TW214513B - - Google Patents

Description

A6 B6 214513 V. Description of the invention () (please read the phonetic notation on the back? Ning Xiang then write this page) The present invention is coveted by an eye for storing a liquid pharmaceutical substance and for administering the drug A device for potions, wherein the device includes a rigid cylindrical container for containing the medicinal substance, and a device, a dispenser on one end of the container, the dispenser is pseudo provided with a The mouth for application is provided with an orifice designed to form and place the eye drops on a patient's eye. Many devices that work in this way: all are devices designed to store and administer a medicinal substance to be placed on the patient's eyes in the form of drops of water are known. In most designs of these devices, the storage container pseudo-contains two walls made of elastic synthetic materials or appears in the form of a telescopic hose with folding walls, so as to make one use The pressure can be applied to the storage container to cause the liquid to be discharged in the form of water droplets. When the pressure is released, the elastically deformable container establishes a sucking force on the mouth of the application, and this sucking force will pseudo-form ^ —,. + The mouth Q, the end The last-drop of medicine is sucked back into the container. Printed by the Beigong Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs, because when the eye drops are applied, based on the proximity of the mouth and the eye, the eye hazard, or the eyelashes, the bacterial contamination of the mouth flap is Holding farewell cannot be avoided. The potion closest to the end of the mouth and mouth • Especially the most suitable eye water formed at the end of the mouth and mouth is the pollution that Texing easily loves the above situation. In addition, the humid environment is not conducive to the growth of bacteria, and the entry of the bacteria into the container cannot be avoided from this paper standard. This is called Zhongjiazhenbi (CNS) A 4 Han Chromium CMO X) 82.3. 40,000 21451 ^ A6 B6 Printed by the Beigong Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economy ¾ V. Invention Instructions () Exempt. When the last drop of eye drops is sucked back into the mouth, the entry speed of this bacterium is accelerated. In order to avoid all contamination of the pharmaceutical substance contained in the container, and in order to avoid the further development of the bacterial contamination, an appropriate preservative is added to this pharmaceutical tree. However, it should be noted here that the bactericidal effect of this preservative has its limited validity period. For this reason, the medical solution used as eye drops is only considered to have a sterile period of about 30 days after use from the first party. This restriction leads to financial loss and increases the risk of infection of the patient's eyes when the patient does not follow the instructions for use of the eye drops. This known system with flexible containers made of synthetic materials is not suitable for the sterilization of conventional high-pressure steam cookers * because the high temperature is unbearable for the conventional synthetic materials. This fact pretends to be the second reason for the use of bacterial preservatives. Unfortunately, the presence of preservatives at too high a concentration can actually cause considerable inconvenience because the preservatives cause certain important problems for the patient. They can cause deterioration of the cornea, irritation or allergies ... and so on. In order to eliminate the side effects caused by the preservative, the preservative must be eliminated from the eyedrop before the eyedrop is applied to the patient's eye. One known method is to place a film in the device, one (please read the note on the back of the merit first ¥ ^ and then write this page) 丨 Install. Order_. 泉.-? < · «. <:! ί tL «S'S ^: a · (CNS) ψ i JVij (2ι, ι X 297) 82. 3.  40. 000 21451 ^ a6 ____B6 V. Description of the invention () (Please read the precautions on the back before writing this page) A liner or a filter that specifically absorbs the preservative when the eye drops are applied. An example of such a method is shown in U.S. Patent No. 5,056,689 for being trapped. However, it is very difficult to design such an absorption method so as to act only on the preservative to be used to avoid the danger of acting on the medically active substance. The feasibility of the effective function of this absorption method is limited, and its research and development require a large amount of investment. The device of the previous US patent is equipped with a one-way valve body, so that the eye drops are prevented from being directly sucked back into the container through the mouth of the applicator, and another mouth is installed on the mouth The one-way valve body allows non-sterile air to be allowed into the container. The arrangement of the two one-way valve bodies cannot solve the pollution problem of the mouth and the solution. In addition to the cost of the absorbent material and the preservative itself, this design incurs additional costs. In practical application, the preservative is retained in the aqueous solution of eye drops, because it has been proved that the back suction of eye drops based on the elastic deformation of the container cannot be avoided, and in fact there is no method that can be designed to prevent The propagation of bacteria on the mouth and mouth applicator. Printed by the Beigong Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs-The same problem occurred in the device disclosed in the International Patent Application No. W Ο 91/16868. In addition, the device proposed by the patent application has a majority of disadvantages for a user. The scope of the disadvantages includes the inconvenience of simple use and danger to health. What is true here is that when the original paper Kf containing an elastically deformable container is suitable for China: ¾ 家 找 芈 (CNS) A 4 gauge Luo (210 X 297 M D 82. 3.  40,000 A6 21451 ^ _B6_ 5. Description of the invention () When the device is equipped with a filter for sterilization, the filter must be kept in a moist state to be able to effectively throw away, such a wet filter will cause an increasingly large Vacuum is established in the interior of the container, and the eye drops that are expelled by the pressure in the body of the container are partially sucked back to the killing filter after being applied , So prevent external air from penetrating into the container. After use, the strength of the flexible or collapsible walls on the container to form the eye drops drops becomes so great that it is inconvenient for a user to use this device. Furthermore, the phenomenon of the eye drops being sucked back cannot eliminate all possible dangers, because if the mouth is already contaminated by the eyes, such contamination will spread toward the inside of the device and come The filter for sterilization may be infected. Another problem that has not been solved by the known system is the regularity and accuracy of the formation of eye drops. What is known here is that a drop of eye drops must have a volume of less than 30 microliters (micro 1 iter s) to prevent the eyes from being "flooded" (" f 1 〇ded 〃). Further, the best force that has been applied by the messenger to enable him to produce an eyedrop from a dispensing device has been measured. This force is about 300 grams Power, and the power is constant during the entire period of use of the multiple distribution device. In addition, no matter how much power is applied to the device, there will not be a jet of water. Most of the conventional devices are unable to allow regular water droplets to be produced, as in 82. 3.  40. 000 ------------------------- installed ------, 玎 ------ " (please read the back first (Notes on this page will be written on this page) Employee Consumption Cooperation of the Central Bureau of Standards of the Ministry of Economic Affairs “A6 B6” V. Invention Description () It cannot be applied with a certain amount of power, so it is perverted to one of the eye drops. Losses and shortcomings in use. Some devices are intended to overcome these shortcomings by introducing a film, in which the film is used to absorb the preservative, but some are still found in the aqueous solution of eye drops. Preservative is the device that the device can not completely meet the required paint. The precise formation of a drop of eye drops that has not been sucked back, or the formation of a second drop of eye drops that is not required cannot be guaranteed by the solution provided above, regardless of the eye drops of the above solution Whether the aqueous solution contains a preservative. It has been noted here that in order to protect the health of the patient, all preservatives need to be removed from the aqueous solution of eye drops, and the method of absorbing preservatives to exclude preservatives cannot successfully overcome this The problem of partial contamination of the mouth of the device, or it is impossible to overcome the problem of distributing eye drops with a certain power and a certain accuracy, so the conventional device cannot be easily used by people. At the same time, the following facts must also be considered: because of the resorption effect, some aqueous eye drops are not maintained in a uniform state but form a foam state, the formation of this foam state when applying eye drops It is an unacceptable change. Printed by the Ministry of Economic Affairs, Central Standard Ju Rong Consumer Cooperative Society ^ (please read the notes on the back '; ·, Xiang Zaiyu writes a wooden page} Yi Ke Luan completely eliminates the preservatives in the eye drops aqueous solution and the eye drops The detailed specifications of the device (at the same time, the device is capable of ensuring the continuous sterilization of the aqueous ophthalmic solution contained in the container and held in the channel of the dispensing mechanism), which preferably has the following methods: ——Method It is possible to discharge the eye from a container with a certain force from the silver ruler Λ shift with the Chinese SS Home Retreat (CNS) Jia 4 Xianluo (21〇X 2S7 cm) S2. 3.  40. 000 214513 A6 B6 V. Description of the invention () Liquid-dissolved medicinal state Void 1 Stands up & E a The container should be avoided, but French water 1 may not be enough. i'-l 3's outflow water medicine eye is controlled but it is a column formed by the method. The bead is added after the water is removed from the water and the medicine is added to the eye. One pressure; the rest can be left in the mouth. The mouth of the square device should contain the I water in the eye shape of the medicine and the mouth and the tight package 1 and the pressure to increase the pressure. Make. , Misunderstanding and wrong, there is no way to be in the prescription liquid can be dissolved is the same as the prescription, the part of the eye with a dense part of the mouth will be empty and the bead turbulent water in the eye The mouth uniforms are evenly shaped and should be stopped here. * Can produce foam is a method of producing foam.  The device within 0 should be used for the prevention of the bacteria in the migration, but it is a French method (please read the note on the back first before writing this page).  Order.  In the Ministry of Propagation and Propagation □ The mouthparts should be distributed to prevent the bacteria, but the French Principality Li Yingzhuo showed the name in the European Union. Example 1 1 8 from 6 can be borrowed ο Yes 1 some ο 2 of the I method Α Party 1 Some Β This G was reported to the Ministry of Public Affairs and Economics Central Bureau of Standards Beigong Consumer Cooperative Printed-Technical knowledge and knowledge of the decision-making solution Note only the case 4 party 4 decision 5 solution 7 offer ο mention 2利利 专-二 Α 上-With P by E, the first to tell the eyes of the 'reagent for the prevention of this rot, need not need to be one of the highest degree of access to be received by the Ministry of gold law is not full and set It's difficult to show without disguise. The division of the distressed department is divided into two parts. The other family is struggling (cxs) A 4 (21fi χ 公 兮) S2. 3.  40. 〇〇〇 214513 Δβ Α6 __ Β6 Fifth, the invention description () Hydrocarbon Economy Ministry of Central Standards staff consumption cooperation to print the lack of a sum of things and the alpha device can not. There are also oral systems for medicines and medicines. Sex shots are the same as dangerous devices because of their mouths. They are filled with bacteria. There is no interlinkage of the system, the medicine injection device is the same as the measurable method, and the avoidance device should be controlled to the _ the part should be shot, and the count is no beads. In order to be used and use the connection between the connector and the bead injection system to make beads and use the water certificate, the use of a continuous-speed injection plug says that the separation can be used to control the water and ensure that the water is guaranteed to be waterless, and the passive injection is coming. The water and the water essence medicine were taken as medicine. It ’s easy to get the right place, the proper medicine, the current medicine, not the eye method, the eye type bacteria is used as a device, and the medium is dripping well, and the eye is out of the eye. The pollution reform should be appropriate, and the only thing used is that the anti-pillar is equipped with a mouthpiece. This piece of liquid is forbidden to be used for the whole set. When the mouth is connected, it is installed separately. The chopsticks-blood was re-installed and used as a drop-off. It is divided into the pilot test for the most eyebrow device. The device is indeed the same. The bead device is absolutely tested. Water kills it. . It is used as a match when there is a shortage. The water of the device is shot to prevent the drug form from being over the same. The same part is used to match the injection of the real water only. It is used by the eye and the false flow. The whole water method is used to divide the medicine into one. The implement must use the eye method which is changed to make medicine for this time. In the 〃, the water must be filled by the shape of the shape of the shape of the shape of the shape. , Use the borrowed shot to take the medicine, the filter shape is used to shoot back to the back of the device, and the alpha is to be used. The shot is applied to the eye, and the same injection 〃 the shot is the same as the decay of the water. A set of due to water bacteria bacteria method should have a glance. The anti-fouling and anti-counterfeit drugs are available in tubes and pressure killers. -装 ------ # ----- \ ^ · (Please read #Notes on the back of the first:) _ Item and then write this page) H rule Λιll 1 in 3: «孓 惜 准 （CN. S) A 4 gauge Luo (2! 〇 X 297 male wear 82. 3.  40. 000 214513 A6 B6_ V. Description of the invention () (please read the note on the back first and then write down this page). It is impossible to eliminate the risk of contamination and bacterial reproduction downstream of the filter between the second application. This S is also happening in all conventional devices, even those with a preservative mechanism that can be absorbed in medical substances in its interior, because the contamination of the mouth cannot be avoided and, in Bacterial contamination downstream of the preservative absorption mechanism cannot be avoided. Furthermore, once the uncontrollable residual pressure is removed, it will immediately cause the danger that the eye drops will not flow unnecessarily. Here, the undesirable flow is to be eliminated immediately. In order to accurately separate the eye drops. Such a flow elimination cannot be achieved by traditional pistons. The present invention is designed to overcome the shortcomings of conventional devices, and to provide a device that can meet the requirements stipulated in the above specifications and most recent requirements. At the same time, the present invention can simplify the manufacturing And convenient for patients. In order to achieve the above goals, the device according to the present invention has the following characteristics: the container is sealed on one of its consumer parts, which is on the end The distributor is equipped with a flow control device. The flow control device contains a di mL: the opening degree of the adjustment element is determined according to the initial force on the S-fluid substance. And the other end of the container is sealed by a sliding piston which is in line with the container, the sliding piston is arranged to generate the starting pressure, and the flow rate control device is connected to a corrosion resistant On the device of action, the anti-corrosion device for a set of medicinal substances located upstream of the orifice is a emblem activity 82. 3.  40,000 ρΛ 4513 Α6 Β6 Fifth, the description of the invention () (〇1 igodynamic) role. According to an implementation form of the present invention, the flow rate control device may include at least one thin film having modulated micropores thereon, and at least one modulated orifice or at least one elongated channel. Preferably, the container additionally contains an additional removable sealing method that is arranged to prevent contact between the medical substance and the flow rate control device during storage of the medical substance. This additional removable sealing method may be a removable sealed plunger, and the container may contain a bypass volume to at least partially receive the plunger when the medicinal substance is used. In a preferred embodiment of the present invention, the movable plunger includes at least one ring-shaped outer green to ensure the impermeability of the container during storage, and at least one lateral recess To ensure the flow of the medicinal substance during use of the device, the at least one transverse K-groove is arranged to communicate with at least one groove formed on the bottom of the container. According to the form of this embodiment, the height of the bypass chamber may be smaller or larger than the height of the movable sealing plunger. The Ministry of Economic Affairs, Central Bureau of Standards, 3 Industrial and Consumer Cooperation a-print (please read the note on the back before filling in this page) Preferably, the movable sealing plunger contains a central section with a smaller thickness, and the container It is the central section that has been provided with a stab needle that penetrates this plunger. Preferably, the stab needle is also movable and is placed on a movable lancet bearing support. -1 2- Sizhong (CNS> A 4 rules must (2l ·) X II, Shi) 82. 3.  40,000 Printed by the Staff Consumer Cooperative of the China Bureau of Standards, Ministry of Economic Affairs " 21451 ^ V. Description of the Invention () In another form of embodiment of the invention, the movable sealing plunger pseudo contains a single directional valve body. In order to reduce the remaining volume in the container to a minimum volume, the movable sealing plunger and the movable piston may respectively include at least a groove and a groove with a complementary shape and Protrusions of size. In all variant embodiments, the flow rate control device is arranged on the base of the dispenser, and preferably on the base of the applicator mouth of the dispenser. In a preferred form of embodiment of the invention, the device pseudo contains at least one port which is arranged on the end of the container and which leads into the interior of the bypass container In this way, the gas contained in the chamber can be discharged out of the chamber before using the device. The container may contain two compartments separated by a movable intermediate plunger, one of the two compartments contains a solution, and the other compartment contains a pseudo designed to dissolve in the solution Or mixed with the solution. In this form of embodiment, the container preferably pseudo-contains a central enlarged portion, the central enlarged portion is pseudo-arranged when the middle movable plunger is moved to the vicinity of the enlarged portion to act as The channel through which the liquid solution circulates. In an embodiment of the preferred form of the device of the present invention, a cover pseudo-limits the travel of the plunger to determine the mixing of the two components. In order to eliminate the discharge of the remaining part of the liquid after use, the -13- this, 燸 准 (CNS) A 4 (210 X 297) 82. 3.  40,000 --------------------------- installed ------. 玎 ----- # {a (read first? Attention to a good side ^ item and then write this page) A6 B6 214513 V. Description of invention () The piston can contain a rigid holding stopper and a A soft lining defining an internal cavity is defined, and this holding stopper pseudo includes a support short, and the height of the gold portion of the stopper and the support short is at least approximately the same as the height of the internal cavity. • In the preferred embodiment form of the device of the present invention, the piston pseudo contains a spring ring, which is arranged to exert an increasing thrust since it was arranged. Preferably, in all forms of spring embodiments, the container includes a round chrysanthemum-shaped envelope that pseudo-forms the inner wall of the container. In a particularly economical and efficient embodiment form, the cylindrical container of the figure is formed by a first tube and a second tube, wherein the second tube is sleeved on the first tube Inside, the first tubular body is sealed by a fixed seal and a movable piston, and the second tubular body contains a hollow rigid element, which is pseudo-mechanically connected to the movable piston and The sliding piston is connected, the fixed sealant contains a unidirectional valve body that allows the medical substance to flow toward the dispenser, and the bottom of the second tubular element is sealed. The cylindrical container is preferably sealed by a sliding piston, wherein the sliding piston is rigidly connected to a hollow rigid element mounted on the bottom of a casing, here the The cylindrical container is partially inserted in the interior of the shell, and the hollow element is in communication with the dispenser via a filter and / or the antiseptic sterilization device. In a preferred method according to an embodiment of the present invention, the flow rate control -14- 82. 3.  40,000 ---------------------------- installed ------ # ------ ^ (please read the back Matters needing attention and then fill out this page) Printed by the Workers ’Consumers Cooperative of the China Bureau of Loss of Standards, Ministry of Economic Affairs-214513 A6 B6 5. Description of the invention () The device contains a filter with a thickness. The filter with a thickness may include a sintered material, the sintered material may include at least one element, the element has a micro-activation effect of bacteria, wherein the element may be selected from heavy metals, these metals Compound. Or mixtures and mixtures of these compounds. The above-mentioned antiseptic and sterilizing device includes silver and / or silver oxide. According to a preferred method of an embodiment of the present invention, the device is so arranged that the predetermined volume is less than the volume of a drop of eye drops, and preferably, between the microliters (mi cor 1 eters) The ratio of the predetermined volume measured to the surface area of the antiseptic sterilization device measured in square millimeters is less than 1. In order to avoid the discharge of residual medical substances from the device, the piston is preferably provided with a flexible device to be arranged to absorb residual pressure. Printed by the Ministry of Economic Affairs, Central Bureau of Standards and Staff Consumer Cooperative κ (please read the note on the back ?; Xiang Zai writes this page> the above flexible device. It preferably includes a section with low resistance, the section with low resistance is installed on the side of the piston in contact with the medicinal substance, and the section with low resistance is arranged to change its shape When a thrust force is applied to the piston, and when the thrust force is over, the low-resistance section returns to its original state. The present invention will be better understood by referring to the disclosure of the embodiments and the accompanying description, where:-Figures 1A and 1 show the preferred implementation of the device according to the present invention-15- Big Middle 4 and a half (CNS) A 4 (: M0 X 297) 813.  40,000 214513 A6 B6_ V. Description of the invention () One of the forms of the embodiment is an axial cross-sectional view, and the 2 and 3 pseudo shows the other form of the preferred embodiment of the device according to the invention. A cross-sectional view, wherein, the two pictorial symbols respectively represent a storage position and a used position, and pictorial diagrams 4 and 5 pseudo represent a variant embodiment of the device according to the present invention, wherein the two pictorial diagrams Pseudo indicates a storage position and a used position, Figures 6 and 7 indicate detailed views of the device according to the invention, Figures 8 and 9 indicate another variation of the device according to the invention Embodiments, wherein the two pictorial pseudo | represents a storage position and a recruited position, respectively, and the circular representations 10 and 11 pseudo represent another variant embodiment of the device according to the present invention, wherein, The two pictograms respectively represent a storage position and a used position. Pictograms 12 to 20 pseudo-describe the various stages of preparation of the components used to obtain the device that can store the medicinal solution according to the present invention. The combination of these components, picture 2 1 It shows an embodiment of a special form of the device according to the present invention, in which the container pseudo contains two compartments, here, this device is shown in its storage position, 圔 示 22 pseudo indicates drawing 21 is the state of the device in an intermediate position, the figure 2 3 pseudo represents the state of the device according to the invention in the use position -1 5------------------- -------- Equipment ------ 1T ----- J ball (please read the note on the back and write the page first) " Clothing fm side with Zhonglianweijia (C'VS) Jia 4 Tuoluo (210 X 29m) S2. 3.  40. 000 A6 B6 214513 V. Description of the invention (), the figures 24 to 3 3 pseudo-describe these components and the combination of these components to obtain various procedures of a device according to the present invention. Here, the container of the device pseudo-contains As shown in the two parts shown in Figures 2 1 to 2 3, Ps 34 to 3 6 pseudo-illustrates a preferred form of implementation of the piston, wherein the pss pseudo respectively at rest and in use, P 3 Pseudo 3 to 3 8 are two views to illustrate the implementation of the device of the present invention, wherein the device of the present invention is in a stored state, Figure 39 is pseudo one of the device of the present invention is particularly advantageous One of the forms is a cross-sectional cross-sectional view of a circle, where the device is in a stored state, without drawing 4 0 and 4 1 pseudo-illustration of the embodiment of FIG. 3 9, which indicates that the device of this embodiment is in a Driving state and a distributing state, Figure 42 pseudo-represents a change of one of the embodiments shown by Figure 39, Figure 43 and 44 are a detailed view to illustrate the device according to Figure 42 The sliding piston, where the / piston is in a storage Status and a usage status 5 Refer to the indications 1 A and 1B, indicating that the device in the form of a preferred embodiment includes a cylindrical container 10, which is placed on one end of the container. One of the dispenser 11 and a sliding piston 12 is in misalignment with the container and is in a position opposite to the dispenser. A protective cover 13 is mounted on the dispenser 11. -1 7-(Please read the note on the back " item before writing this page)-° Ding, Ministry of Economic Affairs, Central Standards Bureau, 3 industrial and consumer cooperation, thorium printing-middle stubble, prince 4 wje (210 X 297嗲 A6 B6 214513 V. Description of the invention () (Please read the note on the back '-'> first and then write this page) This dispenser 1 1 pseudo consists of an applicator mouth 1 4, the applicator The mouth mouth has an orifice 15, which is designed to form the eye drops, where the eye drops are to be applied to the patient's eyes. This hole 15 is a The container chamber 16 formed on one end of the mouth of the applicator 14 communicates with the container chamber 16 through a side channel 17 and through a flow rate control device 19 to the interior of the container Connected, here the side channel 17 is formed between the inner wall of the applicator mouth and an insert 18, here, the flow rate control device 19 will be shown below. Here In one embodiment, the flow rate control device includes a thin film with modulated holes on it, which pseudo-seales the container 1 End, and the other end of the container 10 is sealed by the piston 12 2. The piston 12 is installed on the end of a piston cylinder 20, or is installed via a spring element 2 1 Set on the end of a plunger, the function of the spring element 21 will be described below. The Central Bureau of Economic Affairs of the Ministry of Economic Affairs R-Consumer Cooperative Printing-The piston 12 is actually composed of a sealing plug 22, of which The sealing plug 22 is a ring-shaped outer frame made of an elastomer material. The outer heald made of the elastomer material is fixed around a rigid stop 23 , And the stopper 23 is connected to the plunger 20 via the bullet element 21. In the above-mentioned Binsch form, the orifice 15 is formed by one end of an axial channel The portion is formed, the axial channel extends pseudo on the upper half of the mouth of the applicator. In the channel is preferably inserted into the 詖-silver tip 2 18- 82. 3.  40,000 copies of the country's idle work (CNS) Jiaruo Luo (210 X 297 y points) Ministry of Economic Affairs Central Standards Bureau employee consumption cooperation thorium seal ¾ V. Description of the invention () 4 'the silver sharp film 24 from its cation It is released and has a bacteriostatic gastric fruit ', and the silver pointed piece pseudo-maintains the orifice of the mouth of the applicator to be in the state of preventing stomach 2. In Fig. 1B, Wu stated more firmly that the silver tip 24 is maintained at a central position of 5 ± in an axial direction by a radial sheet 25 of at least two. Here, the silver tip 24 can be replaced by any material with equal effect, even the tip 24 is plated with the same properties by connecting the inner wall of the hole 15 part of the opening 15 in this channel The coating of the material replaces it. When the protective cover 13 is placed on the device, that is, when the cover is screwed on the mouth of the applicator (the mouth is provided with a male thread 26, and the inside of the cover is When placed on the opposite female thread 27), in fact it forms the end of the channel at the top of the mouth of the applicator, which defines a small chamber 2 8 immediately adjacent to the orifice 15 Therefore, after the device is used for the first time, the medical substance 29 contained in the chamber 10 can be contained in the tiny chamber 28. This trace amount of medical shuttle is sterilized and antiseptic by its instantaneous contact or continued contact with the silver tip. The flow rate control device 19 is composed of one or more thin films containing modulated holes on it, and the thin film can control the flow of the medicinal substance to the application through the side channel. The flow rate of the orifice 15 of the nozzle □. This device can make the pangolin substance have a loss of pressure load when the medicinal substance passes therethrough, wherein the loss is proportional to the pressure exerted on the medicinal substance solution by the chamber 12. On -19-! T: (CSS) ψ 4 «. «Δ- (210 X 29:) 82. 3.  40. 000 ---------------- (-------- install ------. ΤΓ ----- 二 f 锖 Read the notes on the back first :: · Item then domain · write this page) A6 B6 214513 V. Description of invention () (Please read the notes on the back before writing this page) This The cross-sectional area of the cylinder is a relatively large area, such as 25 0mm2, so in this pseudo need to apply a 2.  A thrust of 5 kg is used to achieve a pressure of 1 bar on the solution. However, in practice, a thrust of 1 kg is acceptable, because the thrust is high enough to be driven by Kaulu to drive the system, that is, the piston can be pushed with one index finger. The maximum pressure is about 〇.  The pressure of 4 bar, and experiments show that even a force equal to 2 kg is applied, it is not possible to produce a jet of water at the end of the mouth of the applicator, but will produce a Even water drops. Experiments can show that, as a result of the flow control device, drops of eye drops are formed outside the orifice 15 at a rate of one drop per second or every two seconds. These drops of eye drops have a volume between 20 and 40 microliters. The spring element 21, which cannot be taken by Kaulu as an indispensable element, makes the use of the device easier, and at the same time, it allows a user ’s thrust to be gradually applied to the piston or plunger . To explain in a colloquial way, the spring supplements the function of the flow rate control device to prevent an instantaneous excessive thrust force from being applied to the medical substance 29 contained in the container 10. Printed by the Ministry of Economic Affairs, Central Standard Resident Employee Consumer Cooperative-Figures 2 and 3 pseudo-describe a form of implementing the present invention, in which the container 10 is a long strip and it is sealed by a removable sealing plug 30 At one of its distal ends (that is, near the dispenser 11), when a user pushes the piston 12 by pressing the plunger 20, the sealing plug 30 is designed To be at least partly pushed to -2 0- Lai Yiwen of this grave violates the Zhongwei country 劓 犈 (CN-S) A 4 Yue Luo (2 〖0 X 29 了 H) 82. 3.  40,000 Printed by the Central Bureau of Standards of the Ministry of Economic Affairs 3 Industrial and Consumer Cooperatives κ 214513 A6 B6 V. Description of the invention () A bypass chamber 3 1 The bypass chamber 3 1 pseudo contains a side groove 32, the groove 32 is a fake The pharmaceutical substance contained in the container 10 can flow out of the container 10 through one or more axial channels 33, wherein the axial channel 33 is formed between the movable sealing plug 30 and the Between the inner side walls of the container 10, the channels 33 that communicate with the recess 32 are themselves connected to one or more radial pipes 34, and the radial pipes 34 are connected to one bit In the central section 3 5 upstream of the flow rate control device 19, the flow rate control device 19 is constructed by a membrane filter. Here, the spring embodiment of the present invention is used when the medicinal substance contained in the container cannot tolerate long-term (for example, three years) and the flow rate control device (that is, the membrane filter) Under the condition of contact, the contact is generally likely to last for a month. The movable sealing plug has a single task P: keep the medical substance 2 9 on a wall formed by the container 10, the ring-shaped outer green of the sealing plunger 2 2 and the movable sealing plug 3 0 One of the formed sealed spaces. Figures 4 and 5 show that the difference between this implementation form and the previous implementation form is that the container of this implementation form is lined, in other words, this container contains a circle made of glass material. Cylindrical liner 4 ◦Wrapped on the inner wall of the container. In this embodiment, the medical substance is enclosed in a space formed by the glass bush 40, the movable sealing plug 30, and the sealing plug 22 of the piston 12. 82. 3.  40,000 ------------------ ^ ------- installed ------, 玎 ----- τπ (please read the note on the back first τ :: Xiang Zaiyu wrote this page) A6 B6 214513 V. Description of the invention () In order to facilitate the installation of this independent container defined by the three-valued components located inside the body of the container 10, the walls of the container are relatively Preferably, there is a first interval 41 and a second interval 4 2, the inner surface of the first interval 41 has a diameter approximately the same as the outer diameter of the bushing 40, and the inner portion of the second interval 4 2 The diameter is larger than the outer diameter of the bush 40. The result of this design is that the bushing 40 can only be formed on the second section 42 by its friction against the inner wall of the section 41 and possibly by it. The centering tongue 43 is fixed at its position, so that the bush 40 can be easily positioned at its position in a shape that does not require excessive thrust. In this embodiment, it is possible to complete the automatic filling of the individual container. This automatic filling will be explained below with reference to the indications 12 to 17; here, the container is being filled Some medical substances were later introduced into the main body of the device, so that the device became stand-alone and could be used. Figures 6 and 7 are enlarged views, which illustrate in a more detailed manner the implementation form and method of operation of the movable sealing plug 30 of the device shown in Figures 4 and 5. The sealing plunger is actually in the form of an at least one ring green 44, when the sealing plug is in its storage position (that is, the sealing plug and the liner 40 phase of the container 10 (When it is closed), the ring-shaped bead 44 is partially flattened to form a channel for the circulation of the medical spot when using the device. Since the groove 3 2 is pseudo-same as the result of the groove defined with reference to the circle 2, once the bead green 4 4 position-22 ----------------- j ------- install ------. Order ------ j (please read the precautions on the back before writing this page) Printed by the Ministry of Economic Affairs, Central Standards Bureau, S Industry and Consumer Cooperative Society κ ** m and in use ^; 4 gauge Luo (210 X 297 Gong Shi) 82. 3.  40,000 A6 B6 314513 5. As a result of the description of the invention, the height of the bypass volume 31 is lower than the height of the movable sealing plug, so that the total height of the container 10 is relative to other embodiments It is possible to have a lower height, in which the bypass chamber of other embodiments must have a sufficient height to fully receive the movable seal plug. The design shown by the drawings 8 and 9 is the aforementioned different embodiment. Here, the design of the illustrations 8 and 9 replaces the movable sealing plug with a sealing plug 50. The sealing plug 50 is a design It's going to be pierced. For this purpose, the sealing plug includes a central section 51 with a thin thickness, and a needle 52 is mounted at the bottom of the container relative to the mouth of the crotch applicator. The annular outer crepe of the chamber has two protrusions 53, and the two protrusions 53 have a shape approximately complementary to the shape of the groove 5 4 of the movable sealing plug in the central section 51 of the thin thickness . During storage, the protective cover 15 is sealed as a lateral orifice of the vent 5. .  5. When the plug is moved and when the cap is unscrewed, the air initially contained inside the container and located downstream of the movable sealing plug 50 can be discharged. In fact, these openings 55 are sealed by one of the lower parts of the protective cover, this lower part falsely constitutes an unauthorized opening of the ring 56, which is attached to the On the cover part of the cover, when the user wants to use the device, the protection arm will be broken to open these openings. This design can also be changed here: the needle 5 2 is mounted on a movable lancet carrier support, where the carrier support is pushed into -2 3 _ (CNH) ψ 4 (210 X 25: ) (Please read the back note first. : V-item and then write this page) — Install · * π.  Yin You, Central Bureau of Standards, Ministry of Economic Affairs κχ 工 consumer cooperative S2. 3.  40. 000 214513 A6 B6 Printed by the Poverty Alleviation Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs-V. Description of the invention () Since entering the inside of the container, ensure that the sealing plug is penetrated. Figures 10 and 11 illustrate another form of implementation of the present invention. This form is derived from Figures 8 and 9, in which the central section of the movable sealing plug 5 7 is provided with a slit The one-way valve body 5 8 constructed by the hole, where no pressure is applied to the medicinal substance 29, the valve body 58 is closed, and when only the pressure is large enough to make this When the lip of a one-way valve plaque is partially opened, the valve 58 will be opened to allow the medical substance to pass through and flow to the flow rate control device 19. In the ring-shaped outer green of the piston in this embodiment, there is a protrusion 5 9 below, the shape of the protrusion is preferably complementary to the lip portion formed between the one-way valve body The shape of the groove, so that after the device is used, the protrusion will penetrate into the groove so that the final volume of the container or the remaining body is reduced to a minimum volume 〇In all the above embodiments, the flow control device appears in the form of a thin film containing a predetermined number of modulated micropores on it. here . It should be noted that this type of flow rate control device can be replaced by any other suitable mechanism, for example, a sufficiently small modulated orifice, a straight or spiral shaped elongated channel or other available Any suitable mechanism for modulating the flow rate, so that regardless of the amount of pressure applied to the piston of the device, the device can avoid the formation of a water column and enhance the formation of regular eye drops. The membrane filter is preferably a sterilization filter, the filter -24- (please read the Zhuyin on the back-> first. Xiang Zaicheng wrote this page) — Binding · Order-Chen · 82. 3.  40. 000 Α6 Β6 214513 V. Description of invention () (please first read the phonetic note on the back: ¥ item and then write this page) The hole can have a range between 〇. 1 and 〇. 4 5 chemi (micr 〇ns) The diameter, and preferably, the hole diameter is at 〇.  22 Chemi range, so as to prevent all sizes greater than 0.  22 micron solid particles, bacteria and other foreign matter. In all of the above-mentioned embodiments, at least one filter whose main function is to control the flow rate is installed, and at the same time, a anti-corrosion filter that prevents the particles from flowing through is used to absorb the antiseptic. The device may contain a second element, such as a membrane filter or a liner, to absorb the preservative. The use of the above design by the Staff Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs can directly obtain many advantages. Among these advantages, what is directly perceivable by the user is that the regularity of the accuracy of the drop of eye drops formed on the mouth of the applicator when the plunger is pushed is very regular. What is true here is that there is a predetermined volume of buns of eye drops that have a completely constant volume when used by this device. The @ 来 as a flow rate control filter that suppresses and prevents the medicinal substance from being discharged in the shape of a water column pseudo provides the regularity of the eye drops. This regularity is also obtained through a plunger with a spring, where the spring pseudo-forms a mechanism so that the stroke of the plunger moves slowly relative to the stroke of the piston. In practical applications, when the push is used to push the plunger, based on the result of the spring's elastic action, the user can compress the spring by a certain distance before causing the spring to move. The filter itself has a compression setpoint, when the applied force exceeds the compression setpoint, the medicinal substance will pass through the filter to form modulated water -25- 82. 3.  40,000 214513 A6 B6_ V. Invention description () beads. Furthermore, this filter also has a function of preventing the passage of particulate matter, wherein the particulate matter comes from a drug mixture that is a medicinal substance for the medical action, or from an element of the device. The particulate matter from the pharmaceutical substance itself may be the particulate matter that cannot be dissolved in the solvent during the product manufacturing process or the particulate matter that cannot be well mixed with the solvent, or the particulate matter may be Particulate matter due to polymerization during storage. Finally, some medical substances cannot withstand the sterilization effect of high temperature, so they are preserved unless it is acceptable to filter with a preservative sterilization effect, otherwise, it is necessary to add at least one antiseptic during the storage of these medical substances Agent. A filter designed to absorb the preservatives before using the medicinal substance, or a liner, can be inserted in the mouth of the applicator. It is a fact that these preservatives may increase the possibility of allergies and cause discomfort or side effects, so these preservatives must come to the medical substance before they are applied to the patient's eyes. Off. The filter placed on the end of the mouth of the applicator is to prevent contamination based on self-fine movement from the outside of the mouth and spreading inside the mouth of the applicator. Finally, the shield with a silver tip or any other suitable material on it ensures that the permanently active end of the distal end of the mouth of the applicator will not be infected. The advantages of the manufacturing of the device of the present invention are illustrated by the embodiments shown partially in Figures 4 to 7, in which the details of the container on the Figure 2-6 --------- -------- ^ -------- Install ------. 玎 ------- (Please read the notes on the back before filling this page)

Printed by the Staff Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs. Used as a standard π quasi (CN'-S) τ 4 «Luo (210 X 297 2’) 82.3. 40,000

A 2

ΛΛ 1 A

6 B Printed by the Beigong Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economy V. Description of the invention () The detailed status can be further understood from the illustrations 12 to 20. These pictures show the entire manufacturing process of the device, that is, the preparation and assembly of the different components. Figure 1 2 Pseudo-instructions include the steps of the following procedure: use an extractable nozzle tip to clean the cylindrical shell 4 0 and apply a layer of silicon on the Yi shell 4 Ο, the cylindrical shell The sleeve 40 is held in place by the operation of a clamp 61. The cylindrical sleeve 40 was previously cut from a glass tube by thermal shock and without a special shape. Then, as shown in Figure 13, this cylindrical shell is reheated and depyrogenated at a temperature of 30 Ot: in a furnace 62. Figure 14 illustrates the use of an axially movable plunger 63 to place the movable sealing plug 30. Drawing 15 shows the filling procedure of the container, or more precisely, the shell 4 is filled with the medicinal substance 29 by the filling of the extractable injector 6 4 under a pull. Fig. 16 shows the situation where the piston 12 is installed via an axially movable plunger 65. It is assumed here that the container has a completely cylindrical outer shape, and a large number of containers filled with medicinal substances can be placed in a container in a way to be connected to each other for subsequent use Use. In these subsequent procedures, the most useful one is the sterilization effect of the high-pressure steam cooker. This effect is provided under the condition that the medicinal substance 29 can withstand a relative increase in temperature. Explain the placement of the container in the device, of which -27- 82.3. 40,000 (please read the precautions on the back before writing this page) —install · .11. A6 B6 214513 V. Description of the invention () The device It was sterilized in an appropriate way beforehand. After this installation, the plunger 20 was brought to its position and connected to the piston as shown in Figure 19. Figure 20 shows one of the devices fully assembled and reversed. In this case, the device can also be stored in a container in a single or collective package. Figure 2 1 to 2 3 pseudo-symbolizes the storage and distribution device of the eyedrops, wherein the container 10 Z is divided into two compartments 10 za and 10'b respectively, the container 10 / The lower compartment 10'a may contain a hydrophilic salt 70 (as shown), or a powder, or a liquid, and the upper compartment 10 / b must contain a solution in a liquid state. As previously mentioned, the container 10 'is sealed on one of its threads by a movable sealing plug 30, and is sealed on one of its upper ends by a piston. An intermediate movable embolism 7 2 pseudo-separates the two compartments 1 ϋ z & 10 ′ b. In the form of this embodiment, the cylindrical casing 40 of the figure of the container 101 has a central enlarged portion 73, and the central enlarged portion includes a bypass channel when the entirety is used, and the following There is no further disclosure. Other components, such as the plunger 20 and the applicator mouth 14 have not changed in relation to those shown above. The drive of the device is shown in Figure 22. A first thrust force on the plunger 2 Q causes the movable intermediate plug 72 to move in the central section of the container, in which the swollen cylindrical shell pseudo contains the enlarged portion 73. The result of the movement of the intermediate plug 7 2 forged the flow of the solution -28-, -dh (C + VS) A4 (210 X 297 male * #) --------------- -一-installed ------, 1T ----- {% (please read the notes on the back before filling in this page) Printed by Beigong Consumer Cooperatives, Central Bureau of Standards, Ministry of Economic Affairs κ 82.3. 40,000 Central Ministry of Economic Affairs Printed by Beigong Consumer Cooperative of Standards Bureau. V. Description of the invention () Enter the compartment 10 za to dissolve the powder or the hydrophilic salt 70. By this method, the medical antimicrobial pseudomask is composed or reconstituted, and then the medical substance is used to form the eye drops to be applied to the patient's eye. The plunger 20 can be installed with a movable stopper in the form of a cover 74 to limit the travel required to mix the two components. The following steps, which are the steps used by this device, are described in Figure 23. At the end of the previous step (after all the solution has entered the compartment 10 / a), the piston 20 is pushed upward against the movable intermediate seal 7 2, at this time, the movable intermediate The seal 7 2 is pretended to form a single element that acts as the same piston. After pulling the movable stopper, the operation of the device in use is exactly the same as that of the device for a single component as previously described. A thrust P 2 on the piston initially discharges the gas contained in the bypass chamber, and before the movable sealing plug is completely moved into the bypass chamber, the thrust P 2 pushes the The movable sealing plug 30 enters the bypass volume 31, and then the previously formed medical substance can be circulated to form eye drops. Figures 2 4 to 3 3 pseudo-describe the steps of preparation and assembly of the components of the device previously described, where the container is in the form of a mixture of two components. The first step described by 圔 示 24, as described earlier, is to wash and apply a layer of silicone film to the shell 40 previously cut from a cylindrical glass tube. Among them, the central magnified part is faked by a -29- (CNS) r 4 (210 X 29:) 82.3. 40,000 ---------------- ^ ------- -Installation ------- 玎 ----- "Balls (please read the precautions on the back before filling in this page) A6 B6 5. Description of the invention () Regional heating steps are formed, here, this The heating step can be used to obtain the desired deformation. The next step is illustrated by the illustration 25, which is to make the shell 40 in a furnace 6 2 at a temperature of about 300. Perform reheating and defocusing (depyrogenat io η). The next step illustrated by circle 26 is pseudo-same as the one illustrated with reference to figure 14. Figure 27 pseudo-describes that a first component is filled in the device Components, here, the first component will be subjected to a hydrophilization treatment step in the future. This first component 70 ~ ~ after receiving the hydrophilization treatment step represented by 圔 示 28 It is possible to obtain the hydrophilic salt 70 contained in the compartment 10 < a. It should be noted here that during the implementation of the hydrophilization treatment step, the intermediate movable plug 72 and the cylinder Since the 40-phase casing is fully sealed, the round chrysanthemum-shaped casing 40 is fully sealed. During the operation step illustrated by the diagram 30, a plunger pseudo-pushes the middle movable seal 72 into it Central location, here (please read the precautions on the back and then write this page on the wall)-installed. Ordered. Economic Village Central Bureau of Standards, Beigong Consumer Cooperative Society, India and Han. After the quality of the ginseng} The thing and the thing will be the 2 seals of the tube medicine ο The same will be 7 密 明 圆 医 8 No 2 The thing is said to have the box type 7 Sealing and the preservation of the contents can be dense 2 OK «or Or seal the moving room 3 to be shown by the card in the case of moving the box secretly. The moving can be set in the picture, and the moving room can be set by the device and can be used in the state of the quilt .. ; Be planted in the {note on ο one can each piece of this piece is part of the other, the yuan is the bottom plug in the back of the room a 1 to live. Then in the coming 7 rooms the seal, in order to exist liquid It is stored in a dense mixture. The top shape of the fused side is set by the uppermost step 3, the step is the work after 3 installations. The instrument shows that the middle is set to operate 4 Rong Xiqi prisoner: ¾ ' (CNS) Y 4 ni Luo (2ic X 297 cm) 82.3. 40,000 214513 A6 B6 V. Description of the invention () Operation. It is clear here that in this case based on the presence of the hydrophilic salt in the container Sterilization is impossible because the hydrophilic salt cannot withstand such an operation. The installation of the container in the main body of the device, and the combination of the plug when the container is in its position so that the device can be stored and the steps are the same, which is the same as reference 18 to 20 The show is shown. As previously mentioned, the hydrophilic salt can be replaced by a powder or a liquid. Most of the operation steps designed to place the medical substance in the two compartments are the same as the operation steps shown in reference drawings 24 to 33. However, when one of the compartments contains a powder, it is necessary for Luan to place the dissolving limb in the upper compartment first, then to locate the middle movable seal, and finally to place Into the lower compartment. This is related to the reverse operation of placing the hydrophilic toilet and the solution as necessary to avoid contamination of the upper compartment with the powder. The steps of a non-contaminated operation of a container are further required to eliminate the particles of the powder, wherein the particles may be scattered outside the container. It should be noted in this Ben application that sterilization of one of the powders is usually impossible, because this powder cannot accept such an operation. On the other hand, when it is contained in the lower and upper compartments --------------------------------------------- ΤΓ ----- • Line 1 ^ (Read the precautions on the back and then write this page) The Central Standard of the Ministry of Hydrocarbon Economy is printed by the Consumer Welfare Cooperative Society. It is the real time or the quality is improved. The opening on the object is 0. To the room temperature, the medical solution is separated from the other side. The other should be dissolved-at this time, it is the liquid required: it can only be dissolved or, state, charge The fact that the filling of the outer nipple is true is that the substance is removed from the substance, the substance is α, the medicine is prescribed, and the medicine is prescribed to the doctor _ Fang the room 21, the other is the Fang Mingzhong base. 1 Yue Luo (21ΰ X 297 Gong Shi) 82.3. 40,000 214513 A6 B6_ V. Description of the invention () If there is any chemical transformation or decomposition, it is possible for one of the containers to be completely sterilized. The two embodiments are used in the same way as the previous embodiment, wherein one of the two compartments of the previous embodiment contains a hydrophilic salt. For all the above-mentioned embodiments, the following problems may arise from Ye. When the user pushes the piston, a small volume of air contained in the container is compressed, which may push a certain amount of liquid to flow out of the mouth of the applicator after the eye drops are applied This has big disadvantages. In order to avoid this shortcoming, a small sucking effect is established to suck back the uncontrolled eyedrop liquid since the end of the eyedrops. This effect is held by one of the pistons 12 The result of the design is obtained. As shown in FIG. 3 4, the piston 1 2 pseudo includes a rigid holding brake 1 2 a, the brake 1 2 a is connected with the piston rod to form the same element, and the piston 1 2 pseudo includes a surrounding one The green portion 1 2 b of the flexible ring side of the brake 1 2 a. A supporting short rod 1 2c is arranged at the bottom of the holding brake 1 2a, so that when the piston is at rest, the total height of the brake including the short rod 1 2 c is approximately the same as the annular side edge 1 The height of the internal cavity of 2 b is 12 d. When the piston is depressed, as shown in Fig. 35, the short rod 12c causes the annular side green to deform at one of the bottoms. After use, when the ring-shaped side green returns to its original shape, as shown in Figure 36, the shrinkage established in the container leads to a small suction effect -32- 82.3. 40,000- ----------------------- 装 ------. 玎 ------ ^ (Please read the note # on the back first, then 壜Write this page) Employee consumption cooperation of the Central Bureau of Standards of the Ministry of Economic Affairs Thorium seal 5th generation Employee consumption cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs-A6 B6 V. Description of invention (). In this way, the above-mentioned purpose is falsely achieved. Referring to Figure 3 7, the device contains a filter 90 which is mounted on the base of the mouth of the applicator. This filter has a considerable area. Inside the mouth of the applicator is camouflaged a sterilized silver sintered insert 91. In the embodiment indicated by the reference 38, the filter 92, which preferably has a bactericidal effect, has a small surface area. A silver insert 93 is preferably placed inside the mouth of the applicator. In the above two embodiments, the insert pseudo-defines an axial channel to allow the circulation of the medical substance. Figure 39 pseudo-illustrates another form of embodiment of the device of the present invention, which includes a first tubular element 100 which is pseudo-partially mounted on a second tubular element 1 having a sealed bottom 0 1 inside. The first tubular element is sealed by a fixed seal 102 and a movable piston 104, wherein the fixed seal 102 is arranged in one of the two ends close to the applicator mouth 1 of the device 0 3 on one end. The internal space formed by the fixed seal 10 2 and the movable chamber 104 in the first tubular element is to contain the medical substance. The second tubular element pseudo includes a sliding piston 105, which is mechanically connected to the movable piston 1 ◦ 4 by a hollow rigid element 106, wherein the hollow rigid element 106 is pseudo A channel is defined to read that the medical substance can flow out of the channel. The first tubular element 100 is inserted into a sleeve 1 0 7, -3 3-82.3. 40,000 ------------------ 一 ---- ------ Install ------. Order -------- (please read the precautions on the back before writing this page) 214513 V. Description of the invention () The envelope 1 07 itself One of the ends is an applicator mouth 103 covered by a removable protective cover 108. The second tubular element 101 appears to be covered by a cover 109, wherein the cover 109 generally has a sealed bottom placed inside the envelope 107. The cover 1 0 9 includes a cut groove 1 1 〇 or a surrounding channel, and the upper cover of the envelope 1 0 7 includes two or more elastic tongues mounted on a chute The object 1 1 1 acts in conjunction with the cut 1 10, so as to prevent the relative movement of the cover 10 9 from the envelope 107, while at the same time allowing its movement in the opposite direction. As shown in Figures 40 and 41, in order to use the device, it is necessary to move towards the first tubular element by pressing the bottom of the cover 109 sufficiently to push the second tubular element. This pseudo-generates the effect of moving the rigid element 106 forward, and then the tip 1 12 of the rigid element is pseudo-pierced in the central section of the movable piston 104 that has been penetrated beforehand After the movable piston, as a result of the movement of the sliding piston, the medicinal substance is pushed back into a chamber that is now free behind the third tubular element 105. As a result of this action, if all the night-state vertical medicine dragging properties were moved from the front of the device to the back of the device. The movable piston is injured. Move to the front and it is to block against the stamp printed by the Ministry of Economic Affairs Central Standards Bureau Tooling Consumer Cooperative * (please read the precautions on the back before writing this page). When the thrust is 1g When applied to the bottom of the device, it fakes a drop-by-drop flow of the medical substance. _Show 4 2 pseudo description of the device according to the present invention is not changed from 3 9 to 4 1 -34- 82.3. 40,000 814513 A6 B6 5 'Description of the invention (in the embodiment. 2 is by 2 is combined with the above figure Show (7. The sliding part is rigid and the central groove of the envelope 1 is fixed in this 2 7, the cycle S is formed in the slide 4 4 of the envelope, this state. Here will be 1 2 1 a is a solid element 1 2 opens the one-way. In this embodiment, a sliding piston 12 1 containing the medicine is sealed, the same in an envelope 122, the envelopes 12, 40 and 41) The device 1 is fixed by a picture 3 9 piston 1 2 element 1 2 3 and the envelope 1 2 2 machine mouth 2 2 pseudo-definition one and one application 5 and a silver cap-shaped one filter器 1 2. The container contains a week 1 2 7 series and one and the seal 1 2 8-to function, to

When the central groove surrounds the tongue-shaped inner part with a tongue-shaped inner D, the volume 2 is a large-sized envelope 1 mechanical phase 12 4 objects 1 2 surround the enlargement sleeve 1 2 to hold the container 1 container 1 0 to the same sleeve 1 0 2 2 bottom connection, connected 6 is part 1 2 is a container piston 1 2 1 The detailed shape of the container piston is shown in the picture 4 3 and the two pictures pseudo said that the device is in storage and in use It is noticed that the central part of the sliding piston 1 2 1 is a film. When the thrust force from the rigid 3 during use (shown in FIG. 4 4) deforms the shape of the film, there is a valve B 1 2 1 The effect of b comes to allow the flow of the medicinal substance ------------------------ installed ------ tr ----- 4: I--(Import the precautions on the back of Mit first, then fill out this page) Printed by the Ministry of Economic Affairs, Central Bureau of Standards, Employee Consumer Cooperatives, 3 clothes, a copy of the first permission is available. The examples in this book are the construction or the organic field, but these parts are all placed in it. It is a case of installing α. The fruit of the 〇 reveals; the effect of b and the fact that the 1 is the original position 2 the ribs are installed 1 The installed helper II shows justification The structure of the valve diagram is as follows: the list of the machine is up, and the indication is that it should be communicated to the pre-determination 82.3. 40,000 1 2 e /-

6 6 A B Printed by the Central Standards Bureau of the Ministry of Economic Affairs κκIndustry and Consumer Cooperatives-V. Description of the Invention () Xu Yanye drops are formed under a certain force. These mechanisms include a movable piston that has moved in one of the axial directions to establish a volume of eye drops in a container for storing medicinal substances, or includes a fixed piston and a slidable slide over the fixed piston Move the container, and ensure that the chamber is formed of a volume of water droplets containing one of the medicinal substances, wherein the medicinal substance is stored in this movable container. At the same time, there is also the possibility of preventing a vacuum from being established inside the container. These mechanisms include a movable piston and a rod rod, where the piston and the rod rod are not mechanically connected together, or S contains a movable piston and a unidirectional valve body, where the movable When the container is pulled, the one-way valve body is closed, or contains a fixed closure and a one-way valve body, or a movable covering the movable container without being connected to the movable container Plunger, the movable plunger prevents all possibilities of stretching the movable container by pulling the movable container, so that the container can only move in a single direction caused by thrust. At the same time, the organic ditch can be used to control the flow rate of the medicinal substance to produce regular and precise eye drops without the risk of forming a water column. These mechanisms include a flow rate controller, which is based on the pressure and viscosity of the eye_aqueous solution in proportion to the establishment of a load loss, '; ·' The flow rate controller is a pseudo-porous and It has the form of a filter with a thickness, which is obtained by compressing a powder or metal sphere with a Μ and then sintering to get 36- (please read the precautions on the back before filling out this page) 丨 installed. Order · line. In this: ¾¾ 'Home (CXS) Jiage (210 X 297) 82.3. 40,000 A6 B6 V. Description of the invention (, so in the via. The element of this organization is based on the movement of a large amount of water and sliding Here comes one of the most important things in the rate control, because the piston is against the millimeter beads. It is also not free here. The device should be flexible. This should be a drop of eye drops. This residual pressure and the borrow Caused by this. The invention is formed at the same time that the drop is formed. This device is considered to be leaning on this very unlikely to flow out without any avoidance. The equipment to be injected and the wall of the pressure device is accurate Power is the speed of flow It is indispensable to obtain the required precise water droplets by using a mechanism that is formed with a modulated hole or a narrow hole penetrating. It is impossible to accurately control the movement of the piston (friction force on the wall of the container, the piston The precise distance between them has produced a volume of 30 microliters. Because once the friction force is set by the flow rate controller, the piston causes the solution to come in the shape of a water column. It means that it is placed on the wall and also included after the application. The rate control mechanism is included in the mouth. There is a same mechanism in a living device that can be left in the plug against the device. The end part is an effect that has been widely used in this flow on a bullet device. Eliminating the residual pressure inside the container due to the movement of the piston, the load loss of the friction on the wall of the container and other factors are the first There is one of the second eye drops aqueous film on the form of eye drops. First read the precautions on the back and then fill out this page)

The Ministry of Economic Affairs, Central Bureau of Standards, 3 Industrial and Consumer Cooperatives printed K in the interval ^ janw sliding in the place is placed in the film in the middle of the area. The upper middle part ii can wear it in the mouth. Comes with a secret, but there is also a place to set the secret. The transparent and transparent hairdresser that encapsulates the secret may not have S2.3. 40.000% A6 B6. V. The description of the invention (), or will not produce too much Pressure, or will not drive the liquid water column in the mouth of the applicator back to the inside of the container. These mechanisms include a non-spiral cover. In the conventional system, the screw cap is usually provided with a sealing ring to seal the cap before the cap is fully tightened. The bottle is thus avoided to prevent the cap from being fully locked By the time of the bottle, a defective impermeability was established. This conventional design has the following disadvantages: it will generate excessive pressure and Dicheng eye drops to be awakened and flow back toward the inside of the container, which will cause bacterial contamination, or the air penetrates into the container As a result of the inside, foam is generated inside the container. At the same time, the device of the present invention also has additional mechanisms to eliminate turbulence in the mouth of the applicator. These mechanisms include a one-way valve body and a one-way moving piston, which is used to prevent liquid from being sucked back into the container. Finally, the device of the present invention has mechanisms to eliminate the propagation of bacteria, wherein the bacteria may move into the mouth of the applicator after a drop of eye drops is applied. These mechanisms are obtained by the emergence of materials that have a bactericidal effect or bactericidal automatic sterilization effect, in which the material is shaken or hydrolyzed by a full / if action. .long. These mechanisms include a component, a coating or an interposer, which can be porous or not made of heavy metals, such as silver, gold, platinum, tin, copper, for example. .Noble metals or semi-precious metals, etc., or a compound of the upper metal, especially oxides or mixtures of oxides, such as vaporized silver or Teflon (R) for example -38 «82.3. 40,000 ------------------------ installed ------ ΤΓ ----- ~ ^ f one (Qi Xian Read the precautions on the back and fill in this page) Central Bureau of Standards of the Ministry of Economic Affairs 0® Industrial and Consumer Cooperation Thorium Seal ¾ X) A6 B6 V. Description of the invention () Ceramics or any combination with similar non-crystalline hospitality and antiseptic sterilization effect Other substances, or ultimately, one of the above metals, compounds or substances are mixed or combined. One of the mouths of the applicator is also included in these mechanisms. This wait-and-see design allows the applicator to be formed and discharged after a drop of eye drops only retains an extremely small volume of residual eye drops. At this point, it should be noted here that the volume of the residual eye drops is ideally 10 to 20% of the volume of a drop of eye drops, so that the loss can be minimized, and the dose of the eye drops applied is It is large enough to compensate for the persistence of the anti-corrosion and sterilization effect of the above-mentioned residual volume of the active component on its part. The Ministry of Economic Affairs Central Bureau of Industry and Fisheries Consumer Cooperation Thorium issued a better solution of fennel. Pseudo-containment consists of inserting a porous rod inside the mouth of the applicator. It is obtained by conversion to alkane, thus providing a filter with a thickness. In fact, from the point of view of microbiology, it is necessary to obtain .. The form with the best effect is that the ratio of the surface area to the cross-sectional area is the largest possible ratio. The predetermined e product of the medicinal substance located in the dispenser close to the orifice of the applicator is preferably less than the volume of a drop of eye drops. The ratio between the predetermined b product measured in liters and the surface area of the anticorrosive device measured in square millimeters is in any case less than 1, and preferably less than 0.5. In summary, based on the overall design of the device of the present invention and the design of the individual components therebetween and the interaction between the individual components, the present invention provides a number of novel features for manufacturers and users. -3 9-82.3. 40,000 (Please read the notes on the back before writing this page) (CNS) ^ 4 ¢ 210 X 2S7 ^)

6 6 AB is the end of the knot is, even if the qi is the ground and the air is solid and solid, before using it, it should be used as a living quilt. It should be killed and only covered with α. Above is the actuator's pulling capacity-after that, the words can be absorbed by those who can be used without being installed, so they can be used only by the situation, but the situation is not jammed. Yes, it is possible to prevent the initial effect of the use of rot to prevent the initiation. In the case of a regular installation of non-ming 1, the cost of proof is to protect the device. The bacterium is killed. 〇Put the bacteria and kill the roots of the meridian in the medicine. The medicine should be used in the pseudo part of the mouth of the mouth. The special device is applied to the device. The acceptance of the description of the connection can not be used to ensure that the case is actually able to use the causal agent of the pseudo-hypocrite to prevent its rot, and the use of anti-bacteria makes it useless. 〇The package is contained in the bacterium-made untreated liquid to dissolve the geological foreign material. The medicine is 0.

The doctor of the osmotic bacteria fine medicine has the prognosis of the obstetric prevention institute to use this to make the first place the first pressure is still the residual cause. The clear liquid must be made in the first place. In order to move is a living example, one is one or one, and the one with gold is more or less the same. The one is not one, so its 0, the problem is solved by the stained and smeared artifacts and the penetrating people who are installed. Killing for decay is to prevent it, the fruit of the effect of the micro-killing of the effect of the active bacteria, the production of the effective oxygen of the ground, there is a gold to the gold, and the weight is 0. Attention ^ -item fill in this page) 丨 installed. Ordered. Λ ball. The Central Department of Economics and Trade Department of the Ministry of Economics and Consumer Affairs thorium printing ^ printed by the ^ every need to be in the, and for-is the good fruit grows bigger It is better to be a small product, and the surface is to be the surface quality of the contact body. The medicine and the doctor are treated by the silver accumulator body. It must be a bead of water accumulation. Every hole of the drop eye of the residual eye is due to. Xiaojia is close. It must be more close, it is after and in Accumulate, apply the medicine by the eyes of the body to set a medicine for this purpose. It is guaranteed to be 1 to protect 0 ~, people: Xie Youmao]] ^: ¾ home (C \ S) A.1 (21,) X 297 Second, points) 82.3. 40.000 A6

Fifth, the invention description () Ministry of Economic Affairs, Central Bureau of Standards, Employee and Consumer Cooperatives, the use of equipment to control the rate of use of c-type S-shaped actuator flow filter can be done thick and can also be used for external control All the oxygen-removing silver should be burned like this. And, set ----------------- (----------- install ------. 玎 ------- (please Read the precautions on the back first and then write this page) This is suitable for the mid-range: ¾ home m (CNS) A 4 regulations (a) i〇X 37) 8 ^ .3. 40,000

Claims (1)

Six, please invite patent Fanyuan A7 B7 C7 D7 The Ministry of Economic Affairs, Central Bureau of Standards, Employee Consumer Cooperative printed the dispenser of the medical substance and the application is formed and administered (10) The device is equipped with a pseudo containing the drug f and the other end of the container, And one of them is set up 2. The film of mass and application rate control hole 3. The device of mass and application rate control is a device for storing a liquid medicinal substance and applying a medicine containing this medical eye drops, which contains a The rigid cylindrical container contains a substance, and includes a container mounted on one end of the container, a dispenser mounted on the applicator, a mouthpiece, and the eye drops are used for dispensing The control device is on the top of the qualitative device. The flow anti-corrosion volume is as described in the application. It includes a flow end element of the device, and the initial sliding piston is the dynamic rate bacteria device. There is a micro patent. (19 beads at the rate control site, the control force is such that the moving piston is controlled so that it fits in the first branch of the positioning movement! Quality) contains the orifice, the eye-made device (flow The number of the rate element, and its (12) is arranged so that it is connected to the orifice. The item used for eye drops is at least the mouth of the device is the upper, which 19) controls the degree of opening , It should be sealed to produce an upstream connection □ (14) is designed to be used in, the container is sealed in place (1 9) is applied to the container is by the j in the container the initial pressure of corrosion Sterilized medicinal substance storage device for a liquid medicinal substance, in which the flow one has a modulated micropore as described in the scope of patent application _ Item .1 for storing a liquid medicinal substance V. Eye drops containing this medicinal substance The device, wherein the fluidization device (1 S) includes at least one modulated orifice. --------------- {-------- installed ------ ΤΓ ---- „-line (please read the notes on the back before filling in this Page) t (CNS> Ψ \ (· Μ〇X) Ministry of Economic Affairs Central Standards Bureau W Industrial and Consumer Cooperatives printed goods A7 B7 _. D7_ Six, apply for patent scope 4. If the application of patent scope item 1 is used to store a liquid Medicinal substance and device for applying eye drops containing this medicinal substance, wherein the flow rate control device (19) contains at least one narrow and long channel. 5. For storing a liquid medicament as in item 1 of the patent application Substance and device for applying eye drops containing this elixir, wherein the container (10) additionally contains an additional removable sealing method which is virtually arranged during storage of the medical substance The contact between the medical antifouling and the flow rate control device. 6. The device for storing a liquid pharmaceutical substance and applying eye drops containing the pharmaceutical substance as claimed in item 5 of the patent scope, wherein the additional sealing method Is a removable sealing plug (30, 50, 57). And among them, the container Contains a bypass volume chamber, the bypass volume chamber is arranged to receive at least a part of the embolism during the use of the medicinal substance 〇7. For the storage of a liquid medicinal substance and the application of the 6th A device for eye drops of medicinal substances, wherein the movable plug chamber (30) contains at least one ring-shaped enlarged portion (44) to ensure the impermeability of the container during storage, and contains At least one lateral groove (32) has ensured the flow of the medicinal substance during use. This groove is pseudo-arranged to communicate with at least one groove formed on the base of the container. 2. 1 '8. The device used for storing a liquid pannus medicament fa for administration of eye drops containing this medicinal substance as in item 7 of the scope of the patent application, in which the side ----------- ---- {-------- 装 ------ TΓ ---- One-line (please read the notes on the back before filling in this page) J- · / — ,, Ίi lV C The central rate of the Hyun Department is shouldered by X-Consumer A7 B7 C7 D7 6. The height injury of the patent application room is less than the mobile The height of the plug. 9. The device for storing a liquid pharmaceutical substance and applying eye drops containing the pharmaceutical substance as described in item 6 of the patent scope, wherein the height of the bypass volume is greater than the movable seal The height of the embolism. '10. The device for storing a liquid medicinal substance and administering eye drops containing this medicinal substance as described in item 5 of the patent scope, wherein the movable sealing embolism (50) contains a thin The central section of thickness (5 1), and wherein, the container is equipped with a puncture needle (5 2), which is arranged in the central section of the embolism to penetrate the embolism. 1 1. The device for storing a liquid medicinal substance and administering eye drops containing this vertical medicinal substance as in item 10 of the patent application scope, wherein the needle is fixed and is installed close to the flow rate Control device (1 9) 〇 / 1 2. The device for storing a liquid medical substance and administering eye drops containing this medical substance as described in item 10 of the patent application scope, wherein the lancet is movable and It is mounted on a movable spur carrier. 13. The device for storing a liquid medicinal substance and applying eye drops containing the medicinal substance as described in item 5 of the patent scope, wherein the movable sealing plug (57) pseudo contains a single directional valve (58 14 . The device for storing a liquid forbidden substance and applying eye drops containing this medicinal substance as claimed in item 6 or item of the patent scope, where, ---------------- f ------- 装 ------. 玎 -----!% (Please read the precautions on the back before writing this page) Zuoshe Yin ^^^^ ^ (cNs) m · * ^ X? 〇 *) Printed by the Employee Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs ^ A7 B7 C7 D7 VI. Scope of Patent Application The movable sealing plug (50, 57) and the movable piston (1,2) are respectively Contains at least one groove and at least one shape ^ size and protrusion complementary to the groove. 1 5 · The device for storing a liquid medicine and applying eye drops containing this medicine as described in item 1 of the scope of the patent application, wherein the flow rate control device (19) is arranged in the dispenser (11) on the base. 16. The device for storing a liquid pannus drug substance and administering eye drops containing this drug substance as in item 1 of the patent application scope, wherein the flow rate control device (19) is installed in the dispenser (1 1) 2 The mouth (14) of the applicator. 17. A device for storing a liquid pharmaceutical substance and administering eye drops containing the pangolin substance as claimed in item 6 of the patent scope, wherein the device includes at least one of which is arranged on the end of the container A vent hole (5 5), and the vent hole (55) is introduced into the bypass chamber to allow the gas contained in the bypass chamber to be exhausted to the bypass chamber before the device is used Outside. 18. If the device of the patent scope item 1 is required to store a liquid S drug substance and apply an eye drop containing the same drug substance, wherein the container (10 ') contains two health compartments (10 'a, 10'b), the two compartments (1 0' a, 丄 / b) are separated by a middle removable 1 'plug (7 2) 3 1 9. If the patent application is the first 8 weeks to store a liquid medical device --------- order -----? ·% (Please read the precautions on the back before writing this page) 'ΛΊ rh ^; · * >' f, (C \ ^) Π7 «η; {> f Μ | η V-• 'i' · &Quot; t) C7 D7 The Ministry of Economic Affairs, Central Standards Bureau, Employee Consumer Cooperative Printed 5th Generation VI. Patented scope of drug quality and device for applying eye drops containing this medicinal substance, of which, one of the compartments (10 ’ b) Pseudo-contains a solvent (71) and the other compartment pseudo-contains a substance (7 0), the substance comes to be dissolved in the solvent (7 1), in or comes from the solvent (7 1) phase mixing. '2 0. The device used to store a liquid pharmaceutical substance and 1 to apply eye drops containing this pharmaceutical substance as claimed in item 18 of the patent scope, wherein the container (1 0') contains a central enlarged part (7 3) \ The central enlarged portion (7 3) is a technical arrangement to form a passage through which the liquid solvent can flow when the / movable plug (72) approaches the enlarged portion (73). 2 1. A device for storing a liquid pharmaceutical substance and administering eye drops containing the pharmaceutical substance as described in item 18 of the patent scope, wherein the device pseudo includes a cover (7 4) to restrict the plunger (2 0) Mix the two components since the trip. 22. The device for storing a liquid medicinal substance and applying eye drops containing this medicinal compound as described in item 1 of the patent scope, wherein the piston (12) contains a rigid holding brake (12a ) And a flexible land envelope (1 2 b) defining an internal cavity (12 d), this holding brake (12a) includes a support short rod (12c), and wherein the brake and the support are short The total height of it at rest is approximately the same as the height of the internal cavity _ (/. 12d). 2 3. The device for storing a limb medical substance and administering eye drops containing this panacea drug substance as described in item 1 of the patent scope, of which (please read the precautions on the back before filling this page); ; I cons') τΏ \ ^ f > (° pv) 21451 ^ 6. Scope of patent application (please read the precautions on the back and then fill out this page) The piston (1 2) contains a pseudo is arranged to apply an increasing thrust The spiral spring (2 1). 2 4. As for the device for storing a liquid medicinal substance and administering eye drops containing the medicinal substance in item 1 of the patent scope, wherein the container (10) pseudo contains a cylindrical liner (40), the The round chrysanthemum liner (40) pseudo-forms the side wall of the container. 2 5. The device for storing a liquid / state medical spot and applying eye drops containing this pharmaceutical substance as described in item 1 of the scope of the patent application, wherein the round chrysanthemum-shaped container is made up of a first tubular element (100 ) And a second tubular element (101), the first and second tubular elements are pseudo-assembled with each other, the first tubular element is by a fixed seal (102) and by A movable piston (104) is sealed, and the second tubular element pseudo includes a hollow rigid element (106) mechanically and the movable piston (104) and the sliding piston (105) Connected together, the fixed seal (102) pseudo contains a single directional valve body, the single directional valve bun can make the medical substance flow to the dispenser, where the bottom of the second tubular element (101) is Be sealed. Printed by the Central Standards Bureau of the Ministry of Economic Affairs, 3 Industrial and Consumer Cooperatives 2 6. If the patent application item 1 is suspended from a device for storing a liquid medical substance and applying eye drops containing this medical substance, in which the cylindrical container ( 120) is sealed by a sliding piston (121) and a hollow rigid element (123). Here, the hollow rigid element is installed on the bottom of a valley (122), The bottom of the enclosure (1 2 2) is partially inserted into the round chrysanthemum-shaped container, and among them, ΓΓΝ'Ο Α7 Β7 C7 D7. 6. Applying for a patent fan garden, the hollow element passes through a passerby ( 125) and / or the antiseptic sterilization device communicates with the distributor. 27. The device for storage of a liquid medicine and the application of eye drops containing this medicinal substance, as described in item 1 of the patent application, where the flow rate control device pseudo includes a transitional device with a thickness. 28. A device for storing a liquid medicinal substance and applying eye drops containing this medicinal substance as claimed in item 27 of the scope of the patent application, wherein the over-mold device 5 with a thickness is made of a sintered material, the The sintered material contains at least one heavy metal with the effect of micro-activity system. The heavy metal is selected from heavy metals, compounds and mixtures of these metals and mixtures of these chemicals. f Please read the precautions on the back before filling in this page). Pack. Printed by the Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs " Medicine, medicine, s, medicine, medicine, medicine, state of mind measurement, state of silence. In the quantitative state, one is liquid, the other is liquid, one-store rice one, store. " Storage, storage, storage, storage, storage, storage. The product of two levels is the product of using water and oxygen to shake the hydroponic product, the product of the water tossing the barium, the medicinal eye or the medicinal eye or the eye of the eye! The eye of the eye 1 and the bead 3 The plastid The quality of the first quality water is set in the first quality enclosure, the gold enclosure, the water enclosure, the medicine pre-small, the enclosure, the medicine, the medicine, the medicine, the medicine, the medicine, the medicine, the medicine, the medicine, and the medicine. One drop for this amount, 11 for this package, please include this example, please include this application with a false application, which is included in the application package. It is less than the application package. Micro-room. Use 9 to apply bacteria ο to accumulate 1 and to accumulate 2 to apply 2 and kill 3 and buns 3 quality. The surface 3 and qualitative humic substance will be pre-medicated in the epidermal substance to prevent this substance. 丨 线 _ 1 ' V-', V > i ^ t A7 B7 9Λ45Θ _ "_ Sixth, the scope of patent application The piston is provided with an elastic device to be arranged to absorb the residual pressure. 3 3. The device for storing a liquid medical substance and applying eye drops containing this medical anti-foam as in item 1 of the scope of the patent application, wherein the elastic device includes a section with less resistance provided in the piston On the side of the bracelet that is in contact with the medicinal substance, and the interval is arranged to change the shape of the output thrust of this piston, and return to its original shape when the thrust ends. -------------- i -------- installed ------- 玎 ---- ί-line (please read the precautions on the back before writing This page) Printed by the Employees Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs? Generation • ί ^ · I ».-'T Γ? 7 I * > t · 5 1, ·) · · ·'