TW202412631A - Gel for particle dispersion, particle dispersion gel, method for producing gel for particle dispersion and method for producing particle dispersion gel - Google Patents

Abstract

The particle dispersion gel of the present invention comprises a polymer (A) and a solvent (B) and can disperse particles inside. The particle dispersion gel forms a three-dimensional network structure by the polymer (A), and the network structure contains the solvent (B), and the solvent (B) comprises a polyol compound (B1).

Description

Gel for particle dispersion, particle dispersion gel, method for producing particle dispersion gel, and method for producing particle dispersion gel

The present invention relates to a particle dispersion gel, a particle dispersion gel, a method for producing the particle dispersion gel, and a method for producing the particle dispersion gel.

A gel having a three-dimensional network structure can contain various particles inside. As a technology related to such a gel for dispersing particles, for example, the one described in Patent Document 1 (Japanese Patent Laid-Open No. 2018-115140) can be cited.

Patent document 1 describes an antibacterial and deodorizing hydrogel, which is characterized in that: it is a hydrogel containing fine powder of a calcium compound with calcium hydroxide as the main component, and the dispersed substance constituting the hydrogel is constructed into a three-dimensional network structure by physical crosslinking, and the fine powder of the calcium compound with calcium hydroxide as the main component is contained in the dispersion medium of the gel enclosed in the three-dimensional network structure, and the content of the fine powder of the calcium compound with calcium hydroxide as the main component is 5 to 300 parts by weight relative to 100 parts by weight of the hydrophilic polymer resin constituting the hydrogel. Prior art document   Patent document

Patent document 1: Japanese Patent Publication No. 2018-115140

[The problem the invention is trying to solve]

In order to improve the balance between the dispersibility and retention of the contained particles, a particle dispersing gel that can control the mesh size according to the size of the contained particles is sought. The present invention is completed in view of the above situation, and provides a particle dispersing gel that can easily control the mesh size, a particle dispersing gel using the same, and a method for manufacturing a particle dispersing gel that can easily control the mesh size, and a method for manufacturing a particle dispersing gel that can improve the dispersibility of particles. [Technical means for solving the problem]

The inventors of the present invention have conducted intensive research to achieve the above-mentioned problem. As a result, they have found that the mesh size can be easily controlled by including a polyol compound (B1) as the solvent (B) in a particle dispersion gel containing a polymer (A) and a solvent (B), thereby completing the present invention.

According to the present invention, there are provided a particle dispersion gel, a particle dispersion gel, a method for producing a particle dispersion gel, and a method for producing a particle dispersion gel as shown below.

[1] A particle dispersing gel comprising a polymer (A) and a solvent (B) and capable of dispersing particles therein, wherein the particle dispersing gel forms a three-dimensional network structure with the polymer (A), and the network structure contains the solvent (B), and the solvent (B) comprises a polyol compound (B1). [2] The particle dispersing gel as described in [1] above, wherein the molecular weight of the polyol compound (B1) is 50 to 300. [3] The particle dispersing gel as described in [1] or [2] above, wherein the viscosity of the solvent (B) measured at 25°C and 30 rpm using a B-type viscometer is 1 to 200 mPa·s. [4] The particle dispersion gel as described in any one of [1] to [3] above, wherein the boiling point of the solvent (B) is 180°C to 300°C. [5] The particle dispersion gel as described in any one of [1] to [4] above, wherein the polyol compound (B1) comprises a diol compound (B2) having a carbon number of 2 to 6. [6] The particle dispersion gel as described in any one of [1] to [5] above, wherein the polyol compound (B1) comprises one or more selected from the group consisting of ethylene glycol, 1,3-propylene glycol, 1,4-butylene glycol, 1,5-pentanediol and 1,6-hexanediol. [7] The particle dispersion gel as described in any one of the above [1] to [6], wherein the viscosity of the particle dispersion gel measured by a cone viscometer at 25°C, cone 2°/20 mm, and shear rate 15 s ^-1 is 10 mPa･s or more and 60000 mPa･s or less. [8] The particle dispersion gel as described in any one of the above [1] to [7], wherein the mode particle size of the stereo network structure measured by the photon correlation method in accordance with JIS Z 8826:2019 is X ₁ (nm), and the median particle size of the stereo network structure measured by the photon correlation method in accordance with JIS Z 8826:2019 is (X ₂ ) (nm), and X ₁ /X ₂ is 0.20 or more and 2.0 or less. [9] The particle dispersion gel as described in any one of [1] to [8] above, wherein the mode particle size (X ₁ ) of the stereo network structure measured by the photon correlation method according to JIS Z 8826:2019 is 10 nm or more. [10] The particle dispersion gel as described in any one of [1] to [9] above, wherein the median particle size (X ₂ ) of the stereo network structure measured by the photon correlation method according to JIS Z 8826:2019 is 50 nm or more. [11] The particle dispersion gel as described in any one of [1] to [10] above, wherein the polymer (A) comprises one or more selected from the group consisting of polysaccharides, proteins, peptides, (meth)acrylic acid polymers, polyvinyl alcohol polymers and polyvinyl pyrrolidone. [12] A particle dispersion gel as described in any one of [1] to [11] above, wherein the content of the polymer (A) in the particle dispersion gel is 0.01 mass % to 20.0 mass %. [13] A particle dispersion gel comprising the particle dispersion gel as described in any one of [1] to [12] above, and particles (C) dispersed in the particle dispersion gel. [14] A particle dispersion gel as described in [13] above, wherein the particles (C) comprise one or more selected from the group consisting of drugs, fragrances, antibacterial agents, fungicides, cells, metal particles, inorganic particles, polymer particles, catalysts, antiviral agents and antifungal agents. [15] The particle dispersion gel as described in [13] or [14] above, wherein the median particle size _D50 of the particles (C) measured by laser diffraction scattering is 0.01 μm or more and 10 μm or less. [16] A method for producing a particle dispersion gel, which is used to produce the particle dispersion gel as described in any one of [1] to [12] above, and comprises the following steps: obtaining a gel by mixing the polymer (A) and the solvent (B); and obtaining a particle dispersion gel having a three-dimensional network structure by kneading the gel. [17] A method for producing a particle dispersion gel as described in [16] above, wherein in the step of kneading the gel, the gel is kneaded using a roller mill. [18] A method for producing a particle dispersion gel, which is used to produce the particle dispersion gel as described in any one of [13] to [15] above, and comprises the following steps: obtaining a gel by mixing the polymer (A), the solvent (B) and the particles (C); and obtaining a particle dispersion gel having a three-dimensional network structure by kneading the gel. [19] A method for producing a particle dispersion gel as described in [18] above, wherein the particle dispersion gel forms a three-dimensional network structure by the polymer (A), and the solvent (B) is contained in the network structure, and the particles (C) are enclosed in the network structure. [20] A method for producing a particle dispersion gel as described in [18] or [19] above, wherein in the step of kneading the gel-like material, a roller mill is used to knead the gel-like material. [21] A method for producing a particle dispersion gel as described in any one of [18] to [20] above, wherein the content of the polymer (A) in the particle dispersion gel is not less than 0.01 mass % and not more than 20.0 mass %. [Effect of the Invention]

According to the present invention, a particle dispersion gel with easily controllable mesh size, a particle dispersion gel using the same, a method for producing a particle dispersion gel with easily controllable mesh size, and a method for producing a particle dispersion gel capable of improving the dispersibility of particles can be provided.

The following describes the implementation of the present invention.

[Gel for particle dispersion] The gel for particle dispersion of the present embodiment comprises a polymer (A) and a solvent (B), and can disperse particles inside. The gel for particle dispersion forms a three-dimensional network structure by the polymer (A), and the network structure contains a solvent (B), and the solvent (B) contains a polyol compound (B1).

As described above, in order to improve the balance between the dispersibility and retention of the enclosed particles, a particle dispersion gel that can control the mesh size according to the size of the enclosed particles is sought. The inventors of the present invention have repeatedly conducted intensive research to achieve the above-mentioned topic. As a result, it was found that in a particle dispersion gel comprising a polymer (A) and a solvent (B), the mesh size can be easily controlled by including a polyol compound (B1) as a solvent (B). Specifically, the particle dispersion gel of the present embodiment can easily control the mesh size of the three-dimensional network structure of the particle dispersion gel by changing the concentration of the polymer (A) or the type of the polyol compound (B1).

Hereinafter, each component constituting the particle dispersion gel of the present embodiment will be described in detail.

(Polymer (A)) The particle dispersion gel of the present embodiment includes a polymer (A). The polymer (A) is a polymer that forms a three-dimensional network structure in the particle dispersion gel of the present embodiment. The polymer (A) is not particularly limited, as long as it can be gelled and form a three-dimensional network structure by containing a solvent (B). It is preferably one or more selected from the group consisting of polysaccharides, proteins, peptides, (meth)acrylic polymers, polyvinyl alcohol polymers, and polyvinyl pyrrolidone, etc., and more preferably one or more selected from the group consisting of polysaccharides, (meth)acrylic polymers, polyvinyl alcohol polymers, and polyvinyl pyrrolidone, etc., and further preferably one or more selected from the group consisting of polysaccharides, polyvinyl alcohol polymers, and polyvinyl pyrrolidone, etc. More than two kinds, more preferably polysaccharides, more preferably water-soluble polysaccharides, more preferably tremella polysaccharides, hyaluronic acid, safflower gum, alginic acid, guar gum, cationized guar gum, carrageenan, gellan gum, agarose, carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, and cellulose nanofibers, etc. One or more water-soluble celluloses selected from the group consisting of carboxymethyl cellulose, hydroxypropyl cellulose, and hydroxyethyl cellulose, etc., and more preferably hydroxypropyl cellulose. Hydroxypropyl cellulose is a water-soluble cellulose derivative, which is usually obtained by treating cellulose with a base such as sodium hydroxide and then reacting it with an etherifying agent such as propylene oxide. Hydroxypropyl cellulose can be purchased from Fuji Film Co., Ltd. and Koh Pure Chemical Industries, Ltd., for example.

From the viewpoint of further improving the mobility of the particles contained in the gel, the polymer (A) preferably contains 30% by mass or more, more preferably 40% by mass or more, further preferably 50% by mass or more, further preferably 60% by mass or more, further preferably 80% by mass or more of hydroxypropyl cellulose, and preferably contains 100% by mass or less.

From the viewpoint of increasing the gel viscosity and further reducing the mesh size, the content of the polymer (A) in the particle dispersion gel of the present embodiment is preferably 0.01 mass % or more, more preferably 0.05 mass % or more, further preferably 0.1 mass % or more, further preferably 0.2 mass % or more, further preferably 0.3 mass % or more, and from the viewpoint of further increasing the mesh size, it is preferably 20.0 mass % or less, more preferably 15.0 mass % or less, further preferably 10.0 mass % or less, further preferably 5.0 mass % or less, further preferably 2.5 mass % or less, further preferably 1.5 mass % or less, further preferably 1.0 mass % or less, further preferably 0.8 mass % or less.

(Solvent (B)) The particle dispersion gel of the present embodiment contains a polyol compound (B1) as a solvent (B). The polyol compound (B1) is not particularly limited as long as it can be gelled together with the polymer (A) to form a three-dimensional network structure. From the viewpoint of further improving the controllability of the mesh size of the particle dispersion gel, it is preferably a diol compound (B2) containing 2 to 6 carbon atoms, more preferably one or more selected from the group consisting of ethylene glycol, 1,3-propylene glycol, 1,4-butylene glycol, 1,5-pentanediol and 1,6-hexanediol, and more preferably one or more selected from the group consisting of 1,3-propylene glycol, 1,4-butylene glycol, 1,5-pentanediol and 1,6-hexanediol.

The particle dispersion gel of the present embodiment may also contain a solvent other than the polyol compound (B1) as the solvent (B). The solvent other than the polyol compound (B1) is not particularly limited, and examples thereof include methanol, ethanol, isopropyl alcohol (IPA), N,N-dimethylformamide (DMF), dimethyl sulfoxide (DMSO), N,N-dimethylacetamide, tetrahydrofuran (THF), acetone, methyl ethyl ketone (MEK), cyclohexanone, ethyl acetate, acetonitrile, dichloromethane, chloroform, toluene, acetic acid, 1-methoxy-2-propanol (PGME), water, etc., and they may be used alone or in combination of two or more.

From the viewpoint of further improving the controllability of the mesh size of the particle dispersion gel, the solvent (B) preferably contains 30 mass % or more, more preferably 40 mass % or more, further preferably 50 mass % or more, further preferably 60 mass % or more, further preferably 80 mass % or more of the polyol compound (B1), and preferably contains 100 mass % or less.

From the viewpoint of further increasing the mesh size, further improving the gel strength, and further improving the mobility of the particles contained in the gel, the boiling point of the solvent (B) is preferably 180°C or higher, more preferably 190°C or higher, further preferably 195°C or higher, further preferably 200°C or higher, further preferably 210°C or higher, further preferably 220°C or higher. From the viewpoint of further reducing the mesh size or further improving the dispersibility and retention of the particles contained in the gel, the temperature is preferably below 300°C, more preferably below 280°C, further preferably below 260°C, further preferably below 255°C, further preferably below 245°C.

From the viewpoint of further increasing the mesh size or further improving the gel strength, and from the viewpoint of further improving the mobility of the particles contained in the gel, the viscosity of the solvent (B) measured by a B-type viscometer at 25°C and a rotation speed of 30 rpm is preferably 1 mPa･s or more, more preferably 5 mPa･s or more, further preferably 10 mPa･s or more, further preferably 15 mPa･s or more, further preferably 20 mPa･s or more. From the viewpoint of further reducing the mesh size or further improving the dispersibility and retention of the particles contained in the gel, it is preferably 200 mPa･s or less, more preferably 150 mPa･s or less, further preferably 100 mPa･s or less, further preferably 80 mPa･s or less. mPa･s or less.

From the viewpoint of further increasing the mesh size or further improving the gel strength or further improving the mobility of the particles contained in the gel, the molecular weight of the polyol compound (B1) is preferably 50 or more, more preferably 60 or more, further preferably 70 or more, further preferably 75 or more, further preferably 80 or more, further preferably 85 or more. From the viewpoint of further reducing the mesh size or further improving the dispersibility and retention of the particles contained in the gel, it is preferably 300 or less, more preferably 250 or less, further preferably 200 or less, further preferably 150 or less, further preferably 130 or less, further preferably 110 or less.

From the viewpoint of further improving the mobility of the particles contained in the gel or the viewpoint of further improving the stability of the gel, the viscosity of the particle dispersion gel of the present embodiment measured by a cone plate viscometer at 25°C, cone 2°/20 mm, and shear rate 15 s ^-1 is preferably 10 mPa･s or more, more preferably 50 mPa･s or more, further preferably 100 mPa･s or more, further preferably 200 mPa･s or more, further preferably 300 mPa･s or more, further preferably 400 mPa･s or more, and preferably 60000 mPa･s or less, more preferably 30000 mPa･s or less, further preferably 5000 mPa･s or less, further preferably 2000 mPa･s or less, more preferably 1500 mPa･s or less, further preferably 1000 mPa･s or less, further preferably 800 mPa･s or less.

When the mode particle size of the above-mentioned three-dimensional network structure measured by the photon correlation method according to JIS Z 8826:2019 is set to X ₁ (nm), and the median particle size of the above-mentioned three-dimensional network structure measured by the photon correlation method according to JIS Z 8826:2019 is set to (X ₂ ) (nm), X ₁ /X ₂ is preferably 0.20 or more and 2.0 or less. For the particle dispersion gel, it is required to improve the dispersibility of the particles contained therein. The inventors of the present invention have repeatedly conducted intensive studies to improve the dispersibility of the particles contained in the particle dispersion gel. As a result, it was found that in a particle dispersing gel having a three-dimensional network structure, by setting the ratio of the modal particle size to the median particle size of the three-dimensional network structure to a specific range, the dispersibility of the particles contained therein can be further improved. Specifically, the particle dispersing gel of the present embodiment can further improve the dispersibility of the particles contained therein by adjusting the above _X1 / _X2 to a range of 0.20 or more and 2.0 or less.

In the particle dispersing gel of the present embodiment, from the viewpoint of further improving the dispersibility of the particles contained therein, the above _X1 / _X2 is 0.20 or more, preferably 0.30 or more, more preferably 0.40 or more, further preferably 0.50 or more, further preferably 0.60 or more, and is 2.0 or less, preferably 1.8 or less, further preferably 1.7 or less, further preferably 1.6 or less.

From the viewpoint of further improving the mobility and dispersibility of the particles contained in the gel, the maximum frequency particle size (X1) of the three-dimensional network structure in the particle dispersion gel of the present embodiment measured by the photon correlation method according to JIS Z 8826: ₂₀₁₉ is preferably 10 nm or more, more preferably 20 nm or more, further preferably 50 nm or more, further preferably 70 nm or more, further preferably 100 nm or more, further preferably 200 nm or more, further preferably 300 nm or more, further preferably 400 nm or more. From the viewpoint of further improving the retention of the particles contained in the gel and the gel strength, it is preferably 10000 nm or less, more preferably 5000 nm or less, further preferably 2000 nm or less. nm or less, more preferably 1500 nm or less, and further preferably 1000 nm or less.

From the viewpoint of further improving the mobility and dispersibility of the particles contained in the gel, the median particle size (X 2 ₎ of the three-dimensional network structure in the particle dispersion gel of the present embodiment measured by the photon correlation method according to JIS Z 8826:2019 is preferably 50 nm or more, more preferably 70 nm or more, further preferably 80 nm or more, further preferably 100 nm or more, further preferably 200 nm or more, further preferably 300 nm or more, further preferably 400 nm or more, further preferably 500 nm or more. From the viewpoint of further improving the retention of the particles contained in the gel and the gel strength, it is preferably 10000 nm or less, more preferably 5000 nm or less, further preferably 2000 nm or less. nm or less, further preferably 1500 nm or less, further preferably 1000 nm or less, further preferably 800 nm or less.

As the use of the particle dispersion gel of the present embodiment, for example, it can be selected from one or more of the group consisting of wiring repair materials, artificial tissue materials, regenerative stent materials, sealing materials, anti-adhesion materials, drug delivery materials, contact lens materials, sensor materials, surface coating materials, separation materials, antibacterial materials, deodorizing materials, wound covering materials, catalysts, antiviral agents and antifungal agents. Among them, the particle dispersion gel of the present embodiment is preferably used as a gel constituting a wiring repair material.

The particles contained in the particle dispersion gel of the present embodiment can be appropriately selected according to the purpose of the particle dispersion gel, so there is no particular limitation. For example, one or more of the group consisting of drugs, fragrances, antibacterial agents, bactericides, cells, metal particles, inorganic particles, polymer particles, catalysts, antiviral agents and antifungal agents can be cited. Among them, the particles contained in the particle dispersion gel of the present embodiment are preferably metal particles, more preferably conductive metal microparticles, and more preferably conductive metal microparticles containing one or more of the group consisting of copper, gold, silver and aluminum, and more preferably copper microparticles. In addition, the above-mentioned metal particles may also contain the above-mentioned metal only on their surfaces.

The wiring repair material is used in self-repairing wiring that can self-repair when a disconnection occurs in the electrical wiring, for example, and includes a particle dispersion gel and conductive metal particles. The conductive metal particles are dispersed in the particle dispersion gel. With respect to the self-repairing wiring, when a disconnection occurs in the wiring, the wiring repair material is used to repair it. When the disconnection is covered with the wiring repair material, a portion of the conductive metal particles short-circuits the disconnection, thereby energizing the disconnection.

[Method for producing a particle dispersion gel] The particle dispersion gel of the present embodiment can be obtained, for example, by a production method comprising the following steps: obtaining a gel by mixing a polymer (A) and a solvent (B); and obtaining a particle dispersion gel having a three-dimensional network structure by kneading the gel.

For a gel having a three-dimensional network structure, for example, from the viewpoint of improving the dispersibility of particles contained therein, it is required to improve the uniformity of the mesh size. The inventors of the present invention have repeatedly conducted intensive research to achieve the above-mentioned subject. As a result, it was found that the uniformity of the mesh size of the gel can be improved by further kneading the gel-like material obtained by mixing the polymer (A) and the solvent (B). Specifically, the uniformity of the mesh size of the gel can be improved by kneading the gel-like material obtained by mixing the polymer (A) and the solvent (B).

(Step of obtaining a gel-like substance) In the step of obtaining a gel-like substance in the particle dispersion gel of the present embodiment, a gel-like substance is obtained by mixing a polymer (A) and a solvent (B). For example, a gel-like substance can be obtained by the following procedure. First, a polymer (A) and a solvent (B) are mixed. As polymer (A) and solvent (B), the above-mentioned ones can be used. Then, the obtained mixture is heated to about 40 to 100°C while stirring. The heating time is not particularly limited, as long as the mixture is appropriately gelled, for example, about 1 to 60 minutes. Furthermore, even without heating (room temperature), the mixture will gel if sufficient time is spent. Then, stop heating and stirring and let stand to obtain a gel-like substance.

(Step of obtaining a particle dispersion gel) Then, the above-mentioned gel-like material is kneaded to obtain a particle dispersion gel having a three-dimensional network structure. As a method for kneading the above-mentioned gel-like material, from the viewpoint of further improving the uniformity of the three-dimensional network structure in the particle dispersion gel of this embodiment, it is preferred to use at least one selected from the group consisting of a roll mill and a ball mill for kneading, and it is more preferred to use a roll mill for kneading.

The roller mill of this embodiment preferably comprises three or more rollers, and more preferably a three-roller mill. This allows the gel-like material to be mixed continuously, thereby further improving the productivity of the obtained particle dispersion gel.

[Particle dispersion gel] The particle dispersion gel of this embodiment includes the particle dispersion gel of this embodiment and particles (C) dispersed in the particle dispersion gel. From the viewpoint of increasing gel viscosity and further reducing mesh size, the content of polymer (A) in the particle dispersion gel of the present embodiment is preferably 0.01 mass % or more, more preferably 0.05 mass % or more, further preferably 0.1 mass % or more, further preferably 0.2 mass % or more, further preferably 0.3 mass % or more, and from the viewpoint of further increasing mesh size, it is preferably 20.0 mass % or less, more preferably 15.0 mass % or less, further preferably 10.0 mass % or less, further preferably 5.0 mass % or less, further preferably 2.5 mass % or less, further preferably 1.5 mass % or less, further preferably 1.0 mass % or less, further preferably 0.8 mass % or less. The content of the above particles (C) in the particle dispersion gel of the present embodiment can be appropriately selected according to the purpose of the particle dispersion gel or the type of particles (C) contained therein, and is therefore not particularly limited. When the entire particle dispersion gel is set to 100 mass%, it is, for example, 0.01 mass% or more, preferably 0.02 mass% or more, more preferably 0.05 mass% or more, and further preferably 0.3 mass% or more, and, for example, 30 mass% or less, preferably 10 mass% or less, more preferably 5 mass% or less, further preferably 1 mass% or less, and further preferably 0.5 mass% or less.

As the use of the particle dispersion gel of the present embodiment, for example, one or more of the group consisting of wiring repair materials, artificial tissue materials, regenerative stent materials, sealing materials, anti-adhesion materials, drug delivery materials, contact lens materials, sensor materials, surface coating materials, separation materials, antibacterial materials, deodorizing materials, wound covering materials, catalysts, antiviral agents and antifungal agents can be cited. Among them, the particle dispersion gel of the present embodiment is preferably used as a wiring repair material.

The particles (C) used in the particle dispersion gel of the present embodiment can be appropriately selected according to the purpose of the particle dispersion gel, so there is no particular limitation. For example, one or two or more selected from the group consisting of drugs, fragrances, antibacterial agents, bactericides, cells, metal particles, inorganic particles, polymer particles, catalysts, antiviral agents and antifungal agents can be cited. Among them, the particles (C) used in the particle dispersion gel of the present embodiment are preferably metal particles, more preferably conductive metal microparticles, and more preferably conductive metal microparticles containing one or two or more selected from the group consisting of copper, gold, silver and aluminum, and more preferably copper microparticles. In addition, the above-mentioned metal particles may also contain the above-mentioned metal only on their surfaces.

From the viewpoint of further improving the mobility and dispersibility of the particles (C), the median particle size _D50 of the particles (C) measured by the laser diffraction scattering method is preferably 0.01 μm or more, more preferably 0.05 μm or more, further preferably 0.1 μm or more, further preferably 0.3 μm or more. From the viewpoint of further improving the retention of the particles (C), it is preferably 10 μm or less, more preferably 5 μm or less, further preferably 3 μm or less, further preferably 1 μm or less.

[Method for producing particle-dispersed gel] The particle-dispersed gel of the present embodiment can be obtained, for example, by kneading the particle-dispersed gel of the present embodiment and the above-mentioned particles (C). As a method for kneading the particle-dispersed gel of the present embodiment and the above-mentioned particles (C), from the viewpoint of further improving the dispersibility of the particles (C) in the particle-dispersed gel of the present embodiment, kneading using at least one selected from the group consisting of a roll mill and a ball mill is preferred, and kneading using a roll mill is more preferred.

The roller mill of this embodiment preferably comprises three or more rollers, and more preferably a three-roller mill. In this way, the particle dispersion gel of this embodiment and the above particles can be continuously mixed, thereby further improving the productivity of the obtained particle dispersion gel.

Furthermore, the particle-dispersed gel of the present embodiment can also be obtained, for example, by a manufacturing method comprising the following steps: obtaining a gel-like substance by mixing a polymer (A), a solvent (B) and particles (C); and obtaining a particle-dispersed gel having a three-dimensional network structure by kneading the above-mentioned gel-like substance.

According to the method for producing a particle dispersion gel of the present embodiment, the dispersibility of the particles (C) can be improved by further kneading the gel-like material obtained by mixing the polymer (A), the solvent (B) and the particles (C). Specifically, the uniformity of the mesh size of the gel can be improved by further kneading the gel-like material obtained by mixing the polymer (A), the solvent (B) and the particles (C).

The particle dispersion gel obtained by the method for producing the particle dispersion gel of the present embodiment, for example, forms a three-dimensional network structure with the polymer (A), and the network structure contains the solvent (B), and the particles (C) are enclosed in the network structure.

(Step of obtaining a gel-like substance) In the method for producing a particle-dispersed gel of the present embodiment, in the step of obtaining a gel-like substance, a polymer (A), a solvent (B) and particles (C) are mixed to obtain a gel-like substance. For example, a gel-like substance can be obtained by the following procedure. First, a polymer (A), a solvent (B) and particles (C) are mixed. As polymer (A) and solvent (B), the above-mentioned ones can be used. Then, the obtained mixture is heated to about 40 to 100°C while stirring. The heating time is not particularly limited, as long as the mixture is appropriately gelled, for example, about 1 to 60 minutes. Furthermore, even without heating (room temperature), the mixture will gel if sufficient time is spent. Then, stop heating and stirring and let stand to obtain a gel-like substance.

(Step of obtaining a particle-dispersed gel) Then, the above-mentioned gel-like material is kneaded to obtain a particle-dispersed gel having a three-dimensional network structure. As a kneading method for the above-mentioned gel-like material, from the viewpoint of further improving the uniformity of the three-dimensional network size in the particle-dispersed gel of this embodiment, it is preferred to use at least one selected from the group consisting of a roll mill and a ball mill for kneading, and it is more preferred to use a roll mill for kneading.

The roller mill of this embodiment preferably comprises three or more rollers, and more preferably a three-roller mill. This allows the gel-like material to be mixed continuously, thereby further improving the productivity of the obtained particle-dispersed gel.

The above is a description of the embodiments of the present invention, but these are merely examples of the present invention, and various configurations other than the above may be adopted within the scope of not impairing the effects of the present invention.

Furthermore, the present invention is not limited to the above-mentioned implementation methods, and changes and improvements within the scope of achieving the purpose of the present invention are included in the present invention. Example

Hereinafter, the present invention will be described in detail with reference to embodiments, but the present invention is not limited in any way to the description of these embodiments.

[Materials] Details of the materials used to produce the particle dispersion gel are as follows. (Polymer (A)) ･Hydroxypropylcellulose (manufactured by Fuji Film Wako Pure Chemical Industries, Ltd.)

(Solvent (B)) ･Ethylene glycol (molecular weight: 62.07, boiling point: 198℃, manufactured by Fuji Film Wako Jun Chemical Co., Ltd.) ･1,3-Propanediol (molecular weight: 76.09, boiling point: 214℃, manufactured by Fuji Film Wako Jun Chemical Co., Ltd.) ･1,4-Butanediol (molecular weight: 90.12, boiling point: 230℃, manufactured by Fuji Film Wako Jun Chemical Co., Ltd.) ･1,5-Pentanediol (molecular weight: 104.15, boiling point: 242℃, manufactured by Fuji Film Wako Jun Chemical Co., Ltd.) ･1,6-Hexanediol (molecular weight: 118.17, boiling point: 250℃, manufactured by Fuji Film Wako Jun Chemical Co., Ltd.)

(Particles (C)) ･Copper particles: (Metallic copper powder manufactured by FURUKAWA CHEMICALS, product number: FMC-SB, median particle size D ₅₀ measured by laser diffraction scattering method: 0.7 μm)

[Measurement and Evaluation] In this embodiment, various measurements and evaluations are performed by the following methods.

(Viscosity of solvent (B)) Use a B-type viscometer (manufactured by Toki Sangyo Co., Ltd., product name: TVB-10M, rotor No. 1) to measure the viscosity of solvent (B) at 25°C, rotation speed 30 rpm, and solvent (B) 200 mL. Here, when a mixed solvent of two or more is used as solvent (B), the viscosity of the mixed solvent is measured.

(Viscosity of the gel for particle dispersion) The viscosity of the gel was measured using a cone plate viscometer (manufactured by Spectris Corporation, product name: Kinexus pro+) at 25°C, cone 2°/20 mm, and shear rate 15 s ^-1 .

(Mode particle size (X ₁ ), median particle size (X ₂ ) and half-value width of the three-dimensional network structure of the particle dispersion gel) The mode particle size (X ₁ ), median particle size (X ₂ ) and half-value width of the three-dimensional network structure of the particle dispersion gel were measured by the photon correlation method in accordance with JIS Z 8826:2019. As a measuring device, a nanoparticle analyzer SZ-100V2 gel unit manufactured by HORIBA was used. As measurement conditions, the measurement range was set to 0.3 nm to 10 μm, the distribution form was set to polydisperse and wide distribution, and the laser irradiation position was set to 10 points (0 to 900 μm) with a step size of 100 μm. When bubbles are mixed into the sample when it is put into the measuring tank, defoaming treatment is performed. In addition, the half-value width of the grid size distribution curve of the obtained three-dimensional network structure is calculated. The above half-value width is calculated by calculating the grid size (nm) at which the frequency (%) of the two grid size distribution curves is half of the maximum value, and the difference between them is set as the half-value width.

(Evaluation of particle dispersibility) 50 g of the particle dispersion gel obtained in Examples 11 to 16 and 20 mg of copper particles as particles (C) were fully mixed to obtain a mixture. Then, 50 g of the obtained mixture was passed through a three-roll mill (BR-150V manufactured by AIMEX) once to obtain a copper particle dispersion gel. Here, the passing of the first to third rolls of the three-roll mill was set to 1 time. Each roll had a diameter of 63.5 mm, and the distance between the rolls was set to 10 μm. In addition, the rotation speed of the first roll: the rotation speed of the second roll: the rotation speed of the third roll = 1.0:2.4:6.0, and the rotation speed of the third roll was set to 80 rpm. The obtained copper particle dispersion gel was evaluated for dispersibility as follows. First, 50 g of the obtained copper particle dispersion gel was left to stand for 24 hours, and the dispersibility of the copper particles was evaluated visually according to the following criteria. A (good dispersibility): The copper particles were uniformly dispersed in the gel, and the dispersibility of the copper particles was good (the gel turned reddish brown as a whole). B (poor dispersibility): The copper particles were concentrated in the gel, and the dispersibility of the copper particles was poor (the gel turned reddish brown as a whole, but the color tone was dark and light).

(Evaluation of the dispersibility of copper particles) 50 g of the copper particle dispersion gel obtained in Examples 19 and 20 was left to stand for 24 hours, and the dispersibility of the copper particles was evaluated by visual inspection.

Example 1 First, hydroxypropyl cellulose as a polymer (A) and ethylene glycol as a solvent (B) are fully mixed to obtain a mixture. The amounts of polymer (A) and solvent (B) are as shown in Table 1. The obtained mixture is heated at 50°C for 2 minutes while being stirred. The mixture is thereby turned into a gel. After the heating is stopped, the obtained gel is allowed to stand at room temperature (23°C). Then, 100 g of the gel at room temperature is passed through a three-roll mill (BR-150V manufactured by AIMEX) 4 times to obtain a gel for particle dispersion. Here, the number of passes of the first to third rolls of the three-roll mill is set to 1. Each roller has a diameter of 63.5 mm and the distance between the rollers is set to 10 μm. In addition, the rotation speed of the first roller: the rotation speed of the second roller: the rotation speed of the third roller is set to 1.0:2.4:6.0, and the rotation speed of the third roller is set to 80 rpm. The above measurements were performed on the obtained particle dispersion gel. The results are shown in Table 1.

Examples 2 to 10 Except that the composition of the polymer (A) and the solvent (B) was changed to the composition shown in Table 1, the particle dispersion gel was obtained in the same manner as in Example 1. The above-mentioned measurements were performed on the obtained particle dispersion gel. The results are shown in Table 1.

[Table 1] Table 1 ＜Composition of particle dispersion gel＞ Unit Embodiment 1 Embodiment 2 Embodiment 3 Embodiment 4 Embodiment 5 Embodiment 6 Embodiment 7 Embodiment 8 Embodiment 9 Embodiment 10 Polymer (A) Hydroxypropyl cellulose Quality 0.5 0.5 0.5 0.5 0.5 0.1 2.0 3.0 5.0 7.0 Solvent (B) Ethylene glycol Quality 99.5 49.75 99.9 98.0 97.0 95.0 93.0 1,3-Propanediol Quality 99.5 1,4-Butanediol Quality 99.5 1,5-Pentanediol Quality 99.5 1,6-Hexanediol Quality 49.75 Viscosity of solvent (B) mPa･s 16 36 62 93 25 16 16 16 16 16 Gel viscosity mPa･s 279 540 713 852 470 33 7990 20100 50300 43200 The most frequent particle size of the three-dimensional network structure (X ₁ ) nm 54 81 480 561 851 324 47 47 36 31 Median particle size in three-dimensional network structure (X ₂ ) nm 473 99 683 654 563 491 68 56 41 36

From Table 1, it can be seen that the mesh size of the particle dispersing gel can be changed by changing the type of the polyol compound (B1) or the concentration of the polymer (A). That is, it can be seen that the mesh size of the particle dispersing gel of the present embodiment is easily controlled.

Example 11 First, hydroxypropyl cellulose as a polymer (A) and ethylene glycol as a solvent (B) are fully mixed to obtain a mixture. The amounts of polymer (A) and solvent (B) are as shown in Table 2. The obtained mixture is heated at 50°C for 2 minutes while being stirred. Thereby, the mixture becomes a gel. After the heating is stopped, the obtained gel is allowed to stand at room temperature (23°C). Then, 100 g of the gel at room temperature is passed through a three-roll mill (BR-150V manufactured by AIMEX) 4 times to obtain a gel for particle dispersion. Here, the passing of the first to third rolls of the three-roll mill is set to 1 time. Each roller has a diameter of 63.5 mm and the distance between the rollers is set to 10 μm. In addition, the rotation speed of the first roller: the rotation speed of the second roller: the rotation speed of the third roller is set to 1.0:2.4:6.0, and the rotation speed of the third roller is set to 80 rpm. The above measurements were performed on the obtained particle dispersion gel. The results are shown in Table 2.

Examples 12 to 16 Except that the composition of the polymer (A) and the solvent (B) was changed to the composition shown in Table 2, the particle dispersion gel was obtained in the same manner as in Example 11. The above-mentioned measurements were performed on the obtained particle dispersion gel. The results are shown in Table 2.

[Table 2] Table 2 ＜Composition of particle dispersion gel＞ Unit Embodiment 11 Embodiment 12 Embodiment 13 Embodiment 14 Embodiment 15 Embodiment 16 Polymer (A) Hydroxypropyl cellulose Quality 0.5 0.5 0.5 0.5 0.5 0.1 Solvent (B) Ethylene glycol Quality 99.5 49.75 99.9 1,3-Propanediol Quality 99.5 1,4-Butanediol Quality 99.5 1,5-Pentanediol Quality 99.5 1,6-Hexanediol Quality 49.75 Viscosity of solvent (B) mPa･s 16 36 62 93 25 16 Gel viscosity mPa･s 279 540 713 852 470 33 The most frequent particle size of the three-dimensional network structure (X ₁ ) nm 54 81 480 561 851 324 Median particle size in three-dimensional network structure (X ₂ ) nm 473 99 683 654 563 491 _X1 / _X2 - 0.11 0.83 0.70 0.86 1.51 0.66 Particle dispersion evaluation - B A A A A A

According to Table 2, it can be seen that the particle dispersing gels of Examples 12 to 16 with _X1 / _X2 of 0.20 or more and 2.0 or less can improve the dispersibility of the particles contained therein, compared with the particle dispersing gel of Example 11 with _X1 / _X2 less than 0.20. In other words, it can be seen that the particle dispersing gels with _X1 / _X2 of 0.20 or more and 2.0 or less can improve the dispersibility of the particles contained therein.

Example 17 First, hydroxypropyl cellulose as a polymer (A) and 1,3-propylene glycol as a solvent (B) are fully mixed to obtain a mixture. The amounts of polymer (A) and solvent (B) are as shown in Table 3. The obtained mixture is heated at 50°C for 2 minutes while being stirred. Thereby, the mixture becomes a gel. After the heating is stopped, the obtained gel is allowed to stand at room temperature (23°C). Then, 100 g of the gel at room temperature is passed through a three-roll mill (BR-150V manufactured by AIMEX) 4 times to obtain a gel. Here, the passing of the first to third rolls of the three-roll mill is set to 1 time. Each roller has a diameter of 63.5 mm and the distance between the rollers is set to 10 μm. In addition, the rotation speed of the first roller: the rotation speed of the second roller: the rotation speed of the third roller is set to 1.0:2.4:6.0, and the rotation speed of the third roller is set to 80 rpm. The above measurements were performed on the obtained gels. The results are shown in Table 3.

Example 18 First, hydroxypropyl cellulose as a polymer (A) and 1,3-propylene glycol as a solvent (B) are fully mixed to obtain a mixture. The amounts of polymer (A) and solvent (B) are as shown in Table 3. The obtained mixture is heated at 50°C for 2 minutes while being stirred. Thus, the mixture becomes a gel. After the heating is stopped, the obtained gel is left to stand at room temperature (23°C) to obtain a gel. The above-mentioned measurements are performed on the obtained gels. The results are shown in Table 3.

[Table 3] Table 3 ＜Gel composition＞ Unit Embodiment 17 Embodiment 18 Polymer (A) Hydroxypropyl cellulose Quality 0.5 0.5 Solvent (B) 1,3-Propanediol Quality 99.5 99.5 Viscosity of solvent (B) mPa･s 36 36 The most frequent particle size of the three-dimensional network structure (X ₁ ) nm 81 83 Median particle size in three-dimensional network structure (X ₂ ) nm 99 62 Half-value width of the grid size distribution curve nm 150 171

According to Table 3, it can be seen that the half-value width of the mesh size distribution curve of the gel obtained by the manufacturing method of Example 17 is smaller, and the uniformity of the mesh size of the gel is improved compared with the gel obtained by the manufacturing method of Example 18. That is, it can be seen that by kneading the gel-like material obtained by mixing the polymer (A) and the solvent (B), the uniformity of the mesh size of the obtained gel can be improved.

Example 19 First, 0.5 g of hydroxypropyl cellulose as a polymer (A), 50 g of ethylene glycol as a solvent (B), and 20 mg of copper particles as particles (C) are fully mixed to obtain a mixture. The obtained mixture is heated at 50°C for 2 minutes while being stirred. Thereby, the mixture becomes a gel. After the heating is stopped, the obtained gel is allowed to stand at room temperature (23°C). Then, 50 g of the gel at room temperature is passed through a three-roll mill (BR-150V manufactured by AIMEX) 4 times to obtain a copper particle dispersed gel. Here, the passing of the first to third rolls of the three-roll mill is set to 1 time. Each roller used had a diameter of 63.5 mm, and the distance between the rollers was set to 10 μm. In addition, the rotation speed of the first roller: the rotation speed of the second roller: the rotation speed of the third roller was set to 1.0:2.4:6.0, and the rotation speed of the third roller was set to 80 rpm. The copper particle dispersion gel obtained was evaluated for the dispersibility of the copper particles. As a result, the copper particles were uniformly dispersed in the gel, and the dispersibility of the copper particles was good (the gel turned reddish brown as a whole).

Example 20 First, 0.5 g of hydroxypropyl cellulose as a polymer (A), 50 g of ethylene glycol as a solvent (B), and 20 mg of copper particles as particles (C) are fully mixed to obtain a mixture. The obtained mixture is heated at 50°C for 2 minutes while being stirred. The mixture is thereby turned into a gel. After the heating is stopped, the obtained gel is allowed to stand at room temperature (23°C) to obtain a copper particle dispersion gel. The copper particle dispersion gel obtained is evaluated for its dispersibility. As a result, the copper particles are concentrated in the gel, and the copper particles have poor dispersibility (the gel as a whole becomes reddish brown, but the color tone varies).

This application claims priority based on Japanese Patent Application No. 2022-126110, Japanese Patent Application No. 2022-126111, and Japanese Patent Application No. 2022-126112 filed on August 8, 2022, and all the contents disclosed in them are incorporated herein.

The present invention can also adopt the following aspects.

[1a] A particle dispersing gel comprising a polymer (A) and a solvent (B) and capable of dispersing particles therein, wherein the particle dispersing gel forms a three-dimensional network structure with the polymer (A), and the network structure contains the solvent (B), and the solvent (B) comprises a polyol compound (B1). [2a] The particle dispersing gel as described in [1a] above, wherein the molecular weight of the polyol compound (B1) is 50 to 300. [3a] The particle dispersing gel as described in [1a] or [2a] above, wherein the viscosity of the solvent (B) measured at 25°C and 30 rpm using a B-type viscometer is 1 to 200 mPa·s. [4a] The particle dispersion gel as described in any one of [1a] to [3a] above, wherein the boiling point of the solvent (B) is 180°C to 300°C. [5a] The particle dispersion gel as described in any one of [1a] to [4a] above, wherein the polyol compound (B1) comprises a diol compound (B2) having a carbon number of 2 to 6. [6a] The particle dispersion gel as described in any one of [1a] to [5a] above, wherein the polyol compound (B1) comprises one or more selected from the group consisting of ethylene glycol, 1,3-propylene glycol, 1,4-butylene glycol, 1,5-pentanediol and 1,6-hexanediol. [7a] The particle dispersion gel as described in any one of the above [1a] to [6a], wherein the viscosity of the particle dispersion gel measured by a cone viscometer at 25°C, cone 2°/20 mm, and shear rate 15 s ^-1 is 10 mPa･s or more and 60000 mPa･s or less. [8a] The particle dispersion gel as described in any one of the above [1a] to [7a], wherein the mode particle size (X ₁ ) of the three-dimensional network structure measured by the photon correlation method in accordance with JIS Z 8826 is 10 nm or more. [9a] The particle dispersion gel as described in any one of [1a] to [8a] above, wherein the median particle size ( _X2 ) of the three-dimensional network structure measured by the photon correlation method according to JIS Z 8826 is 50 nm or more. [10a] The particle dispersion gel as described in any one of [1a] to [9a] above, wherein the polymer (A) comprises one or more selected from the group consisting of polysaccharides, proteins, peptides, (meth)acrylic acid polymers, polyvinyl alcohol polymers and polyvinyl pyrrolidone. [11a] The particle dispersion gel as described in any one of [1a] to [10a] above, wherein the content of the polymer (A) in the particle dispersion gel is 0.01 mass % or more and 20.0 mass % or less. [12a] A particle dispersion gel comprising a particle dispersion gel as described in any one of [1a] to [11a] above, and particles dispersed in the particle dispersion gel. [13a] The particle dispersion gel as described in [12a] above, wherein the particles comprise one or more selected from the group consisting of drugs, fragrances, antibacterial agents, fungicides, cells, metal particles, inorganic particles, polymer particles, catalysts, antiviral agents and antifungal agents. [14a] The particle dispersion gel as described in [12a] or [13a] above, wherein the median particle size _D50 of the particles measured by laser diffraction scattering is not less than 0.01 μm and not more than 10 μm. [15a] A method for producing a particle dispersion gel, which is used to produce the particle dispersion gel described in any one of [1a] to [11a] above, and comprises the following steps: obtaining a gel-like substance by mixing the polymer (A) and the solvent (B); and obtaining a particle dispersion gel having a three-dimensional network structure by kneading the gel-like substance.

The present invention can also adopt the following aspects.

[1b] A particle dispersing gel comprising a polymer (A) and a solvent (B) and capable of dispersing particles therein, wherein the particle dispersing gel forms a three-dimensional network structure with the polymer (A), and the network structure contains the solvent (B), and when the mode particle size of the three-dimensional network structure measured by the photon correlation method in accordance with JIS Z 8826 is _X1 (nm), and when the median particle size of the three-dimensional network structure measured by the photon correlation method in accordance with JIS Z 8826 is ( _X2 ) (nm), _X1 / _X2 is 0.20 or more and 2.0 or less. [2b] The particle dispersing gel as described in [1b] above, wherein the solvent (B) comprises a polyol compound (B1). [3b] The particle dispersion gel as described in [2b] above, wherein the polyol compound (B1) comprises a diol compound (B2) having a carbon number of 2 or more and 6 or less. [4b] The particle dispersion gel as described in [2b] or [3b] above, wherein the polyol compound (B1) comprises one or more selected from the group consisting of ethylene glycol, 1,3-propylene glycol, 1,4-butylene glycol, 1,5-pentanediol and 1,6-hexanediol. [5b] The particle dispersion gel as described in any one of [1b] to [4b] above, wherein the maximum frequency particle size ( _X1 ) of the stereo network structure measured by the photon correlation method in accordance with JIS Z 8826 is 10 nm or more. [6b] The particle dispersion gel as described in any one of [1b] to [5b] above, wherein the median particle size ( _X2 ) of the three-dimensional network structure measured by the photon correlation method according to JIS Z 8826 is 50 nm or more. [7b] The particle dispersion gel as described in any one of [1b] to [6b] above, wherein the polymer (A) comprises one or more selected from the group consisting of polysaccharides, proteins, peptides, (meth)acrylic acid polymers, polyvinyl alcohol polymers and polyvinyl pyrrolidone. [8b] The particle dispersion gel as described in any one of [1b] to [7b] above, wherein the content of the polymer (A) in the particle dispersion gel is 0.01 mass % or more and 20.0 mass % or less. [9b] A particle dispersion gel comprising a particle dispersion gel as described in any one of [1b] to [8b] above, and particles dispersed in the particle dispersion gel. [10b] The particle dispersion gel as described in [9b] above, wherein the particles comprise one or more selected from the group consisting of drugs, fragrances, antibacterial agents, fungicides, cells, metal particles, inorganic particles, polymer particles, catalysts, antiviral agents and antifungal agents. [11b] The particle dispersion gel as described in [9b] or [10b] above, wherein the median particle size _D50 of the particles measured by laser diffraction scattering is not less than 0.01 μm and not more than 10 μm. [12b] A method for producing a particle dispersion gel, which is used to produce the particle dispersion gel described in any one of [1b] to [8b] above, and comprises the following steps: obtaining a gel-like substance by mixing the polymer (A) and the solvent (B); and obtaining a particle dispersion gel having a three-dimensional network structure by kneading the gel-like substance.

The present invention can also adopt the following aspects.

[1c] A method for producing a gel, which is a method for producing a gel having a three-dimensional network structure and comprising the following steps: obtaining a gel-like substance by mixing the polymer (A) and the solvent (B); and obtaining a gel having a three-dimensional network structure by kneading the gel-like substance. [2c] A method for producing a gel as described in [1c] above, wherein the gel forms a three-dimensional network structure by the polymer (A), and the solvent (B) is contained in the network structure. [3c] The method for producing a gel as described in [1c] or [2c] above, wherein in the step of kneading the gel-like material, the gel-like material is kneaded using a roll mill. [4c] The method for producing a gel as described in any one of [1c] to [3c] above, wherein the solvent (B) contains a polyol compound (B1). [5c] The method for producing a gel as described in [4c] above, wherein the polyol compound (B1) contains a diol compound (B2) having a carbon number of 2 or more and 6 or less. [6c] The method for producing a gel as described in [4c] or [5c] above, wherein the polyol compound (B1) contains one or more selected from the group consisting of ethylene glycol, 1,3-propylene glycol, 1,4-butylene glycol, 1,5-pentanediol and 1,6-hexanediol. [7c] The method for producing a gel as described in any one of [1c] to [6c] above, wherein the mode particle size (X ₁ ) of the stereo network structure measured by the photon correlation method according to JIS Z 8826 is 10 nm or more. [8c] The method for producing a gel as described in any one of [1c] to [7c] above, wherein the median particle size (X ₂ ) of the stereo network structure measured by the photon correlation method according to JIS Z 8826 is 50 nm or more. [9c] The method for producing a gel as described in any one of [1c] to [8c] above, wherein the polymer (A) comprises one or more selected from the group consisting of polysaccharides, proteins, peptides, (meth)acrylic acid polymers, polyvinyl alcohol polymers and polyvinyl pyrrolidone. [10c] A method for producing a gel as described in any one of [1c] to [9c] above, wherein the content of the polymer (A) in the gel is not less than 0.01 mass % and not more than 20.0 mass %. [11c] A method for producing a particle-dispersed gel, which is a method for producing a particle-dispersed gel having a three-dimensional network structure and comprises the following steps: obtaining a gel-like substance by mixing the polymer (A), the solvent (B) and the particles (C); and obtaining a particle-dispersed gel having a three-dimensional network structure by kneading the gel-like substance. [12c] A method for producing a particle-dispersed gel as described in [11c] above, wherein the particle-dispersed gel forms a three-dimensional network structure by the polymer (A), and the solvent (B) is contained in the network structure, and the particles (C) are enclosed in the network structure. [13c] A method for producing a particle-dispersed gel as described in [11c] or [12c] above, wherein in the step of kneading the gel-like substance, a roller mill is used to knead the gel-like substance. [14c] A method for producing a particle-dispersed gel as described in any one of [11c] to [13c] above, wherein the solvent (B) contains a polyol compound (B1). [15c] The method for producing a particle dispersion gel as described in [14c] above, wherein the polyol compound (B1) comprises a diol compound (B2) having a carbon number of 2 or more and 6 or less. [16c] The method for producing a particle dispersion gel as described in [14c] or [15c] above, wherein the polyol compound (B1) comprises one or more selected from the group consisting of ethylene glycol, 1,3-propylene glycol, 1,4-butylene glycol, 1,5-pentanediol and 1,6-hexanediol. [17c] The method for producing a particle dispersion gel as described in any one of [11c] to [16c] above, wherein the polymer (A) comprises one or more selected from the group consisting of polysaccharides, proteins, peptides, (meth)acrylic acid polymers, polyvinyl alcohol polymers and polyvinyl pyrrolidone. [18c] A method for producing a particle dispersion gel as described in any one of [11c] to [17c] above, wherein the content of the polymer (A) in the particle dispersion gel is 0.01 mass % to 20.0 mass %. [19c] A method for producing a particle dispersion gel as described in any one of [11c] to [18c] above, wherein the particles (C) comprise one or more selected from the group consisting of drugs, fragrances, antibacterial agents, fungicides, cells, metal particles, inorganic particles, polymer particles, catalysts, antiviral agents and antifungal agents. [20c] A method for producing a particle dispersion gel as described in any one of [11c] to [19c] above, wherein the median particle size _D50 of the above particles (C) measured by laser diffraction scattering method is not less than 0.01 μm and not more than 10 μm.

Claims (21)

A particle dispersing gel, which comprises a polymer (A) and a solvent (B) and can disperse particles inside. The particle dispersing gel forms a three-dimensional network structure by the polymer (A), and the network structure contains the solvent (B). The solvent (B) comprises a polyol compound (B1). The particle dispersion gel of claim 1, wherein the molecular weight of the polyol compound (B1) is 50 to 300. The particle dispersion gel of claim 1 or 2, wherein the viscosity of the solvent (B) measured by a B-type viscometer at 25°C and a rotation speed of 30 rpm is 1 mPa･s or more and 200 mPa･s or less. The particle dispersion gel of claim 1 or 2, wherein the boiling point of the solvent (B) is not less than 180°C and not more than 300°C. The particle dispersion gel of claim 1 or 2, wherein the polyol compound (B1) comprises a diol compound (B2) having a carbon number of 2 to 6. The particle dispersion gel of claim 1 or 2, wherein the polyol compound (B1) comprises one or more selected from the group consisting of ethylene glycol, 1,3-propylene glycol, 1,4-butanediol, 1,5-pentanediol and 1,6-hexanediol. The particle dispersion gel of claim 1 or 2, wherein the viscosity of the particle dispersion gel measured by a cone plate viscometer at 25°C, cone 2°/20 mm, and shear rate 15 s ^-1 is not less than 10 mPa･s and not more than 60000 mPa･s. In the particle dispersion gel of claim 1 or 2, when the mode particle size of the stereo-network structure measured by the photon correlation method in accordance with JIS Z 8826:2019 is X ₁ (nm), and the median particle size of the stereo-network structure measured by the photon correlation method in accordance with JIS Z 8826:2019 is (X ₂ ) (nm), X ₁ /X ₂ is 0.20 or more and 2.0 or less. The particle dispersion gel of claim 1 or 2, wherein the mode particle size (X ₁ ) of the three-dimensional network structure measured by a photon correlation method according to JIS Z 8826:2019 is 10 nm or more. The particle dispersion gel of claim 1 or 2, wherein the median particle size (X ₂ ) of the three-dimensional network structure measured by a photon correlation method according to JIS Z 8826:2019 is 50 nm or more. The particle dispersion gel of claim 1 or 2, wherein the polymer (A) comprises one or more selected from the group consisting of polysaccharides, proteins, peptides, (meth)acrylic acid polymers, polyvinyl alcohol polymers and polyvinyl pyrrolidone. The particle dispersion gel of claim 1 or 2, wherein the content of the polymer (A) in the particle dispersion gel is 0.01 mass % to 20.0 mass %. A particle dispersion gel comprising the particle dispersion gel according to any one of claims 1 to 12, and particles (C) dispersed in the particle dispersion gel. The particle dispersion gel of claim 13, wherein the particles (C) comprise one or more selected from the group consisting of drugs, fragrances, antibacterial agents, fungicides, cells, metal particles, inorganic particles, polymer particles, catalysts, antiviral agents and antifungal agents. The particle dispersion gel of claim 13 or 14, wherein the median particle size _D50 of the above-mentioned particles (C) measured by laser diffraction scattering method is not less than 0.01 μm and not more than 10 μm. A method for producing a particle dispersion gel, which is used to produce a particle dispersion gel as claimed in any one of claims 1 to 12, and comprises the following steps: obtaining a gel by mixing the polymer (A) and the solvent (B); and obtaining a particle dispersion gel having a three-dimensional network structure by kneading the gel. A method for producing a gel for particle dispersion as claimed in claim 16, wherein in the step of kneading the gel-like material, a roller mill is used to knead the gel-like material. A method for producing a particle dispersion gel, which is used to produce a particle dispersion gel as described in any one of claims 13 to 15, and includes the following steps: obtaining a gel by mixing the polymer (A), the solvent (B) and the particles (C); and obtaining a particle dispersion gel having a three-dimensional network structure by kneading the gel. A method for manufacturing a particle dispersion gel as claimed in claim 18, wherein the particle dispersion gel forms a three-dimensional network structure by the polymer (A), and the network structure contains the solvent (B), and the particles (C) are contained in the network structure. A method for producing a particle-dispersed gel as claimed in claim 18 or 19, wherein in the step of kneading the gel-like substance, a roller mill is used to knead the gel-like substance. A method for producing a particle dispersion gel as claimed in claim 18 or 19, wherein the content of the polymer (A) in the particle dispersion gel is greater than 0.01 mass % and less than 20.0 mass %.