TW202400612A - 作為HPK1抑制劑之四氫吡啶并[3,4-d]嘧啶化物 - Google Patents

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Publication number

TW202400612A

TW202400612A TW112114997A TW112114997A TW202400612A TW 202400612 A TW202400612 A TW 202400612A TW 112114997 A TW112114997 A TW 112114997A TW 112114997 A TW112114997 A TW 112114997A TW 202400612 A TW202400612 A TW 202400612A

Authority

TW

Taiwan

Prior art keywords

mmol

group

compound

pyrido

cancer

Prior art date

2022-05-10

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• QRLLENCJWMWNCY-UHFFFAOYSA-N 1,2,3,4-tetrahydropyrido[3,4-d]pyrimidine Chemical class C1=NC=C2NCNCC2=C1 QRLLENCJWMWNCY-UHFFFAOYSA-N 0.000 title abstract description 3
• 239000003112 inhibitor Substances 0.000 title abstract description 3
• 101100177670 Caenorhabditis elegans hpk-1 gene Proteins 0.000 title 1
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• HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims abstract description 17
• 208000027866 inflammatory disease Diseases 0.000 claims abstract description 10
• 101001059991 Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 1 Proteins 0.000 claims abstract 5
• 102100028199 Mitogen-activated protein kinase kinase kinase kinase 1 Human genes 0.000 claims abstract 5
• YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 284
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• LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims description 15
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