TW202400029A - Menopausal disorder improving agent - Google Patents

Abstract

This invention provides a novel menopausal disorder improving agent.

The menopausal disorder improving agent of the present invention contains powder or extract of Silkworm Bombyx mori. The menopausal disorder improving agent can bring about prevention or improvement of menopausal disorders. The menopausal disorder improving agent of the present invention is preferably in the form of a food composition, a dietary supplement composition, or a food additive.

Description

Menopausal disorder improving agent

The present invention relates to an agent for improving menopausal disorders.

Menopausal disorder refers to an unidentified clinical syndrome that occurs during menopause and is caused by autonomic nervous system or psychogenic factors. It not only causes physical problems caused by reduced production of endocrine hormones (follicle hormone; estrogen). Changes are also related to the pressure caused by environmental changes in society. In addition, in recent years, youthful menopausal disorder, which occurs in people in their 20s and 30s, has also attracted attention. Menopausal disorders manifest themselves in various symptoms, such as loss of muscle mass, nerve sensitivity, sleep disturbance, and accumulation of anxiety, restlessness, and fatigue. From this viewpoint, development of agents for improving menopausal disorders that can prevent or improve menopausal disorders has been widely pursued (for example, Patent Document 1, etc.).

[Prior technical literature]

[Patent Document]

Japanese Patent Application Publication No. 2020-156521

In view of the above-mentioned circumstances, an agent for improving menopausal disorders has been sought, and an object of the present invention is to provide a novel agent for improving menopausal disorders.

As a result of diligent research to achieve the above object, the present inventors discovered for the first time that powder or extract of Cordyceps sinensis can prevent or improve menopausal disorders, and completed the present invention.

That is, the present invention includes the subject matter described in the following items.

Item 1. A menopausal disorder ameliorating agent containing powder or extract of Cordyceps sinensis.

Item 2. The menopausal disorder improving agent as described in the above Item 1, which is used for a group selected from the group consisting of prevention or improvement of muscle mass loss, prevention or improvement of nervousness, suppression of anxiety, and suppression of depression. At least one of them.

Item 3. The agent for improving menopausal disorders as described in Item 1 or 2 above, which is in the form of a food or drink composition.

Item 4. The agent for improving menopausal disorders as described in Item 1 or 2 above, which is in the form of a nutritional supplement food and drink composition.

Item 5. The agent for improving menopausal disorders as described in the above Item 1 or Item 2, which is in the form of a food additive.

Item 6. Use of cordyceps sinensis powder or extract to produce the menopausal disorder improving agent described in any one of the above items 1 to 5.

Item 7. A method of administering Cordyceps sinensis powder or extract to subjects who need to prevent or improve menopausal disorders.

Item 8. A Cordyceps sinensis powder or extract, which is used to prevent or improve menopausal disorders.

The present invention can provide an agent for improving menopausal disorders. The menopausal disorder improving agent can prevent or improve menopausal disorders.

Figure 1 shows the results of a test example using the menopausal disorder improving agent obtained in the Example.

Figure 2 shows the results of a test example using the menopausal disorder improving agent obtained in the Example.

Figure 3 shows the results of a test example using the menopausal disorder improving agent obtained in the Example.

Figure 4 shows the results of a test example using the menopausal disorder improving agent obtained in the Example.

Hereinafter, embodiments of the present invention will be described in detail. In addition, in this specification, the expressions "including" and "include" include concepts such as "contains", "includes", "substantially constitutes" and "consists only of".

The present invention includes an agent for improving menopausal disorders, which contains Cordyceps sinensis powder or an extract thereof.

The agent for improving menopausal disorders of the present invention contains Cordyceps sinensis as an essential ingredient, or an extract of Cordyceps sinensis as an essential ingredient. The agent for improving menopausal disorders of the present invention may also contain both Cordyceps sinensis and its extract. Menopausal disorder ameliorating agent uses Cordyceps sinensis and its extract as active ingredients.

Cordyceps sinensis is a moth called Cordyceps militaris (P.tenuipes, also known as "Cordyceps sinensis") that parasitizes silkworms. Cordyceps sinensis can be obtained from silkworm pupae as the host.

Cordyceps sinensis can be obtained from commercial products, for example, or it can be cultivated. The method of cultivating Cordyceps sinensis is not particularly limited, and for example, widely known cultivation methods can be used.

A specific method of cultivating Cordyceps sinensis is, for example, a method in which silkworm larvae or silkworm pupae are heat-sterilized and then inoculated with a Cordyceps sinensis strain for cultivation.

Moreover, Cordyceps sinensis can also be cultivated by the method disclosed in Japanese Patent Application Publication No. 2005-237201. The method described in this publication is to boil silkworm larvae or silkworm pupae before they form cocoons, then dry them, and combine the dry powder obtained by this with a mixture of beans, cereals, seaweeds, and mushrooms. At least one dry powder in the group is mixed to prepare a dry food powder. Add the dry food powder to the culture solution and mix it, then lay it on the bottom of the incubator to make a culture medium. After sealing the culture medium in an inoculation bag and performing heat sterilization, the culture medium is inoculated with Cordyceps sinensis strains to cultivate Cordyceps sinensis. In the aforementioned dry food powder, the dry powder of silkworm can be made into 50 to 90% by mass.

When the menopausal disorder improving agent contains Cordyceps sinensis powder, the method of obtaining the powder is not particularly limited, and a known method can be used. For example, Cordyceps sinensis powder can be obtained by freeze-drying and grinding Cordyceps sinensis. Cordyceps sinensis powder can be prepared by using only the fruiting body of Cordyceps militaris, preferably by using the fruiting body and the host (for example, silkworm).

When the menopausal disorder improving agent contains an extract of Cordyceps sinensis, the method for obtaining the extract is not particularly limited, and for example, a known method can be used. Extraction methods of Cordyceps sinensis include, for example, directly cutting, crushing, and/or drying Cordyceps sinensis, and then extracting or extracting it with an appropriate solvent to obtain the extract of Cordyceps sinensis.

烷；乙腈；乙酸乙酯等酯類、以及二甲亞碸、二甲苯、苯、氯仿等。於一實施形態中，較佳溶劑為水、更佳為熱水。熱水可為60℃以上、亦可為70℃以上、亦可為80℃以上、亦可為90℃以上。 The type of solvent used for extraction is not particularly limited, and examples include water, lower alcohols such as methanol, ethanol, and isopropanol; polyols such as propylene glycol and 1,3-butanediol; ketones such as acetone; diethyl ether;

Alkanes; acetonitrile; ethyl acetate and other esters, as well as dimethylsulfoxide, xylene, benzene, chloroform, etc. In one embodiment, the preferred solvent is water, more preferably hot water. The hot water may be 60°C or above, 70°C or above, 80°C or above, or 90°C or above.

The best way to obtain the Cordyceps sinensis extract is to use the above hot water for extraction. The method is to add water or the aforementioned hot water to Cordyceps Sinensis powder, stir it at a temperature of 60°C to 360°C for a predetermined time, such as 1 hour to 5 hours, to prepare an extract, and filter the extract to obtain the filtrate. Drying (for example, spray drying), thereby obtaining the extract of Cordyceps sinensis.

In this extraction method, the dry powder can be obtained by freeze-drying Cordyceps sinensis, for example. The mixing ratio of the dry powder and water or hot water is not particularly limited. For example, 5 to 20 parts by mass, preferably 7 to 15 parts by mass, of water or hot water can be used with respect to 1 part by mass of the dry powder.

When the menopausal disorder improving agent contains an extract of Cordyceps sinensis, the amount of water in the Cordyceps sinensis extract is not particularly limited. For example, it can be 20 mass% or less, preferably 10 mass% or less, more preferably 8 mass% or less. More preferably, it is 5 mass % or less.

The menopausal disorder ameliorating agent may contain any other ingredients in addition to cordyceps sinensis powder or its extract. Types of other ingredients include, for example, various additives contained in known testosterone secretion accelerators, such as excipients, binders, disintegrating agents, lubricants, wetting agents, plasticizers, preservatives, surfactants, Stabilizers, diluents, dissolving agents, isotonic agents, bactericides, preservatives, flavoring agents, deodorants, colorants, spices, etc. The testosterone secretion accelerator may also contain a well-known testosterone secretion accelerator in addition to Cordyceps sinensis powder or its extract.

The content ratio of cordyceps sinensis or its extract contained in the menopausal disorder improving agent is not particularly limited. For example, it can be set to a range of 0.1 mass% or more or 100 mass% or less in terms of solid content. The lower limit of the aforementioned content ratio may be, for example, 1 mass% or more, 2 mass% or more. Quantity % or more, 5 mass % or more, 10 mass % or more, 15 mass % or more, 20 mass % or more, 30 mass % or more, 40 mass % or more, 50 mass % or more, 60 mass % or more or 70 mass % or more, upper limit It may be 99 mass% or less, 95 mass% or less, 90 mass% or less, 80 mass% or less, 70 mass% or less, or 60 mass% or less. These lower and upper limits may be combined in any combination.

The form of the menopausal disorder improving agent of the present invention is not particularly limited, and examples thereof include semi-solid, solid, liquid, and the like. Specific forms include powder, granular, granular, lozenge, capsule, troche, chewable, gel, cream, slurry, mousse, and liquid. Emulsions, suspensions, syrups, etc.

The menopausal disorder ameliorating agent of the present invention is preferably orally ingested, for example, but may be ingested other than this.

The agent for improving menopausal disorders of the present invention can be administered or ingested to humans or animals (other than humans, the same applies below), and can achieve improvement of menopausal disorders, or can achieve prevention of menopausal disorders. Therefore, the menopausal disorder of the present invention The improving agent is preferably used for improving or preventing menopausal disorders. The agent for improving menopausal disorders of the present invention is of course effective not only for women but also for men.

In particular, the menopausal disorder improving agent of the present invention is preferably used for a treatment selected from the group consisting of prevention or improvement of muscle mass loss, prevention or improvement of nerve sensitivity, suppression of anxiety, suppression of depression, prevention or improvement of bone density, At least one of the group consisting of prevention or improvement of depression, prevention or improvement of reduced attention, prevention or improvement of sleep disorders, prevention or improvement of body fat gain, and prevention or improvement of anemia, preferably used for At least one selected from the group consisting of prevention or improvement of muscle mass loss, prevention or improvement of nervous sensitivity, suppression of anxiety, and suppression of depression.

The ingestion (administration) amount of the menopausal disorder improving agent of the present invention is not particularly limited as long as it can exert the intended effect, and may depend on the physique and age of the subject (or subject animal). Set appropriately according to age, symptoms, use form, purpose of use, etc. For example, based on an adult weighing 60 kg, the daily intake (administration) amount of the menopausal disorder improving agent can be set to 1 mg to 8000 mg, 10 mg to 4000 mg, or 100 mg based on the dry weight of Cordyceps sinensis or its extract. to 3000 mg, 500 mg to 2000 mg, etc., for example, it may be a single intake (administration) per day or a plurality of intakes (administration).

The agent for improving menopausal disorders of the present invention can be in the form of a food or drink composition. That is, the present invention also includes a food and drink composition containing a menopausal disorder improving agent. The food and drink composition is preferably used for the improvement or prevention of menopausal disorders. Food and beverages include not only general foods, but also health functional foods (specifically, specific health foods, nutritional functional foods, functional indication foods (foods indicating specific effects)), patient foods, supplementary foods, etc.

The food and drink composition can be preferably used for food in a liquid, gel or solid form, for example. Specific examples include beverages (for example, fruit drinks, vegetable juices, refreshing drinks, alcoholic beverages, carbonated drinks, sports drinks, tonic drinks, health drinks, etc.), snacks (for example, biscuit snacks, rice crackers, chocolate, Gummies, candies, jelly, pudding, Japanese confectionery, Western confectionery, etc.), seasonings (such as soy sauce, miso, mirin-style seasoning, mixed spices, dipping sauce, Japanese soy sauce, sauces, ketchup, etc.) , salad dressing (dressing), noodles (such as udon, soba, pasta, etc.), processed meat and fish foods (such as sausages, Vienna sausages, ham, burgers, etc.), dairy products (yoghurt, Milk, cheese, fresh cream, cream, etc.) and other foods.

The agent for improving menopausal disorders of the present invention can be in the form of a nutritional supplement. That is, the present invention also includes nutritional supplements containing a menopausal disorder improving agent. The nutritional supplementary food is preferably used for the improvement or prevention of menopausal disorders. Nutritional supplements can be used, for example, in supplementary foods, and preferably can be used in so-called prescription supplement foods (doctors supplement foods).

The menopausal disorder improving agent of the present invention can be in the form of a food additive. That is, the present invention also includes food additives containing a menopausal disorder improving agent. The best food additive Used for the improvement or prevention of menopausal disorders. Examples of foods as food additives include the same types of foods as those in the aforementioned food and drink compositions.

The menopausal disorder ameliorating agent of the present invention can be used in the form of medicines, cosmetics, feed, etc., in addition to the above-mentioned food uses (health food includes health promoters), nutritional supplements, and food additives.

When the menopausal disorder ameliorating agent of the present invention is in the form of a pharmaceutical (for example, a pharmaceutical composition), a pharmaceutically acceptable excipient may be combined with the powder or extract of Cordyceps sinensis.

The present invention also includes the use of Cordyceps sinensis powder or its extract. That is, the present invention includes the use of powder or extract of Cordyceps sinensis for producing the aforementioned menopausal disorder ameliorating agent.

Furthermore, the present invention also includes a method of administering Cordyceps sinensis powder or extract. That is, the present invention also includes a method of administering Cordyceps sinensis powder or extract to a subject who needs to improve or prevent menopausal disorders. The Cordyceps sinensis powder or extract in this method is the same as the Cordyceps sinensis powder or extract contained in the menopausal disorder improving agent of the present invention. The object that needs to improve or prevent menopausal disorders is humans or animals other than humans.

Furthermore, the present invention also includes Cordyceps sinensis powder or extract for use in improving or preventing menopausal disorders. The Cordyceps sinensis powder or extract is the same as the Cordyceps sinensis powder or extract contained in the menopausal disorder ameliorating agent of the present invention.

In order to specify the invention included in the present disclosure, the respective components (properties, structures, and functions) described in each embodiment of the present disclosure may be combined in any manner. That is, the present disclosure includes the subject matter formed by all combinations of the combinable components described in this specification.

[Example]

Hereinafter, the present invention will be explained in more detail through examples, but the present invention is not limited to the aspects of these examples.

(Example 1)

Cordyceps sinensis (Cordyceps sinensis) obtained using silkworm pupae as a host is freeze-dried and crushed with a mixer to obtain Cordyceps sinensis powder. 200 mg of the obtained Cordyceps sinensis powder was filled into a hard capsule to prepare a sample of a menopausal disorder improving agent.

(Test example)

Twenty subjects (14 males and 6 females) selected through screening were allowed to ingest the sample obtained in Example 1 twice a day for four weeks. Each intake is 4 capsules (the daily intake of Cordyceps sinensis powder is 1600mg). Before ingestion, two weeks after ingestion, and four weeks after ingestion, the following questionnaire survey was conducted on each subject. Each question was scored in the questionnaire: "None 1 point; Mild 2 points; Moderate 3 points; Severe 4 points "Extremely severe 5 points", and the effect of improving menopausal disorders was evaluated based on the results of the questionnaire.

<Questionnaire>

Q1: I have conscious symptoms of poor physical and mental health.

Q2: Have joint pain or muscle pain. There are low back pain, muscle pain, pain in hands and feet, and overall back pain.

Q3: Sweating often. Sudden sweating when not paying attention. Not nervous but warm.

Q4: Have sleep disorder. Didn't sleep well. Wake up often. Woke up very early and felt tired. Not enough sleep, unable to sleep.

Q5: I need sleep very much and often feel tired.

Q6: Irritable and anxious. Often get angry over trivial things. Not happy.

Q7: Nerve sensitivity. Feel nervous. I often feel irritable and restless.

Q8: Anxiety disorder, worry, and easy panic.

Q9: Physical fatigue, lack of energy, decreased overall ability, decreased activity, and decreased interest in leisure activities. Listless, without a sense of accomplishment, unable to achieve what you want to do without forcing yourself.

Q10: Muscle strength gradually decreases. Feeling weak.

Q11: Feeling depressed makes you easily depressed. sad. I feel like I'm about to cry. Unmotivated and helpless. The mood swings violently.

Q12: Feeling "burned out" and "at the lowest point".

In the above questionnaire, Q6 is an indicator of anxiety, Q7 is an indicator of nervous sensitivity, Q10 is an indicator of decreased muscle mass, and Q11 is an indicator of depression.

Figures 1 to 4 show the questionnaires of 20 subjects (marked with 1 to 20 on the horizontal axis) for Q6 (anxiety), Q7 (nerve sensitivity), Q10 (decreased muscle mass), and Q11 (depression) respectively. The score of the result (vertical axis). In addition, in the graphs of Figures 1 to 4, the three bars on the horizontal axis for each of subjects 1 to 20 show, from the left, the results of the questionnaire before ingestion, two weeks after the start of ingestion, and four weeks after the start of ingestion. score.

From the results in Figures 1 to 4, at least 5 out of 20 subjects showed a tendency to improve. It can be seen that the intake of menopausal disorder improving agents can improve muscle mass loss, improve nervousness, suppress anxiety, and suppress depression. .

Claims (5)

An agent for improving menopausal disorders, which contains powder or extract of Cordyceps sinensis. The menopausal disorder improving agent according to Claim 1, which is used in a group selected from the group consisting of preventing or improving muscle mass loss, preventing or improving nervousness, suppressing anxiety, and suppressing depression. At least one of them. The agent for improving menopausal disorders according to claim 1 or 2, which is in the form of a food or drink composition. The agent for improving menopausal disorders according to claim 1 or 2, which is in the form of a nutritional supplement food composition. The agent for improving menopausal disorders as described in claim 1 or 2, which is in the form of a food additive.

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