TW223634B - - Google Patents
Info
- Publication number
- TW223634B TW223634B TW080106545A TW80106545A TW223634B TW 223634 B TW223634 B TW 223634B TW 080106545 A TW080106545 A TW 080106545A TW 80106545 A TW80106545 A TW 80106545A TW 223634 B TW223634 B TW 223634B
- Authority
- TW
- Taiwan
- Prior art keywords
- taxol
- ring
- preferred
- derivative
- contracted
- Prior art date
Links
- 229930012538 Paclitaxel Natural products 0.000 abstract 4
- 229960001592 paclitaxel Drugs 0.000 abstract 4
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 abstract 4
- 238000003556 assay Methods 0.000 abstract 3
- 150000004579 taxol derivatives Chemical class 0.000 abstract 3
- 238000004113 cell culture Methods 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000001727 in vivo Methods 0.000 abstract 2
- 125000003566 oxetanyl group Chemical group 0.000 abstract 2
- 239000012359 Methanesulfonyl chloride Substances 0.000 abstract 1
- 102000004243 Tubulin Human genes 0.000 abstract 1
- 108090000704 Tubulin Proteins 0.000 abstract 1
- WETWJCDKMRHUPV-UHFFFAOYSA-N acetyl chloride Chemical compound CC(Cl)=O WETWJCDKMRHUPV-UHFFFAOYSA-N 0.000 abstract 1
- 239000012346 acetyl chloride Substances 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 230000003013 cytotoxicity Effects 0.000 abstract 1
- 231100000135 cytotoxicity Toxicity 0.000 abstract 1
- QARBMVPHQWIHKH-UHFFFAOYSA-N methanesulfonyl chloride Chemical compound CS(Cl)(=O)=O QARBMVPHQWIHKH-UHFFFAOYSA-N 0.000 abstract 1
- -1 triethyloxonium tetrafluoroborate Chemical compound 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/70—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with ring systems containing two or more relevant rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epoxy Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67043291A | 1991-03-18 | 1991-03-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW223634B true TW223634B (show.php) | 1994-05-11 |
Family
ID=24690379
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW080106545A TW223634B (show.php) | 1991-03-18 | 1991-08-16 |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0505047B1 (show.php) |
| JP (1) | JPH0684364B2 (show.php) |
| AT (1) | ATE137229T1 (show.php) |
| DE (1) | DE69210078D1 (show.php) |
| TW (1) | TW223634B (show.php) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994012198A1 (en) * | 1992-11-27 | 1994-06-09 | F.H. Faulding & Co. Limited | Injectable taxol composition |
| EP0835657B1 (en) * | 1992-11-27 | 2004-08-25 | Mayne Pharma (USA) Inc. | Stable injectable paclitaxel composition |
| US5973160A (en) | 1992-12-23 | 1999-10-26 | Poss; Michael A. | Methods for the preparation of novel sidechain-bearing taxanes |
| GB9705903D0 (en) | 1997-03-21 | 1997-05-07 | Elliott Gillian D | VP22 Proteins and uses thereof |
| PL366100A1 (en) | 2000-09-22 | 2005-01-24 | Bristol-Myers Squibb Company | Method for reducing toxicity of combined chemotherapies |
| AU2002239282A1 (en) | 2000-11-28 | 2002-06-11 | Transform Pharmaceuticals, Inc. | Pharmaceutical formulations comprising paclitaxel, derivatives, and pharmaceutically acceptable salts thereof |
| KR20230010817A (ko) | 2016-09-06 | 2023-01-19 | 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 | 파클리탁셀-알부민-결합제 조성물 및 그의 사용 및 제조 방법 |
-
1991
- 1991-08-16 TW TW080106545A patent/TW223634B/zh active
-
1992
- 1992-02-27 AT AT92301652T patent/ATE137229T1/de not_active IP Right Cessation
- 1992-02-27 EP EP92301652A patent/EP0505047B1/en not_active Expired - Lifetime
- 1992-02-27 DE DE69210078T patent/DE69210078D1/de not_active Expired - Lifetime
- 1992-03-13 JP JP4054677A patent/JPH0684364B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0505047A1 (en) | 1992-09-23 |
| DE69210078D1 (de) | 1996-05-30 |
| EP0505047B1 (en) | 1996-04-24 |
| JPH0684364B2 (ja) | 1994-10-26 |
| JPH0578342A (ja) | 1993-03-30 |
| ATE137229T1 (de) | 1996-05-15 |
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