205002 Λ 6 __Η 6 _ 五、發明説明（） 本發明偽關於一配藥裝置，且更特殊地傜關於一適合 配與稀散流塍量之裝置。 本發明俗別闢於一種轡應病人吸入量以共與計*劑 量之配藥裝置。 計量劑量吸人器在治療或減輕呼趿疾病（例如哮喘病 )效應之減經的醫藥界極為著名。呼吸使動裝置補颶既知 ，且已成為許多專利申請之圭題。 經浒部十央梂準局只工消贽合作社印製 英國專利第1288971、英國專利第1297993、英國專利 第1335378、英國專利第1383761、英國專利第1392192、 英國專利第1413285、W085/01880、英國專利第2204799、 美國専利第4803978及歐洲專利第0186280A所述之吸入引 動配與装置係供與一加壓氣溶膠配與容器使用。該裝置包 括有一配與容器，而此容器則當操作閥之内部彈簧之壓缩 量夠多時能釋放一計量之氣溶膠内容物之閥。該配與裝置 常包括有一具有封口件、進氣口、供使配與容器内之閥發 生作用的引動裝置、一可放鬆地固定該計量閥於進料位置 用之鎖閂裝置、及一吸入逛應裝置，以供鬆開該鎖閂，以 便可將計量之氣溶膠化合物排放於封口件之區域内。整個 目的為使氣溶膠容器之藥劑排放量能與病人之吸入量一致 ，如此可使最大之藥物劑量能到逹肺之支氣管通道。 該鎖閂裝置偽常接至一閥，而此閥偽饗應吸入時所産 生之部份真空從鎖閂位置移至配與位置。 歐洲專利-A- 0 04 5 41 9號所述為一具有偏動裝置之吸入 裝置，此等偏動裝置單獨時所具之力不足以壓下該容器， 3 本紙張尺度遑用中a Η家樣準(CNS)T4規格(210x297公龙) 205002 Λ 6 Β6 經濟部中央榀準而员工消赀合作社印^ 五、發明説明（） 但所有傷動裝置一起則所具之力足以®下此容器。 歐洲專利-A-186280所述之裝置俱用磁鐵控制氣溶膠 容器之放洩。 美國専利第3605738號所述之各裝置中，氣溶謬容器 傣經由一計量室而與封口件相通。氣溶膠化合物之計量僳 排放於計量室，而此化合物$經由一吸入引動閥傳輸至封 口件。 i 英國專利第1269544所述之裝置中，其中氣溶膠容器 傜藉一槓桿及凸輪糸統移入一由鎖閂及一用以跳開鎖閂及 可將該容器之閥移至排放位置的壓力差動器所固定之進料 位置。 本發明之目的在提供一種計量劑量吸入器，其中藥劑 之釋放偽由病人之吸入予以引動。本發明之另一目的在提 供一種比先存技藝之配與器簡單及固结之吸入引動裝置。 依據本發明之一方面，己提供供與藥物輸送条統配合 使用之配藥裝置包括有一從該条统放洩藥劑計量劑量之裝 置，該放洩裝置包括有一供施加一能夠引動該条統内傳輸 裝置預負載用之裝置、一供加加一能防傳輸裝置引動之及 抗氣動力I均裝置.及一能釋放該反抗氣動力以允許預負 載 壓力或低於大氣壓的負壓力之空氣予以完成。該放洩裝置 會發生作用使壓力恢復至大氣壓力或回至先前之平衡狀態 ，如此，可使預負載之金力發生作用。 引動傳％^置及配與藥劑之置。 該氣動反抗裝置之提供可在放洩前籍保持於大於205002 Λ 6 __Η 6 _ V. Description of the invention () The present invention is about a dispensing device, and more specifically about a device suitable for dispensing a dilute flow rate. The invention is distinguished from a medicine dispensing device that responds to the patient's inhalation amount in total. The metered-dose suction device is very well-known in the medical field for treating or reducing the effects of menopausal diseases such as asthma. Breathing makes moving devices to compensate for hurricanes known, and has become the subject of many patent applications. Printed British Patent No. 1288971, British Patent No. 1279993, British Patent No. 1335378, British Patent No. 1383761, British Patent No. 1392192, British Patent No. 1413285, W085 / 01880, UK Patent No. 2204799, U.S. Patent No. 4803978 and European Patent No. 0186280A describe inhalation actuation devices and devices for use with a pressurized aerosol dispensing container. The device includes a matching container that can release a metered amount of aerosol contents when the internal valve of the operating valve is compressed enough. The dispensing device often includes a sealing device, an air inlet, an actuating device for the valve in the dispensing container, a latch device for loosely fixing the metering valve at the feeding position, and a suction Walk around the device to release the latch so that the metered aerosol compound can be discharged into the area of the closure. The whole purpose is to make the discharge volume of the aerosol container consistent with the patient's inhalation, so that the maximum dose of medicine can reach the bronchial passage of the lung. The latch device is normally connected to a valve, and part of the vacuum generated when the valve is to be sucked in moves from the latch position to the fitting position. European Patent-A- 0 04 5 41 No. 9 describes an inhalation device with a deflection device. The force of these deflection devices alone is not enough to press down the container. 3 This paper size is used in a Η Home sample standard (CNS) T4 specification (210x297 male dragon) 205002 Λ 6 Β6 Central Ministry of Economic Affairs and employee consumption cooperative printed ^ V. Description of invention () However, all the injured devices together have enough power container. The device described in European Patent-A-186280 uses a magnet to control the discharge of the aerosol container. In the devices described in U.S. Patent No. 3,605,738, the aerosol container Dai communicates with the sealing member through a metering chamber. The metering volume of the aerosol compound is discharged into the metering chamber, and this compound $ is transmitted to the sealing member through a suction pilot valve. i In the device described in British Patent No. 1269544, the aerosol container is moved by a lever and a cam system into a pressure differential which is a latch and a valve for tripping the latch and moving the container valve to the discharge position The feed position fixed by the device. The object of the present invention is to provide a metered-dose inhaler in which the release of the medicament is actually triggered by the patient's inhalation. Another object of the invention is to provide a suction actuation device that is simpler and more consolidated than prior art dispensers. According to one aspect of the present invention, a dispensing device provided for use with a drug delivery system includes a device for discharging a dose of medicament from the system. The discharge device includes a device for applying Device for preloading of the device, a device for adding and preventing a transmission device and anti-air power I. and a device that can release the anti-air power to allow pre-load pressure or negative pressure below atmospheric pressure to complete . The relief device will act to restore the pressure to atmospheric pressure or return to the previous equilibrium state, so that the preloaded gold force can act. Induced transmission and placement of medicines. The provision of the pneumatic resistance device can be kept at
(請先閲讀背而之注意亊項#项-^4頁) 裝- 線· 本紙張尺度逍用中曲《家«準(CNS)T4規格(210x297公址） 4 經濟部屮央標準灼A工消仰合作杜印製 ^05002__ΑΙ__ 五、發明説明（） 該裝置特別適合於具有關門當作傳输裝置之加壓吸入 氣溶膠一起使用。 本發明雖己ιί特別關於一種使用空氣之糸統加以説明 ，但理應了解，在一封閉条統中任何適合之氣體均可予使 用。 在一較佳裝置中，其中己提供一氣溶膠配與容器之收 容器。該收容器所包括之外室具有一封口件，以便病人使 用該裝置即可吸入。另外該收容器可包括一或更多痼進氣 口，以使空氣可通至該封口件。在外室中可包括有封閉氣 溶膠容器主賭之内袖套。該外室係在一端由一横構件界定 其範圔，此横構件可容纳氣溶膠之閥門並密封該室使不能 提供一氣溶膠出口。内袖套最好予以密封，以使其外室有 稻許氣密接觸，致使氣溶膠容器與内殼對橫構件可提供一 活塞效應，俾可以能防止引動氣溶膠閥門之高®容積之形 式，構成阻力負載。 在另一較佳裝置中，已提供有一供氣溶膠配與容器用 之收容器。該收容器可能包括有一具有一封口件以便病人 可使用該装置吸入之外室。該收容器可另外包含有一或更 多進氣口，以便空氣通至封口件。封閉氣溶膠容器主髏之 頂部份的内袖套可予包括在外室内。該内妯套最好予以裝 置，以便可構成空密活塞氣缸、風箱或膜Η,致使内袖套 之蓮動會導致活塞氣缸、風箱或膜Η内封閉容積之增加， 産生一真空或低壓容積，以構成能防止氣溶膠閥門引動之 反抗負載（力）。 本紙ft尺度边用中曲《家揉準(CNS)T4規格(210><297公；8：) - 5 - .(請先閲讀背而之注意亊項#艰"-M) 裝- 線- A 6 η 6 205002 五、發明説明（） ih 先 閲 讀 背 而 之 it 市 項 再 项. Η 在一實施例中，配與器之袖套，除代替提供一高»容 積外，並具有充作一滑動式氣密活塞之作用。離開主殼a 向下運動可産生一低壓容積。 在一較佳之裝置中，氣動阻力裝置之構成可藉内袖套 及外室中由一撓性風箱或藉袖套與至嵌體的筒形延伸部份 之間的滑動氣密封墊連结在一起之固定嵌體予以逹成。 在另一實施例中，該預負載為一對著氣溶膠閥門操作 之彈策。但此預負以由在外室中所設置之凹口中作樞軸旋 轉之槓桿予以供輸者較佳。該槓桿可採用一種抑制槓桿之 形式，以防加載彈簧在操作前對氣溶膠之發生作用。於操 作開始後，該槓桿係用以使彈簧再加負載。另外，該槓桿 可經由一插塞連接至一與内袖套接觸之彈簧，致使此槓捍 之運動可使該彈簧加載。 經濟部屮央標準局β工消仲合作杜印製 該放洩裝置為呼#引動式者較佳，以使藥劑之放洩能 與呼吸之攝入一致。該放洩裝置可在横構件中包括有一閥 口。該閥口通常偽由一可伸缩之閥轉板蓋住，而於引動時 才打開此轉板，使於氣動裝置中之壓力回至靜止狀態時， 該預負載可引動氣溶膠。在該實施例中，阻力為一空氣正 .壓力，閥口之打開可釋放積聚之壓力，而空氣可從封閉之 容積洩出，使預負載之全力可加諸在氣溶膠閥門上。在此 實施例中阻力為真空或接近真空，閥口之打開可讓空氣進 入該封閉之容積内，再讓預負載之全力作用於氣溶劑閥上 受人喜愛之呼吸引動式裝置包括有一可移動之葉片機 本紙尺度边用中8®家楳準（CNS)肀4規格（210x297公龙） _ 6 - 205002 經濟部屮央標準灼员工消费合作社印製 五、發明説明（） 構。此桀片機構視阻力元件之位置可予藏放該室之下或上 部。一閥之密封件以裝設於該葉片較佳，以致在吸入時， 該藥Η俗從其靜止位置移動至其引動位置，如此可將閥之 密封件移開而不與閥口接觸，而使閥打開。該葉Η機構以 可動力平衡者較佳，且例如可藉一彈簧而朝向其關閉位置 偏置。 該外室可包括有一可使空通至本裝置封口件之進氣口 。該等進氣口可採用槽或氣孔膜之形式。而後者特別適於 協助塵。 藥劑就其本身而論可為藥物或在任何形式之遞體，例 如包含一粉末或一氣髌遞醱。 本發明現將僅藉範例並參考諸附圖加以説明，在諸射 圖中： 第1圖為依據本發明之第一實施例在靜止位置時吸入 器的斷面圖； 第2圖為依據本發明之第一實施例在吸入引動時吸入 器的斷面圖； 第3圖為本發明之第二實施例的吸>0器之斷面圖； 第4圖所示為與第3圖所示實施例配合使用之膜片的 放大圖； 第5圖所示為在預引動及引動狀態時所在位置之該膜 片的一放大斷面圖。 如第1圖及第2圖所示吸入裝置通常偽由其搔斷面為 圓筒形之主體5組成。該主體所包含之實心橫構件10具有 (請先閲讀背而之注意市項#填·{)-頁) 本紙51尺度逍用中S S家楳準(CNS) Τ4規格(210X297公*) 205002 A 6 Π6 經濟部屮央櫺準工消费合作社印製 五、發明説明（） 一跨越主體5之一端的孔15。在主體5所含之袖套20具有 與主體5相似之横斷面。袖套20與主賭5二者之縱軸通常 為同軸。一^為圓筒形狀之既知型式的氣溶_配與容器25 傜容纳在袖套20内。袖套20所含之周邊封墊30俗與主體5 之内心35為滑動式氣密接觸。周邊封墊30可為一合成橡膠 或天然橡膠之封墊。該封墊可為一圍繞袖套20伸展之0型 環。另外，封¥ 3%為袖套20之口唇的必要部份。 氣溶膠配器25所具之莖40含有一氣溶膠配與閥 (在圖中未表示）。而孔15則可使其構成氣溶膠配與容器25 之莖40上的氣^^熟。肩部45可限制及定妥莖40之位置， 而莖4 0依序可膠配與容器在主體5中之位置。通道 50從孔15延伸，而且繼_從扃45伸展，以便與配與噴嘴55 互連。 如第1圖所示，具有樞軸60之主體5的末端備有一適 於接受一凸軸60上操作之凸輪槓桿70的凹入部份65。在靜 止位置，該樞軸可伸越凹入部份65,使凸輪槓桿70可繞箸 樞軸70旋轉。該凹入部份另外所含之一通常為囫筒形之通 道75可接受滑動插塞85與袖套20間之彈簧80。 如第2圖所示，凸輪槓桿延伸部份9 0於轉動9 0度後即 運動插塞85,使其滑動並壓縮彈簧80。 在主體5之對端為一封口件95,此封口件9 5傜由一横 構件10而與主體分開。封口件95包.括有一室1〇〇。配與噴 嘴55係伸入室100内。室1〇〇具有一値或更多個進氣口 1〇5 ，以致空氣可從此等進氣口 105通至封口件95内。葉片或 (請先閲讀背而之注意事項洱蜞 < ;頁)_ 裝- 訂- 線- 本紙張尺度遑用中BB家樣毕(CNS)TM規格(210父297公龙） 一 8 - 205002 Λ 6 Η 6 經濟部屮央梂準而Α工消赀合作社印製 五、發明説明（） 轉板110在其靜止位置在諸進氣口與封口件95 (請參見第 1圖）之間分開室100。葉片100可藉銷115装於樞軸上，以 致其可藉進氣口 1〇5(請參見第2圖）與封口件95之間的壓 降從其靜止位置向該封口件移動。 實心横構件10所含之小閥口 120俱由一可伸縮之閥轉 板125蓋住，及由其構造體偏置以靜止於封閉位置。轉板 125係藉樞軸而與横構件10連接，且在正常倩況下發生作 用以防止封閉空間130空氣之流出並有^^密封空間13 0。 閥莖135傜從閥口 120伸出且傜藉樞接至葉Η 110 。在藥移向引動位置時，莖135從閥口 120移出，使轉板 125打開。閥莖135與藥Η 110之植軸連接的定位，可使該 葉片大幅移動，而使閥莖135小幅移動，以增加閥轉板125 所施加之力。 在使用時，病人將氣溶膠配與容器裝入袖套20内。氣 溶膠容器可藉在主體5内提供一具粗螺紋之螺絲釘，使之 位於封墊30之上方，例如線條I-Ι之周圍而予加載。當 主髏5之部份已施出時，内袖套20於是能藉滑動而予移動 ，而氣溶膠乃可予嵌入。内袖套20及主體5乃能復位，而 該裝置己完成使用準備。 另外，該装置可予製成為一密封單位，於容器中之全 部劑量均已配用完畢時可予拋棄。 槓桿7 0偽在靜止位置（請參見第1圖），以致無負載經 由彈簧80施加至袖套20。空氣空間130為大氣壓。 槓桿70偽上升至加載位置（請參見第2圖）並使彈簧受 ·(請先W請背而之注意事項再项ί :、頁) 裝- 線· 本紙張尺度逍用中8困家楳毕（CNS)肀4規格(2]0χ297公釐） _ 9 - 205002 Λ 6 Η 6 經濟部屮央梂準局εχ工消份合作社印Μ 五、發明説明（) 插塞85之壓缩，而使袖套20及氣溶膠容器15進一步向下移 動。此一移動使封閉空間130内之空氣會受到壓縮。空氣 無法經由已被閥轉板125蓋住之閥口 120洩出。空間130内 所增之氣壓具有提供阻力負載之作用，以防止引動氣溶腰 閥。該項氣壓亦可增加閥口 120密封之效果。 袖套20及容器25繼缠向下移動直至壓縮彈簧80所施加 之力等於内彈策（其係引動配與容器之内閥）與由於封閉空 間130内壓力增加壓産生之力的合力為止。當各力平衡時 ，袖套20及容器25之位置偽由該封閉空間之尺寸大小與彈 簧80之彈性常數決定；而此等尺寸及彈性常數經予選定， 以致諸力之平衡剛好在氣溶膠容器25相對於其莖40已移動 足夠之量而導致劑量之放洩前達成。 某些標準氣溶膠容器在該容之莖40中含有一莖洞135 。在此情形下，當凸輪槓桿70上升至第2圖所示之加載位 置，封閉空間30中所陷存之空氣會經由莖孔140 ,經由通 路50及噴嘴55而洩出。當袖套20及容器25更向下移，壓縮 内閥彈簧時，莖洞135為閥橡膠所封閉，而封閉空間130中 之空氣乃予壓縮。 病人經由封口件95吸入時，即跨越葉Η 11〇産生一小 的壓力差動，而葉Μ110偽在一端裝設在樞軸上。壓力差 動可使葉Η 110從靜止位置移至引動位置。桀片110及下室 100之設計.使在引動位置時，空氣可自由地從各進氣口 105流至病人。 葉片110之向上移動使閥莖135上移而與閥轉板125接 (請先閲讀背而之注意事項#项i ,-τί) it 丁 % 本紙張尺度遑用中β β家楳準(CNS)甲4規格(210X297公釐) 205002 Λ (5 Π 6 經濟部屮央梂準局员工消货合作社印製 五、發明説明（） 觸並推開該轉板。閥轉板125之打開可放洩空間130中所壓 .縮之空氣。而使袖套20與容器25上之諸力發生不平衡。袖 套20及容器25藉彈簧80導因藥劑計量劑量之經由配與噴嘴 55之洩放及於病人吸入之同時之洩入封口件95而受迫下移 。如此病人乃可與藥劑之計量劑量而吸入空氣。 病人吸入該劑量後，凸輪槓桿70即回至其靜止位置。 此一情形可釋放彈簧80之負載，使袖套20及容器25在内部 閥彈簧影轡之下移回至其原來之位置。封閉空間130之容 積為之增加，空氣乃經由可伸縮之閥轉板125而流入空間 130至空間130内之氣壓回至大氣壓為止。 在如第3圖所示之可選装置中，吸入裝置傜由主體 4 00組成，此主體400之横斷面一般為圓筒形，且在一端具 有封口件段面40 5而在另一端則具裝有諸進氣口 420之端帽 4 07。一般為圓筒形之既知型式的氣溶膠配與容器25係装 設在該裝置之主髖内。該氣溶劑配與容器所具之莖40含有 一氣溶膠配與閥（未表示在圖中）。孔15之構形可使其在氣 溶膠配與容器25之莖40上構成一氣密式封墊。扃部50可限 制及定妥莖40之位置，而莖40依序可定妥氣溶膠配與容器 25在主體400中之位置。通路50從孔15伸出，.且繼續從肩 部45伸出而與配與噴嘴55互接。 配與容器之對端傣裝設在與主體400相似之楢斷面的 袖套4 20内。袖套420與主體4 00之縱軸通常為同軸。該袖 套係與主體之内壁為鬆滑動接觸，且可堃内包含有數個開 鑿之槽430 ,使在主體内有通過該袖套的空氣之自由通路 (請先閲讀背而之注意事項再^{十頁) ..裝< 訂- 線. 本紙5fc尺度逍用中曲B家樣率(CHS) T 4規格(210X297公*) 205002 Λ 6 Β6 經濟部中央榣準而β工消奸合作社印製 五、發明説明（） 。如現將加以説明，袖套420可藉保持與主體400之頂部連 接的膜Η 440之20相接，而固定在適當位置。如此，袖套 420可從主體之頂部有效地懸掛起來。 包括有一堅硬碟狀部份441、一具撓性而通常為圓筒 形之壁段445及一堅挺之接頭段447的塑造撓性膜片440 (如 第4圖所示的一端係藉快壓裝配法裝配在袖套中有意製造 之槽450的周圍。在膜片上另一模製之唇口 470可為壓缩彈 簧460之一端提供一建造良好之配合。該壓縮彈簧係如此 定位，且可袖套上自由發生作用。壓縮彈簧之另一端偽藉 環狀扃部481定妥位置在主體4 00之頂部份内所裝設之主要 為圓筒突緣之嵌件480中。此嵌件含有一槽490,而撓性膜 片440之碟形部份則撳壓裝配在此槽4 9 0内。 膜片接頭部份447與内袖套槽450間之連接經裝設為氣 密式者，而袖套42 2之頂表面的形狀則與膜Μ之内部一致 ，致在吸入器之靜止位置，兩表面極為近似，而二表面間 之封閉空間極小。 圓筒嵌件480係藉裝配於該裝置主賭内之端帽40 7固定 在適當位置。此一方法可在各進氣槽420與膜片之堅硬部 件441之間構成一室590。該室備一個或更多個之空氣通道 ,以致空氣可從進氣槽420通至封口件405。該膜片之堅硬 碟形部份441亦含有一小型閥門口 495,在正常情形下，此 小型閥門口 4 95偽由與嵌件480作樞軸連接之葉片55 0中所 装之閥封墊（轉板）所蓋住。 葉片55 0在其靜止位置可將室5 9 0在進氣口 4 2 0與連至 (請先間讀背而·y注意事項Λ-填(:-頁) 本紙張尺度遑用中曲《家楳準(CNS) Τ4規格(210X297公;¢) 12 205002 Λ 6 η 6 經濟部屮央榡準局A工消仲合作杜印製 五、發明説明（） 封口件的空氣通道580之間分開，以致該葉Η 550可藉進氣 口與封口件間之壓降從其靜位置移動。在窠片移至引動位 置時，閥封墊（轉板）540已充份移動，足可打開閥口 495。 (葉片$50可藉一軽彈簧之撓曲予以偏置而使其關閉，一配 重或磁鐵未表示在圖中。） 如第3圖所示，具有樞軸50 Q之主體末端擁有一適合 接受凸輪5 2 0之凹口部份，而與防塵帽蓋510結合為整體在 該樞軸上蓮動。該凹口部份另外含有一與主賭400内壁中 所模造之相似通道相通的通道。從内袖套420之下緣延伸 之凸輪從動件5 30對該凸輪發生作用，以致當防塵帽蓋在 其封閉位置時，該内袖套傜由該凸輪從動件驅使至其最上 位置。 當該防鷹帽蓋轉至其打開位置時，該凸輪C9T為如此， 以致該凸輪從動件可自由向下移動一充份之量，俥可引動 該裝置。 在其靜止位置時，防塵帽蓋510己關閉，凸輪從動件 5 30抑制内袖套4 2 0於其最上位置，致使膜片44 0與内袖套 頂表面422之間所佔的封閉空間最小，而彈簧4 6 Q予以壓缩 。閥口 495傜由閥封墊（轉板）關閉，而袖套420則自由離開 已如此卸載之氣溶膠罐25之頂部。 該防塵帽蓋打開後轉動整體凸輪520 ,使凸輪從動件 5 3 0下降量為ΑΑ。内袖套在彈簧4 6 0之作用下向下驅動。當 内袖套而下移動時，膜Η 44 0與内袖套間之封閉容積按線 性當量A z A '增加，當量A ' A /小於或等於ΑΑ。因閥口(Please read back to note #item # item- ^ 4 pages first) Install-Line · This paper scale is easy to use "Home" (CNS) T4 specification (210x297 public address) 4 Ministry of Economic Affairs Standard Standard A Manufactured by Gongxiaoyang Co., Ltd. Du Yin ^ 05002__ΑΙ__ V. Description of the invention () This device is especially suitable for use with pressurized inhalation aerosol with closed door as a transmission device. Although the present invention has specifically described a system using air, it should be understood that any suitable gas in a closed system can be used. In a preferred device, an aerosol dispensing container has been provided. The outer compartment included in the container has a mouthpiece so that the patient can inhale using the device. In addition, the container may include one or more air inlets to allow air to pass to the sealing member. In the outer chamber, an inner sleeve with a closed aerosol container can be included. The outer chamber is delimited at one end by a cross member which can accommodate the valve of the aerosol and seal the chamber so as not to provide an aerosol outlet. The inner sleeve is preferably sealed so that the outer chamber has airtight contact, so that the aerosol container and the inner shell can provide a piston effect on the cross member, which can prevent the high volume of the aerosol valve from being activated. Resistance load. In another preferred device, a container for aerosol dispensing containers has been provided. The container may include a mouthpiece so that the patient can use the device to inhale the outer chamber. The container may additionally include one or more air inlets to allow air to pass to the closure member. The inner sleeve covering the top of the main skeleton of the aerosol container can be included in the outside room. The inner sleeve is preferably equipped so as to form an airtight piston cylinder, bellows or membrane H, so that the movement of the inner sleeve will cause an increase in the enclosed volume in the piston cylinder, bellows or membrane H, creating a vacuum Low pressure volume to form a resisting load (force) that can prevent the aerosol valve from actuating. On the ft scale of this paper, use the Chinese song "Home Compression (CNS) T4 Specification (210 > < 297 g; 8 :)-5-. (Please read the back and pay attention to the item # 难 " -M) Line-A 6 η 6 205002 Fifth, the description of the invention () ih first read it and then the city item and then item. Η In one embodiment, the sleeve of the dispenser, in addition to providing a high »volume, and has It acts as a sliding airtight piston. A downward movement away from the main shell a produces a low-pressure volume. In a preferred device, the pneumatic resistance device can be connected by a flexible air box in the inner sleeve and the outer chamber or by a sliding air seal between the sleeve and the cylindrical extension to the inlay The fixed inlays together are formed. In another embodiment, the preload is a pair of strokes that operate against the aerosol valve. However, this preload is preferably provided by a lever pivoted in a recess provided in the outer chamber. The lever can be in the form of a restraining lever to prevent the loading spring from acting on the aerosol before operation. After the operation starts, the lever is used to reload the spring. In addition, the lever can be connected to a spring in contact with the inner sleeve via a plug, so that the movement of the bar can load the spring. Produced in cooperation with β Gongxiaozhong of the Central Standards Bureau of the Ministry of Economic Affairs. This venting device is preferred for those with a call-out type, so that the venting energy of the medicament is consistent with the breathing intake. The relief device may include a valve port in the cross member. The valve port is usually covered by a retractable valve rotary plate, and the rotary plate is opened only when activated, so that when the pressure in the pneumatic device returns to a stationary state, the preload can activate the aerosol. In this embodiment, the resistance is a positive air pressure. The opening of the valve port can release the accumulated pressure, and the air can escape from the closed volume, so that the full force of the preload can be applied to the aerosol valve. In this embodiment, the resistance is vacuum or near vacuum. The opening of the valve port allows air to enter the enclosed volume, and then allows the full load of the preload to act on the aerosol valve. The popular breathing device includes a movable The size of the blade machine's paper is used in the China 8® Homewood Standard (CNS) Sui 4 specification (210x297 male dragon) _ 6-205002 Printed by the Ministry of Economic Affairs Standards and Consumers Cooperatives of the Fifth, the invention description () structure. Depending on the position of the resistance element, the blade mechanism can be hidden under or above the chamber. The seal of a valve is preferably installed on the blade, so that when inhaled, the medicine moves from its rest position to its actuated position, so that the seal of the valve can be removed without contact with the valve port Open the valve. The leaf H mechanism is preferably dynamically balanced and can be biased towards its closed position, for example, by a spring. The outer chamber may include an air inlet that allows air to pass to the sealing member of the device. These air inlets can take the form of grooves or pore membranes. The latter is particularly suitable for assisting dust. The medicament can be a medicine or a delivery body in any form, for example, including a powder or a gas delivery system. The present invention will now be described by way of example only and with reference to the accompanying drawings. In the shots: Figure 1 is a cross-sectional view of the inhaler in a rest position according to the first embodiment of the present invention; Figure 2 is based on this The first embodiment of the invention is a cross-sectional view of an inhaler during inhalation induction; FIG. 3 is a cross-sectional view of an inhaler> 0 device of a second embodiment of the present invention; FIG. 4 is shown in FIG. 3 and FIG. An enlarged view of the diaphragm used in conjunction with the embodiment; FIG. 5 shows an enlarged cross-sectional view of the diaphragm in the pre-actuated and activated state. As shown in Figs. 1 and 2, the inhalation device usually consists of a main body 5 whose cylindrical cross section is cylindrical. The solid cross member 10 included in the main body has (please read the back-to-back attention item # fill · ()-page) this paper 51 scales for easy-to-use SS Jiayu standard (CNS) Τ4 specifications (210X297 public *) 205002 A 6 Π6 Printed by the Ministry of Economic Affairs, Gyeongbuk-Chung Junong Consumer Cooperative Co., Ltd. V. Description of Invention (1) A hole 15 that spans one end of the main body 5. The sleeve 20 included in the main body 5 has a cross section similar to that of the main body 5. The longitudinal axes of the sleeve 20 and the main bet 5 are usually coaxial. A known type of aerosol of cylindrical shape_matching container 25 is accommodated in sleeve 20. The peripheral seal 30 included in the sleeve 20 is in sliding airtight contact with the inner core 35 of the main body 5. The peripheral gasket 30 may be a synthetic rubber or natural rubber gasket. The gland may be an O-ring extending around the sleeve 20. In addition, the seal ¥ 3% is a necessary part of the lips of the sleeve 20. The stem 40 of the aerosol dispenser 25 contains an aerosol dispensing valve (not shown in the figure). The hole 15 can make the aerosol and the air on the stem 40 of the container 25 ripe. The shoulder 45 can limit and fix the position of the stem 40, and the stem 40 can be glued to the position of the container in the body 5 in sequence. The channel 50 extends from the hole 15 and then extends from the stern 45 to interconnect with the dispensing nozzle 55. As shown in FIG. 1, the end of the main body 5 having the pivot 60 is provided with a concave portion 65 suitable for receiving the cam lever 70 operated on a convex shaft 60. In the rest position, the pivot shaft can extend over the recessed portion 65, so that the cam lever 70 can rotate around the pivot shaft 70. One of the other portions of the recessed portion, which is generally a tube-shaped passage 75, can receive a spring 80 between the sliding plug 85 and the sleeve 20. As shown in Fig. 2, the cam lever extension 90 moves the plug 85 after rotating 90 degrees, causing it to slide and compress the spring 80. At the opposite end of the main body 5 is a sealing member 95, which is separated from the main body by a cross member 10. The sealing member 95 includes a chamber 100. The matching nozzle 55 extends into the chamber 100. The chamber 100 has one or more air inlets 105, so that air can pass from these air inlets 105 into the sealing member 95. Blade or (please read the notes beforehand Er Er <; page) _ Binding-Binding-Line-This paper size is not used in the BB home sample Bi (CNS) TM specifications (210 father 297 male dragon) One 8- 205002 Λ 6 Η 6 Printed by the Ministry of Economic Affairs and printed by A Cooperative Society V. Description of the invention () The rotary plate 110 is at its rest position between the air inlets and the sealing member 95 (see Figure 1) Separate the room 100. The blade 100 can be mounted on the pivot by means of a pin 115, so that it can move from its rest position to the sealing member by the pressure drop between the air inlet 105 (see FIG. 2) and the sealing member 95. The small valve port 120 included in the solid cross member 10 is covered by a retractable valve rotating plate 125, and is offset by its structure to rest in the closed position. The rotating plate 125 is connected to the cross member 10 by a pivot, and occurs under normal conditions to prevent the outflow of air in the enclosed space 130 and has a sealed space 130. The valve stem 135 extends from the valve port 120 and is pivotally connected to the leaf H110. When the medicine is moved to the actuated position, the stem 135 is moved out of the valve port 120, so that the rotary plate 125 is opened. The positioning of the stem of the valve stem 135 and the plant axis of the medicine H 110 allows the blade to move greatly, and the stem 135 to move slightly to increase the force exerted by the valve rotating plate 125. In use, the patient fits the aerosol container into the sleeve 20. The aerosol container can be loaded by providing a screw with a thick thread in the main body 5 so that it is located above the packing 30, for example, around the line I-1. When part of the main skeleton 5 has been dispensed, the inner sleeve 20 can then be moved by sliding, and the aerosol can be embedded. The inner sleeve 20 and the main body 5 can be reset, and the device is ready for use. In addition, the device can be made into a sealed unit and can be discarded when all the doses in the container have been dispensed. The lever 70 is in the rest position (see Fig. 1) so that no load is applied to the sleeve 20 via the spring 80. The air space 130 is atmospheric pressure. The lever 70 is pseudo-raised to the loading position (please refer to the second picture) and the spring is received. (Please pay attention to the matter first, then the item: page). Installation-Line · This paper size is used for 8 sleepy families. Bi (CNS) 4 specifications (2) 0 × 297 mm) _ 9-205002 Λ 6 Η 6 Printed by the Ministry of Economic Affairs, Central Bureau of Economics, εχ Gongxiao Cooperative Society V. Description of invention () The compression of plug 85 causes The sleeve 20 and the aerosol container 15 move further downward. This movement causes the air in the enclosed space 130 to be compressed. Air cannot escape through the valve port 120 that has been covered by the valve rotating plate 125. The increased air pressure in the space 130 has the function of providing a resistance load to prevent the aerosol waist valve from being activated. This air pressure can also increase the sealing effect of the valve port 120. The sleeve 20 and the container 25 continue to move downward until the force exerted by the compression spring 80 is equal to the combined force of the internal spring force (which is actuated by the inner valve of the container) and the force generated by the pressure increase in the enclosed space 130. When the forces are balanced, the positions of the sleeve 20 and the container 25 are determined by the size of the enclosed space and the elastic constant of the spring 80; and these sizes and elastic constants are selected so that the balance of the forces is just in the aerosol The container 25 has moved a sufficient amount relative to its stem 40 to cause the dose to be released before it is released. Some standard aerosol containers contain a stem 135 in the stem 40 of the container. In this case, when the cam lever 70 rises to the loading position shown in FIG. 2, the air trapped in the enclosed space 30 will escape through the stem hole 140, through the passage 50 and the nozzle 55. When the sleeve 20 and the container 25 move further downward and compress the inner valve spring, the stem hole 135 is closed by the valve rubber, and the air in the enclosed space 130 is compressed. When the patient inhales through the sealing member 95, a small pressure differential occurs across the leaf H110, and the leaf M110 is pseudo-mounted on one end at the pivot. The pressure differential causes the blade H 110 to move from the rest position to the actuation position. The design of the blade 110 and the lower chamber 100. In the actuated position, air can flow freely from each air inlet 105 to the patient. The upward movement of the blade 110 causes the valve stem 135 to move up to be connected to the valve rotary plate 125 (please read the back-end notes #item i, -τί) it Ding% This paper standard is used in the β β family tree standard (CNS ) A 4 specifications (210X297 mm) 205002 Λ (5 Π 6 printed by the Employee Consumers ’Cooperative of the Central Bureau of the Ministry of Economic Affairs V. Invention description () Touch and push open the rotary plate. The valve rotary plate 125 can be opened when opened The compressed air in the vent space 130 causes the forces on the sleeve 20 and the container 25 to be unbalanced. The sleeve 20 and the container 25 are guided by the spring 80 to discharge the metered dose of the drug through the dispensing nozzle 55 At the same time when the patient inhales, it is discharged into the sealing member 95 and forced to move downward. In this way, the patient can inhale air with the metered dose of the medicament. After the patient inhales the dose, the cam lever 70 returns to its rest position. The load of the spring 80 can be released, so that the sleeve 20 and the container 25 move back to their original positions under the influence of the internal valve spring. The volume of the enclosed space 130 is increased, and the air is transferred through the retractable valve rotating plate 125 The air pressure flowing into the space 130 to the space 130 returns to atmospheric pressure. As shown in Figure 3 In the optional device shown, the inhalation device consists of a main body 400, which is generally cylindrical in cross-section and has a sealing member section 405 at one end and air intakes at the other end The end cap 4 07 of the mouth 420. The generally known aerosol dispensing container 25 of cylindrical shape is installed in the main hip of the device. The stem 40 of the aerosol dispensing container contains an aerosol dispensing Valve (not shown in the figure). The configuration of the hole 15 allows it to form an airtight seal on the stem 40 of the aerosol dispensing container 25. The stern portion 50 can restrict and fix the position of the stem 40, and the stem 40 can sequentially determine the position of the aerosol dispensing container 25 in the main body 400. The passage 50 extends from the hole 15 and continues to extend from the shoulder 45 to interconnect with the dispensing nozzle 55. Pair with the container The end dais are installed in a sleeve 4 20 similar to the main body 400. The longitudinal axis of the sleeve 420 and the main body 400 are usually coaxial. The sleeve is in loose sliding contact with the inner wall of the main body and can be bent. There are several grooves 430 in it, so that there is a free passage of air through the sleeve in the body (please read the back first and pay attention Item again ^ (ten pages): installed < book-line. 5fc scale of the original paper, the use rate of the middle song B home sample (CHS) T 4 specifications (210X297 g *) 205002 Λ 6 Β6 Central Ministry of Economic Affairs and standard work Printed by the anti-crime cooperative. 5. Description of the invention (). As will now be explained, the sleeve 420 can be fixed in place by keeping the membrane H 440-20 attached to the top of the main body 400 in contact. Thus, the sleeve 420 It can be effectively hung from the top of the main body. It includes a rigid disc-shaped portion 441, a flexible and generally cylindrical wall section 445 and a rigid joint section 447 shaped flexible diaphragm 440 The end shown in FIG. 4 is assembled around the intentionally manufactured groove 450 in the sleeve by a quick press assembly method. Another molded lip 470 on the diaphragm can provide a well-built fit for one end of the compression spring 460. The compression spring is positioned so that it can act freely on the sleeve. The other end of the compression spring is positioned in the insert 480, which is mainly a cylindrical flange, installed in the top portion of the main body 400 by the annular stern portion 481. This insert contains a groove 490, and the disc-shaped portion of the flexible diaphragm 440 is pressed and fitted in this groove 490. The connection between the diaphragm joint portion 447 and the inner sleeve groove 450 is installed as an airtight type, and the shape of the top surface of the sleeve 42 2 is consistent with the inside of the membrane M, so that in the rest position of the inhaler, The two surfaces are very similar, and the enclosed space between the two surfaces is extremely small. The cylindrical insert 480 is fixed in place by the end cap 407 fitted in the main bet of the device. This method can form a chamber 590 between each intake groove 420 and the hard member 441 of the diaphragm. The chamber is provided with one or more air passages so that air can pass from the air inlet groove 420 to the sealing member 405. The hard disc-shaped portion 441 of the diaphragm also contains a small valve port 495. Under normal circumstances, this small valve port 4 95 is pseudo-valve gasket installed in the blade 550 pivotally connected to the insert 480 (Turntable) Covered. The blade 55 0 in its rest position can connect the chamber 5 9 0 to the air inlet 4 2 0 (please read the back first and y notes Λ-fill (: -page) This paper size uses the middle song " Standard (CNS) Τ4 specification (210X297 g; ¢) 12 205002 Λ 6 η 6 Ministry of Economic Affairs, Bureau of Economics, Central Engineering Bureau, A, Consumers and Consumers, co-printed by Du. V. Description of invention () The air passages 580 of the sealing parts are separated , So that the leaf Η 550 can be moved from its static position by the pressure drop between the air inlet and the sealing member. When the blade moves to the actuated position, the valve gasket (rotary plate) 540 has fully moved, enough to open the valve Port 495. (The blade $ 50 can be biased and closed by the flexure of a spring. A weight or magnet is not shown in the figure.) As shown in Figure 3, the end of the main body with the pivot 50 Q has A notch part suitable for receiving the cam 5 2 0, combined with the dust cap 510 as a whole to move on the pivot. The notch part additionally contains a similar channel communicating with the inner wall of the main bet 400 The passage of the cam follower 530 extending from the lower edge of the inner sleeve 420 acts on the cam so that when the dust cap is in its closed position The inner sleeve sleeve is driven by the cam follower to its uppermost position. When the anti-eagle cap is turned to its open position, the cam C9T is such that the cam follower can freely move down a full amount The device can activate the device. In its rest position, the dust cap 510 is closed, and the cam follower 5 30 restrains the inner sleeve 4 2 0 at its uppermost position, causing the diaphragm 44 0 and the inner sleeve top The closed space occupied by the surface 422 is the smallest, and the spring 4 6 Q is compressed. The valve port 495 is closed by the valve seal (rotary plate), and the sleeve 420 is free to leave the top of the aerosol can 25 that has been unloaded in this way After the dust cap is opened, the whole cam 520 is turned to make the cam follower 5 3 0 drop by ΑΑ. The inner sleeve is driven downward by the spring 4 6 0. When the inner sleeve moves down, the membrane The closed volume between the Η 44 0 and the inner sleeve increases by a linear equivalent A z A ′, the equivalent A ′ A / is less than or equal to ΑΑ. Due to the valve port
F骓便全 AF will be full A
Th. 先 閲 讀 背. 而 之 注 意 事 項 -ρμ -·. π 本紙張尺度遑用中a Η家楳毕(CNS) Τ4規格(210x297公*) 205002 Λ 6 η 6 經濟部中央櫺準灼Α工消仲合作社印製 五、發明説明（） 4 95為封閉，如此乃在空間600 (請參見第5圖）内産生一低 壓容積或近真空。封閉容積600與大氣壓間之壓力撖差效 應致使内袖套有反抗彈簧作用之傾向。當内袖套下移時， 其會接觸氣溶膠罐25並開始氣溶膠閥（在圖中未表示）之壓 縮。 内袖套之向下移動一直繼缠至彈簧460之壓縮力與壓 力撤差及氣溶劑閥之壓缩生的阻力之間的各力已平衡 為止。該裝置之幾何形致使此項平衡之發生偽 在氣溶劑閥已經充份壓縮足以引動該閥之前。 標準氣溶膠約需20N(牛頓）之力方可予以起動。因此 彈簧4 6 0所提供之力應較大，以大10%至50%者較佳。 同時亦可予安排以使各力之平衡發生在内袖套已接觸 到氣溶膠罐之前，致使彈簧之力傜藉由於壓力微差而在内 袖套上所産生之阻力所平衡。 在病人經由封口件405吸入時，一小量之壓力微差像 跨越葉片55 0産生，而葉H 550乃朝向一端於植軸上 該壓力徹差使葉片從靜止位置移至引動位置。該 氣通道580之設計使在引動位置時，空氣可從進氣口自由 地流至病人。 葉Η 550之移動使閥封墊（轉板）從具閥口 495之密封位 置移開。打開閥口可使空氣進入膜片與内袖套間之間隙 6 0 0 ,致使封閉之空間到逹大氣氣壓。此一情況使作用於 袖套420與容器25上之力産生不平衡現象。袖套及容器如 此乃由彈簧4 60向下驅動，且於病人吸入之同時，導致計 本紙張尺度逍用中8H家準(CNS)T4規格(210x297公龙) 14 Λ 6 Η 6 205002 五、發明説明（） 量劑之經由配與噴嘴55之放洩並洩於封口件内。如此病人 乃可随同藥劑之計量劑fi而吸入空氣。 病人吸入該劑量之後，防塵帽蓋510 #回至其關閉位 置。此一結果可使凸輪520轉動並使凸輪從動件530向上驅 動。此項向上驅動依序又對内袖套産生作用，使其向上移 動，以壓縮彈簧460並封閉膜片與内袖套頂表面4 22之間的 間隙。此一關閉可將空氣驅離該已封閉之空間600 ,而空 氣則傜閥口 4 95洩出，以提起閥.封墊（轉板）540。因閥封墊 (轉板）僅稍徹镅移至其關閉位置，且其對空氣流出該封閉 空間所具之阻力不大。而氣溶膠罐在其本身氣溶膠閥彈簧 之作用下可自由回至靜止位置。 使用時，病人將氣溶膠配與容器装載於主體内。氣溶 膠容器可藉在主體400内例如沿著線條I - I提供一具粗 螺纹之螺釘予以装載。當主體400之一部份己予旋出時， 氣溶膠即可予插入。主體400於是可予復位，以定置内袖 套於該罐之頂端上面，而該裝置已完成使用之準備。如前 所述，該裝置可製成為一密封之單位。 經濟部屮央梂準局员工消费合作杜印製 該裝置可予提供裝置，俥可對使用者或吸入者提供一 調節過之空流。如此，一聲音裝置，例如一簧片可予提供 ,使於吸入之氣流大於一預設之位準（例如每分鐘30至50 公升）時，該聲音装置會發出聲音。該磬皆装置可予裝設 於封口件95中或進氣口 420之下面。其所發出之磬音可警 告病人須以較低之流率吸入。 該裝置亦可另提裝置，以使其在低於某一預定之氣流 本紙尺度逍用中SB家標準(CNS)T4規格(210x297公龙） -15 - Λ 6 Β6 205002 五、發明説明（） 率（例如每分鐘10至30公升）時不會操作。在一實施例中， 葉Η 550或110可由彈簧偏置，致需要一預定之最小氣流， 以便其能移至其引動位置並使閥封墊能打開。 如本發明之第一或第二實施例中所述，配與裝置之主 體以由塑膠，諸如聚丙烯、乙醛或聚苯乙烯所製成者較佳 。不過，其亦可由金屬或其他合適材料製成。 (請先間讀背而之注噫事項典填^ ^頁) 經濟部屮央榀準而员工消"合作社印製 本紙尺Α逍用中a困家標準（CNS) 1Μ規格（210x297公;«：)Th. Read the back first. And the precautions -ρμ-·. Π This paper is used in standard a Η 極 楳 Bi (CNS) Τ4 specifications (210x297 g *) 205002 Λ 6 η 6 Central Ministry of Economics quasi-burning Printed by Xiaozhong Cooperative V. Description of the invention (4) 4 95 is closed, so that a low-pressure volume or near vacuum is generated in the space 600 (see Figure 5). The pressure difference between the enclosed volume 600 and atmospheric pressure should cause the inner sleeve to have a tendency to resist the spring action. When the inner sleeve moves down, it will contact the aerosol can 25 and start the compression of the aerosol valve (not shown in the figure). The downward movement of the inner sleeve continues until the forces between the compression force of the spring 460 and the pressure difference and the resistance generated by the compression of the aerosol valve have been balanced. The geometry of the device causes this balance to be false before the aerosol valve has been fully compressed enough to actuate the valve. Standard aerosol requires about 20N (Newton) to start. Therefore, the force provided by the spring 460 should be greater, with a greater 10% to 50% being better. It can also be arranged so that the balance of the forces occurs before the inner sleeve has contacted the aerosol can, causing the force of the spring to be balanced by the resistance generated on the inner sleeve due to the slight difference in pressure. When the patient inhales through the sealing member 405, a small amount of pressure differential image is generated across the blade 550, and the blade H 550 is directed toward one end on the implant axis. This pressure difference causes the blade to move from the rest position to the actuation position. The design of the air channel 580 allows air to flow freely from the air inlet to the patient in the activated position. The movement of leaf Η 550 moves the valve gasket (rotary plate) away from the sealed position with valve port 495. Opening the valve port allows air to enter the gap 600 between the diaphragm and the inner sleeve, causing the enclosed space to reach atmospheric pressure. This situation creates an unbalanced force on the sleeve 420 and the container 25. The sleeve and the container are driven downward by the spring 4 60, and at the same time as the patient inhales, it leads to the use of notebook paper in the 8H family standard (CNS) T4 specification (210x297 male dragon) 14 Λ 6 Η 6 205002 V. DESCRIPTION OF THE INVENTION () The dosage is discharged through the dispensing nozzle 55 and discharged into the sealing member. In this way, the patient can inhale air along with the metered dose fi of the medicament. After the patient inhales the dose, the dust cap 510 # returns to its closed position. As a result, the cam 520 can be rotated and the cam follower 530 can be driven upward. This upward drive sequentially acts on the inner sleeve, moving it upward, to compress the spring 460 and close the gap between the diaphragm and the top surface 4 22 of the inner sleeve. This closing can drive the air away from the closed space 600, and the air is discharged from the valve port 4 95 to lift the valve. Seal (turning plate) 540. Because the valve gasket (rotary plate) moves only slightly to its closed position, and it has little resistance to air flowing out of the enclosed space. The aerosol can is free to return to the rest position under the action of its aerosol valve spring. During use, the patient loads the aerosol with the container into the body. The aerosol container can be loaded by providing a screw with a thick thread in the main body 400, for example, along the line I-I. When a part of the main body 400 has been unscrewed, the aerosol can be inserted. The main body 400 can then be reset to set the inner sleeve over the top of the can, and the device is ready for use. As mentioned earlier, the device can be made as a sealed unit. Printed by the Consumer Cooperation Department of the Ministry of Economic Affairs of the Ministry of Economic Affairs. The device can be provided to provide a regulated air flow for users or inhalers. In this way, a sound device, such as a reed, can be provided so that the sound device emits sound when the inhaled airflow is greater than a predetermined level (for example, 30 to 50 liters per minute). The chime device can be installed in the sealing member 95 or under the air inlet 420. The chirping sound can warn patients to inhale at a lower flow rate. The device can also mention another device, so that it can be used below the SB home standard (CNS) T4 specification (210x297 male dragon) below a certain predetermined airflow standard -15-Λ 6 Β6 205002 V. Description of invention () It will not operate at a rate (eg 10 to 30 litres per minute). In one embodiment, the leaf H 550 or 110 may be biased by a spring, so that a predetermined minimum air flow is required so that it can be moved to its actuated position and the valve seal can be opened. As described in the first or second embodiment of the present invention, the main body of the dispensing device is preferably made of plastic, such as polypropylene, acetaldehyde, or polystyrene. However, it can also be made of metal or other suitable materials. (Please read the notes on the back of the page to fill in the ^^^ page) The Ministry of Economic Affairs is accurate and the employees are eliminated " Cooperative printed this paper ruler A Xiaozhongzhongjia Standard (CNS) 1Μ specification (210x297; «:)