TW202342011A - 用於治療睡眠呼吸中止之α2-腎上腺素受體亞型C(α-2C)拮抗劑與蕈毒鹼受體拮抗劑之組合 - Google Patents
用於治療睡眠呼吸中止之α2-腎上腺素受體亞型C(α-2C)拮抗劑與蕈毒鹼受體拮抗劑之組合 Download PDFInfo
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- TW202342011A TW202342011A TW111148913A TW111148913A TW202342011A TW 202342011 A TW202342011 A TW 202342011A TW 111148913 A TW111148913 A TW 111148913A TW 111148913 A TW111148913 A TW 111148913A TW 202342011 A TW202342011 A TW 202342011A
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- Prior art keywords
- methyl
- thiazole
- difluoropyridin
- bipiperidin
- methamide
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
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- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP21216889 | 2021-12-22 | ||
| EP21216889.2 | 2021-12-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW202342011A true TW202342011A (zh) | 2023-11-01 |
Family
ID=79021054
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW111148913A TW202342011A (zh) | 2021-12-22 | 2022-12-20 | 用於治療睡眠呼吸中止之α2-腎上腺素受體亞型C(α-2C)拮抗劑與蕈毒鹼受體拮抗劑之組合 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20250057828A1 (https=) |
| EP (1) | EP4452245A1 (https=) |
| JP (1) | JP2025500346A (https=) |
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| US3966781A (en) | 1970-12-17 | 1976-06-29 | Merck Sharp & Dohme (I.A.) Corporation | Deuteration of functional group-containing hydrocarbons |
| HRP20041026A2 (en) | 2002-04-03 | 2005-06-30 | Orion Corporation | Polycyclic compounds as potent alpha2-adrenoceptor antagonists |
| US8791162B2 (en) | 2011-02-14 | 2014-07-29 | Merck Sharp & Dohme Corp. | Cathepsin cysteine protease inhibitors |
| WO2017031319A1 (en) | 2015-08-18 | 2017-02-23 | Massachusetts Institute Of Technology | Noradrenergic drug treatment of obstructive sleep apnea |
| GEAP202416602A (en) | 2017-04-28 | 2024-10-10 | Brigham & Womens Hospital Inc | Methods and compositions for treating sleep apnea |
| KR102874891B1 (ko) | 2018-01-30 | 2025-10-21 | 애프니메드, 인코포레이티드 (델라웨어) | 수면 무호흡증을 치료하기 위한 방법 및 조성물 |
| US20210338662A1 (en) * | 2018-09-25 | 2021-11-04 | Bayer Aktiengeselischaft | Alpha-2-adrenoceptor subtype c (alpha-2c) antagonists for the treatment of sleep apnea |
| CA3139298A1 (en) | 2019-05-09 | 2020-11-12 | Bayer Aktiengesellschaft | Combination of an a2-adrenoceptor subtype c (alpha-2c) antagonists with a task1/3 channel blocker for the treatment of sleep apnea |
| TW202108139A (zh) | 2019-05-09 | 2021-03-01 | 德商拜耳廠股份有限公司 | 用於治療睡眠呼吸中止之α2—腎上腺素受體亞型C(α—2C)拮抗劑與TASK1/3通道阻斷劑之組合 |
| EP3965763A1 (en) * | 2019-05-09 | 2022-03-16 | Bayer Aktiengesellschaft | Arylquinoziline derivatives as alpha2-adrenoceptor subtype c (alpha-2c) antagonists for the treatment of sleep apnea |
| PE20221025A1 (es) | 2019-11-06 | 2022-06-16 | Bayer Ag | Inhibidores de los receptores a2c adrenergicos |
| WO2022008426A1 (en) * | 2020-07-06 | 2022-01-13 | Bayer Aktiengesellschaft | Combination of an alpha2-adrenoceptor subtype c (alpha-2c) antagonist with a task1/3 channel blocker for the treatment of sleep apnea |
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| CA3259602A1 (en) | 2023-06-29 |
| CN118434414A (zh) | 2024-08-02 |
| WO2023118098A1 (en) | 2023-06-29 |
| IL313654A (en) | 2024-08-01 |
| AU2022422053A1 (en) | 2024-07-11 |
| US20250057828A1 (en) | 2025-02-20 |
| EP4452245A1 (en) | 2024-10-30 |
| JP2025500346A (ja) | 2025-01-09 |
| MX2024007767A (es) | 2024-07-04 |
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