TW229205B - - Google Patents
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- Publication number
- TW229205B TW229205B TW081108135A TW81108135A TW229205B TW 229205 B TW229205 B TW 229205B TW 081108135 A TW081108135 A TW 081108135A TW 81108135 A TW81108135 A TW 81108135A TW 229205 B TW229205 B TW 229205B
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Child & Adolescent Psychology (AREA)
- Anesthesiology (AREA)
- Addiction (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
PCT No. PCT/US92/08306 Sec. 371 Date May 20, 1994 Sec. 102(e) Date May 20, 1994 PCT Filed Oct. 6, 1992 PCT Pub. No. WO93/11106 PCT Pub. Date Jun. 10, 1993Compounds of the formula <IMAGE> I wherein Z is <IMAGE> or <IMAGE> R1 is <IMAGE> re each independently C, N, O, or S; wherein the remaining variables are defined in the specification, and the pharmaceutically acceptable salts thereof. These compounds are useful psychotherapeutics and are potent serotonin (5-HT1) agonists and may be used in the treatment of depression, anxiety, eating disorders, obesity, drug abuse, cluster headache, migraine, pain, chronic paroxysmal hemicrania and headache associated with vascular disorders, and other disorders arising from deficient serotonergic neurotransmission. The compounds can also be used as centrally acting antihypertensives and vasodilators.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US79674491A | 1991-11-25 | 1991-11-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
TW229205B true TW229205B (en) | 1994-09-01 |
Family
ID=25168947
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW081108135A TW229205B (en) | 1991-11-25 | 1992-10-13 |
Country Status (30)
Country | Link |
---|---|
US (1) | US5639752A (en) |
EP (1) | EP0619805B1 (en) |
JP (2) | JP2840448B2 (en) |
KR (1) | KR0184911B1 (en) |
CN (1) | CN1045294C (en) |
AT (1) | ATE190608T1 (en) |
AU (1) | AU671959B2 (en) |
BR (1) | BR9206810A (en) |
CA (1) | CA2124206C (en) |
CZ (1) | CZ281874B6 (en) |
DE (1) | DE69230803T2 (en) |
DK (1) | DK0619805T3 (en) |
EG (1) | EG21209A (en) |
ES (1) | ES2143992T3 (en) |
FI (1) | FI942395A0 (en) |
GR (1) | GR3033370T3 (en) |
HU (1) | HUT69705A (en) |
IL (1) | IL103798A (en) |
MX (1) | MX9206762A (en) |
MY (1) | MY109954A (en) |
NO (1) | NO301225B1 (en) |
NZ (2) | NZ245243A (en) |
PL (1) | PL173875B1 (en) |
PT (1) | PT101087B (en) |
RU (1) | RU2126399C1 (en) |
TW (1) | TW229205B (en) |
UA (1) | UA41297C2 (en) |
WO (1) | WO1993011106A1 (en) |
YU (1) | YU48456B (en) |
ZA (1) | ZA929082B (en) |
Families Citing this family (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5545644A (en) * | 1990-10-15 | 1996-08-13 | Pfizer Inc. | Indole derivatives |
US5578612A (en) * | 1990-10-15 | 1996-11-26 | Pfizer Inc. | Indole derivatives |
US5559246A (en) * | 1990-10-15 | 1996-09-24 | Pfizer Inc. | Indole derivatives |
US5607951A (en) * | 1990-10-15 | 1997-03-04 | Pfizer Inc | Indole derivatives |
US5559129A (en) * | 1990-10-15 | 1996-09-24 | Pfizer Inc | Indole derivatives |
DK0619805T3 (en) * | 1991-11-25 | 2000-06-05 | Pfizer | 5- (Hetero- or carbocyclylamino) -indole derivatives, their preparation and use as 5-HT1 agonists |
GB9207396D0 (en) * | 1992-04-03 | 1992-05-13 | Merck Sharp & Dohme | Therapeutic agents |
US6380233B1 (en) | 1992-04-07 | 2002-04-30 | Pfizer Inc | Indole derivatives as 5-HT1 agonists |
RU2101283C1 (en) | 1992-04-07 | 1998-01-10 | Пфайзер Инк. | Indole derivatives or their pharmaceutically acceptable salts |
ATE148465T1 (en) * | 1992-04-10 | 1997-02-15 | Pfizer | ACYLAMINOINDOL DERIVATIVES AS 5-HT1 AGONISTS |
WO1994002477A1 (en) * | 1992-07-24 | 1994-02-03 | Merck Sharp & Dohme Limited | Imidazole, triazole and tetrazole derivatives |
GB9226532D0 (en) * | 1992-12-21 | 1993-02-17 | Smithkline Beecham Plc | Compounds |
JP2860603B2 (en) * | 1993-08-31 | 1999-02-24 | ファイザー・インク. | 5-arylindole derivatives |
US5468768A (en) * | 1994-01-06 | 1995-11-21 | Bristol-Myers Squibb Company | Antimigraine derivatives of indolylcycloalkanylamines |
AU3162695A (en) * | 1994-08-03 | 1996-03-04 | Asta Medica Aktiengesellschaft | Indol, indazol, pyridopyrrol and pyridopyrazol derivatives with anti-asthmatic, anti-allergic, anti-inflammatory and immunomodulating effects |
GB9417310D0 (en) * | 1994-08-27 | 1994-10-19 | Pfizer Ltd | Therapeutic agents |
FR2724933A1 (en) * | 1994-09-22 | 1996-03-29 | Pf Medicament | NOVEL AROMATIC ETHERS DERIVED FROM INDOLES USEFUL AS MEDICAMENTS |
US5521196A (en) * | 1994-10-05 | 1996-05-28 | Eli Lilly And Company | 5-HT1F agonists for the treatment of migraine |
GB9420503D0 (en) * | 1994-10-11 | 1994-11-23 | Pfizer Ltd | Therapeutic agents |
GB9420529D0 (en) | 1994-10-12 | 1994-11-30 | Pfizer Ltd | Indoles |
US5521197A (en) * | 1994-12-01 | 1996-05-28 | Eli Lilly And Company | 3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists |
FR2731222A1 (en) * | 1995-03-02 | 1996-09-06 | Pf Medicament | NOVEL PIPERAZINE AMINOINDOLES CYCLIC DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS |
CZ288897A3 (en) * | 1995-03-20 | 1998-02-18 | Eli Lilly And Company | In position 5-substituted 3-(1,2,3,6-tetrahydropyridin-4-yl)indole and 3-(piperidin-4-yl)indole, as well as pharmaceutical composition containing thereof |
US5942536A (en) * | 1995-10-10 | 1999-08-24 | Eli Lilly And Company | N- 2-substituted-3-(2-aminoethyl)-1H-indol-5-YL!-Amides: new 5-HT1F agonists |
ES2159760T3 (en) * | 1995-11-14 | 2001-10-16 | Pharmacia & Upjohn Spa | DERIVATIVES OF ARIL PURINA AND PIRIDOPIRIMIDINA AND HETEROARIL PURINA AND PIRIDOPIRIMIDINA. |
AU712100B2 (en) * | 1996-02-23 | 1999-10-28 | Dow Chemical Company, The | Dispersions of delaminated particles in polymer foams |
US6107300A (en) * | 1996-03-27 | 2000-08-22 | Dupont Pharmaceuticals | Arylamino fused pyrimidines |
GB9609374D0 (en) * | 1996-05-03 | 1996-07-10 | Merck Sharp & Dohme | Therapeutic agents |
JP2001512727A (en) * | 1997-08-09 | 2001-08-28 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | Bicyclic compounds as ligands for the 5HT-1 receptor |
US6861448B2 (en) * | 1998-01-14 | 2005-03-01 | Virtual Drug Development, Inc. | NAD synthetase inhibitors and uses thereof |
US6673827B1 (en) | 1999-06-29 | 2004-01-06 | The Uab Research Foundation | Methods of treating fungal infections with inhibitors of NAD synthetase enzyme |
ATE271555T1 (en) | 1998-01-14 | 2004-08-15 | Uab Research Foundation | METHOD FOR PRODUCING AND SCREENING INHIBITORS OF THE BACTERIAL NAD SYNTHETASE ENZYME, COMPOUNDS THEREOF AND METHODS FOR TREATING BACTERIAL AND MICROBIAL INFECTIONS WITH THESE INHIBITORS |
US6204274B1 (en) | 1998-04-29 | 2001-03-20 | American Home Products Corporation | Indolyl derivatives as serotonergic agents |
US6310066B1 (en) | 1998-04-29 | 2001-10-30 | American Home Products Corp. | Antipsychotic indolyl derivatives |
US6066637A (en) * | 1998-06-19 | 2000-05-23 | American Home Products Corporation | Indolyl derivatives as serotonergic agents |
US5994352A (en) * | 1998-11-13 | 1999-11-30 | Pfizer Inc. | 5-arylindole derivatives |
SE9903997D0 (en) * | 1999-11-03 | 1999-11-03 | Astra Ab | New compounds |
SE9903998D0 (en) | 1999-11-03 | 1999-11-03 | Astra Ab | New compounds |
WO2001087845A2 (en) * | 2000-05-15 | 2001-11-22 | Fujisawa Pharmaceutical Co., Ltd. | N-containing heterocyclic compounds and their use as 5-ht antagonists |
FR2814166B1 (en) * | 2000-09-21 | 2005-07-01 | Innothera Lab Sa | 5-PHENOXYINDOLE DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS |
NZ526542A (en) | 2000-12-21 | 2005-01-28 | Glaxo Group Ltd | Pyrimidineamines as angiogenesis modulators |
WO2002060871A2 (en) * | 2001-01-30 | 2002-08-08 | Eli Lilly And Company | Benzenesulfonic acid indol-5-yl esters as antagonists of the 5-ht6 receptor |
DE10159922A1 (en) | 2001-12-06 | 2003-06-26 | Gruenenthal Gmbh | Substituted 2-pyrrolidin-2-yl-1H-indole derivatives |
DE10337184A1 (en) | 2003-08-13 | 2005-03-10 | Gruenenthal Gmbh | Substituted 3-pyrrolidine-indole derivatives |
PL1701940T3 (en) | 2003-12-23 | 2008-11-28 | H Lundbeck As | 2-(1h-indolylsulfanyl)-benzyl amine derivatives as ssri |
MXPA06012595A (en) * | 2004-04-29 | 2007-05-09 | Abbott Lab | Amino-tetrazoles analogues and methods of use. |
AR052308A1 (en) | 2004-07-16 | 2007-03-14 | Lundbeck & Co As H | DERIVATIVES OF 2- (1H-INDOLILSULFANIL) -ARILAMINE AND A PHARMACEUTICAL COMPOSITION CONTAINING THE COMPOUND |
SG158168A1 (en) * | 2004-12-23 | 2010-01-29 | Arena Pharm Inc | 5ht2c receptor modulator compositions and methods of use |
KR20130136010A (en) | 2005-04-13 | 2013-12-11 | 네우렉슨 인코포레이티드 | Substituted indole compounds having nos inhibitory activity |
US7629473B2 (en) | 2005-06-17 | 2009-12-08 | H. Lundbeck A/S | 2-(1H-indolylsulfanyl)-aryl amine derivatives |
AR054393A1 (en) | 2005-06-17 | 2007-06-20 | Lundbeck & Co As H | DERIVATIVES OF BENZO (B) FURANO AND BENZO (B) THIOPHEN, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE IN THE MANUFACTURE OF A MEDICINAL PRODUCT FOR THE TREATMENT OF DISEASES MEDIATED BY THE INHIBITION OF THE REINFORCEMENT OF AMINA BOSS NEUTRANTS. |
NZ566495A (en) * | 2005-08-12 | 2010-06-25 | Suven Life Sciences Ltd | Aminoaryl sulphonamide derivatives as functional 5-HT6 ligands |
WO2007035309A1 (en) * | 2005-09-15 | 2007-03-29 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
WO2007038669A2 (en) * | 2005-09-27 | 2007-04-05 | Irm Llc | Diarylamine-containing compounds and compositions, and their use as modulators of c-kit receptors |
EP1963275A2 (en) * | 2005-11-09 | 2008-09-03 | Abbott Laboratories | P2x7 receptor antagonists and uses thereof |
JP5350219B2 (en) | 2006-04-13 | 2013-11-27 | ニューラクソン,インコーポレーテッド | 1,5 and 3,6-substituted indole compounds having NOS inhibitory activity |
NZ586082A (en) | 2007-11-16 | 2013-03-28 | Neuraxon Inc | Indole compounds and methods for treating visceral pain |
EP2430019B1 (en) | 2009-05-14 | 2013-09-18 | Janssen Pharmaceutica, N.V. | Compounds with two fused bicyclic heteroaryl moieties as modulators of leukotriene a4 hydrolase |
KR101250606B1 (en) * | 2011-01-24 | 2013-04-03 | 이화여자대학교 산학협력단 | Benzothiazole and benzisothiazole derivatives as antagonist of 5-HT6 receptor, preparation thereof and pharmaceutical composition comprising the same |
CN102491935B (en) * | 2011-11-28 | 2013-10-16 | 山东大学 | Nitrobenzaldehyde indole schiff base, preparation method and application thereof |
CN102584671B (en) * | 2012-01-15 | 2013-08-07 | 山东轻工业学院 | Bis-Schiff bases synthesized by condensing indole-3-carboxaldehyde and benzidine and preparation method thereof |
CN102584670B (en) * | 2012-01-15 | 2014-04-02 | 齐鲁工业大学 | Indole-3-formaldehyde shrinkage phenylenediamine bis-schiff base and preparation method thereof |
US10154988B2 (en) | 2012-11-14 | 2018-12-18 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
KR102296703B1 (en) | 2017-03-20 | 2021-09-01 | 포르마 세라퓨틱스 인크. | Pyrrolopyrrole compositions as pyruvate kinase (pkr) activators |
US20230055923A1 (en) | 2018-09-19 | 2023-02-23 | Forma Therapeutics, Inc. | Activating pyruvate kinase r |
BR112021005188A2 (en) | 2018-09-19 | 2021-06-08 | Forma Therapeutics, Inc. | treating sickle cell anemia with a pyruvate kinase r activating compound |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA795239B (en) * | 1978-10-12 | 1980-11-26 | Glaxo Group Ltd | Heterocyclic compounds |
BE889931A (en) * | 1980-08-12 | 1982-02-11 | Glaxo Group Ltd | INDOLIC DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATIONS AS MEDICAMENTS |
US4833153A (en) * | 1985-11-08 | 1989-05-23 | Glaxo Group Limited | Indole derivatives |
GB8600397D0 (en) * | 1986-01-08 | 1986-02-12 | Glaxo Group Ltd | Chemical compounds |
GB8719167D0 (en) * | 1987-08-13 | 1987-09-23 | Glaxo Group Ltd | Chemical compounds |
GB8724912D0 (en) * | 1987-10-23 | 1987-11-25 | Wellcome Found | Indole derivatives |
GB8819024D0 (en) * | 1988-08-10 | 1988-09-14 | Glaxo Group Ltd | Chemical compounds |
US5245046A (en) * | 1988-11-14 | 1993-09-14 | The Upjohn Company | α-amino-indole-3-acetic acids useful as anti-diabetic, anti-obesity and anti-atherosclerotic agents |
US4983615A (en) * | 1989-06-28 | 1991-01-08 | Hoechst-Roussel Pharmaceuticals Inc. | Heteroarylamino- and heteroaryloxypyridinamine compounds which are useful in treating skin disorders |
IL96891A0 (en) * | 1990-01-17 | 1992-03-29 | Merck Sharp & Dohme | Indole-substituted five-membered heteroaromatic compounds,their preparation and pharmaceutical compositions containing them |
RU2160736C2 (en) * | 1990-06-07 | 2000-12-20 | Зенека Лимитед | Indole derivatives and physiologically acceptable salts and solvates thereof, methods of preparing thereof, drug for treatment or prophylaxes of clinical states for which administration of 5-ht1-like receptor agonist, and method of preparing thereof |
EP0592438B1 (en) * | 1990-10-15 | 1997-08-27 | Pfizer Inc. | Indole derivatives |
DE9112614U1 (en) * | 1991-10-10 | 1992-01-16 | Fleddermann, Jörg, 8000 München | Child seat for vehicles with airbag |
DK0619805T3 (en) * | 1991-11-25 | 2000-06-05 | Pfizer | 5- (Hetero- or carbocyclylamino) -indole derivatives, their preparation and use as 5-HT1 agonists |
US5409941A (en) * | 1992-02-03 | 1995-04-25 | Pfizer Inc. | 5-heteroyl indole derivatives |
FR2701026B1 (en) * | 1993-02-02 | 1995-03-31 | Adir | New derivatives of indole, indazole and benzisoxazole, process for their preparation and pharmaceutical compositions containing them. |
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1992
- 1992-10-06 DK DK92922831T patent/DK0619805T3/en active
- 1992-10-06 BR BR9206810A patent/BR9206810A/en not_active Application Discontinuation
- 1992-10-06 ES ES92922831T patent/ES2143992T3/en not_active Expired - Lifetime
- 1992-10-06 CZ CZ941280A patent/CZ281874B6/en not_active IP Right Cessation
- 1992-10-06 UA UA94005494A patent/UA41297C2/en unknown
- 1992-10-06 DE DE69230803T patent/DE69230803T2/en not_active Expired - Fee Related
- 1992-10-06 HU HU9401398A patent/HUT69705A/en unknown
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- 1992-10-06 CA CA002124206A patent/CA2124206C/en not_active Expired - Fee Related
- 1992-10-06 PL PL92303794A patent/PL173875B1/en unknown
- 1992-10-06 JP JP5510088A patent/JP2840448B2/en not_active Expired - Fee Related
- 1992-10-06 AU AU28961/92A patent/AU671959B2/en not_active Ceased
- 1992-10-06 AT AT92922831T patent/ATE190608T1/en not_active IP Right Cessation
- 1992-10-06 RU RU94028107/04A patent/RU2126399C1/en not_active IP Right Cessation
- 1992-10-06 WO PCT/US1992/008306 patent/WO1993011106A1/en active IP Right Grant
- 1992-10-06 KR KR1019940701744A patent/KR0184911B1/en not_active IP Right Cessation
- 1992-10-06 US US08/244,043 patent/US5639752A/en not_active Expired - Fee Related
- 1992-10-13 TW TW081108135A patent/TW229205B/zh active
- 1992-11-19 IL IL10379892A patent/IL103798A/en not_active IP Right Cessation
- 1992-11-23 PT PT101087A patent/PT101087B/en active IP Right Revival
- 1992-11-23 EG EG71892A patent/EG21209A/en active
- 1992-11-24 YU YU100892A patent/YU48456B/en unknown
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- 1992-11-24 ZA ZA929082A patent/ZA929082B/en unknown
- 1992-11-24 CN CN92113491A patent/CN1045294C/en not_active Expired - Fee Related
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- 1992-11-24 MY MYPI92002145A patent/MY109954A/en unknown
- 1992-11-24 NZ NZ272130A patent/NZ272130A/en unknown
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1994
- 1994-05-24 FI FI942395A patent/FI942395A0/en not_active Application Discontinuation
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1996
- 1996-02-26 JP JP8038320A patent/JPH08239363A/en active Pending
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2000
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