TW202346586A - 用於抑制前激肽釋放酶(pkk)蛋白表達的組合物和方法 - Google Patents

用於抑制前激肽釋放酶(pkk)蛋白表達的組合物和方法 Download PDF

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TW202346586A
TW202346586A TW112102528A TW112102528A TW202346586A TW 202346586 A TW202346586 A TW 202346586A TW 112102528 A TW112102528 A TW 112102528A TW 112102528 A TW112102528 A TW 112102528A TW 202346586 A TW202346586 A TW 202346586A
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pkk
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dsrna
nucleotides
dsrna agent
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TW112102528A
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Chinese (zh)
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舒東旭
鵬程 邵
夏時偉
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大陸商上海舶望製藥有限公司
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    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12Y304/21Serine endopeptidases (3.4.21)
    • C12Y304/21035Tissue kallikrein (3.4.21.35)
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/713Double-stranded nucleic acids or oligonucleotides
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    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21Serine endopeptidases (3.4.21)
    • C12Y304/21008Kallikrein (3.4.21.8)
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    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21Serine endopeptidases (3.4.21)
    • C12Y304/21034Plasma kallikrein (3.4.21.34)
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    • C12N2310/00Structure or type of the nucleic acid
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
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    • C12N2320/30Special therapeutic applications
    • C12N2320/32Special delivery means, e.g. tissue-specific

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  • Life Sciences & Earth Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
TW112102528A 2022-01-28 2023-01-19 用於抑制前激肽釋放酶(pkk)蛋白表達的組合物和方法 TW202346586A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
WOPCT/CN2022/074535 2022-01-28
CN2022074535 2022-01-28

Publications (1)

Publication Number Publication Date
TW202346586A true TW202346586A (zh) 2023-12-01

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ID=87470605

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Application Number Title Priority Date Filing Date
TW112102528A TW202346586A (zh) 2022-01-28 2023-01-19 用於抑制前激肽釋放酶(pkk)蛋白表達的組合物和方法

Country Status (11)

Country Link
US (1) US20250145999A1 (https=)
EP (1) EP4469570A1 (https=)
JP (1) JP2025508324A (https=)
KR (1) KR20240139057A (https=)
CN (1) CN118510894A (https=)
AU (1) AU2023210979A1 (https=)
CA (1) CA3244243A1 (https=)
IL (1) IL314396A (https=)
MX (1) MX2024009257A (https=)
TW (1) TW202346586A (https=)
WO (1) WO2023143483A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12042509B2 (en) * 2021-10-01 2024-07-23 Adarx Pharmaceuticals, Inc. Prekallikrein-modulating compositions and methods of use thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102365486B1 (ko) * 2013-08-28 2022-02-18 아이오니스 파마수티컬즈, 인코포레이티드 프리칼리크레인 (pkk) 발현의 조절
HUE052709T2 (hu) * 2014-05-01 2021-05-28 Ionis Pharmaceuticals Inc Módosított antiszensz oligonukleotidok konjugátumai és azok alkalmazása PKK expressziójának módosítására
JP6695902B2 (ja) * 2015-05-06 2020-05-20 アルナイラム ファーマシューティカルズ, インコーポレイテッドAlnylam Pharmaceuticals, Inc. 第XII因子(ハーゲマン因子)(F12)、カリクレインB、血漿(フレッチャー因子)1(KLKB1)、及びキニノーゲン1(KNG1)iRNA組成物及びその使用方法
CN109762904A (zh) * 2019-03-05 2019-05-17 中国医学科学院北京协和医院 与胰腺神经内分泌肿瘤相关的分子标记物及其应用
US20220315929A1 (en) * 2019-05-24 2022-10-06 Suzhou Ribo Life Science Co., Ltd. Nucleic acid, pharmaceutical composition and conjugate, preparation method therefor and use thereof
WO2021126734A1 (en) * 2019-12-16 2021-06-24 Alnylam Pharmaceuticals, Inc. Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof
BR112022015380A2 (pt) * 2020-02-07 2022-09-27 Intellia Therapeutics Inc Composições e métodos para edição de gene de calicreína (klkb1)

Also Published As

Publication number Publication date
CA3244243A1 (en) 2023-08-03
IL314396A (en) 2024-09-01
KR20240139057A (ko) 2024-09-20
MX2024009257A (es) 2024-08-06
CN118510894A (zh) 2024-08-16
US20250145999A1 (en) 2025-05-08
JP2025508324A (ja) 2025-03-26
EP4469570A1 (en) 2024-12-04
WO2023143483A1 (en) 2023-08-03
AU2023210979A1 (en) 2024-08-01

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