TW202339696A - System of using multi-mode rhythmic movement to improve blood circulation can perform horizontal rhythmic movement with different frequencies in segments to maximize the effect on the user's health - Google Patents
System of using multi-mode rhythmic movement to improve blood circulation can perform horizontal rhythmic movement with different frequencies in segments to maximize the effect on the user's health Download PDFInfo
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Abstract
Description
本發明是有關於一種水平律動系統,特別是指一種能以多重模式對使用者進行全身週期性加速運動並刺激血管內皮細胞產生內皮一氧化氮合酶的運用多重模式律動改善血液循環系統。The present invention relates to a horizontal rhythm system, in particular to a multi-mode rhythm-improving blood circulation system that can perform periodic acceleration of the user's whole body in multiple modes and stimulate vascular endothelial cells to produce endothelial nitric oxide synthase.
運動一直以來被視為對改善身體健康的重要手段,透過運動,可以促進心血管的血液循環,並通過刺激血管內皮細胞 (Endothelial Cell, EC)產生內皮一氧化氮合酶 (Endothelial Nitric Oxide Synthase, eNOS) 來誘導增強一氧化氮 (NO) 的合成。但在現代社會的忙碌生活型態中,有許多不利於運動的因素例如缺乏時間,或是因年齡增長而來的失能、衰老、慢性病等症狀使人不方便進行運動,也就造成部分人健康持續惡化的惡性循環。Exercise has always been regarded as an important means to improve physical health. Through exercise, it can promote cardiovascular blood circulation and stimulate endothelial cells (Endothelial Cells, EC) to produce endothelial nitric oxide synthase (Endothelial Nitric Oxide Synthase). eNOS) to induce enhanced nitric oxide (NO) synthesis. However, in the busy lifestyle of modern society, there are many factors that are not conducive to exercise, such as lack of time, or symptoms such as disability, aging, and chronic diseases due to age, which make it inconvenient for people to exercise, which also causes some people to A vicious cycle of continued deterioration in health.
而除了主動運動以外,尚有被動運動模式,例如全身週期性加速度(Whole Body Periodic Acceleration, WBPA),WBPA可作為無法運動的替代方法,它以外力將躺臥的使用者進行水平律動,讓某種程度的剪應力傳送到使用者的全身血管,促進血管中內皮型一氧化氮合酶(eNOS)的生產,可改善使用者的血管健康。若能善加利用,便能造福許多不方便進行運動的人。In addition to active movement, there are also passive movement modes, such as Whole Body Periodic Acceleration (WBPA). WBPA can be used as an alternative to immobility. It uses an external force to move a lying user horizontally, allowing someone to move. This degree of shear stress is transmitted to the user's systemic blood vessels, promoting the production of endothelial nitric oxide synthase (eNOS) in the blood vessels, which can improve the user's vascular health. If used properly, it can benefit many people who are inconvenient to exercise.
有鑑於此,本發明人乃潛心研思、設計組製,期能提供一種組合不同頻率的水平律動系統,即為本發明所欲研創之發明動機者。In view of this, the inventor has devoted himself to research and design, hoping to provide a horizontal rhythm system that combines different frequencies, which is the motivation behind the invention.
本發明之主要目的,即在提供一種運用多重模式律動改善血液循環系統,分段進行不同頻率的水平律動,以對使用者的健康產生最大功效。The main purpose of the present invention is to provide a system that uses multiple modes of rhythm to improve the blood circulation system, and performs horizontal rhythms of different frequencies in segments to produce the maximum effect on the user's health.
本發明之運用多重模式律動改善血液循環系統,其特徵在於使用一多重模式水平律動,多重模式水平律動包含一加速段,加速段中水平律動之頻率用第一時間上升到第一頻率;一持續段,持續段具有至少一律動循環,在律動循環中具多個子持續段,多個子持續段中的第一個的水平律動之頻率大於第一頻率,多個子持續段中的第一個至倒數第二個的水平律動之頻率依序遞增,最後一個子持續段的水平律動之頻率小於第一頻律;及一減速段,減速段具多個子減速段,多個子減速段中的第一個的水平律動之頻率小於第一頻率,多個子減速段中的第一個至最後一個的水平律動之頻率依序遞減。The present invention uses multi-mode rhythm to improve the blood circulation system, which is characterized by using a multi-mode horizontal rhythm. The multi-mode horizontal rhythm includes an acceleration section, and the frequency of the horizontal rhythm in the acceleration section rises to the first frequency in the first time; The sustained segment has at least one rhythm cycle, and has multiple sub-sustained segments in the rhythm cycle. The frequency of the horizontal rhythm of the first of the multiple sub-sustained segments is greater than the first frequency, and the first of the multiple sub-sustained segments is The frequency of the penultimate horizontal rhythm increases sequentially, and the frequency of the horizontal rhythm of the last sub-sustained segment is less than the first frequency; and a deceleration segment, the deceleration segment has multiple sub-deceleration segments, the first of the multiple sub-deceleration segments The frequency of the horizontal rhythm of each is less than the first frequency, and the frequency of the horizontal rhythm from the first to the last of the plurality of sub-deceleration sections decreases in sequence.
在一較佳的實施例中,加速段中第一時間為5分鐘,第一頻率為140每分鐘次數(RPM);持續段中有四個子持續段,第一子持續段頻率為150每分鐘次數,第二子持續段頻率為165每分鐘次數,第三子持續段頻率為180每分鐘次數,第四子持續段頻率為120每分鐘次數,第一子持續段為一分鐘,第二子持續段為一分鐘,第三子持續段為3分鐘,上述為一律動循環重複進行到共30分鐘;減速段中有三個子減速段,第一個子減速段為100每分鐘次數持續一分鐘,第二個子減速段為90每分鐘次數持續一分鐘,第三個子減速段為70每分鐘次數持續五分鐘後結束。水平律動的震幅可為1.0~2.5公分,例如2公分。In a preferred embodiment, the first time in the acceleration segment is 5 minutes, and the first frequency is 140 times per minute (RPM); there are four sub-sustaining segments in the sustaining segment, and the frequency of the first sub-sustaining segment is 150 times per minute. times, the frequency of the second sub-sustaining segment is 165 times per minute, the frequency of the third sub-sustaining segment is 180 times per minute, the frequency of the fourth sub-sustaining segment is 120 times per minute, the first sub-sustaining segment is one minute, the second sub-sustaining segment is The duration section is one minute, and the third sub-sustaining section is 3 minutes. The above is a rhythmic cycle repeated for a total of 30 minutes. There are three sub-deceleration sections in the deceleration section. The first sub-deceleration section is 100 times per minute and lasts for one minute. The second sub-deceleration segment is 90 times per minute and lasts for one minute, and the third sub-deceleration segment is 70 times per minute and ends after five minutes. The amplitude of the horizontal rhythm can be 1.0~2.5 cm, such as 2 cm.
WBPA是一種新型的非侵入性的運動平台,使用者仰躺床上,以脊椎為軸心,反覆進行由頭到腳、再由腳到頭的前後水平運動,對全身提供被動運動及血管內皮細胞的搏動製造剪應力,剪應力是一種可以影響血流動力學的力量,經由調整內皮細胞基因表型和功能來促進內皮型一氧化氮合酶(eNOS)的生產。層流剪力已證明能減少氧化性應力和振盪剪力推測會誘導氧化性應力。週期加速已實際地增加血漿亞硝酸鹽和前列腺素的量。且WBPA有下列好處:1、WBPA可提供中風患者另一種被動的鍛煉方法。2、WBPA可改善糖尿患者的動脈血流量。3、WBPA可以改善終末期腎病患者心肺功能。4、WBPA可能提供便秘者改善排便模式的替代科學方法。5、WBPA可能提供下肢動脈阻塞的替代運動方法。WBPA is a new type of non-invasive exercise platform. The user lies on his back on the bed, with the spine as the axis, and repeatedly performs forward and backward horizontal movements from head to toes, and then from feet to head, providing passive movement and vascular endothelial cells to the whole body. The pulsation creates shear stress, a force that can affect hemodynamics and promote the production of endothelial nitric oxide synthase (eNOS) by adjusting endothelial cell gene phenotype and function. Laminar shear has been shown to reduce oxidative stress and oscillatory shear is hypothesized to induce oxidative stress. Cycle acceleration has actually increased plasma nitrite and prostaglandin amounts. And WBPA has the following benefits: 1. WBPA can provide another passive exercise method for stroke patients. 2. WBPA can improve arterial blood flow in patients with diabetes. 3. WBPA can improve the cardiopulmonary function of patients with end-stage renal disease. 4. WBPA may provide an alternative scientific method for constipation patients to improve their bowel movements. 5. WBPA may provide an alternative exercise method for lower extremity arterial obstruction.
本發明之實施裝置可包括有一底座、一床架及一驅動單元,床架滑設於底座之上,驅動單元設於底座並驅動床架進行水平律動。除了完全水平律動之外,本發明的律動模式亦可使用於以正反方向進行擺動的鐘擺式軌跡與橢圓型軌跡進行的類水平律動(也就是鐘擺式軌跡律動與橢圓型軌跡律動)。The implementation device of the present invention may include a base, a bed frame and a driving unit. The bed frame is slidably mounted on the base. The driving unit is located on the base and drives the bed frame to perform horizontal movement. In addition to completely horizontal rhythm, the rhythm mode of the present invention can also be used for quasi-horizontal rhythms (that is, pendulum path rhythm and elliptical path rhythm) that swing in forward and reverse directions.
在另一實施例中,本發明進一步包含一用以即時偵測使用者每分鐘心跳數的心律感知單元,並以使用者之即時每分鐘心跳數的2倍做為水平律動之頻率的上限,以使用者之即時每分鐘心跳數的1.6倍作為水平律動之頻率的下限。In another embodiment, the present invention further includes a heart rhythm sensing unit for real-time detection of the user's heartbeat per minute, and uses 2 times the user's real-time heartbeat per minute as the upper limit of the frequency of the horizontal rhythm. The lower limit of the horizontal rhythm frequency is 1.6 times the user's real-time heart rate per minute.
為了能夠更進一步瞭解本發明之特徵、特點和技術內容,請參閱以下有關本發明之詳細說明。In order to further understand the features, characteristics and technical content of the present invention, please refer to the following detailed description of the present invention.
請參閱第一圖至第五圖,揭示本發明實施方式的圖例中,由上述圖式說明本發明之運用多重模式律動改善血液循環系統,其特徵在於使用一多重模式水平律動,多重模式水平律動包含一加速段1,加速段1中水平律動之頻率用第一時間T1上升到第一頻率F1;一持續段2,持續段2具有至少一律動循環,在律動循環中具多個子持續段,多個子持續段中的第一個的水平律動之頻率大於第一頻率F1,多個子持續段中的第一個至倒數第二個的水平律動之頻率依序遞增,最後一個子持續段的水平律動之頻率小於第一頻律;及一減速段,減速段具多個子減速段3A,多個子減速段3A中的第一個的水平律動之頻率小於第一頻率F1,多個子減速段3A中的第一個至最後一個的水平律動之頻率依序遞減。本發明之各子持續段分別有一持續時間,多個子持續段中的倒數第二個的持續時間可大於等於其餘子持續段的持續時間。Please refer to Figures 1 to 5, which illustrate the embodiments of the present invention. The above figures illustrate the use of multi-mode rhythm to improve the blood circulation system of the present invention, which is characterized by using a multi-mode horizontal rhythm. The rhythm includes an
本發明可對使用者進行WBPA,對血管施加剪應力以刺激內皮細胞產生內皮一氧化氮合酶。WBPA是一種新型的非侵入性的運動平台,對全身提供被動運動及血管內皮細胞的搏動製造剪力,剪應力是一種可以影響血流動力學的力量,經由調整內皮細胞基因表型和功能來促進內皮型一氧化氮合酶(eNOS)的生產。層流剪力已證明能減少氧化性應力和振盪剪力推測會誘導氧化性應力。週期加速已實際地增加血漿亞硝酸鹽和前列腺素的量。且WBPA有下列好處:1、WBPA可提供中風患者另一種被動的鍛煉方法。2、WBPA可改善糖尿患者的動脈血流量。3、WBPA可以改善終末期腎病患者心肺功能。4、WBPA可能提供便秘者改善排便模式的替代科學方法。5、WBPA可能提供下肢動脈阻塞的替代運動方法。The present invention can perform WBPA on the user, applying shear stress to blood vessels to stimulate endothelial cells to produce endothelial nitric oxide synthase. WBPA is a new type of non-invasive exercise platform that provides passive movement to the whole body and the pulsation of vascular endothelial cells to create shear stress. Shear stress is a force that can affect hemodynamics by adjusting the gene phenotype and function of endothelial cells. Promotes the production of endothelial nitric oxide synthase (eNOS). Laminar shear has been shown to reduce oxidative stress and oscillatory shear is hypothesized to induce oxidative stress. Cycle acceleration has actually increased plasma nitrite and prostaglandin amounts. And WBPA has the following benefits: 1. WBPA can provide another passive exercise method for stroke patients. 2. WBPA can improve arterial blood flow in patients with diabetes. 3. WBPA can improve the cardiopulmonary function of patients with end-stage renal disease. 4. WBPA may provide an alternative scientific method for constipation patients to improve their bowel movements. 5. WBPA may provide an alternative exercise method for lower extremity arterial obstruction.
第二圖中可以看到本發明之實施裝置可包括有一底座A、一床架B及一驅動單元(未繪製),床架B滑設於底座A之上,驅動單元(未繪製)設於底座A並驅動床架B進行水平律動。As can be seen in the second figure, the implementation device of the present invention may include a base A, a bed frame B and a driving unit (not shown). The bed frame B is slidably installed on the base A, and the driving unit (not shown) is installed on the base A. Base A and drives bed frame B to perform horizontal movement.
習知的水平律動是指躺在床上,以脊椎為軸心進行前後距離超過一公分以上,從頭端至腳端重複做往返重複的律動。而本發明採用間歇式脈衝頻率的設計,是以間歇式主動運動快速、慢速兩者交替的方式,來進行被動式的水平律動。除了完全水平律動之外,本發明的律動模式亦可使用於以正反方向進行擺動的鐘擺式軌跡與橢圓型軌跡進行的類水平律動(也就是鐘擺式軌跡律動與橢圓型軌跡律動)。The commonly known horizontal rhythm refers to lying on the bed, using the spine as the axis, moving back and forth more than one centimeter, and repeating the rhythm back and forth from the head to the toes. The present invention uses an intermittent pulse frequency design to perform passive horizontal rhythm by alternating between fast and slow intermittent active movements. In addition to completely horizontal rhythm, the rhythm mode of the present invention can also be used for quasi-horizontal rhythms (that is, pendulum path rhythm and elliptical path rhythm) that swing in forward and reverse directions.
第三圖中,可以看到本實施例中加速段1中第一時間T1為3分鐘,第一頻率F1為140每分鐘次數(RPM),本實施例中水平律動之頻率以線性上升。In the third figure, it can be seen that the first time T1 in the
第四圖中,可以看到持續段2中律動循環共有四個子持續段,第一個子持續段的第一持續頻率F2為150每分鐘次數,第一持續時間T2為一分鐘,第二個子持續段的第二持續頻率F3為165每分鐘次數,第二持續時間T3為一分鐘,第三個子持續段的第三持續頻率F4為180每分鐘次數,第三持續時間T4為三分鐘,第四個子持續段的第四持續頻率F5為120每分鐘次數,第四持續時間T5為三分鐘,上述為一律動循環,本實施例中律動循環重複三次後,在第四次(最後一次律動循環)的第四持續頻率F5進行一分鐘的第五持續時間T6後就切換至減速段3,故本實施例中持續段共30分鐘;另一實施例在律動循環重複四次後,在第五次的第四持續頻率F5進行一分鐘的第五持續時間T6後切換至減速段3,此時持續段共38分鐘。In the fourth picture, you can see that there are four sub-sustained segments in the rhythm cycle in sustain
第五圖中,可以看到減速段3中第一個子減速段為100每分鐘次數持續一分鐘,第二個子減速段為90每分鐘次數持續一分鐘,第三個子減速段為70每分鐘次數持續五分鐘後結束,故本實施例共有三個子減速段3A。水平律動的震幅可為1.0~2.5公分,例如2公分。In the fifth picture, you can see that the first sub-deceleration section in
本發明藉由和緩加速的加速段1讓使用者適應水平律動,再由持續段2循環施加最能刺激內皮型一氧化氮合酶產生的頻率(大於150RPM)並搭配較和緩的水平律動(120RPM),讓使用者不會長時間承受高強度的水平律動,減少使用者產生不適感的機率;減速段3讓水平律動之頻率以三個子減速段由100、90RPM各持續一分鐘後再降到70RPM,然後在70RPM持續5分鐘,以較低強度的水平律動讓使用者的身體進行舒緩。The invention allows users to adapt to the horizontal rhythm through the gently accelerating
第六圖中為高雄醫學大學醫學博士,陳嘉炘博士所進行的實驗,其對人臍靜脈內皮細胞(Human Umbilical Vein Endothelial Cell, HUVEC)進行不同頻率(0、60、90、120、150RPM)的20分鐘WBPA水平律動以觀測介質中的亞硝酸鹽含量之變化(第三圖a)及內皮型一氧化氮合酶的mRNA量之變化(第三圖b),其中WBPA之震幅固定為2公分;第三圖(a)中縱軸為亞硝酸鹽(Nitrite)之濃度,亞硝酸鹽濃度越高,代表eNOS的量可能越多(亞硝酸鹽並非一定來自於eNOS所產生);第三圖(b)中縱軸為eNOS之mRNA與控制組甘油醛-3-磷酸脫氫酶(GAPDH)之mRNA之間的比例,eNOS之mRNA比例越高,就代表eNOS的量越多。第三圖(a)、(b)中最右側的SNP數據為硝普鈉水合物(Sodium nitroprusside dihydrate)的量測結果,作為控制組數據。可以看到WBPA的頻率在133~150RPM之間,特別是150RPM上下時可以達到最高的內皮型一氧化氮合酶(eNOS)產生量,也就是最能刺激HUVEC產生內皮型一氧化氮合酶的頻率。故本發明採用大於150每分鐘次數的頻率來達到最佳效益。The sixth picture shows an experiment conducted by Dr. Chen Jiaxin, MD of Kaohsiung Medical University. He performed 20 different frequencies (0, 60, 90, 120, 150RPM) on human umbilical vein endothelial cells (HUVEC). Minutes of WBPA level rhythm to observe changes in nitrite content in the medium (Figure 3a) and changes in the amount of endothelial nitric oxide synthase mRNA (Figure 3b), where the amplitude of WBPA is fixed at 2 cm ; The vertical axis in the third figure (a) is the concentration of nitrite. The higher the nitrite concentration, the greater the amount of eNOS (nitrite does not necessarily come from eNOS); the third figure (b) The vertical axis in (b) is the ratio between the mRNA of eNOS and the mRNA of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in the control group. The higher the ratio of eNOS mRNA, the greater the amount of eNOS. The rightmost SNP data in the third figure (a) and (b) is the measurement result of sodium nitroprusside dihydrate, which serves as the control group data. It can be seen that the frequency of WBPA is between 133 and 150RPM. Especially around 150RPM, the highest endothelial nitric oxide synthase (eNOS) production can be achieved, which is the frequency that can best stimulate HUVEC to produce endothelial nitric oxide synthase. frequency. Therefore, the present invention uses a frequency greater than 150 times per minute to achieve optimal benefits.
人體的組織五臟六腑之所以老化,大多是因為微血管受到廢棄物的阻塞,當阻塞越多的時候,身體的組織器官也就老化了。水平律動本身就會產生一氧化氮合成酶,跟血管內皮裡面的精氨酸結合以後在血液中釋放出一氧化氮,有助於血管放鬆以及血管的擴張,能夠讓血液的流量增加。水平脈動的實施方式,以水平律動的最高效益每分鐘次數大於150,實施間歇式的水平律動,其間歇式的頻率,能夠在血管中形成不同的血液脈動;結合律動時釋放出的一氧化氮讓血管擴張的功能,讓原本阻塞的微血管,在受到不同大小的血液衝擊狀況下,重新恢復暢通。The reason why the human body's tissues and organs age is mostly because the capillaries are blocked by waste. When there are more blockages, the body's tissues and organs also age. Horizontal rhythm itself produces nitric oxide synthase, which combines with arginine in the vascular endothelium to release nitric oxide in the blood, which helps blood vessels relax and dilate, and can increase blood flow. The implementation method of horizontal pulsation is to implement intermittent horizontal rhythm with the highest benefit of horizontal rhythm being more than 150 times per minute. Its intermittent frequency can form different blood pulsations in blood vessels; combined with the nitric oxide released during the rhythm The function of dilating blood vessels allows the originally blocked capillaries to become unblocked again under the impact of different sizes of blood.
在本發明之另一實施例中,本發明進一步包含一用以即時偵測使用者每分鐘心跳數的心律感知單元(未繪製),並以使用者之即時每分鐘心跳數的2倍做為水平律動之頻率(每分鐘次數)的上限,以使用者之即時每分鐘心跳數的1.6倍作為水平律動之頻率(每分鐘次數)的下限,在此範圍內進行即時調整、變頻式的律動。例如持續段2中各子持續段之水平律動頻率皆小於使用者之即時心跳數的2倍,減速段3中各子減速段3A之水平律動頻率皆大於使用者之即時心跳數的1.6倍。In another embodiment of the present invention, the present invention further includes a heart rhythm sensing unit (not shown) for real-time detection of the user's heartbeat per minute, and uses 2 times the user's real-time heartbeat per minute as The upper limit of the frequency of horizontal rhythm (number of times per minute) is 1.6 times the user's real-time heartbeat per minute as the lower limit of the frequency of horizontal rhythm (number of times per minute). Real-time adjustment and variable frequency rhythm are performed within this range. For example, the horizontal rhythm frequency of each sub-segment in
惟以上所述者,僅為本發明之較佳實施例,當不能用以限定本發明可實施之範圍,凡習於本業之人士所明顯可作的變化與修飾,皆應視為不悖離本發明之實質內容。However, the above are only preferred embodiments of the present invention and cannot be used to limit the scope of the present invention. All changes and modifications that are obvious to those skilled in the art should be deemed not to depart from the scope of the present invention. The essence of the present invention.
1:加速段 2:持續段 3:減速段 3A:子減速段 A:底座 B:床架 F1:第一頻率 F2:第一持續頻率 F3:第二持續頻率 F4:第三持續頻率 F5:第四持續頻率 T1:第一時間 T2:第一持續時間 T3:第二持續時間 T4:第三持續時間 T5:第四持續時間 T6:第五持續時間 1: Acceleration section 2: Sustained segment 3:Deceleration section 3A: Sub-deceleration section A:Base B: Bed frame F1: first frequency F2: First sustained frequency F3: Second continuous frequency F4: The third continuous frequency F5: The fourth continuous frequency T1: the first time T2: first duration T3: Second duration T4: Third duration T5: fourth duration T6: fifth duration
第一圖為本發明之實施例(一)之流程圖。 第二圖為本發明之實施例(一)之示意圖。 第三圖為本發明之實施例(一)之加速段之頻率變化示意圖。 第四圖為本發明之實施例(一)之持續段之頻率變化示意圖。 第五圖為本發明之實施例(一)之減速段之頻率變化示意圖。 第六圖為水平律動之實驗功效示意圖。 The first figure is a flow chart of Embodiment (1) of the present invention. The second figure is a schematic diagram of Embodiment (1) of the present invention. The third figure is a schematic diagram of frequency changes in the acceleration section of Embodiment (1) of the present invention. The fourth figure is a schematic diagram of the frequency change of the sustained segment in Embodiment (1) of the present invention. The fifth figure is a schematic diagram of frequency changes in the deceleration section of Embodiment (1) of the present invention. The sixth picture is a schematic diagram of the experimental effect of horizontal rhythm.
無without
1:加速段 1: Acceleration section
2:持續段 2: Sustained segment
3:減速段 3:Deceleration section
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