethane, 1,2-dichloroethane, chloroform, trichloroethane, 1,2-dichloropropane and / or 1, 2,3-tris Chloropropane is used as the haloform in the extraction step. 9. The method as claimed in item 3 of the patent application, wherein benzene, toluene, ethylbenzene, phenol and / or p-methyltoluene is used as the aromatic solvent in the extraction step. 10. It is used for the treatment of hyperlipidemia, as an antiplatelet agent, antithrombotic agent, anti-ischemic agent, as a protective and / or therapeutic agent against gastric ulcer, and it is used together with M Composition of animal sexual function-2-The standard of this paper is the Chinese National Standard (CNS) Α4 present format (210 X 297 mm) -------- η. 装 ------ 定- ----- ^ into (please read the precautions on the back before filling in this page) A8 B8 C8 D8 6. The scope of patent application, which can be tablets, capsules or granules, the special emblem is that it contains Q. 5-15.0% by weight of the active ingredients of the patent application range 1 or 2 and as pharmaceutical excipients 50.0-65.0% by weight of lactose, 10.0-20.0% by weight of corn starch, 3.0-6.0% by weight of sucrose, 6.0 -10.0% by weight microcrystalline cellulose, 1.5-4.0% by weight gelatin, 3.0-7.0% by weight croscarmellose sodium, 1.0-3.0% by weight talcum powder and 0.5-2.5% by weight hard Magnesium fatty acid, and optionally other pharmaceutical excipients. 1 1 • The pharmaceutical composition as claimed in item 1 of the patent application, wherein the ratio of the pharmaceutical composition to acetylsalicylic acid is from 10: 1 to 1:10. t Binding (please read the precautions on the back before filling in this page) Printed by the Consumer Labor Cooperative of the Central Bureau of Prototyping of the Ministry of Economic Affairs. The paper size applies to the Chinese National Standard (CNS) A4 (210X297mm)