TW202412648A - Aerosolisable formulation - Google Patents

Abstract

There is provided an aerosolisable formulation comprising (i) caffeine; (ii) a solvent selected from water, propylene glycol, glycerol and mixtures thereof; and (iii) a buffer comprising benzoic acid and a benzoate.

Description

Atomizable formulations

Invention Field

The present disclosure relates to an atomizable formulation, a method of forming the same, a container containing the same, a device containing the same, and a process for making the same.

Invention Background

Aerosol delivery systems that generate an aerosol for inhalation by a user are known in the art. Such systems typically include an aerosol generator capable of converting an aerosolizable material into an aerosol. In some cases, the aerosol generated is a condensing aerosol, wherein the aerosolizable material is heated to form a vapor, which is then allowed to condense into an aerosol. In other cases, the aerosol generated is an aerosol obtained by atomization of the aerosolizable material. Such atomization may be achieved mechanically, such as by subjecting the aerosolizable material to vibrations so as to form small particulate material entrained in an air stream. Alternatively, such atomization may be achieved electrostatically, or in other ways, such as by the use of pressure, etc.

Depending on the composition of the aerosol material to be provided to the user, it may be preferred to formulate the aerosol material in a certain manner. For example, it may be preferred to formulate the aerosol material so as to produce an aerosol with a specific distribution. It may also be preferred to formulate the aerosol material so as to ensure that the aerosol material meets certain standards of quality, consistency, and the like.

Therefore, it is desirable to provide an aerosolizable material that is formulated so as to be acceptable to the user.

Summary of the invention

In one aspect, a sprayable formulation is provided, comprising (i) caffeine; (ii) a solvent selected from water, propylene glycol, glycerin, and mixtures thereof; and (iii) a buffer comprising benzoic acid and a benzoate salt.

In one aspect, a method of forming an aerosol is provided, the method comprising atomizing an aerosolizable formulation comprising (i) caffeine; (ii) a solvent selected from water, propylene glycol, glycerin, and mixtures thereof; and (iii) a buffer comprising benzoic acid and a benzoate salt.

In one aspect, a drop-in aerosolizable formulation is provided, comprising (a) a container; and (b) an aerosolizable formulation comprising (i) caffeine; (ii) a solvent selected from water, propylene glycol, glycerin, and mixtures thereof; and (iii) a buffer comprising benzoic acid and a benzoate salt.

In one embodiment, an electronic aerosol supply system is provided, comprising: (a) an aerosolizer for aerosolizing a formulation for inhalation by a user of the electronic aerosol supply system; (b) a power supply comprising a battery or battery pack for powering the aerosolizer; (c) an aerosolizable formulation comprising (i) caffeine; (ii) a solvent selected from water, propylene glycol, glycerin, and mixtures thereof; and (iii) propylene glycol; wherein the weight ratio of water to propylene glycol is from 30:70 to 60:40.

In one embodiment, a method for improving the solubility of caffeine in an atomizable formulation is provided, the method comprising the following steps: (a) providing an atomizable material comprising a solvent selected from water, propylene glycol, glycerin, and mixtures thereof; (b) combining caffeine and a buffer solution comprising benzoic acid and a benzoate salt into the atomizable material to provide an atomizable formulation.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

As discussed herein in one aspect, a sprayable formulation is provided that includes (i) caffeine; (ii) a solvent selected from water, propylene glycol, glycerin, and mixtures thereof; and (iii) a buffer solution including benzoic acid and a benzoate salt.

We have found that it is possible to provide an advantageous system comprising caffeine and a buffer comprising benzoic acid and a benzoate, wherein the solvent is selected from water, propylene glycol, glycerol and mixtures thereof. In particular, we have determined that by including in the formulation a buffer comprising benzoic acid and a benzoate, the solubility of caffeine in a nebulizable formulation can be improved compared to a typical system comprising water, propylene glycol and/or glycerol.

For ease of reference, these and further aspects of the present invention are now discussed under the appropriate section headings. However, the teachings under each section are not necessarily limited to each particular section. Caffeine

Caffeine (1,3,7-trimethylpurine-2,6-dione) is a well-known stimulant. About thirty plant species are known to contain caffeine. Common sources are the "beans" (seeds) of the two cultivated coffee plants, Coffea arabica and Coffea canephora, and the cocoa plant, Theobroma cacao; the leaves of the tea plant; and the kola nut.

Caffeine formulations with desirable properties and stimulant effects on users may be provided. In one aspect, caffeine is present in an amount of no more than 20 wt % based on the total weight of the atomizable formulation. In one aspect, caffeine is present in an amount of no more than 15 wt % based on the total weight of the atomizable formulation. In one aspect, caffeine is present in an amount of no more than 10 wt % based on the total weight of the atomizable formulation. In one aspect, caffeine is present in an amount of no more than 5 wt % based on the total weight of the atomizable formulation. In one aspect, caffeine is present in an amount of no more than 3 wt % based on the total weight of the atomizable formulation. In one aspect, caffeine is present in an amount of no more than 2 wt % based on the total weight of the atomizable formulation. In one aspect, caffeine is present in an amount of no greater than 1 wt % based on the total weight of the atomizable formulation.

In one aspect, caffeine is present in an amount of at least 0.01 wt% based on the total weight of the atomizable formulation. In one aspect, caffeine is present in an amount of at least 0.02 wt% based on the total weight of the atomizable formulation. In one aspect, caffeine is present in an amount of at least 0.05 wt% based on the total weight of the atomizable formulation. In one aspect, caffeine is present in an amount of at least 1 wt% based on the total weight of the atomizable formulation. In one aspect, caffeine is present in an amount of at least 1.5 wt% based on the total weight of the atomizable formulation. In one aspect, caffeine is present in an amount of at least 2 wt% based on the total weight of the atomizable formulation. In one aspect, caffeine is present in an amount of at least 3 wt% based on the total weight of the atomizable formulation.

In one aspect, caffeine is present in an amount of no more than 10 wt % based on the total weight of the atomizable formulation. In one aspect, caffeine is present in an amount of 0.01 to 10 wt % based on the total weight of the atomizable formulation. In one aspect, caffeine is present in an amount of 0.02 to 10 wt % based on the total weight of the atomizable formulation. In one aspect, caffeine is present in an amount of 0.05 to 10 wt % based on the total weight of the atomizable formulation. In one aspect, caffeine is present in an amount of 0.08 to 10 wt % based on the total weight of the atomizable formulation.

In one aspect, caffeine is present in an amount of no more than 5 wt % based on the total weight of the atomizable formulation. In one aspect, caffeine is present in an amount of 0.01 to 5 wt % based on the total weight of the atomizable formulation. In one aspect, caffeine is present in an amount of 0.02 to 5 wt % based on the total weight of the atomizable formulation. In one aspect, caffeine is present in an amount of 0.05 to 5 wt % based on the total weight of the atomizable formulation. In one aspect, caffeine is present in an amount of 0.08 to 5 wt % based on the total weight of the atomizable formulation.

In one aspect, caffeine is present in an amount of no more than 4 wt % based on the total weight of the atomizable formulation. In one aspect, caffeine is present in an amount of 0.01 to 4 wt % based on the total weight of the atomizable formulation. In one aspect, caffeine is present in an amount of 0.02 to 4 wt % based on the total weight of the atomizable formulation. In one aspect, caffeine is present in an amount of 0.05 to 4 wt % based on the total weight of the atomizable formulation. In one aspect, caffeine is present in an amount of 0.08 to 4 wt % based on the total weight of the atomizable formulation.

In one aspect, caffeine is present in an amount of no more than 3wt% based on the total weight of the atomizable formulation. In one aspect, caffeine is present in an amount of 0.01 to 3wt% based on the total weight of the atomizable formulation. In one aspect, caffeine is present in an amount of 0.02 to 3wt% based on the total weight of the atomizable formulation. In one aspect, caffeine is present in an amount of 0.05 to 3wt% based on the total weight of the atomizable formulation. In one aspect, caffeine is present in an amount of 0.08 to 3wt% based on the total weight of the atomizable formulation. In one aspect, caffeine is present in an amount of 0.1 to 3wt% based on the total weight of the atomizable formulation. In one aspect, caffeine is present in an amount of 0.2 to 3wt% based on the total weight of the atomizable formulation. In one aspect, caffeine is present in an amount of 0.5 to 3 wt % based on the total weight of the atomizable formulation. In one aspect, caffeine is present in an amount of 0.8 to 3 wt % based on the total weight of the atomizable formulation. In one aspect, caffeine is present in an amount of 1 to 3 wt % based on the total weight of the atomizable formulation. In one aspect, caffeine is present in an amount of 1.5 to 3 wt % based on the total weight of the atomizable formulation. In one aspect, caffeine is present in an amount of 2 to 3 wt % based on the total weight of the atomizable formulation.

In one aspect, caffeine is present in an amount of no more than 2 wt % based on the total weight of the atomizable formulation. In one aspect, caffeine is present in an amount of 0.01 to 2 wt % based on the total weight of the atomizable formulation. In one aspect, caffeine is present in an amount of 0.02 to 2 wt % based on the total weight of the atomizable formulation. In one aspect, caffeine is present in an amount of 0.05 to 2 wt % based on the total weight of the atomizable formulation. In one aspect, caffeine is present in an amount of 0.08 to 2 wt % based on the total weight of the atomizable formulation.

In one embodiment, caffeine is present in an amount of no more than 1 wt% based on the total weight of the atomizable formulation. In one embodiment, caffeine is present in an amount of 0.01 to 1 wt% based on the total weight of the atomizable formulation. In one embodiment, caffeine is present in an amount of 0.02 to 1 wt% based on the total weight of the atomizable formulation. In one embodiment, caffeine is present in an amount of 0.05 to 1 wt% based on the total weight of the atomizable formulation. In one embodiment, caffeine is present in an amount of 0.08 to 1 wt% based on the total weight of the atomizable formulation. In one embodiment, caffeine is present in an amount of 0.1 to 1 wt% based on the total weight of the atomizable formulation. Solvent

As discussed herein, the atomizable formulation comprises a solvent selected from a mixture of water, propylene glycol, glycerol, and the like. In one aspect, the solvent is at least water. In one aspect, the solvent is at least propylene glycol. In one aspect, the solvent is at least glycerol. In one aspect, the solvent is a mixture of at least propylene glycol and water. In one aspect, the solvent is a mixture of at least propylene glycol and glycerol. In one aspect, the solvent is a mixture of at least water, propylene glycol, and glycerol.

In one aspect, the solvent is selected from a mixture of at least propylene glycol and water, and the weight ratio of water to propylene glycol is 10:90 to 90:10. In one aspect, the weight ratio of water to propylene glycol is 15:85 to 85:15. In one aspect, the weight ratio of water to propylene glycol is 20:80 to 80:20. In one aspect, the weight ratio of water to propylene glycol is 25:75 to 75:25. In one aspect, the weight ratio of water to propylene glycol is 30:70 to 70:30. In one aspect, the weight ratio of water to propylene glycol is 35:65 to 65:35. In one aspect, the weight ratio of water to propylene glycol is 40:60 to 60:40. In one aspect, the weight ratio of water to propylene glycol is 45:55 to 55:45. In one embodiment, the weight ratio of water to propylene glycol is 50:50.

In one aspect, the solvent is selected from a mixture of at least propylene glycol and water, and the weight ratio of water to propylene glycol is 10:90 to 85:15. In one aspect, the weight ratio of water to propylene glycol is 10:90 to 80:20. In one aspect, the weight ratio of water to propylene glycol is 10:90 to 75:25. In one aspect, the weight ratio of water to propylene glycol is 10:90 to 70:30. In one aspect, the weight ratio of water to propylene glycol is 10:90 to 65:35. In one aspect, the weight ratio of water to propylene glycol is 10:90 to 60:40. In one aspect, the weight ratio of water to propylene glycol is 10:90 to 55:45. In one aspect, the weight ratio of water to propylene glycol is 10:90 to 50:50.

In one aspect, the solvent is selected from a mixture of at least propylene glycol and water, and the weight ratio of water to propylene glycol is 15:85 to 90:10. In one aspect, the weight ratio of water to propylene glycol is 20:80 to 90:10. In one aspect, the weight ratio of water to propylene glycol is 25:75 to 90:10. In one aspect, the weight ratio of water to propylene glycol is 30:70 to 90:10. In one aspect, the weight ratio of water to propylene glycol is 35:65 to 90:10. In one aspect, the weight ratio of water to propylene glycol is 40:60 to 90:10. In one aspect, the weight ratio of water to propylene glycol is 45:65 to 90:10. In one aspect, the weight ratio of water to propylene glycol is 50:50 to 90:10.

In one aspect, the solvent is selected from a mixture of at least glycerol and water, and the weight ratio of water to glycerol is 10:90 to 90:10. In one aspect, the weight ratio of water to glycerol is 15:85 to 85:15. In one aspect, the weight ratio of water to glycerol is 20:80 to 80:20. In one aspect, the weight ratio of water to glycerol is 25:75 to 75:25. In one aspect, the weight ratio of water to glycerol is 30:70 to 70:30. In one aspect, the weight ratio of water to glycerol is 35:65 to 65:35. In one aspect, the weight ratio of water to glycerol is 40:60 to 60:40. In one aspect, the weight ratio of water to glycerol is 45:55 to 55:45. In one aspect, the weight ratio of water to glycerol is 50:50.

In one aspect, the solvent is selected from a mixture of at least glycerol and water, and the weight ratio of water to glycerol is 10:90 to 85:15. In one aspect, the weight ratio of water to glycerol is 10:90 to 80:20. In one aspect, the weight ratio of water to glycerol is 10:90 to 75:25. In one aspect, the weight ratio of water to glycerol is 10:90 to 70:30. In one aspect, the weight ratio of water to glycerol is 10:90 to 65:35. In one aspect, the weight ratio of water to glycerol is 10:90 to 60:40. In one aspect, the weight ratio of water to glycerol is 10:90 to 55:45. In one aspect, the weight ratio of water to glycerol is 10:90 to 50:50.

In one aspect, the solvent is selected from a mixture of at least glycerol and water, and the weight ratio of water to glycerol is 15:85 to 90:10. In one aspect, the weight ratio of water to glycerol is 20:80 to 90:10. In one aspect, the weight ratio of water to glycerol is 25:75 to 90:10. In one aspect, the weight ratio of water to glycerol is 30:70 to 90:10. In one aspect, the weight ratio of water to glycerol is 35:65 to 90:10. In one aspect, the weight ratio of water to glycerol is 40:60 to 90:10. In one aspect, the weight ratio of water to glycerol is 45:65 to 90:10. In one aspect, the weight ratio of water to glycerol is 50:50 to 90:10.

In one aspect, the solvent is selected from a mixture of at least propylene glycol and glycerol, and the weight ratio of propylene glycol to glycerol is 10:90 to 90:10. In one aspect, the weight ratio of propylene glycol to glycerol is 15:85 to 85:15. In one aspect, the weight ratio of propylene glycol to glycerol is 20:80 to 80:20. In one aspect, the weight ratio of propylene glycol to glycerol is 25:75 to 75:25. In one aspect, the weight ratio of propylene glycol to glycerol is 30:70 to 70:30. In one aspect, the weight ratio of propylene glycol to glycerol is 35:65 to 65:35. In one aspect, the weight ratio of propylene glycol to glycerol is 40:60 to 60:40. In one aspect, the weight ratio of propylene glycol to glycerol is 45:55 to 55:45. In one embodiment, the weight ratio of propylene glycol to glycerol is 50:50.

In one aspect, the solvent is selected from a mixture of at least propylene glycol and glycerol, and the weight ratio of propylene glycol to glycerol is 10:90 to 85:15. In one aspect, the weight ratio of propylene glycol to glycerol is 10:90 to 80:20. In one aspect, the weight ratio of propylene glycol to glycerol is 10:90 to 75:25. In one aspect, the weight ratio of propylene glycol to glycerol is 10:90 to 70:30. In one aspect, the weight ratio of propylene glycol to glycerol is 10:90 to 65:35. In one aspect, the weight ratio of propylene glycol to glycerol is 10:90 to 60:40. In one aspect, the weight ratio of propylene glycol to glycerol is 10:90 to 55:45. In one aspect, the weight ratio of propylene glycol to glycerol is 10:90 to 50:50.

In one embodiment, the solvent is selected from a mixture of at least propylene glycol and glycerol, and the weight ratio of propylene glycol to glycerol is 15:85 to 90:10. In one embodiment, the weight ratio of propylene glycol to glycerol is 20:80 to 90:10. In one embodiment, the weight ratio of propylene glycol to glycerol is 25:75 to 90:10. In one embodiment, the weight ratio of propylene glycol to glycerol is 30:70 to 90:10. In one embodiment, the weight ratio of propylene glycol to glycerol is 35:65 to 90:10. In one embodiment, the weight ratio of propylene glycol to glycerol is 40:60 to 90:10. In one embodiment, the weight ratio of propylene glycol to glycerol is 45:65 to 90:10. In one embodiment, the weight ratio of propylene glycol to glycerol is 50:50 to 90:10. Water

In one aspect, the solvent of the atomizable formulation comprises water. Water can be present in any suitable amount. In one aspect, water is present in an amount of at least 5 wt.% based on the atomizable formulation. In one aspect, water is present in an amount of at least 10 wt.% based on the atomizable formulation. In one aspect, water is present in an amount of at least 15 wt.% based on the atomizable formulation. In one aspect, water is present in an amount of at least 20 wt.% based on the atomizable formulation. In one aspect, water is present in an amount of at least 25 wt.% based on the atomizable formulation. In one aspect, water is present in an amount of at least 30 wt.% based on the atomizable formulation. In one aspect, water is present in an amount of at least 35 wt.% based on the atomizable formulation.

In one aspect, water is present in an amount of no more than 70 wt.% based on the atomizable formulation. In one aspect, water is present in an amount of no more than 65 wt.% based on the atomizable formulation. In one aspect, water is present in an amount of no more than 60 wt.% based on the atomizable formulation. In one aspect, water is present in an amount of no more than 55 wt.% based on the atomizable formulation. In one aspect, water is present in an amount of no more than 50 wt.% based on the atomizable formulation. In one aspect, water is present in an amount of no more than 45 wt.% based on the atomizable formulation. In one aspect, water is present in an amount of no more than 40 wt.% based on the atomizable formulation.

In one embodiment, water is present in an amount of 5 to 60 wt.% based on the atomizable formulation. In one embodiment, water is present in an amount of 10 to 60 wt.% based on the atomizable formulation. In one embodiment, water is present in an amount of 15 to 60 wt.% based on the atomizable formulation. In one embodiment, water is present in an amount of 20 to 60 wt.% based on the atomizable formulation. In one embodiment, water is present in an amount of 25 to 60 wt.% based on the atomizable formulation. In one embodiment, water is present in an amount of 30 to 60 wt.% based on the atomizable formulation. In one embodiment, water is present in an amount of 35 to 60 wt.% based on the atomizable formulation.

In one aspect, water is present in an amount of 5 to 50 wt.% based on the atomizable formulation. In one aspect, water is present in an amount of 10 to 50 wt.% based on the atomizable formulation. In one aspect, water is present in an amount of 15 to 50 wt.% based on the atomizable formulation. In one aspect, water is present in an amount of 20 to 50 wt.% based on the atomizable formulation. In one aspect, water is present in an amount of 25 to 50 wt.% based on the atomizable formulation. In one aspect, water is present in an amount of 30 to 50 wt.% based on the atomizable formulation. In one aspect, water is present in an amount of 35 to 50 wt.% based on the atomizable formulation.

In one embodiment, water is present in an amount of 5 to 40 wt.% based on the atomizable formulation. In one embodiment, water is present in an amount of 10 to 40 wt.% based on the atomizable formulation. In one embodiment, water is present in an amount of 15 to 40 wt.% based on the atomizable formulation. In one embodiment, water is present in an amount of 20 to 40 wt.% based on the atomizable formulation. In one embodiment, water is present in an amount of 25 to 40 wt.% based on the atomizable formulation. In one embodiment, water is present in an amount of 30 to 40 wt.% based on the atomizable formulation. In one embodiment, water is present in an amount of 35 to 40 wt.% based on the atomizable formulation. Propylene glycol

In one aspect, the solvent of the atomizable formulation comprises propylene glycol. Propylene glycol can be present in any suitable amount. In one aspect, propylene glycol is present in an amount of at least 5wt.% based on the atomizable formulation. In one aspect, propylene glycol is present in an amount of at least 10wt.% based on the atomizable formulation. In one aspect, propylene glycol is present in an amount of at least 15wt.% based on the atomizable formulation. In one aspect, propylene glycol is present in an amount of at least 20wt.% based on the atomizable formulation. In one aspect, propylene glycol is present in an amount of at least 25wt.% based on the atomizable formulation. In one aspect, propylene glycol is present in an amount of at least 30wt.% based on the atomizable formulation. In one aspect, propylene glycol is present in an amount of at least 35 wt.% based on the atomizable formulation. In one aspect, propylene glycol is present in an amount of at least 40 wt.% based on the atomizable formulation.

In one aspect, propylene glycol is present in an amount of no more than 70 wt.% based on the atomizable formulation. In one aspect, propylene glycol is present in an amount of no more than 65 wt.% based on the atomizable formulation. In one aspect, propylene glycol is present in an amount of no more than 60 wt.% based on the atomizable formulation. In one aspect, propylene glycol is present in an amount of no more than 55 wt.% based on the atomizable formulation. In one aspect, propylene glycol is present in an amount of no more than 50 wt.% based on the atomizable formulation. In one aspect, propylene glycol is present in an amount of no more than 45 wt.% based on the atomizable formulation.

In one aspect, propylene glycol is present in an amount of 5 to 70 wt.% based on the atomizable formulation. In one aspect, propylene glycol is present in an amount of 10 to 70 wt.% based on the atomizable formulation. In one aspect, propylene glycol is present in an amount of 15 to 70 wt.% based on the atomizable formulation. In one aspect, propylene glycol is present in an amount of 20 to 70 wt.% based on the atomizable formulation. In one aspect, propylene glycol is present in an amount of 25 to 70 wt.% based on the atomizable formulation. In one aspect, propylene glycol is present in an amount of 30 to 70 wt.% based on the atomizable formulation. In one aspect, propylene glycol is present in an amount of 35 to 70 wt.% based on the atomizable formulation. In one aspect, propylene glycol is present in an amount of 40 to 70 wt. % based on the atomizable formulation.

In one aspect, propylene glycol is present in an amount of 5 to 60 wt.% based on the atomizable formulation. In one aspect, propylene glycol is present in an amount of 10 to 60 wt.% based on the atomizable formulation. In one aspect, propylene glycol is present in an amount of 15 to 60 wt.% based on the atomizable formulation. In one aspect, propylene glycol is present in an amount of 20 to 60 wt.% based on the atomizable formulation. In one aspect, propylene glycol is present in an amount of 25 to 60 wt.% based on the atomizable formulation. In one aspect, propylene glycol is present in an amount of 30 to 60 wt.% based on the atomizable formulation. In one aspect, propylene glycol is present in an amount of 35 to 60 wt.% based on the atomizable formulation. In one aspect, propylene glycol is present in an amount of 40 to 60 wt. % based on the atomizable formulation.

In one embodiment, propylene glycol is present in an amount of 5 to 50 wt.% based on the atomizable formulation. In one embodiment, propylene glycol is present in an amount of 10 to 50 wt.% based on the atomizable formulation. In one embodiment, propylene glycol is present in an amount of 15 to 50 wt.% based on the atomizable formulation. In one embodiment, propylene glycol is present in an amount of 20 to 50 wt.% based on the atomizable formulation. In one embodiment, propylene glycol is present in an amount of 25 to 50 wt.% based on the atomizable formulation. In one embodiment, propylene glycol is present in an amount of 30 to 50 wt.% based on the atomizable formulation. In one embodiment, propylene glycol is present in an amount of 35 to 50 wt.% based on the atomizable formulation. In one embodiment, propylene glycol is present in an amount of 40 to 50 wt. % based on the atomizable formulation. Glycerol

In one aspect, the solvent of the aerosolizable formulation comprises glycerol. Glycerol may be included in an aerosolizable formulation for a number of reasons. For example, many users desire to provide a visible aerosol "cloud" when the user exhales the formulation. The presence of glycerol in an aerosolizable formulation may allow for a more visible effect.

When present, glycerol can be present in any suitable amount. In one aspect, glycerol is present in an amount of at least 1 wt.% based on the atomizable formulation. In one aspect, glycerol is present in an amount of at least 2 wt.% based on the atomizable formulation. In one aspect, glycerol is present in an amount of at least 3 wt.% based on the atomizable formulation. In one aspect, glycerol is present in an amount of at least 4 wt.% based on the atomizable formulation. In one aspect, glycerol is present in an amount of at least 5 wt.% based on the atomizable formulation. In one aspect, glycerol is present in an amount of at least 10 wt.% based on the atomizable formulation. In one aspect, glycerol is present in an amount of at least 15 wt.% based on the atomizable formulation. In one aspect, glycerol is present in an amount of at least 20 wt.% based on the atomizable formulation.

In one aspect, glycerol is present in an amount of no more than 40 wt.% based on the atomizable formulation. In one aspect, glycerol is present in an amount of no more than 35 wt.% based on the atomizable formulation. In one aspect, glycerol is present in an amount of no more than 30 wt.% based on the atomizable formulation. In one aspect, glycerol is present in an amount of no more than 25 wt.% based on the atomizable formulation. In one aspect, glycerol is present in an amount of no more than 20 wt.% based on the atomizable formulation. In one aspect, glycerol is present in an amount of no more than 15 wt.% based on the atomizable formulation. In one aspect, glycerol is present in an amount of no more than 10 wt.% based on the atomizable formulation.

In one embodiment, glycerol is present in an amount of 1 to 60 wt.% based on the atomizable formulation. In one embodiment, glycerol is present in an amount of 2 to 60 wt.% based on the atomizable formulation. In one embodiment, glycerol is present in an amount of 5 to 60 wt.% based on the atomizable formulation. In one embodiment, glycerol is present in an amount of 10 to 60 wt.% based on the atomizable formulation.

In one embodiment, glycerol is present in an amount of 1 to 40 wt.% based on the atomizable formulation. In one embodiment, glycerol is present in an amount of 2 to 40 wt.% based on the atomizable formulation. In one embodiment, glycerol is present in an amount of 5 to 40 wt.% based on the atomizable formulation. In one embodiment, glycerol is present in an amount of 10 to 40 wt.% based on the atomizable formulation.

In one embodiment, glycerol is present in an amount of 1 to 20 wt.% based on the atomizable formulation. In one embodiment, glycerol is present in an amount of 2 to 20 wt.% based on the atomizable formulation. In one embodiment, glycerol is present in an amount of 5 to 20 wt.% based on the atomizable formulation. In one embodiment, glycerol is present in an amount of 10 to 20 wt.% based on the atomizable formulation.

Despite the desire for a visible aerosol "cloud", we have found that the presence of glycerol may be detrimental to the solubility of caffeine. Therefore, in some aspects, glycerol is present in a limited amount or not at all. In one aspect, based on the atomizable formulation, the atomizable formulation contains glycerol in an amount of no more than 10 wt.%. In one aspect, based on the atomizable formulation, the atomizable formulation contains glycerol in an amount of no more than 8 wt.%. In one aspect, based on the atomizable formulation, the atomizable formulation contains glycerol in an amount of no more than 5 wt.%. In one aspect, based on the atomizable formulation, the atomizable formulation contains glycerol in an amount of no more than 2 wt.%. In one aspect, based on the atomizable formulation, the atomizable formulation contains glycerol in an amount of no more than 1 wt.%. In one embodiment, the atomizable formulation contains glycerol in an amount of no more than 0.5 wt.% based on the atomizable formulation. In one embodiment, the atomizable formulation contains glycerol in an amount of no more than 0.2 wt.% based on the atomizable formulation. In one embodiment, the atomizable formulation contains glycerol in an amount of no more than 0.1 wt.% based on the atomizable formulation. In one embodiment, the atomizable formulation contains glycerol in an amount of no more than 0.01 wt.% based on the atomizable formulation. In one embodiment, the atomizable formulation does not contain glycerol. Buffer

As discussed herein, the sprayable formulation comprises a buffered solution containing benzoic acid and a benzoate salt.

In one aspect, the benzoate is at least sodium benzoate. In one aspect, the benzoate is at least potassium benzoate. In one aspect, the benzoate is a mixture of sodium benzoate and potassium benzoate.

In one embodiment, the weight ratio of benzoate to benzoic acid is 10:90 to 90:10. In one embodiment, the weight ratio of benzoate to benzoic acid is 15:85 to 85:15. In one embodiment, the weight ratio of benzoate to benzoic acid is 20:80 to 80:20. In one embodiment, the weight ratio of benzoate to benzoic acid is 25:75 to 75:25. In one embodiment, the weight ratio of benzoate to benzoic acid is 30:70 to 70:30. In one embodiment, the weight ratio of benzoate to benzoic acid is 35:65 to 65:35. In one embodiment, the weight ratio of benzoate to benzoic acid is 40:60 to 60:40. In one embodiment, the weight ratio of benzoate to benzoic acid is 45:55 to 55:45. In one embodiment, the weight ratio of benzoate to benzoic acid is 50:50.

In one embodiment, the weight ratio of benzoate to benzoic acid is from 10:90 to 85:15. In one embodiment, the weight ratio of benzoate to benzoic acid is from 10:90 to 80:20. In one embodiment, the weight ratio of benzoate to benzoic acid is from 10:90 to 75:25. In one embodiment, the weight ratio of benzoate to benzoic acid is from 10:90 to 70:30. In one embodiment, the weight ratio of benzoate to benzoic acid is from 10:90 to 65:35. In one embodiment, the weight ratio of benzoate to benzoic acid is from 10:90 to 60:40. In one embodiment, the weight ratio of benzoate to benzoic acid is from 10:90 to 55:45. In one embodiment, the weight ratio of benzoate to benzoic acid is 10:90 to 50:50.

In one embodiment, the weight ratio of benzoate to benzoic acid is 15:85 to 90:10. In one embodiment, the weight ratio of benzoate to benzoic acid is 20:80 to 90:10. In one embodiment, the weight ratio of benzoate to benzoic acid is 25:75 to 90:10. In one embodiment, the weight ratio of benzoate to benzoic acid is 30:70 to 90:10. In one embodiment, the weight ratio of benzoate to benzoic acid is 35:65 to 90:10. In one embodiment, the weight ratio of benzoate to benzoic acid is 40:60 to 90:10. In one embodiment, the weight ratio of benzoate to benzoic acid is 45:55 to 90:10. In one embodiment, the weight ratio of benzoate to benzoic acid is 50:50 to 90:10. Formulation

In one aspect, the atomizable formulation further comprises one or more flavoring or odorant components. As used herein, the terms "flavor" and "flavorant" refer to materials that can be used in products to create a desired taste or aroma for adult consumers, as permitted by local regulations. They can include extracts (e.g., licorice, hydrangea, white bark, magnolia leaves, chamomile, fenugreek, cloves, menthol, Japanese mint, aniseed, cinnamon, herbs, wintergreen, cherry, berry, peach, apple, Drambuie, bourbon, Scotch whisky, whiskey, spearmint, peppermint, lavender, cardamom, celery, cascarilla, nutmeg, sandalwood, bergamot, geranium, honey essence, rose oil, vanilla, lemon of lemon, orange, cinnamon, caraway, cognac, jasmine, ylang-ylang, sage, fennel, piment, ginger, anise, coriander, coffee, or peppermint oil from any species of the genus Menthus), flavor enhancers, bitter taste receptor site blockers, sensory receptor site activators or stimulants, sugars and/or sugar substitutes (e.g., sucralose, acesulfame potassium, aspartame, saccharin, cyclamates, lactose, sucrose, glucose, fructose, sorbitol, or mannitol), and other additives such as charcoal, chlorophyll, minerals, botanicals, or breath fresheners. They may be imitation, synthetic or natural ingredients or blends thereof. They may be in any suitable form, for example oil, liquid or powder. The one or more flavors may be selected from the group consisting of (4-(p-)methoxyphenyl)-2-butanone, vanillin, γ-undecalactone, menthone, 5-propenyl guaethol, menthol, p-menthyl-8-thiol-3-one and mixtures thereof. In one aspect, the flavor is at least menthol.

If present, the one or more spices may be present in any suitable amount. In one aspect, the one or more spices are present in a total amount of no more than 10 wt.% based on the atomizable formulation. In one aspect, the one or more spices are present in a total amount of no more than 7 wt.% based on the atomizable formulation. In one aspect, the one or more spices are present in a total amount of no more than 5 wt.% based on the atomizable formulation. In one aspect, the one or more spices are present in a total amount of no more than 4 wt.% based on the atomizable formulation. In one aspect, the one or more spices are present in a total amount of no more than 3 wt.% based on the atomizable formulation. In one aspect, the one or more spices are present in a total amount of no more than 2 wt.% based on the atomizable formulation. In one aspect, the one or more fragrances are present in a total amount of no more than 1 wt. % based on the atomizable formulation.

In one aspect, the one or more spices are present in a total amount of 0.01 to 5 wt.% based on the atomizable formulation. In one aspect, the one or more spices are present in a total amount of 0.01 to 4 wt.% based on the atomizable formulation. In one aspect, the one or more spices are present in a total amount of 0.01 to 3 wt.% based on the atomizable formulation. In one aspect, the one or more spices are present in a total amount of 0.01 to 2 wt.% based on the atomizable formulation. In one aspect, the one or more spices are present in a total amount of 0.01 to 1 wt.% based on the atomizable formulation. In one aspect, the one or more spices are present in a total amount of 0.01 to 0.5 wt.% based on the atomizable formulation.

In one aspect, the atomizable formulation further comprises one or more solubilizers. As used herein, the term "solubilizer" refers to a substance that increases the solubility of caffeine in the formulation. In one aspect, the one or more solubilizers are selected from the group consisting of benzyl alcohol, triacetin, and mixtures thereof. In one aspect, the one or more solubilizers are at least benzyl alcohol.

In one embodiment, the atomizable formulation is in liquid form. In one embodiment, the atomizable formulation is not in liquid form. In one embodiment, the atomizable formulation is in the form of a gel or paste. Apparatus and Methods

As discussed herein, in one aspect, a method for forming an aerosol is provided, the method comprising atomizing an aerosolizable formulation comprising (i) caffeine; (ii) a solvent selected from the group consisting of water, propylene glycol, glycerin, and mixtures thereof; and (iii) a buffer comprising benzoic acid and a benzoate salt.

The formulation may be incorporated or delivered by any means. In one aspect, the present invention provides an incorporable aerosol formulation comprising (a) one or more containers; and (b) an aerosol formulation as defined herein. The container may be any suitable container, for example one that allows for storage or delivery of the formulation. In one aspect, the container is configured to be coupled to an electronic aerosol supply system. The container may be configured to be in fluid communication with the electronic aerosol supply system so that the formulation may be delivered to the electronic aerosol supply system. As described above, the present disclosure relates to containers that can be used in electronic aerosol supply systems (such as electronic cigarettes). Throughout the following description, the term "electronic cigarette" is used; however, this term is used interchangeably with electronic aerosol delivery system.

As discussed herein, the container of the present invention is typically provided for delivering an aerosolizable formulation to or within an electronic cigarette. The aerosolizable formulation may be loaded into an electronic cigarette or may be sold as a separate container for subsequent use with or in an electronic cigarette. As understood by those skilled in the art, an electronic cigarette may contain a unit known as a detachable aerosolizing cartridge, which typically includes a storage tank for the aerosolizable formulation and an aerosolizer (such as a wick material and a heating element for vaporizing the aerosolizable formulation). In some electronic cigarettes, the aerosolizing cartridge is part of a one-piece device and is not detachable. In one aspect, the container is an atomized cigarette cartridge or a part of an atomized cigarette cartridge. In one aspect, the container is not an atomized cigarette cartridge or a part of an atomized cigarette cartridge, but a container, such as a can, which can be used to deliver nicotine formulation to or in an electronic cigarette.

In one aspect, the container is part of an electronic cigarette. Therefore, in a further aspect, the present invention provides an electronic aerosol delivery system comprising: an aerosolizable formulation as defined herein; an aerosolizer for aerosolizing the formulation for inhalation by a user of the electronic aerosol delivery system; and a power supply comprising a battery or battery pack for powering the aerosolizer.

In one aspect, the present invention provides an electronic aerosol delivery system comprising: (a) an aerosolizer for aerosolizing a formulation for inhalation by a user of the electronic aerosol delivery system; (b) a power supply comprising a battery or battery pack for powering the aerosolizer; and (c) an aerosolizable formulation comprising caffeine; wherein the aerosol delivery system provides at least 0.5 mg of caffeine per gram of aerosol. We have found that the present system allows for the delivery of exceptionally high amounts of caffeine per gram of aerosol. This is due, at least in part, to the high solubility of caffeine in the aerosolizable formulation.

In one aspect, the aerosol supply system provides at least 1 mg of caffeine per gram of aerosol. In one aspect, the aerosol supply system provides at least 2 mg of caffeine per gram of aerosol. In one aspect, the aerosol supply system provides at least 5 mg of caffeine per gram of aerosol. In one aspect, the aerosol supply system provides at least 10 mg of caffeine per gram of aerosol. In one aspect, the aerosol supply system provides at least 15 mg of caffeine per gram of aerosol. In one aspect, the aerosol supply system provides at least 20 mg of caffeine per gram of aerosol. In one aspect, the aerosol supply system provides at least 25 mg of caffeine per gram of aerosol. In one aspect, the aerosol supply system provides at least 30 mg of caffeine per gram of aerosol. In one aspect, the aerosol supply system provides at least 40 mg of caffeine per gram of aerosol.

In one aspect, the aerosol supply system provides 0.5 to 100 mg of caffeine per gram of aerosol. In one aspect, the aerosol supply system provides 0.5 to 90 mg of caffeine per gram of aerosol. In one aspect, the aerosol supply system provides 0.5 to 80 mg of caffeine per gram of aerosol. In one aspect, the aerosol supply system provides 0.5 to 70 mg of caffeine per gram of aerosol. In one aspect, the aerosol supply system provides 0.5 to 60 mg of caffeine per gram of aerosol. In one aspect, the aerosol supply system provides 0.5 to 50 mg of caffeine per gram of aerosol. In one aspect, the aerosol supply system provides 1 to 50 mg of caffeine per gram of aerosol. In one aspect, the aerosol supply system provides 2 to 50 mg of caffeine per gram of aerosol. In one aspect, the aerosol supply system provides 5 to 50 mg of caffeine per gram of aerosol. In one aspect, the aerosol supply system provides 10 to 50 mg of caffeine per gram of aerosol. In one aspect, the aerosol supply system provides 15 to 50 mg of caffeine per gram of aerosol. In one aspect, the aerosol supply system provides 20 to 50 mg of caffeine per gram of aerosol. In one aspect, the aerosol supply system provides 25 to 50 mg of caffeine per gram of aerosol. In one aspect, the aerosol supply system provides 30 to 50 mg of caffeine per gram of aerosol. In one aspect, the aerosol delivery system provides 30 to 40 mg of caffeine per gram of aerosol.

In addition to the aerosolizable formulation of the present invention and the system containing the same (such as a container and an electronic aerosol supply system), the present invention provides a method for improving the solubility of caffeine in an aerosolizable formulation, the method comprising the following steps: (a) providing an aerosolizable material comprising a solvent selected from water, propylene glycol, glycerin and mixtures thereof; (b) combining caffeine and a buffer solution comprising benzoic acid and a benzoate salt into the aerosolizable material to provide an aerosolizable formulation.

In a further aspect, an article comprising an aerosolizable formulation as defined herein is provided. The article may be a container, such as a bottle, or may be an assembly for use with an aerosol supply device. For example, the article may comprise an area (reservoir) for receiving an aerosolizable formulation as defined herein, an aerosol generating assembly, an aerosol generating area and/or a mouthpiece.

In some embodiments, an article of manufacture is provided for use with an aerosol delivery system, the article comprising a reservoir containing an aerosolizable formulation as defined herein, an aerosol generating component (such as a heater), an aerosol generating region, a transmission element, and a mouthpiece.

The aerosolizable formulation can be transferred from a reservoir for receiving the aerosolizable formulation to the aerosol generating assembly via a transfer element such as a wick, a pump or the like. A person skilled in the art will be able to select a suitable transfer element depending on the type of aerosolizable formulation to be transferred and the rate at which it must be supplied. Transfer elements such as wicks formed of fiber materials, foamed materials, sintered materials, woven fabrics and non-woven fabric materials are particularly worth mentioning.

The air flow path typically extends through the article (optionally via the device) to an outlet. The path is oriented so that the generated aerosol is entrained in the air flow so that it can be delivered to the outlet for inhalation by the user.

In one embodiment, the aerosol generating component is a heater.

In one embodiment, the aerosol generating assembly applies ultrasonic energy to the aerosolizable formulation. The aerosol may be formed at a temperature below 60°C. The aerosol may be formed at a temperature below 50°C. The aerosol may be formed at a temperature below 40°C. The aerosol may be formed at a temperature below 30°C. The aerosol may be formed at a temperature below 25°C.

Typically, the area for receiving the aerosolizable formulation will allow the article to be refilled with the aerosolizable formulation as it is consumed during use.

FIG1 is a highly schematic diagram (not to scale) of an example aerosol delivery system (such as an electronic cigarette 10) to which the embodiments may be applied. The electronic cigarette has a generally cylindrical shape extending along a longitudinal axis indicated by a dashed line (although aspects of the present invention are applicable to electronic cigarettes configured in other shapes and arrangements), and includes two main components, namely, an aerosol delivery device 20 and a product 30.

Article 30 includes a reservoir 38 for an aerosolizable formulation (source liquid) containing the aerosolizable formulation (source liquid) from which an aerosol is to be generated. Article 30 further includes an aerosol generating assembly (heating element or heater) 36 for heating the aerosolizable formulation to generate the aerosol. A transfer element or wicking element or wick 37 is provided to deliver the aerosolizable formulation from the reservoir 38 to the heating element 36. One or more portions of the wick 37 are in fluid communication with the aerosolizable formulation in the reservoir 38, and by wicking or capillary action, the aerosolizable formulation is drawn along or through the wick 37 to one or more portions of the wick 37 in contact with the heater 36.

By providing heat energy to the aerosolizable formulation to cause evaporation, vaporization of the aerosolizable formulation occurs at the interface between the wick 37 and the heater 36, thereby generating an aerosol. The aerosolizable formulation, the wick 37, and the heater 36 may be collectively referred to as an aerosol or vapor source. The wick 37 and the heater 36 may be collectively referred to as a vaporizer or atomizer 15.

The article 30 further includes a mouthpiece 35 having an opening through which a user can inhale the aerosol generated by the vaporizer 15. The aerosol for inhalation can be described as an aerosol stream or an inhalable air stream.

The aerosol delivery device 20 includes a power source (rechargeable battery or battery pack 14, hereinafter referred to as a battery pack) for providing power to the electronic cigarette 10 and a controller (printed circuit board (PCB)) 28 and/or other electronic devices for overall control of the electronic cigarette 10. The aerosol delivery device can therefore also be regarded as a battery pack area, or a control unit or control area.

For example, in use, as controlled by the circuit board 28, possibly in response to pressure changes detected by an air pressure sensor (not shown), when the heater 36 receives power from the battery pack 14, the heater 36 vaporizes the aerosol formulation delivered by the wick 37 to generate an aerosol, and this aerosol stream is then inhaled by the user through the opening of the mouthpiece 35. When the user inhales on the mouthpiece, the aerosol is carried from the aerosol source to the mouthpiece 35 along the air channel (not shown in FIG. 1 ) connecting the aerosol source and the mouthpiece opening.

In a further aspect, an aerosol delivery system is provided, comprising an aerosol delivery device as defined herein and an article.

In this regard, the method may be further defined according to any of the above characteristics.

In a further aspect, a method for generating an aerosol is provided, comprising generating an aerosol from an aerosolizable formulation as defined herein.

The methods of the present invention may include additional steps before the listed steps, after the listed steps, or between one or more of the listed steps.

The present invention will now be described with reference to the following non-limiting examples. Examples

All percentages given in the examples are by weight.

A preliminary analysis was performed on atomizable formulations containing caffeine and various solvents including water, propylene glycol (PG), propylene glycol and water, and glycerin, water and propylene glycol. The solubility of caffeine in the formulations was determined. The same analysis was then performed on the same formulations but further containing benzoic acid/sodium benzoate buffer (0.5 Meq/0.5 Meq). Table 1 provides the results of the analysis. Table 1 Preparation %glycerin %PG %water Measured concentration (mg/g) – without buffer Measured concentration (mg/g) – with buffer 1.1 0 100 0 11.954 11.74 1.2 0 60 40 27.79 76.91 1.3 0 50 50 31.15 68.68 1.4 0 40 60 25.96 80.29 1.5 0 0 100 19.74 44.56 1.6 10 50 40 33.558 61.89 1.7 10 40 50 26.68 66.82 1.8 20 60 20 16.67 37.49 1.9 40 60 0 8.69 12.92 1.10 50 40 10 13.47 14.32

The presence of benzoic acid/sodium benzoate buffer was found to improve the overall solubility of caffeine in the solvent of the atomizable formulation.

Various modifications and variations of the present invention will be apparent to those skilled in the art without departing from the scope and spirit of the present invention. Although the present invention has been described in conjunction with specific preferred embodiments, it should be understood that the claimed invention should not be unduly limited to such specific embodiments. In fact, various modifications of the described modes for carrying out the present invention that are apparent to those skilled in chemistry or related fields are intended to fall within the scope of the invention set forth below in the claims.

This disclosure will now be further defined in the following items:

1. An atomizable formulation comprising (i) caffeine; (ii) a solvent selected from water, propylene glycol, glycerin and mixtures thereof; and (iii) a buffer solution comprising benzoic acid and a benzoate salt.

2. The atomizable formulation according to item 1, wherein caffeine is present in an amount of at least 1 wt. % based on the atomizable formulation.

3. The atomizable formulation according to item 1 or 2, wherein caffeine is present in an amount of at least 2 wt.%, based on the atomizable formulation.

4. The atomizable formulation according to item 1, 2 or 3, wherein caffeine is present in an amount of at least 4 wt.%, based on the atomizable formulation.

5. The atomizable formulation according to any one of items 1 to 4, wherein caffeine is present in an amount of not more than 10 wt.%, based on the atomizable formulation.

6. The atomizable formulation of any one of items 1 to 5, wherein the solvent is selected from (a) at least water, (b) at least propylene glycol, (c) at least glycerol, (d) a mixture of at least propylene glycol and water, (e) a mixture of at least glycerol and water, (f) a mixture of at least propylene glycol and glycerol, and (g) a mixture of at least water, propylene glycol and glycerol.

7. The atomizable formulation of any one of items 1 to 6, wherein the solvent is selected from (a) at least water, (b) at least propylene glycol, (c) a mixture of at least propylene glycol and water, (d) a mixture of at least propylene glycol and glycerol, and (e) a mixture of at least water, propylene glycol and glycerol.

8. The atomizable formulation of any one of items 1 to 7, wherein the solvent is selected from (a) at least water, (b) a mixture of at least propylene glycol and water, (c) a mixture of at least propylene glycol and glycerol, and (d) a mixture of at least water, propylene glycol and glycerol.

9. The atomizable formulation according to any one of items 1 to 8, wherein the solvent is selected from a mixture of at least propylene glycol and water.

10. The atomizable formulation according to item 9, wherein the weight ratio of water to propylene glycol is 20:80 to 80:20.

11. The atomizable formulation according to item 9, wherein the weight ratio of water to propylene glycol is 30:70 to 70:30.

12. The atomizable formulation according to item 9, wherein the weight ratio of water to propylene glycol is 30:70 to 60:40.

13. The atomizable formulation according to any one of items 1 to 12, wherein water is present in an amount of 10 to 60 wt.%, based on the atomizable formulation.

14. The atomizable formulation according to any one of items 1 to 13, wherein water is present in an amount of 20 to 60 wt.%, based on the atomizable formulation.

15. The atomizable formulation according to any one of items 1 to 14, wherein water is present in an amount of 30 to 50 wt.%, based on the atomizable formulation.

16. The atomizable formulation according to any one of items 1 to 15, wherein glycerol is present in an amount of 10 to 60 wt.%, based on the atomizable formulation.

17. The atomizable formulation according to any one of items 1 to 16, wherein glycerol is present in an amount of 10 to 40 wt.%, based on the atomizable formulation.

18. The atomizable formulation according to any one of items 1 to 17, wherein glycerol is present in an amount of not more than 20 wt.%, based on the atomizable formulation.

19. The atomizable formulation according to any one of items 1 to 18, wherein glycerol is present in an amount of not more than 10 wt.%, based on the atomizable formulation.

20. The atomizable formulation according to any one of items 1 to 19, wherein propylene glycol is present in an amount of at least 10 wt.%, based on the atomizable formulation.

21. The atomizable formulation according to any one of items 1 to 20, wherein propylene glycol is present in an amount of 10 to 60 wt.%, based on the atomizable formulation.

22. The atomizable formulation according to any one of items 1 to 21, wherein propylene glycol is present in an amount of 20 to 50 wt.%, based on the atomizable formulation.

23. The atomizable formulation according to any one of items 1 to 22, wherein the benzoate is selected from sodium benzoate, potassium benzoate and mixtures thereof.

24. The atomizable formulation of any one of items 1 to 23, wherein the benzoate is at least sodium benzoate.

25. The atomizable formulation according to any one of items 1 to 24, wherein the weight ratio of benzoate to benzoic acid is 20:80 to 80:20.

26. The atomizable formulation according to any one of items 1 to 25, wherein the weight ratio of benzoate to benzoic acid is 30:70 to 70:30.

27. The atomizable formulation according to any one of items 1 to 26, wherein the weight ratio of benzoate to benzoic acid is 40:60 to 60:40.

28. A method for forming an aerosol, the method comprising atomizing an aerosolizable formulation comprising (i) caffeine; (ii) a solvent selected from water, propylene glycol, glycerin, and mixtures thereof; and (iii) a buffer solution comprising benzoic acid and a benzoate salt.

29. The method according to item 28, wherein the atomizable formulation is an atomizable formulation as defined in any one of items 2 to 27.

30. An in-line atomizable formulation comprising (a) a container; and (b) an atomizable formulation comprising (i) caffeine; (ii) a solvent selected from water, propylene glycol, glycerin, and mixtures thereof; and (iii) a buffer solution comprising benzoic acid and a benzoate salt.

31. The inclusion atomizable formulation of item 30, wherein the atomizable formulation is an atomizable formulation as defined in any one of items 2 to 27.

32. The in-line aerosol formulation of item 30 or 31, wherein the container is configured to couple with an electronic aerosol supply system.

33. An electronic aerosol delivery system comprising: (a) an aerosol dispenser for aerosolizing a formulation for inhalation by a user of the electronic aerosol delivery system; (b) a power supply comprising a battery or battery pack for powering the aerosol dispenser; and (c) an aerosolizable formulation comprising (i) caffeine; (ii) a solvent selected from water, propylene glycol, glycerin, and mixtures thereof; and (iii) a buffer solution comprising benzoic acid and a benzoate salt.

34. The electronic aerosol supply system of item 33, wherein the aerosolizable formulation is an aerosolizable formulation as defined in any one of items 2 to 27.

35. A method for improving the solubility of caffeine in an atomizable formulation, the method comprising the following steps: (a) providing an atomizable material comprising a solvent selected from water, propylene glycol, glycerin and mixtures thereof; (b) adding caffeine and a buffer solution comprising benzoic acid and a benzoate salt into the atomizable material to provide the atomizable formulation.

36. The method according to item 35, wherein the atomizable formulation is an atomizable formulation as defined in any one of items 2 to 27.

10: Electronic cigarette 14: Battery pack 15: Vaporizer/atomizer 20: Aerosol supply device 28: Controller/circuit board 30: Product 35: Mouthpiece 36: Aerosol generating assembly/heating element/heater 37: Transmission element/wick element/wick 38: Storage device

The invention will now be described in detail by way of example only with reference to the accompanying drawings, in which: - Figure 1 is a highly schematic diagram (not to scale) of an example aerosol supply system; and Figure 2 shows the cubic model of caffeine solubility in propylene glycol, glycerol and water in the presence of benzoic acid/sodium benzoate buffer (0.5 Meq/0.5 Meq).

(without)

Claims (25)

A sprayable formulation comprising (i) caffeine; (ii) a solvent selected from water, propylene glycol, glycerin and mixtures thereof; and (iii) a buffer solution comprising benzoic acid and a benzoate salt. The atomizable formulation of claim 1, wherein caffeine is present in an amount of at least 1 wt.% based on the atomizable formulation, such as wherein caffeine is present in an amount of at least 2 wt.% based on the atomizable formulation, such as wherein caffeine is present in an amount of at least 4 wt.% based on the atomizable formulation. The atomizable formulation of any one of claims 1 to 2, wherein caffeine is present in an amount of not more than 10 wt.% based on the atomizable formulation. The atomizable formulation of any one of claims 1 to 3, wherein the solvent is selected from (a) at least water, (b) at least propylene glycol, (c) at least glycerol, (d) a mixture of at least propylene glycol and water, (e) a mixture of at least glycerol and water, (f) a mixture of at least propylene glycol and glycerol, and (g) a mixture of at least water, propylene glycol and glycerol. The atomizable formulation of any one of claims 1 to 4, wherein the solvent is selected from (a) at least water, (b) at least propylene glycol, (c) at least a mixture of propylene glycol and water, (d) at least a mixture of propylene glycol and glycerol, and (e) at least a mixture of water, propylene glycol and glycerol. The atomizable formulation of any one of claims 1 to 5, wherein the solvent is selected from (a) at least water, (b) a mixture of at least propylene glycol and water, (c) a mixture of at least propylene glycol and glycerol, and (d) a mixture of at least water, propylene glycol and glycerol. The atomizable formulation of any one of claims 1 to 6, wherein the solvent is selected from a mixture of at least propylene glycol and water. The atomizable formulation of claim 7, wherein the weight ratio of water to propylene glycol is 20:80 to 80:20, such as wherein the weight ratio of water to propylene glycol is 30:70 to 70:30. The atomizable formulation of claim 7 or 8, wherein the weight ratio of water to propylene glycol is 30:70 to 60:40. The atomizable formulation of any one of claims 1 to 9, wherein water is present in an amount of 10 to 60 wt.% based on the atomizable formulation, such as wherein water is present in an amount of 20 to 60 wt.% based on the atomizable formulation, such as wherein water is present in an amount of 30 to 50 wt.% based on the atomizable formulation. The atomizable formulation of any one of claims 1 to 10, wherein glycerol is present in an amount of 10 to 60 wt.% based on the atomizable formulation, such as wherein glycerol is present in an amount of 10 to 40 wt.% based on the atomizable formulation. A sprayable formulation according to any one of claims 1 to 11, wherein glycerol is present in an amount of not more than 20 wt.% based on the sprayable formulation, such as wherein glycerol is present in an amount of not more than 10 wt.% based on the sprayable formulation. The atomizable formulation of any one of claims 1 to 12, wherein propylene glycol is present in an amount of at least 10 wt.% based on the atomizable formulation. The atomizable formulation of any one of claims 1 to 13, wherein propylene glycol is present in an amount of 10 to 60 wt.% based on the atomizable formulation, such as wherein propylene glycol is present in an amount of 20 to 50 wt.% based on the atomizable formulation. A sprayable formulation according to any one of claims 1 to 14, wherein the benzoate is selected from sodium benzoate, potassium benzoate and mixtures thereof, such as wherein the benzoate is at least sodium benzoate. The atomizable formulation of any one of claims 1 to 15, wherein the weight ratio of benzoate to benzoic acid is 20:80 to 80:20, such as wherein the weight ratio of benzoate to benzoic acid is 30:70 to 70:30, such as wherein the weight ratio of benzoate to benzoic acid is 40:60 to 60:40. A method for forming an aerosol, the method comprising atomizing an atomizable formulation comprising (i) caffeine; (ii) a solvent selected from water, propylene glycol, glycerin, and mixtures thereof; and (iii) a buffer solution comprising benzoic acid and a benzoate salt. The method of claim 17, wherein the atomizable formulation is an atomizable formulation as defined in any one of claims 2 to 16. A drop-in aerosolizable formulation comprising (a) a container; and (b) an aerosolizable formulation comprising (i) caffeine; (ii) a solvent selected from water, propylene glycol, glycerin, and mixtures thereof; and (iii) a buffer solution comprising benzoic acid and a benzoate salt. The incorporation atomizable formulation of claim 19, wherein the atomizable formulation is an atomizable formulation as defined in any one of claims 2 to 16. The incorporable aerosol formulation of claim 19 or 20, wherein the container is configured to interface with an electronic aerosol supply system. An electronic aerosol delivery system comprising: (a) an aerosol dispenser for aerosolizing a formulation for inhalation by a user of the electronic aerosol delivery system; (b) a power supply comprising a battery or battery pack for powering the aerosol dispenser; and (c) an aerosolizable formulation comprising (i) caffeine; (ii) a solvent selected from water, propylene glycol, glycerin, and mixtures thereof; and (iii) a buffer solution comprising benzoic acid and a benzoate salt. An electronic aerosol supply system as claimed in claim 22, wherein the aerosolizable formulation is an aerosolizable formulation as defined in any one of claims 2 to 16. A method for improving the solubility of caffeine in an atomizable formulation, the method comprising the following steps: (a) providing an atomizable material comprising a solvent selected from water, propylene glycol, glycerin and mixtures thereof; (b) adding caffeine and a buffer solution comprising benzoic acid and a benzoate salt into the atomizable material to provide the atomizable formulation. The method of claim 24, wherein the atomizable formulation is an atomizable formulation as defined in any one of claims 2 to 16.