TW202430221A - 抗體－藥物複合體及其製備方法與用途 - Google Patents

抗體－藥物複合體及其製備方法與用途 Download PDF

Info

Publication number
TW202430221A
TW202430221A TW112139754A TW112139754A TW202430221A TW 202430221 A TW202430221 A TW 202430221A TW 112139754 A TW112139754 A TW 112139754A TW 112139754 A TW112139754 A TW 112139754A TW 202430221 A TW202430221 A TW 202430221A
Authority
TW
Taiwan
Prior art keywords
amino acid
seq
acid sequence
antibody
heavy chain
Prior art date
Application number
TW112139754A
Other languages
English (en)
Chinese (zh)
Inventor
遜 孟
淑惠 劉
史靜
翁煒寧
Original Assignee
中國商普眾發現醫藥科技（上海）有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 中國商普眾發現醫藥科技（上海）有限公司 filed Critical 中國商普眾發現醫藥科技（上海）有限公司
Publication of TW202430221A publication Critical patent/TW202430221A/zh

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/68037—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a camptothecin [CPT] or derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2884—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD44
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • C07K16/3092—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated mucins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW112139754A 2022-10-19 2023-10-18 抗體－藥物複合體及其製備方法與用途 TW202430221A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN2022126273 2022-10-19
WOPCT/CN2022/126273 2022-10-19
WOPCT/CN2023/118363 2023-09-12
CN2023118363 2023-09-12

Publications (1)

Publication Number Publication Date
TW202430221A true TW202430221A (zh) 2024-08-01

Family

ID=90737003

Family Applications (1)

Application Number Title Priority Date Filing Date
TW112139754A TW202430221A (zh) 2022-10-19 2023-10-18 抗體－藥物複合體及其製備方法與用途

Country Status (9)

Country Link
EP (1) EP4605015A1 (https=)
JP (1) JP2025535447A (https=)
KR (1) KR20250080903A (https=)
CN (1) CN120091834A (https=)
AU (1) AU2023362056A1 (https=)
IL (1) IL320035A (https=)
MX (1) MX2025004492A (https=)
TW (1) TW202430221A (https=)
WO (1) WO2024083161A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2026037321A1 (en) * 2024-08-13 2026-02-19 Lepu Biopharma Co., Ltd. Compounds, compositions and methods
CN120369658B (zh) * 2025-06-26 2025-08-29 凯莱英生命科学技术(天津)有限公司 测定抗体偶联药物中毒素连接子的消光系数的方法及检测抗体偶联药物中药物抗体偶联比的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7381478B2 (ja) * 2017-10-23 2023-11-15 マブリンク ビオシオンス 単一分子量ポリサルコシンを含むリガンド－薬物－複合体
WO2020132190A1 (en) * 2018-12-21 2020-06-25 Multitude Inc. Antibodies specific to muc18
AU2020216780B2 (en) * 2019-01-28 2025-05-08 Multitude Therapeutics Inc. Antibodies specific to CD44
KR20220024106A (ko) * 2019-05-20 2022-03-03 노파르티스 아게 Mcl-1 억제제 항체-약물 접합체 및 사용 방법
AU2021284401A1 (en) * 2020-06-05 2023-01-05 Eisai R&D Management Co., Ltd. Anti-BCMA antibody-drug conjugates and methods of use

Also Published As

Publication number Publication date
AU2023362056A1 (en) 2025-04-24
WO2024083161A1 (en) 2024-04-25
EP4605015A1 (en) 2025-08-27
CN120091834A (zh) 2025-06-03
IL320035A (en) 2025-06-01
JP2025535447A (ja) 2025-10-24
MX2025004492A (es) 2025-05-02
KR20250080903A (ko) 2025-06-05

Similar Documents

Publication Publication Date Title
AU2020338481B2 (en) Targeted dendrimer conjugates
BR112020005212A2 (pt) conjugado de anticorpo, kit, composição farmacêutica, e, métodos de tratamento ou prevenção e de diagnóstico de uma doença ou condição.
WO2023102875A1 (en) Anti-cdh6 antibody drug conjugate
TW202430221A (zh) 抗體－藥物複合體及其製備方法與用途
WO2023104188A1 (en) Anti-cdh6 antibodies and antibody-drug conjugates thereof
US12496354B2 (en) CD142 antibodies, antibody-drug conjugates, preparations and uses thereof
EP4606822A1 (en) Antibody-drug conjugate, preparation method therefor and use thereof in resisting tumors
KR20260016950A (ko) 항체 및 이의 항체 약물 접합체
CN119053607A (zh) 喜树碱类化合物及其偶联物、其制备方法和用途
EA053275B1 (ru) Конъюгат антитело-лекарственное средство, способ его получения и применение
US12419964B2 (en) Antibody drug conjugate (ADC) targeting Nectin 4 and comprising an exatecan payload
EP4534102A1 (en) Antibody drug conjugate (adc) targeting nectin 4 and comprising an exatecan payload
EA052998B1 (ru) Конъюгат антитело-лекарственное средство, способ его получения и его противоопухолевое применение
CA3270684A1 (en) Antibody-drug conjugate, perparation method therefor, and anti-tumor use thereof
WO2025026338A1 (zh) 具有高药物负载的抗体-药物缀合物及其用途
WO2025206085A1 (ja) 癌の治療及び／又は予防用医薬組成物
TW202515913A (zh) Nectin-4抗體及抗體藥物結合物
CN121494985A (zh) 靶向Trop2/EpCAM的双特异性抗体、抗体偶联药物及其制备方法与应用
BR122021021119B1 (pt) Anticorpos anti-egfr, conjugado anticorpo-fármaco, composição farmacêutica, usos dos mesmos para tratar câncer e inibir ou diminuir o crescimento de tumor sólido
BR112016021717B1 (pt) Anticorpos anti-egfr, conjugado anticorpo-fármaco, composição farmacêutica, usos dos mesmos para tratar câncer e inibir ou diminuir o crescimento de tumor sólido
BR122024015645A2 (pt) Anticorpos anti-egfr, conjugado anticorpo-fármaco, composição farmacêutica, usos dos mesmos para tratar câncer e inibir ou diminuir o crescimento de tumor sólido, bem como ácido nucleico, vetor e célula hospedeira
BR122024015645B1 (pt) Anticorpo anti-egfr, conjugado anticorpo-fármaco que compreende o dito anticorpo, composição farmacêutica compreendendo os mesmos, usos dos mesmos para tratar câncer e inibir ou diminuir o crescimento de tumor sólido