TW202416909A - Assembleable artificial bone plate and artificial bone plate unit - Google Patents

Abstract

The present invention relates to an artificial bone plate unit and an assembleable artificial bone plate. The artificial bone plate unit has a plate body. The plate body has two opposite side surfaces and an outer ring wall. The outer ring wall is connected between the two side surfaces. A plurality of coupling columns and a plurality of coupling grooves are formed on the plate body along the outer ring wall, and the shape of the coupling column corresponds to the shape of the coupling groove. A plurality of drug cavities are formed inside the artificial bone plate unit, and a plurality of drug release openings are formed on the artificial bone plate unit. The drug release openings are in communication with the drug cavities. Through the drug cavities and the drug release openings, the artificial bone plate unit can facilitate wound healing by slowly releasing drugs after surgery. By assembling a plurality of small artificial bone plate units and bending them into a large assembleable artificial bone plate having a desired shape, it is able to avoid material waste caused by cutting expensive medical materials.

Description

Combined bone-replenishing tablets and bone-replenishing tablet units

The present invention relates to a medical implant, in particular to a combined bone graft and a bone graft unit for repairing cranial bone defects.

When a patient has a large area of skull removed due to trauma or brain surgery, the defective part of the skull needs to be repaired and shaped in subsequent treatment to avoid sequelae of fragile brain tissue due to lack of bone protection. The existing skull repair technology first uses a cutting method to cut a whole piece of metal or polymer material into a bone patch that matches the defective part, and then fix the shaped bone patch to the skull through surgery.

However, since the shape of the skull is a curved surface, a large amount of material often needs to be removed when using the entire piece of material for cutting. Therefore, the bone grafts of the prior art not only waste materials, but also take a lot of time to make.

Therefore, the bone-replenishing tablets of the prior art need to be improved.

In view of the above-mentioned shortcomings and deficiencies of the prior art, the present invention provides a bone-replenishing tablet to save materials and production time.

In order to achieve the above-mentioned creative purpose, the technical means adopted by this creation is to design a bone-replenishing tablet unit, which is a plate body, and the plate body includes two opposite side surfaces and an outer ring wall surface, and the outer ring wall surface is connected between the two side surfaces; a plurality of binding columns and a plurality of binding grooves are formed on the plate body along the outer ring wall surface, and the shapes of the plurality of binding columns correspond to the shapes of the plurality of binding grooves; a plurality of drug cavities are formed inside the bone-replenishing tablet unit, and a plurality of drug release openings are formed on the bone-replenishing tablet unit, and the drug release openings are connected to the drug cavities.

In order to achieve the above-mentioned creative purpose, the technical means adopted by this creation is to design a combined bone-repairing piece, which is a bendable plate. The combined bone-repairing piece includes a plurality of the aforementioned bone-repairing piece units, and the bone-repairing piece units are connected to each other; in any two of the mutually connected bone-repairing piece units, at least one of the combining columns of one of the bone-repairing piece units is inserted into at least one of the combining grooves of the other bone-repairing piece units.

In order to achieve the above-mentioned creative purpose, the technical means adopted by this creation is to design a bone-replenishing tablet unit, which is a plate body, and the plate body includes two opposite side surfaces and an outer ring wall surface, and the outer ring wall surface is connected between the two side surfaces; a plurality of binding columns are formed on the plate body along the outer ring wall surface; a plurality of drug cavities are formed inside the bone-replenishing tablet unit, and a plurality of drug release openings are formed on the bone-replenishing tablet unit, and the drug release openings are respectively connected to the drug cavities.

In order to achieve the above-mentioned creative purpose, the technical means adopted by this creation is to design a bone-replenishing tablet unit, which is a plate body, and the plate body includes two opposite side surfaces and an outer ring wall surface, and the outer ring wall surface is connected between the two side surfaces; a plurality of coupling grooves are formed on the plate body along the outer ring wall surface; a plurality of drug cavities are formed inside the bone-replenishing tablet unit, and a plurality of drug release openings are formed on the bone-replenishing tablet unit, and the drug release openings are respectively connected to the drug cavities.

The advantage of the invention is that, by designing a plate-shaped bone-repairing piece unit, each bone-repairing piece unit is formed with a plurality of coupling columns and a plurality of coupling grooves along its outer ring wall surface, and the bone-repairing piece units can be connected to each other by the coupling columns and coupling grooves at the edges to form a large assembled bone-repairing piece; when making a bone-repairing piece for a patient's damaged skull, the invention can combine and bend a large assembled bone-repairing piece that matches the shape of the skull defect, thereby avoiding the waste of materials caused by cutting expensive medical materials and saving manufacturing time.

In addition, the bone plate unit can promote wound healing by slowly releasing drugs after surgery through the drug cavity and the drug release opening. To be precise, the drug cavity can be filled with drugs before surgery, and then after the bone plate unit is placed in the human body, the drugs will be slowly released through the drug release opening.

Furthermore, in the bone-replenishing tablet unit, the maximum cross-sectional area of each drug cavity is greater than the maximum cross-sectional area of the corresponding drug release opening; and the normal direction of the cross section with the maximum cross-sectional area in each drug cavity is parallel to an opening direction of the corresponding drug release opening.

Furthermore, the bone-replenishing tablet unit comprises a plurality of drug release channels, and the drug release channels are respectively connected to the drug release openings and the drug cavities.

Furthermore, in the bone-replenishing tablet unit, the shape of each drug cavity in its longitudinal cross section is circular, elliptical, oval or triangular; the normal direction of the longitudinal cross section of each drug cavity is parallel to an opening direction of the corresponding drug release opening.

Furthermore, in the bone-replenishing tablet unit, the cross-sectional area of each drug cavity increases as the cross section moves away from the corresponding drug release opening; and the normal direction of the cross section is parallel to an opening direction of the corresponding drug release opening.

Furthermore, in the bone-repairing piece unit, the plurality of coupling posts and the plurality of coupling grooves are formed on the outer ring wall surface of the plate body.

Furthermore, in the bone-repairing unit, the plate body is an N-polygon so that the outer ring wall is formed with N connecting surfaces; the number of the coupling columns is N, which are respectively formed on the N connecting surfaces; the number of the coupling grooves is N, which are respectively formed on the N connecting surfaces; wherein N is an integer greater than 2.

Furthermore, in the bone-repairing piece unit, the plurality of coupling posts are formed on one of the side surfaces of the plate body; and the plurality of coupling grooves penetrate through the two side surfaces of the bone-repairing piece unit.

Furthermore, in the bone-repairing piece unit, the plurality of coupling posts are respectively formed on the two side surfaces of the plate body; and the plurality of coupling grooves penetrate the two side surfaces of the bone-repairing piece unit.

Furthermore, in the bone-repairing unit, the plate body is formed with a plurality of screw holes through the two side surfaces, and the plurality of screw holes are arranged along the outer ring wall of the plate body.

Furthermore, in the bone-repairing unit, the plate body is a polygon so that the outer ring wall has a plurality of corners, and each of the coupling columns and each of the coupling grooves is adjacent to one of the corners.

Furthermore, in the bone-repairing unit, the plate body is an N-polygon so that the outer ring wall is formed with N connecting surfaces; the number of the coupling columns and the number of the coupling grooves are N in total; wherein N is an integer greater than 2.

Furthermore, the bone-replenishing piece unit has a thickness of less than 1 mm.

Furthermore, the bone-replenishing sheet unit is made of titanium, titanium-hexa-aluminum-tetra-vanadium alloy, 316L stainless steel, polyetheretherketone, or aluminum.

Furthermore, in the bone-replenishing sheet unit, the plate body has a plurality of drug pins formed on one of the side surfaces, each of the drug pins forms one of the drug cavities, and each of the drug pins has a drug release opening formed at the end thereof, and one of the drug release openings is connected to one of the drug cavities.

The following is a combination of diagrams and preferred embodiments of the present invention to further illustrate the technical means used by the present invention to achieve the intended purpose of the invention.

Please refer to Figures 1 to 3, the bone-replenishing unit of the invention includes a plate, a plurality of binding posts 30, a plurality of binding grooves 40, a plurality of drug cavities 50 and a plurality of drug release openings 60. The plate includes two opposite side surfaces 10 and an outer ring wall 20, and the outer ring wall 20 is connected between the two side surfaces 10.

A plurality of coupling posts 30 and a plurality of coupling grooves 40 are formed on the plate along the outer ring wall 20. The shapes of the coupling posts 30 correspond to the shapes of the coupling grooves 40. Thus, two bone-repairing sheet units of the present invention can be assembled by fitting the coupling posts 30 and the coupling grooves 40 into each other.

The drug cavity 50 (as shown in FIG3 ) is formed inside the bone-replenishing tablet unit. The drug release opening 60 is formed on the bone-replenishing tablet unit and is connected to the drug cavity 50, whereby the drug can be pre-filled into the drug cavity 50 before surgery, and then after the bone-replenishing tablet unit is placed in the human body, the drug in the drug cavity 50 will be slowly released.

In a preferred embodiment, the drug cavity 50 is formed inside the plate body and the binding column 30; the drug release opening 60 is formed on both side surfaces 10, the outer ring wall surface 20 and all outer surfaces of the binding column 30. In other words, the drug release opening 60 and the drug cavity 50 are arranged on all outer surfaces of the bone filling piece unit. In another preferred embodiment, the drug release opening 60 and the drug cavity 50 are only arranged on the plate body. Preferably, the drug cavity 50 and the drug release opening 60 are formed together by an etching process.

In addition, preferably, the bone-replenishing tablet unit has a plurality of drug release channels 70. The drug release channels 70 connect the drug release openings 60 and the drug cavities 50. In other words, the drug release openings 60 and the drug cavities 50 are connected through the drug release channels 70. In another preferred embodiment, the drug release channels 70 are omitted, and the drug release openings 60 and the drug cavities 50 are directly connected.

3 to 8 , the detailed size and shape of the drug cavity 50 are further described with reference to the cross-section and longitudinal section of the drug cavity 50. The cross-section normal direction of each drug cavity 50 is parallel to the opening direction of the corresponding drug release opening 60, and the longitudinal cross-section normal direction of each drug cavity 50 is perpendicular to the opening direction of the corresponding drug release opening 60.

In a preferred embodiment, the maximum cross-sectional area of each drug cavity 50 is greater than the maximum cross-sectional area of the corresponding drug release opening 60, so that the drug in the drug cavity 50 can be slowly released to allow the drug to be released for a longer time. The longitudinal cross-sectional shape of the drug cavity 50 can be circular (as shown in FIGS. 3 and 4 ), elliptical (as shown in FIGS. 5 and 6 ), or oval.

7 and 8, in another preferred embodiment, the cross-sectional area of each drug cavity 50 increases as the cross-sectional area X-X moves away from the corresponding drug release opening 60. In this particular embodiment, the shape of each drug cavity 50 in the longitudinal cross section is preferably a triangle.

Please refer to FIG. 1 and FIG. 2. Preferably, the aforementioned plurality of coupling posts 30 and the plurality of coupling grooves 40 are formed on the outer annular wall surface 20 of the plate body in this embodiment. Thus, after the plurality of bone-repairing units are connected and combined into a bone-repairing piece assembly through the coupling posts 30 and the coupling grooves 40 of the outer annular wall surface 20, the surface of the bone-repairing piece assembly will not have obvious height differences (as shown in FIG. 21). However, the positions of the plurality of coupling posts and the plurality of coupling grooves are not limited to this. As long as the plurality of coupling posts and the plurality of coupling grooves are arranged along the outer annular wall surface 20 of the plate body, the plurality of bone-repairing pieces will not have obvious height differences (as shown in FIG. 21). The annular wall surface can be formed. The so-called forming along the outer annular wall surface of the plate body is not limited to being formed on the outer annular wall surface, as long as it is extended or arranged around the position along the outer annular wall surface. In other words, a plurality of coupling columns and a plurality of coupling grooves can be formed on the outer annular wall surface 20 as in the present embodiment (as shown in FIG. 1 ), or can also be formed along the side surface 10F of the plate body near the edge of the outer annular wall surface 20F as in the seventh embodiment of the present invention (as shown in FIG. 17 ).

In the present embodiment, when the plate body is an N-polygon (N is an integer greater than 2), the outer ring wall is formed with N connecting surfaces; the number of coupling posts is N, which are respectively formed on the N connecting surfaces; the number of coupling grooves is N, which are respectively formed on the N connecting surfaces. In simple terms, when the plate body is a polygon, each connecting surface of the polygon has a coupling post and a coupling groove; specifically, N in the present embodiment is equal to six, that is, the plate body of the present embodiment is a regular hexagon and the outer ring wall 20 is formed. The polygonal plate has six connecting surfaces 21; the number of the coupling posts 30 is six, which are formed on the six connecting surfaces 21 respectively; the number of the coupling grooves 40 is six, which are formed on the six connecting surfaces 21 respectively, but the number of coupling posts and coupling grooves of each connecting surface of the polygonal plate is not limited thereto. For example, in the second embodiment of the present invention (as shown in FIG. 9 ), part of the connecting surface 21A has two coupling posts 30A but no coupling grooves, and part of the connecting surface 21A has two coupling grooves 40A but no coupling posts, and this is also acceptable.

The shape of the aforementioned binding column 30 is cylindrical in the present embodiment, and the shape of the binding groove 40 is a circular groove corresponding to the binding column 30, but the shape of the binding column can also be formed into a square column-shaped binding column 30B (as shown in FIG. 11), or a triangular column-shaped binding column 30C (as shown in FIG. 12), or a pentagonal column-shaped binding column 30D (as shown in FIG. 13) and other columns of various shapes, and the binding groove can also correspond to various binding columns to form a square binding groove 40B (as shown in FIG. 11), a triangular binding groove 40C (as shown in FIG. 12), or a pentagonal binding groove 40D (as shown in FIG. 13) and other grooves of various shapes.

In other preferred embodiments, a circular binding bead 50E is connected to the top of the binding column 30E (as shown in FIG. 10 ), and the width of the binding bead 50E is greater than the width of the binding column 30E, and a circular binding bead groove 60E is connected to the bottom of the groove of the binding groove 40E, and the width of the binding bead groove 60E corresponds to the width of the binding bead 50E. Thus, when connecting different bone-repairing sheet units, the binding bead 50E can be pressed against the binding groove 40E by pressure, and the binding groove 40E can be elastically deformed and expanded, so that the binding bead 50E penetrates the binding groove 40E and is engaged in the binding bead groove 60E, thereby strengthening the binding force to prevent the bone-repairing sheet unit from being easily pulled out and separated after the connection.

Please refer to Figures 14 and 15. The specific structure of the seventh embodiment of the bone-replenishing sheet unit of the present invention is roughly the same as the first embodiment. The difference is that in the seventh embodiment, a plurality of drug plugs 80H are formed on one side surface 10H of the plate body. Each drug plug 80H is formed with one of the drug cavities 50H, and the end of each drug plug 80H is formed with one of the drug release openings 60H. The drug release openings 60H on each drug plug 80H are connected to the drug cavity 50H. The drug plugs 80H are preferably microtubes formed by a special chemical process, and are preferably densely arranged on the side surface 10H.

Please refer to FIG. 16 . The combined bone-repairing piece of the present invention is a bendable plate body. The combined bone-repairing piece includes a plurality of bone-repairing piece units P, which are interconnected. In any two interconnected bone-repairing piece units P, at least one coupling column 30 of one bone-repairing piece unit P is penetrated into at least one coupling groove 40 of another bone-repairing piece unit P. In the present embodiment, the bone-repairing piece unit P is formed by the coupling column 30 and the coupling groove 40 located on the outer annular wall surface 20 of the plate body being penetrated and connected to form the combined bone-repairing unit. Specifically, the combined bone-repairing piece unit is formed by connecting a plurality of bone-repairing piece units P of the first embodiment. However, the combined bone-repairing piece may also be formed by connecting a plurality of bone-repairing pieces of the aforementioned other embodiments.

Please refer to FIG. 17 and FIG. 18 , the eighth embodiment of the bone-replenishing piece unit of the present invention is substantially the same as the first embodiment, and the difference lies in the forming positions of the plurality of binding posts 30F and the plurality of binding grooves 40F.

A plurality of coupling columns 30F are formed on one side surface 10F of the plate body of the bone-repairing piece unit; a plurality of coupling grooves 40F penetrate the two side surfaces of the bone-repairing piece unit; in the present embodiment, a plurality of screw holes 11F are formed through the two side surfaces 10F of the plate body, and the plurality of screw holes 11F are arranged along the outer annular wall surface 20F of the plate body, but the positions of the screw holes 11F penetrating the two side surfaces 10F of the plate body are not limited thereto, and the plate body may even be free of screw holes.

In the present embodiment, the plate body is a polygon and its outer annular wall surface 20F has a plurality of corners 22F, each coupling column 30F and each coupling groove 40F is adjacent to one of the corners 22F. Specifically, the plate body is a hexagon, and the corners 22F are located at each turning point of the outer annular wall surface 20F. The positions of the coupling columns 30F and the coupling grooves 40F are both adjacent to the turning points, but the positions of the coupling columns and the coupling grooves are not limited thereto. For example, they may also be arranged near the center of two adjacent corners 22F.

In the present embodiment, the plate body is an N-gon, wherein N>2, and N is an integer (N is an integer greater than 2), so that the outer annular wall surface 20F is formed with N connecting surfaces; the number of coupling columns 30F and the number of coupling grooves 40F are N in total. Specifically, N is equal to six, and the plate body is a hexagon, so that the outer annular wall surface 20F is formed with six connecting surfaces 21F; the number of coupling columns 30F and the number of coupling grooves 40F are six in total, namely three coupling columns 30F and three coupling grooves 40F, so that each connecting surface 21F of the polygonal plate body can be stably connected to the connected plate body, but the total number of coupling columns and the number of coupling grooves is not limited thereto. For example, a total of twelve coupling columns and coupling grooves can also be provided in the hexagonal plate body.

Please refer to Figures 19 and 20. The ninth embodiment of the bone-replenishing piece unit of the present invention is substantially the same as the aforementioned eighth embodiment, except that a plurality of combining columns 30G are respectively formed on both side surfaces 10G of the plate body; therefore, the plurality of combining columns of the plate body may be formed on only one side surface of the plate body, or symmetrically formed on both side surfaces of the plate body (that is, equivalent to all combining columns penetrating the plate body up and down), or asymmetrically formed on both side surfaces of the plate body (that is, equivalent to some combining columns penetrating the plate body up and down, some combining columns are formed on one side surface of the plate body, and some combining columns are formed on the other side surface of the plate body), or all of the above are possible.

In the eighth and ninth embodiments of the aforementioned bone-repairing piece unit, the distance between the two sides of the plate body is defined as the plate body thickness, and the plate body thickness is less than 1 mm, but the plate body thickness of the bone-repairing piece unit is not limited to this. As long as the coupling columns and coupling grooves of the bone-repairing piece unit are formed on the sides of the plate body, the plate body can be bent and deformed according to the needs of the operation.

In all the above embodiments of the bone-replenishing sheet unit, the plate material can be any one of titanium, titanium-6-aluminum-4-vanadium alloy (Ti-6Al-4V), polyetheretherketone (PEEK), 316L stainless steel, etc., which has excellent biocompatibility and mechanical strength, or the material of the bone-replenishing sheet unit can also be aluminum, which is light and cheap. In addition, the bone-replenishing sheet unit in all the above embodiments has a drug cavity 50 and a drug release channel 60 to release the drug.

Please refer to Figure 21. The second embodiment of the combined bone-repairing piece of the present invention is substantially the same as the first embodiment, except that the plurality of coupling columns and the plurality of coupling grooves of the bone-repairing piece unit used in the present embodiment are formed on the side surfaces of each plate, and therefore the bone-repairing piece units are connected in a manner of overlapping edges; wherein the bone-repairing piece unit P1 corresponds to the ninth embodiment of the bone-repairing piece unit of the present invention (as shown in Figure 19), the bone-repairing piece unit P2 corresponds to the eighth embodiment of the bone-repairing piece unit of the present invention (as shown in Figure 17), and the bone-repairing piece unit P3 is substantially the same as the eighth embodiment of the bone-repairing piece unit of the present invention, but one of the coupling columns P4 is higher than the other coupling columns to facilitate the connection of the bone-repairing piece unit P2.

When the invention is used, a plurality of small bone-repairing sheet units are connected and bent to form a large assembled bone-repairing sheet whose shape corresponds to the skull defect. When the assembled bone-repairing sheet belongs to the second embodiment of the assembled bone-repairing sheet of the invention (as shown in FIG. 21 ), the edge of the assembled bone-repairing sheet can overlap and cover the skull surface, and the bolts can penetrate the bone-repairing sheet to form a large assembled bone-repairing sheet. The bone patch is fixed to the skull by screwing the screw holes of the component into the skull; and when the combined bone patch is in the form of the first embodiment of the combined bone patch of the present invention (as shown in FIG16 ), the edge of the combined bone patch is trimmed as needed, and then the combined bone patch is embedded into the defective part of the skull, and the combined bone patch is fixed to the skull in other ways.

The above is only the best embodiment of the present invention and does not constitute any form of limitation on the present invention. Although the present invention has been disclosed as the best embodiment as above, it is not used to limit the present invention. Any person with ordinary knowledge in the relevant technical field can make some changes or modifications to the technical contents disclosed above into equivalent embodiments within the scope of the technical solution of the present invention. However, any simple modification, equivalent change and modification made to the above embodiments based on the technical essence of the present invention without departing from the content of the technical solution of the present invention are still within the scope of the technical solution of the present invention.

10: Side surface 20: Outer ring wall surface 21: Connection surface 30: Binding column 40: Binding groove 21A: Connection surface 30A: Binding column 40A: Binding groove 30B: Binding column 40B: Binding groove 30C: Binding column 40C: Binding groove 30D: Binding column 40D: Binding groove 30E: Binding column 40E: Binding groove 50E: Binding bead 60E: Binding bead groove 10F: Side surface 11F: Screw hole 20F: Outer ring wall surface 21F: Connection surface 22F: Corner 30F: Binding column 40F: Binding groove 30G: Binding column 50: Drug cavity 60: drug release opening 70: drug release channel P: bone-replenishing tablet unit P1: bone-replenishing tablet unit P2: bone-replenishing tablet unit P3: bone-replenishing tablet unit P4: binding column

Figure 1 is a three-dimensional external view of the first embodiment of the bone-replenishing sheet unit of the present invention. Figure 2 is a top view schematic diagram of the first embodiment of the bone-replenishing sheet unit of the present invention. Figure 3 is a partial enlarged longitudinal section of the first embodiment of the bone-replenishing sheet unit of the present invention. Figures 4 to 8 are partial enlarged longitudinal sections of other embodiments of the bone-replenishing sheet unit of the present invention. Figure 9 is a three-dimensional external view of the second embodiment of the bone-replenishing sheet unit of the present invention. Figure 10 is a three-dimensional external view of the third embodiment of the bone-replenishing sheet unit of the present invention. Figure 11 is a three-dimensional external view of the fourth embodiment of the bone-replenishing sheet unit of the present invention. Figure 12 is a three-dimensional external view of the fifth embodiment of the bone-replenishing sheet unit of the present invention. Figure 13 is a three-dimensional external view of the sixth embodiment of the bone-replenishing sheet unit of the present invention. Figure 14 is a three-dimensional external view of the seventh embodiment of the bone-replenishing sheet unit of the present invention. Figure 15 is a longitudinal cross-sectional view of the seventh embodiment of the bone-replenishing sheet unit of the present invention. Figure 16 is a three-dimensional external view of the first embodiment of the combined bone-replenishing sheet of the present invention. Figure 17 is a three-dimensional external view of the eighth embodiment of the bone-replenishing sheet unit of the present invention. Figure 18 is another three-dimensional external view of the eighth embodiment of the bone-replenishing sheet unit of the present invention. Figure 19 is a three-dimensional external view of the ninth embodiment of the bone-replenishing sheet unit of the present invention. Figure 20 is another three-dimensional external view of the ninth embodiment of the bone-replenishing sheet unit of the present invention. Figure 21 is a three-dimensional external view of the second embodiment of the combined bone-replenishing tablet of the present invention.

P: Bone-tonifying tablets unit

60: Drug release opening

Claims (18)

A bone-replenishing tablet unit is a plate body, which includes two opposite side surfaces and an outer ring wall surface, and the outer ring wall surface is connected between the two side surfaces; a plurality of binding columns and a plurality of binding grooves are formed on the plate body along the outer ring wall surface, and the shapes of the plurality of binding columns correspond to the shapes of the plurality of binding grooves; a plurality of drug cavities are formed inside the bone-replenishing tablet unit, and a plurality of drug release openings are formed on the bone-replenishing tablet unit, and the drug release openings are connected to the drug cavities. A bone-replenishing tablet unit as described in claim 1, wherein the maximum cross-sectional area of each drug cavity is larger than the maximum cross-sectional area of the corresponding drug release opening; and the normal direction of the cross section with the maximum cross-sectional area in each drug cavity is parallel to an opening direction of the corresponding drug release opening. A bone-replenishing tablet unit as described in claim 1, wherein the bone-replenishing tablet unit comprises a plurality of drug release channels, and the drug release channels are respectively connected to the drug release openings and the drug cavities. The bone-replenishing tablet unit as described in claim 1, wherein the shape of each drug cavity in its longitudinal cross-section is circular, elliptical, oval or triangular; and the normal direction of the longitudinal cross-section of each drug cavity is parallel to an opening direction of the corresponding drug release opening. The bone-replenishing tablet unit as described in claim 1, wherein the cross-sectional area of each drug cavity increases as the cross-sectional area moves away from the corresponding drug release opening; and the normal direction of the cross-sectional area is parallel to an opening direction of the corresponding drug release opening. A bone-repairing piece unit as described in any one of claims 1 to 5, wherein the plurality of binding posts and the plurality of binding grooves are formed on the outer ring wall surface of the plate body. A bone-repairing piece unit as described in claim 6, wherein the plate body is an N-polygon so that the outer ring wall is formed with N connecting surfaces; the number of the coupling columns is N, which are respectively formed on the N connecting surfaces; the number of the coupling grooves is N, which are respectively formed on the N connecting surfaces; wherein N>2, and N is an integer. A bone-repairing piece unit as described in any one of claims 1 to 5, wherein the plurality of coupling posts are formed on one of the side surfaces of the plate body; and the plurality of coupling grooves penetrate the two side surfaces of the bone-repairing piece unit. A bone-repairing piece unit as described in any one of claims 1 to 5, wherein the plurality of coupling posts are respectively formed on the two side surfaces of the plate body; and the plurality of coupling grooves penetrate the two side surfaces of the bone-repairing piece unit. As described in claim 8, the bone repair unit, wherein the plate body is formed with a plurality of screw holes through the two side surfaces, and the plurality of screw holes are arranged along the outer ring wall of the plate body. A bone-repairing unit as described in any one of claims 1 to 5, wherein the plate is a polygon so that the outer ring wall has a plurality of corners, and each of the coupling columns and each of the coupling grooves is adjacent to one of the corners. A bone-repairing unit as described in any one of claims 1 to 5, wherein the plate is an N-sided polygon so that the outer ring wall is formed with N connecting surfaces; the number of the binding posts and the number of the binding grooves are N in total; wherein N is an integer greater than 2. A bone-replenishing sheet unit as described in claim 8, wherein the thickness of the bone-replenishing sheet unit is less than 1 mm. A bone-replacing sheet unit as described in any one of claims 1 to 5, wherein the material of the bone-replacing sheet unit comprises titanium, titanium-hexaluminum-tetravanadium alloy, 316L stainless steel, polyetheretherketone, or aluminum. A bone-replenishing piece unit as described in any one of claims 1 to 5, wherein the plate has a plurality of drug pins formed on one of the side surfaces, each of the drug pins has one of the drug cavities formed therein, and each of the drug pins has one of the drug release openings formed at the end thereof, and one of the drug release openings is connected to one of the drug cavities. A combined bone-repairing piece is a bendable plate, comprising a plurality of bone-repairing piece units as described in any one of claims 1 to 15, wherein the bone-repairing piece units are interconnected; in any two of the interconnected bone-repairing piece units, at least one coupling column of one of the bone-repairing piece units is inserted into at least one coupling groove of another of the bone-repairing piece units. A bone-replenishing tablet unit is a plate body, which includes two opposite side surfaces and an outer ring wall surface, and the outer ring wall surface is connected between the two side surfaces; a plurality of binding columns are formed on the plate body along the outer ring wall surface; a plurality of drug cavities are formed inside the bone-replenishing tablet unit, and a plurality of drug release openings are formed on the bone-replenishing tablet unit, and the drug release openings are respectively connected to the drug cavities. A bone-replenishing tablet unit is a plate body, which includes two opposite side surfaces and an outer ring wall surface, and the outer ring wall surface is connected between the two side surfaces; a plurality of coupling grooves are formed on the plate body along the outer ring wall surface; a plurality of drug cavities are formed inside the bone-replenishing tablet unit, and a plurality of drug release openings are formed on the bone-replenishing tablet unit, and the drug release openings are respectively connected to the drug cavities.

Images