TW202330513A - ) inhibitors and methods using same - Google Patents

Abstract

The present disclosure relates to compounds, and compositions comprising the same, useful for the treatment, amelioration, and/or prevention of a coronavirus infection in a subject.

Description

Major protease (Mpro) inhibitors and methods of use thereof

Pursuant to 35 U.S.C. § 119(e), this application claims priority to U.S. Provisional Patent Application No. 63/249,450, filed September 28, 2021, and U.S. Provisional Patent Application No. 63/389,713, filed July 15, 2022, at This is hereby incorporated by reference in its entirety in its entirety.

The present disclosure relates to major protease (M ^pro ) inhibitors and methods of their use.

SARS-COV-2, a member of the human coronavirus family, is the causative agent of coronavirus disease 2019 (COVID-19). Initially identified in Wuhan in December 2019, the virus has since spread across the globe and was declared a pandemic by the World Health Organization on March 11, 2020. Although several vaccines are available to prevent COVID-19, there is an urgent need to reduce morbidity in patients who already have COVID-19, have not received the vaccine, and/or have been infected with more resistant variants of SARS-COV-2 and/or mortality with effective new drug treatments. Furthermore, these treatments may be essential for future coronavirus pandemics.

SARS-COV-2 is a straight-stranded, enveloped RNA virus. Like many coronaviruses, its genome includes six major open reading frames (ORFs), in addition to other accessory genes. Following extensive proteolytic processing, the polyproteins encoded by ORF 1a and ORF 1ab are involved in many fundamental tasks related to viral replication, transcription, viral assembly and immune response modulation. The processing to make the polyproteins encoded by ORF 1a and ORF 1ab functional depends on the main protease (ie, M ^pro or 3CL ^pro ). Thus, M ^pro is an essential element of the viral life cycle and represents a key therapeutic target for disruption of the viral life cycle.

There is therefore a need in the art for compounds and methods of using same for treating, ameliorating and/or preventing coronavirus infection in a subject. The present disclosure addresses this need.

The present disclosure provides certain compounds of formula (I), or salts, solvates, geometric isomers, stereoisomers or tautomers thereof, or any mixtures thereof, wherein the substituents in (I) are as described herein Defined elsewhere:

The present disclosure further provides pharmaceutical compositions comprising at least one compound of the present disclosure and at least one pharmaceutically acceptable carrier. In some embodiments, the pharmaceutical composition further includes at least one additional agent for treating, improving and/or preventing coronavirus infection.

The present disclosure further provides methods for treating, improving or preventing coronavirus infection. In certain embodiments, the method comprises administering to a subject in need thereof a therapeutically effective amount of at least one compound of the disclosure and/or at least one pharmaceutical composition of the disclosure. In certain embodiments, the coronavirus is selected from alphacoronaviruses and betacoronaviruses. In certain embodiments, the alphacoronavirus is selected from human coronavirus 229E (HCoV-229E) and human coronavirus NL63 (HCoV-NL63). In certain embodiments, the betacoronavirus is selected from severe acute respiratory syndrome-associated coronavirus 2 (SARS-CoV-2), severe acute respiratory syndrome-associated coronavirus 1 (SARS-CoV or SARS-CoV-1 ), Middle East respiratory syndrome-associated coronavirus (MERS-CoV), human coronavirus OC43 (HCoV-OC43) and human coronavirus HKU1 (HCoV-HKU1). In certain embodiments, the coronavirus major protease (M ^pro ) is inhibited. In certain embodiments, M ^pro is a 3C-like protease (3CL ^pro ).

In one aspect, the present invention provides compounds and compositions useful for treating, improving and/or preventing coronavirus infection, such as but not limited to SARS-CoV-2 infection. In certain embodiments, the compound inhibits the virus M ^pro .

Reference will now be made in detail to certain embodiments of the disclosed subject matter. While the disclosed subject matter will be described in conjunction with the enumerated claims, it will be understood that the illustrated subject matter is not intended to limit the claims to the disclosed subject matter.

Throughout the document, values expressed in range format should be interpreted in a flexible manner, including not only the numerical values explicitly listed as the boundaries of the range, but also all individual numerical values or subranges contained within that range, as if Each value and subrange is explicitly enumerated. For example, a range of "about 0.1% to about 5%" or "about 0.1% to 5%" should be construed to include not only about 0.1% to about 5%, but also individual values within the specified range (e.g., 1%, 2% , 3% and 4%) and subranges (such as 0.1% to 0.5%, 1.1% to 2.2%, 3.3% to 4.4%). Unless stated otherwise, the phrase "about X to Y" has the same meaning as "about X to about Y". Likewise, the phrase "about X, Y, or about Z" has the same meaning as "about X, about Y, or about Z" unless stated otherwise.

In this document, the terms "a", "an" or "the" are used to include one or more than one unless the context clearly dictates otherwise. Unless stated otherwise, the term "or" is used to refer to a non-exclusive "or". The statement "at least one of A and B" or "at least one of A or B" has the same meaning as "A, B, or A and B". Furthermore, it is to be understood that phraseology or terminology (rather than other definitions) employed herein are for the purpose of description rather than limitation. Any use of section headings is intended to aid in reading the document and should not be construed as limiting; information related to a section heading may appear within or outside of that particular section. All publications, patents, and patent documents cited in this document are hereby incorporated by reference in their entirety, as if individually incorporated by reference.

In the methods described herein, actions may be performed in any order, unless a temporal or operational sequence is explicitly stated. Furthermore, specified actions may be performed concurrently unless explicit declarative language states that they are performed separately. For example, it is possible to simultaneously Do claimed action X and claimed action Y, and the resulting process will fall within the literal scope of the claimed process.

definition

As used herein, each of the following terms has the meaning associated with it in this section. Unless defined otherwise, all technical and scientific terms used herein generally have the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure belongs. Generally, the nomenclature and laboratory procedures in animal pharmacology, pharmaceutical science, separation science and organic chemistry used herein are those well known and commonly used in the art. It should be understood that the order or order in which certain actions are performed is immaterial so long as the present teachings remain operable. Furthermore, two or more steps or operations may be performed concurrently.

As used herein, the articles "a" and "an" refer to one or more (ie, at least one) of the grammatical objects herein. By way of example, "an element" means one element or more than one element.

As used herein, unless otherwise stated, the term "alkenyl" alone or in combination with other terms refers to a stable monounsaturated or diunsaturated straight or branched chain hydrocarbon group having the specified number of carbon atoms. Examples include vinyl, propenyl (or allyl), crotyl, isopentenyl, butadienyl, 1,3-pentadienyl, 1,4-pentadienyl, and more High homologues and isomers. An example of a functional group representing an alkene is -CH ₂ -CH=CH ₂ .

As used herein, unless otherwise stated, the term "alkoxy" used alone or in combination with other terms means an alkoxy group, as defined elsewhere herein, having the specified number of carbon atoms, such as, for example, methoxy, ethoxy, 1-propoxy, 2-propoxy (or isopropoxy) and higher homologues and isomers. A specific example is (C ₁ -C ₃ )alkoxy such as, but not limited to, ethoxy and methoxy.

As used herein, unless otherwise stated, the term "alkyl" by itself or as part of another substituent means a group having the indicated number of carbon atoms (i.e., C ₁ -C ₁₀ represents 1 to 10 carbon atom), and include straight, branched or cyclic substituents. Examples include methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl, neopentyl, hexyl and cyclopropylmethyl. A particular embodiment is (C ₁ -C ₆ )alkyl such as, but not limited to, ethyl, methyl, isopropyl, isobutyl, n-pentyl, n-hexyl and cyclopropylmethyl.

As used herein, unless otherwise stated, the term "alkynyl" used alone or in combination with other terms refers to a stable straight or branched chain having a carbon-carbon triple bond having the specified number of carbon atoms. chain hydrocarbon group. Non-limiting examples include ethynyl and propynyl, and higher homologues and isomers. The term "propargylic" refers to a group exemplified by -CH ₂ -C≡CH. The term "homopropargylic" refers to a group exemplified by -CH ₂ CH ₂ -C≡CH.

As used herein, the term "aromatic" means having one or more polyunsaturated rings and having an aromatic character, i.e. having (4n+2) delocalized π(pi) electrons (where 'n' is Integer) carbocycle or heterocycle.

As used herein, unless otherwise stated, the term "aryl" alone or in combination with other terms means a carbocyclic aromatic group containing one or more rings (usually one, two or three rings). systems in which the rings can be linked together in a side-chain fashion, as in biphenyl, or can be fused, as in naphthalene. Examples include phenyl, anthracenyl and naphthyl. Aryl also includes, for example, a benzene or naphthalene ring fused to one or more saturated or partially saturated carbocycles (eg, bicyclo[4.2.0]octa-1,3,5-trienyl or indanyl) , which may be substituted at one or more carbon atoms of an aromatic ring and/or a saturated or partially saturated ring.

As used herein, the term "aryl-(C ₁ -C ₆ )alkyl" or "aralkyl" refers to a functional group in which 1 to 6 carboalkylene chains are attached to an aryl group, for example, -CH ₂ CH ₂ -phenyl or -CH ₂ -phenyl (or benzyl). Specific examples are aryl- _CH2- and aryl-CH( _CH3 )-. The term "substituted aryl-(C ₁ -C ₆ )alkyl" refers to an aryl-(C ₁ -C ₆ )alkyl functional group in which the aryl group is substituted. A specific example is substituted aryl (CH ₂ )-. Similarly, the term "heteroaryl-(C ₁ -C ₆ )alkyl" refers to a functional group in which 1 to 3 carboalkylene chains are attached to a heteroaryl, eg, -CH ₂ CH ₂ -pyridyl. A specific example is heteroaryl-( _CH2 )-. The term "substituted heteroaryl-(C ₁ -C ₆ )alkyl" refers to a heteroaryl-(C ₁ -C ₆ )alkyl functional group in which the heteroaryl is substituted. A specific example is substituted heteroaryl-( _CH2 )-.

In one aspect, the terms "co-administered" and "co-administered" in relation to a subject refer to administration of a compound and/or composition of the present disclosure to a subject and also to treat or prevent a disease or condition contemplated herein compounds and/or compositions. In certain embodiments, co-administered compounds and/or compositions are administered alone or in any kind of combination as part of a monotherapy approach. The co-administered compounds and/or compositions may be formulated in any kind of combination as solid and liquid mixtures and solutions of various solid, gel and liquid formulations.

"COVID" or "COVID-19" as used herein refers to coronavirus disease 2019, an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-COV-2).

As used herein, unless otherwise stated, the term "cycloalkyl" by itself or as part of another substituent refers to a cyclic chain hydrocarbon having the specified number of carbon atoms (i.e., C ₃ -C ₆ means including cyclic groups consisting of 3 to 6 carbon atoms) and include linear, branched or cyclic substituents. Examples of (C ₃ -C ₆ )cycloalkyl are cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl. Cycloalkyl rings can be optionally substituted. Non-limiting examples of cycloalkyl include: cyclopropyl, 2-methyl-cyclopropyl, cyclopropenyl, cyclobutyl, 2,3-dihydroxycyclobutyl, cyclobutenyl, cyclopentyl, Cyclopentenyl, cyclopentadienyl, cyclohexyl, cyclohexenyl, cycloheptyl, cyclooctyl, decalinyl, 2,5-dimethylcyclopentyl, 3,5-dichlorocyclo Hexyl, 4-hydroxycyclohexyl, 3,3,5-trimethylcyclohex-1-yl, octahydropentenyl, octahydro-1 H -indenyl, 3a,4,5,6,7,7a - hexahydro- 3H -inden-4-yl, decahydroazulenyl; bicyclo[6.2.0]decyl, decahydronaphthyl and dodecahydro- 1H -perylene. The term "cycloalkyl" also includes bicyclic hydrocarbon rings, non-limiting examples of which include bicyclo[2.1.1]hexyl, bicyclo[2.2.1]heptanyl, bicyclo[3.1.1]heptanyl, 1, 3-Dimethyl[2.2.1]heptan-2-yl, bicyclo[2.2.2]octanyl and bicyclo[3.3.3]undecyl.

As used herein, the term "DCM" refers to dichloromethane.

As used herein, a "disease" is a state of health of a subject in which the subject is unable to maintain homeostasis, and if the disease is not ameliorated, the subject's health continues to deteriorate.

As used herein, a "condition" in a subject is a state of health in which the subject is able to maintain homeostasis, but wherein the subject's state of health is less favorable than it would be in the absence of the condition. If left untreated, the condition does not necessarily lead to a further decline in the subject's health status.

As used herein, the term "halide" refers to a negatively charged halogen atom. Halide anions are fluoride (F ⁻ ), chloride (Cl ⁻ ), bromide (Br ⁻ ) and iodide (I ⁻ ).

As used herein, unless otherwise stated, the term "halo" or "halogen" alone or as part of another substituent refers to a fluorine, chlorine, bromine or iodine atom.

"Haloalkyl" as used herein includes monohaloalkyl, polyhaloalkyl (wherein all halogen atoms may be the same or different) and perhaloalkyl (wherein all hydrogen atoms are independently selected and/or the same halogen atoms, such as fluorine Substituted. Examples of haloalkyl include trifluoromethyl, 1,1-dichloroethyl, 1,2-dichloroethyl, 1,3-dibromo-3,3-difluoropropyl, perfluorobutyl wait.

As used herein, unless otherwise stated, the term "heteroalkenyl" by itself or in combination with another term refers to a stable A linear or branched monounsaturated or diunsaturated hydrocarbon group, and wherein the nitrogen atom and the sulfur atom may be optionally oxidized, and the nitrogen heteroatom may be optionally quaternized. Up to two heteroatoms can be placed consecutively. Examples include -CH=CH-O-CH ₃ , -CH=CH-CH ₂ -OH, -CH ₂ -CH=N-OCH ₃ , -CH=CH-N(CH ₃ )-CH ₃ and -CH ₂ -CH=CH- _CH2 -SH.

As used herein, unless otherwise stated, the term "heteroalkyl" by itself or in combination with another term refers to a stable A straight or branched chain alkyl group, and wherein the nitrogen atom and the sulfur atom may be optionally oxidized, and the nitrogen heteroatom may be optionally quaternized. The heteroatom(s) can be located anywhere on the heteroalkyl, including between the remainder of the heteroalkyl and fragments to which it is attached, and attached to the most distal carbon atom in the heteroalkyl. _{Examples include : -OCH2CH2CH3 , -CH2CH2CH2OH , -CH2CH2NHCH3} , _-CH2SCH2CH3 and _-CH2CH2S ( _{= O ) CH3 .} Up to two heteroatoms may be _{consecutive ,} such as for example _-CH2NH - _OCH3 or _-CH2CH2SSCH3 .

As used herein, the term "heteroaryl" or "heteroaromatic" refers to a heterocyclic ring having aromatic character. Polycyclic heteroaryl groups may include one or more partially saturated rings. Examples include tetrahydroquinoline and 2,3-dihydrobenzofuranyl.

As used herein, unless otherwise stated, the term "heterocycle" or "heterocyclyl" or "heterocyclic" by itself or as part of another substituent means comprising carbon atoms and elements selected from the group consisting of N, O and An unsubstituted or substituted, stable monocyclic or polycyclic heterocyclic ring system of at least one heteroatom of S, and wherein the nitrogen and sulfur heteroatoms can be optionally oxidized, and the nitrogen atom can be optionally quaternized. Unless otherwise stated, the heterocyclic ring system can be attached at any heteroatom or carbon atom that provides a stable structure. Heterocycles can be aromatic or non-aromatic in nature. In certain embodiments, the heterocycle is heteroaryl.

、嗎啉、硫代嗎啉、哌喃、2,3-二氫哌喃、四氫哌喃、1,4-二

烷、1,3-二

烷、高哌

、高哌啶、1,3-二氧雜環庚烷、4,7-二氫-1,3-二噁庚(dioxepin)和環氧己烷(hexamethyleneoxide)。 Examples of non-aromatic heterocycles include monocyclic groups such as aziridine, oxirane, thiirane, azetidine, oxetane, thietane, pyrrole Pyridine, pyrroline, imidazoline, pyrazolidine, dioxolane, cyclobutane, 2,3-dihydrofuran, 2,5-dihydrofuran, tetrahydrofuran, tetrahydrothiophene, piperidine, 1,2, 3,6-tetrahydropyridine, 1,4-dihydropyridine, piperidine

, morpholine, thiomorpholine, pyran, 2,3-dihydropyran, tetrahydropyran, 1,4-dihydropyran

Alkane, 1,3-bis

alkane, homopiper

, Homopiperidine, 1,3-dioxepane, 4,7-dihydro-1,3-dioxepin (dioxepin) and epoxyhexane (hexamethyleneoxide).

基、嘧啶基(比如，但不限於2-和4-嘧啶基)、嗒

基、噻吩基、呋喃基、吡咯基、咪唑基、噻唑基、

唑基、吡唑基、異噻唑基、1,2,3-三唑基、1,2,4-三唑基、1,3,4-三唑基、四唑基、1,2,3-噻唑基、1,2,3-

二唑基、1,3,4-噻唑基和1,3,4-

二唑基。 Examples of heteroaryl groups include pyridyl, pyridyl

base, pyrimidinyl (such as, but not limited to, 2- and 4-pyrimidinyl), pyridyl

base, thienyl, furyl, pyrrolyl, imidazolyl, thiazolyl,

Azolyl, pyrazolyl, isothiazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, 1,3,4-triazolyl, tetrazolyl, 1,2,3 -Thiazolyl, 1,2,3-

Diazolyl, 1,3,4-thiazolyl and 1,3,4-

Diazolyl.

啉基(cinnolinyl)、喹

啉基(比如，但不限於2-和5-喹

啉基)、喹唑啉基、呔

基、1,8-

啶基、1,4-苯并二

烷基、香豆素、二氫香豆素、1,5-

啶基、苯并呋喃基(比如，但不限於3-、4-、5-、6-和7-苯并呋喃基)、2,3-二氫苯并呋喃基、1,2-苯并

唑基、苯并噻吩基(比如，但不限於3-、4-、5-、6-和7-苯并噻吩基)、苯并

唑基、苯并噻唑基(比如，但不限於2-苯并噻唑基和5-苯并噻唑基)、嘌呤基、苯并咪唑基、苯并三唑基、硫代黃嘌呤基(thioxanthinyl)、咔唑基、咔啉基、吖啶基、吡咯啶基(pyrrolizidinyl)和喹

啶基(quinolizidinyl)。 Examples of polycyclic heterocycles include indolyl (such as, but not limited to, 3-, 4-, 5-, 6-, and 7-indolyl), indolinyl, quinolinyl, tetrahydroquinolyl , isoquinolinyl (such as, but not limited to, 1- and 5-isoquinolinyl), 1,2,3,4-tetrahydroisoquinolinyl,

Cinnolinyl (cinnolinyl), quinone

Linyl (such as, but not limited to, 2- and 5-quinolinyl

Linyl), Quinazolinyl, Tie

base, 1,8-

Pyridyl, 1,4-benzodi

Alkyl, coumarin, dihydrocoumarin, 1,5-

Pyridyl, benzofuryl (such as, but not limited to, 3-, 4-, 5-, 6-, and 7-benzofuryl), 2,3-dihydrobenzofuryl, 1,2-benzofuryl

Azolyl, benzothienyl (such as, but not limited to, 3-, 4-, 5-, 6-, and 7-benzothienyl), benzothienyl

Azolyl, benzothiazolyl (such as, but not limited to, 2-benzothiazolyl and 5-benzothiazolyl), purinyl, benzimidazolyl, benzotriazolyl, thioxanthinyl , carbazolyl, carbolinyl, acridinyl, pyrrolidinyl (pyrrolizidinyl) and quinone

Quinolizidinyl.

The above listing of heterocyclyl and heteroaryl moieties is intended to be representative and not limiting.

As used herein, the term "pharmaceutical composition" or "composition" refers to a mixture of at least one compound useful in the present disclosure and a pharmaceutically acceptable carrier. Pharmaceutical compositions facilitate administration of a compound to a subject.

As used herein, the term "pharmaceutically acceptable" refers to a material, such as a carrier or diluent, that does not abrogate the biological activity or properties of the compounds useful in the present disclosure and is relatively nontoxic, i.e., can be produced without causing adverse biological effects. The material is administered to a subject without affecting or interacting in a deleterious manner with any component of the composition comprising it.

As used herein, the term "pharmaceutically acceptable carrier" refers to a pharmaceutically acceptable carrier that participates in carrying or transporting a compound useful in the present disclosure in or to a subject so that it can perform its intended function. Acceptable materials, compositions or carriers, such as liquid or solid fillers, stabilizers, dispersants, suspending agents, diluents, excipients, thickeners, solvents or encapsulating materials. Typically, such constructs are carried or transported from one organ or part of the body to another organ or part of the body. Each carrier must be "acceptable" in the sense of being compatible with the other ingredients of the formulation, including compounds useful in the present disclosure, and not injurious to the subject. Some examples of materials that can be used as pharmaceutically acceptable carriers Includes: sugars, such as lactose, glucose, and sucrose; starches, such as cornstarch and potato starch; cellulose and its derivatives, such as sodium carboxymethylcellulose, ethylcellulose, and cellulose acetate; powdered tragacanth gum; Malt; gelatin; talc; excipients, such as cocoa butter and suppository waxes; oils, such as peanut, cottonseed, safflower, sesame, olive, corn, and soybean oils; glycols, such as propylene glycol; polyols, such as Glycerin, sorbitol, mannitol, and polyethylene glycol; esters, such as ethyl oleate and ethyl laurate; agar; buffers, such as magnesium hydroxide and aluminum hydroxide; surfactants; alginic acid; athermal Raw water; isotonic saline; Ringer's solution; ethanol; phosphate buffered saline; and other nontoxic compatible substances used in pharmaceutical formulations. As used herein, "pharmaceutically acceptable carrier" also includes any and all coatings, antibacterial and antibacterial agents that are compatible with the activity of the compounds useful in this disclosure and that are physiologically acceptable to the subject. Fungal agents, and absorption delaying agents, etc. Supplementary active compounds can also be incorporated into the compositions. A "pharmaceutically acceptable carrier" can further include pharmaceutically acceptable salts of compounds useful in this disclosure. Other additional ingredients that may be included in pharmaceutical compositions used in the practice of the present disclosure are known in the art and described, for example, in Remington Pharmaceutical Sciences (Genaro, Ed., Mack Publishing Co., 1985, Easton , PA), which is incorporated herein by reference.

As used herein, the language "pharmaceutically acceptable salt" refers to pharmaceutically acceptable salts consisting of inorganic acids, inorganic alkalis, organic acids, inorganic alkalis, solvates (including hydrates) and clathrates thereof. Salts of the administration compounds prepared from acceptable non-toxic acids and/or alkalis.

As used herein, a "pharmaceutically effective amount", "therapeutically effective amount" or "effective amount" of a compound is an amount of the compound sufficient to provide a beneficial effect to a subject to which the compound is administered.

As used herein, the terms "prevent," "prevent," and "avoid" refer to avoiding or delaying symptoms associated with a disease or disorder in subjects who do not develop such symptoms at the time of initiation of administration of an agent or compound. attack. Disease, condition and disorder are used interchangeably herein.

The term "specifically binds" or "specifically binds" as used herein means that a first molecule binds preferentially to a second molecule (eg, a particular receptor or enzyme), but not necessarily only to that second molecule.

As used herein, the terms "subject" and "individual" and "patient" are used interchangeably and may refer to a human or non-human mammal or bird. Non-human mammals include, for example, livestock and pets, such as ovine, bovine, porcine, canine, feline, and murine mammals. In certain embodiments, the subject is a human.

As used herein, the term "substituted" means that an atom or group of atoms has replaced a hydrogen as a substituent attached to another group.

As used herein, the term "substituted alkyl", "substituted cycloalkyl", "substituted alkenyl" or "substituted alkynyl" means an alkyl, cycloalkyl, , alkenyl or alkynyl, which are independently selected from halogen, -OH, alkoxy, tetrahydro-2-H-pyranyl, -NH ₂ , -NH(C ₁ -C ₆ alkyl), - N(C ₁ -C ₆ alkyl) ₂ , 1-methyl-imidazol-2-yl, pyridin-2-yl, pyridin-3-yl, pyridin-4-yl, -C(=O)OH, - C(=O)O(C ₁ -C ₆ )alkyl, trifluoromethyl, -C≡N, -C(=O)NH ₂ , -C(=O)NH(C ₁ -C ₆ )alkane group, -C(=O)N((C ₁ -C ₆ )alkyl) ₂ , -SO ₂ NH ₂ , -SO ₂ NH(C ₁ -C ₆ alkyl), -SO ₂ N(C ₁ - C ₆ alkyl) ₂ , -C(=NH)NH ₂ and -NO ₂ are substituted with one, two or three substituents, in certain embodiments containing independently selected from halogen, -OH, alkoxy , -NH ₂ , trifluoromethyl, -N(CH ₃ ) ₂ , and one or two substituents of -C(=O)OH, independently selected in certain embodiments from halogen, alkoxy, and - Oh. Examples of substituted alkyl groups include, but are not limited to, 2,2-difluoropropyl, 2-carboxycyclopentyl, and 3-chloropropyl.

For aryl, aryl-(C ₁ -C ₃ )alkyl, and heterocyclyl, the term "substituted" applied to the rings of these groups means any level of substitution where such substitution is permissible, i.e. mono , two, three, four or five substitutions. Substituents are independently selected, and substitution can be at any chemically accessible position. In certain embodiments, the number of substituents varies between 1 and 4. In other embodiments, the number of substituents varies between 1 and 3. In another embodiment, the number of substituents varies between 1 and 2. In yet other embodiments, the substituents are independently selected from C ₁ -C ₆ alkyl, —OH, C ₁ -C ₆ alkoxy, halogen, amine, acetamido, and nitro. As used herein, when a substituent is an alkyl or alkoxy group, the carbon chain may be branched, straight or cyclic.

Unless otherwise stated, when two substituents are taken together to form a ring having the indicated number of ring atoms (for example, ^R2 and ^R3 together with the nitrogen to which they are attached form a ring having 3 to 7 ring members), the ring There may be carbon atoms and optionally one or more (eg, 1 to 3) additional heteroatoms independently selected from nitrogen, oxygen or sulfur. The ring may be saturated or partially saturated and may be optionally substituted.

Whenever either the term or its prefixed root appears in the name of a substituent, that name should be construed as including those limitations provided herein. For example, whenever the term "alkyl" or "aryl" or either of its prefixed radicals appears in the name of a substituent (e.g., arylalkyl, alkylamino), that name should be construed to include Those limitations given elsewhere for "alkyl" and "aryl" respectively.

In certain embodiments, substituents of compounds are disclosed in groups or ranges. It is specifically intended that this description include each and every individual subcombination of members of such groups and ranges. For example, the term "C _1-6 alkyl" is expressly intended to disclose individually C ₁ , C ₂ , C ₃ , C ₄ , C ₅ , C ₆ , C ₁ -C ₆ , C ₁ -C ₅ , C ₁ - C ₄ , C ₁ -C ₃ , C ₁ -C ₂ , C ₂ -C ₆ , C ₂ -C ₅ , C ₂ -C ₄ , C ₂ -C ₃ , C ₃ -C ₆ , C ₃ -C ₅ , C ₃ -C ₄ , C ₄ -C ₆ , C ₄ -C ₅ and C ₅ -C ₆ alkyl.

The terms "treat", "treat" and "treat" as used herein refer to reducing the frequency or severity with which a subject experiences symptoms of a disease or disorder by administering an agent or compound to the subject.

Scope: Throughout this disclosure, various aspects of the disclosure may be presented in a range format. It should be understood that the description in range format is merely for convenience and brevity and should not be construed as an inflexible limitation on the scope of the present disclosure. Accordingly, the description of a range should be considered as having expressly disclosed all the possible subranges and individual values within that range. For example, a description of a range such as from 1 to 6 should be considered to have explicitly disclosed subranges such as from 1 to 3, from 1 to 4, from 1 to 5, from 2 to 4, from 2 to 6, from 3 to 6 etc., and individual values and sub-values within the range, for example, 1, 2, 2.7, 3, 4, 5, 5.3 and 6. This applies regardless of the breadth of the scope.

compound

The present disclosure provides a compound of formula (I), or a salt, solvate, geometric isomer, stereoisomer, tautomer or any mixture thereof:

in:

、

、

、 R ¹ is selected from

,

,

,

R ^2a and R ^2b are each independently selected from H, optionally substituted C ₁ -C ₁₂ alkyl, optionally substituted C ₃ -C ₁₂ cycloalkyl, optionally substituted C ₂ -C ₁₂ hetero Cyclic and C ₇ -C ₁₂ aralkyl,

； wherein R ^2a and R ^A and one or more of R ^2a and R ^2b may be combined with the atoms to which they are bonded to form an optionally substituted C _3- C ₁₂ heterocyclyl or an optionally substituted C ₃ -C ₁₂ cycloalkyl, wherein two optional substituents thereof can combine with the atoms to which they are bonded to form optionally substituted C ₃ -C ₁₂ cycloalkyl, optionally substituted C ₂ -C ₁₂ heterocyclyl or optionally substituted phenyl; R ³ is

;

L is selected from optionally substituted C ₁ -C ₃ alkylene, -C(=O)-*, -C(=O)(optionally substituted C ₁ -C ₂ alkylene)-*, -(optionally substituted C ₁ -C ₂ alkylene)-C(=O)-* and a bond, wherein * represents the bond between L and R ^4a ;

R ^4a is selected from optionally substituted phenyl, optionally substituted C ₂ -C ₉ heteroaryl,

Wherein in R ^4a , optionally substituted phenyl or optionally substituted C ₂ -C ₉ heteroaryl is substituted by at least one halogen; R ^4b is H;

、

和

； R ^4c is selected from

,

and

;

R ^5a is selected from H, -C(=O) (optionally substituted C ₁ -C ₆ alkyl), -C(=O) (C ₁ -C ₆ haloalkyl) and optionally substituted C ₁ -C ₆ alkyl;

R ^5b is selected from H, optionally substituted C ₁ -C ₆ alkyl and optionally substituted C ₂ -C ₆ alkenyl;

^R is selected from H and halogen;

R ^6a is selected from H, optionally substituted C ₁ -C ₆ alkyl and optionally substituted phenyl;

^R6b is H,

or R ^6a and R ^6b are combined with the carbon atoms to which they are bonded to form an optionally substituted C ₃ -C ₈ cycloalkyl;

R ^6c is selected from C(=O) (optionally substituted C ₁ -C ₆ haloalkyl), C(=O) (optionally substituted C ₁ -C ₆ alkyl), optionally substituted C ₂ -C _Heteroaryl and optionally substituted phenyl;

R ^7a and R ^7b (if present) are each independently selected from H, halogen, OR ^B , optionally substituted C ₁ -C ₆ alkyl, optionally substituted C ₃ -C ₈ cycloalkyl, optionally Ground substituted C ₂ -C ₉ heterocyclyl and optionally substituted naphthyl;

Each occurrence of R ^a1 , R ^a2 , R ^a3 , R ^a4 , R ^a5 , R ^a6 , R ^a7 , R ^a8 , R ^a9 and R ^a10 (if present) is independently selected from H, halogen, CN, NO ₂ , Optionally substituted C ₁ -C ₆ alkyl, optionally substituted C ₃ -C ₈ cycloalkyl, optionally substituted C ₁ -C ₆ alkoxy, optionally substituted C ₃ -C ₈ cycloalkoxy, optionally substituted C ₂ -C ₉ heterocycloalkyl, optionally substituted phenyl, optionally substituted naphthyl, optionally substituted C ₂ -C ₉ heteroaryl , OR ^B , N(R ^B )(R ^C ), NO ₂ , C(=O)N(R ^B )(R ^C ), C(=O)R ^B , C(=O)OR ^B , OC( =O)R ^B , OC(=O)OR ^B , SR ^B , S(=O)R ^B , S(=O) ₂ R ^B , N(R ^B )S(=O) ₂ R ^C , N( R ^B )C(=O)R ^C and S(=O) ₂ N(R ^B )(R ^C );

Each occurrence of R ^b1 , R ^b2 and R ^b3 (if present) is independently selected from H, halogen, optionally substituted C ₁ -C ₆ alkyl, optionally substituted C ₃ -C ₈ cycloalkyl , optionally substituted C ₁ -C ₆ alkoxy, optionally substituted C ₃ -C ₈ cycloalkoxy, optionally substituted C ₂ -C ₈ heterocycloalkyl, optionally substituted Phenyl, optionally substituted naphthyl, optionally substituted C ₂ -C ₉ heteroaryl, C(=O)N(R ^B )(R ^C ), C(=O) ^RB , C( =O)OR ^B , S(=O) ^RB , S(=O) ₂ R ^B and S(=O) ₂ N(R ^B )(R ^C ),

wherein two pairs of substituents selected from R ^b1 , R ^b2 and R ^b3 can be combined with the carbon atoms to which they are bonded to form an optionally substituted C ₂ -C ₈ heterocycloalkyl or an optionally substituted C ₃ -C ₈ cycloalkyl;

Each occurrence of R ^c1 , R ^c2 , R ^c3 , R ^c4 , R ^c5 , R ^c6 , R ^c7 , R ^c8 , R ^c9 , R ^c10 and R ^c11 (if present) is independently selected from H, halogen, CN, NO ₂ , optionally substituted C ₁ -C ₆ alkyl, optionally substituted C ₃ -C ₈ cycloalkyl, optionally substituted C ₁ -C ₆ alkoxy, optionally substituted C ₃ -C ₈ cycloalkoxy, heterocyclyl, phenyl, naphthyl, heteroaryl, OR ^B , N(R ^B )(R ^C ), NO ₂ , C(=O)N(R ^B )( R ^C ), C(=O)R ^B , C(=O)OR ^B , OC(=O)R ^B , OC(=O)OR ^B , SR ^B , S(=O)R ^B , S(= O) ₂ R ^B , N( ^RB )S(=O) ₂ R ^C , N( ^RB )C(=O)R ^C and S(=O) ₂ N( ^RB )(R ^C );

Each occurrence of R ^A , R ^B and R ^C is independently selected from H, -C(=O) (optionally substituted C ₁ -C ₆ alkyl), -C(=O) (optionally substituted C ₁ -C ₆ haloalkyl), optionally substituted C ₁ -C ₆ alkyl, optionally substituted C ₁ -C ₃ haloalkyl, optionally substituted C ₃ -C ₈ cycloalkyl, Optionally substituted C ₁ -C ₆ alkoxy and optionally substituted C ₃ -C ₈ cycloalkoxy, optionally substituted phenyl, optionally substituted naphthyl and optionally substituted C ₂ -C ₉ heteroaryl;

^RD is selected from H, -C( ⁼ O) ^RB and -S(=O) _2RB ;

R ^E is selected from H, C ₁ -C ₆ alkyl and C ₁ -C ₆ haloalkyl;

each occurrence of X is independently selected from O, S and N( ^RB );

Y (if present) is selected from I, Br, Cl, F and OR ^D ;

Z ^and Z are ^each independently selected from H and halogen; and

Wherein if ^R is 4-methoxy- 1H -indolyl, at least one of the following applies:

(a) R ^2a is not isopropyl and R ^2b is not H,

(b) R ^2a is not H and R ^2b is not isopropyl or

(c) R ^4a is not -C(=O)CH ₂ OH or -C(=O)CH ₂ OP(=O)(OH) ₂ .

In certain embodiments, each of R ^a1 , R ^a2 , R ^a3 , R ^a4 , R ^a5 , R ^a6 , R ^a7 , R ^a8 , R ^a9 , and R ^a10 (if present) is H. In certain embodiments, nine of R ^a1 , R ^a2 , R ^a3 , R ^a4 , R ^a5 , R ^a6 , R ^a7 , R ^a8 , R ^a9 , and R ^a10 (if present) are H. In certain embodiments, eight of R ^a1 , R ^a2 , R ^a3 , R ^a4 , R ^a5 , R ^a6 , R ^a7 , R ^a8 , R ^a9 , and R ^a10 (if present) are H. In certain embodiments, seven of R ^a1 , R ^a2 , R ^a3 , R ^a4 , R ^a5 , R ^a6 , R ^a7 , R ^a8 , R ^a9 , and R ^a10 (if present) are H. In certain embodiments, six of R ^a1 , R ^a2 , R ^a3 , R ^a4 , R ^a5 , R ^a6 , R ^a7 , R ^a8 , R ^a9 , and R ^a10 (if present) are H. In certain embodiments, five of R ^a1 , R ^a2 , R ^a3 , R ^a4 , R ^a5 , R ^a6 , R ^a7 , R ^a8 , R ^a9 , and R ^a10 (if present) are H. In certain embodiments, four of R ^a1 , R ^a2 , R ^a3 , R ^a4 , R ^a5 , R ^a6 , R ^a7 , R ^a8 , R ^a9 , and R ^a10 (if present) are H. In certain embodiments, three of R ^a1 , R ^a2 , R ^a3 , R ^a4 , R ^a5 , R ^a6 , R ^a7 , R ^a8 , R ^a9 , and R ^a10 (if present) are H. In certain embodiments, two of R ^a1 , R ^a2 , R ^a3 , R ^a4 , R ^a5 , R ^a6 , R ^a7 , R ^a8 , R ^a9 , and R ^a10 (if present) are H. In certain embodiments, one of R ^a1 , R ^a2 , R ^a3 , R ^a4 , R ^a5 , R ^a6 , R ^a7 , R ^a8 , R ^a9 and R ^a10 (if present) is H.

In certain embodiments, R ^a1 is H. In certain embodiments, R ^a1 is Me. In certain embodiments, R ^a1 is Cl. In certain embodiments, R ^a1 is F. In certain embodiments, R ^a1 is OMe. In certain embodiments, R ^a1 is _CF2H . In certain embodiments, ^Ra1 is Br.

In certain embodiments, ^Ra2 is H. In certain embodiments, R ^a2 is Me. In certain embodiments, ^Ra2 is Cl. In certain embodiments, ^Ra2 is F. In certain embodiments, R ^a2 is OMe. In certain embodiments, R ^a2 is CF ₂ H. In certain embodiments, ^Ra2 is Br.

In certain embodiments, ^Ra3 is H. In certain embodiments, R ^a3 is Me. In certain embodiments, ^Ra3 is Cl. In certain embodiments, R ^a3 is F. In certain embodiments, R ^a3 is OMe. In certain embodiments, R ^a3 is CF ₂ H. In certain embodiments, ^Ra3 is Br.

In certain embodiments, ^Ra4 is H. In certain embodiments, R ^a4 is Me. In certain embodiments, ^Ra4 is Cl. In certain embodiments, R ^a4 is F. In certain embodiments, R ^a4 is OMe. In certain embodiments, R ^a4 is CF ₂ H. In certain embodiments, ^Ra4 is Br.

In certain embodiments, ^Ra5 is H. In certain embodiments, R ^a5 is Me. In certain embodiments, ^Ra5 is Cl. In certain embodiments, R ^a5 is F. In certain embodiments, R ^a5 is OMe. In certain embodiments, R ^a5 is CF ₂ H. In certain embodiments, ^Ra5 is Br.

In certain embodiments, ^Ra6 is H. In certain embodiments, R ^a6 is Me. In certain embodiments, ^Ra6 is Cl. In certain embodiments, R ^a6 is F. In certain embodiments, R ^a6 is OMe. In certain embodiments, R ^a6 is CF ₂ H. In certain embodiments, ^Ra6 is Br.

In certain embodiments, ^Ra7 is H. In certain embodiments, R ^a7 is Me. In certain embodiments, ^Ra7 is Cl. In certain embodiments, R ^a7 is F. In certain embodiments, R ^a7 is OMe. In certain embodiments, R ^a7 is CF ₂ H. In certain embodiments, ^Ra7 is Br.

In certain embodiments, ^Ra8 is H. In certain embodiments, R ^a8 is Me. In certain embodiments, ^Ra8 is Cl. In certain embodiments, R ^a8 is F. In certain embodiments, R ^a8 is OMe. In certain embodiments, R ^a8 is CF ₂ H. In certain embodiments, ^Ra8 is Br.

In certain embodiments, ^Ra9 is H. In certain embodiments, R ^a9 is Me. In certain embodiments, ^Ra9 is Cl. In certain embodiments, R ^a9 is F. In certain embodiments, R ^a9 is OMe. In certain embodiments, R ^a9 is CF ₂ H. In certain embodiments, ^Ra9 is Br.

In certain embodiments, R ^a10 is H. In certain embodiments, R ^a10 is Me. In certain embodiments, R ^a10 is Cl. In certain embodiments, R ^a10 is F. In certain embodiments, R ^a10 is OMe. In certain embodiments, R ^a10 is CF ₂ H. In certain embodiments, R ^a10 is Br.

In certain embodiments, the compound of formula (I) is:

In certain embodiments, the compound of formula (I) is:

In certain embodiments, the compound of formula (I) is selected from:

in:

R ⁸ is selected from H, optionally substituted C ₁ -C ₆ alkyl, optionally substituted C ₂ -C ₆ alkenyl, optionally substituted C ₃ -C ₈ cycloalkyl, optionally substituted C ₂ -C ₉ heterocyclyl, optionally substituted phenyl, optionally substituted naphthyl, optionally substituted C ₂ -C ₉ heteroaryl,

wherein each of the optionally substituted C ₁ -C ₆ alkyl, the optionally substituted C ₂ -C ₉ heteroaryl and the optionally substituted phenyl is optionally selected from the group consisting of C ₁ -C ₆ alkyl , C ₁ -C ₆ alkoxy and optionally substituted pyridyl by at least one substituent; and R ^d1 , R ^d2 , R ^d3 , R d4 , R ^d5 , R ^d6 , R ^{d7 ,} R ^d8 , R Each occurrence of ^d9 and ^Rd10 (if present) is independently selected from H, halogen, CN, _NO2 , optionally substituted _C1 - _C6 alkyl, optionally substituted _C3 - _C8 cycloalkane radical, optionally substituted C ₁ -C ₆ alkoxy, optionally substituted C ₃ -C ₈ cycloalkoxy, heterocyclyl, phenyl, naphthyl, heteroaryl, OR ^B , N( R ^B )(R ^C ), NO ₂ , C(=O)N(R ^B )(R ^C ), C(=O)R ^B , C(=O)OR ^B , OC(=O)R ^B , OC(=O)OR ^B , SR ^B , S(=O)R ^B , S(=O) ₂ R ^B , N(R ^B )S(=O) ₂ R ^C , N(R ^B )C(= O)R ^C and S(=O) ₂ N(R ^B )(R ^C ),

wherein two substituents selected from R ^d1 , R ^d2 , R ^d3 , R ^d4 , R ^d5 , R ^d6 , R ^d7 , R ^d8 , R ^d9 and R ^{d10 -} can combine with the atoms to which they are bonded to form Optionally substituted C ₃ -C ₈ cycloalkyl or optionally substituted C ₂ -C ₈ heterocycloalkyl.

(Ib-1)。在某些實施方式中，式(I)的化合物是：

。在某些實施方式中，式(I)的化合物是：

。在某些實施方式中，式(I)的化合物是：

。在某些實施方 式中，式(I)的化合物是：

。在某些實施方式中，式(I)的化合物是：

。在某些實施方式中，式(I)的 化合物是：

。在某些實施方式中，式(I)的化合物是：

。在某些實施方式中，式(I)的化合物是：

。在某些實施方式中，式(I)的化合物是：

。在某些實施方式中，式(I)的化合物是：

。在某些實施方式中，式(I)的化合物是：

。在某些實施方式中，式(I)的化合物是

。在某些實施方式中，式(I)的化合物是： In certain embodiments, the compound of formula (I) is:

(Ib-1). In certain embodiments, the compound of formula (I) is:

. In certain embodiments, the compound of formula (I) is:

. In certain embodiments, the compound of formula (I) is:

. In certain embodiments, the compound of formula (I) is:

. In certain embodiments, the compound of formula (I) is:

. In certain embodiments, the compound of formula (I) is:

. In certain embodiments, the compound of formula (I) is:

. In certain embodiments, the compound of formula (I) is:

. In certain embodiments, the compound of formula (I) is:

. In certain embodiments, the compound of formula (I) is:

. In certain embodiments, the compound of formula (I) is:

. In certain embodiments, the compound of formula (I) is

. In certain embodiments, the compound of formula (I) is:

2’)。在某些實施方式中，式(I)的化合物是：

。在某些實施方式中，式(I)的化合物是：

。在某些實施方式中，式(I)的化合物是：

。在某些實施方式中，式(I)的化合物是：

。在某些實施方式中，式(I)的化合物是：

。在某些實施方式中，式(I)的化合物是：

。在某些實施方式中，式(I)的化合物是：

。在某些實施方式中，式(I)的化合物是： In certain embodiments, the compound of formula (I) is:

2'). In certain embodiments, the compound of formula (I) is:

. In certain embodiments, the compound of formula (I) is:

. In certain embodiments, the compound of formula (I) is:

. In certain embodiments, the compound of formula (I) is:

. In certain embodiments, the compound of formula (I) is:

. In certain embodiments, the compound of formula (I) is:

. In certain embodiments, the compound of formula (I) is:

. In certain embodiments, the compound of formula (I) is:

In certain embodiments, each of ^Rd1 , ^Rd2 , ^Rd3 , ^Rd4 , ^Rd5 , ^Rd6 , ^Rd7 , ^Rd8 , ^Rd9 , and ^Rd10 (if present) is H. In certain embodiments, nine of ^Rd1 , ^Rd2 , ^Rd3 , ^Rd4 , ^Rd5 , ^Rd6 , ^Rd7 , ^Rd8 , ^Rd9 , and ^Rd10 (if present) are H. In certain embodiments, eight of ^Rd1 , ^Rd2 , ^Rd3 , ^Rd4 , ^Rd5 , ^Rd6 , ^Rd7 , ^Rd8 , ^Rd9 , and ^Rd10 (if present) are H. In certain embodiments, seven of ^Rd1 , ^Rd2 , ^Rd3 , ^Rd4 , ^Rd5 , ^Rd6 , ^Rd7 , ^Rd8 , ^Rd9 , and ^Rd10 (if present) are H. In certain embodiments, six of ^Rd1 , ^Rd2 , ^Rd3 , ^Rd4 , ^Rd5 , ^Rd6 , ^Rd7 , ^Rd8 , ^Rd9 , and ^Rd10 (if present) are H. In certain embodiments, five of ^Rd1 , ^Rd2 , ^Rd3 , ^Rd4 , ^Rd5 , ^Rd6 , ^Rd7 , ^Rd8 , ^Rd9 , and ^Rd10 (if present) are H. In certain embodiments, four of ^Rd1 , ^Rd2 , ^Rd3 , ^Rd4 , ^Rd5 , ^Rd6 , ^Rd7 , ^Rd8 , ^Rd9 , and ^Rd10 (if present) are H. In certain embodiments, three of ^Rd1 , ^Rd2 , ^Rd3 , ^Rd4 , ^Rd5 , ^Rd6 , ^Rd7 , ^Rd8 , ^Rd9 , and ^Rd10 (if present) are H. In certain embodiments, two of ^Rd1 , ^Rd2 , ^Rd3 , ^Rd4 , ^Rd5 , ^Rd6 , ^Rd7 , ^Rd8 , ^Rd9 , and ^Rd10 (if present) are H. In certain embodiments, one of ^Rd1 , ^Rd2 , ^Rd3 , ^Rd4 , ^Rd5 , ^Rd6 , ^Rd7 , ^Rd8 , ^Rd9 , and ^Rd10 (if present) is H.

。在某些實施方式中，R¹是

。 In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

.

In certain embodiments, R ^6a is H. In certain embodiments, R ^6a is phenyl. In certain embodiments, R ^6a is methyl. In certain embodiments, R ^6a is isobutyl. In certain embodiments, R ^6a is t-butyl. In certain embodiments, R ^6a is cyclopropylmethyl. In certain embodiments, R ^6a is cyclobutylmethyl.

In certain embodiments, R ^6a and R ^6b combine with the carbon atom to which they are bonded to form cyclopropyl.

In certain embodiments, R ^6c is C(=O)CF ₃ . In certain embodiments, R ^6c is pyridyl substituted with at least one substituent selected from C ₁ -C ₆ alkyl and halogen. In certain embodiments, R ^6c is pyrazolyl substituted with at least one substituent selected from C ₁ -C ₆ alkyl and halogen. In certain embodiments, R ^6c is phenyl substituted with at least one substituent selected from C ₁ -C ₆ alkyl and halogen.

。在某些實 施方式中，R^6c是

。在某些實施方式中，R^6c是

。在某些實施方式中，R^6c是

。在某些實施方式中，R^6c是

。在某些實施方式中，R^6c是

。 In certain embodiments, R ^6c is C(=O)CF ₃ . In certain embodiments, R ^6c is C(=O)CH ₃ . In certain embodiments, R ^6c is

. In certain embodiments, R ^6c is

. In certain embodiments, R ^6c is

. In certain embodiments, R ^6c is

. In certain embodiments, R ^6c is

. In certain embodiments, R ^6c is

.

In certain embodiments, R ^7a is H. In certain embodiments, R ^7a is cyclopentyl. In certain embodiments, R ^7a is OH. In certain embodiments, R ^7a is Me. In certain embodiments, R ^7a is F.

In certain embodiments, R ^7b is H. In certain embodiments, R ^7b is cyclopentyl. In certain embodiments, R ^7b is OH. In certain embodiments, R ^7b is Me. In certain embodiments, R ^7b is F.

。在某些實施方式中， R³是

。在某些實施方式中，R³是

。在某些實施方式中，R³是

。 In certain embodiments, R ³ is

. In certain embodiments, R ³ is

. In certain embodiments, R ³ is

. In certain embodiments, R ³ is

.

In certain embodiments, L is a bond.

。在某些實施方式中，R^4c是

。在某些實施方式中，R^4c是

。在某些實施方式中，R^4c是

。在某些實施方式中，R^4c是

。在某些實施方式中，R^4c是

。 In certain embodiments, R ^4c is

. In certain embodiments, R ^4c is

. In certain embodiments, R ^4c is

. In certain embodiments, R ^4c is

. In certain embodiments, R ^4c is

. In certain embodiments, R ^4c is

.

In certain embodiments, each of R ^c1 , R ^c2 , R ^c3 , R ^c4 , R ^c5 , R ^c6 , R ^c7 , R ^c8 , R ^c9 , R ^c10 , and R ^c11 (if present) is H. In certain embodiments, ten of R ^c1 , R ^c2 , R ^c3 , R ^c4 , R ^c5 , R ^c6 , R ^c7 , R ^c8 , R ^c9 , R ^c10 , and R ^c11 (if present) are H. In certain embodiments, nine of R ^c1 , R ^c2 , R ^c3 , R ^c4 , R ^c5 , R ^c6 , R ^c7 , R ^c8 , R ^c9 , R ^c10 , and R ^c11 (if present) are H. In certain embodiments, eight of R ^c1 , R ^c2 , R ^c3 , R ^c4 , R ^c5 , R ^c6 , R ^c7 , R ^c8 , R ^c9 , R ^c10 , and R ^c11 (if present) are H. In certain embodiments, seven of R ^c1 , R ^c2 , R ^c3 , R ^c4 , R ^c5 , R ^c6 , R ^c7 , R ^c8 , R ^c9 , R ^c10 , and R ^c11 (if present) are H. In certain embodiments, six of R ^c1 , R ^c2 , R ^c3 , R ^c4 , R ^c5 , R ^c6 , and R ^c7 are H. In certain embodiments, five of R ^c1 , R ^c2 , R ^c3 , R ^c4 , R ^c5 , R ^c6 , R ^c7 , R ^c8 , R ^c9 , R ^c10 , and R ^c11 (if present) are H. In certain embodiments, four of R ^c1 , R ^c2 , R ^c3 , R ^c4 , R ^c5 , R ^c6 , R ^c7 , R ^c8 , R ^c9 , R ^c10 , and R ^c11 (if present) are H. In certain embodiments, three of R ^c1 , R ^c2 , R ^c3 , R ^c4 , R ^c5 , R ^c6 , R ^c7 , R ^c8 , R ^c9 , R ^c10 , and R ^c11 (if present) are H. In certain embodiments, two of R ^c1 , R ^c2 , R ^c3 , R ^c4 , R ^c5 , R ^c6 , R ^c7 , R ^c8 , R ^c9 , R ^c10 , and R ^c11 (if present) are H. In certain embodiments, one of R ^c1 , R ^c2 , R ^c3 , R ^c4 , R ^c5 , R ^c6 , R ^c7 , R ^c8 , R ^c9 , R ^c10 and R ^c11 (if present) is H.

。在某些實施方式中，R¹是

。在某些實施方式中，R¹是

。在某些實施方式中，R¹是

。在某些實施方式中，R¹是

。在某些實施 方式中，R¹是

。在某些實施方式中，R¹是

。在某些實施方式中，R¹是

。在某些實施方式中，R¹是

。在某些實施方式中，R¹是

。在某些實施方式中，R¹是

。在某些實施方式中，R¹是

。在某些實施方式中，R¹是

。在某些實施方式中，R¹是

。在某些實施方式中，R¹是

。在某些實施方式中，R¹是

。在某些實施 方式中，R¹是

。在某些實施方式中，R¹是

。在某些實施方式中，R¹是

。在某些實施方式中，R¹是

。在某些實施方式中，R¹是

。在某些實施方式中，R¹是

。在某些實施方式中，R¹是

。在某些實施方式中，R¹是

。在某些實施方式中，R¹是

。在某些實施方式中，R¹是

。在某些實施方式中，R¹是

。在某些實施方式中，R¹是

。在某些實施方式中，R¹是

。在某些實施方式中，R¹是

。在某些實施方式中，R¹是

。在某些實施方式中，R¹是

。在某些實施方式中，R¹是

。 在某些實施方式中，R¹是

。在某些實施方式中，R¹是

。在某些實施方式中，R¹是

。在某些實施方式中，R¹是

。在某些實施方式中，R¹是

。在某些實施方式中， R¹是

。在某些實施方式中，R¹是

。在某些實施方式中，R¹是

。在某些實施方式中，R¹是

。在某些實施方 式中，R¹是

。在某些實施方式中，R¹是

。在某些實 施方式中，R¹是

。在某些實施方式中，R¹是

。在某些實施方式中，R¹是

。在某些實施方式中，R¹是

。在某些實施方式中，R¹是

。在某些實施方式 中，R¹是

。在某些實施方式中，R¹是

。在某些實施方式中，R¹是

。在某些實施方式中，R¹是

。在某些實施方式中，R¹是

。在某些實施方式中，R¹是

。在某些實施方式中，R¹是

。在某些實施方式中，R¹是

。在某些實施方式中，R¹是

。在某些實施方式中，R¹是

。在某些實施方式中，R¹是

。在某些實施方式中，R¹是

。 In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

. In certain embodiments, R ¹ is

.

In certain embodiments, R ^2a is methyl. In certain embodiments, R ^2a is ethyl. In certain embodiments, R ^2a is n-propyl. In certain embodiments, R ^2a is isopropyl. In certain embodiments, R ^2a is cyclopropyl. In certain embodiments, R ^2a is cyclopropylmethyl. In certain embodiments, R ^2a is n-butyl. In certain embodiments, R ^2a is second-butyl. In certain embodiments, R ^2a is t-butyl. In certain embodiments, R ^2a is cyclobutyl. In certain embodiments, R ^2a is methylcyclobutyl. In certain embodiments, R ^2a is n-pentyl. In certain embodiments, R ^2a is second pentyl. In certain embodiments, R ^2a is third amyl. In certain embodiments, R ^2a is neopentyl. In certain embodiments, R ^2a is cyclopentyl. In certain embodiments, R ^2a is cyclopentylmethyl. In certain embodiments, R ^2a is n-hexyl. In certain embodiments, R ^2a is second hexyl. In certain embodiments, R ^2a is third hexyl. In certain embodiments, R ^2a is neohexyl. In certain embodiments, R ^2a is cyclohexyl. In certain embodiments, R ^2a is cyclohexylmethyl.

In certain embodiments, R ^2b is methyl. In certain embodiments, R ^2b is ethyl. In certain embodiments, R ^2b is n-propyl. In certain embodiments, R ^2b is isopropyl. In certain embodiments, R ^2b is cyclopropyl. In certain embodiments, R ^2b is cyclopropylmethyl. In certain embodiments, R ^2b is n-butyl. In certain embodiments, R ^2b is second butyl. In certain embodiments, R ^2b is t-butyl. In certain embodiments, R ^2b is cyclobutyl. In certain embodiments, R ^2b is methylcyclobutyl. In certain embodiments, R ^2b is n-pentyl. In certain embodiments, R ^2b is a second pentyl. In certain embodiments, R ^2b is third amyl. In certain embodiments, R ^2b is neopentyl. In certain embodiments, R ^2b is cyclopentyl. In certain embodiments, R ^2b is cyclopentylmethyl. In certain embodiments, R ^2b is n-hexyl. In certain embodiments, R ^2b is second hexyl. In certain embodiments, R ^2b is third hexyl. In certain embodiments, R ^2b is neohexyl. In certain embodiments, R ^2b is cyclohexyl. In certain embodiments, R ^2b is cyclohexylmethyl.

In certain embodiments, one of R ^2a and R ^2b is H.

In certain embodiments, each of R ^b1 , R ^b2 and R ^b3 (if present) is H. In certain embodiments, two of R ^b1 , R ^b2 and R ^b3 (if present) are H. In certain embodiments, one of R ^b1 , R ^b2 and R ^b3 (if present) is H.

。在某些實施方式中，R^4a是

。在某些實施方式中，R^4a是

。在某些實施方式中，R^4a是

。在某些實施方式中，R^4a是

。在某些實施方式中，R^4a是

。在某些實施方式中，R^4a是

。在某些實施方式中，R^4a是

。在某些實施方式中，R^4a是

。在某些實施方式中，R^4a是

。在某些實施方式中，R^4a是

。在某些實施方式中，R^4a是

。 In certain embodiments, R ^4a is CN. In certain embodiments, R ^4a is CHO. In certain embodiments, R ^4a is

. In certain embodiments, R ^4a is

. In certain embodiments, R ^4a is

. In certain embodiments, R ^4a is

. In certain embodiments, R ^4a is

. In certain embodiments, R ^4a is

. In certain embodiments, R ^4a is

. In certain embodiments, R ^4a is

. In certain embodiments, R ^4a is

. In certain embodiments, R ^4a is

. In certain embodiments, R ^4a is

. In certain embodiments, R ^4a is

.

。在某些實施方式中，R^4c是

。在某些實施方式中，R^4c是

。在某些實施方式中，R^4c是

。在某些實施方式中，R^4c是

。在某些實施方式中，R^4c是

。 In certain embodiments, R ^4c is

. In certain embodiments, R ^4c is

. In certain embodiments, R ^4c is

. In certain embodiments, R ^4c is

. In certain embodiments, R ^4c is

. In certain embodiments, R ^4c is

.

。在某些實施方式中，R³是

。在某些實施方式中，R³是

。在某些實施方式中，R³是

。在某些實施方式中，R³是

。在某些實施方式中，R³是

。在某些實施方式中，R³是

。在某些實施方式中，R³是

。在某些實施方式中，R³是

。在某些 實施方式中，R³是

。在某些實施方式中，R³是

。在某些實施方式中，R³是

。在某些實施方式中，R³是

。在某些實施方式中，R³是

。在某些實施方式中，R³是

。在某些實施方式中，R³是

。在某些實施方式中，R³是

。在某些實施方式中，R³是

。在某些實施方式中，R³是

。在某些實施方式中，R³是

。 In certain embodiments, R ³ is

. In certain embodiments, R ³ is

. In certain embodiments, R ³ is

. In certain embodiments, R ³ is

. In certain embodiments, R ³ is

. In certain embodiments, R ³ is

. In certain embodiments, R ³ is

. In certain embodiments, R ³ is

. In certain embodiments, R ³ is

. In certain embodiments, R ³ is

. In certain embodiments, R ³ is

. In certain embodiments, R ³ is

. In certain embodiments, R ³ is

. In certain embodiments, R ³ is

. In certain embodiments, R ³ is

. In certain embodiments, R ³ is

. In certain embodiments, R ³ is

. In certain embodiments, R ³ is

. In certain embodiments, R ³ is

. In certain embodiments, R ³ is

.

In certain embodiments, each occurrence of optionally substituted alkyl, optionally substituted cycloalkyl, and optionally substituted heterocycloalkyl is independently optionally substituted with at least one selected from : C ₁ -C ₆ alkyl, C ₃ -C ₈ cycloalkyl, C ₁ -C ₆ hydroxyalkyl, halogen, CN, OR ^I , N(R ^I )(R ^II ), C ₁ -C ₆ alkane Oxygen, C ₃ -C ₈ cycloalkoxy, C ₁ -C ₆ haloalkoxy, C ₃ -C ₈ halocycloalkoxy, optionally substituted phenyl, optionally substituted C ₂ - C ₉ Heteroaryl, C(=O)R ^I , C(=O)OR ^I , OC(=O)R ^I , OC(=O)OR ^I , SR ^I , S(=O)R ^I , S (=O) ₂ R ^I , S(=O) ₂ N(R ^I )(R ^II ), S(=O) ₂ NR ^I C(=O)NHR ^II , N(R ^I )S(=O) ₂ R ^II , N(R ^I )C(=O)R ^II and C(=O)NR ^I R ^II , wherein R ^I and R ^II are each independently selected from H, -C(=O)(C ₁ - C ₆ alkyl), -C(=O)(C ₁ -C ₆ haloalkyl), C ₁ -C ₆ alkyl, C ₁ -C ₃ haloalkyl, C ₃ -C ₈ cycloalkyl, C ₁ - C ₆ alkoxy and C ₃ -C ₈ cycloalkoxy, phenyl, naphthyl and C ₂ -C ₉ heteroaryl.

In certain embodiments, each occurrence of optionally substituted phenyl, optionally substituted naphthyl, optionally substituted heterocyclyl, and optionally substituted heteroaryl is independently optionally substituted by Substituted by at least one substituent selected from the following: C ₁ -C ₆ alkyl, C ₃ -C ₈ cycloalkyl, phenyl, C ₁ -C ₆ hydroxyalkyl, C ₁ -C ₆ alkoxy, C ₃ -C ₈ cycloalkoxy, C ₁ -C ₆ haloalkoxy, C ₁ -C ₆ haloalkoxy, C ₃ -C ₈ halocycloalkoxy, halogen, CN, OR ^I , N(R ^I ) ( R ^II ), NO ₂ , C(=O)N(R ^I )(R ^II ), C(=O)R ^I , C(=O)OR ^I , OC(=O)R ^I , OC(=O )OR ^I , SR ^I , S(=O)R ^I , S(=O) ₂ R ^I , N(R ^I )S(=O) ₂ R ^II , N(R ^I )C(=O)R ^II and S(=O) ₂ N(R ^I )(R ^II ), wherein R ^I and R ^II are each independently selected from H, -C(=O)(C ₁ -C ₆ alkyl), -C(= O)(C ₁ -C ₆ haloalkyl), C ₁ -C ₆ alkyl, C ₁ -C ₃ haloalkyl, C ₃ -C ₈ cycloalkyl, C ₁ -C ₆ alkoxy and C ₃ -C ₈ cycloalkoxy, phenyl, naphthyl and C ₂ -C ₉ heteroaryl.

In certain embodiments, the compound is selected from:

N-(3-cyclohexyl-1-oxo-1-((1-oxo-3-(2-oxopyrrolidin-3-yl)propan-2-yl)amino)propane-2 -yl)-9-hydroxyl-9H-stilbene-9-formamide;

N-((S)-3-cyclohexyl-1-oxo-1-(((S)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl) Propan-2-yl)amino)propan-2-yl)-9-hydroxyl-9H-tila-9-carboxamide;

N-((S)-3-cyclohexyl-1-oxo-1-(((S)-1-oxo-3-((R)-2-oxopyrrolidin-3-yl) Propan-2-yl)amino)propan-2-yl)-9-hydroxyl-9H-tila-9-carboxamide;

N-((S)-3-cyclohexyl-1-oxo-1-(((R)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl) Propan-2-yl)amino)propan-2-yl)-9-hydroxyl-9H-tila-9-carboxamide;

N-((S)-3-cyclohexyl-1-oxo-1-(((R)-1-oxo-3-((R)-2-oxopyrrolidin-3-yl) Propan-2-yl)amino)propan-2-yl)-9-hydroxyl-9H-tila-9-carboxamide;

N-((R)-3-cyclohexyl-1-oxo-1-(((S)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl) Propan-2-yl)amino)propan-2-yl)-9-hydroxyl-9H-tila-9-carboxamide;

N-((R)-3-cyclohexyl-1-oxo-1-(((S)-1-oxo-3-((R)-2-oxopyrrolidin-3-yl) Propan-2-yl)amino)propan-2-yl)-9-hydroxyl-9H-tila-9-carboxamide;

N-((R)-3-cyclohexyl-1-oxo-1-(((R)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl) Propan-2-yl)amino)propan-2-yl)-9-hydroxyl-9H-tila-9-carboxamide;

N-((R)-3-cyclohexyl-1-oxo-1-(((R)-1-oxo-3-((R)-2-oxopyrrolidin-3-yl) Propan-2-yl)amino)propan-2-yl)-9-hydroxyl-9H-tila-9-carboxamide;

N-(4-(cyclopropylamino)-3,4-dioxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)-2-(2-hydroxyl-2 , 2-diphenylacetamido)-4-methylpentanamide;

(S)-N-((S)-4-(cyclopropylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2 -yl)-2-(2-hydroxy-2,2-diphenylacetamido)-4-methylpentanamide;

(S)-N-((S)-4-(cyclopropylamino)-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2 -yl)-2-(2-hydroxy-2,2-diphenylacetamido)-4-methylpentanamide;

(S)-N-((R)-4-(cyclopropylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2 -yl)-2-(2-hydroxy-2,2-diphenylacetamido)-4-methylpentanamide;

(S)-N-((R)-4-(cyclopropylamino)-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2 -yl)-2-(2-hydroxy-2,2-diphenylacetamido)-4-methylpentanamide;

(R)-N-((S)-4-(cyclopropylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2 -yl)-2-(2-hydroxy-2,2-diphenylacetamido)-4-methylpentanamide;

(R)-N-((S)-4-(cyclopropylamino)-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2 -yl)-2-(2-hydroxy-2,2-diphenylacetamido)-4-methylpentanamide;

(R)-N-((R)-4-(cyclopropylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2 -yl)-2-(2-hydroxy-2,2-diphenylacetamido)-4-methylpentanamide;

(R)-N-((R)-4-(cyclopropylamino)-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2 -yl)-2-(2-hydroxy-2,2-diphenylacetamido)-4-methylpentanamide;

N-(3-cyclohexyl-1-((4-hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)amino)-1-oxo Propan-2-yl)-9-hydroxyl-9H-oxo-9-carboxamide;

N-((S)-3-cyclohexyl-1-(((S)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-formamide;

N-((S)-3-cyclohexyl-1-(((S)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-formamide;

N-((S)-3-cyclohexyl-1-(((R)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-formamide;

N-((S)-3-cyclohexyl-1-(((R)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-formamide;

N-((R)-3-cyclohexyl-1-(((S)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-formamide;

N-((R)-3-cyclohexyl-1-(((S)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-formamide;

N-((R)-3-cyclohexyl-1-(((R)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-formamide;

N-((R)-3-cyclohexyl-1-(((R)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-formamide;

-2-甲醯胺； N-(4-Hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)-1-(9-hydroxy-9H-oxo-9-carbonyl) -4-Phenylpiperidine

-2-Formamide;

-2-甲醯胺； (S)-N-((S)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-1-( 9-Hydroxy-9H-terpinene-9-carbonyl)-4-phenylpiperene

-2-Formamide;

-2-甲醯胺； (S)-N-((S)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-1-( 9-Hydroxy-9H-terpinene-9-carbonyl)-4-phenylpiperene

-2-Formamide;

-2-甲醯胺； (S)-N-((R)-4-hydroxyl-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-1-( 9-Hydroxy-9H-terpinene-9-carbonyl)-4-phenylpiperene

-2-Formamide;

-2-甲醯胺； (S)-N-((R)-4-hydroxyl-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-1-( 9-Hydroxy-9H-terpinene-9-carbonyl)-4-phenylpiperene

-2-Formamide;

-2-甲醯胺； (R)-N-((S)-4-hydroxyl-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-1-( 9-Hydroxy-9H-terpinene-9-carbonyl)-4-phenylpiperene

-2-Formamide;

-2-甲醯胺； (R)-N-((S)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-1-( 9-Hydroxy-9H-terpinene-9-carbonyl)-4-phenylpiperene

-2-Formamide;

-2-甲醯胺； (R)-N-((R)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-1-( 9-Hydroxy-9H-terpinene-9-carbonyl)-4-phenylpiperene

-2-Formamide;

-2-甲醯胺； (R)-N-((R)-4-hydroxyl-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-1-( 9-Hydroxy-9H-terpinene-9-carbonyl)-4-phenylpiperene

-2-Formamide;

9-Hydroxy-N-(4-methyl-1-((4-(methylamino)-3,4-dioxo-1-(2-oxopyrrolidin-3-yl)butane-2- Base) amino)-1-oxopentan-2-yl)-9H-stilbene-9-carboxamide;

9-Hydroxy-N-((S)-4-methyl-1-(((S)-4-(methylamino)-3,4-dioxo-1-((S)-2-oxo Pyrrolidin-3-yl)butan-2-yl)amino)-1-oxopentan-2-yl)-9H-oxo-9-carboxamide;

9-Hydroxy-N-((S)-4-methyl-1-(((S)-4-(methylamino)-3,4-dioxo-1-((R)-2-oxo Pyrrolidin-3-yl)butan-2-yl)amino)-1-oxopentan-2-yl)-9H-oxo-9-carboxamide;

9-Hydroxy-N-((S)-4-methyl-1-(((R)-4-(methylamino)-3,4-dioxo-1-((S)-2-oxo Pyrrolidin-3-yl)butan-2-yl)amino)-1-oxopentan-2-yl)-9H-oxo-9-carboxamide;

9-Hydroxy-N-((S)-4-methyl-1-(((R)-4-(methylamino)-3,4-dioxo-1-((R)-2-oxo Pyrrolidin-3-yl)butan-2-yl)amino)-1-oxopentan-2-yl)-9H-oxo-9-carboxamide;

9-Hydroxy-N-((R)-4-methyl-1-(((S)-4-(methylamino)-3,4-dioxo-1-((S)-2-oxo Pyrrolidin-3-yl)butan-2-yl)amino)-1-oxopentan-2-yl)-9H-oxo-9-carboxamide;

9-Hydroxy-N-((R)-4-methyl-1-(((S)-4-(methylamino)-3,4-dioxo-1-((R)-2-oxo Pyrrolidin-3-yl)butan-2-yl)amino)-1-oxopentan-2-yl)-9H-oxo-9-carboxamide;

9-Hydroxy-N-((R)-4-methyl-1-(((R)-4-(methylamino)-3,4-dioxo-1-((S)-2-oxo Pyrrolidin-3-yl)butan-2-yl)amino)-1-oxopentan-2-yl)-9H-oxo-9-carboxamide;

9-Hydroxy-N-((R)-4-methyl-1-(((R)-4-(methylamino)-3,4-dioxo-1-((R)-2-oxo Pyrrolidin-3-yl)butan-2-yl)amino)-1-oxopentan-2-yl)-9H-oxo-9-carboxamide;

N-(1-((4-(ethylamino)-3,4-dioxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)amino)-4-methanol Base-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((S)-1-(((S)-4-(ethylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-formamide;

N-((S)-1-(((S)-4-(ethylamino)-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-formamide;

N-((S)-1-(((R)-4-(ethylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-formamide;

N-((S)-1-(((R)-4-(ethylamino)-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-formamide;

N-((R)-1-(((S)-4-(ethylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-formamide;

N-((R)-1-(((S)-4-(ethylamino)-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-formamide;

N-((R)-1-(((R)-4-(ethylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-formamide;

N-((R)-1-(((R)-4-(ethylamino)-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-formamide;

N-(1-((1-(4-chlorothiazol-2-yl)-1-oxo-3-(2-oxopyrrolidin-3-yl)propan-2-yl)amino)- 4-Methyl-1-oxopentan-2-yl)-4-methoxy-1H-indole-2-carboxamide;

N-((S)-1-(((S)-1-(4-chlorothiazol-2-yl)-1-oxo-3-((S)-2-oxopyrrolidine-3- Base) propan-2-yl) amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1H-indole-2-carboxamide;

N-((S)-1-(((S)-1-(4-chlorothiazol-2-yl)-1-oxo-3-((R)-2-oxopyrrolidine-3- Base) propan-2-yl) amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1H-indole-2-carboxamide;

N-((S)-1-(((R)-1-(4-chlorothiazol-2-yl)-1-oxo-3-((S)-2-oxopyrrolidine-3- Base) propan-2-yl) amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1H-indole-2-carboxamide;

N-((S)-1-(((R)-1-(4-chlorothiazol-2-yl)-1-oxo-3-((R)-2-oxopyrrolidine-3- Base) propan-2-yl) amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1H-indole-2-carboxamide;

N-((R)-1-(((S)-1-(4-chlorothiazol-2-yl)-1-oxo-3-((S)-2-oxopyrrolidine-3- Base) propan-2-yl) amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1H-indole-2-carboxamide;

N-((R)-1-(((S)-1-(4-chlorothiazol-2-yl)-1-oxo-3-((R)-2-oxopyrrolidine-3- Base) propan-2-yl) amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1H-indole-2-carboxamide;

N-((R)-1-(((R)-1-(4-chlorothiazol-2-yl)-1-oxo-3-((S)-2-oxopyrrolidine-3- Base) propan-2-yl) amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1H-indole-2-carboxamide;

N-((R)-1-(((R)-1-(4-chlorothiazol-2-yl)-1-oxo-3-((R)-2-oxopyrrolidine-3- Base) propan-2-yl) amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1H-indole-2-carboxamide;

N-(3-cyclohexyl-1-((4-(methylamino)-3,4-dioxo-1-(2-oxopyrrolidin-3-yl)butan-2-yl)amino )-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((S)-3-cyclohexyl-1-(((S)-4-(methylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidine-3 -yl)butane-2-yl)amino)-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((S)-3-cyclohexyl-1-(((S)-4-(methylamino)-3,4-dioxo-1-((R)-2-oxopyrrolidine-3 -yl)butane-2-yl)amino)-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((S)-3-cyclohexyl-1-(((R)-4-(methylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidine-3 -yl)butane-2-yl)amino)-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((S)-3-cyclohexyl-1-(((R)-4-(methylamino)-3,4-dioxo-1-((R)-2-oxopyrrolidine-3 -yl)butane-2-yl)amino)-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((R)-3-cyclohexyl-1-(((S)-4-(methylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidine-3 -yl)butane-2-yl)amino)-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((R)-3-cyclohexyl-1-(((S)-4-(methylamino)-3,4-dioxo-1-((R)-2-oxopyrrolidine-3 -yl)butane-2-yl)amino)-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((R)-3-cyclohexyl-1-(((R)-4-(methylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidine-3 -yl)butane-2-yl)amino)-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((R)-3-cyclohexyl-1-(((R)-4-(methylamino)-3,4-dioxo-1-((R)-2-oxopyrrolidine-3 -yl)butane-2-yl)amino)-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-(1-((4-amino-3,4-dioxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)amino)-3-cyclohexyl-1 -Oxopropan-2-yl)-9-hydroxy-9H-oxo-9-carboxamide;

N-((S)-1-(((S)-4-amino-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2- Base) amino)-3-cyclohexyl-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((S)-1-(((S)-4-amino-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2- Base) amino)-3-cyclohexyl-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((S)-1-(((R)-4-amino-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2- Base) amino)-3-cyclohexyl-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((S)-1-(((R)-4-amino-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2- Base) amino)-3-cyclohexyl-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((R)-1-(((S)-4-amino-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2- Base) amino)-3-cyclohexyl-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((R)-1-(((S)-4-amino-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2- Base) amino)-3-cyclohexyl-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((R)-1-(((R)-4-amino-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2- Base) amino)-3-cyclohexyl-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((R)-1-(((R)-4-amino-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2- Base) amino)-3-cyclohexyl-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-(1-((4-(cyclopropylamino)-3,4-dioxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)amino)-4 -Methyl-1-oxopentan-2-yl)-9-hydroxy-9H-stilbene-9-carboxamide;

N-((S)-1-(((S)-4-(cyclopropylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl) Butane-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((S)-1-(((S)-4-(cyclopropylamino)-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl) Butane-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((S)-1-(((R)-4-(cyclopropylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl) Butane-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((S)-1-(((R)-4-(cyclopropylamino)-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl) Butane-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((R)-1-(((S)-4-(cyclopropylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl) Butane-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((R)-1-(((S)-4-(cyclopropylamino)-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl) Butane-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((R)-1-(((R)-4-(cyclopropylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl) Butane-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((R)-1-(((R)-4-(cyclopropylamino)-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl) Butane-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

(3aR,6aS)-N-(4-Hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)-2-(4-methoxy- 1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(3aS,6aR)-N-(4-Hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)-2-(4-methoxy- 1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

N-(1-((4-amino-3,4-dioxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)amino)-4-methyl-1 -Oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((S)-1-(((S)-4-amino-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2- Base) amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((S)-1-(((S)-4-amino-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2- Base) amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((S)-1-(((R)-4-amino-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2- Base) amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((S)-1-(((R)-4-amino-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2- Base) amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((R)-1-(((S)-4-amino-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2- Base) amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((R)-1-(((S)-4-amino-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2- Base) amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((R)-1-(((R)-4-amino-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2- Base) amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((R)-1-(((R)-4-amino-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2- Base) amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-(1-((1-(4-chlorothiazol-2-yl)-1-oxo-3-(2-oxopyrrolidin-3-yl)propan-2-yl)amino)- 3-cyclohexyl-1-oxopropan-2-yl)-4-methoxy-1H-indole-2-carboxamide;

N-((S)-1-(((S)-1-(4-chlorothiazol-2-yl)-1-oxo-3-((S)-2-oxopyrrolidine-3- Base) propan-2-yl) amino)-3-cyclohexyl-1-oxopropan-2-yl)-4-methoxy-1H-indole-2-carboxamide;

N-((S)-1-(((S)-1-(4-chlorothiazol-2-yl)-1-oxo-3-((R)-2-oxopyrrolidine-3- Base) propan-2-yl) amino)-3-cyclohexyl-1-oxopropan-2-yl)-4-methoxy-1H-indole-2-carboxamide;

N-((S)-1-(((R)-1-(4-chlorothiazol-2-yl)-1-oxo-3-((S)-2-oxopyrrolidine-3- Base) propan-2-yl) amino)-3-cyclohexyl-1-oxopropan-2-yl)-4-methoxy-1H-indole-2-carboxamide;

N-((S)-1-(((R)-1-(4-chlorothiazol-2-yl)-1-oxo-3-((R)-2-oxopyrrolidine-3- Base) propan-2-yl) amino)-3-cyclohexyl-1-oxopropan-2-yl)-4-methoxy-1H-indole-2-carboxamide;

N-((R)-1-(((S)-1-(4-chlorothiazol-2-yl)-1-oxo-3-((S)-2-oxopyrrolidine-3- Base) propan-2-yl) amino)-3-cyclohexyl-1-oxopropan-2-yl)-4-methoxy-1H-indole-2-carboxamide;

N-((R)-1-(((S)-1-(4-chlorothiazol-2-yl)-1-oxo-3-((R)-2-oxopyrrolidine-3- Base) propan-2-yl) amino)-3-cyclohexyl-1-oxopropan-2-yl)-4-methoxy-1H-indole-2-carboxamide;

N-((R)-1-(((R)-1-(4-chlorothiazol-2-yl)-1-oxo-3-((S)-2-oxopyrrolidine-3- Base) propan-2-yl) amino)-3-cyclohexyl-1-oxopropan-2-yl)-4-methoxy-1H-indole-2-carboxamide;

N-((R)-1-(((R)-1-(4-chlorothiazol-2-yl)-1-oxo-3-((R)-2-oxopyrrolidine-3- Base) propan-2-yl) amino)-3-cyclohexyl-1-oxopropan-2-yl)-4-methoxy-1H-indole-2-carboxamide;

(3aR,6aS)-N-(4-hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)-2-(9-hydroxyl-9H- Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(3aS,6aR)-N-(4-hydroxyl-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)-2-(9-hydroxyl-9H- Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

9-Hydroxy-N-(1-((4-hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)amino)-4,4- Dimethyl-1-oxopentan-2-yl)-9H-oxo-9-formamide;

9-Hydroxy-N-((S)-1-(((S)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane- 2-yl)amino)-4,4-dimethyl-1-oxopentan-2-yl)-9H-stilbene-9-carboxamide;

9-Hydroxy-N-((S)-1-(((S)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane- 2-yl)amino)-4,4-dimethyl-1-oxopentan-2-yl)-9H-stilbene-9-carboxamide;

9-Hydroxy-N-((S)-1-(((R)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane- 2-yl)amino)-4,4-dimethyl-1-oxopentan-2-yl)-9H-stilbene-9-carboxamide;

9-Hydroxy-N-((S)-1-(((R)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane- 2-yl)amino)-4,4-dimethyl-1-oxopentan-2-yl)-9H-stilbene-9-carboxamide;

9-Hydroxy-N-((R)-1-(((S)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane- 2-yl)amino)-4,4-dimethyl-1-oxopentan-2-yl)-9H-stilbene-9-carboxamide;

9-Hydroxy-N-((R)-1-(((S)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane- 2-yl)amino)-4,4-dimethyl-1-oxopentan-2-yl)-9H-stilbene-9-carboxamide;

9-Hydroxy-N-((R)-1-(((R)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane- 2-yl)amino)-4,4-dimethyl-1-oxopentan-2-yl)-9H-stilbene-9-carboxamide;

9-Hydroxy-N-((R)-1-(((R)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane- 2-yl)amino)-4,4-dimethyl-1-oxopentan-2-yl)-9H-stilbene-9-carboxamide;

N-(3-cyclohexyl-1-((4-hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)amino)-1-oxo Propan-2-yl)-9-(2,2,2-trifluoroacetamido)-9H-stilbene-9-carboxamide;

N-((S)-3-cyclohexyl-1-(((S)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-1-oxopropan-2-yl)-9-(2,2,2-trifluoroacetamido)-9H-oxo-9-formamide;

N-((S)-3-cyclohexyl-1-(((S)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-1-oxopropan-2-yl)-9-(2,2,2-trifluoroacetamido)-9H-oxo-9-formamide;

N-((S)-3-cyclohexyl-1-(((R)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-1-oxopropan-2-yl)-9-(2,2,2-trifluoroacetamido)-9H-oxo-9-formamide;

N-((S)-3-cyclohexyl-1-(((R)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-1-oxopropan-2-yl)-9-(2,2,2-trifluoroacetamido)-9H-oxo-9-formamide;

N-((R)-3-cyclohexyl-1-(((S)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-1-oxopropan-2-yl)-9-(2,2,2-trifluoroacetamido)-9H-oxo-9-formamide;

N-((R)-3-cyclohexyl-1-(((S)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-1-oxopropan-2-yl)-9-(2,2,2-trifluoroacetamido)-9H-oxo-9-formamide;

N-((R)-3-cyclohexyl-1-(((R)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-1-oxopropan-2-yl)-9-(2,2,2-trifluoroacetamido)-9H-oxo-9-formamide;

N-((R)-3-cyclohexyl-1-(((R)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-1-oxopropan-2-yl)-9-(2,2,2-trifluoroacetamido)-9H-oxo-9-formamide;

N-(4-Hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)-2-(9-hydroxy-9H-oxo-9-carbonyl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((S)-4-hydroxyl-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 9-Hydroxy-9H-Oxane-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((S)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 9-Hydroxy-9H-Oxane-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((R)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 9-Hydroxy-9H-Oxane-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((R)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 9-Hydroxy-9H-Oxane-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((S)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 9-Hydroxy-9H-Oxane-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((S)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 9-Hydroxy-9H-Oxane-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((R)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 9-Hydroxy-9H-Oxane-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((R)-4-hydroxyl-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 9-Hydroxy-9H-Oxane-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

N-(1-((4-hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)amino)-4-methyl-1-oxo Pentane-2-yl)-4-methoxy-1-propyl-1H-indole-2-carboxamide;

N-((S)-1-(((S)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) Amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1-propyl-1H-indole-2-carboxamide;

N-((S)-1-(((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) Amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1-propyl-1H-indole-2-carboxamide;

N-((S)-1-(((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) Amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1-propyl-1H-indole-2-carboxamide;

N-((S)-1-(((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) Amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1-propyl-1H-indole-2-carboxamide;

N-((R)-1-(((S)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) Amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1-propyl-1H-indole-2-carboxamide;

N-((R)-1-(((S)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) Amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1-propyl-1H-indole-2-carboxamide;

N-((R)-1-(((R)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) Amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1-propyl-1H-indole-2-carboxamide;

N-((R)-1-(((R)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) Amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1-propyl-1H-indole-2-carboxamide;

(3aR,6aS)-N-(4-Hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)-2-(1H-indole-2 -carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(3aS,6aR)-N-(4-Hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)-2-(1H-indole-2 -carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-(1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-(1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-(1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-(1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-(1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

N-(1-((4-hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)amino)-4-methyl-1-oxo Pentan-2-yl)-4-methoxy-1-(2-methylallyl)-1H-indole-2-carboxamide;

N-((S)-1-(((S)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) Amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1-(2-methylallyl)-1H-indole-2-carboxamide;

N-((S)-1-(((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) Amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1-(2-methylallyl)-1H-indole-2-carboxamide;

N-((S)-1-(((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) Amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1-(2-methylallyl)-1H-indole-2-carboxamide;

N-((S)-1-(((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) Amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1-(2-methylallyl)-1H-indole-2-carboxamide;

N-((R)-1-(((S)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) Amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1-(2-methylallyl)-1H-indole-2-carboxamide;

N-((R)-1-(((S)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) Amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1-(2-methylallyl)-1H-indole-2-carboxamide;

N-((R)-1-(((R)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) Amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1-(2-methylallyl)-1H-indole-2-carboxamide;

N-((R)-1-(((R)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) Amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1-(2-methylallyl)-1H-indole-2-carboxamide;

N -(1-cyano-2-(2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-(9-hydroxy-9H-fennel-9-carbonyl)-2 - azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

2-(2-(3-Chlorophenyl)-2-hydroxyacetyl) -N- (1-cyano-2-(2-oxopyrrolidin-3-yl)ethyl)-5,5 - Difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )-2-(( S )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( S )-1-cyano-2- (( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )-2-(( S )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( S )-1-cyano-2- (( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )-2-(( S )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( S )-1-cyano-2- (( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )-2-(( S )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( S )-1-cyano-2- (( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )-2-(( R )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( S )-1-cyano-2- (( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )-2-(( R )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( S )-1-cyano-2- (( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )-2-(( R )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( S )-1-cyano-2- (( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )-2-(( R )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( S )-1-cyano-2- (( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )-2-(( S )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( R )-1-cyano-2- (( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )-2-(( S )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( R )-1-cyano-2- (( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )-2-(( S )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( R )-1-cyano-2- (( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )-2-(( S )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( R )-1-cyano-2- (( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )-2-(( R )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( R )-1-cyano-2- (( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )-2-(( R )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( R )-1-cyano-2- (( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )-2-(( R )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( R )-1-cyano-2- (( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )-2-(( R )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( R )-1-cyano-2- (( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )-2-(( S )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( S )-1-cyano-2- (( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 S ,3 R ,4 S )-2-(( S )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( S )-1-cyano-2- (( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 R ,3 S ,4 R )-2-(( S )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( S )-1-cyano-2- (( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 R ,3 R ,4 R )-2-(( S )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( S )-1-cyano-2- (( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 S ,3 S ,4 S )-2-(( R )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( S )-1-cyano-2- (( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 S ,3 R ,4 S )-2-(( R )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( S )-1-cyano-2- (( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 R ,3 S ,4 R )-2-(( R )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( S )-1-cyano-2- (( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 R ,3 R ,4 R )-2-(( R )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( S )-1-cyano-2- (( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 S ,3 S ,4 S )-2-(( S )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( R )-1-cyano-2- (( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 S ,3 R ,4 S )-2-(( S )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( R )-1-cyano-2- (( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 R ,3 S ,4 R )-2-(( S )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( R )-1-cyano-2- (( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 R ,3 R ,4 R )-2-(( S )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( R )-1-cyano-2- (( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 S ,3 S ,4 S )-2-(( R )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( R )-1-cyano-2- (( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 S ,3 R ,4 S )-2-(( R )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( R )-1-cyano-2- (( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 R ,3 S ,4 R )-2-(( R )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( R )-1-cyano-2- (( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 R ,3 R ,4 R )-2-(( R )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( R )-1-cyano-2- (( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

N -[1-cyano-2-[2-oxopyrrolidin-3-yl]ethyl]-2-[2-(3,5-dichlorophenyl)-2,2-difluoro-ethyl Acyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ 2-(3,5-Dichlorophenyl)-2,2-difluoro-acetyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ 2-(3,5-Dichlorophenyl)-2,2-difluoro-acetyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ 2-(3,5-Dichlorophenyl)-2,2-difluoro-acetyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ 2-(3,5-Dichlorophenyl)-2,2-difluoro-acetyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ 2-(3,5-Dichlorophenyl)-2,2-difluoro-acetyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ 2-(3,5-Dichlorophenyl)-2,2-difluoro-acetyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1 R ,3 S ,4 R )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ 2-(3,5-Dichlorophenyl)-2,2-difluoro-acetyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1 R ,3 R ,4 R )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ 2-(3,5-Dichlorophenyl)-2,2-difluoro-acetyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ 2-(3,5-Dichlorophenyl)-2,2-difluoro-acetyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ 2-(3,5-Dichlorophenyl)-2,2-difluoro-acetyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ 2-(3,5-Dichlorophenyl)-2,2-difluoro-acetyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ 2-(3,5-Dichlorophenyl)-2,2-difluoro-acetyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ 2-(3,5-Dichlorophenyl)-2,2-difluoro-acetyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ 2-(3,5-Dichlorophenyl)-2,2-difluoro-acetyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1 R ,3 S ,4 R )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2- [2-(3,5-Dichlorophenyl)-2,2-difluoro-acetyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1 R ,3 R ,4 R )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ 2-(3,5-Dichlorophenyl)-2,2-difluoro-acetyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide ;

N -(1-cyano-2-(2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-(4-methoxy-1H-indole-2-carbonyl )-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5- Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

N -(1-cyano-2-(2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-(2-methyl-1H-indole-7-carbonyl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(2-methyl-1H-indole-7-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(2-methyl-1H-indole-7-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(2-methyl-1H-indole-7-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(2-methyl-1H-indole-7-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(2-methyl-1H-indole-7-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(2-methyl-1H-indole-7-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(2-methyl-1H-indole-7-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(2-methyl-1H-indole-7-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(2-methyl-1H-indole-7-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(2-methyl-1H-indole-7-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(2-methyl-1H-indole-7-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(2-methyl-1H-indole-7-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(2-methyl-1H-indole-7-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(2-methyl-1H-indole-7-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(2-methyl-1H-indole-7-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(2-methyl-1H-indole-7-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

N -(1-cyano-2-(oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-(2-hydroxy-2-phenylacryl)-2-aza Bicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( S )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( S )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( S )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( S )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( S )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( S )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( S )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( S )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( S )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( S )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( S )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( S )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( S )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( S )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( S )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( S )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( R )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( R )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( R )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( R )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( R )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( R )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( R )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( R )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( R )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( R )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( R )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( R )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( R )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( R )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( R )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( R )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

N- (1-cyano-2-(2-oxopyrrolidin-3-yl)ethyl)-2-(4-(difluoromethyl)-1H-indole-2-carbonyl)-5, 5-Difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )- N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )- N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )- N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )- N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )- N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )- N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

N-(1-cyano-2-(2-oxopyrrolidin-3-yl)ethyl)-2-(4-(difluoromethyl)-6-fluoro-1H-indole-2-carbonyl )-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )-N-(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )-N-(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )-N-(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )-N-(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )-N-(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )-N-(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )-N-(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )-N-(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )-N-(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )-N-(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )-N-(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )-N-(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )-N-(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )-N-(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )-N-(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )-N-(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

N -[1-cyano-2-[2-oxopyrrolidin-3-yl]ethyl]-2-[3-cyclobutyl-2-[(2,2,2-trifluoroacetyl )amino] propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 S ,4 R )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 R ,4 R )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 S ,4 R )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 R ,4 R )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 S ,4 R )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 R ,4 R )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 S ,4 R )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 R ,4 R )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

2-(7-Chloro-4-fluoro-1 H -indole-2-carbonyl) -N- [1-cyano-2-[2-oxo-3-piperidinyl]ethyl]-5 ,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 S ,3 S ,4 S )-2-(7-chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 S )-1-cyano-2-[( 3S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 S ,3 R ,4 S )-2-(7-Chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 S )-1-cyano-2-[( 3S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 R ,3 S ,4 R )-2-(7-chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 S )-1-cyano-2-[( 3S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 R ,3 R ,4 R )-2-(7-chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 S )-1-cyano-2-[( 3S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 S ,3 S ,4 S )-2-(7-Chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 R )-1-cyano-2-[( 3S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 S ,3 R ,4 S )-2-(7-Chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 R )-1-cyano-2-[( 3S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 R ,3 S ,4 R )-2-(7-chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 R )-1-cyano-2-[( 3S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 R ,3 R ,4 R )-2-(7-chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 R )-1-cyano-2-[( 3S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 S ,3 S ,4 S )-2-(7-chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 S )-1-cyano-2-[( 3 R )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 S ,3 R ,4 S )-2-(7-Chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 S )-1-cyano-2-[( 3 R )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 R ,3 S ,4 R )-2-(7-chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 S )-1-cyano-2-[( 3 R )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 R ,3 R ,4 R )-2-(7-chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 S )-1-cyano-2-[( 3 R )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 S ,3 S ,4 S )-2-(7-Chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 R )-1-cyano-2-[( 3 R )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 S ,3 R ,4 S )-2-(7-Chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 R )-1-cyano-2-[( 3 R )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 R ,3 S ,4 R )-2-(7-chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 R )-1-cyano-2-[( 3 R )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 R ,3 R ,4 R )-2-(7-chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 R )-1-cyano-2-[( 3 R )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

N -(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-(9-hydroxy-9H-fennel-9-carbonyl)-2 - azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( R )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -(( R )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( R )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( R )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( S )-1-cyano-2-(( R )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -(( S )-1-cyano-2-(( R )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( S )-1-cyano-2-(( R )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( S )-1-cyano-2-(( R )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( R )-1-cyano-2-(( R )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -(( R )-1-cyano-2-(( R )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( R )-1-cyano-2-(( R )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( R )-1-cyano-2-(( R )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

N -(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-(4-methoxy-1H-indole-2-carbonyl )-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( R )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -(( R )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( R )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( R )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( S )-1-cyano-2-(( R )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -(( S )-1-cyano-2-(( R )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( S )-1-cyano-2-(( R )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( S )-1-cyano-2-(( R )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( R )-1-cyano-2-(( R )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -(( R )-1-cyano-2-(( R )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( R )-1-cyano-2-(( R )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( R )-1-cyano-2-(( R )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

N- [1-cyano-2-[2-oxo-3-piperidinyl]ethyl]-2-(4,7-difluoro-1 H -indole-2-carbonyl)-5, 5-Difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- (4,7-Difluoro- 1H -indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- (4,7-Difluoro- 1H -indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- (4,7-Difluoro- 1H -indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- (4,7-Difluoro- 1H -indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- (4,7-Difluoro- 1H -indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- (4,7-Difluoro- 1H -indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- (4,7-Difluoro- 1H -indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- (4,7-Difluoro- 1H -indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- (4,7-Difluoro- 1H -indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- (4,7-Difluoro- 1H -indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- (4,7-Difluoro- 1H -indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- (4,7-Difluoro- 1H -indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- (4,7-Difluoro- 1H -indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- (4,7-Difluoro- 1H -indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- (4,7-Difluoro- 1H -indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- (4,7-Difluoro- 1H -indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

N- [1-cyano-2-[2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-(4,6,7-trifluoro-1 H -ind Indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-(4,6,7-trifluoro-1 H -indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-(4,6,7-trifluoro-1 H -indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-(4,6,7-trifluoro-1 H -indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-(4,6,7-trifluoro-1 H -indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-(4,6,7-trifluoro-1 H -indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-(4,6,7-trifluoro-1 H -indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-(4,6,7-trifluoro-1 H -indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-(4,6,7-trifluoro-1 H -indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-(4,6,7-trifluoro-1 H -indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-(4,6,7-trifluoro-1 H -indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-(4,6,7-trifluoro-1 H -indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-(4,6,7-trifluoro-1 H -indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-(4,6,7-trifluoro-1 H -indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-(4,6,7-trifluoro-1 H -indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-(4,6,7-trifluoro-1 H -indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-(4,6,7-trifluoro-1 H -indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

2-(3-Chloro- 4H -thieno[3,2-b]pyrrole-5-carbonyl) -N- [1-cyano-2-[2-oxo-3-piperidinyl]ethyl Base]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )-2-(3-chloro-4 H -thieno[3,2-b]pyrrole-5-carbonyl) -N -[(1 S )-1-cyano- 2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )-2-(3-Chloro-4 H -thieno[3,2-b]pyrrole-5-carbonyl) -N -[(1 S )-1-cyano- 2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )-2-(3-chloro-4 H -thieno[3,2-b]pyrrole-5-carbonyl) -N -[(1 S )-1-cyano- 2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )-2-(3-chloro-4 H -thieno[3,2-b]pyrrole-5-carbonyl) -N -[(1 S )-1-cyano- 2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )-2-(3-Chloro-4 H -thieno[3,2-b]pyrrole-5-carbonyl) -N -[(1 R )-1-cyano- 2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )-2-(3-Chloro-4 H -thieno[3,2-b]pyrrole-5-carbonyl) -N -[(1 R )-1-cyano- 2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )-2-(3-chloro-4 H -thieno[3,2-b]pyrrole-5-carbonyl) -N -[(1 R )-1-cyano- 2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )-2-(3-chloro-4 H -thieno[3,2-b]pyrrole-5-carbonyl) -N -[(1 R )-1-cyano- 2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )-2-(3-chloro-4 H -thieno[3,2-b]pyrrole-5-carbonyl) -N -[(1 S )-1-cyano- 2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )-2-(3-Chloro-4 H -thieno[3,2-b]pyrrole-5-carbonyl) -N -[(1 S )-1-cyano- 2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )-2-(3-chloro-4 H -thieno[3,2-b]pyrrole-5-carbonyl) -N -[(1 S )-1-cyano- 2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )-2-(3-chloro-4 H -thieno[3,2-b]pyrrole-5-carbonyl) -N -[(1 S )-1-cyano- 2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )-2-(3-Chloro-4 H -thieno[3,2-b]pyrrole-5-carbonyl) -N -[(1 R )-1-cyano- 2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )-2-(3-Chloro-4 H -thieno[3,2-b]pyrrole-5-carbonyl) -N -[(1 R )-1-cyano- 2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )-2-(3-chloro-4 H -thieno[3,2-b]pyrrole-5-carbonyl) -N -[(1 R )-1-cyano- 2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )-2-(3-chloro-4 H -thieno[3,2-b]pyrrole-5-carbonyl) -N -[(1 R )-1-cyano- 2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N- (1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-5,5- Difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )-2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N -(( S )-1-cyano-2-((S)- 2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )-2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N -(( S )-1-cyano-2-((S)- 2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )-2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N -(( S )-1-cyano-2-((S)- 2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )-2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N -(( S )-1-cyano-2-((S)- 2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )-2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N -(( R )-1-cyano-2-((S)- 2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )-2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N -(( R )-1-cyano-2-((S)- 2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )-2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N -(( R )-1-cyano-2-((S)- 2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )-2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N -(( R )-1-cyano-2-((S)- 2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )-2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N -(( S )-1-cyano-2-((R)- 2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )-2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N -(( S )-1-cyano-2-((R)- 2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )-2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N -(( S )-1-cyano-2-((R)- 2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )-2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N -(( S )-1-cyano-2-((R)- 2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )-2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N -(( R )-1-cyano-2-((R)- 2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )-2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N -(( R )-1-cyano-2-((R)- 2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )-2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N -(( R )-1-cyano-2-((R)- 2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )-2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N -(( R )-1-cyano-2-((R)- 2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

N -[1-cyano-2-[2-oxo-3-piperidinyl]ethyl]-2-[3-cyclobutyl-2-[(2,2,2-trifluoroacetyl Base) amino] propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 R ,3 S ,4 R )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 R ,3 R ,4 R )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 R ,3 S ,4 R )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 R ,3 R ,4 R )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 R ,3 S ,4 R )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 R ,3 R ,4 R )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 R ,3 S ,4 R )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 R ,3 R ,4 R )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

N- [1-cyano-2-[2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-[4-methyl-2-[(2,2, 2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-[(2 S )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 R ,4 S ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-[(2 S )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 S ,4 R ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-[(2 S )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-[(2 S )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 S ,4 S ) -N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-[(2 S )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 R ,4 S ) -N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-[(2 S )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 S ,4 R ) -N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-[(2 S )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 R ,4 R ) -N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-[(2 S )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 S ,4 S ) -N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-[(2 S )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 R ,4 S ) -N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-[(2 S )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 S ,4 R ) -N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-[(2 S )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 R ,4 R ) -N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-[(2 S )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 S ,4 S ) -N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-[(2 S )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 R ,4 S ) -N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-[(2 S )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 S ,4 R ) -N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-[(2 S )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 R ,4 R ) -N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-[(2 S )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-Difluoro-2-[(2 R )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 R ,4 S ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-Difluoro-2-[(2 R )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 S ,4 R ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-Difluoro-2-[(2 R )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-Difluoro-2-[(2 R )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 S ,4 S ) -N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-Difluoro-2-[(2 R )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 R ,4 S ) -N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-Difluoro-2-[(2 R )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 S ,4 R ) -N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-Difluoro-2-[(2 R )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 R ,4 R ) -N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-Difluoro-2-[(2 R )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 S ,4 S ) -N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-Difluoro-2-[(2 R )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 R ,4 S ) -N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-Difluoro-2-[(2 R )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 S ,4 R ) -N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-Difluoro-2-[(2 R )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 R ,4 R ) -N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-Difluoro-2-[(2 R )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 S ,4 S ) -N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-Difluoro-2-[(2 R )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 R ,4 S ) -N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-Difluoro-2-[(2 R )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 S ,4 R ) -N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-Difluoro-2-[(2 R )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 R ,4 R ) -N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-Difluoro-2-[(2 R )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

N -[1-cyano-2-[2-oxo-3-piperidinyl]ethyl]-2-[3-cyclopropyl-2-[(2,2,2-trifluoroacetyl Base) amino] propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

N -[1-cyano-2-[2-oxo-3-piperidinyl]ethyl]-2-[3,3-dimethyl-2-[(2,2,2-trifluoro Acetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2S)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2S)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2S)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2S)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2S)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2S)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 S ,4 R )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2S)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 R ,4 R )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2S)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2S)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2S)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2S)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2S)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2S)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2S)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 S ,4 R )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2S)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 R ,4 R )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2S)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2R)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2R)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2R)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2R)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2R)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2R)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 S ,4 R )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2R)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 R ,4 R )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2R)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2R)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2R)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2R)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2R)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2R)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2R)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 S ,4 R )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2R)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 R ,4 R )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2R)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

N -[1-cyano-2-[2-oxo-3-piperidinyl]ethyl]-2-[2-(2,5-difluoroaniline)propionyl]-5,5- Difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3S)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 S )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3S)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 S )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )- N -[(1 S )-1-fluoro-2-[(3S)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 S )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3S)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 S )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3S)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 S )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3S)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 S )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )- N -[(1 R )-1-cyano-2-[(3S)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 S )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )- N -[(1 R )-1-cyano-2-[(3S)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 S )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3R)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 S )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3R)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 S )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3R)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 S )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3R)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 S )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3R)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 S )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -[(1 R )-1-cyano-2-[(3R)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 S )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -[(1 R )-1-cyano-2-[(3R)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 S )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -[(1 R )-1-cyano-2-[(3R)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 S )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3S)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 R )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3S)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 R )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3S)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 R )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3S)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 R )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3S)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 R )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3S)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 R )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )- N -[(1 R )-1-cyano-2-[(3S)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 R )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )- N -[(1 R )-1-cyano-2-[(3S)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 R )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3R)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 R )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3R)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 R )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3R)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 R )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3R)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 R )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3R)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 R )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -[(1 R )-1-cyano-2-[(3R)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 R )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -[(1 R )-1-cyano-2-[(3R)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 R )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -[(1 R )-1-cyano-2-[(3R)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 R )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

2-[2-(3-Chloro-2-methyl-aniline)propionyl]-N-[1-cyano-2-[2-oxo-3-piperidinyl]ethyl]-5 ,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1S,3S,4S)-2-[(2S)-2-(3-Chloro-2-methyl-aniline)propionyl]-N-[(1S)-1-cyano-2-[( 3S)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-[(2S)-2-(3-Chloro-2-methyl-aniline)propionyl]-N-[(1S)-1-cyano-2-[( 3S)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-[(2S)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1S)-1-cyano-2-[( 3S)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-[(2S)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1S)-1-cyano-2-[( 3S)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-[(2R)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1S)-1-cyano-2-[( 3S)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-[(2R)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1S)-1-cyano-2-[( 3S)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-[(2R)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1S)-1-cyano-2-[( 3S)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-[(2R)-2-(3-Chloro-2-methyl-aniline)propionyl]-N-[(1S)-1-cyano-2-[( 3S)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-[(2S)-2-(3-Chloro-2-methyl-aniline)propionyl]-N-[(1R)-1-cyano-2-[( 3S)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-[(2S)-2-(3-Chloro-2-methyl-aniline)propionyl]-N-[(1R)-1-cyano-2-[( 3S)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-[(2S)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1R)-1-cyano-2-[( 3S)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-[(2S)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1R)-1-cyano-2-[( 3S)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-[(2R)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1R)-1-cyano-2-[( 3S)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-[(2R)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1R)-1-cyano-2-[( 3S)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-[(2R)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1R)-1-cyano-2-[( 3S)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-[(2R)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1R)-1-cyano-2-[( 3S)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-[(2S)-2-(3-Chloro-2-methyl-aniline)propionyl]-N-[(1S)-1-cyano-2-[( 3R)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1S,3R,4S)-2-[(2S)-2-(3-Chloro-2-methyl-aniline)propionyl]-N-[(1S)-1-cyano-2-[( 3R)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1R,3S,4R)-2-[(2S)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1S)-1-cyano-2-[( 3R)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1R,3R,4R)-2-[(2S)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1S)-1-cyano-2-[( 3R)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1S,3S,4S)-2-[(2R)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1S)-1-cyano-2-[( 3R)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1S,3R,4S)-2-[(2R)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1S)-1-cyano-2-[( 3R)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1R,3S,4R)-2-[(2R)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1S)-1-cyano-2-[( 3R)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1R,3R,4R)-2-[(2R)-2-(3-Chloro-2-methyl-aniline)propionyl]-N-[(1S)-1-cyano-2-[( 3R)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1S,3S,4S)-2-[(2S)-2-(3-Chloro-2-methyl-aniline)propionyl]-N-[(1R)-1-cyano-2-[( 3R)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1S,3R,4S)-2-[(2S)-2-(3-Chloro-2-methyl-aniline)propionyl]-N-[(1R)-1-cyano-2-[( 3R)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1R,3S,4R)-2-[(2S)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1R)-1-cyano-2-[( 3R)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1R,3R,4R)-2-[(2S)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1R)-1-cyano-2-[( 3R)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1S,3S,4S)-2-[(2R)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1R)-1-cyano-2-[( 3R)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1S,3R,4S)-2-[(2R)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1R)-1-cyano-2-[( 3R)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1R,3S,4R)-2-[(2R)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1R)-1-cyano-2-[( 3R)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1R,3R,4R)-2-[(2R)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1R)-1-cyano-2-[( 3R)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

N-(4-hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)-2-(2-methyl-4H-thieno[3, 2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-formamide;

(S)-N-((S)-4-hydroxyl-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 2-methyl-4H-thieno[3,2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((S)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 2-methyl-4H-thieno[3,2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((R)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 2-methyl-4H-thieno[3,2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((R)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 2-methyl-4H-thieno[3,2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((S)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 2-methyl-4H-thieno[3,2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((S)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 2-methyl-4H-thieno[3,2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((R)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 2-methyl-4H-thieno[3,2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((R)-4-hydroxyl-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 2-methyl-4H-thieno[3,2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

2-(3-Chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-(4-hydroxy-3-oxo-1-(2-oxopyrrolidine-3- Base) butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-4-hydroxyl-3-oxo-1-(( S) -2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-4-hydroxyl-3-oxo-1-(( R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-2-(3-Chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-4-hydroxyl-3-oxo-1-(( S) -2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-2-(3-Chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-4-hydroxyl-3-oxo-1-(( R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-4-hydroxyl-3-oxo-1-(( S) -2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-4-hydroxyl-3-oxo-1-(( R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-4-hydroxyl-3-oxo-1-(( S) -2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-4-hydroxyl-3-oxo-1-(( R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

N-(4-Hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)-2-(4-methoxy-1H-indole-2 -carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((S)-4-hydroxyl-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((S)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((R)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((R)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((S)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((S)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((R)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((R)-4-hydroxyl-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

N-(4-hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)-2-(3-methyl-4H-thieno[3, 2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-formamide;

(S)-N-((S)-4-hydroxyl-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 3-methyl-4H-thieno[3,2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((S)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 3-methyl-4H-thieno[3,2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((R)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 3-methyl-4H-thieno[3,2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((R)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 3-methyl-4H-thieno[3,2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((S)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 3-methyl-4H-thieno[3,2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((S)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 3-methyl-4H-thieno[3,2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((R)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 3-methyl-4H-thieno[3,2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((R)-4-hydroxyl-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 3-methyl-4H-thieno[3,2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

2-(4,6-Difluoro-1H-indole-2-carbonyl)-N-(4-hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane- 2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-2-(4,6-difluoro-1H-indole-2-carbonyl)-N-((S)-4-hydroxy-3-oxo-1-((S)-2- Oxypyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-2-(4,6-difluoro-1H-indole-2-carbonyl)-N-((S)-4-hydroxy-3-oxo-1-((R)-2- Oxypyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-2-(4,6-difluoro-1H-indole-2-carbonyl)-N-((R)-4-hydroxy-3-oxo-1-((S)-2- Oxypyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-2-(4,6-difluoro-1H-indole-2-carbonyl)-N-((R)-4-hydroxy-3-oxo-1-((R)-2- Oxypyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-2-(4,6-difluoro-1H-indole-2-carbonyl)-N-((S)-4-hydroxy-3-oxo-1-((S)-2- Oxypyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-2-(4,6-difluoro-1H-indole-2-carbonyl)-N-((S)-4-hydroxy-3-oxo-1-((R)-2- Oxypyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-2-(4,6-difluoro-1H-indole-2-carbonyl)-N-((R)-4-hydroxy-3-oxo-1-((S)-2- Oxypyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-2-(4,6-difluoro-1H-indole-2-carbonyl)-N-((R)-4-hydroxy-3-oxo-1-((R)-2- Oxypyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

2-(9-fluoro-9H-fluorene-9-carbonyl)-N-(4-hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-(9-fluoro-9H-fennel-9-carbonyl)-N-((S)-4-hydroxyl-3-oxo-1-((S)-2- Oxypyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-(9-Fluoro-9H-fennel-9-carbonyl)-N-((S)-4-hydroxy-3-oxo-1-((R)-2- Oxypyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-(9-Fluoro-9H-fennel-9-carbonyl)-N-((R)-4-hydroxyl-3-oxo-1-((S)-2- Oxypyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-(9-Fluoro-9H-fennel-9-carbonyl)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2- Oxypyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-(9-Fluoro-9H-fennel-9-carbonyl)-N-((S)-4-hydroxy-3-oxo-1-((S)-2- Oxypyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-(9-Fluoro-9H-fennel-9-carbonyl)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2- Oxypyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-(9-Fluoro-9H-fennel-9-carbonyl)-N-((R)-4-hydroxyl-3-oxo-1-((S)-2- Oxypyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-(9-Fluoro-9H-fennel-9-carbonyl)-N-((R)-4-hydroxyl-3-oxo-1-((R)-2- Oxypyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-(9-fluoro-9H-fennel-9-carbonyl)-N-((S)-4-hydroxyl-3-oxo-1-((S)-2- Oxypyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-(9-Fluoro-9H-fennel-9-carbonyl)-N-((S)-4-hydroxy-3-oxo-1-((R)-2- Oxypyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-(9-Fluoro-9H-fennel-9-carbonyl)-N-((R)-4-hydroxyl-3-oxo-1-((S)-2- Oxypyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-(9-Fluoro-9H-fennel-9-carbonyl)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2- Oxypyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-(9-Fluoro-9H-fennel-9-carbonyl)-N-((S)-4-hydroxy-3-oxo-1-((S)-2- Oxypyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-(9-Fluoro-9H-fennel-9-carbonyl)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2- Oxypyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-(9-Fluoro-9H-fennel-9-carbonyl)-N-((R)-4-hydroxyl-3-oxo-1-((S)-2- Oxypyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-(9-Fluoro-9H-fennel-9-carbonyl)-N-((R)-4-hydroxyl-3-oxo-1-((R)-2- Oxypyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

2-(9-Acetamido-9H-oxo-9-carbonyl)-N-(4-hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2 -yl) octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-(9-Acetamido-9H-oxo-9-carbonyl)-N-((S)-4-hydroxy-3-oxo-1-((S) -2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-(9-Acetamido-9H-oxo-9-carbonyl)-N-((S)-4-hydroxy-3-oxo-1-((R) -2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-(9-Acetamido-9H-oxo-9-carbonyl)-N-((R)-4-hydroxy-3-oxo-1-((S) -2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-(9-Acetamido-9H-oxo-9-carbonyl)-N-((R)-4-hydroxy-3-oxo-1-((R) -2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-(9-Acetamido-9H-oxo-9-carbonyl)-N-((S)-4-hydroxyl-3-oxo-1-((S) -2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-(9-Acetamido-9H-oxo-9-carbonyl)-N-((S)-4-hydroxy-3-oxo-1-((R) -2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-(9-Acetamido-9H-oxo-9-carbonyl)-N-((R)-4-hydroxy-3-oxo-1-((S) -2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-(9-Acetamido-9H-oxo-9-carbonyl)-N-((R)-4-hydroxy-3-oxo-1-((R) -2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-(9-Acetamido-9H-oxo-9-carbonyl)-N-((S)-4-hydroxy-3-oxo-1-((S) -2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-(9-Acetamido-9H-oxo-9-carbonyl)-N-((S)-4-hydroxy-3-oxo-1-((R) -2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-(9-Acetamido-9H-oxo-9-carbonyl)-N-((R)-4-hydroxy-3-oxo-1-((S) -2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-(9-Acetamido-9H-oxo-9-carbonyl)-N-((R)-4-hydroxy-3-oxo-1-((R) -2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-(9-Acetamido-9H-oxo-9-carbonyl)-N-((S)-4-hydroxyl-3-oxo-1-((S) -2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-(9-Acetamido-9H-oxo-9-carbonyl)-N-((S)-4-hydroxy-3-oxo-1-((R) -2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-(9-Acetamido-9H-oxo-9-carbonyl)-N-((R)-4-hydroxy-3-oxo-1-((S) -2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-(9-Acetamido-9H-oxo-9-carbonyl)-N-((R)-4-hydroxy-3-oxo-1-((R) -2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

N-(4-Hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)-2-(5-oxo-2-phenylpyrrolidine -2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-((S)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((R)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((S)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((R)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((S)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-((R)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((S)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((R)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((S)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((R)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((S)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-((R)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-((S)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((R)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-((S)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((R)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((S)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((R)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-((S)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-((R)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-((S)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-((R)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-((S)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-((R)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((S)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((R)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-((S)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-((R)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((S)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((R)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((S)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((R)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

2-(2-Cyclopentyl-2-hydroxy-2-phenylacetyl)-N-(4-hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane -2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(3S)-2-(2-Cyclopentyl-2-hydroxy-2-phenylacetyl)-N-((S)-4-hydroxy-3-oxo-1-((S)-2 -Oxopyrrolidin-3-yl)butan-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-2-((S)-2-cyclopentyl-2-hydroxyl-2-phenylacetyl)-N-((S)-4-hydroxyl-3-oxo-1-(( S) -2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-2-((S)-2-cyclopentyl-2-hydroxyl-2-phenylacetyl)-N-((S)-4-hydroxyl-3-oxo-1-(( R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-2-((S)-2-cyclopentyl-2-hydroxyl-2-phenylacetyl)-N-((R)-4-hydroxyl-3-oxo-1-(( S) -2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-2-((S)-2-cyclopentyl-2-hydroxyl-2-phenylacetyl)-N-((R)-4-hydroxyl-3-oxo-1-(( R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-2-((R)-2-cyclopentyl-2-hydroxyl-2-phenylacetyl)-N-((S)-4-hydroxyl-3-oxo-1-(( S) -2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-2-((R)-2-cyclopentyl-2-hydroxyl-2-phenylacetyl)-N-((S)-4-hydroxyl-3-oxo-1-(( R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-2-((R)-2-cyclopentyl-2-hydroxyl-2-phenylacetyl)-N-((R)-4-hydroxyl-3-oxo-1-(( S) -2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-2-((R)-2-cyclopentyl-2-hydroxyl-2-phenylacetyl)-N-((R)-4-hydroxyl-3-oxo-1-(( R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-2-((S)-2-cyclopentyl-2-hydroxyl-2-phenylacetyl)-N-((S)-4-hydroxyl-3-oxo-1-(( S) -2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-2-((S)-2-cyclopentyl-2-hydroxyl-2-phenylacetyl)-N-((S)-4-hydroxyl-3-oxo-1-(( R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-2-((S)-2-cyclopentyl-2-hydroxyl-2-phenylacetyl)-N-((R)-4-hydroxyl-3-oxo-1-(( S) -2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-2-((S)-2-cyclopentyl-2-hydroxyl-2-phenylacetyl)-N-((R)-4-hydroxyl-3-oxo-1-(( R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-2-((R)-2-cyclopentyl-2-hydroxy-2-phenylacetyl)-N-((S)-4-hydroxy-3-oxo-1-(( S) -2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-2-((R)-2-cyclopentyl-2-hydroxy-2-phenylacetyl)-N-((S)-4-hydroxy-3-oxo-1-(( R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-2-((R)-2-cyclopentyl-2-hydroxyl-2-phenylacetyl)-N-((R)-4-hydroxyl-3-oxo-1-(( S) -2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-2-((R)-2-cyclopentyl-2-hydroxyl-2-phenylacetyl)-N-((R)-4-hydroxyl-3-oxo-1-(( R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

N-(1-cyano-2-(2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo [2.2.2] Octane-3-formamide;

(S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy-1H-ind Indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy-1H-ind Indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2,-(4-methoxy-1H- Indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy-1H-ind Indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy-1H-ind Indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy-1H-ind Indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy-1H-ind Indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy-1H-ind Indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

2-(3-Chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-(1-cyano-2-(2-oxopyrrolidin-3-yl)ethyl) -5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-(3-Chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-1-cyano-2-((S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-(3-Chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-1-cyano-2-((R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-1-cyano-2-((S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-(3-Chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-1-cyano-2-((R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-1-cyano-2-((S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-(3-Chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-1-cyano-2-((R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-1-cyano-2-((S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-1-cyano-2-((R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-(3-Chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-1-cyano-2-((S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-(3-Chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-1-cyano-2-((R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-1-cyano-2-((S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-1-cyano-2-((R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-1-cyano-2-((S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-1-cyano-2-((R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-1-cyano-2-((S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-1-cyano-2-((R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,2S,5S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-3-(9-hydroxyl-9H -Treme-9-carbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide;

N-(1-cyano-2-(2-oxopyrrolidin-3-yl)ethyl)-3-(9-hydroxy-9H-fenflure-9-carbonyl)-6,6-dimethyl- 3-Azabicyclo[3.1.0]hexane-2-carboxamide;

(1R,2S,5S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-3-(9-hydroxyl-9H -Treme-9-carbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide;

(1R,2S,5S)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-3-(9-hydroxyl-9H -Treme-9-carbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide;

(1R,2S,5S)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-3-(9-hydroxyl-9H -Treme-9-carbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide;

(1R,2S,5S)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-3-(9-hydroxyl-9H -Treme-9-carbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide;

(1S,2S,5R)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-3-(9-hydroxyl-9H -Treme-9-carbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide;

(1S,2S,5R)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-3-(9-hydroxyl-9H -Treme-9-carbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide;

(1S,2S,5R)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-3-(9-hydroxyl-9H -Treme-9-carbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide;

(1S,2S,5R)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-3-(9-hydroxyl-9H -Treme-9-carbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide;

(1R,2R,5S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-3-(9-hydroxyl-9H -Treme-9-carbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide;

(1R,2R,5S)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-3-(9-hydroxyl-9H -Treme-9-carbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide;

(1R,2R,5S)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-3-(9-hydroxyl-9H -Treme-9-carbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide;

(1R,2R,5S)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-3-(9-hydroxyl-9H -Treme-9-carbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide;

(1S,2R,5R)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-3-(9-hydroxyl-9H -Treme-9-carbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide;

(1S,2R,5R)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-3-(9-hydroxyl-9H -Treme-9-carbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide;

(1S,2R,5R)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-3-(9-hydroxyl-9H -Treme-9-carbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide;

(1S,2R,5R)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-3-(9-hydroxyl-9H -Treme-9-carbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide;

N-(1-cyano-2-(2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-((2,2,2-trifluoroacetyl)- Leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-D-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-L-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-D-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-L-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-D-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-L-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-D-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-L-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-D-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-L-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-D-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-L-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-D-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-L-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-D-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-L-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-D-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-L-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-D-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-L-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-D-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-L-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-D-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-L-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-D-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-L-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-D-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-L-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-D-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-L-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-D-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-L-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

N-(1-cyano-2-(2-oxopyrrolidin-3-yl)ethyl)-2-(3-cyclobutyl-2-(2,2,2-trifluoroacetamido ) propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3S,4S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3S,4S)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3S,4S)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3S,4S)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3S,4S)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3S,4S)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3S,4S)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3S,4R)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3S,4R)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3S,4R)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3S,4R)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3S,4R)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3S,4R)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3S,4R)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3S,4R)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3R,4S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3R,4S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3R,4S)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3R,4S)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3R,4S)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3R,4S)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3R,4S)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3R,4S)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3R,4R)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3R,4R)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3R,4R)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3R,4R)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3R,4R)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3R,4R)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3R,4R)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3R,4R)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N- (1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-5,5- Difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )-2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N -(( S )-1-cyano-2-((S)- 2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((S)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((S)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((S)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((S)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((R)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((R)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((R)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((R)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((S)-2-chloro-9-hydroxyl-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((S)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((S)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((S)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((R)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((R)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((R)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((R)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((S)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((S)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((S)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((S)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((R)-2-Chloro-9-hydroxyl-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((R)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((R)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((R)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((S)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((S)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((S)-2-chloro-9-hydroxyl-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((S)-2-chloro-9-hydroxyl-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((R)-2-chloro-9-hydroxyl-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((R)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((R)-2-chloro-9-hydroxyl-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((R)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo [2.2.2] Octane-3-formamide;

(S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-methoxy-1H-ind Indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-methoxy-1H-ind Indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-methoxy-1H-ind Indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-methoxy-1H-ind Indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-methoxy-1H-ind Indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-methoxy-1H-ind Indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-methoxy-1H-ind Indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-methoxy-1H-ind Indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-D-leucyl)-N-((S)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-D-leucyl)-N-((S)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-D-leucyl)-N-((S)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-D-leucyl)-N-((R)-1-fluoro-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-D-leucyl)-N-((R)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-L-leucyl)-N-((S)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-L-leucyl)-N-((S)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-L-leucyl)-N-((R)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-L-leucyl)-N-((R)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-D-leucyl)-N-((S)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-D-leucyl)-N-((S)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-D-leucyl)-N-((R)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-D-leucyl)-N-((R)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-L-leucyl)-N-((S)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-L-leucyl)-N-((S)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-L-leucyl)-N-((R)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-L-leucyl)-N-((R)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((3-Chlorophenyl)-D-leucyl)-N-((S)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((3-Chlorophenyl)-D-leucyl)-N-((S)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((3-Chlorophenyl)-D-leucyl)-N-((R)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((3-Chlorophenyl)-D-leucyl)-N-((R)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((3-Chlorophenyl)-L-leucyl)-N-((S)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((3-Chlorophenyl)-L-leucyl)-N-((S)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((3-Chlorophenyl)-L-leucyl)-N-((R)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((3-Chlorophenyl)-L-leucyl)-N-((R)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((3-Chlorophenyl)-D-leucyl)-N-((S)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((3-Chlorophenyl)-D-leucyl)-N-((S)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((3-Chlorophenyl)-D-leucyl)-N-((R)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((3-Chlorophenyl)-D-leucyl)-N-((R)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((3-Chlorophenyl)-L-leucyl)-N-((S)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((3-Chlorophenyl)-L-leucyl)-N-((S)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((3-Chlorophenyl)-L-leucyl)-N-((R)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((3-Chlorophenyl)-L-leucyl)-N-((R)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

2-(2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl Base)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((S)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((S)-1-cyano -2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((S)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((S)-1-cyano -2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((S)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((R)-1-cyano -2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((S)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((R)-1-cyano -2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((R)-2-((3-Chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((S)-1-cyano -2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((R)-2-((3-Chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((S)-1-cyano -2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((R)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((R)-1-cyano -2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((R)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((R)-1-cyano -2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((S)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((S)-1-cyano -2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((S)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((S)-1-cyano -2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((S)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((R)-1-cyano -2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((S)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((R)-1-cyano -2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((R)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((S)-1-cyano -2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((R)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((S)-1-cyano -2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((R)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((R)-1-cyano -2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((R)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((R)-1-cyano -2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((S)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((S)-1-cyano -2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((S)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((S)-1-cyano -2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((S)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((R)-1-cyano -2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((S)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((R)-1-cyano -2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((R)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((S)-1-cyano -2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((R)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((S)-1-cyano -2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((R)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((R)-1-cyano -2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((R)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((R)-1-cyano -2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((S)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((S)-1-cyano -2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((S)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((S)-1-cyano -2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((S)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((R)-1-cyano -2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((S)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((R)-1-cyano -2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((R)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((S)-1-cyano -2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((R)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((S)-1-cyano -2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((R)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((R)-1-cyano -2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((R)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((R)-1-cyano -2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-2-(3-cyclopropyl-2-((5-methylpyridin-3-yl)amine Base) propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3S,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3S,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3S,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3S,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3S,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3S,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3S,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3S,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3S,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3S,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3S,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3S,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3S,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3S,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3S,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3R,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3R,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3R,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3R,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3R,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3R,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3R,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3R,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3R,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3R,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3R,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3R,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3R,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3R,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3R,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3R,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl)-propanylamino)-5,5-difluoro -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-D-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-L-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-D-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-L-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-D-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-L-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-D-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-L-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-D-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-L-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-D-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-L-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-D-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-L-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-D-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-L-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-D-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-L-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-D-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-L-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-D-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-L-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-D-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-L-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-D-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-L-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-D-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-L-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-D-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-L-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-D-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-L-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

2-((5-chloropyridin-3-yl)-propanylamino)-N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-5,5-difluoro -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((5-Chloropyridin-3-yl)-D-propanylamino)-N-((S)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((5-Chloropyridin-3-yl)-D-propanylamino)-N-((S)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((5-Chloropyridin-3-yl)-D-propanylamino)-N-((R)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((5-Chloropyridin-3-yl)-D-propanylamino)-N-((R)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((5-Chloropyridin-3-yl)-L-propanylamino)-N-((S)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((5-Chloropyridin-3-yl)-L-propanylamino)-N-((S)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((5-Chloropyridin-3-yl)-L-propanylamino)-N-((R)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((5-Chloropyridin-3-yl)-L-propanylamino)-N-((R)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((5-Chloropyridin-3-yl)-D-propanylamino)-N-((S)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((5-Chloropyridin-3-yl)-D-propanylamino)-N-((S)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((5-Chloropyridin-3-yl)-D-propanamide)-N-((R)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((5-Chloropyridin-3-yl)-D-propanamide)-N-((R)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((5-Chloropyridin-3-yl)-L-propanylamino)-N-((S)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((5-Chloropyridin-3-yl)-L-propanylamino)-N-((S)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((5-Chloropyridin-3-yl)-L-propanylamino)-N-((R)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((5-Chloropyridin-3-yl)-L-propanylamino)-N-((R)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((5-Chloropyridin-3-yl)-D-propanylamino)-N-((S)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((5-Chloropyridin-3-yl)-D-propanylamino)-N-((S)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((5-Chloropyridin-3-yl)-D-propanylamino)-N-((R)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((5-Chloropyridin-3-yl)-D-propanamide)-N-((R)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((5-Chloropyridin-3-yl)-L-propanylamino)-N-((S)-1-cyano-2-((S)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((5-Chloropyridin-3-yl)-L-propanylamino)-N-((S)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((5-Chloropyridin-3-yl)-L-propanylamino)-N-((R)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((5-Chloropyridin-3-yl)-L-propanylamino)-N-((R)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((5-Chloropyridin-3-yl)-D-propanylamino)-N-((S)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((5-Chloropyridin-3-yl)-D-propanylamino)-N-((S)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((5-Chloropyridin-3-yl)-D-propanamide)-N-((R)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((5-Chloropyridin-3-yl)-D-propanylamino)-N-((R)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((5-Chloropyridin-3-yl)-L-propanamide)-N-((S)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((5-Chloropyridin-3-yl)-L-propanylamino)-N-((S)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((5-chloropyridin-3-yl)-L-propanylamino)-N-((R)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((5-Chloropyridin-3-yl)-L-propanylamino)-N-((R)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

2-((3-Chlorophenyl)-propanylamino)-N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2- Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-D-propanylamino)-N-((S)-1-cyano-2-((S)-2-oxopiperidine -3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-D-propanylamino)-N-((S)-1-cyano-2-((R)-2-oxopiperidine -3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-D-propanylamino)-N-((R)-1-cyano-2-((S)-2-oxopiperidine -3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-D-propanylamino)-N-((R)-1-cyano-2-((R)-2-oxopiperidine -3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-L-propanylamino)-N-((S)-1-cyano-2-((S)-2-oxopiperidine -3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-L-propanylamino)-N-((S)-1-cyano-2-((R)-2-oxopiperidine -3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-L-propanylamino)-N-((R)-1-cyano-2-((S)-2-oxopiperidine -3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-L-propanylamino)-N-((R)-1-cyano-2-((R)-2-oxopiperidine -3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-D-propanylamino)-N-((S)-1-cyano-2-((S)-2-oxopiperidine -3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-D-propanylamino)-N-((S)-1-cyano-2-((R)-2-oxopiperidine -3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-D-propanylamino)-N-((R)-1-cyano-2-((S)-2-oxopiperidine -3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-D-propanylamino)-N-((R)-1-cyano-2-((R)-2-oxopiperidine -3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-L-propanylamino)-N-((S)-1-cyano-2-((S)-2-oxopiperidine -3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-L-propanylamino)-N-((S)-1-cyano-2-((R)-2-oxopiperidine -3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-L-propanylamino)-N-((R)-1-cyano-2-((S)-2-oxopiperidine -3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-L-propanylamino)-N-((R)-1-cyano-2-((R)-2-oxopiperidine -3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-D-propanylamino)-N-((S)-1-cyano-2-((S)-2-oxopiperidine -3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-D-propanylamino)-N-((S)-1-cyano-2-((R)-2-oxopiperidine -3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-D-propanylamino)-N-((R)-1-cyano-2-((S)-2-oxopiperidine -3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-D-propanylamino)-N-((R)-1-cyano-2-((R)-2-oxopiperidine -3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-L-propanylamino)-N-((S)-1-cyano-2-((S)-2-oxopiperidine -3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-L-propanylamino)-N-((S)-1-cyano-2-((R)-2-oxopiperidine -3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-L-propanylamino)-N-((R)-1-cyano-2-((S)-2-oxopiperidine -3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-L-propanylamino)-N-((R)-1-cyano-2-((R)-2-oxopiperidine -3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-D-propanylamino)-N-((S)-1-cyano-2-((S)-2-oxopiperidine -3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-D-propanylamino)-N-((S)-1-cyano-2-((R)-2-oxopiperidine -3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-D-propanylamino)-N-((R)-1-cyano-2-((S)-2-oxopiperidine -3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-D-propanylamino)-N-((R)-1-cyano-2-((R)-2-oxopiperidine -3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-L-propanylamino)-N-((S)-1-cyano-2-((S)-2-oxopiperidine -3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-L-propanylamino)-N-((S)-1-cyano-2-((R)-2-oxopiperidine -3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-L-propanylamino)-N-((R)-1-cyano-2-((S)-2-oxopiperidine -3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-L-propanylamino)-N-((R)-1-cyano-2-((R)-2-oxopiperidine -3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-2-(3-cyclopropyl-2-((1-methyl-1H-pyrazole-4 -yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1S,3S,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1S,3S,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1S,3S,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1S,3S,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1S,3S,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1S,3S,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperene-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1S,3S,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1R,3S,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1R,3S,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1R,3S,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1R,3S,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1R,3S,4R)-N-((R)-1-cyano-2-((S)-2-oxopernic-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1R,3S,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1R,3S,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1R,3S,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1S,3R,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1S,3R,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1S,3R,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1S,3R,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1S,3R,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1S,3R,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperene-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1S,3R,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1S,3R,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1R,3R,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1R,3R,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1R,3R,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1R,3R,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1R,3R,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1R,3R,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1R,3R,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1R,3R,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

2-((3-Chloro-2-methylphenyl)glycyl)-N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-5,5- Difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-N-((S)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-N-((S)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-N-((R)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-N-((R)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-chloro-2-methylphenyl)glycyl)-N-((S)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-N-((S)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-N-((R)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-N-((R)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-N-((S)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-N-((S)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-N-((R)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-N-((R)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-N-((S)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-N-((S)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-N-((R)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-N-((R)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

2-(1-((3-chlorophenyl)amino)cyclopropane-1-carbonyl)-N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)- 5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-(1-((3-Chlorophenyl)amino)cyclopropane-1-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-(1-((3-Chlorophenyl)amino)cyclopropane-1-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-(1-((3-Chlorophenyl)amino)cyclopropane-1-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-(1-((3-Chlorophenyl)amino)cyclopropane-1-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-(1-((3-Chlorophenyl)amino)cyclopropane-1-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-(1-((3-Chlorophenyl)amino)cyclopropane-1-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-(1-((3-Chlorophenyl)amino)cyclopropane-1-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-(1-((3-Chlorophenyl)amino)cyclopropane-1-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-(1-((3-Chlorophenyl)amino)cyclopropane-1-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-(1-((3-Chlorophenyl)amino)cyclopropane-1-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-(1-((3-Chlorophenyl)amino)cyclopropane-1-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-(1-((3-Chlorophenyl)amino)cyclopropane-1-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-(1-((3-Chlorophenyl)amino)cyclopropane-1-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-(1-((3-Chlorophenyl)amino)cyclopropane-1-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-(1-((3-Chlorophenyl)amino)cyclopropane-1-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-(1-((3-Chlorophenyl)amino)cyclopropane-1-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl)-propanamide)-2-azabicyclo[ 2.2.2] Octane-3-formamide;

(S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-D-propanylamino)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-L-propanylamino)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-D-propanylamino)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-L-propanylamino)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-D-propanylamino)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-L-propanylamino)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-D-propanylamino)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-L-propanylamino)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-D-propanylamino)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-L-propanylamino)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-D-propanylamino)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-L-propanylamino)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-D-propanylamino)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-L-propanylamino)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-D-propanylamino)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-L-propanylamino)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-L-propanylamino)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-L-propanylamino)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-D-propanylamino)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-L-propanylamino)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-D-propanylamino)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-L-propanylamino)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-D-propanylamino)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-L-propanylamino)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-D-propanylamino)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-L-propanylamino)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-D-propanylamino)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-L-propanylamino)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-D-propanylamino)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-L-propanylamino)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-D-propanylamino)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-L-propanylamino)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-D-propanylamino)-2-azabicyclo[2.2.2]octane-3-carboxamide;

N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-(2-hydroxy-2-phenylacetyl)-2- Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((S)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((R)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((S)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((R)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((S)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((R)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((S)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((R)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((S)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((R)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((S)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((R)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((S)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((R)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((S)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((R)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((S)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((R)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((S)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((R)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((S)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((R)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((S)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((R)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((S)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((R)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((S)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((R)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((S)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((R)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((S)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((R)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

2-((3-chlorophenyl)-leucyl)-N-(1-cyano-2-(2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro- 2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-D-leucyl)-N-((S)-1-cyano-2-((S)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-D-leucyl)-N-((S)-1-cyano-2-((R)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-D-leucyl)-N-((R)-1-cyano-2-((S)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-D-leucyl)-N-((R)-1-cyano-2-((R)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-L-leucyl)-N-((S)-1-cyano-2-((S)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-L-leucyl)-N-((S)-1-cyano-2-((R)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-L-leucyl)-N-((R)-1-cyano-2-((S)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-L-leucyl)-N-((R)-1-cyano-2-((R)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-D-leucyl)-N-((S)-1-cyano-2-((S)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-D-leucyl)-N-((S)-1-cyano-2-((R)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-D-leucyl)-N-((R)-1-cyano-2-((S)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-D-leucyl)-N-((R)-1-cyano-2-((R)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-L-leucyl)-N-((S)-1-cyano-2-((S)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-L-leucyl)-N-((S)-1-cyano-2-((R)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-L-leucyl)-N-((R)-1-cyano-2-((S)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-L-leucyl)-N-((R)-1-cyano-2-((R)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((3-Chlorophenyl)-D-leucyl)-N-((S)-1-cyano-2-((S)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((3-Chlorophenyl)-D-leucyl)-N-((S)-1-cyano-2-((R)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((3-Chlorophenyl)-D-leucyl)-N-((R)-1-cyano-2-((S)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((3-Chlorophenyl)-D-leucyl)-N-((R)-1-cyano-2-((R)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((3-Chlorophenyl)-L-leucyl)-N-((S)-1-cyano-2-((S)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((3-Chlorophenyl)-L-leucyl)-N-((S)-1-cyano-2-((R)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((3-Chlorophenyl)-L-leucyl)-N-((R)-1-cyano-2-((S)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((3-Chlorophenyl)-L-leucyl)-N-((R)-1-cyano-2-((R)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((3-Chlorophenyl)-D-leucyl)-N-((S)-1-cyano-2-((S)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((3-Chlorophenyl)-D-leucyl)-N-((S)-1-cyano-2-((R)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((3-Chlorophenyl)-D-leucyl)-N-((R)-1-cyano-2-((S)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((3-Chlorophenyl)-D-leucyl)-N-((R)-1-cyano-2-((R)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((3-Chlorophenyl)-L-leucyl)-N-((S)-1-cyano-2-((S)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((3-Chlorophenyl)-L-leucyl)-N-((S)-1-cyano-2-((R)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((3-Chlorophenyl)-L-leucyl)-N-((R)-1-cyano-2-((S)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((3-Chlorophenyl)-L-leucyl)-N-((R)-1-cyano-2-((R)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

N-(1-cyano-2-(2-oxopyrrolidin-3-yl)ethyl)-2-(3-cyclopropyl-2-((5-methylpyridin-3-yl)amine Base) propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3S,4S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3S,4S)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3S,4S)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3S,4S)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3S,4S)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3S,4S)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3S,4S)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3S,4R)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3S,4R)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3S,4R)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3S,4R)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3S,4R)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3S,4R)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3S,4R)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3S,4R)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3R,4S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3R,4S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3R,4S)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3R,4S)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3R,4S)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3R,4S)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3R,4S)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3R,4S)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3R,4R)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3R,4R)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3R,4R)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3R,4R)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3R,4R)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3R,4R)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3R,4R)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3R,4R)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

5,5-Difluoro-N-(4-fluoro-4-(methylsulfonyl)-1-(2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2 -(9-Hydroxy-9H-fen-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-5,5-Difluoro-N-((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3S,4S)-5,5-Difluoro-N-((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3S,4S)-5,5-Difluoro-N-((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3S,4S)-5,5-Difluoro-N-((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3S,4S)-5,5-Difluoro-N-((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3S,4S)-5,5-Difluoro-N-((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3S,4S)-5,5-Difluoro-N-((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3S,4S)-5,5-Difluoro-N-((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3S,4R)-5,5-Difluoro-N-((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3S,4R)-5,5-Difluoro-N-((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3S,4R)-5,5-Difluoro-N-((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3S,4R)-5,5-Difluoro-N-((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3S,4R)-5,5-Difluoro-N-((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3S,4R)-5,5-Difluoro-N-((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3S,4R)-5,5-Difluoro-N-((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3S,4R)-5,5-Difluoro-N-((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3R,4S)-5,5-Difluoro-N-((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3R,4S)-5,5-Difluoro-N-((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3R,4S)-5,5-Difluoro-N-((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3R,4S)-5,5-Difluoro-N-((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3R,4S)-5,5-Difluoro-N-((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3R,4S)-5,5-Difluoro-N-((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3R,4S)-5,5-Difluoro-N-((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3R,4S)-5,5-Difluoro-N-((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3R,4R)-5,5-Difluoro-N-((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3R,4R)-5,5-Difluoro-N-((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3R,4R)-5,5-Difluoro-N-((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3R,4R)-5,5-Difluoro-N-((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3R,4R)-5,5-Difluoro-N-((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3R,4R)-5,5-Difluoro-N-((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3R,4R)-5,5-Difluoro-N-((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3R,4R)-5,5-Difluoro-N-((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

N-(4-fluoro-4-(methylsulfonyl)-1-(2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-(9-hydroxyl-9H -Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

2-(2-Acetamido-2-phenylacetyl)-N-(4-fluoro-4-(methylsulfonyl)-1-(2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((R,E)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((R,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((R,E)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((R,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((R,E)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((R,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((R,E)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((R,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((R,E)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((R,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((R,E)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((R,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((R,E)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((R,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((R,E)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((R,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

2-(3,3-Dimethyl-2-(2,2,2-trifluoroacetylamino)butyryl)-N-(4-fluoro-4-(methylsulfonyl)-1-( 2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

2-(3,3-Dimethyl-2-(2,2,2-trifluoroacetylamino)butyryl)-N-(4-fluoro-4-(methylsulfonyl)-1-( 2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

2-(3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N-(4-fluoro-4-(methylsulfonyl Acyl)-1-(2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N- ((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)eta Hydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-(4-fluoro-4-(methylsulfonyl)-1-(2-oxopyrrolidine -3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3S,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3S,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3S,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3S,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3S,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3S,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3S,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3S,4R)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3S,4R)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3S,4R)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3S,4R)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3S,4R)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3S,4R)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3S,4R)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3S,4R)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3R,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3R,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3R,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3R,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3R,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3R,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3R,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3R,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3R,4R)-2-(7-chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3R,4R)-2-(7-chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3R,4R)-2-(7-chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3R,4R)-2-(7-chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3R,4R)-2-(7-chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3R,4R)-2-(7-chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3R,4R)-2-(7-chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3R,4R)-2-(7-chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-(4-fluoro-4-(methylsulfonyl)-1-(2-oxopyrrolidine -3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3S,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3S,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3S,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3S,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3S,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3S,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3S,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3S,4R)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3S,4R)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3S,4R)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3S,4R)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3S,4R)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3S,4R)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3S,4R)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3S,4R)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3R,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3R,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3R,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3R,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3R,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3R,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3R,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3R,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3R,4R)-2-(7-chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3R,4R)-2-(7-chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3R,4R)-2-(7-chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3R,4R)-2-(7-chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3R,4R)-2-(7-chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3R,4R)-2-(7-chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3R,4R)-2-(7-chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3R,4R)-2-(7-chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-(4-fluoro-4-(methylsulfonyl)-1-(2-oxo Pyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1S,3S,4S)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1S,3S,4S)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1S,3S,4S)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1S,3S,4S)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1S,3S,4S)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1S,3S,4S)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1S,3S,4S)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1R,3S,4R)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1R,3S,4R)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1R,3S,4R)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1R,3S,4R)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1R,3S,4R)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1R,3S,4R)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1R,3S,4R)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1R,3S,4R)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1S,3R,4S)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1S,3R,4S)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1S,3R,4S)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1S,3R,4S)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1S,3R,4S)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1S,3R,4S)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1S,3R,4S)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1S,3R,4S)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1R,3R,4R)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1R,3R,4R)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1R,3R,4R)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1R,3R,4R)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1R,3R,4R)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-Formamide;

(1R,3R,4R)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-Formamide;

(1R,3R,4R)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1R,3R,4R)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

2-(3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N-(4-fluoro-4-(methylsulfonyl Acyl)-1-(2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-(3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N-((S , E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-nitrogen Heterobicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

4-(2-((3-Chlorophenyl)-D-leucylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamido)- Ethyl 2-fluoro-5-(2-oxopyrrolidin-3-yl)pent-2-enoate;

(S,Z)-4-((1S,3S,4S)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,Z)-4-((1S,3S,4S)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,Z)-4-((1S,3S,4S)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,Z)-4-((1S,3S,4S)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,Z)-4-((1R,3S,4R)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,Z)-4-((1R,3S,4R)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,Z)-4-((1R,3S,4R)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,Z)-4-((1R,3S,4R)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,Z)-4-((1S,3R,4S)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,Z)-4-((1S,3R,4S)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,Z)-4-((1S,3R,4S)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,Z)-4-((1S,3R,4S)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,Z)-4-((1R,3R,4R)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,Z)-4-((1R,3R,4R)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,Z)-4-((1R,3R,4R)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,Z)-4-((1R,3R,4R)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,E)-4-((1S,3S,4S)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,E)-4-((1S,3S,4S)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,E)-4-((1S,3S,4S)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,E)-4-((1S,3S,4S)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,E)-4-((1R,3S,4R)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,E)-4-((1R,3S,4R)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,E)-4-((1R,3S,4R)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,E)-4-((1R,3S,4R)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,E)-4-((1S,3R,4S)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,E)-4-((1S,3R,4S)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,E)-4-((1S,3R,4S)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,E)-4-((1S,3R,4S)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,E)-4-((1R,3R,4R)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,E)-4-((1R,3R,4R)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,E)-4-((1R,3R,4R)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,E)-4-((1R,3R,4R)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,Z)-4-((1S,3S,4S)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,Z)-4-((1S,3S,4S)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,Z)-4-((1S,3S,4S)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,Z)-4-((1S,3S,4S)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,Z)-4-((1R,3S,4R)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,Z)-4-((1R,3S,4R)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,Z)-4-((1R,3S,4R)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,Z)-4-((1R,3S,4R)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,Z)-4-((1S,3R,4S)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,Z)-4-((1S,3R,4S)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,Z)-4-((1S,3R,4S)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,Z)-4-((1S,3R,4S)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,Z)-4-((1R,3R,4R)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,Z)-4-((1R,3R,4R)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,Z)-4-((1R,3R,4R)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,Z)-4-((1R,3R,4R)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,E)-4-((1S,3S,4S)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,E)-4-((1S,3S,4S)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,E)-4-((1S,3S,4S)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,E)-4-((1S,3S,4S)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,E)-4-((1R,3S,4R)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,E)-4-((1R,3S,4R)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,E)-4-((1R,3S,4R)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,E)-4-((1R,3S,4R)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,E)-4-((1S,3R,4S)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,E)-4-((1S,3R,4S)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,E)-4-((1S,3R,4S)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,E)-4-((1S,3R,4S)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,E)-4-((1R,3R,4R)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,E)-4-((1R,3R,4R)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,E)-4-((1R,3R,4R)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,E)-4-((1R,3R,4R)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

4-(2-(3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2] Octane-3-formamido)-2-fluoro-5-(2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,Z)-4-((1S,3S,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,Z)-4-((1S,3S,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,Z)-4-((1S,3S,4S)-2-((R)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,Z)-4-((1S,3S,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,Z)-4-((1R,3S,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,Z)-4-((1R,3S,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,Z)-4-((1R,3S,4R)-2-((R)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,Z)-4-((1R,3S,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,Z)-4-((1S,3R,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,Z)-4-((1S,3R,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,Z)-4-((1S,3R,4S)-2-((R)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,Z)-4-((1S,3R,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,Z)-4-((1R,3R,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,Z)-4-((1R,3R,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,Z)-4-((1R,3R,4R)-2-((R)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,Z)-4-((1R,3R,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,E)-4-((1S,3S,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,E)-4-((1S,3S,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,E)-4-((1S,3S,4S)-2-((R)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,E)-4-((1S,3S,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,E)-4-((1R,3S,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,E)-4-((1R,3S,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,E)-4-((1R,3S,4R)-2-((R)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,E)-4-((1R,3S,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,E)-4-((1S,3R,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,E)-4-((1S,3R,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,E)-4-((1S,3R,4S)-2-((R)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,E)-4-((1S,3R,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,E)-4-((1R,3R,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,E)-4-((1R,3R,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,E)-4-((1R,3R,4R)-2-((R)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,E)-4-((1R,3R,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,Z)-4-((1S,3S,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,Z)-4-((1S,3S,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,Z)-4-((1S,3S,4S)-2-((R)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,Z)-4-((1S,3S,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,Z)-4-((1R,3S,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,Z)-4-((1R,3S,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,Z)-4-((1R,3S,4R)-2-((R)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,Z)-4-((1R,3S,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,Z)-4-((1S,3R,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,Z)-4-((1S,3R,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,Z)-4-((1S,3R,4S)-2-((R)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,Z)-4-((1S,3R,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,Z)-4-((1R,3R,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,Z)-4-((1R,3R,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,Z)-4-((1R,3R,4R)-2-((R)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,Z)-4-((1R,3R,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,E)-4-((1S,3S,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,E)-4-((1S,3S,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,E)-4-((1S,3S,4S)-2-((R)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,E)-4-((1S,3S,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,E)-4-((1R,3S,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,E)-4-((1R,3S,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,E)-4-((1R,3S,4R)-2-((R)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,E)-4-((1R,3S,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,E)-4-((1S,3R,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,E)-4-((1S,3R,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,E)-4-((1S,3R,4S)-2-((R)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,E)-4-((1S,3R,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,E)-4-((1R,3R,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,E)-4-((1R,3R,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,E)-4-((1R,3R,4R)-2-((R)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,E)-4-((1R,3R,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-(4-fluoro-4-(methylsulfonyl)-1-(2-oxo Pyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((S,E)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1S,3S,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((S,E)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1S,3S,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1S,3S,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1S,3S,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((R,E)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1S,3S,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((R,E)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1S,3S,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1S,3S,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1R,3S,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((S,E)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1R,3S,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((S,E)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1R,3S,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1R,3S,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1R,3S,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((R,E)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1R,3S,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((R,E)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1R,3S,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1R,3S,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1S,3R,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((S,E)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1S,3R,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((S,E)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1S,3R,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1S,3R,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1S,3R,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((R,E)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1S,3R,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((R,E)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1S,3R,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1S,3R,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1R,3R,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((S,E)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1R,3R,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((S,E)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1R,3R,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1R,3R,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1R,3R,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((R,E)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1R,3R,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((R,E)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1R,3R,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1R,3R,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-(4-fluoro-4-(methylsulfonyl)-1-(2-oxopyrrolidine-3 -yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1S,3S,4S)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1S,3S,4S)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1S,3S,4S)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1S,3S,4S)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1S,3S,4S)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1S,3S,4S)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1S,3S,4S)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1R,3S,4R)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1R,3S,4R)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1R,3S,4R)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1R,3S,4R)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1R,3S,4R)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1R,3S,4R)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1R,3S,4R)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1R,3S,4R)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1S,3R,4S)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1S,3R,4S)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1S,3R,4S)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1S,3R,4S)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1S,3R,4S)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1S,3R,4S)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1S,3R,4S)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1S,3R,4S)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1R,3R,4R)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1R,3R,4R)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1R,3R,4R)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1R,3R,4R)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1R,3R,4R)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1R,3R,4R)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1R,3R,4R)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1R,3R,4R)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

8-(4-fluoro-1H-indole-2-carbonyl)-N-(4-fluoro-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl )-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide;

8-(4-fluoro-1H-indole-2-carbonyl)-N-((S)-4-fluoro-3-oxo-1-((S)-2-oxopyrrolidine-3- Base) butane-2-yl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide;

(S)-8-(4-fluoro-1H-indole-2-carbonyl)-N-((S)-4-fluoro-3-oxo-1-((S)-2-oxopyrrole Pyridin-3-yl)butan-2-yl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide;

(S)-8-(4-fluoro-1H-indole-2-carbonyl)-N-((S)-4-fluoro-3-oxo-1-((R)-2-oxopyrrole Pyridin-3-yl)butan-2-yl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide;

(S)-8-(4-fluoro-1H-indole-2-carbonyl)-N-((R)-4-fluoro-3-oxo-1-((S)-2-oxopyrrole Pyridin-3-yl)butan-2-yl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide;

(S)-8-(4-fluoro-1H-indole-2-carbonyl)-N-((R)-4-fluoro-3-oxo-1-((R)-2-oxopyrrole Pyridin-3-yl)butan-2-yl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide;

(R)-8-(4-fluoro-1H-indole-2-carbonyl)-N-((S)-4-fluoro-3-oxo-1-((S)-2-oxopyrrole Pyridin-3-yl)butan-2-yl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide;

(R)-8-(4-fluoro-1H-indole-2-carbonyl)-N-((S)-4-fluoro-3-oxo-1-((R)-2-oxopyrrole Pyridin-3-yl)butan-2-yl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide;

(R)-8-(4-fluoro-1H-indole-2-carbonyl)-N-((R)-4-fluoro-3-oxo-1-((S)-2-oxopyrrole Pyridin-3-yl)butan-2-yl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide;

(R)-8-(4-fluoro-1H-indole-2-carbonyl)-N-((R)-4-fluoro-3-oxo-1-((R)-2-oxopyrrole Pyridin-3-yl)butan-2-yl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide;

8-(7-Chloro-1H-indole-2-carbonyl)-N-(4-fluoro-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl )-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide;

8-(7-Chloro-1H-indole-2-carbonyl)-N-((S)-4-fluoro-3-oxo-1-((S)-2-oxopyrrolidine-3- Base) butane-2-yl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide;

(S)-8-(7-chloro-1H-indole-2-carbonyl)-N-((S)-4-fluoro-3-oxo-1-((S)-2-oxopyrrole Pyridin-3-yl)butan-2-yl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide;

(S)-8-(7-chloro-1H-indole-2-carbonyl)-N-((S)-4-fluoro-3-oxo-1-((R)-2-oxopyrrole Pyridin-3-yl)butan-2-yl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide;

(S)-8-(7-chloro-1H-indole-2-carbonyl)-N-((R)-4-fluoro-3-oxo-1-((S)-2-oxopyrrole Pyridin-3-yl)butan-2-yl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide;

(S)-8-(7-chloro-1H-indole-2-carbonyl)-N-((R)-4-fluoro-3-oxo-1-((R)-2-oxopyrrole Pyridin-3-yl)butan-2-yl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide;

(R)-8-(7-chloro-1H-indole-2-carbonyl)-N-((S)-4-fluoro-3-oxo-1-((S)-2-oxopyrrole Pyridin-3-yl)butan-2-yl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide;

(R)-8-(7-chloro-1H-indole-2-carbonyl)-N-((S)-4-fluoro-3-oxo-1-((R)-2-oxopyrrole Pyridin-3-yl)butan-2-yl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide;

(R)-8-(7-chloro-1H-indole-2-carbonyl)-N-((R)-4-fluoro-3-oxo-1-((S)-2-oxopyrrole Pyridin-3-yl)butan-2-yl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide;

(R)-8-(7-chloro-1H-indole-2-carbonyl)-N-((R)-4-fluoro-3-oxo-1-((R)-2-oxopyrrole Pyridin-3-yl)butan-2-yl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide;

2-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-5,5-difluoro-N-(4-fluoro-3-oxo-1-(2-oxo Pyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-5,5-difluoro-N-((S)-4-fluoro- 3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1S,3S,4S)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-5,5-difluoro-N-((S)-4-fluoro- 3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1S,3S,4S)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-5,5-difluoro-N-((R)-4-fluoro- 3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1S,3S,4S)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-5,5-difluoro-N-((R)-4-fluoro- 3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1R,3S,4R)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-5,5-difluoro-N-((S)-4-fluoro- 3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1R,3S,4R)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-5,5-difluoro-N-((S)-4-fluoro- 3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1R,3S,4R)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-5,5-difluoro-N-((R)-4-fluoro- 3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1R,3S,4R)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-5,5-difluoro-N-((R)-4-fluoro- 3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1S,3R,4S)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-5,5-difluoro-N-((S)-4-fluoro- 3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1S,3R,4S)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-5,5-difluoro-N-((S)-4-fluoro- 3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1S,3R,4S)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-5,5-difluoro-N-((R)-4-fluoro- 3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1S,3R,4S)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-5,5-difluoro-N-((R)-4-fluoro- 3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1R,3R,4R)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-5,5-difluoro-N-((S)-4-fluoro- 3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1R,3R,4R)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-5,5-difluoro-N-((S)-4-fluoro- 3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1R,3R,4R)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-5,5-difluoro-N-((R)-4-fluoro- 3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1R,3R,4R)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-5,5-difluoro-N-((R)-4-fluoro- 3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

2-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-N-(4-fluoro-3-oxo-1-(2-oxopyrrolidin-3-yl) )butane-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-N-((S)-4-fluoro-3-oxo-1 -((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-N-((S)-4-fluoro-3-oxo-1 -((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-N-((R)-4-fluoro-3-oxo-1 -((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-N-((R)-4-fluoro-3-oxo-1 -((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-N-((S)-4-fluoro-3-oxo-1 -((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-N-((S)-4-fluoro-3-oxo-1 -((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-N-((R)-4-fluoro-3-oxo-1 -((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-N-((R)-4-fluoro-3-oxo-1 -((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-N-((S)-4-fluoro-3-oxo-1 -((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-N-((S)-4-fluoro-3-oxo-1 -((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-N-((R)-4-fluoro-3-oxo-1 -((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-N-((R)-4-fluoro-3-oxo-1 -((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-N-((S)-4-fluoro-3-oxo-1 -((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-N-((S)-4-fluoro-3-oxo-1 -((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-N-((R)-4-fluoro-3-oxo-1 -((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-N-((R)-4-fluoro-3-oxo-1 -((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

2-(2-(3-fluorophenyl)-2,2-difluoroacetyl)-N-(4-fluoro-3-oxo-1-(2-oxopyrrolidin-3-yl) )butane-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-(2-(3-fluorophenyl)-2,2-difluoroacetyl)-N-((S)-4-fluoro-3-oxo-1 -((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-(2-(3-fluorophenyl)-2,2-difluoroacetyl)-N-((S)-4-fluoro-3-oxo-1 -((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-(2-(3-fluorophenyl)-2,2-difluoroacetyl)-N-((R)-4-fluoro-3-oxo-1 -((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-(2-(3-fluorophenyl)-2,2-difluoroacetyl)-N-((R)-4-fluoro-3-oxo-1 -((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-(2-(3-fluorophenyl)-2,2-difluoroacetyl)-N-((S)-4-fluoro-3-oxo-1 -((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-(2-(3-fluorophenyl)-2,2-difluoroacetyl)-N-((S)-4-fluoro-3-oxo-1 -((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-(2-(3-fluorophenyl)-2,2-difluoroacetyl)-N-((R)-4-fluoro-3-oxo-1 -((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-(2-(3-fluorophenyl)-2,2-difluoroacetyl)-N-((R)-4-fluoro-3-oxo-1 -((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-(2-(3-fluorophenyl)-2,2-difluoroacetyl)-N-((S)-4-fluoro-3-oxo-1 -((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-(2-(3-fluorophenyl)-2,2-difluoroacetyl)-N-((S)-4-fluoro-3-oxo-1 -((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-(2-(3-fluorophenyl)-2,2-difluoroacetyl)-N-((R)-4-fluoro-3-oxo-1 -((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-(2-(3-fluorophenyl)-2,2-difluoroacetyl)-N-((R)-4-fluoro-3-oxo-1 -((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-(2-(3-fluorophenyl)-2,2-difluoroacetyl)-N-((S)-4-fluoro-3-oxo-1 -((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-(2-(3-fluorophenyl)-2,2-difluoroacetyl)-N-((S)-4-fluoro-3-oxo-1 -((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-(2-(3-fluorophenyl)-2,2-difluoroacetyl)-N-((R)-4-fluoro-3-oxo-1 -((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-(2-(3-fluorophenyl)-2,2-difluoroacetyl)-N-((R)-4-fluoro-3-oxo-1 -((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

2-(2-Fluoro-2-(3-fluorophenyl)propionyl)-N-(4-fluoro-3-oxo-1-(2-oxopyrrolidin-3-yl)butane -2-yl) octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-(2-fluoro-2-(3-fluorophenyl)propionyl)-N-((S)-4-fluoro-3-oxo-1-(( S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((S)-4-fluoro-3-oxo- 1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((S)-4-fluoro-3-oxo- 1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((R)-4-fluoro-3-oxo- 1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((R)-4-fluoro-3-oxo- 1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((S)-4-fluoro-3-oxo- 1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((S)-4-fluoro-3-oxo- 1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((R)-4-fluoro-3-oxo- 1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((R)-4-fluoro-3-oxo- 1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((S)-4-fluoro-3-oxo- 1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((S)-4-fluoro-3-oxo- 1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((R)-4-fluoro-3-oxo- 1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((R)-4-fluoro-3-oxo- 1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((S)-4-fluoro-3-oxo- 1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((S)-4-fluoro-3-oxo- 1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((R)-4-fluoro-3-oxo- 1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((R)-4-fluoro-3-oxo- 1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((S)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((S)-4-fluoro-3-oxo- 1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((S)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((S)-4-fluoro-3-oxo- 1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((S)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((R)-4-fluoro-3-oxo- 1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((S)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((R)-4-fluoro-3-oxo- 1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((S)-4-fluoro-3-oxo- 1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((S)-4-fluoro-3-oxo- 1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((R)-4-fluoro-3-oxo- 1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((R)-4-fluoro-3-oxo- 1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((S)-4-fluoro-3-oxo- 1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((S)-4-fluoro-3-oxo- 1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((R)-4-fluoro-3-oxo- 1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((R)-4-fluoro-3-oxo- 1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((S)-4-fluoro-3-oxo- 1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((S)-4-fluoro-3-oxo- 1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((R)-4-fluoro-3-oxo- 1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((R)-4-fluoro-3-oxo- 1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-(1-(2-oxodihydrofuran-3(2H)-ylidene)- 3-(2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((S,E)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((S)-2-oxopyrrolidin-3-yl)propane-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1S,3S,4S)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((S,E)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((R)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1S,3S,4S)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((S,Z)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((S)-2-oxopyrrolidin-3-yl)propane-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1S,3S,4S)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((S,Z)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((R)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1S,3S,4S)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((R,E)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((S)-2-oxopyrrolidin-3-yl)propane-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1S,3S,4S)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((R,E)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((R)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1S,3S,4S)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((R,Z)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1S,3S,4S)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((R,Z)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((R)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1R,3S,4R)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((S,E)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((S)-2-oxopyrrolidin-3-yl)propane-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1R,3S,4R)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((S,E)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((R)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1R,3S,4R)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((S,Z)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1R,3S,4R)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((S,Z)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((R)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1R,3S,4R)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((R,E)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((S)-2-oxopyrrolidin-3-yl)propane-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1R,3S,4R)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((R,E)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((R)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1R,3S,4R)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((R,Z)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((S)-2-oxopyrrolidin-3-yl)propane-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1R,3S,4R)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((R,Z)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((R)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1S,3R,4S)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((S,E)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1S,3R,4S)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((S,E)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((R)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1S,3R,4S)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((S,Z)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((S)-2-oxopyrrolidin-3-yl)propane-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1S,3R,4S)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((S,Z)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((R)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1S,3R,4S)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((R,E)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1S,3R,4S)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((R,E)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((R)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1S,3R,4S)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((R,Z)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((S)-2-oxopyrrolidin-3-yl)propane-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1S,3R,4S)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((R,Z)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((R)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1R,3R,4R)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((S,E)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((S)-2-oxopyrrolidin-3-yl)propane-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1R,3R,4R)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((S,E)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((R)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1R,3R,4R)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((S,Z)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1R,3R,4R)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((S,Z)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((R)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1R,3R,4R)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((R,E)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1R,3R,4R)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((R,E)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((R)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1R,3R,4R)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((R,Z)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1R,3R,4R)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((R,Z)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((R)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

2-(2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-5,5- Difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-(2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((S)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((S)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((S)-2-Bromo-9-hydroxyl-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((S)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((R)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((R)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((R)-2-Bromo-9-hydroxyl-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((R)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((S)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((S)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((S)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((S)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((R)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((R)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((R)-2-Bromo-9-hydroxyl-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((R)-2-Bromo-9-hydroxyl-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((S)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((S)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((S)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((S)-2-Bromo-9-hydroxyl-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((R)-2-Bromo-9-hydroxyl-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((R)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((R)-2-Bromo-9-hydroxyl-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((R)-2-Bromo-9-hydroxyl-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((S)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((S)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((S)-2-Bromo-9-hydroxyl-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((S)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((R)-2-Bromo-9-hydroxyl-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((R)-2-Bromo-9-hydroxyl-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((R)-2-bromo-9-hydroxyl-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((R)-2-bromo-9-hydroxyl-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-2-(2,7-difluoro-9-hydroxy-9H-fennel-9-carbonyl)-5 ,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1S,3S,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Fluoro-9-hydroxy-9H-fluorene-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Fluoro-9-hydroxy-9H-fluorene-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Fluoro-9-hydroxy-9H-fluorene-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Fluoro-9-hydroxy-9H-fluorene-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Fluoro-9-hydroxy-9H-fluorene-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Fluoro-9-hydroxy-9H-fluorene-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Fluoro-9-hydroxy-9H-fluorene-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Fluoro-9-hydroxy-9H-fluorene-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Fluoro-9-hydroxy-9H-fluorene-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Fluoro-9-hydroxy-9H-fluorene-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Fluoro-9-hydroxy-9H-fluorene-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Fluoro-9-hydroxy-9H-fluorene-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Fluoro-9-hydroxy-9H-fluorene-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Fluoro-9-hydroxy-9H-fluorene-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Fluoro-9-hydroxy-9H-fluorene-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Fluoro-9-hydroxy-9H-fluorene-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-2-(2,7-dichloro-9-hydroxy-9H-fennel-9-carbonyl)-5 ,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1S,3S,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Chloro-9-hydroxy-9H-fennel-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Chloro-9-hydroxy-9H-fennel-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Chloro-9-hydroxy-9H-fennel-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Chloro-9-hydroxy-9H-fennel-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Chloro-9-hydroxy-9H-fennel-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Chloro-9-hydroxy-9H-fennel-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Chloro-9-hydroxy-9H-fennel-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Chloro-9-hydroxy-9H-fennel-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Chloro-9-hydroxy-9H-fennel-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Chloro-9-hydroxy-9H-fennel-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Chloro-9-hydroxy-9H-fennel-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Chloro-9-hydroxy-9H-fennel-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Chloro-9-hydroxy-9H-fennel-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Chloro-9-hydroxy-9H-fennel-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Chloro-9-hydroxy-9H-fennel-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Chloro-9-hydroxy-9H-fennel-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-(9-hydroxy-9H-fennel-9-carbonyl)octahydro Cyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-(4-fluoro-1H-indole-2-carbonyl)eta Hydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(4-fluoro-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(4-fluoro-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(4-fluoro-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(4-fluoro-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(4-fluoro-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(4-fluoro-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(4-fluoro-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(4-fluoro-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(4-fluoro-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(4-fluoro-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(4-fluoro-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(4-fluoro-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(4-fluoro-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(4-fluoro-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(4-fluoro-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(4-fluoro-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoromethyl)-6-fluoro-1H-indole-2-carbonyl )-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoromethyl)-7-chloro-1H-indole-2-carbonyl )-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-2-(4,7-difluoro-6-chloro-1H-indole-2-carbonyl)- 5,5-Difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

2-(3-Chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl) -5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-(3-Chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-1-cyano-2-((S )-2-oxopiperidin-3-yl)ethyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-(3-Chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-1-cyano-2-((R )-2-oxopiperidin-3-yl)ethyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-1-cyano-2-((S )-2-oxopiperidin-3-yl)ethyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-1-cyano-2-((R )-2-oxopiperidin-3-yl)ethyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-(3-Chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-1-cyano-2-((S )-2-oxopiperidin-3-yl)ethyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-(3-Chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-1-cyano-2-((R )-2-oxopiperidin-3-yl)ethyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-1-cyano-2-((S )-2-oxopiperidin-3-yl)ethyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-(3-Chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-1-cyano-2-((R )-2-oxopiperidin-3-yl)ethyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-1-cyano-2-((S )-2-oxopiperidin-3-yl)ethyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-1-cyano-2-((R )-2-oxopiperidin-3-yl)ethyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-1-cyano-2-((S )-2-oxopiperidin-3-yl)ethyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-1-cyano-2-((R )-2-oxopiperidin-3-yl)ethyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-1-cyano-2-((S )-2-oxopiperidin-3-yl)ethyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-1-cyano-2-((R )-2-oxopiperidin-3-yl)ethyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-1-cyano-2-((S )-2-oxopiperidin-3-yl)ethyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-1-cyano-2-((R )-2-oxopiperidin-3-yl)ethyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-2-(4,6-difluoro-7-chloro-1H-indole-2-carbonyl)- 5,5-Difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,6-di Fluoro-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,6-di Fluoro-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,6-di Fluoro-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,6-di Fluoro-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,6-di Fluoro-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,6-di Fluoro-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,6-di Fluoro-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,6-di Fluoro-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,6-di Fluoro-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,6-di Fluoro-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,6-di Fluoro-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,6-di Fluoro-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,6-di Fluoro-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,6-di Fluoro-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,6-di Fluoro-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,6-di Fluoro-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-6-methyl-7-chloro-1H-indole-2-carbonyl )-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-6 -Methyl-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-6 -Methyl-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-6 -Methyl-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-6 -Methyl-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-6 -Methyl-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-6 -Methyl-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-6 -Methyl-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-6 -Methyl-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-6 -Methyl-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-6 -Methyl-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-6 -Methyl-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-6 -Methyl-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-6 -Methyl-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-6 -Methyl-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-6 -Methyl-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-6 -Methyl-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-2-(4,7-difluoro-6-methyl-1H-indole-2-carbonyl) -5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-methyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-methyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-methyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-methyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-methyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-methyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-methyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-methyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-methyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-methyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-methyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-methyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-methyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-methyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-methyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-methyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-7-difluoromethyl-1H-indole-2-carbonyl)- 5,5-Difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-7 -Difluoromethyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-7 -Difluoromethyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-7 -Difluoromethyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-7 -Difluoromethyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-7 -Difluoromethyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-7 -Difluoromethyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-7 -Difluoromethyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-7 -Difluoromethyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-7 -Difluoromethyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-7 -Difluoromethyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-7 -Difluoromethyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-7 -Difluoromethyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-7 -Difluoromethyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-7 -Difluoromethyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-7 -Difluoromethyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-7 -Difluoromethyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

N-(1-cyano-2-(2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy-1H-indole-2-carbonyl)-5,5-di Fluoroctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy -1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy -1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy -1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy -1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy -1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy -1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy -1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy -1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy -1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy -1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy -1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy -1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy -1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy -1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy -1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy -1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-4,4-difluoro-2-(9-hydroxy-9H-fennel-9-carbonyl)octahydro Cyclopenta[c]pyrrole-1-carboxamide;

N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-4,4-difluoro-2-(9-hydroxyl-9H- Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

N-(1-cyano-2-(2-oxopyrrolidin-3-yl)ethyl)-4,4-difluoro-2-(9-hydroxy-9H-fennel-9-carbonyl)octahydro Cyclopenta[c]pyrrole-1-carboxamide;

N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-4,4-difluoro-2-(9-hydroxyl-9H- Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-2-(9-hydroxy-9H-fenflure-9-carbonyl)octahydrocyclopenta[c]pyrrole- 1-formamide;

N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(9-hydroxyl-9H-fennel-9-carbonyl)octa Hydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(9-hydroxyl-9H -Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(9-hydroxyl-9H -Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(9-hydroxyl-9H -Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(9-hydroxyl-9H -Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(9-hydroxyl-9H -Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(9-hydroxyl-9H -Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(9-hydroxyl-9H -Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(9-hydroxyl-9H -Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(9-hydroxyl-9H -Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(9-hydroxyl-9H -Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(9-hydroxyl-9H -Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(9-hydroxyl-9H -Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(9-hydroxyl-9H -Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(9-hydroxyl-9H -Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(9-hydroxyl-9H -Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; and

(1R,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(9-hydroxyl-9H -Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide.

Compounds of the disclosure may possess one or more stereocenters, and each stereocenter may independently exist in the ( R ) or ( S ) configuration. In certain embodiments, the compounds described herein exist in optically active or racemic forms. The compounds described herein include racemic, optical, regioisomeric and stereoisomeric forms or combinations thereof that possess the therapeutically useful properties described herein. Preparation of optically active forms is achieved in any suitable manner including, by way of non-limiting examples, resolution of racemic forms using recrystallization techniques, synthesis from optically active starting materials, chiral synthesis or chromatographic separation using chiral stationary phases. Compounds described herein by racemic formula further represent both enantiomers or mixtures thereof, or where two or more chiral centers are present, all diastereomers or mixtures thereof.

In certain embodiments, compounds of the disclosure exist as tautomers. All tautomers are included within the scope of the compounds described herein.

Compounds described herein also include isotopically labeled compounds in which one or more atoms are replaced by atoms having the same atomic number but an atomic mass or atomic mass number different from that normally found in nature. Examples of isotopes suitable for inclusion in the compounds described herein include, but are not limited to ^{, 2H} , ^3H , ^11C , ^13C , ^{14C ,} 36Cl, ^18F , ^123I , ^125I , ^13N , ^15N , ¹⁵ O, ¹⁷ O, ¹⁸ O, ³² P and ³⁵ S. In certain embodiments, substitution with heavier isotopes such as deuterium provides greater chemical stability. Isotopically labeled compounds may be prepared by any suitable method or method using a suitable isotopically labeled reagent instead of an otherwise unlabeled reagent.

In certain embodiments, the compounds described herein are labeled by other means including, but not limited to, the use of chromophores or fluorescent moieties, bioluminescent labels, or chemiluminescent labels.

In all of the embodiments provided herein, examples of suitable optional substituents are not intended to limit the scope of the claimed invention. Compounds of the disclosure may contain any substituent or combination of substituents provided herein.

Salt

The compounds described herein may form salts with acids or alkalis, and such salts are included in this disclosure. The term "salt" includes free acid or alkali addition salts useful in the methods of the present disclosure. The term "pharmaceutically acceptable salt" refers to a salt having a toxicity profile within the range useful in pharmaceutical use. In certain embodiments, the salt is a pharmaceutically acceptable salt. However, pharmaceutically unacceptable salts may have properties such as high crystallinity, which have utility in the practice of the present disclosure, such as, for example, during the synthesis, purification, or formulation of compounds useful in the methods of the present disclosure. practicality.

Suitable pharmaceutically acceptable acid addition salts can be prepared from inorganic or organic acids. Examples of the inorganic acid include sulfate, hydrogen sulfate, hydrochloric acid, hydrobromic acid, hydroiodic acid, nitric acid, carbonic acid, sulfuric acid, and phosphoric acid (including hydrogen phosphate and dihydrogen phosphate). Suitable organic acids may be selected from aliphatic, cycloaliphatic, aromatic, araliphatic, heterocyclic, carboxylic and sulfonic acids, examples of which include formic acid, acetic acid, propionic acid, succinic acid, glycolic acid, glucose Sugar acid, lactic acid, malic acid, tartaric acid, citric acid, ascorbic acid, glucuronic acid, maleic acid, fumaric acid, pyruvic acid, aspartic acid, glutamic acid, benzoic acid, anthranilic acid, 4 -Hydroxybenzoic acid, phenylacetic acid, mandelic acid, pamoic acid (or pamoic acid), methanesulfonic acid, ethanesulfonic acid, benzenesulfonic acid, pantothenic acid, sulfanilic acid, 2-hydroxyethanesulfonic acid, trifluoromethanesulfonic acid, p-toluenesulfonic acid, cyclamate, stearic acid, alginic acid, β-hydroxybutyric acid, salicylic acid, galactaric acid, semi Lacturonic acid, glycerylphosphonic acid, and saccharin (eg, saccharinate, saccharate). A salt may consist of 1, 1, or more than 1 molar equivalent of the acid or alkali moiety relative to any compound of the disclosure.

Suitable pharmaceutically acceptable alkali addition salts of the compounds of the disclosure include, for example, ammonium salts and metal salts, including alkali metal, alkaline earth metal and transition metal salts, such as, for example, calcium, magnesium, potassium, sodium and zinc salts. Pharmaceutically acceptable alkali addition salts also include those formed from basic amines such as, for example, N , N' -dibenzylethylenediamine, chloroprocaine, choline, diethanolamine, ethylenediamine, meglumine (or N -methylglucamine) and organic salts prepared from procaine. All these salts can be prepared from the corresponding compounds by, for example, reacting the appropriate acid or alkali with the compound.

combination therapy

In one aspect, a compound of the disclosure is used in a method of the disclosure in combination with one or more additional agents for treating a coronavirus infection. These additional agents may include compounds or compositions identified herein, or compounds (eg, commercially available compounds) known to be useful in treating, preventing, or alleviating the symptoms of coronavirus infection.

synthesis

The present disclosure further provides methods of preparing the compounds of the present disclosure. Compounds of the present teachings can be prepared from commercially available starting materials, compounds known in the literature, or readily prepared intermediates by using standard synthetic methods and procedures known to those skilled in the art according to the procedures outlined herein. Standard synthetic methods and procedures for the preparation of organic molecules and functional group transformations and manipulations are readily available from the relevant scientific literature or standard textbooks in the field.

It should be understood that where typical or preferred process conditions (ie, reaction temperatures, times, molar ratios of reactants, solvents, pressures, etc.) are given, other process conditions can also be used unless otherwise stated. Optimum reaction conditions may vary with the particular reactants or solvent used, but such conditions can be determined by one skilled in the art by routine optimization procedures. Certainly. Those skilled in the art of organic synthesis will recognize that the nature and order of the synthetic steps presented can be varied for the purpose of optimizing the formation of the compounds described herein.

The processes described herein can be monitored according to any suitable method known in the art. For example, product formation can be by spectroscopic means, such as nuclear magnetic resonance spectroscopy (e.g., ¹ H or ¹³ C), infrared spectroscopy, spectrophotometry (e.g., UV-visible), mass spectrometry, or by chromatographic methods such as High pressure liquid chromatography (HPLC), gas chromatography (GC), gel permeation chromatography (GPC) or thin layer chromatography (TLC) to monitor.

Preparation of compounds may involve protection and deprotection of various chemical groups. The need for protection and deprotection and the selection of suitable protecting groups can be readily determined by those skilled in the art. The chemistry of protecting groups can be found, for example, in Greene et al., Protective Groups in Organic Synthesis, 2nd Ed. (Wiley & Sons, 1991), the entire disclosure of which is incorporated herein by reference for all purposes.

The reactions or methods described herein can be carried out in suitable solvents which can be readily selected by those skilled in the art of organic synthesis. Suitable solvents are generally substantially nonreactive with the reactants, intermediates and/or products at the temperatures at which the reactions are carried out, ie, temperatures ranging from the solvent's freezing temperature to the solvent's boiling temperature. A given reaction can be carried out in one solvent or a mixture of more than one solvent. Depending on the particular reaction step, a suitable solvent for a particular reaction step can be selected.

For example, compounds of formula (I), wherein each occurrence of R, R' and R" are independently selected from H, optionally substituted C ₁ -C _{6 ,} can be prepared according to the synthetic methods outlined in Schemes 1-21 Alkyl, optionally substituted C ₁ -C ₆ cycloalkyl, optionally substituted phenyl, optionally substituted benzyl and optionally substituted C ₂ -C ₉ heterocyclyl; Ar is selected from Optionally substituted C ₂ -C ₉ heteroaryl, optionally substituted phenyl and optionally substituted naphthyl; A ¹ is CR ^a2 or N; A ² is CR ^a3 or N; A ³ is CR ^a6 or N; ^A4 is CR ^a7 or N; T is a leaving group selected from Cl, Br, OMs; _G1 and _G2 are defined within the range of ^R1 ; n is selected from 0, 1 and 2 integer; and where all other substituents are defined within the scope of this disclosure.

Process 5.

Process 16.

method

The compounds described herein are useful for treating, preventing and/or ameliorating infections caused by one or more coronaviruses (non-limiting examples include alphacoronaviruses, betacoronaviruses, gammacoronaviruses, and deltacoronaviruses).

In certain embodiments, alphacoronaviruses include, but are not limited to, alphacoronaviruses 1 (e.g., transmissible gastroenteritis virus (TGEV), feline coronavirus (FCoV), and canine coronavirus (CCoV), human coronavirus 229E ( HCoV-229E), human coronavirus NL63 (HCoV-NL63), long-winged bat coronavirus 1, long-winged bat coronavirus HKU8, porcine epidemic diarrhea virus (PEDV), porcine acute diarrhea syndrome coronavirus (SADS-CoV) , Chrysanthemum bat coronavirus HKU2 and yellow bat coronavirus 512.

In certain embodiments, betacoronaviruses include, but are not limited to, betacoronavirus 1 (e.g., bovine coronavirus and human coronavirus OC43 (HCoV-OC43)), hedgehog coronavirus 1, human coronavirus HKU1 (HCoV-HKU1) , Middle East Respiratory Syndrome-associated coronavirus (MERS-CoV), Murine coronavirus (M-CoV), Pteropus bat coronavirus HKU5, Fruit bat coronavirus HKU9 (HKU9-1), Severe acute respiratory syndrome-associated coronavirus Virus 1 (SARS-CoV or SARS-CoV-1), severe acute respiratory syndrome-associated coronavirus 2 (SARS-CoV-2), and bat coronavirus HKU4.

In certain embodiments, gamma coronaviruses include, but are not limited to, avian coronaviruses and beluga coronaviruses SW1.

In certain embodiments, deltacoronaviruses include, but are not limited to, Bulbul coronavirus HKU11 and porcine coronavirus HKU15.

In certain embodiments, compounds of the disclosure are active against one or more of SARS-CoV-2, SARS-CoV, MERS-CoV, HCoV-OC43, HCoV-229E, HCoV-HKU1, and HCoV-NL63.

In one aspect, the present disclosure provides a method of treating, ameliorating or preventing a coronavirus infection in a subject, the method comprising administering to the subject a therapeutically effective amount of at least one compound of the present disclosure and/or At least one pharmaceutical composition of the present disclosure.

In certain embodiments, at least one additional agent for treating, ameliorating or preventing coronavirus infection is further administered to the subject. In certain embodiments, at least one compound and/or composition and at least one additional agent are co-administered to a subject. In certain embodiments, at least one additional agent is an inhibitor of RNA-dependent RNA polymerase (RdRp) (ie, nspl2) or a prodrug thereof. In certain embodiments, at least one compound and/or composition and at least one additional agent are co-formulated.

In certain embodiments, the coronavirus is selected from alphacoronaviruses and betacoronaviruses.

In certain embodiments, the alphacoronavirus is human coronavirus 229E (HCoV-229E). In certain embodiments, the alphacoronavirus is human coronavirus NL63 (HCoV-NL63).

In certain embodiments, the betacoronavirus is severe acute respiratory syndrome-associated coronavirus 2 (SARS-CoV-2). In certain embodiments, the betacoronavirus is severe acute respiratory syndrome-associated coronavirus 1 (SARS-CoV or SARS-CoV-1). In certain embodiments, the betacoronavirus is Middle East Respiratory Syndrome-related coronavirus (MERS-CoV). In certain embodiments, the betacoronavirus is human coronavirus OC43 (HCoV-OC43). In certain embodiments, the betacoronavirus is human coronavirus HKU1 (HCoV-HKU1).

In certain embodiments, the coronavirus major protease (M ^pro ) is inhibited. In certain embodiments, M ^pro is a 3C-like protease (3CL ^pro ).

In certain embodiments, the subject is a mammal. In certain embodiments, the mammal is a human.

Pharmaceutical compositions and formulations

The present disclosure provides pharmaceutical compositions comprising at least one compound of the present disclosure, or a salt or solvate thereof, for use in practicing the methods of the present disclosure. Such a pharmaceutical composition may consist of at least one compound of the present disclosure or a salt or solvate thereof in a form suitable for administration to a subject, or the pharmaceutical composition may comprise at least one compound of the present disclosure or a salt or solvate thereof and one or more pharmaceutically acceptable carriers, one or more additional ingredients, or some combination of these. As is well known in the art, at least one compound of the present disclosure may be present in a pharmaceutical composition in the form of a physiologically acceptable salt, such as in combination with a physiologically acceptable cation or anion.

In certain embodiments, a pharmaceutical composition for practicing the methods of the present disclosure can be administered to deliver a dose of between 1 ng/kg/day and 100 mg/kg/day. In other embodiments, the pharmaceutical compositions used to practice the present disclosure can be administered to deliver doses of between 1 ng/kg/day and 1,000 mg/kg/day.

The relative amounts of the active ingredient, the pharmaceutically acceptable carrier, and any additional ingredients in the pharmaceutical compositions of the present disclosure will vary depending on the identity, size and condition of the subject being treated, and It further depends on the route by which the composition is administered. For example, the composition may comprise between 0.1% and 100% (w/w) active ingredient.

Pharmaceutical compositions for use in the methods of the present disclosure may be suitably developed for nasal, inhalational, oral, rectal, vaginal, pleural, peritoneal, parenteral, topical, transdermal, pulmonary, intranasal, buccal, Intraocular, epidural, intrathecal, intravenous or another route of administration. The compositions used in the methods of the present disclosure may be administered directly to the cerebrum, brainstem, or any other part of the central nervous system of a mammal or bird. Other contemplated formulations include projected nanoparticles, microspheres, liposomal formulations, coated particles, polymer conjugates, resealed erythrocytes containing the active ingredient, and immunology-based formulations.

In certain embodiments, compositions of the present disclosure are part of a pharmaceutical matrix, which allows for the manipulation and improvement of bioavailability of insoluble materials, the development of controlled or sustained release products, and the creation of homogeneous compositions. For example, hot melt extrusion, solid solutions, solid dispersions, size reduction techniques, molecular complexes (eg, cyclodextrins, etc.), microparticles, and granule and formulation coating methods can be used to prepare drug matrices. Amorphous or crystalline phases can be used in this process.

The route(s) of administration will be apparent to the skilled artisan and will depend on many factors including the type and severity of the disease being treated, the type and age of the veterinary or human patient being treated, and the like.

Formulations of the pharmaceutical compositions described herein can be prepared by any method known or later developed in the art of pharmacology and pharmacy. In general, such methods of preparation include the steps of bringing into association the active ingredient with the carrier or one or more other accessory ingredients, and then, if necessary or desired, shaping or packaging the product in the desired unit-dose or multi-dose unit.

As used herein, a "unit dose" is a discrete quantity of pharmaceutical composition comprising a predetermined quantity of active ingredient. The amount of active ingredient is usually equal to the active ingredient to be administered to the subject. A dose of the sexual ingredient or a convenient fraction of such a dose, such as, for example, half or a third of such a dose. The unit dosage form can be a single daily dose or one of multiple daily doses (eg, about 1-4 or more times per day). When multiple daily doses are used, the unit dosage form may be the same or different for each administration.

Although the description of pharmaceutical compositions provided herein is primarily directed to pharmaceutical compositions suitable for ethical administration to humans, the skilled artisan will appreciate that such compositions are generally suitable for administration to various animals. Modifications of pharmaceutical compositions suitable for human administration in order to make compositions suitable for administration to various animals are well known and can be devised and performed by a veterinary pharmacologist of ordinary skill only by ordinary experimentation. Subjects to which the pharmaceutical compositions of the disclosure are contemplated include, but are not limited to, humans and other primates, mammals, including commercially relevant mammals such as cattle, pigs, horses, sheep, cats, and dogs .

In certain embodiments, compositions of the present disclosure are formulated using one or more pharmaceutically acceptable excipients or carriers. In certain embodiments, pharmaceutical compositions of the present disclosure include a therapeutically effective amount of at least one compound of the present disclosure and a pharmaceutically acceptable carrier. Useful pharmaceutically acceptable carriers include, but are not limited to, glycerol, water, saline, ethanol, recombinant human albumin (e.g., Recombumin®), soluble gels (e.g., Gelofusine®), and other pharmaceutically acceptable salts Solutions such as phosphates and salts of organic acids. Examples of these and other pharmaceutically acceptable carriers are described in Remington's Pharmaceutical Sciences (1991, Mack Publication Co., New Jersey).

The carrier can be a solvent or dispersion medium containing, for example, water, ethanol, polyol (eg, glycerol, propylene glycol, and liquid polyethylene glycol, and the like), recombinant human albumin, soluble gelatin, suitable mixtures thereof, and vegetable oils. For example, proper fluidity can be maintained by the use of coatings such as lecithin, by maintaining the desired particle size in the presence of dispersions, and by the use of surfactants. Prevention of the action of microorganisms can be prevented by various antibacterial and antifungal agents, for example, parabens, chlorobutanol, phenol, ascorbic acid, thimerosal, and the like. In many cases, the composition includes isotonic agents, such as sugars, sodium chloride, or polyols, Such as mannitol and sorbitol. Prolonged absorption of the injectable compositions can be brought about by including in the composition an agent which delays absorption, for example, aluminum monostearate or gelatin.

The formulations may be used in admixture with conventional excipients, i.e., pharmaceutically acceptable formulations suitable for oral, parenteral, nasal, inhalation, intravenous, subcutaneous, transdermal enteral or any other suitable mode of administration known in the art. organic or inorganic carrier substances. The pharmaceutical preparations can be sterilized and, if desired, mixed with auxiliary agents such as lubricants, preservatives, stabilizers, wetting agents, emulsifiers, salts for influencing osmotic pressure buffers, colorants, flavorings and/or Aroma-imparting substances and the like are mixed. They can also be combined, if desired, with other active agents, for example other analgesics, anxiolytics or hypnotics. As used herein, "an additional ingredient" includes, but is not limited to, one or more ingredients that can be used as a pharmaceutical carrier.

Compositions of the present disclosure may include from about 0.005% to 2.0% of a preservative, based on the total weight of the composition. Preservatives are used to prevent spoilage in case of exposure to pollutants in the environment. Examples of preservatives useful in accordance with the present disclosure include, but are not limited to, those selected from the group consisting of benzyl alcohol, sorbic acid, p-hydroxybenzoic acid, mididylurea, and combinations thereof. One such preservative is a combination of about 0.5% to 2.0% benzyl alcohol and 0.05-0.5% sorbic acid.

The composition may include antioxidants and chelating agents to inhibit degradation of the compounds. For certain compounds, the antioxidants are BHT, BHA, alpha-tocopherol, and ascorbic acid in an exemplary range of about 0.01% to 0.3% by weight, or BHT in the range of 0.03% by weight, based on the total weight of the composition. % to 0.1%. The chelating agent may be present in an amount of 0.01% to 0.5% by weight, based on the total weight of the composition. Exemplary chelating agents include ethylenediaminetetraacetic acid salts (such as ethylenediaminetetraacetic acid salts) in the range of about 0.01% to 0.20% by weight, or in the range of 0.02% to 0.10% by weight, based on the total weight of the composition. disodium acetate) and citric acid. Chelating agents can be used to chelate metal ions in the composition, which can be detrimental to the shelf life of the formulation. For some compounds, although BHT and disodium edetate are exemplary antioxidants and chelating agents, respectively, other suitable and equivalent antioxidants and chelating agents may be substituted as known to those skilled in the art.

Liquid suspensions may be prepared using conventional methods to suspend the active ingredient in an aqueous or oily vehicle. Aqueous vehicles include, for example, water and isotonic saline. oily vehicle These include, for example, almond oil, oily esters, ethanol, vegetable oils such as arachis oil, olive oil, sesame oil or coconut oil, fractionated vegetable oils and mineral oils such as liquid paraffin. Liquid suspensions may further comprise one or more additional ingredients including, but not limited to, suspending agents, dispersing or wetting agents, emulsifying agents, demulcents, preservatives, buffers, salts, flavoring agents, coloring agents and sweetening agents . The oily suspensions may further comprise a thickening agent. Known suspending agents include, but are not limited to, sorbitol syrup, hydrogenated edible fats, sodium alginate, polyvinylpyrrolidone, gum tragacanth, gum arabic, and cellulose derivatives such as sodium carboxymethylcellulose, formazan, Base cellulose, hypromellose. Known dispersants or wetting agents include, but are not limited to, naturally occurring phospholipids such as lecithin, alkylene oxides with fatty acids, with long chain aliphatic alcohols, with partial esters derived from fatty acids and hexitols or with fatty acids and hexitols. Partial esters of sugar-alcohol anhydrides (e.g., polyoxyethylene stearate, heptadecanylethyleneoxycetyl alcohol, polyoxyethylene sorbitan monooleate and polyoxyethylene sorbitan monooleate, respectively ) condensation products. Known emulsifiers include, but are not limited to, lecithin, acacia, and ionic or nonionic surfactants. Known preservatives include, but are not limited to, methyl, ethyl or n-propyl paraben, ascorbic acid and sorbic acid. Known sweeteners include, for example, glycerin, propylene glycol, sorbitol, sucrose and saccharin.

Liquid solutions of active ingredients in aqueous or oily solvents can be prepared in substantially the same manner as liquid suspensions, the main difference being that the active ingredients are dissolved rather than suspended in the solvent. As used herein, an "oily" liquid is a liquid that includes carbon-containing liquid molecules and exhibits less polarity than water. Liquid solutions of the pharmaceutical compositions of the present disclosure may contain each of the components described for liquid suspensions, it being understood that suspending agents will not necessarily aid in dissolving the active ingredients in the solvent. Aqueous solvents include, for example, water and isotonic saline. Oily solvents include, for example, almond oil, oily esters, ethanol, vegetable oils such as arachis oil, olive oil, sesame oil or coconut oil, fractionated vegetable oils and mineral oils such as liquid paraffin.

Powdered and granular formulations of the pharmaceutical agents of the present disclosure can be prepared using known methods. Such formulations can be administered directly to a subject, eg, for forming tablets, filling capsules, or by adding an aqueous or oily vehicle thereto for the preparation of aqueous or oily suspensions or solutions. Each of these formulations may further include one or more of dispersing or wetting agents, suspending agents, ionic and nonionic surfactants and preservatives. These The formulations may also include additional excipients, such as fillers and sweetening, flavoring or coloring agents.

The pharmaceutical compositions of the present disclosure may also be prepared, packaged, or sold in the form of oil-in-water emulsions or water-in-oil emulsions. The oily phase may be a vegetable oil such as olive oil or peanut oil, a mineral oil such as liquid paraffin, or a combination of these. Such compositions may further comprise one or more emulsifiers, such as naturally occurring gums such as acacia or tragacanth; naturally occurring phospholipids such as soy or lecithin; esters or metabolites derived from combinations of fatty acids and hexitol anhydrides; Esters, such as sorbitan monooleate, and condensation products of such partial esters with ethylene oxide, such as polyoxyethylene sorbitan monooleate. These emulsions may also contain additional ingredients including, for example, sweetening or flavoring agents.

Methods of impregnating or coating materials with chemical compositions are known in the art, and include, but are not limited to, methods of depositing or incorporating chemical compositions onto surfaces, in synthetic materials (i.e., such as using physiologically degraded materials), and methods of absorbing aqueous or oily solutions or suspensions into absorbent materials, with or without subsequent drying. Methods of mixing the components include physical milling, the use of pellets in solid and suspension formulations and mixing in transdermal patches known to those skilled in the art.

administration / administration

Dosage regimens may affect what constitutes an effective amount. Therapeutic formulations can be administered to the patient either before or after the onset of the disease or condition. Furthermore, several divided doses as well as staggered doses may be administered daily or sequentially, or the dose may be infused continuously, or may be a bolus injection. In addition, the dosage of therapeutic formulations may be proportionally increased or decreased as indicated by the exigencies of the therapeutic or prophylactic situation.

Compositions of the present disclosure may be administered to a patient, such as a mammal, such as a human, using known procedures, at dosages and for periods of time effective to treat the diseases or conditions contemplated herein. The effective amount of a therapeutic compound necessary to achieve a therapeutic effect may vary depending on factors such as the activity of the particular compound employed; the time of administration; the excretion of the compound rate; duration of treatment; other drugs, compounds or materials used in combination with the compound; state of the disease or condition, age, sex, weight, condition, general health, and past medical history of the patient being treated, as well as similar factors. Dosage regimens may be adjusted to provide the optimum therapeutic response. For example, several divided doses may be administered daily or the dose may be proportionally reduced as indicated by the exigencies of the therapeutic situation. A non-limiting example of an effective dosage range for a therapeutic compound of the present disclosure is about 0.01 mg/kg to 100 mg/kg body weight per day. Those of ordinary skill in the art will be able to investigate the relevant factors and determine an effective amount of a therapeutic compound without undue experimentation.

The compound may be administered to the animal frequently several times a day, or may be administered less frequently, such as once a day, once a week, once every two weeks, once a month, or even less frequently, such as once every few months , or even once a year or less. It is understood that the amount of compound administered daily may be administered daily, every other day, every 2 days, every 3 days, every 4 days, or every 5 days, in non-limiting examples. For example, administered every other day, a daily dose of 5 mg may be initiated on Monday, a first subsequent daily dose of 5 mg is administered on Wednesday, a second subsequent daily dose of 5 mg is administered on Friday, and so on. The frequency of dosage will be apparent to the skilled artisan and will depend on many factors such as, but not limited to, the type and severity of the disease being treated and the type and age of the animal.

Actual dosage levels of the active ingredients in the pharmaceutical compositions of the present disclosure may be varied in order to obtain an amount of the active ingredient effective to achieve the desired therapeutic response for a particular patient, composition, and mode of administration, without being toxic to the patient.

A physician of ordinary skill in the art, such as a physician or veterinarian, can readily determine and prescribe the required effective amount of the pharmaceutical composition. For example, a physician or veterinarian could start dosages of the compounds of the disclosure employed in pharmaceutical compositions at levels lower than that required in order to achieve the desired therapeutic effect and gradually increase the dosage until the desired effect is achieved.

In particular embodiments, it is especially advantageous to formulate compounds in dosage unit form for ease of administration and uniformity of dosage. Dosage unit form as used herein refers to physically discrete units suited as unitary dosages for the patients to be treated; each unit containing a predetermined quantity of therapeutic compound calculated to be in association with the required pharmaceutical vehicle to produce the desired therapeutic effect. Dosage unit forms of the present disclosure are dictated by and directly dependent on (a) the unique characteristics of the therapeutic compound and the particular therapeutic effect to be achieved, and (b) the formulation/formulation of such treatment for the disease or condition in the patient. Inherent limitations in the field of compounds.

In certain embodiments, a composition of the present disclosure is administered to a patient in a dose ranging from 1-5 or more times per day. In other embodiments, a composition of the present disclosure is administered to a patient in a dosage range including, but not limited to, once a day, once every two days, once every three days to once a week, and once every two weeks. It will be apparent to those skilled in the art that the frequency of administration of the various combination compositions of the present disclosure will vary from subject to subject, depending on a number of factors including, but not limited to, age, disease or condition to be treated, sex , overall health and other factors. Accordingly, the present disclosure should not be construed as being limited to any particular dosage regimen, and the precise dosage and composition to be administered to any patient will be determined by the attending physician taking into account all other factors of the patient.

Compounds of the disclosure for administration may range from about 1 μg to about 7,500 mg, about 20 μg to about 7,000 mg, about 40 μg to about 6,500 mg, about 80 μg to about 6,000 mg, about 100 μg to about 5,500 mg, About 200 μg to about 5,000 mg, about 400 μg to about 4,000 mg, about 800 μg to about 3,000 mg, about 1 mg to about 2,500 mg, about 2 mg to about 2,000 mg, about 5 mg to about 1,000 mg, about 10 mg to about 750 mg, about 20 mg to about 600 mg, about 30 mg to about 500 mg, about 40 mg to about 400 mg, about 50 mg to about 300 mg, about 60 mg to about 250 mg, about 70 mg to about 200 mg, about 80 mg to about 150 mg and any whole increments and fractions therebetween increment.

In some embodiments, the dose of a compound of the disclosure is between about 0.5 μg and about 5,000 mg. In some embodiments, the dose of a compound of the disclosure used in the compositions described herein is less than about 5,000 mg, or less than about 4,000 mg, or less than about 3,000 mg, or less than about 2,000 mg, or less than about 1,000 mg, Or less than about 800 mg, or less than about 600 mg, or less than about 500 mg, or less than about 200 mg, or less than about 50 mg. Similarly, in some embodiments, a second compound as described herein The dosage is less than about 1,000 mg, or less than about 800 mg, or less than about 600 mg, or less than about 500 mg, or less than about 400 mg, or less than about 300 mg, or less than about 200 mg, or less than about 100 mg, or less than about 50 mg, or less than about 40 mg, or less than about 30 mg, or less than about 25 mg, or less than about 20 mg, or less than about 15 mg, or less than about 10 mg, or less than about 5 mg, or less than about 2 mg, or less than about 1 mg, or less than about 0.5 mg, and Any full and partial increments.

In certain embodiments, the present disclosure relates to packaged pharmaceutical compositions comprising a container containing a therapeutically effective amount of a compound of the present disclosure, alone or in combination with a second drug; and using the compound to treat, prevent, or alleviate A description of one or more symptoms of a patient's disease or condition.

The term "container" includes any receptacle for containing a pharmaceutical composition or for managing stability or water absorption. For example, in certain embodiments, the container is a package containing a pharmaceutical composition, such as a liquid (solution and suspension), semi-solid, lyophilized solid, solution and powder or lyophilized formulation present in a dual compartment. In other embodiments, the container is not a package containing a pharmaceutical composition, ie, the container is a receptacle, such as a box or vial containing a packaged or unpackaged pharmaceutical composition and instructions for use of the pharmaceutical composition. Additionally, packaging techniques are well known in the art. It will be appreciated that instructions for use of the pharmaceutical composition may be included on the packaging containing the pharmaceutical composition, and thus the instructions form an increased functional relationship with the packaged product. It should be understood, however, that the instructions may contain information regarding the ability of the compound to perform its intended function, such as treating, preventing or alleviating a disease or condition in a patient.

apply

Routes of administration for any composition of the present disclosure include inhalation, oral, nasal, rectal, parenteral, sublingual, transdermal, transmucosal (e.g., sublingual, lingual, (trans)buccal, (trans)urethral, vaginal (e.g., vaginal and perivaginal), nasal (intra) and ((trans)rectal), intravesical, intrapulmonary, intraduodenal, intragastric, intrathecal, epidural, intrapleural, intraperitoneal, subcutaneous, intramuscular Intradermal, intradermal, intraarterial, intravenous, intrabronchial, inhalation and topical administration.

Suitable compositions and dosage forms include, for example, tablets, capsules, caplets, pills, softgels, lozenges, emulsions, dispersions, suspensions, solutions, syrups, granules, beads, transdermal patches, gels elixirs, powders, pellets, magmas, lozenges, creams, pastes, plasters, lotions, tablets (discs), suppositories, liquid sprays for nasal or oral administration, for Dry powder or nebulized formulations for inhalation, compositions and formulations for intravesical administration, and the like. It should be understood that formulations and compositions useful in the present disclosure are not limited to the specific formulations and compositions described herein.

oral administration

For oral administration, especially suitable are tablets, lozenges, liquids, drops, capsules, caplets and soft capsules. Other formulations suitable for oral administration include, but are not limited to, powder or granule formulations, aqueous or oily suspensions, aqueous or oily solutions, pastes, gels, toothpastes, mouthwashes, coatings, mouth rinses or emulsions . Compositions intended for oral use may be prepared according to any method known in the art, and such compositions may contain an inert, non-toxic, generally recognized as safe (GRAS) medicinal product selected from the group suitable for the manufacture of tablets. One or more agents of the above excipients. Such excipients include, for example, inert diluents such as lactose; granulating and disintegrating agents such as corn starch; binders such as starches; and lubricants such as magnesium stearate.

Tablets may be uncoated, or may be coated using known methods to effect delayed disintegration in the gastrointestinal tract of a subject so as to provide sustained release and absorption of the active ingredient. Tablets may be coated, for example, with a material such as glyceryl monostearate or glyceryl distearate. By way of further example, tablets may be coated to form osmotic controlled release tablets using the methods described in US Pat. Nos. 4,256,108; 4,160,452; and 4,265,874. Tablets may further contain sweetening agents, flavoring agents, coloring agents, preservatives or some combination of these to provide a pharmaceutically elegant and palatable preparation. Hard capsules containing the active ingredient can be prepared using physiologically degradable compositions such as gelatin. Capsules contain the active ingredient and may further contain additional ingredients including, for example, inert solid diluents such as calcium carbonate, calcium phosphate or kaolin.

Hard capsules containing the active ingredient can be prepared using physiologically degradable compositions such as gelatin. Such hard capsules contain the active ingredient and may further contain additional ingredients including, for example, inert solid diluents such as calcium carbonate, calcium phosphate or kaolin.

Soft capsules comprising the active ingredient can be prepared using a physiologically degradable composition such as gelatin from animal collagen or hypromellose (a modified form of cellulose), and using gelatin, water and a plasticizer such as sorbitol Manufactured with an optional mixture of sugar alcohols or glycerin. Such soft capsules contain the active ingredient which may be mixed with water or an oily medium such as peanut oil, liquid paraffin or olive oil.

For oral administration, the compounds of the present disclosure may be in the form of tablets or capsules prepared by conventional methods with pharmaceutically acceptable excipients such as binders; fillers; lubricants; disintegrants; or wetting agents. If desired, suitable methods and coating materials such as those available from Colorcon, West Point, Pa. (e.g., OPADRY® Type OY, OYC, Organic Enteric OY-P, Aqueous Enteric OY- Form A, OY-PM and OPADRY® White, 32K18400) coated tablets with the OPADRY® Film Coating System. It should be understood that similar types of film coatings or polymerization products from other companies may be used.

A tablet comprising the active ingredient may be prepared, for example, by compressing or molding the active ingredient, optionally with one or more additional ingredients. Compressed tablets may be prepared by compressing in a suitable machine the active ingredient in a free-flowing form such as a powder or granule formulation, optionally mixed with one or more binder, lubricant, excipient, surface active and dispersing agents. Molded tablets can be made by molding, in a suitable device, a mixture of the active ingredient, a pharmaceutically acceptable carrier and at least sufficient liquid to wet the mixture. Pharmaceutically acceptable excipients used in the manufacture of tablets include, but are not limited to, inert diluents, granulating and disintegrating agents, binders and lubricants. Known dispersants include, but are not limited to, potato starch and sodium carboxymethyl starch. Known surfactants include, but are not limited to, sodium lauryl sulfate. Known diluents include, but are not limited to, calcium carbonate, sodium carbonate, lactose, microcrystalline cellulose, calcium phosphate, calcium hydrogen phosphate, and sodium phosphate. Known granulating and disintegrating agents include, but are not limited to, corn starch and alginic acid. Known binders include, but are not limited to, gelatin, gum arabic, pregelatinized corn starch, polyvinylpyrrole pyridone and hydroxypropyl methylcellulose. Known lubricants include, but are not limited to, magnesium stearate, stearic acid, silicon dioxide and talc.

Granulation techniques are well known in the pharmaceutical field and are used to modify active ingredients from starting powders or other granular materials. Powders are usually mixed with a binder material into larger permanent free-flowing agglomerates or granules known as "granulation". For example, the general feature of "wet" granulation using solvents is that a powder is mixed with a binder material and wetted under certain conditions with water or an organic solvent to form a wet granular material from which the solvent must then be evaporated .

Melt granulation generally involves the use of materials that are solid or semi-solid at room temperature (i.e., have a relatively low softening or melting point range) to facilitate the preparation of powders or other materials substantially without the addition of water or other liquid solvents. grain. When heated to a temperature in the melting point range, the low melting point solid liquefies to act as a binder or granulation medium. The liquefied solid spreads itself on the surface of the powdered material it comes into contact with and upon cooling forms a solid granular mass in which the starting substances are bound together. The resulting melt granulation can then be fed to a tablet press or packaged to make oral dosage forms. Melt granulation improves the dissolution rate and bioavailability of active substances (ie, drugs) by forming solid dispersions or solid solutions.

US Patent No. 5,169,645 discloses directly compressible waxy particles with improved flow characteristics. Pellets are obtained when wax is mixed in the melt with certain flow-improving additives, then the mixture is cooled and pelletized. In certain embodiments, only the wax itself is melted in the molten composition of the wax(s) and additive(s), and in other cases, the wax(s) and additive(s) Both will melt.

The present disclosure also includes a multilayer tablet comprising a layer providing for delayed release of one or more compounds useful in the methods of the present disclosure and providing for immediate release of one or more compounds useful in the methods of the present disclosure. Additional layers of compound. Using wax/pH sensitive polymer mixtures, it is possible to obtain gastro-insoluble compositions in which the active ingredient is entrapped ensuring its delayed release.

Liquid formulations for oral administration may be in the form of solutions, syrups or suspensions. Liquid formulations may be prepared in a conventional manner with pharmaceutically acceptable additives such as suspending agents (for example, sorbitol syrup, methylcellulose, or hydrogenated edible fats); emulsifying agents; (eg, lecithin or acacia); a non-aqueous vehicle (eg, almond oil, oily esters, or ethanol); and a preservative (eg, methyl or propyl paraben or sorbic acid). Liquid formulations of the pharmaceutical compositions of the present disclosure suitable for oral administration can be prepared, packaged, and sold in liquid form or as a dry product intended for reconstitution with water or another suitable vehicle before use.

parenteral administration

As used herein, "parenteral administration" of a pharmaceutical composition includes any route of administration characterized by physical disruption of a subject's tissue and administration of the pharmaceutical composition through the disruption in the tissue. Parenteral administration thus includes, but is not limited to, administering the pharmaceutical composition by injection of the composition, administering the composition through a surgical incision, administering the composition through a non-surgical wound that penetrates tissue, and the like. In particular, parenteral administration is contemplated including, but not limited to, subcutaneous, intravenous, intraperitoneal, intramuscular, intrasternal injection and renal dialysis infusion techniques.

Formulations of pharmaceutical compositions suitable for parenteral administration include the active ingredient in combination with a pharmaceutically acceptable carrier, such as sterile water or sterile isotonic saline. Such formulations can be prepared, packaged or sold in a form suitable for bolus administration or continuous administration. Injectable formulations can be prepared, packaged, or sold in unit dosage form, eg, in ampoules or in multi-dose containers, with a preservative. Injectable formulations can also be prepared, packaged, or sold in devices such as patient-controlled analgesia (PCA) devices. Formulations for parenteral administration include, but are not limited to, suspensions, solutions, emulsions in oily or aqueous vehicles, ointments and implantable sustained-release or biodegradable formulations. Such formulations may further comprise one or more additional ingredients including, but not limited to, suspending, stabilizing or dispersing agents. In one embodiment of the formulation for parenteral administration, the active ingredient is provided in dry (i.e., powder or granule) form for reconstitution with a suitable vehicle (e.g., sterile pyrogen-free water) prior to parenteral administration Reconstituted composition.

The pharmaceutical compositions can be prepared, packaged or sold in the form of sterile injectable aqueous or oily suspensions or solutions. This suspension or solution may be formulated according to known techniques and may contain, in addition to the active ingredient, further ingredients such as dispersing, wetting or suspending agents herein described. Nontoxic parenterally acceptable diluents or solvents such as Such sterile injectable formulations are prepared, for example, with water or 1,3-butanediol. Other acceptable diluents and solvents include, but are not limited to, Ringer's solution, isotonic sodium chloride solution, and fixed oils such as synthetic mono- or diglycerides. Other parenterally administrable formulations that are useful include those comprising the active ingredient in microcrystalline form in recombinant human albumin, fluidized gelatin, liposomal formulations or as a component of biodegradable polymer systems. Compositions for sustained release or implantation may include pharmaceutically acceptable polymers or hydrophobic materials such as emulsions, ion exchange resins, sparingly soluble polymers or sparingly soluble salts.

topical application

An obstacle to topical application of pharmaceutical preparations is the stratum corneum of the epidermis. The stratum corneum is a highly resistant layer composed of proteins, cholesterol, sphingolipids, free fatty acids, and various other lipids, and includes keratinocytes and living cells. One of the factors that limits the penetration rate (flux) of a compound across the stratum corneum is the amount of active that can be loaded or applied to the skin surface. The greater the amount of active applied per unit area of skin, the greater the concentration gradient between the surface of the skin and the underlying layers of the skin, and thus the greater the diffusion of the active across the skin. Thus, formulations containing higher concentrations of actives are more likely to result in more actives permeating through the skin at a more consistent rate than other formulations of lower concentrations, all other things being equal.

Formulations suitable for topical administration include, but are not limited to, liquid or semi-liquid preparations such as liniments, lotions, oil-in-water or water-in-oil emulsions such as creams, salves or pastes, and solutions or suspensions. Topically administrable formulations may, for example, comprise from about 1% to about 10% (w/w) active ingredient, although the concentration of the active ingredient may be the same as the solubility limit of the active ingredient in a solvent. Formulations for topical administration may further comprise one or more additional ingredients as described herein.

Penetration enhancers may be used. These materials increase the permeability of drugs through the skin. Typical accelerators in the art include ethanol, glyceryl monolaurate, PGML (polyethylene glycol monolaurate), dimethylsulfoxide, and the like. Other accelerators include oleic acid, oleyl alcohol, ethoxylated glycol, laurocapram, alkanecarboxylic acids, dimethylsulfoxide, polar lipids, or N-methyl-2-pyrrolidone.

One acceptable vehicle for topical delivery of some compositions of the present disclosure may comprise liposomes. The composition of liposomes and their use are known in the art (ie, US Patent No. 6,323,219).

In alternative embodiments, topically active pharmaceutical compositions may optionally be mixed with other ingredients such as adjuvants, antioxidants, chelating agents, surfactants, foaming agents, wetting agents, emulsifiers, viscosity builders, buffers, Agents, preservatives and other combinations. In other embodiments, a penetration or penetration enhancer is included in the composition and is effective to improve the penetration of the active ingredient into the skin and across the stratum corneum relative to a composition lacking the penetration enhancer. Various penetration enhancers, including oleic acid, oleyl alcohol, ethoxylated glycol, laurocapram, alkane carboxylic acids, dimethylsulfoxide, polar lipids or N-methyl-2-pyrrolidone are known in the art known to the skilled person. In another aspect, the composition may further comprise a hydrotrope, which acts to increase the disorder of the stratum corneum structure and thus allows increased transport across the stratum corneum. Various hydrotropes such as isopropanol, propylene glycol or sodium xylene sulfonate are known to those skilled in the art.

Topically active pharmaceutical compositions should be administered in amounts effective to effect the desired change. An "effective amount" as used herein refers to an amount sufficient to cover the area of the skin surface in need of modification. The active compound should be present in an amount of from about 0.0001% to about 15% by weight volume of the composition. For example, it should be present in an amount of about 0.0005% to about 5% of the composition; for example, it should be present in an amount of about 0.001% to about 1% of the composition. Such compounds may be of synthetic or natural origin.

buccal administration

The pharmaceutical compositions of the present disclosure may be prepared, packaged, or sold in a formulation suitable for buccal administration. Such formulations may, for example, be in the form of tablets or lozenges prepared using conventional methods, and may contain, for example, 0.1 to 20% (w/w) active ingredient, the balance comprising orally dissolvable or degradable constituents. , and optionally one or more additional ingredients described herein. Alternatively, formulations suitable for buccal administration may include powdered or aerosolized or atomized solutions or suspensions containing the active ingredient. When dispersed, such powdered, aerosolized or nebulized formulations may have to an average particle or droplet size in the range of about 200 nanometers, and may further comprise one or more additional ingredients as described herein. The examples of formulations described herein are not exhaustive, and it is to be understood that this disclosure includes additional modifications of these and other formulations not described herein but known to those skilled in the art.

rectal administration

The pharmaceutical compositions of the present disclosure may be prepared, packaged, or sold in formulations suitable for rectal administration. Such compositions may be in the form of, for example, suppositories, retention enema formulations and solutions for rectal or colonic lavage.

Suppository formulations can be prepared by mixing the active ingredient with a non-irritating pharmaceutically acceptable excipient which is solid at normal room temperature (ie, about 20°C) and which is stable in the subject's It is liquid at rectal temperature (ie, about 37°C in a healthy human). Suitable pharmaceutically acceptable excipients include, but are not limited to, cocoa butter, polyethylene glycols and various glycerides. Suppository formulations may further contain various additional ingredients including, but not limited to, antioxidants and preservatives.

Retention enema formulations or solutions for rectal or colonic lavage can be prepared by mixing the active ingredient with a pharmaceutically acceptable liquid carrier. The enema formulation can be administered using a delivery device adapted to the rectal anatomy of the subject, and can be packaged in the delivery device, as is well known in the art. Enema formulations may further contain various additional ingredients including, but not limited to, antioxidants and preservatives.

Additional forms of administration

Additional dosage forms of the present disclosure include dosage forms as described in US Pat. Additional dosage forms of the present disclosure also include dosage forms as described in US Patent Application Nos. 20030147952, 20030104062, 20030104053, 20030044466, 20030039688, and 20020051820. Additional dosage forms of the present disclosure also include those described in PCT Application Nos. WO 03/35041, WO 03/35040, WO 03/35029, WO 03/35177, WO 03/35039, WO 02/96404, WO 02/32416, WO 01/97783, WO 01/56544, WO 01/32217, WO 98/55107, WO 98/11879, WO Dosage forms described in WO 97/47285, WO 93/18755 and WO 90/11757.

Controlled release formulations and drug delivery systems:

In certain embodiments, compositions and/or formulations of the present disclosure may be, but are not limited to, short-term, fast-compensating, and controlled, eg, sustained-release, delayed-release, and pulsed-release formulations.

The term sustained release in its conventional sense refers to a pharmaceutical formulation that gradually releases a drug over an extended period of time, resulting in, though not necessarily, a substantially constant blood level of the drug over an extended period of time. This period of time can be as long as a month or more, and should be longer than the same amount administered as a bolus injection.

For sustained release, the compounds can be formulated with suitable polymers or hydrophobic materials which impart sustained release characteristics to the compounds. Thus, compounds for use in the methods of the present disclosure may be administered in particulate form by, for example, injection, or in the form of wafers or discs by implantation.

In certain embodiments of the present disclosure, a compound useful in the present disclosure is administered to a subject using a sustained release formulation, alone or in combination with another agent.

The term delayed release herein refers in its conventional sense to pharmaceutical formulations that provide initial release of the drug after a certain delay after drug administration, and may, though not necessarily, include from about 10 minutes up to about 12 hours.

The term pulsed release refers herein in its conventional sense to pharmaceutical formulations that provide drug release in such a way that following drug administration results in a pulsed plasma distribution.

The term immediate release in its conventional sense refers to pharmaceutical formulations that provide release of the drug immediately after administration of the drug.

As used herein, short-term refers to any period of time after drug administration, up to and including about 8 hours, about 7 hours, about 6 hours, about 5 hours after drug administration hours, about 4 hours, about 3 hours, about 2 hours, about 1 hour, about 40 minutes, about 20 minutes, or about 10 minutes and any or all whole or partial increments thereof.

As used herein, rapid compensation refers to any period of time after drug administration, up to and including about 8 hours, about 7 hours, about 6 hours, about 5 hours, about 4 hours, about 3 hours, about 2 hours, about 1 hour, about 40 minutes, about 20 minutes, or about 10 minutes, and any full and partial increments thereof.

Those skilled in the art will recognize, or be able to ascertain, using no more than routine experimentation, many equivalents to the specific procedures, embodiments, claims, and examples described herein. Such equivalents are considered to be within the scope of this disclosure and are covered by the appended claims. For example, it is understood that art-recognized alternatives are employed and only routine experimentation is used, including but not limited to reaction times, reaction size/volume, and experimental reagents such as solvents, catalysts, pressure, atmospheric conditions such as nitrogen atmosphere , and the improvement of the reaction conditions of the reducing agent/oxidizing agent are all within the scope of the present application.

It should be understood that wherever values and ranges are provided herein, the description in range format is merely for convenience and brevity and should not be construed as an inflexible limitation on the scope of the disclosure. Accordingly, all values and ranges encompassed by these values and ranges are intended to be encompassed within the scope of this disclosure. In addition, this application also contemplates all values falling within these ranges, as well as the upper or lower limits of that range of values. The description of a range should be considered to have expressly disclosed all possible subranges as well as individual values within that range and, where appropriate, sub-integers of values within that range. For example, a description of a range from 1 to 6 should be considered to have expressly disclosed the range from 1 to 3, from 1 to 4, from 1 to 5, from 2 to 4, from 2 to 6, from 3 to 6, etc. range, and individual values within that range, such as 1, 2, 2.7, 3, 4, 5, 5.3, and 6. This applies regardless of the breadth of the range.

The following examples further illustrate aspects of the present disclosure. In no way, however, are limitations on the teaching or disclosure of the disclosure set forth herein.

Example

The present disclosure is now described with reference to the following examples. These examples are provided for the purpose of illustration only, and the present disclosure is not limited to these examples, but covers all modifications apparent as a result of the teaching provided herein.

As used herein, the terms "major diastereomer" and "minor diastereomer" refer to the relative amounts of diastereomers obtained under specified reaction conditions, wherein "major diastereoisomer" "enantiomer" is obtained in higher amounts than the "minor diastereomer". In certain embodiments, the major diastereomer retains the stereochemistry of the starting material used to prepare the compound, while the minor diastereomer is at least partially epimerized And caused.

Example 1: N -((2 S )-1-((1-(4-chlorothiazol-2-yl)-1-oxo-3-(( S )-2-oxopyrrolidine-3 -yl)propan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy- 1H -indole-2-carboxamide (compound 1 and 2)

Step (1): (4-Methoxy-1H-indole-2-carbonyl)-L-leucine methyl ester

To a stirred suspension of 4-methoxy-lH-indole-2-carboxylic acid (2 g, 10.47 mmol) in DMF (20 mL) was added HATU (5.96 g, 15.70 mmol) at 0 °C. After 20 minutes, a solution of L-leucine methyl ester hydrochloride (1.89 g, 10.47 mmol) in DMF (1 mL) was added followed by N,N -diisopropylethylamine (5.6 mL, 31.43 mmol ). The reaction mixture was stirred at 0 °C for 3 hours. The reaction was diluted with saturated aqueous ammonium chloride (10 mL) and the layers were separated. The aqueous phase was extracted with _CH2Cl2 (2 _x 10 mL). The combined organic phases were washed with saturated aqueous sodium bicarbonate (10 mL), _H2O (10 mL), brine solution (10 mL), dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. The crude residue was purified by normal phase _SiO2 chromatography (0 to 100% EtOAc/heptane) to afford (4-methoxy-1H-indole-2-carbonyl)-L-leucine methyl ester (1.6 g, 48% yield, observed m/z: 319 [M+H] ⁺ ).

Step (2): (4-methoxy-1H-indole-2-carbonyl)-L-leucine

To a stirred solution of (4-methoxy-1H-indole-2-carbonyl)-L-leucine methyl ester (3.00 g, 9.42 mmol) in THF (5 mL) was added lithium hydroxide (1M in water, 38 mL , 37.6 mmol). The reaction was stirred at room temperature for 1 hour. The mixture was acidified to pH 5 with aqueous hydrochloric acid (1 N) and extracted with EtOAc (3 x 10 mL). The combined organic phases were washed with _H2O (10 mL), brine solution (10 mL), dried over anhydrous sodium sulfate, filtered and concentrated in vacuo to afford (4-methoxy-1H-indole-2-carbonyl ) -L -leucine, which was used in the next step without further purification (2.5 g, observed m/z: 305 [M+H] ⁺ ).

Step (3): (S)-2-((tert-butoxycarbonyl)amino)-3-((S)-2-oxopyrrolidin-3-yl)propanoic acid

To (2S)-2-(tert-butoxycarbonylamino)-3-[(3S)-2-oxopyrrolidin-3-yl]propionic acid methyl ester (10g, 34.9mmol) at 0°C The mixture in MeOH (20 mL) was added dropwise with NaOH (4N in water, pre-cooled to 0 °C, 35 mL, 139.7 mmol). The internal reaction temperature was kept below 0°C during the addition. The mixture was stirred at 0°C for 1 hour and then acidified to pH 7 with concentrated HCl while keeping the internal temperature below 10°C. The organic solvent was removed under reduced pressure. The mixture was acidified to pH 4 with concentrated HCl and extracted with EtOAc (5 x 100 mL). The combined organic phases were washed with brine solution (100 mL), dried over anhydrous sodium sulfate, filtered and concentrated in vacuo to afford ( 2S )-2-(tert-butoxycarbonylamino)-3-[( 3S )-2-oxopyrrolidin-3-yl]propionic acid, which was used in the next step without further purification (9.20 g, observed m/z: 273 [M+H] ⁺ ).

Step (4): ((S)-1-(methoxy(methyl)amino)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl)propane- 2-yl) tertiary butyl carbamate

To (2 S )-2-(tertiary butoxycarbonylamino)-3-[(3 S )-2-oxopyrrolidin-3-yl]propanoic acid (8.66g) in DMF at room temperature (80 mL) was added EDC hydrochloride (7.32 g, 38.2 mmol), HOBt monohydrate (5.84 g, 38.2 mmol) and N -methoxymethylamine hydrochloride (4.34 g, 44.5 mmol). The reaction was cooled to 0 °C and triethylamine (11 mL, 79.5 mmol) was added dropwise over 5 min. The reaction was allowed to warm to room temperature overnight. The mixture was diluted with EtOAc (50 mL), and the resulting solid was removed by filtration through ^CELITE® . The organic phase was washed with _H2O (100 _mL ), and the aqueous phase was further extracted with EtOAc (5 x 200 mL) and _CH2Cl2 (2 x 200 mL). The combined organic phases were dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. Purification of the residue by reverse phase HPLC gave the product ((S)-1-(methoxy(methyl)amino)-1-oxo-3-((S)-2-oxopyrrolidine-3 -yl)propan-2-yl)tert-butyl carbamate (5.5 g, 55% yield, from (2S)-2-(tert-butoxycarbonylamino)-3-[(3S)- Methyl 2-oxopyrrolidin-3-yl]propionate, observed m/z: 316 [M+H] ⁺ ).

Step (S): (S)-2-Amino-N-methoxy-N-methyl-3-((S)-2-oxopyrrolidin-3-yl)propionamide hydrochloride

烷溶液，1.9mL，7.5mmol)。將反應物在室溫下攪拌24小時。在減壓下除去溶劑，得到(S)-2-胺基-N-甲氧基-N-甲基-3-((S)-2-氧代吡咯啶-3-基)丙醯胺鹽酸鹽，其無需進一步純化即可用於下一步(0.6g，m/z：觀察到216[M+H]⁺)。 To ((S)-1-(methoxy(methyl)amino)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl) A solution of tert-butyl carbamate (0.8 g, 2.5 mmol) in CH ₂ Cl ₂ (20 mL) was added to HCl (4N 1,4-di

alkane solution, 1.9mL, 7.5mmol). The reaction was stirred at room temperature for 24 hours. The solvent was removed under reduced pressure to give ( S )-2-amino- N -methoxy- N -methyl-3-(( S )-2-oxopyrrolidin-3-yl)propionamide salt Acid salt, which was used in the next step without further purification (0.6 g, m/z: 216 [M+H] ⁺ observed).

Step (6): 4-methoxy-N-((S)-1-(((S)-1-(methoxy(methyl)amino)-1-oxo-3-(( S)-2-oxopyrrolidin-3-yl)propan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-1H-indole-2-formyl amine

( 2S )-2-[(4-Methoxy-1H-indole-2-carbonyl)amino]-4-methyl-pentanoic acid (772mg) and HATU (1.74g, 4.57mmol) in DMF (5 mL) was stirred at 0°C for 10 minutes. Add ( 2S )-2-amino- N -methoxy- N -methyl-3-[(3S)-2-oxopyrrolidin-3-yl]propanamide (546mg, 2.54mmol) in A solution in DMF (0.5 mL), followed by the addition of N,N -diisopropylethylamine (1.4 mL, 7.61 mmol). The reaction was stirred at 0 °C for 1 hour and allowed to warm to room temperature overnight. The solvent was removed under reduced pressure and the residue was purified by normal phase _SiO2 chromatography (0 to 5% MeOH/ _{CH2Cl2 )} to afford 4-methoxy- N -(( S )-1-(( ( S )-1-(methoxy(methyl)amino)-1-oxo-3-(( S )-2-oxopyrrolidin-3-yl)propan-2-yl)amino )-4-methyl-1-oxopentan-2-yl)-1H-indole-2-carboxamide (1.12 g, 88% yield, observed m/z: 502 [M+H] ⁺ ).

Step (7): N-((2S)-1-((1-(4-chlorothiazol-2-yl)-1-oxo-3-((S)-2-oxopyrrolidine-3 -yl)propane-2-yl)amino)-4-methyl-1-oxopentane-2-yl)-4-methoxy-1H-indole-2-formamide

4-Methoxy- N -[(1 S )-1-[[(1 S )-2-[methoxy (methyl)amino]-2-oxo-1-[[(3 S )-2-oxopyrrolidin-3-yl]methyl]ethyl]carbamoyl]-3-methyl-butyl]-1H-indole-2-carboxamide (60mg, 0.12mmol ) and 2-bromo-4-chloro-thiazole (106 mg, 0.54 mmol) in THF (5 mL) was cooled to -78 °C. To the reaction was added n -BuLi (1.6N in hexanes, 0.34 mL, 0.54 mmol) dropwise, and the mixture was stirred at -78°C for 30 minutes and then at room temperature for 3 hours. Additional 2-bromo-4-chloro-thiazole (30 mg, 0.152 mmol) was added at -78 °C, followed by n -BuLi (1.6M in hexane, 0.1 mL, 0.16 mmol). The mixture was warmed to room temperature and stirred for 1 hour. The reaction was quenched by the addition of saturated aqueous ammonium chloride (5 mL), extracted with EtOAc (3 x 10 mL), dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. The residue was purified by reverse phase HPLC to give the crude product as a yellow foam. The residue was further purified by normal phase _SiO2 chromatography (0 to ₅ % MeOH/ _CH2Cl2 ) to provide each diastereoisomer.

Minor diastereomer (faster eluting diastereomer) (4.3 mg, 6% yield): Observed m/z: 560 [M+H] ⁺ ; ¹ H NMR (400 MHz , CDCl ₃ ): δ 10.12(s, 1H), 8.65(d, J=6.1Hz, 1H), 7.12(s, 1H), 7.02(d, J=8.7Hz, 1H), 6.95-6.90(m, 2H), 6.80(s, 1H), 6.75(d, J=8.3Hz, 1H), 6.34(d, J=7.8Hz, 1H), 5.40(ddd, J=11.5, 6.1, 3.1Hz, 1H), 4.87(td, J=8.6, 5.2Hz, 1H), 3.79(s, 3H), 3.15-3.00(m, 2H), 2.54-2.30(m, 2H), 2.24(dd, J=13.1, 7.1Hz, 1H), 2.05(ddd, J=13.8, 11.5, 5.3Hz, 1H), 2.01(ddd, J=13.9, 8.4, 3.4Hz, 1H), 1.83-1.53(m, 3H), 0.86(dd,J= 6.1, 3.4Hz, 6H).

Major diastereomer (slower eluting diastereomer) : (9.6 mg, 14% yield): Observed m/z: 560 [M+H] ⁺ ; ¹ H NMR (400 MHz , CDCl ₃ ): δ 10.26(s, 1H), 8.78(d, J=6.1Hz, 1H), 7.43(s, 1H), 7.29(d, J=8.7Hz, 1H), 7.18-7.05(m, 2H), 7.02(s, 1H), 6.95(d, J=8.3Hz, 1H), 6.44(d, J=7.8Hz, 1H), 5.50(ddd, J=11.5, 6.1, 3.1Hz, 1H), 4.97(td, J=8.6, 5.2Hz, 1H), 3.89(s, 3H), 3.25-3.08(m, 2H), 2.64-2.40(m, 2H), 2.34(dd, J=13.1, 7.1Hz, 1H), 2.15(ddd, J=13.8, 11.5, 5.3Hz, 1H), 2.01(ddd, J=13.9, 8.4, 3.4Hz, 1H), 1.93-1.63(m, 3H), 0.96(dd,J= 6.1, 3.4Hz, 6H).

Example 2: N -((2 S )-1-((1-(4-chlorothiazol-2-yl)-1-oxo-3-(( S )-2-oxopyrrolidine-3 -yl)propan-2-yl)amino)-3-cyclohexyl-1-oxopropan-2-yl)-4-methoxy- 1H -indole-2-carboxamide (compound 3 and 4)

With appropriate Weinreb amide and appropriately substituted thiazoles with respect to N -(( 2S )-1-((1-(4-chlorothiazol-2-yl)-1-oxo-3-(( S )-2-oxopyrrolidin-3-yl)propan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy- 1H -ind N -(( 2S )-1-((1-(4-chlorothiazol-2-yl)-1-oxo-3-(( S )-2-oxopyrrolidin-3-yl)propan-2-yl)amino)-3-cyclohexyl-1-oxopropan-2-yl)-4-methoxy- 1H -indole -2-Formamide.

Minor diastereomer : Observed m/z: 600[M+H] ⁺ ; ¹ H NMR (400MHz, CDCl ₃ ): δ 9.76(s, 1H), 8.88(d, J=6.0Hz, 1H), 7.47(dd, J=2.5, 0.4Hz, 1H), 7.24-7.17(m, 1H), 7.16-7.11(m, 1H), 7.04(d, J=8.2Hz, 1H), 6.66(d , J=8.2Hz, 1H), 6.51(d, J=7.8Hz, 1H), 5.96(s, 1H), 5.61(q, J=5.5Hz, 1H), 4.83(td, J=9.0, 4.6Hz , 1H), 4.25-4.2(m,1H), 3.95(s,3H), 3.24-3.02(m,2H), 2.49(s,2H), 2.32-2.06(m,2H), 1.89-1.62(m ,4H), 1.45(d, J=9.5Hz, 3H), 1.31-1.11(m,4H), 1.11-0.85(m,2H).

Major diastereomer : Observed m/z: 600[M+H] ⁺ ; ¹ H NMR (400MHz, CDCl ₃ ): δ 9.76(s, 1H), 8.88(d, J=6.0Hz, 1H ), 7.47(dd, J=2.5, 0.4Hz, 1H), 7.24-7.17(m, 1H), 7.16-7.11(m, 1H), 7.04(d, J=8.2Hz, 1H), 6.66(d, J=8.2Hz, 1H), 6.51(d, J=7.8Hz, 1H), 5.96(s, 1H), 5.61(q, J=5.5Hz, 1H), 4.83(td, J=9.0, 4.6Hz, 1H), 4.25-4.2(m,1H), 3.95(s,3H), 3.24-3.02(m,2H), 2.49(s,2H), 2.32-2.06(m,2H), 1.89-1.62(m, 4H), 1.45(d, J=9.5Hz, 3H), 1.31-1.11(m, 4H), 1.11-0.85(m, 2H).

Example 3: 9-Hydroxy-N-((S)-4-methyl-1-(((S)-4-(methylamino)-3,4-dioxo-1-((S)- 2-oxopyrrolidin-3-yl)butane-2-yl)amino)-1-oxopentane-2-yl)-9H-oxo-9-formamide (compound 5)

Step (1): Methyl (S)-2-amino-3-((S)-2-oxopyrrolidin-3-yl)propionate hydrochloride

烷溶液，20mL，80.1mmol)。將反應物在室溫下攪拌12小時。將混合物在減壓下濃縮，得到(S)-2-胺基-3-((S)-2-氧代吡咯啶-3-基)丙酸甲酯鹽酸鹽，其無需進一步純化即可用於下一步(3g，觀察到m/z：187[M+H]⁺)。 To (S)-2-((tertiary butoxycarbonyl)amino)-3-((S)-2-oxopyrrolidin-3-yl)propanoic acid methyl ester (5.0g, 17.4mmol) in A solution in CH ₂ Cl ₂ (20 mL) was added with HCl (4M in 1,4-di

alkane solution, 20mL, 80.1mmol). The reaction was stirred at room temperature for 12 hours. The mixture was concentrated under reduced pressure to afford methyl (S)-2-amino-3-((S)-2-oxopyrrolidin-3-yl)propanoate hydrochloride which was used without further purification In the next step (3g, observed m/z: 187 [M+H] ⁺ ).

Step (2): (S)-2-((S)-2-((tert-butoxycarbonyl)amino)-4-methylpentanamide)-3-((S)-2-oxo Methyl pyrrolidin-3-yl)propionate

To a solution of (tert-butoxycarbonyl) -L -leucine (10 g, 43.3 mmol) in CH ₂ Cl ₂ (50 mL) and DMF (50 mL) was added HATU (26.5 g , 69.3mmol), and the mixture was stirred for 20min. The crude product (S)-methyl 2-amino-3-((S)-2-oxopyrrolidin-3-yl)propanoate hydrochloride (9.7 g) was added in one portion, and the mixture was stirred at - Stir at 10 °C for 30 min. Then DIPEA (1.7 mL, 10.5 mmol) was added dropwise over 2 min, and the mixture was stirred at -10 °C for 12 h. The reaction mixture was washed with saturated aqueous ammonium chloride (3 x 100 mL), and extracted with _CH2Cl2 ( ₃₀₀ mL). The organic layer was further washed with saturated aqueous sodium bicarbonate (3 x 100 mL) and brine solution (3 x 100 mL). The combined organic extracts were dried over anhydrous sodium sulfate and concentrated under vacuum. Purification of the residue via normal phase _SiO2 chromatography (0-10% MeOH/ _CH2Cl2 ) afforded (S)-2-( ₍ S)-2-((tert-butoxycarbonyl)amino) -4-Methylpentamide)-3-((S)-2-oxopyrrolidin-3-yl)propanoic acid methyl ester (12 g, yield 80%, observed m/z: 400 [M+ H] ⁺ ).

Step (3): (S)-2-((S)-2-Amino-4-methylpentanamide)-3-((S)-2-oxopyrrolidin-3-yl)propanoic acid methyl ester

烷溶液，40mL，160mmol)。將反應混合物在室溫下攪拌12小時，並且然後在減壓下濃縮，得到(S)-2-((S)-2-胺基-4-甲基戊醯胺)-3-((S)-2-氧代吡咯啶-3-基)丙 酸甲酯的鹽酸鹽，其無需進一步純化即可用於下一步(8g，觀察到m/z：300[M+H]⁺)。 To (S)-2-((S)-2-((tertiary butoxycarbonyl)amino)-4-methylpentanamide)-3-((S)-2-oxopyrrolidine- A stirred solution of methyl 3-yl)propionate (10 g, 25 mmol) in CH ₂ Cl ₂ (20 mL) was added to HCl (4M in 1,4-di

alkane solution, 40mL, 160mmol). The reaction mixture was stirred at room temperature for 12 hours, and then concentrated under reduced pressure to give (S)-2-((S)-2-amino-4-methylpentanamide)-3-((S )-2-oxopyrrolidin-3-yl)propanoic acid methyl ester hydrochloride which was used in the next step without further purification (8 g, observed m/z: 300 [M+H] ⁺ ).

Step (4): (S)-2-((S)-2-(9-Hydroxy-9H-oxo-9-formamido)-4-methylpentanamide)-3-((S) -2-Oxopyrrolidin-3-yl)propionic acid methyl ester

To a stirred suspension of 9-hydroxy- 9H -tertilene-9-carboxylic acid (5.0 g, 22.1 mmol) in _CH2Cl2 (20 _mL ) was added HATU (13.6 g, 28.8 mmol) at 0 °C. After 20 minutes, (S)-2-((S)-2-amino-4-methylpentanamide)-3-((S)-2-oxopyrrolidin-3-yl)propane was added A solution of methyl ester hydrochloride (11.1 g) in DMF (10 mL), followed by the addition of N,N -diisopropylethylamine (15.4 mL, 88.5 mmol). The reaction was stirred at 0 °C for 3 hours. The reaction mixture was diluted with saturated aqueous ammonium chloride (25 mL) and the layers were separated. The aqueous layer was further extracted with _CH2Cl2 (2 _x 10 mL). The combined organic phases were washed with saturated aqueous sodium bicarbonate (25 mL), _H2O (25 mL), brine solution (25 mL), dried over anhydrous sodium sulfate and concentrated in vacuo. Purification of the residue by normal phase SiO ₂ chromatography (0-5% MeOH/CH ₂ Cl ₂ ) afforded (S)-2-((S)-2-(9-hydroxy-9H-fennel-9-carba Amino)-4-methylpentanamide)-3-((S)-2-oxopyrrolidin-3-yl)propanoic acid methyl ester (6 g, 54% yield, observed m/z: 508[M+H] ⁺ ).

Step (5): 9-Hydroxy-N-((S)-1-(((S)-1-hydroxy-3-((S)-2-oxopyrrolidin-3-yl)propane-2- Base) amino)-4-methyl-1-oxopentan-2-yl)-9H-stilbene-9-formamide

To (S)-2-((S)-2-(9-hydroxy-9H-stilbene-9-formamido)-4-methylpentanamide)-3-((S) A stirred solution of methyl-2-oxopyrrolidin-3-yl)propanoate (2 g, 3.9 mmol) in CH ₂ Cl ₂ (20 mL) was added dropwise to LiBH ₄ (2M in THF, 4 mL, 7.9 mmol) , for 5 minutes. The reaction was stirred at 0 °C for 2 hours. The reaction mixture was quenched with saturated aqueous ammonium chloride and extracted with EtOAc (2 x 100 mL). The combined organic phases were washed with brine solution (20 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure. The obtained crude material was purified by normal phase _SiO2 chromatography (0-10% MeOH/ _CH2Cl2 ) to give 9 _- hydroxy- N -(( S )-1-((( S )-1-hydroxy- 3-(( S )-2-oxopyrrolidin-3-yl)propan-2-yl)amino)-4-methyl-1-oxopentane-2-yl)-9H-fennel-9 - Formamide (940 mg, 50% yield, observed m/z: 480 [M+H] ⁺ ).

Step (6): 9-Hydroxy-N-((S)-4-methyl-1-oxo-1-(((S)-1-oxo-3-((S)-2- Oxypyrrolidin-3-yl)propan-2-yl)amino)pentan-2-yl)-9H-fen-9-carboxamide

9-Hydroxy- N -(( S )-1-((( S )-1-hydroxyl-3-(( S )-2-oxopyrrolidin-3-yl)propane-2- Stirring of (1.5 g, 3.1 mmol) in CH ₂ Cl ₂ (15 mL) The solution was added _NaHCO3 (520 mg, 6.2 mmol), followed by the dropwise addition of Dess-Martin periodate (2.6 g, 6.3 mmol) over 5 min. The reaction was stirred at room temperature for 2 hours. The mixture was quenched with saturated aqueous sodium bicarbonate (10 mL), and extracted with _CH2Cl2 (2 x 100 mL) _. The combined organic phases were washed with brine solution (10 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by normal phase _SiO2 chromatography (0-10% MeOH/ _CH2Cl2 ) to afford 9-hydroxy- N -( ₍ S )-4-methyl-1-oxo-1-( (( S )-1-oxo-3-(( S )-2-oxopyrrolidin-3-yl)propan-2-yl)amino)pentan-2-yl)-9H-fennel- 9-Formamide (900 mg, 60% yield, observed m/z: 478 [M+H] ⁺ ).

Step (7): (3S)-3-((S)-2-(9-Hydroxy-9H-oxo-9-formamido)-4-methylpentanamide)-1-(methylamino )-1-oxo-4-((S)-2-oxopyrrolidin-3-yl)butane-2-yl acetate

To 9-hydroxy- N -(( S )-4-methyl-1-oxo-1-((( S )-1-oxo-3-(( S )-2-oxopyrrolidine A stirred solution of -3-yl)propan-2-yl)amino)pentan-2-yl)-9H-fluorene-9-carboxamide (500 mg, 1.1 mmol) in _CH2Cl2 (5 _mL ) was added Glacial acetic acid (0.12 mL, 2.09 mmol) and isocyanomethane (1.6M in _CH2Cl2 , 1.3 _mL , 2.08 mmol). The reaction was stirred at room temperature for 24 hours. The mixture was quenched with saturated aqueous sodium bicarbonate (50 mL), and extracted with _CH2Cl2 (2 x 100 mL) _. The combined organic phases were washed with saturated aqueous brine solution (50 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure. Purification of the residue by normal phase SiO ₂ chromatography (0-10% MeOH/CH ₂ Cl ₂ ) afforded ( 3S )-3-(( S )-2-(9-hydroxy-9H-terrene-9- Formamido)-4-methylpentanamide)-1-(methylamino)-1-oxo-4-(( S )-2-oxopyrrolidin-3-yl)butane- 2-yl acetate (200 mg, 33%, observed m/z: 579 [M+H] ⁺ ).

Step (8): 9-Hydroxy-N-((2S)-1-(((2S)-3-Hydroxy-4-(methylamino)-4-oxo-1-((S)-2 -Oxopyrrolidin-3-yl)butane-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9H-oxo-9-formamide

To (3 S )-3-(( S )-2-(9-Hydroxy-9H-oxo-9-formamido)-4-methylpentanamide)-1-(methylamino)-1 -Oxy-4-(( S )-2-oxopyrrolidin-3-yl)butan-2-yl acetate (200 mg, 0.35 mmol) in MeOH:H ₂ O (5:1, 10 mL ) was added LiOH monohydrate (76 mg, 1.73 mmol) and the reaction was stirred at room temperature for 1 h. The mixture was acidified to pH 4 with HCl (1N) and extracted with 10% _MeOH in _CH2Cl2 (2 x 100 mL). The combined organic extracts were washed with brine solution (50 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 9-hydroxy- N -(( 2S )-1-((( 2S )-3- Hydroxy-4-(methylamino)-4-oxo-1-(( S )-2-oxopyrrolidin-3-yl)butane-2-yl)amino)-4-methyl- 1-oxopentan-2-yl)-9H-tertil-9-carboxamide (160 mg, 86% yield, observed m/z: 537 [M+H] ⁺ ).

Step (9): 9-Hydroxy-N-((S)-4-methyl-1-(((S)-4-(methylamino)-3,4-dioxo-1-((S) -2-oxopyrrolidin-3-yl)butane-2-yl)amino)-1-oxopentane-2-yl)-9H-oxo-9-formamide

9-Hydroxy- N -((2 S )-1-(((2 S )-3-hydroxy-4-(methylamino)-4-oxo-1-(( S ) -2-oxopyrrolidin-3-yl)butane-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9H-oxo-9-formamide ( 170 mg, 0.32 mmol) in _CH2Cl2 (3 mL) was added _NaHCO3 (39 mg _, 0.48 mmol) followed by Dess-Martin periodate (200 mg, 0.47 mmol). The resulting mixture was stirred at room temperature for 2 hours. The mixture was diluted with H ₂ O (100 mL), and extracted with CH ₂ Cl ₂ (2×100 mL). The combined organic phases were washed with brine solution (50 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure. Purification of the residue by reverse phase HPLC afforded 9-hydroxy- N -(( S )-4-methyl-1-((( S )-4-(methylamino)-3,4-dioxo-1- (( S )-2-oxopyrrolidin-3-yl)butan-2-yl)amino)-1-oxopentan-2-yl)-9H-oxopyrrolidin-9-formamide (50mg , yield 29%, observed m/z: 535[M+H] ⁺ ); ¹ H NMR (400MHz, DMSO-d ₆ ): δ 8.67-8.62 (m, 1H), 8.19 (d, 1H), 7.76(t,2H), 7.66(s,1H), 7.52-7.21(m,8H), 6.78(bs,1H), 5.06(t,1H), 4.37(t,1H), 3.16-2.99(m, 2H), 2.67-2.64 (m, 3H), 2.32-2.13 (m, 2H), 1.89-1.49 (m, 5H), 0.94-0.83 (m, 6H).

Example 4: N -(( S )-1-((( S )-4-amino-3,4-dioxo-1-(( S )-2-oxopyrrolidin-3-yl)butane Alkyl-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-formamide (compound 6)

Step (1): (3S)-1-((2,4-Dimethoxybenzyl)amino)-3-((S)-2-(9-Hydroxy-9H-oxo-9-formyl Amino)-4-methylpentanamide)-1-oxo-4-((S)-2-oxopyrrolidin-3-yl)butane-2-yl acetate

To 9-hydroxy- N -((S)-4-methyl-1-oxo-1-(( S )-1-oxo-3-(( S )-2-oxo Pyrrolidin-3-yl)propan-2-yl)amino)pentan-2-yl)-9H-stilbene-9-carboxamide (400mg, 0.84mmol) in CH ₂ Cl ₂ (4mL) The stirred solution was added to ice-cold AcOH (0.1 mL, 1.67 mmol), followed by 1-(isocyanomethyl)-2,4-dimethoxybenzene (0.16 mL, 0.92 mmol). The reaction was stirred for 24 hours. The mixture was quenched with saturated aqueous sodium bicarbonate (50 mL), and extracted with _CH2Cl2 (2 x 100 mL) _. The combined organic phases were washed with brine solution (50 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by normal phase _SiO2 chromatography (0-10% MeOH/ _CH2Cl2 ) to afford ( ₍ 3S )-1-((2,4-dimethoxybenzyl)amino)- 3-(( S )-2-(9-Hydroxy-9H-oxo-9-formamido)-4-methylpentanamide)-1-oxo-4-(( S )-2- Oxypyrrolidin-3-yl)butan-2-yl acetate (450 mg, 45% yield, observed m/z: 715 [M+H] ⁺ ).

Step (2): N-((2S)-1-(((2S)-4-((2,4-dimethoxybenzyl)amino)-3-hydroxy-4-oxo-1 -((S)-2-oxopyrrolidin-3-yl)butane-2-yl)amino)-4-methyl-1-oxopentane- 2-yl)-9-hydroxy-9H-fen-9-formamide

To (( 3S )-1-((2,4-dimethoxybenzyl)amino)-3-(( S )-2-(9-hydroxy-9H-trimethoxybenzyl-9-formamido )-4-methylpentanamide)-1-oxo-4-(( S )-2-oxopyrrolidin-3-yl)butane-2-yl acetate (450mg, 0.63mmol) A stirred solution in MeOH:H ₂ O (5:1, 3 mL) was added LiOH monohydrate (132 mg, 3.15 mmol) and the reaction was stirred at room temperature for 1 h. The mixture was acidified with HCl (1N) to pH 4 and extracted with EtOAc (2 x 100 mL). The combined organic phases were washed with brine solution (50 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford N -(( 2S )-1-( ((2 S )-4-((2,4-dimethoxybenzyl)amino)-3-hydroxy-4-oxo-1-(( S )-2-oxopyrrolidine-3 -yl)butane-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-fen-9-carboxamide (350mg, yield 82 %, observed m/z: 673 [M+H] ⁺ ).

Step (3): N-((S)-1-(((S)-4-(cyclopropylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidine -3-yl)butane-2-yl)amino)-4-methyl-1-oxopentane-2-yl)-9-hydroxyl-9H-stilbene-9-formamide

N -((2 S )-1-(((2 S )-4-((2,4-dimethoxybenzyl)amino)-3-hydroxy-4-oxo -1-(( S )-2-oxopyrrolidin-3-yl)butane-2-yl)amino)-4-methyl-1-oxopentane-2-yl)-9-hydroxyl A stirred solution of -9H-Treme-9-formamide (330 mg, 0.49 mmol) in CH ₂ Cl ₂ (5 mL) was added NaHCO ₃ (49 mg, 0.53 mmol), followed by Dess-Martin periodate (249 mg, 0.53 mmol). The reaction was stirred at room temperature for 2 hours. The mixture was quenched with H ₂ O (20 mL), and extracted with CH ₂ Cl ₂ (2×100 mL). The combined organic extracts were washed with brine solution (20 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure. Purification of the residue by reverse phase HPLC gave N -(( S )-1-((( S )-4-((2,4-dimethoxybenzyl)amino)-3,4-dioxo- 1-(( S )-2-oxopyrrolidin-3-yl)butane-2-yl)amino)-4-methyl-1-oxopentane-2-yl)-9-hydroxyl- 9H-Treme-9-formamide (250 mg, 75% yield, observed m/z: 671 [M+H] ⁺ ).

Step (4): N-((S)-1-(((S)-4-amino-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl) Butane-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-formamide

N -((2 S )-1-(((2 S )-4-((2,4-dimethoxybenzyl)amino)-3-hydroxyl-4-oxo-1-( ( S )-2-oxopyrrolidin-3-yl)butane-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-terpineol - A stirred solution of 9-formamide (50 mg, 0.074 mmol) in TFA (0.5 mL) was heated to 100° C. for 30 min. The reaction mixture was cooled to room temperature, neutralized with saturated aqueous sodium bicarbonate (5 mL), and extracted with EtOAc (2 x 10 mL). The combined organic phases were washed with brine solution (10 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford N -(( S )-1-((( S )-4-amino-3,4 -Dioxy-1-(( S )-2-oxopyrrolidin-3-yl)butane-2-yl)amino)-4-methyl-1-oxopentan-2-yl)- 9-Hydroxy-9H-oxo-9-formamide (10 mg, yield 26%, observed m/z: 521[M+H] ⁺ ); ¹ H NMR (400MHz, DMSO-d ₆ ): δ 8.68 (d,J=9.2Hz, 1H), 8.61(bs,2H), 8.30(d,J=9.2Hz, 1H), 8.21(d,J=14Hz, 1H), 7.81-7.67(m,4H), 7.51 -7.18(m,6H), 6.86(s,1H), 5.10-5.05(m,1H), 4.55-4.38(m,1H), 3.16-3.03(m,2H), 2.18-1.86(m,2H), 1.69-1.55 (m, 4H), 0.94-0.85 (m, 6H).

Example 5: (2 S ) -N- (4-(cyclopropylamino)-3,4-dioxo-1-(( S )-2-oxopyrrolidin-3-yl)butane- 2-yl)-2-(2-hydroxy-2,2-diphenylacetamido)-4-methylpentanamide (compound 7)

With appropriate aldehydes and isocyanides with respect to 9-hydroxy- N -(( S )-4-methyl-1-((( S )-4-(methylamino)-3,4-dioxo- 1-(( S )-2-oxopyrrolidin-3-yl)butan-2-yl)amino)-1-oxopentan-2-yl)-9H-oxopyrrolidin-9-formamide A similar manner was described to prepare ( 2S ) -N- (4-(cyclopropylamino)-3,4-dioxo-1-(( S )-2-oxopyrrolidin-3-yl) Butan-2-yl)-2-(2-hydroxy-2,2-diphenylacetamido)-4-methylpentanamide; observed m/z: 563[M+H] ⁺ ; ¹ H NMR (400MHz, DMSO-d ₆ ): δ 8.75(d,1H), 8.64(d,1H), 7.92(d,1H), 7.67(s,1H), 7.39-7.24(m,10H), 6.84(bs,1H), 5.02(bs,1H), 4.40(d,1H), 3.14(d,1H), 3.05(d,1H), 2.74-2.72(m,1H), 2.4-2.3(m, 1H), 2.3-2.2(m, 1H), 1.92-1.83(m, 1H), 1.75-1.45(m, 5H), 0.86-0.78(m, 6H), 0.66-0.56(m, 4H).

Example 6: N -(( S )-1-((( S )-4-(ethylamino)-3,4-dioxo-1-(( S )-2-oxopyrrolidine-3- Base) butane-2-yl) amino)-4-methyl-1-oxopentane-2-yl)-9-hydroxyl-9H-stilbene-9-formamide (compound 8)

With appropriate aldehydes and isocyanides with respect to 9-hydroxy- N -(( S )-4-methyl-1-((( S )-4-(methylamino)-3,4-dioxo- 1-(( S )-2-oxopyrrolidin-3-yl)butan-2-yl)amino)-1-oxopentan-2-yl)-9H-oxopyrrolidin-9-formamide N -(( S )-1-((( S )-4-(ethylamino)-3,4-dioxo-1-(( S )-2-oxopyrrolidine) was prepared in a similar manner as described -3-yl)butane-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-oxo-9-carboxamide; observed m /z: 549[M+H] ⁺ ; ¹ H NMR (400MHz, DMSO-d ₆ ): δ 8.75-8.62(m, 1H), 8.24-8.18(m, 1H), 7.78-7.66(m, 3H) , 7.51-7.21(m,7H), 6.79(bs,1H), 5.06-4.36(m,2H), 2.96-3.17(m,4H), 2.32-1.5(m,8H), 1.07-0.83(m, 9H).

Example 7: N -((2 S )-3-cyclohexyl-1-((4-(methylamino)-3,4-dioxo-1-(( S )-2-oxopyrrolidine- 3-yl)butane-2-yl)amino)-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-formamide (compound 9)

With appropriate aldehydes and isocyanides with respect to 9-hydroxy- N -(( S )-4-methyl-1-((( S )-4-(methylamino)-3,4-dioxo- 1-(( S )-2-oxopyrrolidin-3-yl)butan-2-yl)amino)-1-oxopentan-2-yl)-9H-oxopyrrolidin-9-formamide N -(( 2S )-3-cyclohexyl-1-((4-(methylamino)-3,4-dioxo-1-(( S )-2-oxo Pyrrolidin-3-yl)butan-2-yl)amino)-1-oxopropan-2-yl)-9-hydroxy-9H-oxo-9-carboxamide; observed m/z: 575 [M+H] ⁺ ; ¹ H NMR (400MHz, DMSO-d ₆ ): δ 8.67-8.59 (m, 1H), 8.22-8.16 (m, 2H), 7.78-7.66 (m, 3H), 7.51-7.23 (m,6H), 6.79(s,1H), 5.04-5.02(m,1H), 4.41-4.38(m,1H), 3.31-3.02(m,3H), 2.60(d,J=4.4Hz, 3H ), 2.32-1.89 (m, 3H), 1.86-1.55 (m, 8H), 1.33-0.81 (m, 8H).

Example 8: N -(( S )-1-((( S )-4-amino-3,4-dioxo-1-(( S )-2-oxopyrrolidin-3-yl)butane Alkyl-2-yl)amino)-3-cyclohexyl-1-oxopropan-2-yl)-9-hydroxyl-9H-oxo-9-carboxamide (compound 10)

With appropriate aldehydes and isocyanides with respect to 9-hydroxy- N -(( S )-4-methyl-1-((( S )-4-(methylamino)-3,4-dioxo- 1-(( S )-2-oxopyrrolidin-3-yl)butan-2-yl)amino)-1-oxopentan-2-yl)-9H-oxopyrrolidin-9-formamide N -(( S )-1-((( S )-4-amino-3,4-dioxo-1-(( S )-2-oxopyrrolidine-3- yl)butan-2-yl)amino)-3-cyclohexyl-1-oxopropan-2-yl)-9-hydroxyl-9H-oxo-9-carboxamide; observed m/z: 561 [M+H] ⁺ ; ¹ H NMR (400MHz, DMSO-d ₆ ): δ 8.57-8.42 (m, 1H), 8.23-8.08 (m, 2H), 7.80-7.17 (m, 6H), 7.51-7.23 (m,4H), 6.79(d,J=4Hz, 1H), 5.07-5.05(m,1H), 4.42-4.39(m,1H), 3.31-3.02(m,2H), 2.32-1.49(m, 12H), 1.35-0.81 (m, 6H).

Example 9: N-(1-((4-(cyclopropylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2 -yl)amino)-4-methyl-1-oxopentane-2-yl)-9-hydroxyl-9H-stilbene-9-formamide (compound 11)

With appropriate aldehydes and isocyanides with respect to 9-hydroxy- N -(( S )-4-methyl-1-((( S )-4-(methylamino)-3,4-dioxo- 1-(( S )-2-oxopyrrolidin-3-yl)butan-2-yl)amino)-1-oxopentan-2-yl)-9H-oxopyrrolidin-9-formamide N-(1-((4-(cyclopropylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butane Alk-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide; observed m/z: 561 [M +H] ⁺ ; ¹ H NMR (400MHz, DMSO-d ₆ ): δ 8.77 (d, J=5.2Hz, 1H), 8.62 (d, J=7.2Hz, 1H), 8.18 (d, J=8.8Hz , 1H), 8.0-7.1(m,8H), 6.8(bs,1H), 5.1-5.05(m,1H), 4.4-4.37(m,3H), 3.16-3.02(m,1H), 2.77-2.74 (m,1H), 2.38-2.3(m,1H), 2.2-2.1(m,1H), 1.95-1.85(m,1H), 1.75-1.50(m,5H), 0.93(d,J=6.4Hz , 3H), 0.86 (d, J=6.4Hz, 3H), 0.67-0.59 (m, 4H).

Example 10: N -(( S )-3-cyclohexyl-1-oxo-1-((( S )-1-oxo-3-(( S )-2-oxopyrrolidine- 3-yl)propan-2-yl)amino)propan-2-yl)-9-hydroxyl- 9H -tila-9-formamide (compound 12)

With appropriate aldehydes and isocyanides with respect to 9-hydroxy- N -(( S )-4-methyl-1-((( S )-4-(methylamino)-3,4-dioxo- 1-(( S )-2-oxopyrrolidin-3-yl)butan-2-yl)amino)-1-oxopentan-2-yl)-9H-oxopyrrolidin-9-formamide N -(( S )-3-cyclohexyl-1-oxo-1-((( S )-1-oxo-3-(( S )-2-oxo Pyrrolidin-3-yl)propan-2-yl)amino)propan-2-yl ) -9-hydroxy-9H-stilbene-9-carboxamide; observed m/z: 518 [M+H] ⁺ ; ¹ H NMR (400MHz, DMSO-d ₆ ): δ 9.43(s,1H), 8.21(m,1H), 7.83-7.24(m,9H), 6.77(s,1H), 4.41-4.35(m ,2H), 3.91-3.73(m,1H), 3.38-2.97(m,4H), 2.29-2.08(m,2H), 1.99-0.74(m,14H).

Example 11: (1 S ,3a R ,6a S ) -N -(( S )-4-hydroxy-3-oxo-1-(( S )-2-oxopyrrolidin-3-yl) Butane-2-yl)-2-(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide (compound 13)

Step (1): ((Benzyloxy)methyl)tributylstannane

To a solution of tributyltin hydride (100 g, 346 mmol) in dry THF (350 mL) was added LDA (2M in THF, 173 mL, 346 mmol) dropwise over 15 min at -10 °C under nitrogen. After stirring for 30 min, a solution of benzylchloromethyl ether (23 mL, 165 mmol) in THF (50 mL) was added slowly, keeping the internal reaction temperature below -10 °C, and the mixture was stirred for 1 h. The reaction was quenched with saturated aqueous ammonium chloride (250 mL), extracted with EtOAc (2 x 500 mL), washed with brine solution (250 mL) and concentrated under reduced pressure. The residue was purified by _Si02 chromatography (0-20% EtOAc/hexanes) to afford ((benzyloxy)methyl)tributylstannane (50 g, 52% yield). ¹ H NMR (400MHz, CDCl ₃ ): δ 7.33-7.26 (m, 5H), 4.42 (s, 2H), 3.75 (s, 2H), 1.57-1.49 (m, 6H), 1.34-1.25 (m, 6H) ), 0.93-0.83 (m,15H).

Step (2): ((S)-4-(Benzyloxy)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)amine Tertiary butyl formate:

To a stirred solution of ((benzyloxy)methyl)tributylstannane (49 g, 119 mmol) in dry THF (500 mL) was slowly added n -BuLi (2.3 M in hexanes) at -78 °C under nitrogen over 15 min. , 52mL, 120mmol). After stirring at -78°C for 30 min, ((S)-1-(methoxy(methyl)amino)-1-oxo-3-((S)-2-oxo Substituted pyrrolidin-3-yl) propan-2-yl) tert-butyl carbamate (according to Hoffman, RL et al., J. Med. Chem. 2020, 63 , 12725 and Hayashi, Y. et al., Eur .J.Med.Chem , 2013, 65,436 prepared by the procedure; 12.5 g, 39.6 mmol) in THF (20 mL) and the solution was stirred for 3 hours. The reaction was quenched with saturated aqueous ammonium chloride (250 mL) and slowly warmed to room temperature. The suspension was extracted with EtOAc (2 x 500 mL). The combined organic phases were dried over anhydrous sodium sulfate and concentrated under reduced pressure. Purification of the residue by _SiO2 chromatography (20-100% EtOAc/hexanes) afforded ((S)-4-(benzyloxy)-3-oxo-1-((S)-2-oxo tert-butylpyrrolidin-3-yl)butan-2-yl)carbamate (9.5 g, 64% yield, observed m/z: 377 [M+H] ⁺ ).

Step (3): (S)-3-((S)-2-amino-4-(benzyloxy)-3-oxobutyl)pyrrolidin-2-one hydrochloride

烷溶液，50mL)，並將混合物攪拌2小時。將反應混合物在減壓下濃縮。用二乙醚(100mL)研磨油狀殘餘物並通過過濾收集所得固體。將有機相在減壓下濃縮，用二乙醚(100mL)研磨並通過過濾收集所得固體。將合併後的固體在真空下乾燥過夜，得到(S)-3-((S)-2-胺基-4-(苄氧基)-3-氧代丁基)吡咯啶-2-酮鹽酸鹽，其無需進一步純化即可使用(6.5g，觀察到m/z：277[M+H]⁺)。 To ((S)-4-(benzyloxy)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)amine at 0°C To a stirred solution of tert-butyl carbamate (9.5 g, 25.3 mmol) in CH ₂ Cl ₂ (95 mL) was added HCl (4N 1,4-di

alkane solution, 50 mL), and the mixture was stirred for 2 hours. The reaction mixture was concentrated under reduced pressure. The oily residue was triturated with diethyl ether (100 mL) and the resulting solid was collected by filtration. The organic phase was concentrated under reduced pressure, triturated with diethyl ether (100 mL) and the resulting solid collected by filtration. The combined solids were dried under vacuum overnight to give ( S )-3-(( S )-2-amino-4-(benzyloxy)-3-oxobutyl)pyrrolidin-2-one salt Acid salt, which was used without further purification (6.5 g, observed m/z: 277 [M+H] ⁺ ).

Step (4): (1S,3aR,6aS)-2-(9-Hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxylic acid ethyl ester:

To a stirred solution of 9-hydroxy-9H-tertilene-9-carboxylic acid (0.5 g, 2.2 mmol) in DMF (5 mL) was added HATU (1.68 g, 4.42 mmol) at 0 °C under _N2 atmosphere. After stirring for 30 min, ethyl (1S,3aR,6aS)-octahydrocyclopenta[c]pyrrole-1-carboxylate hydrochloride (0.97 g, 4.42 mmol) in DMF (0.5 mL) and Solution in N -methylmorpholine (1.2 mL, 11.1 mmol). The reaction mixture was stirred at room temperature under N ₂ atmospheres for 1.5 h. The reaction was diluted with _H2O (30 mL) and extracted with EtOAc (2 x 250 mL). The combined organic phases were washed with _H2O (2 x 50 mL), brine solution (2 x 50 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure. Purification of the residue by _SiO2 chromatography (20-100% EtOAc/hexanes) afforded ( 1S , 3aR , 6aS )-2-(9-hydroxy-9H-tertene-9-carbonyl)octahydrocyclo Penta[c]pyrrole-1-carboxylate (760 mg, 88% yield, observed m/z: 392 [M+H] ⁺ ).

Step (5): (1S,3aR,6aS)-2-(9-Hydroxy-9H-fennel-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxylic acid

(1S,3aR,6aS)-2-(9-Hydroxy-9H-oxo-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxylic acid ethyl ester (390mg, 0.99 A vigorously stirred solution of mmol) in MeOH (4 mL) was added NaOH (4M in water, 1.93 mL, 7.7 mmol). The resulting solution was stirred at 0 °C for 3 hours. The reaction mixture was neutralized with HCl (1N) while maintaining the internal temperature below 10°C. Excess methanol was removed under reduced pressure and the aqueous layer was acidified to pH~4-5 with HCl (2N). The mixture was extracted with EtOAc (2 x 400 mL). The combined organic layers were washed with brine solution (250 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure to give (1 S , 3a R , 6a S )-2-(9-hydroxy-9H-fennel-9- Carbonyl) octahydrocyclopenta[c]pyrrole-1-carboxylic acid which was used without further purification (390 mg, observed m/z: 364 [M+H] ⁺ ).

Step (6): (1S,3aR,6aS)-N-((S)-4-(benzyloxy)-3-oxo-1-((S)-2-oxopyrrolidine-3- Base) butane-2-yl)-2-(9-hydroxyl-9H-oxene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide

To ( ₁ S , 3a R , 6a S )-2-(9-hydroxy-9H-fennel-9-carbonyl) octahydrocyclopenta[c]pyrrole-1-carboxylic acid ( 380 mg) in DMF (4 mL) was added to a stirred solution of HATU (795 mg, 2.1 mmol). After stirring for 30 min, ( S )-3-(( S )-2-amino-4-(benzyloxy)-3-oxobutyl)pyrrolidin-2-one was added dropwise under _N atmosphere A solution of hydrochloride (392 mg, 1.25 mmol) in DMF (0.5 mL) was added followed by the addition of N -methylmorpholine (0.57 mL, 5.23 mmol). The reaction mixture was stirred at room temperature for 2 hours. The reaction mixture was diluted with _H2O (25 mL), and extracted with EtOAc (2 x 200 mL). The combined organic phases were washed with brine solution (2 x 100 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was _purified by _SiO2 chromatography (0-10% MeOH/ _CH2Cl2 ) to afford ( 1S , 3aR , 6aS ) -N -(( S )-4-(benzyloxy)-3 -Oxy-1-(( S )-2-oxopyrrolidin-3-yl)butan-2-yl)-2-(9-hydroxyl-9H-oxo-9-carbonyl)octahydrocyclopenta [c]pyrrole-1-carboxamide as a pale yellow gum (280 mg from (1S,3aR,6aS)-2-(9-hydroxy-9H-oxene-9-carbonyl)octahydrocyclopenta[c]pyrrole - 43% yield of 1-carboxylic acid, observed m/z: 622 [M+H] ⁺ ).

Step (7): (1S,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane -2-yl)-2-(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide

(1 S ,3a R ,6a S ) -N -(( S )-4-(benzyloxy)-3-oxo-1-(( S )-2-oxopyrrolidin-3-yl )butane-2-yl)-2-(9-hydroxyl-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide (280mg, 0.450mmol) and palladium on carbon catalyst (10 % on carbon, 0.25 g, 2.3 mmol) in MeOH (3 mL) was stirred at room temperature under hydrogen atmosphere at 50 psi for 3 hours. The mixture was filtered through CELITE®, washed with MeOH (200 mL) and concentrated under reduced pressure. Purification of the residue by reverse phase HPLC gave (1S, 3aR , 6aS ) -N -(( S )-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidine- 3-yl)butane-2-yl)-2-(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide (28 mg, yield 12%, observed to m/z: 532[M+H] ⁺ ); ¹ H NMR (400MHz, DMSO-d ₆ ): δ 8.46(d,1H), 7.84-7.77(m,2H), 7,65-7.62(m ,1H), 7.47-7.41(m,2H), 7.35-7.31(m,3H), 7.23(d,1H), 5.99(s,1H), 5.09-5.08(m,1H), 4.47-4.45(m ,1H), 4.23-4.15(m,3H), 3.20-3.15(m,2H), 2.49-2.19(m,6H), 1.92-1.88(m,1H), 1.68-1.31(m,7H), 1.15 -1.13(m,1H).

Example 12: 9-Hydroxy- N -(( S )-1-((( S )-4-hydroxy-3-oxo-1-(( S )-2-oxopyrrolidin-3-yl )butane-2-yl)amino)-4,4-dimethyl-1-oxopentane-2-yl)-9H-stilbene-9-formamide (compound 14)

By coupling (S)-3-((S)-2-amino-4-(benzyloxy)-3-oxobutyl)pyrrolidin-2-one hydrochloride with an appropriate carboxylic acid to Regarding (1 S ,3a R ,6a S ) -N -(( S )-4-hydroxy-3-oxo-1-(( S )-2-oxopyrrolidin-3-yl)butane- 2-yl)-2-(9-hydroxy-9H-oxo-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide was prepared in a manner similar to that described for 9-hydroxy- N -(( S )-1-((( S )-4-hydroxy-3-oxo-1-(( S )-2-oxopyrrolidin-3-yl)butane-2-yl)amino)-4 ,4-Dimethyl-1-oxopentan-2-yl)-9H-fen-9-formamide; observed m/z: 522[M+H] ⁺ ; ¹ H NMR (400MHz, DMSO -d ₆ ): δ 8.41(d,1H), 8.11(d,1H), 7.78-7.75(m,2H), 7.63(s,1H), 7.41-7.34(m,3H), 7.29-7.23(m ,3H), 6.80(s,1H), 5.14(t,1H), 4.51-4.48(m,1H), 4.39-4.34(m,1H), 4.19-4.15(m,2H), 3.12(t,1H ), 2.95-2.89(m,1H), 2.21-1.56(m,7H), 0.96(s,9H).

Example 13: (3 S )-N-(4-hydroxyl-3-oxo-1-(( S )-2-oxopyrrolidin-3-yl)butane-2-yl)-2- (9-Hydroxy- 9H -Oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide (compound 15)

By coupling (S)-3-((S)-2-amino-4-(benzyloxy)-3-oxobutyl)pyrrolidin-2-one hydrochloride with an appropriate carboxylic acid to Regarding (1 S ,3a R ,6a S ) -N -(( S )-4-hydroxy-3-oxo-1-(( S )-2-oxopyrrolidin-3-yl)butane- N- (4-hydroxy-3- Oxy-1-(( S )-2-oxopyrrolidin-3-yl)butane-2-yl)-2-(9-hydroxyl-9H-oxo-9-carbonyl)-2-aza Bicyclo[2.2.2]octane-3-carboxamide; Observed m/z: 532[M+H] ⁺ ; ¹ H NMR (400MHz, DMSO-d ₆ ): δ 8.59(d,1H), 7.84 -7.63(m,3H), 7.45-7.22(m,5H), 5.97(bs,1H), 5.09-5.06(m,1H), 4.6-4.45(m,1H), 4.37(t,1H), 4.18 -4.25(m,2H), 2.8-3.2(m,3H), 3.06-3.04(m,1H), 2.3-0.7(m,14H).

Example 14: N -(( S )-3-cyclohexyl-1-((( S )-4-hydroxy-3-oxo-1-(( S )-2-oxo Pyrrolidin-3-yl)butane-2-yl)amino)-1-oxopropan-2-yl)-9-hydroxyl-9H-oxo-9-formamide (compound 16)

By coupling (S)-3-((S)-2-amino-4-(benzyloxy)-3-oxobutyl)pyrrolidin-2-one hydrochloride with an appropriate carboxylic acid to Regarding (1 S ,3a R ,6a S ) -N -(( S )-4-hydroxy-3-oxo-1-(( S )-2-oxopyrrolidin-3-yl)butane- N -(( S )-3- Cyclohexyl-1-((( S )-4-hydroxy-3-oxo-1-(( S )-2-oxopyrrolidin-3-yl)butane-2-yl)amino)- 1-Oxopropan-2-yl)-9-hydroxy-9H-oxo-9-carboxamide; observed m/z: 548[M+H] ⁺ ; ¹ H NMR (400MHz, DMSO-d ₆ ) : δ 8.45(d,1H), 8.23(d,1H), 7.78-7.75(m,2H), 7.63(s,1H), 7.41-7.23(m,7H), 6.79(bs,1H), 4.49- 4.38(m,2H), 4.25-4.12(m,2H), 3.11(t,1H), 2.96(d,1H), 2.19(d,1H), 2.06(t,1H), 1.95-1.85(m, 1H), 1.75-1.56 (m, 9H), 1.35 (bs, 1H), 1.23-1.09 (m, 3H), 0.95-0.86 (m, 2H).

Example 15: (1 S ,3a R ,6a S ) -N -(( S )-4-hydroxy-3-oxo-1-(( S )-2-oxopyrrolidin-3-yl) Butane-2-yl)-2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide (compound 17)

By coupling (S)-3-((S)-2-amino-4-(benzyloxy)-3-oxobutyl)pyrrolidin-2-one hydrochloride with an appropriate carboxylic acid to Regarding (1 S ,3a R ,6a S ) -N -(( S )-4-hydroxy-3-oxo-1-(( S )-2-oxopyrrolidin-3-yl)butane- 2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide was prepared in a similar manner as described for (1 S , 3a R , 6a S ) -N -(( S )-4-hydroxyl-3-oxo-1-(( S )-2-oxopyrrolidin-3-yl)butane-2-yl)-2-(4- Methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; observed m/z: 497[M+H] ⁺ ; ¹ H NMR (400MHz, DMSO- d ₆ ): δ 11.48(bs,1H), 8.72-8.36(m,1H), 7.17-6.81(m,3H), 6.52-6.44(m,1H), 5.14-4.82(m,1H), 4.49- 3.59 (m, 9H), 3.13-2.32 (m, 5H), 1.94-1.37 (m, 11H).

Example 16: (1 S ,3a R ,6a S ) -N -(( S )-4-hydroxyl-3-oxo-1-(( S )-2-oxopyrrolidin-3-yl) Butane-2-yl)-2-(1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide (Compound 18)

By coupling (S)-3-((S)-2-amino-4-(benzyloxy)-3-oxobutyl)pyrrolidin-2-one hydrochloride with an appropriate carboxylic acid to Regarding (1 S ,3a R ,6a S ) -N -(( S )-4-hydroxy-3-oxo-1-(( S )-2-oxopyrrolidin-3-yl)butane- 2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide was prepared in a similar manner as described for (1 S , 3a R , 6a S )- N -(( S )-4-hydroxyl-3-oxo-1-(( S )-2-oxopyrrolidin-3-yl)butane-2-yl)-2-(1H- Indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; observed m/z: 467[M+H] ⁺ ; ¹ H NMR (400MHz, DMSO-d ₆ ): δ 11.25 (s,1H), 8.38(d,1H), 7.59-7.58(m,3H), 7.34(s,1H), 7.18(t,1H), 7.03(t,1H), 6.92(bs,1H), 4.77-4.76(m,1H), 4.57-4.43(m,2H), 4.22-4.13(m,3H), 3.75-3.73(m,1H), 3.07-3.05(m,2H), 2.79-2.77(m ,2H), 1.97-1.49(m,10H).

Example 17: N -(( S )-1-((( S )-4-hydroxy-3-oxo-1-(( S )-2-oxopyrrolidin-3-yl)butane- 2-yl)amino)-4-methyl-1-oxopentane-2-yl)-4-methoxy-1-propyl-1H-indole-2-carboxamide (compound 19)

By coupling (S)-3-((S)-2-amino-4-(benzyloxy)-3-oxobutyl)pyrrolidin-2-one hydrochloride with an appropriate carboxylic acid to Regarding (1 S ,3a R ,6a S ) -N -(( S )-4-hydroxy-3-oxo-1-(( S )-2-oxopyrrolidin-3-yl)butane- N -(( S )-1- ((( S )-4-hydroxy-3-oxo-1-(( S )-2-oxopyrrolidin-3-yl)butane-2-yl)amino)-4-methyl- 1-oxopentan-2-yl)-4-methoxy-1-propyl-1H-indole-2-carboxamide; observed m/z: 515[M+H] ⁺ ; ¹ H NMR (400MHz, DMSO-d ₆ ): δ 8.47(d,1H), 8.39(d,1H), 7.62(s,1H), 7.29(s,1H), 7.19-7.10(m,3H), 6.56( d,1H), 5.05(t,1H), 4.48-4.40(m,4H), 4.23-4.15(m,2H), 3.89(s,3H), 3.14-3.03(m,2H), 2.35-2.17( m,1H), 2.11-2.15(m,1H), 1.95-1.92(m,1H), 1.73-1.51(m,8H), 0.95-0.88(m,6H), 0.76(t,1H).

Example 18: N -(( S )-1-((( S )-4-hydroxy-3-oxo-1-(( S )-2-oxopyrrolidin-3-yl)butane- 2-yl)amino)-4-methyl-1-oxopentane-2-yl)-4-methoxy-1-(2-methylallyl)-1H-indole-2- Formamide (compound 20)

By coupling (S)-3-((S)-2-amino-4-(benzyloxy)-3-oxobutyl)pyrrolidin-2-one hydrochloride with an appropriate carboxylic acid to Regarding (1 S ,3a R ,6a S ) -N -(( S )-4-hydroxy-3-oxo-1-(( S )-2-oxopyrrolidin-3-yl)butane- N -(( S )-1- ((( S )-4-hydroxy-3-oxo-1-(( S )-2-oxopyrrolidin-3-yl)butane-2-yl)amino)-4-methyl- 1-oxopentan-2-yl)-4-methoxy-1-(2-methylallyl)-1H-indole-2-carboxamide; observed m/z: 527 [M +H] ⁺ ; ¹ H NMR (400MHz, DMSO-d ₆ ): δ 8.47(d,1H), 8.39(d,1H), 7.62(s,1H), 7.29(s,1H), 7.19-7.10( m,3H), 6.56(d,1H), 5.05(t,1H), 4.48-4.40(m,4H), 4.23-4.15(m,2H), 3.89(s,3H), 3.14-3.03(m, 2H), 2.35-2.17(m,1H), 2.11-2.15(m,1H), 1.95-1.92(m,1H), 1.73-1.51(m,8H), 0.95-0.88(m,6H), 0.76( t,1H).

Example 19: ( S ) -N -(( S )-4-hydroxy-3-oxo-1-(( S )-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(2-Methyl-4H-thieno[3,2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-formamide (compound 21)

By coupling (S)-3-((S)-2-amino-4-(benzyloxy)-3-oxobutyl)pyrrolidin-2-one hydrochloride with an appropriate carboxylic acid to Regarding (1 S ,3a R ,6a S ) -N -(( S )-4-hydroxy-3-oxo-1-(( S )-2-oxopyrrolidin-3-yl)butane- ( S ) -N -(( S )-4-hydroxyl-3-oxo-1-(( S )-2-oxopyrrolidin-3-yl)butane-2-yl)-2-(2-methyl-4H-thieno [3,2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; observed m/z: 487[M+H] ⁺ ; ¹ H NMR (400MHz,DMSO-d ₆ ): δ 11.43(s,1H), 8.38(s,1H), 7.64(s,1H), 6.69(s,1H), 4.66-3.86(m,4H), 3.25-2.61 (m, 5H), 2.37-1.23 (m, 15H).

Example 20: ( S )-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl) -N -(( S )-4-hydroxy-3-oxo- 1-(( S )-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide (compound 22)

By coupling (S)-3-((S)-2-amino-4-(benzyloxy)-3-oxobutyl)pyrrolidin-2-one hydrochloride with an appropriate carboxylic acid to Regarding (1 S ,3a R ,6a S ) -N -(( S )-4-hydroxy-3-oxo-1-(( S )-2-oxopyrrolidin-3-yl)butane- ( S )-2-(3- Chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl) -N -(( S )-4-hydroxy-3-oxo-1-(( S )-2-oxopyrrolidine -3-yl)butan-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide; observed m/z: 507[M+H] ⁺ ; ¹ H NMR ( 400MHz, DMSO-d ₆ ): δ 12.13(s,1H), 8.40(d,1H), 7.63(s,1H), 7.38(s,1H), 6.83(s,1H), 4.66-3.86(m, 4H), 3.19-2.60 (m, 2H), 2.25-1.39 (m, 15H).

Example 21: ( S ) -N -(( S )-4-hydroxy-3-oxo-1-(( S )-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-formamide (compound 23)

By coupling (S)-3-((S)-2-amino-4-(benzyloxy)-3-oxobutyl)pyrrolidin-2-one hydrochloride with an appropriate carboxylic acid to Regarding (1 S ,3a R ,6a S ) -N -(( S )-4-hydroxy-3-oxo-1-(( S )-2-oxopyrrolidin-3-yl)butane- ( S ) -N -(( S )-4-hydroxy-3-oxo-1-(( S )-2-oxopyrrolidin-3-yl)butane-2-yl)-2-(4-methoxy-1H-ind Indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; observed m/z: 497[M+H] ⁺ ; ¹ H NMR (400MHz, DMSO-d ₆ ): δ 11.23(s,1H), 8.28(s,1H), 7.32(s,1H), 7.10-7.02(m,2H), 6.75-6.74(m,2H), 6.50- 6.48(d,1H) , 4.82-4.13 (m, 6H), 3.87 (s, 3H), 2.24-1.48 (m, 15H).

Example 22: ( S ) -N -(( S )-4-hydroxy-3-oxo-1-(( S )-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(3-Methyl-4H-thieno[3,2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-formamide (compound 24)

By coupling ( S )-3-(( S )-2-amino-4-(benzyloxy)-3-oxobutyl)pyrrolidin-2-one hydrochloride with an appropriate carboxylic acid to Regarding (1 S ,3a R ,6a S ) -N -(( S )-4-hydroxy-3-oxo-1-(( S )-2-oxopyrrolidin-3-yl)butane- ( S ) -N -(( S )-4-hydroxyl-3-oxo-1-(( S )-2-oxopyrrolidin-3-yl)butane-2-yl)-2-(3-methyl-4H-thieno [3,2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; observed m/z: 487[M+H] ⁺ ; ¹ H NMR (400MHz,DMSO-d ₆ ): δ 11.44(s,1H), 8.24(d,1H), 7.36(s,1H), 6.90(d,1H), 6.71(d,1H), 4.71-4.37(m ,3H), 4.37-4.02(m,2H), 2.37-1.37(m,19H).

Example 23: ( S )-2-(4,6-difluoro-1H-indole-2-carbonyl) -N -(( S )-4-hydroxyl-3-oxo-1-(( S )-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide (compound 25)

By coupling (S)-3-((S)-2-amino-4-(benzyloxy)-3-oxobutyl)pyrrolidin-2-one hydrochloride with an appropriate carboxylic acid to Regarding (1 S ,3a R ,6a S ) -N -(( S )-4-hydroxy-3-oxo-1-(( S )-2-oxopyrrolidin-3-yl)butane- ( S )-2-(4, 6-Difluoro-1H-indole-2-carbonyl) -N -(( S )-4-hydroxy-3-oxo-1-(( S )-2-oxopyrrolidin-3-yl) Butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide; observed m/z: 503[M+H] ⁺ ; ¹ H NMR (400MHz, DMSO-d ₆ ): δ 11.69(s,1H), 8.30(d,1H), 7.36(s,1H), 7.21-6.98(m,1H), 6.79(s,2H), 4.71-3.94(m,5H), 2.38-1.29(m,16H).

Example 24: (1 S ,3a R ,6a S )-2-(9-fluoro-9H-fennel-9-carbonyl) -N -(( S )-4-hydroxy-3-oxo-1- (( S )-2-oxopyrrolidin-3-yl)butane-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide (compound 26)

By coupling (S)-3-((S)-2-amino-4-(benzyloxy)-3-oxobutyl)pyrrolidin-2-one hydrochloride with an appropriate carboxylic acid to Regarding (1 S ,3a R ,6a S ) -N -(( S )-4-hydroxy-3-oxo-1-(( S )-2-oxopyrrolidin-3-yl)butane- 2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide was prepared in a similar manner as described for (1 S , 3a R , 6a S )-2-(9-fluoro-9H-fennel-9-carbonyl)-N-((S)-4-hydroxyl-3-oxo-1-((S)-2-oxopyrrolidine-3 -yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; observed m/z: 534[M+H] ⁺ ; ¹ H NMR (400MHz, CD ₃ OD): δ 7.78(dd,2H), 7.55-7.44(m,4H), 7.36(t,2H), 4.64(dd,1H), 4.32(d,2H), 4.29(d,1H), 3.05-2.23(m ,5H), 2.14-1.18(m,11H), 0.78(s,1H).

Example 25: (1 S , 3a R , 6a S )-2-(9-Acetamido-9H-Oxime-9-carbonyl) -N -(( S )-4-Hydroxy-3-oxo -1-(( S )-2-oxopyrrolidin-3-yl)butane-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide (compound 27)

Step (1): 9-Acetamido-9H-Treme-9-carboxylic acid

9-Hydroxytilbene-9-carboxylic acid (550 mg, 2.07 mmol) was dissolved in acetonitrile (12 mL) and concentrated sulfuric acid (810 mg, 8.27 mmol) was added dropwise at 0°C. The mixture was stirred at 60 °C for 3 hours, then cooled to room temperature and water (30 mL) was added slowly. The resulting solution was stirred at room temperature for an additional 30 minutes. The aqueous solution was extracted with EtOAc (3 x 30 mL). The combined organic phases were washed with brine (20 mL), dried over anhydrous sodium sulfate, filtered and concentrated under vacuum. To the residue was added _CH2Cl2 (30 mL), followed by hexane (2 mL) and the sample was sonicated _. The resulting precipitate was collected by filtration and dried to give 9-acetamido fluorene-9-carboxylic acid as an off-white solid (465 mg, 84% yield, observed m/z: 268 [M+H] ⁺ ), which did not require It can be used after further purification.

Step (2): (1 S ,3a R ,6a S )-2-(9-Acetamido-9H-Oxyl-9-carbonyl) -N -(( S )-4-Hydroxy-3-oxo Base-1-(( S )-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide

By coupling 9-acetylamino terpene-9-carboxylic acid with the appropriate amine to react with respect to (1 S , 3a R , 6a S ) -N -(( S )-4-hydroxy-3-oxo- - (1 S , 3a R , 6a S )-2-(9-acetamido-9H-oxo-9-carbonyl) -N -(( S )-1 -Cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; observed m/z: 573 [M+ H] ⁺ ; ¹ H NMR (400MHz, CD ₃ OD): δ 7.80(dd,2H), 7.51(d,1H), 7.49-7.43(m,3H), 7.33(dd,2H), 5.03(dd, 1H), 4.19(d,1H), 3.39(m,2H), 2.72(m,1H), 2.51(dd,1H), 2.46-2.23(m,5H), 2.20(d,1H), 1.99-1.84 (m,6H), 1.83-1.73(m,1H), 1.52-1.25(m,5H).

Example 26: (1 S ,3a R ,6a S ) -N -(( S )-4-hydroxy-3-oxo-1-(( S )-2-oxopyrrolidin-3-yl) Butane-2-yl)-2-(5-oxo-2-phenylpyrrolidin-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide (Compounds 28 and 29)

By coupling (1S,3aR,6aS)-octahydrocyclopenta[c]pyrrole-1-carboxylate ethyl ester hydrochloride with an appropriate carboxylic acid to combine with ( 1S , 3aR , 6aS ) -N- (( S )-4-hydroxyl-3-oxo-1-(( S )-2-oxopyrrolidin-3-yl)butane-2-yl)-2-(9-hydroxyl-9H- ( 1S , 3aR , 6aS ) -N -(( S )-4-hydroxy-3 -Oxy-1-(( S )-2-oxopyrrolidin-3-yl)butane-2-yl)-2-(5-oxyl-2-phenylpyrrolidin-2-carbonyl ) octahydrocyclopenta[c]pyrrole-1-carboxamide (mixture of diastereoisomers). The mixture of diastereoisomers was separated by reverse phase HPLC purification to afford each epimer.

Major diastereomer (compound 28) : (faster eluting diastereomer, 6.2 mg, 18% yield): observed m/z: 511 [M+H] ⁺ . ¹ H NMR (400MHz, CD ₃ OD): δ 7.45-7.34(m,5H), 4.64(dd,1H), 4.43-4.29(m,2H), 4.26(d,1H), 3.48(dd,1H) , 3.34(dd,2H), 3.10(m,1H), 2.89 (dd,1H), 2.75-2.59(m,1H), 2.55(d,2H), 2.45(dd,1H), 2.41-2.30(m ,2H), 2.21(m,1H), 2.12-1.99(m,1H), 1.86(m,3H), 1.72-1.48(m,5H).

Minor diastereomer (compound 29) : (slower eluting diastereomer, 2.2 mg, 7% yield): observed m/z: 511 [M+H] ⁺ . ¹ H NMR (400MHz, CD ₃ OD): δ 7.52-7.32(m,5H), 4.62(dd,1H), 4.43-4.23(m,2H), 4.12(dd,1H), 3.35(dd,3H) , 3.04-2.82(m,2H), 2.78-2.55(m,2H), 2.38(m,4H), 2.08(m,1H), 1.96(m,1H), 1.90-1.72(m,4H), 1.72 -1.50(m,3H), 1.37(m,1H).

Example 27: (3 S )-2-(2-cyclopentyl-2-hydroxyl-2-phenylacetyl) -N -(( S )-4-hydroxyl-3-oxo-1-( ( S )-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide (compounds 30 and 31)

Step (1): (3S)-N-((S)-4-(benzyloxy)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane -2-yl)-2-(2-(4-chlorophenyl)-2-cyclopentyl-2-hydroxyacetyl)-2-azabicyclo[2.2.2]octane-3-formyl amine

To a stirred solution of 2-( ₄ -chlorophenyl)-2-cyclopentyl-2-hydroxyacetic acid (350 mg, 1.4 mmol) in DMF (10 mL) was added HATU (784 mg , 2.1 mmol). ( 3S ) -N -[( 2S )-4-(benzyloxy)-3-oxo-1-[( 3S )-2-oxopyrrolidin-3-yl was added dropwise to the mixture A solution of ]butane-2-yl]-2-azabicyclo[2.2.2]octane-3-carboxamide hydrochloride (1 g, 2.1 mmol) in DMF (5 mL), followed by addition of DIPEA (0.96 mL, 5.5 mmol). The reaction mixture was stirred at room temperature for 2 hours and diluted with water (50 mL). The aqueous phase was extracted with EtOAc (2 x 50 mL). The combined organic layers were washed with aqueous brine solution (2 x 50 mL), dried over anhydrous sodium sulfate, filtered, and concentrated in vacuo. The crude residue was purified by normal phase _Si02 column chromatography (70-80% EtOAc/hexanes) to afford the two separated diastereoisomers.

Minor diastereomer (single diastereomer I) : (faster eluting diastereomer, 120 mg, 9% yield): Observed m/z: 650 [M+ H] ⁺ .

Major diastereomer (single diastereomer II) : (slower eluting diastereomer, 320 mg, 24% yield): Observed m/z: 650 [M+H ] ⁺ .

Step (2a): (3S)-2-(2-cyclopentyl-2-hydroxy-2-phenylacetyl)-N-((S)-4-hydroxy-3-oxo-1-( (S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide (compound 30)

To (3 S ) -N -[(2 S )-4-(benzyloxy)-3-oxo-1-[(3 S )-2-oxopyrrolidin-3-yl]butane- 2-yl]-2-[2-(4-chlorophenyl)-2-cyclopentyl-2-hydroxyacetyl]-2-azabicyclo[2.2.2]octane-3-formamide A stirred solution of (minor diastereomer/single diastereomer I, 100 mg, 0.15 mmol) in MeOH (5 mL) was added palladium on carbon catalyst (10% on carbon, 0.1 g, 1 mmol). The reaction mixture was stirred at room temperature under a balloon of hydrogen for 2 hours, filtered through a pad of Celite® and washed with MeOH (20 mL). The filtrate was concentrated in vacuo and the crude residue was purified by reverse phase preparative HPLC to give ( 3S )-2-(2-cyclopentyl-2-hydroxy-2-phenylacetyl) -N -(( S )-4-hydroxy-3-oxo-1-(( S )-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane - 3-Formamide (minor diastereomer, single diastereomer I), as a white solid (16 mg, 7% yield, observed m/z: 526 [M+H] ⁺ ); ¹ H NMR (400MHz, DMSO-d ₆ ): δ 8.19(d,1H), 7.59(s,1H), 7.46-7.15(m,6H), 5.65(s,1H), 5.06(t,1H ), 4.60-4.42(m,1H), 4.35-3.79(m,4H), 3.26-3.02(m,2H), 2.36-0.86(m,22H).

Step (2b): (3S)-2-(2-cyclopentyl-2-hydroxy-2-phenylacetyl)-N-((S)-4-hydroxy-3-oxo-1-( (S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide (compound 31)

To (3 S ) -N -[(2 S )-4-(benzyloxy)-3-oxo-1-[(3 S )-2-oxopyrrolidin-3-yl]butane- 2-yl]-2-[2-(4-chlorophenyl)-2-cyclopentyl-2-hydroxyacetyl]-2-azabicyclo[2.2.2]octane-3-formamide A stirred solution of (major diastereomer/single diastereomer II, 290 mg, 0.45 mmol) in MeOH (8 mL) was added palladium on carbon catalyst (10% on carbon, 0.3 g, 3 mmol). The reaction mixture was stirred at room temperature under a balloon of hydrogen for 2 hours, filtered through a pad of CELITE® and washed with MeOH (30 mL). The filtrate was concentrated in vacuo and the crude residue was purified by reverse phase preparative HPLC to give ( 3S )-2-(2-cyclopentyl-2-hydroxy-2-phenylacetyl) -N -(( S )-4-hydroxy-3-oxo-1-(( S )-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane - 3-Formamide (major diastereomer/single diastereomer II) as a white solid (25 mg, 11% yield. m/z: 526 [M+H] ⁺ ); ¹ H NMR (400MHz, DMSO-d ₆ ): δ 8.17(d,1H), 7.66(s,1H), 7.49-7.11(m,6H), 5.66(s,1H), 4.58-3.97(m,6H) , 2.36-0.80 (m, 24H).

-2-甲醯胺(化合物32) Example 28: ( S ) -N -(( S )-4-hydroxy-3-oxo-1-(( S )-2-oxopyrrolidin-3-yl)butane-2-yl) -1-(9-Hydroxy-9H-terpine-9-carbonyl)-4-phenylpiperene

-2-formamide (compound 32)

-1,2-二羧酸酯 Step (1): 1-(tert-butyl)2-methyl(S)-4-phenylpiperene

-1,2-dicarboxylate

-1,2-二羧酸酯(5.0g，20.5mmol)和苯基硼酸(5.0g，39.3mmol)在CH₂Cl₂(25mL)中的攪拌溶液加入Cu(OAc)₂(2.2g，12.3mmol)並將反應混合物攪拌24小時。將混合物用H₂O(100mL)和飽和水性鹽水溶液(50mL)洗滌。將合併後的有機萃取物經無水硫酸鈉乾燥並在減壓下濃縮。通過SiO₂管柱層析法(0-10% EtOAc/己烷)純化殘餘物，得到1-(第三丁基)2-甲基(S)-4-苯基哌

-1,2-二羧酸酯(2.5g，產率38%，觀察到m/z：321[M+H]⁺)。 To 1-(tert-butyl)2-methyl( S )-piperene at room temperature

- A stirred solution of 1,2-dicarboxylate (5.0 g, 20.5 mmol) and phenylboronic acid (5.0 g, 39.3 mmol) in CH ₂ Cl ₂ (25 mL) was added to Cu(OAc) ₂ (2.2 g, 12.3 mmol) and the reaction mixture was stirred for 24 hours. The mixture was washed with _H2O (100 mL) and saturated aqueous brine solution (50 mL). The combined organic extracts were dried over anhydrous sodium sulfate and concentrated under reduced pressure. Purification of the residue by _SiO2 column chromatography (0-10% EtOAc/Hexanes) afforded 1-(tert-butyl)2-methyl( S )-4-phenylpiper

- 1,2-dicarboxylate (2.5 g, 38% yield, observed m/z: 321 [M+H] ⁺ ).

-2-羧酸 Step (2) (S)-1-(tert-butoxycarbonyl)-4-phenylpiperene

-2-carboxylic acid

-1,2-二羧酸酯(3.00g，9.34mmol)在THF：水(2：1，25mL)中的攪拌溶液加入LiOH一水化物(1.6g，37.4mmol)並將反應混合物在室溫下攪拌16小時。將混合物在減壓下濃縮以除去有機溶劑。將殘餘物在EtOAc(10mL)和水(10mL)之間分配，並用HCl(1N)將混合物酸化至pH 3。將有機相用鹽水溶液(10mL)洗滌，經無水硫酸鈉乾燥並在減壓下濃縮。用 正戊烷(5mL)研磨殘餘物並通過過濾收集所得固體，得到(S)-1-(第三丁氧基羰基)-4-苯基哌

-2-羧酸(2.2g，產率76%，觀察到m/z：307[M+H]⁺)。 To 1-(tert-butyl)2-methyl( S )-4-phenylpiperene at 0°C

- A stirred solution of 1,2-dicarboxylate (3.00 g, 9.34 mmol) in THF:water (2:1, 25 mL) was added LiOH monohydrate (1.6 g, 37.4 mmol) and the reaction mixture was heated at room temperature Stirring was continued for 16 hours. The mixture was concentrated under reduced pressure to remove the organic solvent. The residue was partitioned between EtOAc (10 mL) and water (10 mL), and the mixture was acidified to pH 3 with HCl (1N). The organic phase was washed with brine solution (10 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was triturated with n-pentane (5 mL) and the resulting solid was collected by filtration to give ( S )-1-(tert-butoxycarbonyl)-4-phenylpiper

-2-Carboxylic acid (2.2 g, 76% yield, observed m/z: 307 [M+H] ⁺ ).

-1-羧酸第三丁酯 Step (3): (S)-2-(((S)-4-chloro-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2- base) carbamoyl) -4-phenylpiperidine

-1-Tertiary butyl carboxylate

-2-羧酸(500mg，1.6mmol)在DMF(5mL)中的攪拌懸浮液加入HATU(937mg，2.5mmol)。在20分鐘之後，加入(S)-3-((S)-2-胺基-4-氯-3-氧代丁基)吡咯啶-2-酮鹽酸鹽(708mg，2.9mmol)在DMF(2mL)中的溶液，隨後逐滴加入N-甲基嗎啉(0.9mL，8.17mmol)。將反應物在0℃下攪拌6小時。用飽和氯化銨水溶液(10mL)稀釋混合物並分離各層。用CH₂Cl₂(2×10mL)萃取水相。用飽和碳酸氫鈉水溶液(10mL)、H₂O(10mL)、鹽水溶液(10mL)洗滌合併後的有機相，用無水硫酸鈉乾燥並在減壓下濃縮。通過正相SiO₂層析法(20-100% EtOAc/己烷)純化殘餘物，得到(S)-2-(((S)-4-氯-3-側氧基-1-((S)-2-氧代吡咯啶-3-基)丁烷-2-基)胺甲醯基)-4-苯基哌

-1-羧酸第三丁酯，為白色固體(240mg，產率30%，觀察到m/z：493[M+H]⁺)。 To ( S )-1-(tert-butoxycarbonyl)-4-phenylpiperene at 0°C

- A stirred suspension of 2-carboxylic acid (500 mg, 1.6 mmol) in DMF (5 mL) was added to HATU (937 mg, 2.5 mmol). After 20 minutes, ( S )-3-(( S )-2-amino-4-chloro-3-oxobutyl)pyrrolidin-2-one hydrochloride (708 mg, 2.9 mmol) in DMF was added (2 mL), followed by the dropwise addition of N -methylmorpholine (0.9 mL, 8.17 mmol). The reaction was stirred at 0 °C for 6 hours. The mixture was diluted with saturated aqueous ammonium chloride (10 mL) and the layers were separated. The aqueous phase was extracted with _CH2Cl2 (2 _x 10 mL). The combined organic phases were washed with saturated aqueous sodium bicarbonate (10 mL), _H2O (10 mL), brine solution (10 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure. Purification of the residue by normal phase _SiO2 chromatography (20-100% EtOAc/hexanes) afforded (S)-2-(((S)-4-chloro-3-oxo-1-((S )-2-oxopyrrolidin-3-yl)butan-2-yl)aminoformyl)-4-phenylpiper

- tert-butyl 1-carboxylate as a white solid (240 mg, 30% yield, observed m/z: 493 [M+H] ⁺ ).

-2-甲醯胺鹽酸鹽 Step (4): (S)-N-((S)-4-chloro-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl )-4-phenylpiperidine

-2-Formamide hydrochloride

-1-羧酸第三丁酯(240mg，0.49mmol)在CH₂Cl₂(2mL)中的攪拌溶液加入HCl(2mL，4M的1,4-二

烷溶液)。將反應混合物在室溫下攪拌12小時，並且然後在減壓下濃縮，得到(S)-N-((S)-4-氯-3-側氧基-1-((S)-2-氧代吡咯啶-3-基)丁烷-2-基)-4-苯基哌

-2-甲醯胺鹽酸鹽，其無需進一步純化即可使用(220mg，觀察到m/z：393[M+H]⁺)。 To (S)-2-(((S)-4-chloro-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)amine Acyl)-4-phenylpiperene

- A stirred solution of tert-butyl 1-carboxylate (240 mg, 0.49 mmol) in CH ₂ Cl ₂ (2 mL) was added with HCl (2 mL, 4M of 1,4-di

alkane solution). The reaction mixture was stirred at room temperature for 12 hours, and then concentrated under reduced pressure to give ( S ) -N -(( S )-4-chloro-3-oxo-1-(( S )-2- Oxypyrrolidin-3-yl)butan-2-yl)-4-phenylpiper

- 2-Formamide hydrochloride which was used without further purification (220 mg, observed m/z: 393 [M+H] ⁺ ).

-2-甲醯胺 Step (5): (S)-N-((S)-4-chloro-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl )-1-(9-Hydroxy-9H-terpine-9-carbonyl)-4-phenylpiperene

-2-Formamide

-2-甲醯胺鹽酸鹽(984mg，2.3mmol)在DMF(2mL)中的溶液，隨後逐滴加入N-甲基嗎啉(0.6mL，5.7mmol)。將反應物在0℃下攪拌3小時。用飽和氯化銨水溶液(10mL)稀釋混合物並分離各層。用CH₂Cl₂(2×20mL)萃取水相。用飽和碳酸氫鈉水溶液(10mL)、H₂O(10mL)、鹽水溶液(10mL)洗滌合併後的有機相，經無水 硫酸鈉乾燥並在減壓下濃縮。通過正相SiO₂層析法(20-100% EtOAc/己烷)純化殘餘物，得到(S)-N-((S)-4-氯-3-側氧基-1-((S)-2-氧代吡咯啶-3-基)丁烷-2-基)-1-(9-羥基-9H-茀-9-羰基)-4-苯基哌

-2-甲醯胺(20mg，產率6%，觀察到m/z：601[M+H]⁺)。 To a stirred suspension of 9-hydroxy-9H-tertilene-9-carboxylic acid (260 mg, 1.1 mmol) in DMF (3 mL) was added HATU (655 mg, 1.7 mmol) at 0°C. After 20 minutes, ( S ) -N -(( S )-4-chloro-3-oxo-1-(( S )-2-oxopyrrolidin-3-yl)butane-2- base)-4-phenylpiperene

- A solution of 2-formamide hydrochloride (984 mg, 2.3 mmol) in DMF (2 mL), followed by dropwise addition of N -methylmorpholine (0.6 mL, 5.7 mmol). The reaction was stirred at 0 °C for 3 hours. The mixture was diluted with saturated aqueous ammonium chloride (10 mL) and the layers were separated. The aqueous phase was extracted with _CH2Cl2 (2 _x 20 mL). The combined organic phases were washed with saturated aqueous sodium bicarbonate (10 mL), _H2O (10 mL), brine solution (10 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure. Purification of the residue by normal phase _SiO2 chromatography (20-100% EtOAc/hexanes) afforded ( S ) -N -(( S )-4-chloro-3-oxo-1-(( S ) -2-Oxopyrrolidin-3-yl)butane-2-yl)-1-(9-hydroxy-9H-fennel-9-carbonyl)-4-phenylpiper

- 2-Formamide (20 mg, yield 6%, observed m/z: 601 [M+H] ⁺ ).

-2-甲醯胺 Step (6): (S)-N-((S)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl )-1-(9-Hydroxy-9H-terpine-9-carbonyl)-4-phenylpiperene

-2-Formamide

-2-甲醯胺(100mg，0.166mmol)和苯甲醯基甲酸(19mg，0.133mmol)在DMF(2mL)中的攪拌溶液加入氟化銫(58mg，0.382mmol)。將反應混合物加熱至60℃，持續4小時。將混合物冷卻至室溫，用EtOAc(60mL)稀釋，用H₂O(3×30mL)、鹽水溶液(30mL)洗滌，經無水硫酸鎂乾燥並在減壓下濃縮。將殘餘物溶解在MeOH(5mL)中，用N₂吹掃並用碳酸鉀(5mg，0.04mmol)處理，伴隨劇烈攪拌1小時。將混合物在減壓下濃縮(水浴溫度保持低於30℃)。通過反相HPLC純化殘餘物，得到(S)-N-((S)-4-羥基-3-側氧基-1-((S)-2-氧代吡咯啶-3-基)丁烷-2-基)-1-(9-羥基-9H-茀-9-羰基)-4-苯基哌

-2-甲醯胺(10mg，產率10%，觀察到m/z：583[M+H]⁺)；¹H NMR(400MHz,DMSO-d₆)：δ 8.56-7.14(m,12H)，6.75-6.26(m,2H)，5.08-3.31(m,7H)，4.28-4.11(m,2H)，3.15-2.67(m,6H)，2.32-1.96(m,3H)，1.75-1.46(m,2H)。 To ( _S ) -N -(( S )-4-chloro-3-oxo- 1 -(( S )-2-oxopyrrolidin-3-yl)butyl Alkyl-2-yl)-1-(9-hydroxy-9H-fluorene-9-carbonyl)-4-phenylpiper

- A stirred solution of 2-formamide (100 mg, 0.166 mmol) and benzoylformic acid (19 mg, 0.133 mmol) in DMF (2 mL) was added cesium fluoride (58 mg, 0.382 mmol). The reaction mixture was heated to 60 °C for 4 hours. The mixture was cooled to room temperature, diluted with EtOAc (60 mL), washed with _H2O (3 x 30 mL), brine solution (30 mL), dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was dissolved in MeOH (5 mL), purged with _N2 and treated with potassium carbonate (5 mg, 0.04 mmol) with vigorous stirring for 1 h. The mixture was concentrated under reduced pressure (water bath temperature kept below 30°C). Purification of the residue by reverse phase HPLC afforded ( S ) -N -(( S )-4-hydroxy-3-oxo-1-(( S )-2-oxopyrrolidin-3-yl)butane -2-yl)-1-(9-hydroxy-9H-fennel-9-carbonyl)-4-phenylpiperene

-2-Formamide (10 mg, yield 10%, observed m/z: 583[M+H] ⁺ ); ¹ H NMR (400MHz, DMSO-d ₆ ): δ 8.56-7.14 (m, 12H) , 6.75-6.26(m,2H), 5.08-3.31(m,7H), 4.28-4.11(m,2H), 3.15-2.67(m,6H), 2.32-1.96(m,3H), 1.75-1.46( m,2H).

Example 29: N -((S)-3-cyclohexyl-1-((( S )-4-hydroxy-3-oxo-1-(( S )-2-oxopyrrolidine-3- Base) butane-2-yl)amino)-1-oxopropan-2-yl)-9-(2,2,2-trifluoroacetamido)-9H-oxo-9-formamide (compound 33)

Step (1): (S)-Methyl 3-cyclohexyl-2-(9H-stilbene-9-formamido)propionate

To 9H-terpinene-9-carboxylic acid (5.0g, 23.8mmol), (S)-2-amino-3-cyclohexylpropionic acid methyl ester hydrochloride (7.9g, 35.6mmol) and PyBOP at 0°C (24.7 g, 47.6 mmol) in DMF (25 mL) was added to a stirred solution of N,N -diisopropylethylamine (21 mL, 120 mmol) and the reaction mixture was stirred at room temperature for 3 hours. The mixture was diluted with ice-cold water (150 mL), and extracted with EtOAc (2 x 200 mL). The combined organic extracts were washed with _H2O (100 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure. Purification of the residue by normal phase _SiO2 chromatography (0-70% EtOAc/hexanes) afforded (S)-methyl 3-cyclohexyl-2-(9H-tertyl-9-carboxamido)propionate (6 g, 66% yield, observed m/z: 378 [M+H] ⁺ ); ¹ H NMR (400 MHz, CDCl ₃ ): δ 7.79 (t, 2H), 7.68 (d, 2H), 7.48- 7.33(m,4H), 5.54(d,1H), 4.81(s,1H), 4.64-4.58(m,1H), 3.63(s,3H), 1.63-1.49(m,5H), 1.45(d, 1H), 1.29-1.22 (m, 1H), 1.07-0.93 (m, 4H), 0.77-0.72 (m, 2H).

Step (2): (S)-Methyl 2-(9-Amino-9H-Oxa-9-formamido)-3-cyclohexylpropionate

Stirring of (S)-methyl 3-cyclohexyl-2-(9H-fluorene-9-formamido)propanoate (1.7 g, 4.5 mmol) in THF (17 mL) at -78 °C over 5 min The solution was added dropwise to n -BuLi (2.5M in hexane, 2.7 mL, 6.75 mmol). The reaction was stirred for 45 minutes. To the above solution was added a solution of O- (diphenylphosphinoyl)hydroxylamine (1.6 g, 6.7 mmol) in THF (10 mL) at -78 °C. The temperature of the reaction mixture was slowly warmed up to room temperature and stirred for 16 hours. The mixture was quenched with saturated aqueous ammonium chloride (50 mL), and extracted with EtOAc (2 x 100 mL). The combined organic extracts were dried over anhydrous sodium sulfate and concentrated under reduced pressure. Purification of the residue by normal phase _SiO2 chromatography (2-100% EtOAc/Hexanes) afforded (S)-2-(9-amino-9H-tertyl-9-carboxamido)-3-cyclo Methyl hexylpropionate (0.6 g, 34% yield, observed m/z: 393 [M+H] ⁺ ); ¹ H NMR (400 MHz, DMSO-d ₆ ): δ 8.35 (d, 1H), 7.78 (d,2H), 7.48-7.72(m,6H), 4.33(m,1H), 3.61(s,3H), 2.85(bs,2H), 1.72-1.52(m,7H), 1.27-1.08(m ,6H).

Step (3): (S)-methyl 3-cyclohexyl-2-(9-(2,2,2-trifluoroacetamido)-9H-trifluoroacetamido)propionate

(S)-2-(9-Amino-9H-tertyl-9-formamido)-3-cyclohexylpropanoic acid methyl ester (600 mg, 1.53 mmol) in CH ₂ Cl ₂ (6 mL ) was added triethylamine (1 mL, 3.05 mmol). The reaction was stirred for 20 min. To the above solution was added trifluoroacetic anhydride (0.31 mL, 2.3 mmol), and the reaction was stirred at room temperature for 2 hours. The reaction was diluted with _H2O (20 mL) and extracted with EtOAc (2 x 50 mL). The combined organic phases were washed with brine solution (30 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure. Purification of the residue by normal phase _SiO2 chromatography (0-70% EtOAc/hexanes) afforded (S)-3-cyclohexyl-2-(9-(2,2,2-trifluoroacetamido )-methyl 9H-Trexa-9-formamido)propionate (400 mg, 53% yield, observed m/z: 489 [M+H] ⁺ ).

Step (4): (S)-3-Cyclohexyl-2-(9-(2,2,2-trifluoroacetamido)-9H-trifluoroacetamido)propanoic acid

To (S)-3-cyclohexyl-2-(9-(2,2,2-trifluoroacetamido)-9H-stilbene-9-formamido)propanoic acid methyl ester (470mg, 0.96mmol ) in THF: _H2O (4:1, 10 mL) was added LiOH monohydrate (200 mg, 4.8 mmol), and the reaction mixture was stirred at room temperature for 2 h. The mixture was concentrated under reduced pressure, then acidified to pH 4 with HCl (1 N), and extracted with EtOAc (2 x 50 mL). The combined organic phases were dried over anhydrous sodium sulfate and concentrated under reduced pressure to obtain ( S )-3-cyclohexyl-2-(9-(2,2,2-trifluoroacetamido)-9H- (420 mg, observed m/z: 475 [M+H] ⁺ ).

Step (5): N-((S)-3-cyclohexyl-1-(((S)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidine-3 -yl)butane-2-yl)amino)-1-oxopropan-2-yl)-9-(2,2,2-trifluoroacetamido)-9H-oxo-9-formyl amine

To ( S )-3-cyclohexyl-2-(9-(2,2,2-trifluoroacetamido)-9H-stilbene-9-formamido)propionic acid (400mg) at 0°C To a stirred solution in DMF (5 mL) was added ( S )-3-(( S )-2-amino-4-hydroxy-3-oxobutyl)pyrrolidin-2-one hydrochloride (375 mg, 1.7 mmol), HATU (384mg, 1.0mmol) and N,N -diisopropylethylamine (0.45mL, 2.5mmol). The mixture was stirred at room temperature for 1 hour. The reaction mixture was diluted with ice-cold water and extracted with EtOAc (2 x 50 mL). The combined organic phases were washed with saturated aqueous brine solution (50 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure. Purification of the residue by reverse phase HPLC gave N -(( S )-3-cyclohexyl-1-((( S )-4-hydroxy-3-oxo-1-((S)-2-oxo Pyrrolidin-3-yl)butan-2-yl)amino)-1-oxopropan-2-yl)-9-(2,2,2-trifluoroacetamido)-9H- 9-Formamide (85 mg, a product derived from (S)-3-cyclohexyl-2-(9-(2,2,2-trifluoroacetamido)-9H-trifluoroacetamido) rate 15%) propionic acid, observed m/z: 643[M+H] ⁺ ); ¹ H NMR (400MHz, DMSO-d ₆ ): δ 10.08 (s, 1H), 8.13 (bs, 1H), 7.88 (t,2H), 7.69-7.62(m,4H), 7.48(t,2H), 7.33(q,2H), 7.19(d,1H), 5.06(t,1H), 4.37-4.32(m,2H ), 4.13-4.04(m,2H), 3.15-3.01(m,2H), 2.16(m,1H), 1.99(m,1H), 1.82(m,1H), 1.62-1.53(m,6H), 1.36(m,3H), 1.00(m,4H), 0.74-0.63(m,2H).

Example 30: (1 S ,3 S ,4 S ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5 , 5-difluoro-2-(9-hydroxy-9H-fen-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide (compound 34)

Step (1): ((S)-1-amino-1-oxo-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)carbamic acid third Butyl ester

To (2S)-2-(tert-butoxycarbonylamino)-3-[(3S)-2-oxopyrrolidin-3-yl]propanoic acid methyl ester (7.0 g, 24.5 mmol ) was added ammonia (7N in MeOH, 56 mL, 392 mmol). The reaction mixture was stirred at room temperature for 64 hours. The mixture was cooled to room temperature and concentrated under reduced pressure to provide N-[(1S)-2-amino-2-oxo-1-[[(3S)-2-oxopyrrolidine-3- tert-butyl]methyl]ethyl]carbamate as a white solid (6.6 g, 99% yield, observed m/z: 272 [M+H] ⁺ ).

Step (2): (S)-2-Amino-3-((S)-2-oxopyrrolidin-3-yl)acrylamide

To N-[(1S)-2-amino-2-oxo-1-[[(3S)-2-oxopyrrolidin-3-yl]methyl]ethyl]carbamate A solution of the ester (3.89 g, 14.3 mmol) in 2-propanol (32 mL) at 0 °C was added dropwise to hydrogen chloride (5.5 M in 2-propanol, 13 mL, 71.7 mmol). The reaction mixture was warmed to 50 °C and stirred for 4 hours, then at room temperature overnight. The mixture was cooled to room temperature and the liquid was decanted. The remaining residue was concentrated under reduced pressure and dried under high vacuum to afford (S) -2-amino-3-(( S )-2-oxopyrrolidin-3-yl)acrylamide Hydrochloride salt as a white solid (2.98 g, 100% yield, observed m/z: 172 [M+H] ⁺ ); ¹ H NMR (400 MHz, methanol- d ₄ ): δ 4.02 (dd, 1H) , 3.43-3.34 (m, 2H), 2.82-2.67 (m, 1H), 2.50-2.37 (m, 1H), 2.13-1.95 (m, 2H), 1.95-1.81 (m, 1H).

Step (3): (1S,3S,4S)-5,5-Difluoro-3-[[(E,1S)-3-fluoro-3-methylsulfonyl-1-[[(3S)- 2-Oxopyrrolidin-3-yl]methyl]allyl]carbamoyl]-2-azabicyclo[2.2.2]octane-2-carboxylic acid tert-butyl ester

To (1 S ,3 S ,4 S )-2-tert-butoxycarbonyl-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxylic acid (80mg, 0.27mmol ) and ( 2S )-2-amino-3-[( 3S )-2-oxopyrrolidin-3-yl]acrylamide hydrochloride (57mg, 0.27mmol) in _CH2Cl2 : _THF To a solution in (1:1, 2 mL) was added HOBt monohydrate (84 mg, 0.55 mmol), EDC hydrochloride (68 mg, 0.36 mmol) and DIPEA (192 μL, 1.10 mmol). The reaction mixture was stirred at room temperature for 2 hours. To the mixture were added _H2O (5 mL) and aqueous brine solution (5 mL). The aqueous phase was extracted with EtOAc (3 x 15 mL). The combined organic phases were dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude residue was purified by normal phase _SiO2 chromatography (0-8% MeOH/ _CH2Cl2 ) to afford (1S,3S,4S)-3-[ _[ (1S)-2-amino-2-end Oxy-1-[[(3S)-2-oxopyrrolidin-3-yl]methyl]ethyl]carbamoyl]-5,5-difluoro-2-azabicyclo[2.2.2 ] tert-butyl octane-2-carboxylate as a white solid (50 mg, 41% yield, observed m/z: 445 [M+H] ⁺ ).

Step (4): (1S,3S,4S)-N-[(1S)-2-Amino-2-oxo-1-[[(3S)-2-oxopyrrolidin-3-yl] Methyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide

烷溶液，1mL)。將反應混合物在室溫下攪拌30min並在減壓下濃縮，得到(1S,3S,4S)-N-[(1S)-2-胺基-2-側氧基-1-[[(3S)-2-氧代吡咯啶-3-基]甲基]乙基]-5,5-二氟-2-氮雜雙環[2.2.2]辛烷-3-甲醯胺的鹽酸鹽，為白色固體(43mg，產率100%，觀察到m/z：345[M+H]⁺)，其無需進一步純化即可用於下一步。 To (1S,3S,4S)-3-[[(1S)-2-amino-2-oxo-1-[[(3S)-2-oxopyrrolidin-3-yl]methyl] Ethyl]carbamoyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-2-carboxylic acid tert-butyl ester (50mg, 0.11mmol) in CH ₂ Cl ₂ (1mL ) solution in hydrochloric acid (4N 1,4-di

alkane solution, 1 mL). The reaction mixture was stirred at room temperature for 30 min and concentrated under reduced pressure to give (1 S ,3 S ,4 S ) -N -[(1 S )-2-amino-2-oxo-1-[ [(3 S )-2-oxopyrrolidin-3-yl]methyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide Hydrochloride salt, as a white solid (43 mg, 100% yield, observed m/z: 345 [M+H] ⁺ ), which was used in the next step without further purification.

Step (5): (1S,3S,4S)-N-((S)-1-amino-1-oxo-3-((S)-2-oxopyrrolidin-3-yl)propane -2-yl)-5,5-difluoro-2-(9-hydroxy-9H-fen-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide

(1 S ,3 S ,4 S ) -N -[(1 S )-2-amino-2-oxo-1-[[(3 S )-2-oxopyrrolidine -3-yl]methyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide hydrochloride (74mg, 0.19mmol) and 9-hydroxy To a solution of terpene-9-carboxylic acid (44 mg, 0.19 mmol) in DMF (2 mL) was added HATU (96 mg, 0.25 mmol) followed by DIEA (84 μL, 0.49 mmol). The reaction mixture was stirred at 0 °C for 10 min, then allowed to warm to room temperature and stirred for an additional 30 min. The mixture was purified by reverse phase HPLC to give ( 1S , 3S , 4S ) -N -[( 1S )-2-amino-2-oxo-1-[[( 3S )-2- Oxypyrrolidin-3-yl]methyl]ethyl]-5,5-difluoro-2-(9-hydroxyl-9-carbonyl)-2-azabicyclo[2.2.2]octane-3 - Formamide as a white foam (55 mg, 51% yield, observed m/z: 553 [M+H] ⁺ ).

Step (6): (1S,3S,4S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-5,5 -Difluoro-2-(9-hydroxy-9H-fen-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide

(1 S ,3 S ,4 S ) -N -[(1 S )-2-amino-2-oxo-1-[[(3 S )-2-oxopyrrolidin-3-yl ]methyl]ethyl]-5,5-difluoro-2-(9-hydroxyl-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide (55mg, 0.10 mmol) and Burgess reagent (48 mg, 0.20 mmol) in _CH2Cl2 (1 mL) was _stirred at room temperature for 2 hours. The reaction mixture was concentrated under reduced pressure and the crude material was purified by reverse phase HPLC to give ( 1S , 3S , 4S ) -N -[( 1S )-1-cyano-2-[( 3S )- 2-Oxopyrrolidin-3-yl]ethyl]-5,5-difluoro-2-(9-hydroxyl-9-carbonyl)-2-azabicyclo[2.2.2]octane-3- Formamide, as a white solid (29 mg, 55% yield, observed m/z: 535[M+H] ⁺ ); ¹ H NMR (400MHz, CDCl ₃ ): δ 7.71-7.64 (m, 2H), 7.55-7.49(m,1H), 7.46-7.37(m,3H), 7.37-7.29(m,2H), 5.92(s,1H), 5.75(s,1H), 4.83(m,1H), 4.53( s,1H), 3.54-3.40(m,2H), 3.15(s,1H), 2.74(m,1H), 2.57-2.34(m,3H), 2.10(m,1H), 2.02-1.89(m, 1H), 1.47-1.6(m, 3H), 1.31(m, 3H).

Example 31: (1 S ,3 S ,4 S )-2-(( R )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( S )-1-cyano Base-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide ( Compound 35)

By adding (1 S ,3 S ,4 S ) -N -[(1S)-2-amino-2-oxo-1-[[(3 S )-2-oxopyrrolidin-3-yl ]methyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide hydrochloride is coupled with an appropriate carboxylic acid to react with respect to ( 1S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-5,5-difluoro-2 -(1 S ,3 S ,4 S )-2-(1 S ,3 S ,4 S )-2- (( R )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidine-3 -yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; observed m/z: 495[M+H] ⁺ ; ¹ H NMR (400MHz, CDCl ₃ ): δ 8.94(s,1H), 7.34(d,2H), 7.31(s,1H), 7.17(d,1H), 6.00(s,1H), 5.26(s,1H), 4.78-4.70(m,1H), 4.54(s,1H), 3.89(s,1H), 3.44(dd,2H), 2.64(s,2H), 2.46(s,1H), 2.40-2.30(m, 1H), 2.13(d, 2H), 1.99(d, 1H), 1.77(d, 3H), 1.05(s, 1H).

Example 32: (1 S ,3 S ,4 S ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl] -2-[2-(3,5-Dichlorophenyl)-2,2-difluoro-acetyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3 - formamide (compound 36)

By adding (1 S ,3 S ,4 S ) -N -[(1S)-2-amino-2-oxo-1-[[(3 S )-2-oxopyrrolidin-3-yl ]methyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide hydrochloride is coupled with an appropriate carboxylic acid to react with respect to ( 1S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-5,5-difluoro-2 -(9-Hydroxyfen-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide was prepared in a similar manner as described for (1 S ,3 S ,4 S ) -N- [(1 S )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[2-(3,5-dichlorophenyl)- 2,2-Difluoro-acetyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; observed m/z: 549 [M+H] ⁺ ; ¹ H NMR (400MHz, CD ₃ OD): δ 7.67(q,1H), 7.59-7.56(m,2H), 5.10-4.99(m,1H), 4.71(m,1H), 4.63(s, 1H), 4.39-4.20(m,1H), 3.77-3.51(m,2H), 2.74-2.58(m,2H), 2.37-2.26(m,1H), 1.97-1.75(m,4H), 1.69- 1.56(m,3H), 1.48(m,1H).

Example 33: (1 S ,3 S ,4 S ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5 ,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide (compound 37)

By adding (1 S ,3 S ,4 S ) -N -[(1S)-2-amino-2-oxo-1-[[(3 S )-2-oxopyrrolidin-3-yl ]methyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide hydrochloride is coupled with an appropriate carboxylic acid to react with respect to ( 1S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-5,5-difluoro-2 -(9-Hydroxyfen-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide was prepared in a similar manner as described for (1 S ,3 S ,4 S ) -N- (( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-(4-methoxy-1H- Indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; observed m/z: 500[M+H] ⁺ ; ¹ H NMR (400MHz, CDCl ₃ ) : δ 9.80(s,1H), 8.61(s,1H), 7.17(s,1H), 6.94(d,2H), 6.49(s,1H), 6.08(s,1H), 5.02(s,1H) , 4.80(d,2H), 3.95(s,3H), 3.25(s,2H), 2.79(s,1H), 2.47(d,2H), 2.24(d,5H), 1.97(d,3H), 1.75(s,2H).

Example 34: (1 S ,3 S ,4 S ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5 ,5-difluoro-2-(2-methyl-1H-indole-7-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide (compound 38)

By adding (1 S ,3 S ,4 S ) -N -[(1S)-2-amino-2-oxo-1-[[(3 S )-2-oxopyrrolidin-3-yl ]methyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide hydrochloride is coupled with an appropriate carboxylic acid to react with respect to ( 1S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-5,5-difluoro-2 -(9-Hydroxyfen-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide was prepared in a similar manner as described for (1 S ,3 S ,4 S ) -N- (( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-(2-methyl-1H-ind Indole-7-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; observed m/z: 484[M+H] ⁺ ; ¹ H NMR (400MHz, CD ₃ OD) : δ 7.52(d,1H), 7.05(dt,2H), 6.20(s,1H), 5.19(dd,1H), 4.90-4.86(m,1H), 4.03(s,1H), 3.30-3.28( m,1H), 2.72-2.61(m,2H), 2.45(s,3H), 2.47-2.06(m,5H), 2.03-1.80(m,4H), 1.80-1.43(m,2H).

Example 35: (1 S ,3 S ,4 S ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5 , 5-difluoro-2-(( R )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-formamide (compound 39)

By adding (1 S ,3 S ,4 S ) -N -[(1S)-2-amino-2-oxo-1-[[(3 S )-2-oxopyrrolidin-3-yl ]methyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide hydrochloride is coupled with an appropriate carboxylic acid to react with respect to ( 1S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-5,5-difluoro-2 -(9-Hydroxyfen-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide was prepared in a similar manner as described for (1 S ,3 S ,4 S ) -N- (( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-(( R )-2-hydroxy- 2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide; observed m/z: 475[M+H] ⁺ ; ¹ H NMR (400MHz, CD ₃ OD ): δ 8.54(s,1H), 7.49(d,2H), 7.36(t,2H), 7.26(t,1H), 5.09(dd,1H), 4.46(s,1H), 4.33(s,1H ), 3.37-3.33(m,2H), 2.79(dd,1H), 2.51-2.27(m,4H), 2.05-1.80(m,3H), 1.62(d,2H), 1.53(s,3H), 1.38(s,1H), 1.28(t,1H).

Example 36: (1 S ,3 S ,4 S ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-2 -(4-(Difluoromethyl)-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide (compound 40)

By adding (1 S ,3 S ,4 S ) -N -[(1S)-2-amino-2-oxo-1-[[(3 S )-2-oxopyrrolidin-3-yl ]methyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide hydrochloride is coupled with an appropriate carboxylic acid to react with respect to ( 1S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-5,5-difluoro-2 -(9-Hydroxyfen-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide was prepared in a similar manner as described for (1 S ,3 S ,4 S ) -N- (( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-2-(4-(difluoromethyl)-1H-indole-2 -carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; observed m/z: 520[M+H] ⁺ ; ¹ H NMR (400MHz, CD ₃ CN): δ 10.61(s,1H), 8.72(s,1H), 7.69(d,1H), 7.38-7.29(m,2H), 7.28-6.88(m,2H), 6.45 (s,1H ), 4.83-4.60(m,3H), 3.36-3.22(m,2H), 2.79-2.74(m,1H), 2.62-2.48(m,1H), 2.47-2.26(m,3H), 2.05-1.68 (m,7H).

Example 37: (1 S ,3 S ,4 S )-N-(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-2 -(4-(Difluoromethyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide (Compound 41)

By adding (1 S ,3 S ,4 S ) -N -[(1S)-2-amino-2-oxo-1-[[(3 S )-2-oxopyrrolidin-3-yl ]methyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide hydrochloride is coupled with an appropriate carboxylic acid to react with respect to ( 1S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-5,5-difluoro-2 (1 S , 3 S , 4 S )-N- (( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-2-(4-(difluoromethyl)-6-fluoro-1H- Indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; observed m/z: 538[M+H] ⁺ ; ¹ H NMR (400MHz, CD ₃ CN): δ 10.69(s,1H), 8.74(s,1H), 7.42(d,1H), 7.29-6.93(m,3H), 6.46(s,1H), 4.85-4.60 (m,3H), 3.39-3.24(m,1H), 2.78-2.74(m,1H), 2.65-2.46(m,1H), 2.44-1.96(m,8H), 1.88-1.65(m,3H) .

Example 38: ( S ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy -1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-formamide (compound 42)

By adding ( S ) -N -(( S )-1-amino-1-oxo-3-(( S )-2-oxopyrrolidin-3-yl)propan-2-yl)-2 -Azabicyclo[2.2.2]octane-3-formamide hydrochloride is coupled with an appropriate carboxylic acid to combine with (1 S ,3 S ,4 S ) -N -[(1 S )-1- Cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-5,5-difluoro-2-(9-hydroxyl-9-carbonyl)-2-aza ( S ) -N -((S)-1-cyano-2-(( S )-2-oxopyrrolidine -3-yl)ethyl)-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; observed m /z: 464[M+H] ⁺ ; ¹ H NMR (400MHz, DMSO-d ₆ ): δ 11.28(s, 1H), 8.66(s, 1H), 7.41(s, 1H), 7.11-7.02(m ,2H), 7.72(s,1H), 6.50(d,1H), 4.95-4.93(m,1H), 4.56(s,1H), 4.50(s,1H), 3.88(s,3H), 3.15- 3.06(m,2H), 2.45-2.32(m,1H), 2.21(s,1H), 2.18-2.05(m,2H), 1.90-1.50(m,10H).

Example 39: (1 S ,3 S ,4 S )-2-(3-Chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-(( S )-1-cyano Base-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide ( Compound 43)

By adding (1 S ,3 S ,4 S ) -N -[(1 S )-2-amino-2-oxo-1-[[(3 S )-2-oxopyrrolidine-3- Base]methyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide hydrochloride is coupled with an appropriate carboxylic acid to react with respect to (1 S , 3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-5,5-difluoro- ( 1S , 3S , 4S )-2 -(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-(( S )-1-cyano-2-(( S )-2-oxopyrrolidine- 3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; observed m/z: 510[M+H] ⁺ ; ¹ H NMR (400MHz, CD ₃ OD): δ 7.26-7.13(m,1H), 6.95-6.74(m,1H), 5.12-5.01(m,1H), 4.90-4.88(m,1H), 4.78-4.53( m,1H), 3.30-3.21(m,2H), 2.77-2.53(m,2H), 2.52-2.16(m,5H), 2.00-1.72(m,5H).

Example 40: (1 R ,2 S ,5 S ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-3 -(9-Hydroxy-9H-fen-9-carbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-formamide (compound 44)

By coupling ( S )-2-amino-3-(( S )-2-oxopyrrolidin-3-yl)propionamide hydrochloride with the appropriate carboxylic )-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-(9-hydroxyl- 9H-Treme-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide was prepared in a similar manner as described for ( 1R , 2S , 5S ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-3-(9-hydroxy-9H-oxo-9-carbonyl)-6,6-di Methyl-3-azabicyclo[3.1.0]hexane-2-carboxamide; observed m/z: 499[M+H] ⁺ ; ¹ H NMR (400MHz, CD ₃ OD): δ 7.79( dd,2H), 7.47(m,2H), 7.37(d,2H), 7.32(d,2H), 5.07(m,1H), 4.30(s,1H), 3.43-3.34(m,2H), 2.75 (m,1H), 2.53(dd,1H), 2.46-2.33(m,2H), 2.31(d,1H), 1.98-1.85(m,2H), 1.17(d,1H), 1.11(dd,1H ), 0.85(s,3H), 0.49(s,3H).

Example 41: (1 S ,3 S ,4 S ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl] -2-[(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-aza Bicyclo[2.2.2]octane-3-carboxamide (Compound 45)

Step (1): N-[(1S)-2-[(1S,3S,4S)-3-[[(1S)-2-Amino-2-oxo-1-[[(3S)- 2-Oxopyrrolidin-3-yl]methyl]ethyl]carbamoyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-2-yl]-1- (Cyclobutylmethyl)-2-oxo-ethyl]carbamate tertiary butyl ester

To (1 S ,3 S ,4 S ) -N -[(1 S )-2-amino-2-oxo-1-[[(3 S )-2-oxopyrrolidin-3-yl ]methyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide hydrochloride (43mg, 0.11mmol) and (2 S )-2- A solution of (tert-butoxycarbonylamino)-3-cyclobutyl-propionic acid (27 mg, 0.11 mmol) in DMF (2 mL) was added with HATU (64 mg, 0.17 mmol) followed by DIPEA (79 μL, 0.45 mmol) ). The reaction mixture was stirred at room temperature for 2 hours. The reaction mixture was diluted with EtOAc (30 mL), washed with 0.5N aqueous hydrochloric acid solution (10 mL) and aqueous brine solution (10 mL). The organic phase was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude residue was purified by normal phase _SiO2 chromatography (0-4% MeOH/ _CH2Cl2 ) to afford N-[(1S)-2-[( _1S ,3S,4S)-3-[[(1S )-2-amino-2-oxo-1-[[(3S)-2-oxopyrrolidin-3-yl]methyl]ethyl]carbamoyl]-5,5-difluoro -Tertiary butyl 2-azabicyclo[2.2.2]oct-2-yl]-1-(cyclobutylmethyl)-2-oxo-ethyl]carbamate as a white solid (29 mg, Yield 45%, observed m/z: 570 [M+H] ⁺ ).

Step (2): (1S,3S,4S)-2-[(2S)-2-Amino-3-cyclobutyl-propionyl]-N-[(1S)-2-Amino-2- Oxy-1-[[(3S)-2-oxopyrrolidin-3-yl]methyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane- 3-Formamide hydrochloride

烷溶液，1mL)。將反應混合物在室溫下攪拌1小時，並在減壓下濃縮，得到(1S,3S,4S)-2-[(2S)-2-胺基-3-環丁基-丙醯基]-N-[(1S)-2-胺基-2-側氧基-1-[[(3S)-2-氧代吡咯啶-3-基]甲基]乙基]-5,5-二氟-2-氮雜雙環[2.2.2]辛烷-3-甲醯胺鹽酸鹽，為白色固體(26mg，產率>100%，觀察到m/z：470[M+H]⁺)，其無需進一步純化即可用於下一步。 To N-[(1S)-2-[(1S,3S,4S)-3-[[(1S)-2-amino-2-oxo-1-[[(3S)-2-oxo Pyrrolidin-3-yl]methyl]ethyl]aminoformyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-2-yl]-1-(cyclobutylmethyl )-tert-butyl 2-oxo-ethyl]carbamate (29 mg, 0.05 mmol) in CH ₂ Cl ₂ (1 mL) was added hydrochloric acid (4N 1,4-di

alkane solution, 1 mL). The reaction mixture was stirred at room temperature for 1 h and concentrated under reduced pressure to give ( 1S , 3S , 4S )-2-[( 2S )-2-amino-3-cyclobutyl-propane Acyl] -N -[(1 S )-2-amino-2-oxo-1-[[(3 S )-2-oxopyrrolidin-3-yl]methyl]ethyl]- 5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide hydrochloride as a white solid (26 mg, yield >100%, observed m/z: 470 [M +H] ⁺ ), which was used in the next step without further purification.

Step (3): (1S,3S,4S)-N-[(1S)-2-Amino-2-oxo-1-[[(3S)-2-oxopyrrolidin-3-yl] Methyl]ethyl]-2-[(2S)-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro -2-Azabicyclo[2.2.2]octane-3-carboxamide

To (1 S ,3 S ,4 S )-2-[(2 S )-2-amino-3-cyclobutyl-propionyl] -N -[(1 S )-2-amino-2 -Oxy-1-[[(3 S )-2-oxopyrrolidin-3-yl]methyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane Alkane-3-carboxamide hydrochloride (26 mg, 0.05 mmol) in MeOH (1 mL) was added ethyl 2,2,2-trifluoroacetate (61 μL, 0.51 mmol) and DIPEA (27 μL, 0.15 mmol) . The reaction mixture was stirred at room temperature for 30 min. Saturated aqueous sodium bicarbonate (10 mL) was added to the reaction mixture and the aqueous phase was extracted with EtOAc (3 x 15 mL). The combined organic phases were dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to give ( 1S , 3S , 4S ) -N -[( 1S )-2-amino-2-oxo Base-1-[[(3S)-2-oxopyrrolidin-3-yl]methyl]ethyl]-2-[( 2S )-3-cyclobutyl-2-[(2,2, 2-Trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide as a white solid (29 mg, yield >100%, observed m/z: 566 [M+H] ⁺ ), which was used in the next step without further purification.

Step (4): (1S,3S,4S)-N-[(1S)-1-cyano-2-[(3S)-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2S)-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2.2 ]octane-3-formamide

To (1 S ,3 S ,4 S ) -N -[(1 S )-2-amino-2-oxo-1-[[(3 S )-2-oxopyrrolidin-3-yl ]methyl]ethyl]-2-[( 2S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5- To a solution of difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide (29 mg, 0.05 mmol) in _CH2Cl2 (1 _mL ) was added Burgess reagent (36 mg, 0.15 mmol). The reaction mixture was stirred at room temperature for 2 hours, and concentrated under reduced pressure. Purification of the crude residue by reverse phase HPLC afforded ( 1S , 3S , 4S ) -N -[( 1S )-1-cyano-2-[( 3S )-2-oxopyrrolidine-3 -yl]ethyl]-2-[(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-di Fluoro-2-azabicyclo[2.2.2]octane-3-carboxamide as a white film (5 mg, 18% yield, observed m/z: 548[M+H] ⁺ ); ¹ H NMR (400MHz, CD ₃ OD): δ 5.05(dd,1H), 4.72(dd,1H), 4.51(dd,1H), 4.38(s,1H), 3.34-3.32(m,1H), 2.74-2.61( m, 1H), 2.59 (s, 1H), 2.53-2.04 (m, 8H), 1.98-1.60 (m, 12H).

Example 42: (1 S ,3 S ,4 S )-N-(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl base)-5,5-difluoro-2-((2,2,2-trifluoroacetyl) -D -leucyl)-2-azabicyclo[2.2.2]octane-3- Formamide (Compound 46)

By adding (1 S ,3 S ,4 S ) -N -[(1 S )-2-amino-2-oxo-1-[[(3 S )-2-oxopyrrolidine-3- Base]methyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide hydrochloride is coupled with an appropriate carboxylic acid to react with respect to (1 S , 3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[(2 S ) -3-Cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide was prepared in a similar manner as described for ( 1S , 3S , 4S )-N-(( S )-1-cyano-2-(( S )-2-oxopyrrolidine- 3-yl)ethyl)-5,5-difluoro-2-((2,2,2-trifluoroacetyl) -D -leucyl)-2-azabicyclo[2.2.2] Octane-3-carboxamide; Observed m/z: 536[M+H] ⁺ ; ¹ H NMR (400MHz, CD ₃ OD): δ 5.18-5.01(m,1H), 4.99-4.89(m, 1H), 4.48-4.43(m,1H), 4.36(s,2H), 3.37-3.32(m,2H), 2.91-2.51(m,3H), 2.45-2.22(m,3H), 2.13(s, 1H), 2.06-1.49 (m, 7H), 1.00-0.83 (m, 6H).

Example 43: (1 S ,3 S ,4 S )-N-(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-2 -(( R )-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2] Octane-3-formamide (Compound 47)

By adding (1 S ,3 S ,4 S ) -N -[(1 S )-2-amino-2-oxo-1-[[(3 S )-2-oxopyrrolidine-3- Base]methyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide hydrochloride is coupled with an appropriate carboxylic acid to react with respect to (1 S , 3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[(2 S ) -3-Cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide was prepared in a similar manner as described for ( 1S , 3S , 4S )-N-(( S )-1-cyano-2-(( S )-2-oxopyrrolidine- 3-yl)ethyl)-2-(( R )-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2 -Azabicyclo[2.2.2]octane-3-carboxamide; observed m/z: 548[M+H] ⁺ ; ¹ H NMR (400MHz, CD ₃ CN): δ 8.00-7.92(m, 2H), 6.19(s,1H), 4.93-4.65(m,3H), 4.36(s 1H), 4.25(s,1H), 3.31-3.11(m,2H), 2.67(s,1H), 2.51- 2.42 (m, 1H), 2.40-2.12 (m, 4H), 2.05-1.94 (m, 2H), 1.94-1.61 (m, 12H).

Example 44: (1 S ,3 S ,4 S )-2-(7-chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 S )-1-cyano- 2-[( 3S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide ( Compound 48)

Step (1): Dimethyl (2S,4S)-2-(tert-butoxycarbonylamino)-4-(2-cyanoethyl)glutarate

To a solution of dimethyl (2S)-2-(tert-butoxycarbonylamino)glutarate (12 g, 44 mmol) in THF (100 mL) was added LiHMDS (1.0 M in THF) dropwise at -78°C solution, 100 mL, 100 mmol). The mixture was stirred at -78°C for 1 hour, and 3-bromopropionitrile (3.9 mL, 47 mmol) was added dropwise. The reaction mixture was stirred at -78°C for 4 hours and quenched with saturated aqueous ammonium chloride (100 mL). The mixture was warmed to room temperature and extracted with EtOAc (3 x 100 mL). The combined organic phases were dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. Purification of the crude residue by normal phase _SiO2 chromatography (20-35% EtOAc/hexanes) afforded (2S,4S)-2-(tert-butoxycarbonylamino)-4-(2-cyanoethyl base) dimethyl glutarate as pale yellow oil (4.9 g, 34% yield, observed m/z: 329 [M+H] ⁺ ).

Step (2): Methyl (2S)-2-(tert-butoxycarbonylamino)-3-[(3S)-2-oxo-3-piperidinyl]propionate

Dimethyl (2S,4S)-2-(tert-butoxycarbonylamino)-4-(2-cyanoethyl)glutarate (3.9 g, 12 mmol) was dissolved in anhydrous MeOH (16 mL) at 0 °C ) was added cobalt(II) chloride hexahydrate (1.7 g, 7.1 mmol). To this mixture was added sodium borohydride (2.7 g, 71 mmol) in portions at 0° C., and the reaction mixture was warmed to room temperature and stirred for 4 hours. To the reaction mixture was added saturated aqueous ammonium chloride (40 mL), and the mixture was concentrated in vacuo to remove MeOH. The aqueous phase was extracted with EtOAc (3 x 60 mL), and the combined organic phases were washed with saturated aqueous ammonium chloride solution (60 mL) and aqueous brine solution (60 mL). The organic phase was dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. The crude residue was purified by normal phase _SiO2 chromatography (0-4% MeOH/ _CH2Cl2 ) to afford (2S)-2-(tert-butoxycarbonylamino)-3 _- [(3S)- Methyl 2-oxo-3-piperidinyl]propionate as a white solid (1.7 g, 49% yield, observed m/z: 301 [M+H] ⁺ ).

Step (3): N-[(1S)-2-amino-2-oxo-1-[[(3S)-2-oxo-3-piperidinyl]methyl]ethyl]amine tertiary butyl carbamate

Add (2S)-2-(tert-butoxycarbonylamino)-3-[(3S)-2-oxo-3-piperidinyl]propanoic acid methyl ester (1.7 g, 5.8 mmol) Ammonia (7N in MeOH, 12 mL, 96 mmol) was added and the reaction mixture was stirred at 70 °C for 40 h. The mixture was cooled to room temperature and concentrated in vacuo. The crude residue was purified by normal phase _SiO2 chromatography (0-8% MeOH/ _CH2Cl2 ) to afford N- _[ (1S)-2-amino-2-oxo-1-[[(3S )-tert-butyl 2-oxo-3-piperidinyl]methyl]ethyl]carbamate as a white solid (1.2 g, yield 70%, observed m/z: 286 [M+ H] ⁺ ).

Step (4): (2S)-2-Amino-3-[(3S)-2-oxo-3-piperidinyl]acrylamide

烷溶液，4mL)。將反應混合物在室溫下攪拌2小時，並在真空中濃縮，得到(2S)-2-胺基-3-[(3S)-2-側氧基-3-哌啶基]丙烯醯胺的鹽酸鹽，為白色固體(0.8g，觀察到m/z：186[M+H]⁺)，其無需進一步純化即可用於下一步。 To the third Butyl ester (1.0g, 3.6mmol) was added with hydrochloric acid (4N 1,4-di

alkane solution, 4 mL). The reaction mixture was stirred at room temperature for 2 hours and concentrated in vacuo to give ( 2S )-2-amino-3-[( 3S )-2-oxo-3-piperidinyl]acryloyl The hydrochloride salt of the amine, as a white solid (0.8 g, observed m/z: 186 [M+H] ⁺ ), was used in the next step without further purification.

Step (5): (1S,3S,4S)-3-[[(1S)-2-Amino-2-oxo-1-[[(3S)-2-oxo-3-piperidine Base]methyl]ethyl]aminoformyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-2-carboxylic acid tert-butyl ester

To (1 S ,3 S ,4 S )-2-tert-butoxycarbonyl-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxylic acid ( 583mg, 2.0mmol) and ( 2S )-2-amino-3-[( 3S )-2-oxo-3-piperidinyl]acrylamide hydrochloride (443mg, 2.0mmol) in CH A solution of ₂ Cl ₂ :THF (1:1, 6 mL) was added HOBt monohydrate (613 mg, 4.0 mmol), followed by EDC hydrochloride (498 mg, 2.6 mmol) and DIPEA (1.4 mL, 8.0 mmol). The reaction mixture was warmed to room temperature and stirred for 2 hours. To the mixture was added _H2O (15 mL) and aqueous brine solution (15 mL). The aqueous phase was extracted with EtOAc (3 x 60 mL). The combined organic phases were dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. The crude residue was purified by normal phase _SiO2 chromatography (0-8% MeOH/ _CH2Cl2 ) to afford (1S,3S,4S)-3-[ _[ (1S)-2-amino-2-end Oxygen-1-[[(3S)-2-oxo-3-piperidinyl]methyl]ethyl]carbamoyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Tert-butyl octane-2-carboxylate as a white solid (620 mg, 68% yield, observed m/z: 459 [M+H] ⁺ ).

Step (6): (1S,3S,4S)-N-[(1S)-2-Amino-2-oxo-1-[[(3S)-2-oxo-3-piperidinyl ]methyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide

烷溶液，4mL)。將反應混合物在室溫下攪拌18小時，並在真空中濃縮，得到(1S,3S,4S)-N-[(1S)-2-胺基-2-側氧基-1-[[(3S)-2-側氧基-3-哌啶基]甲基]乙基]-5,5-二氟-2-氮雜雙環[2.2.2]辛烷-3-甲醯胺的鹽酸鹽，為白色固體(480mg，產率99%，觀察到m/z：359[M+H]⁺)，其無需進一步純化即可用於下一步。 To (1S,3S,4S)-3-[[(1S)-2-amino-2-oxo-1-[[(3S)-2-oxo-3-piperidinyl]methyl ]ethyl]carbamoyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-2-carboxylic acid tert-butyl ester (565 mg, 1.2 mmol) in CH ₂ Cl ₂ ( 2mL) solution in hydrochloric acid (4N 1,4-bis

alkane solution, 4 mL). The reaction mixture was stirred at room temperature for 18 hours and concentrated in vacuo to give ( 1S , 3S , 4S ) -N -[( 1S )-2-amino-2-oxo-1- [[(3 S )-2-oxo-3-piperidinyl]methyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl The hydrochloride salt of the amine, as a white solid (480 mg, 99% yield, observed m/z: 359 [M+H] ⁺ ), was used in the next step without further purification.

Step (7): (1S,3S,4S)-N-[(1S)-2-Amino-2-oxo-1-[[(3S)-2-oxo-3-piperidinyl ]methyl]ethyl]-2-(7-chloro-4-fluoro-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3 - formamide

To (1 S ,3 S ,4 S ) -N -[(1 S )-2-amino-2-oxo-1-[[(3 S )-2-oxo-3-piperidine Base]methyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide hydrochloride (30mg, 0.08mmol) and 7-chloro-4- A solution of fluoro- 1H -indole-2-carboxylic acid (16 mg, 0.08 mmol) in DMF (1 mL) was added HATU (43 mg, 0.11 mmol) followed by DIPEA (53 μL, 0.30 mmol). The reaction mixture was stirred at room temperature for 1 hour. The mixture was diluted with EtOAc (30 mL), washed with 0.5M aqueous hydrochloric acid solution (10 mL) and aqueous brine solution (10 mL). The organic phase was dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. The crude residue was _purified by normal phase _SiO2 chromatography (0-8% MeOH/ _CH2Cl2 ) to afford ( 1S , 3S , 4S ) -N -[( 1S )-2-amino- 2-oxo-1-[[(3 S )-2-oxo-3-piperidinyl]methyl]ethyl]-2-(7-chloro-4-fluoro-1 H -indole -2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide as an off-white solid (27 mg, 64% yield, observed m/z: 554 [M+H] ⁺ ).

Step (8): (1S,3S,4S)-2-(7-chloro-4-fluoro-1H-indole-2-carbonyl)-N-[(1S)-1-cyano-2-[( 3S)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide

To (1 S ,3 S ,4 S ) -N -[(1 S )-2-amino-2-oxo-1-[[(3 S )-2-oxo-3-piperidine Base]methyl]ethyl]-2-(7-chloro-4-fluoro- 1H -indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane - To a solution of 3-formamide (27 mg, 0.05 mmol) in _CH2Cl2 (1 mL) was added Burgess reagent (35 mg, 0.15 _mmol ). The reaction mixture was stirred at room temperature for 1 hour and concentrated in vacuo. Purification of the crude residue by reverse phase HPLC afforded ( 1S , 3S , 4S )-2-(7-chloro-4-fluoro- 1H -indole-2-carbonyl) -N -[( 1S ) -1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane- 3-Formamide as a white solid (10 mg, 39% yield, observed m/z: 536 [M+H]+); ¹ H NMR (400 MHz, CD ₃ OD): δ 7.20 (dd, 1H) , 6.95(s,1H), 6.79(t,1H), 5.22-5.10(m,1H), 4.75(s,1H), 4.66(s,1H), 3.29-3.20(m,2H), 2.70(s ,1H), 2.58-2.35(m,3H), 2.34-2.14(m,2H), 2.10-1.69(m,7H), 1.65-1.50(m,1H).

Example 45: ( 1S , 3S , 4S ) -N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5 , 5-difluoro-2-(9-hydroxy-9H-fen-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide (compound 49)

By adding (1 S ,3 S ,4 S ) -N -[(1 S )-2-amino-2-oxo-1-[[(3 S )-2-oxo-3-piper Pyridyl]methyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide hydrochloride is coupled with an appropriate carboxylic acid to react with respect to (1 S ,3 S ,4 S )-2-(7-chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 S )-1-cyano-2-[(3 S ) -2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide was prepared in a similar manner ( 1 S ,3 S ,4 S )- N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro -2-(9-Hydroxy-9H-fen-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; observed m/z: 549[M+H] ⁺ ; ¹ H NMR (400MHz, CD ₃ OD): δ 7.80(t,2H), 7.56-7.43(m,3H), 7.39(dd,3H), 5.16(dd,1H), 4.53(s,1H), 3.21 (s,1H), 2.61(m,1H), 2.53-2.40(m,2H), 2.14(dd,1H), 1.95(m,3H), 1.70-1.37(m,5H), 1.36-1,10 (m,4H).

Example 46: (1 S ,3 S ,4 S ) -N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5 ,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide (Compound 50)

By adding (1 S ,3 S ,4 S ) -N -[(1 S )-2-amino-2-oxo-1-[[(3 S )-2-oxo-3-piper Pyridyl]methyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide hydrochloride is coupled with an appropriate carboxylic acid to react with respect to (1 S ,3 S ,4 S )-2-(7-chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 S )-1-cyano-2-[(3 S ) -2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide was prepared in a similar manner ( 1 S ,3 S ,4 S )- N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro -2-(4-Methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; observed m/z: 514 [M+H ] ⁺ ; ¹ H NMR (400MHz, CD ₃ OD): δ 7.15(t, 1H), 7.02(d, 1H), 6.85(d, 1H), 6.51(s, 1H), 5.15(d, 1H), 4.9(s,2H), 4.72(s,1H), 3.90(d,3H), 3.26(s,1H), 2.98(s,1H), 2.68(s,1H), 2.57-2.34(m,3H) , 2.26(s,3H), 2.04-1.64(m,6H).

Example 47: (1 S ,3 S ,4 S ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl ]-2-(4,7-difluoro- 1H -indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide (compound 51)

By adding (1 S ,3 S ,4 S ) -N -[(1 S )-2-amino-2-oxo-1-[[(3 S )-2-oxo-3-piper Pyridyl]methyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide hydrochloride is coupled with an appropriate carboxylic acid to react with respect to (1 S ,3 S ,4 S )-2-(7-chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 S )-1-cyano-2-[(3 S ) -2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide was prepared in a similar manner ( 1 S ,3 S ,4 S ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2-( 4,7-Difluoro- 1H -indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; observed m/z: 520[M+H] ⁺ ; ¹ H NMR (400MHz, CD ₃ OD): δ 6.96-6.86 (ddd, 2H), 6.77-6.63 (m, 1H), 5.21-5.10 (m, 1H), 5.10-4.92 (m,1H), 4.80-4.71(d,2H), 3.29-3.05(m,2H), 2.69(s,1H), 2.60-2.37(m,3H), 2.37-2.15(m,2H), 2.10 -2.01(m,1H), 2.01-1.71(m,6H), 1.68-1.48(m,1H), 1.29(s,1H).

Example 48: (1 S ,3 S ,4 S ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl ]-5,5-difluoro-2-(4,6,7-trifluoro-1 H -indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide (Compound 52)

By adding (1 S ,3 S ,4 S ) -N -[(1 S )-2-amino-2-oxo-1-[[(3 S )-2-oxo-3-piper Pyridyl]methyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide hydrochloride is coupled with an appropriate carboxylic acid to react with respect to (1 S ,3 S ,4 S )-2-(7-chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 S )-1-cyano-2-[(3 S ) -2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide was prepared in a similar manner ( 1 S ,3 S ,4 S ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5,5 -Difluoro-2-(4,6,7-trifluoro-1 H -indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; m/ z: 538[M+H] ⁺ ; ¹ H NMR (400MHz, CD ₃ OD): δ 6.95 (s, 1H), 6.90-6.62 (m, 1H), 5.19-4.92 (m, 1H), 4.84-4.66 (m,2H), 3.29-3.19(m,2H), 3.14(s,1H), 2.69(s,1H), 2.60-2.36(m,3H), 2.36-2.17(m,2H), 2.10-2.00 (m, 1H), 1.99-1.71 (m, 7H), 1.69-1.47 (m, 1H).

Example 49: (1 S ,3 S ,4 S )-2-(3-Chloro-4 H -thieno[3,2-b]pyrrole-5-carbonyl) -N -[(1 S )-1 -cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3- Formamide (Compound 53)

By adding (1 S ,3 S ,4 S ) -N -[(1 S )-2-amino-2-oxo-1-[[(3 S )-2-oxo-3-piper Pyridyl]methyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide hydrochloride is coupled with an appropriate carboxylic acid to react with respect to (1 S ,3 S ,4 S )-2-(7-chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 S )-1-cyano-2-[(3 S ) -2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide was prepared in a similar manner ( 1 S ,3 S ,4 S )-2-(3-chloro-4 H -thieno[3,2-b]pyrrole-5-carbonyl) -N -[(1 S )-1-cyano-2 -[( 3S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; Observation to m/z: 524[M+H] ⁺ ; ¹ H NMR (400MHz, CD ₃ OD): δ 7.19(s,1H), 6.89(s,1H), 5.09(s,1H), 4.72(s, 1H), 3.25(s,2H), 2.67(s,1H), 2.60-2.34(m,3H), 2.34-2.14(m,3H), 2.05(s,1H), 1.99-1.67(m,7H) , 1.55(s,1H).

Example 50: (1 S ,3 S ,4 S )-2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N -(( S )-1-cyano-2-( (S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide (compounds 54, 55 and 56)

By adding (1 S ,3 S ,4 S ) -N -[(1 S )-2-amino-2-oxo-1-[[(3 S )-2-oxo-3-piper Pyridyl]methyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide hydrochloride was coupled with an appropriate carboxylic acid ( compound 54 ) to With respect to (1 S ,3 S ,4 S )-2-(7-chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 S )-1-cyano-2 -[( 3S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide as described (1 S ,3 S ,4 S )-2-(2-chloro-9-hydroxy-9H-fennel-9-carbonyl) -N -(( S )-1-cyano-2- ((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide, diastereomeric Mixture of isomers: m/z: 583[M+H] ⁺ ; ¹ H NMR (400MHz, CD ₃ OD): δ 7.79 (q, 2H), 7.53-7.47 (m, 3H), 7.43-7.36 (m,2H), 5.17(m,1H), 4.54(s,1H), 3.21(s,1H), 2.59(s,1H), 2.48(d,2H), 2.13(s,1H), 1.98- 1.78(m,3H), 1.58(d,4H), 1.43-1.18(m,4H), 1.01(s,1H). Separation of the diastereomeric mixture followed by chiral SFC on a CHIRALCEL OJ column using 20% IPA afforded each epimer.

Minor diastereomer (compound 55) : (single diastereomer I, faster eluting diastereomer): (3.8 mg, 25% yield, observed m/z : 583[M+H] ⁺ ). ¹ H NMR (400MHz, CD ₃ OD): δ 7.80(dd,2H), 7.57-7.48(m,3H), 7.45-7.36(m,2H), 5.16(dd,1H), 4.55(d,1H) , 3.2(bs,1H), 2.64-2.57(m,1H), 2.55-2.41(m,2H), 2.34(s,2H), 2.2(m,1H), 2.01-1.78(m,3H), 1.63 (d,3H), 1.38(q,3H), 1.22(s,1H).

Major diastereomer (compound 56) : (single diastereomer II, slower eluting diastereomer): (4.2 mg, 30% yield, observed m/z: 583[M+H] ⁺ ). ¹ H NMR (400MHz, CD ₃ OD): δ 7.78(m,2H), 7.53-7.46(m,3H), 7.40(d,2H), 5.18(m,1H), 4.54(s,1H), 3.22 (s,1H), 2.60(s,1H), 2.55-2.41(m,2H), 2.34(s,2H), 2.15(s,1H), 2.00-1.82(m,3H), 1.63(d,3H ), 1.38(d,2H), 1.23(s,1H), 1.03(s,1H).

Example 51: ( S ) -N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-2-(4-methoxy -1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-formamide (compound 57)

By coupling ( 2S )-2-amino-3-[ ( 3S )-2-oxo-3-piperidinyl]acrylamide hydrochloride with an appropriate carboxylic acid to ,3 S ,4 S )-2-(7-chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 S )-1-cyano-2-[(3 S ) -2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide was prepared in a similar manner ( S ) -N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-2-(4-methoxy-1H-indole -2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; observed m/z: 478[M+H] ⁺ ; ¹ H NMR (400MHz, DMSO-d ₆ ) : δ 11.27(s,1H), 8.66(s,1H), 7.26(s,1H), 7.11-7.03(m,2H), 6.73(s,1H), 6.51(d,1H), 5.05-4.99( m,1H), 4.54(s,1H), 4.45(s,1H), 3.88(s,3H), 3.06(m,2H), 2.24-2.21(m,3H), 2.12(m,1H), 1.86 -1.75(m,4H), 1.72-1.66(m,4H), 1.54-1.50(m,3H), 1.40-1.36(m,1H).

Example 52: (1 S ,3 S ,4 S ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl ]-2-[(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-nitrogen Heterobicyclo[2.2.2]octane-3-carboxamide (Compound 58)

Step (1): N-[(1S)-2-[(1S,3S,4S)-3-[[(1S)-2-Amino-2-oxo-1-[[(3S)- 2-oxo-3-piperidinyl]methyl]ethyl]carbamoyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-2-yl]-1 -(Cyclobutylmethyl)-2-oxo-ethyl]carbamate tertiary butyl ester

To (1 S ,3 S ,4 S ) -N -[(1 S )-2-amino-2-oxo-1-[[(3 S )-2-oxo-3-piperidine Base]methyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide hydrochloride (45mg, 0.11mmol) and (2 S )-2 A solution of -(tert-butoxycarbonylamino)-3-cyclobutyl-propionic acid (28 mg, 0.11 mmol) in DMF (2 mL) was added with HATU (65 mg, 0.17 mmol) and DIPEA (80 μL, 0.46 mmol) . The reaction mixture was stirred at room temperature for 2 hours. The mixture was diluted with EtOAc (30 mL), washed with 0.5M aqueous hydrochloric acid solution (10 mL) and aqueous brine solution (10 mL). The organic phase was dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. The crude residue was purified by normal phase _SiO2 chromatography (0-4% MeOH/ _CH2Cl2 ) to afford N-[(1S)-2-[( _1S ,3S,4S)-3-[[(1S )-2-amino-2-oxo-1-[[(3S)-2-oxo-3-piperidinyl]methyl]ethyl]carbamoyl]-5,5-di Tertiary butyl fluoro-2-azabicyclo[2.2.2]oct-2-yl]-1-(cyclobutylmethyl)-2-oxo-ethyl]carbamate as a colorless oil (50mg , yield 75%, observed m/z: 584 [M+H] ⁺ ).

Step (2): (1S,3S,4S)-2-[(2S)-2-Amino-3-cyclobutyl-propionyl]-N-[(1S)-2-Amino-2- Oxy-1-[[(3S)-2-oxy-3-piperidinyl]methyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide hydrochloride

烷溶液，3mL)。將反應混合物在室溫下攪拌15小時，並在真空中濃縮，得到(1S,3S,4S)-2-[(2S)-2-胺基-3-環丁基-丙醯基]-N-[(1S)-2-胺基-2-側氧基-1-[[(3S)-2-側氧基-3-哌啶基]甲基]乙基]-5,5-二氟-2-氮雜雙環[2.2.2]辛烷-3-甲醯胺鹽酸鹽，為白色固體(45mg，觀察到m/z：484[M+H]⁺)，其無需進一步純化即可用於下一步。 To N-[(1S)-2-[(1S,3S,4S)-3-[[(1S)-2-amino-2-oxo-1-[[(3S)-2-oxo Base-3-piperidinyl]methyl]ethyl]aminoformyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-2-yl]-1-(cyclobutylmethyl Hydrochloric acid ( _4N 1,4 _- di

alkane solution, 3 mL). The reaction mixture was stirred at room temperature for 15 hours and concentrated in vacuo to afford ( 1S , 3S , 4S )-2-[( 2S )-2-amino-3-cyclobutyl-propionyl Base]- N -[(1 S )-2-amino-2-oxo-1-[[(3 S )-2-oxo-3-piperidinyl]methyl]ethyl]- 5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide hydrochloride as a white solid (45 mg, observed m/z: 484 [M+H] ⁺ ), It was used in the next step without further purification.

Step (3): (1S,3S,4S)-N-[(1S)-2-Amino-2-oxo-1-[[(3S)-2-oxo-3-piperidinyl ]methyl]ethyl]-2-[(2S)-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-di Fluoro-2-azabicyclo[2.2.2]octane-3-carboxamide

To (1 S ,3 S ,4 S )-2-[(2 S )-2-amino-3-cyclobutyl-propionyl] -N -[(1 S )-2-amino-2 -Oxy-1-[[(3S)-2-oxy-3-piperidinyl]methyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane Alkane-3-carboxamide hydrochloride (45 mg, 0.09 mmol) in MeOH (1 mL) was added ethyl 2,2,2-trifluoroacetate (103 μL, 0.87 mmol) and DIPEA (45 μL, 0.26 mmol) . The reaction mixture was stirred at room temperature for 30 min. To the mixture was added saturated aqueous sodium bicarbonate (10 mL) and the aqueous phase was extracted with EtOAc (3 x 15 mL). The combined organic phases were dried over anhydrous sodium sulfate, filtered, and concentrated in vacuo to give ( 1S , 3S , 4S ) -N -[( 1S )-2-amino-2-oxo -1-[[(3 S )-2-oxo-3-piperidinyl]methyl]ethyl]-2-[(2 S )-3-cyclobutyl-2-[(2,2 ,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide as a colorless oil (50 mg, yield Yield 100%, observed m/z: 580 [M+H] ⁺ ), which was used in the next step without further purification.

Step (4): (1S,3S,4S)-N-[(1S)-1-cyano-2-[(3S)-2-oxo-3-piperidinyl]ethyl]-2- [(2S)-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide

To (1 S ,3 S ,4 S ) -N -[(1 S )-2-amino-2-oxo-1-[[(3 S )-2-oxo-3-piperidine base]methyl]ethyl]-2-[( 2S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5 - To a solution of difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide (50 mg, 0.09 mmol) in _CH2Cl2 (1 _mL ) was added Burgess reagent (62 mg, 0.26 mmol). The reaction mixture was stirred at room temperature for 1 hour and concentrated in vacuo. Purification of the crude residue by reverse phase HPLC afforded ( 1S , 3S , 4S ) -N -[( 1S )-1-cyano-2-[( 3S )-2-oxo-3- Piperidinyl]ethyl]-2-[(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5- Difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide as a white solid (14 mg, 28% yield, observed m/z: 562[M+H] ⁺ ); ¹ H NMR (400MHz, CD ₃ OD): δ 5.10(dd,1H), 4.72(dd,1H), 4.52-4.47(m,1H), 4.38(s,1H), 3.29-3.16(m,2H), 2.59 (s, 1H), 2.56-2.36 (m, 4H), 2.30-1.99 (m, 7H), 1.97-1.63 (m, 10H), 1.58-1.47 (m, 1H).

Example 53: (1 S ,3 S ,4 S ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl ]-5,5-difluoro-2-[(2 S )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]- 2-Azabicyclo[2.2.2]octane-3-carboxamide (compound 59)

By adding (1 S ,3 S ,4 S ) -N -[(1 S )-2-amino-2-oxo-1-[[(3 S )-2-oxo-3-piper Pyridyl]methyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide hydrochloride is coupled with an appropriate carboxylic acid to react with respect to (1 S ,3 S ,4 S ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2-[(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2.2] (1 S ,3 S ,4 S ) -N -[(1 S )-1-cyano-2-[(3 S )-2-side Oxy-3-piperidinyl]ethyl]-5,5-difluoro-2-[(2 S )-4-methyl-2-[(2,2,2-trifluoroacetyl)amine Base]pentyl]-2-azabicyclo[2.2.2]octane-3-carboxamide; observed m/z: 550[M+H] ⁺ ; ¹ H NMR (400MHz, CD ₃ OD) : δ 5.20-5.06(m,1H), 4.97-4.89(m,1H), 4.52-4.40(m,1H), 4.37-4.28(m,1H), 3.29-3.21(m,2H), 2.59(s ,1H), 2.55-2.20(m,4H), 2.16-1.43(m,13H), 0.96(d,4H), 0.92(d,1H), 0.83(d,1H).

Example 54: (1 S ,3 S ,4 S ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl ]-5,5-difluoro-2-[(2R)-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo [2.2.2] Octane-3-formamide (Compound 60)

By adding (1 S ,3 S ,4 S ) -N -[(1 S )-2-amino-2-oxo-1-[[(3 S )-2-oxo-3-piper Pyridyl]methyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide hydrochloride is coupled with an appropriate carboxylic acid to react with respect to (1 S ,3 S ,4 S ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2-[(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2.2] (1 S ,3 S ,4 S ) -N -[(1 S )-1-cyano-2-[(3 S )-2-side Oxy-3-piperidinyl]ethyl]-5,5-difluoro-2-[(2R)-4-methyl-2-[(2,2,2-trifluoroacetyl)amino ]pentyl]-2-azabicyclo[2.2.2]octane-3-carboxamide; observed m/z: 550[M+H] ⁺ ; ¹ H NMR (400MHz, CD ₃ OD)δ : 5.09(dd,1H), 4.85(dd,1H), 4.51(s,1H), 4.41(s,1H), 3.29-3.20(m,2H), 2.59(d,1H), 2.55-2.37(m ,3H), 2.32-1.45(m,13H), 0.97(dd,6H).

Example 55: (1 S ,3 S ,4 S ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl ]-2-[(2 S )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-nitrogen Heterobicyclo[2.2.2]octane-3-carboxamide (Compound 61)

By adding (1 S ,3 S ,4 S ) -N -[(1 S )-2-amino-2-oxo-1-[[(3 S )-2-oxo-3-piper Pyridyl]methyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide hydrochloride is coupled with an appropriate carboxylic acid to react with respect to (1 S ,3 S ,4 S ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2-[(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2.2] (1 S ,3 S ,4 S ) -N -[(1 S )-1-cyano-2-[(3 S )-2-side Oxy-3-piperidinyl]ethyl]-2-[(2 S )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl] -5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; observed m/z: 548[M+H] ⁺ ; ¹ H NMR (400MHz, CD ₃ OD ): δ 5.09(dd,1H), 4.58-4.49(m,2H), 3.29-3.20(m,2H), 2.63-2.37(m,4H), 2.32-1.69(m,12H), 1.57-1.36( m, 2H), 1.00-0.84(m, 1H), 0.60-0.43(m, 2H), 0.27-0.07(m, 1H).

Example 56: (1 S ,3 S ,4 S ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl ]-2-[(2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-nitrogen Heterobicyclo[2.2.2]octane-3-carboxamide (Compound 62)

By adding (1 S ,3 S ,4 S ) -N -[(1 S )-2-amino-2-oxo-1-[[(3 S )-2-oxo-3-piper Pyridyl]methyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide hydrochloride is coupled with an appropriate carboxylic acid to react with respect to (1 S ,3 S ,4 S ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2-[(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2.2] (1 S ,3 S ,4 S ) -N -[(1 S )-1-cyano-2-[(3 S )-2-side Oxy-3-piperidinyl]ethyl]-2-[(2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl] -5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; observed m/z: 562[M+H] ⁺ ; ¹ H NMR (400MHz, CD ₃ OD ): δ 5.12(dd,1H), 4.80(dd,1H), 4.49-4.42(m,1H), 4.32(s,1H), 3.29-3.20(m,2H), 2.63-1.45(m,23H) .

Example 57: (1 S ,3 S ,4 S ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl ]-2-[(2R)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-aza Bicyclo[2.2.2]octane-3-carboxamide (Compound 63)

By adding (1 S ,3 S ,4 S ) -N -[(1 S )-2-amino-2-oxo-1-[[(3 S )-2-oxo-3-piper Pyridyl]methyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide hydrochloride is coupled with an appropriate carboxylic acid to react with respect to (1 S ,3 S ,4 S ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2-[(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2.2] (1 S ,3 S ,4 S ) -N -[(1 S )-1-cyano-2-[(3 S )-2-side Oxy-3-piperidinyl]ethyl]-2-[(2R)-3,3-dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]- 5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; observed m/z: 550[M+H] ⁺ ; ¹ H NMR (400MHz, CD ₃ OD) : δ 5.17-5.03(m,1H), 4.47(d,2H), 3.29-3.23(m,2H), 2.61-2.18(m,5H), 2.12-1.68(m,8H), 1.60-1.48(m ,1H), 1.02(d,10H).

Example 58: ( 1S , 3S , 4S ) -N -[( 1S )-1-cyano-2-[(3S)-2-oxo-3-piperidinyl]ethyl] -2-[(2 S )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide (Compound 64)

Step (1): (2S)-2-(2,5-difluoroaniline)propionic acid

To a solution of ( 2S )-2-aminopropionic acid (89 mg, 1.00 mmol) and 2-bromo-1,4-difluoro-benzene (0.06 mL, 0.50 mmol) in DMSO (3 mL) was added potassium phosphate ( 212mg, 1.00mmol) and copper iodide (19mg, 0.10mmol). The reaction mixture was purged with nitrogen for 5 min and stirred at 100 °C for 3 h in a microwave reactor. Filtration of the mixture through CELITE® and purification by reverse phase HPLC afforded ( 2S )-2-(2,5-difluoroaniline)propionic acid as a white solid (42 mg, 42% yield, observed m/z: 202 [M+H] ⁺ ).

Step (2): (1S,3S,4S)-N-[(1S)-2-Amino-2-oxo-1-[[(3S)-2-oxo-3-piperidinyl ]methyl]ethyl]-2-[(2S)-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide

To (1 S ,3 S ,4 S ) -N -[(1 S )-2-amino-2-oxo-1-[[(3 S )-2-oxo-3-piperidine Base]methyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide hydrochloride (30mg, 0.08mmol) and (2 S )-2 -(2,5-Difluoroaniline)propionic acid (15 mg, 0.08 _mmol ) in _CH2Cl2 :THF (1:1, 2 mL) was added HOBt monohydrate (23 mg, 0.15 mmol) followed by EDC Hydrochloride (19 mg, 0.10 mmol) and DIPEA (53 μL, 0.30 mmol). The reaction mixture was stirred at room temperature for 1 hour. To the mixture was added _H2O (10 mL) and the aqueous phase was extracted with EtOAc (2 x 30 mL). The combined organic phases were dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. The crude residue was _purified by normal phase _SiO2 chromatography (0-10% MeOH/ _CH2Cl2 ) to afford ( 1S , 3S , 4S ) -N -[( 1S )-2-amino- 2-oxo-1-[[(3 S )-2-oxo-3-piperidinyl]methyl]ethyl]-2-[(2 S )-2-(2,5-di Fluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide as a white solid (24 mg, 58% yield, observed m/z : 542[M+H] ⁺ ).

Step (3): (1S,3S,4S)-N-[(1S)-1-cyano-2-[(3S)-2-oxo-3-piperidinyl]ethyl]-2- [(2S)-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide

To (1 S ,3 S ,4 S ) -N -[(1 S )-2-amino-2-oxo-1-[[(3 S )-2-oxo-3-piperidine Base] methyl] ethyl] -2-[(2S)-2-(2,5-difluoroaniline) propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane To a solution _of alkane-3-carboxamide (24 mg, 0.04 mmol) in anhydrous _CH2Cl2 (1 mL) was added Burgess reagent (32 mg, 0.13 mmol). The reaction mixture was stirred at room temperature for 2 hours and concentrated in vacuo. Purification of the crude residue by reverse phase HPLC afforded ( 1S , 3S , 4S ) -N -[( 1S )-1-cyano-2-[( 3S )-2-oxo-3- Piperidinyl]ethyl]-2-[(2 S )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane Alkane-3-carboxamide as a white solid (0.8 mg, 3% yield, observed m/z: 524 [M+H] ⁺ ); ¹ H NMR (400 MHz, CD ₃ OD): δ 7.00-6.85 (m,1H), 6.57-6.42(m,1H), 6.39-6.20(m,1H), 5.09(dd,1H), 4.59-4.44(m,2H), 3.29-3.21(m,1H), 2.63 -1.70(m,12H), 1.59-1.35(m,4H), 1.29(s,3H).

Example 59: (1 S ,3 S ,4 S )-2-[(2 R )-2-(3-chloro-2-methyl-aniline)propionyl] -N -[(1 S )- 1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3 - formamide (compound 65)

By adding (1 S ,3 S ,4 S ) -N -[(1 S )-2-amino-2-oxo-1-[[(3 S )-2-oxo-3-piper Pyridyl]methyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide hydrochloride is coupled with an appropriate carboxylic acid to react with about 1S , 3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2-[(2 S )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide (1 S ,3 S ,4 S )-2-[(2 R )-2-(3-chloro-2-methyl-aniline)propionyl] -N -[(1 S )-1-cyano -2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide ; Observed m/z: 536 [M+H] ⁺ ; ¹ H NMR (400 MHz, CD ₃ OD): δ 7.00 (t, 1H), 6.71 (d, 1H), 6.51 (d, 1H), 5.16- 4.97 (m, 1H), 4.67-4.34 (m, 2H), 3.26-3.05 (m, 2H), 2.64-2.11 (m, 6H), 1.84 (d, 3H), 1.62-0.82 (m, 12H).

Example 60: (1 S ,3 S ,4 S )-2-[(2 R )-2-(3-chloroanilino)-4-methyl-pentyl] -N -[(1 S ) -1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane- 3-Formamide (Compound 66)

Step (1): (1S,3S,4S)-3-(((S)-1-amino-1-oxo-3-((S)-2-oxopiperidin-3-yl) Propan-2-yl)carbamoyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-2-carboxylic acid tert-butyl ester

To (1 S ,3 S ,4 S )-2-tert-butoxycarbonyl-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxylic acid (80mg, 0.27mmol ) and ( 2S )-2-amino-3-[( 3S )-2-oxopiperidin-3-yl]acrylamide hydrochloride (57mg, 0.27mmol) in _CH2Cl2 : _THF To a solution in (1:1, 2 mL) was added HOBt monohydrate (84 mg, 0.55 mmol), EDC hydrochloride (69 mg, 0.36 mmol) and DIPEA (192 μL, 1.1 mmol). The reaction mixture was stirred at room temperature for 2 hours. To the mixture were added _H2O (5 mL) and aqueous brine solution (5 mL). The aqueous phase was extracted with EtOAc (3 x 15 mL). The combined organic phases were dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude residue was _purified by normal phase _SiO2 chromatography (0-8% MeOH/ _CH2Cl2 ) to afford (1S,3S,4S)-3-(((S)-1-amino-1-end Oxy-3-((S)-2-oxopiperidin-3-yl)propan-2-yl)carbamoyl)-5,5-difluoro-2-azabicyclo[2.2.2] Tert-butyl octane-2-carboxylate as a white solid (50 mg, 41% yield, observed m/z: 445 [M+H] ⁺ ).

Step (2): (1S,3S,4S)-3-[[(1S)-2-Amino-2-oxo-1-[[(3S)-2-oxo-3-piperidine Base]methyl]ethyl]aminoformyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-2-carboxylic acid tert-butyl ester

To (1S,3S,4S)-3-[[(1S)-2-amino-2-oxo-1-[[(3S)-2-oxo-3-piperidinyl]methyl ]ethyl]carbamoyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-2-carboxylic acid tert-butyl ester (395 mg, 0.86 mmol) in anhydrous CH ₂ Cl ₂ To the solution in (3 mL) was added Burgess reagent (411 mg, 1.7 mmol). The reaction mixture was stirred at room temperature for 3 hours and quenched with _H2O (10 mL). The aqueous phase was extracted with EtOAc (3 x 15 mL). The combined organic phases were dried over anhydrous sodium sulfate, filtered and concentrated under vacuum. The crude residue was purified by normal phase SiO ₂ column chromatography (0-8% MeOH/CH ₂ Cl ₂ ) to afford (1S,3S,4S)-3-[[(1S)-1-cyano-2 -[(3S)-2-oxo-3-piperidinyl]ethyl]aminoformyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-2-carboxy tert-Butyl acid as a white solid (340 mg, 90% yield, observed m/z: 441 [M+H] ⁺ ).

Step (3): (1S,3S,4S)-N-[(1S)-1-cyano-2-[(3S)-2-oxo-3-piperidinyl]B Base]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide

To (1S,3S,4S)-3-[[(1S)-1-cyano-2-[(3S)-2-oxo-3-piperidinyl]ethyl]carbamoyl]- A solution of tert-butyl 5,5-difluoro-2-azabicyclo[2.2.2]octane-2-carboxylate (60 mg, 0.14 mmol) in EtOH (5 mL) was added to p-toluenesulfonic acid monohydrate (29 mg, 0.15 mmol). The reaction mixture was stirred at 80 °C for 1.5 hours and concentrated in vacuo to afford the title compound ( 1S , 3S , 4S ) -N -[( 1S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide p-toluenesulfonate , as a colorless oil (70 mg, >100% yield, observed m/z: 341 [M+H] ⁺ ), which was used in the next step without further purification.

Step (4): (2R)-2-[(5-Chloro-3-pyridyl)amino]propionic acid

To a solution of ( 2R )-2-amino-4-methyl-pentanoic acid (262 mg, 2.0 mmol) and 1-bromo-3-chloro-benzene (118 μL, 1.0 mmol) in DMSO (3 mL) was added phosphoric acid Tripotassium (425 mg, 2.0 mmol) and copper iodide (38 mg, 0.2 mmol). The reaction mixture was purged with nitrogen for 5 min and stirred at 100 °C for 3 h. The reaction mixture was filtered and purified by reverse phase HPLC to afford ( 2R )-2-(3-chloroanilino)-4-methyl-pentanoic acid as a yellow solid (68 mg, 28% yield, observed m/ z: 242[M+H] ⁺ ).

Step (5): (1S,3S,4S)-2-[(2R)-2-(3-Chloroanilino)-4-methyl-pentyl]-N-[(1S)-1-cyano Base-2-[(3S)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide

To (2 R )-2-(3-chloroanilino)-4-methyl-pentanoic acid (17 mg, 0.07 mmol) and (1 S ,3 S ,4 S ) -N -[(1 S )-1 -cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3- A solution of formamide 4-tosylate (35 mg, 0.07 mmol) in DMF (0.5 mL) was added dropwise to a solution of DIPEA (48 μL, 0.27 mmol) and HATU (31 mg, 0.08 mmol) in DMF (0.5 mL) solution. The reaction mixture was stirred at room temperature for 30 min and purified by reverse phase preparative HPLC to give ( 1S , 3S , 4S )-2-[( 2R )-2-(3-chloroanilino)-4- Methyl-pentyl] -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5,5-di Fluoro-2-azabicyclo[2.2.2]octane-3-carboxamide as a white solid (8 mg, 21% yield, observed m/z: 564[M+H] ⁺ ); ¹ H NMR (400MHz, CD ₃ OD): δ 7.13-7.00(m,1H), 6.71-6.44(m,3H), 5.13-5.01(m,1H), 4.62(s,1H), 4.43(d,1H), 4.37-4.07(m,1H), 3.25-3.09(m,2H), 2.56-2.38(m,3H), 2.30-2.09(m,3H), 1.96-1.50(m,10H), 1.45-1.33(m ,1H), 1.05-0.93 (m,6H).

Example 61: (1 S ,3 S ,4 S )-2-[(2 R )-2-(3-chloroanilino)-3-cyclopropyl-propionyl] -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-formamide (compound 67)

By adding (1 S ,3 S ,4 S ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]- 5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamide 4-toluenesulfonate was coupled with an appropriate carboxylic acid to react with respect to ( 1S , 3S , 4S ) -2-[(2 R )-2-(3-chloroanilino)-4-methyl-pentyl] -N -[(1 S )-1-cyano-2-[(3 S )- 2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide was prepared in an analogous manner (1 S ,3 S ,4 S )-2-[(2 R )-2-(3-chloroanilino)-3-cyclopropyl-propionyl] -N -[(1 S )-1-cyano -2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide ; Observed m/z: 562[M+H] ⁺ ; ¹ H NMR (400MHz, CD ₃ OD): δ 7.13-7.00 (m, 1H), 6.71-6.44 (m, 3H), 5.13-5.01 (m ,1H), 4.62(s,1H), 4.43(d,1H), 4.37-4.07(m,1H), 3.25-3.09(m,2H), 2.56-2.38(m,2H), 2.30-2.09(m ,2H), 1.96-1.50(m,10H), 1.45-1.33(m,1H), 1.05-0.93(m,6H).

Example 62: (1 S ,3 S ,4 S ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl ]-2-[(2 R )-3-cyclopropyl-2-[(5-methyl-3-pyridyl)amino]propionyl]-5,5-difluoro-2-azabicyclo [2.2.2] Octane-3-formamide (Compound 68)

By adding (1 S ,3 S ,4 S ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]- 5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamide 4-toluenesulfonate was coupled with an appropriate carboxylic acid to react with respect to ( 1S , 3S , 4S ) -2-[(2 R )-2-(3-chloroanilino)-4-methyl-pentyl] -N -[(1 S )-1-cyano-2-[(3 S )- 2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide was prepared in an analogous manner (1 S ,3 S ,4 S ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2-[( 2 R )-3-cyclopropyl-2-[(5-methyl-3-pyridyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane Alkane-3-carboxamide; Observed m/z: 543[M+H] ⁺ ; ¹ H NMR (400MHz, CD ₃ OD): δ 7.87-7.75 (m, 1H), 7.66 (d, 1H), 7.02-6.90(m,1H), 5.22-5.00(m,1H), 4.61(s,1H), 4.54-4.36(m,2H), 3.24-3.08(m,2H), 2.55(s,1H), 2.50-2.37(m,2H), 2.34-2.17(m,6H), 1.98-1.21(m,10H), 0.96-0.81(m,1H), 0.56-0.45(m,2H), 0.25-0.01(m ,2H).

Example 63: (1 S ,3 S ,4 S ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl ]-2-[(2 R )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl Amine (Compound 69)

By adding (1 S ,3 S ,4 S ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]- 5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamide 4-toluenesulfonate was coupled with an appropriate carboxylic acid to react with respect to ( 1S , 3S , 4S ) -2-[(2 R )-2-(3-chloroanilino)-4-methyl-pentyl] -N -[(1 S )-1-cyano-2-[(3 S )- 2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide was prepared in an analogous manner (1 S ,3 S ,4 S ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2-[( 2 R )-2-(2,5-difluoroaniline) propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; m/ z: 524[M+H] ⁺ ; ¹ H NMR (400MHz, CD ₃ OD): δ 7.02-6.78 (m, 1H), 6.61-6.41 (m, 1H), 6.36-6.24 (m, 1H), 5.21 -5.00(m,1H), 4.63-4.39(m,3H), 3.23-3.12(m,2H), 2.60-1.04(m,17H).

Example 64: (1 S ,3 S ,4 S )-2-[(2 R )-2-[(5-chloro-3-pyridyl)amino]propionyl] -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-formamide (compound 70)

By adding (1 S ,3 S ,4 S ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]- 5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamide 4-toluenesulfonate was coupled with an appropriate carboxylic acid to react with respect to ( 1S , 3S , 4S ) -2-[(2 R )-2-(3-chloroanilino)-4-methyl-pentyl] -N -[(1 S )-1-cyano-2-[(3 S )- 2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide was prepared in an analogous manner (1 S ,3 S ,4 S )-2-[(2 R )-2-[(5-chloro-3-pyridyl)amino]propionyl] -N -[(1 S )-1-cyano -2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide ; Observed m/z: 523 [M+H] ⁺ ; ¹ H NMR (400MHz, CD ₃ OD): δ 8.09 (d, 1H), 7.91 (d, 1H), 7.65-7.58 (m, 1H), 5.12-5.00(m,1H), 4.62-4.45(m,3H), 3.23-3.12(m,2H), 2.61(s,1H), 2.55-2.18(m,5H), 1.97-1.73(m,5H ), 1.65-1.30(m,6H).

Example 65: (1 S ,3 S ,4 S )-2-[(2 R )-2-(3-chloroanilino)propionyl] -N -[(1 S )-1-cyano- 2-[( 3S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide ( Compound 71)

By adding (1 S ,3 S ,4 S ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]- 5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamide 4-toluenesulfonate was coupled with an appropriate carboxylic acid to react with respect to ( 1S , 3S , 4S ) -2-[(2 R )-2-(3-chloroanilino)-4-methyl-pentyl] -N -[(1 S )-1-cyano-2-[(3 S )- 2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide was prepared in a similar manner (1 S ,3 S ,4 S )-2-[(2 R )-2-(3-chloroanilino)propionyl] -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; observed m/z: 522[M+H]+; 1H NMR (400MHz, CD ₃ OD): δ 7.10(t,1H), 6.73-6.64(m,2H), 6.61-6.55(m,1H), 5.14-5.03(m, 1H), 4.57-4.43(m,2H), 4.38(q,1H), 3.21-3.11(m,2H), 2.61-2.37(m,3H), 2.35-2.13(m,3H), 1.94-1.71( m, 5H), 1.65-1.48 (m, 2H), 1.46-1.29 (m, 4H).

Example 66: (1 S ,3 S ,4 S ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl ]-2-[(2 R )-3-cyclopropyl-2-[(1-methylpyrazolyl-4-yl)amino]propionyl]-5,5-difluoro-2-nitrogen Heterobicyclo[2.2.2]octane-3-carboxamide (compound 72)

By adding (1 S ,3 S ,4 S ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]- 5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamide 4-toluenesulfonate was coupled with an appropriate carboxylic acid to react with respect to ( 1S , 3S , 4S ) -2-[(2 R )-2-(3-chloroanilino)-4-methyl-pentyl] -N -[(1 S )-1-cyano-2-[(3 S )- 2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide was prepared in an analogous manner (1 S ,3 S ,4 S ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2-[( 2 R )-3-cyclopropyl-2-[(1-methylpyrazolyl-4-yl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2.2 ]octane-3-carboxamide; Observed m/z: 532[M+H] ⁺ ; ¹ H NMR (400MHz, CD ₃ OD): δ 7.23(d,1H), 7.16(d,1H), 5.12(dd,1H), 4.58(s,1H), 4.47(d,1H), 4.05(t,1H), 3.79(s,3H), 3.25-3.16(m,2H), 2.60-1.19(m, 14H), 0.96-0.74 (m, 3H), 0.52-0.45 (m, 2H), 0.17-0.09 (m, 2H).

Example 67: ( 1S , 3S , 4S )-2-[2-(3-Chloro-2-methyl-aniline)acetyl] -N -[( 1S )-1-cyano- 2-[( 3S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide ( Compound 73)

By adding (1 S ,3 S ,4 S ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]- 5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamide 4-toluenesulfonate was coupled with an appropriate carboxylic acid to react with respect to ( 1S , 3S , 4S ) -2-[(2 R )-2-(3-chloroanilino)-4-methyl-pentyl] -N -[(1 S )-1-cyano-2-[(3 S )- 2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide was prepared in an analogous manner (1 S ,3 S ,4 S )-2-[2-(3-Chloro-2-methyl-aniline)acetyl] -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; observed m/z: 522[M+H] ⁺ ; ¹ H NMR (400MHz, CD ₃ OD): δ 7.09-6.93 (m, 1H), 6.79-6.65 (m, 1H), 6.58-6.45 (m, 1H), 5.18-5.02 (m,1H), 4.60-4.49(m,1H), 4.38(d,1H), 4.09(d,2H), 3.27-3.19(m,2H), 2.62(s,1H), 2.52-1.40(m ,16H).

Example 68: (1 S ,3 S ,4 S )-2-[1-(3-Chloroanilino)cyclopropanecarbonyl] -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide (compound 74)

By adding (1 S ,3 S ,4 S ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]- 5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamide 4-toluenesulfonate was coupled with an appropriate carboxylic acid to react with respect to ( 1S , 3S , 4S ) -2-[(2 R )-2-(3-chloroanilino)-4-methyl-pentyl] -N -[(1 S )-1-cyano-2-[(3 S )- 2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide was prepared in an analogous manner (1 S ,3 S ,4 S )-2-[1-(3-chloroanilino)cyclopropanecarbonyl] -N -[(1 S )-1-cyano-2-[(3 S )-2-side Oxy-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; observed m/z: 534 [M+H ] ⁺ ; ¹ H NMR (400MHz, CD ₃ OD): δ 7.04(t,1H), 6.72(t,1H), 6.63-6.59(m,2H), 5.08(dd,1H), 4.89-4.83(m ,1H), 4.39-4.34(m,1H), 3.35-3.34(m,2H), 3.30-3.25(m,1H), 2.59-2.37(m,3H), 2.27-1.98(m,3H), 1.93 -1.67(m,6H), 1.59-1.26(m,3H), 1.09-0.99(m,1H), 0.85-0.75(m,1H).

Example 69: (3 S ) -N- [1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2-[(2 R )-2 -(2,5-difluoroaniline)propionyl]-2-azabicyclo[2.2.2]octane-3-carboxamide (compound 75)

By adding ( S ) -N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-2-azabicyclo[2.2.2] Octane-3-formamide 4-toluenesulfonate was coupled with an appropriate carboxylic acid to react with respect to (1 S ,3 S ,4 S )-2-[(2 R )-2-(3-chloroanilino )-4-methyl-pentyl] -N -[( 1S )-1-cyano-2-[( 3S )-2-oxo-3-piperidinyl]ethyl]-5 , 5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide to prepare (3 S ) -N- [1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2-[(2 R )-2-(2,5-difluoroaniline)propionyl]-2-azabicyclo[2.2. 2] Octane-3-carboxamide; Observed m/z: 488[M+H]+; ¹ H NMR (400MHz, CD ₃ OD): δ 7.04-6.78(m, 1H), 6.64-6.43( m, 1H), 6.38-6.18(m, 1H), 5.17-4.98(m, 1H), 4.84-3.92(m, 3H), 3.25-3.08(m, 1H), 2.63-0.65(m, 20H).

Example 70: (3 S ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2-[( 2 S )-2-(2,5-difluoroaniline)propionyl]-2-azabicyclo[2.2.2]octane-3-carboxamide (compound 76)

By adding ( S ) -N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-2-azabicyclo[2.2.2] Octane-3-formamide 4-toluenesulfonate was coupled with an appropriate carboxylic acid to react with respect to (1 S ,3 S ,4 S )-2-[(2 R )-2-(3-chloroanilino )-4-methyl-pentyl] -N -[( 1S )-1-cyano-2-[( 3S )-2-oxo-3-piperidinyl]ethyl]-5 , 5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide to prepare (3 S ) -N -[(1 S )-1-cyano-2 -[(3 S )-2-oxo-3-piperidinyl]ethyl]-2-[(2 S )-2-(2,5-difluoroaniline)propionyl]-2-nitrogen Heterobicyclo[2.2.2]octane-3-carboxamide; observed m/z: 488[M+H] ⁺ ; ¹ H NMR (400MHz, CD ₃ OD): δ 7.00-6.85 (m, 1H) , 6.62-6.40(m,1H), 6.36-6.21(m,1H), 5.15-4.96(m,1H), 4.62-4.42(m,1H), 4.31-3.99(m,2H), 3.29-3.23( m, 1H), 2.61-0.85 (m, 20H).

Example 71: (1 S ,3 S ,4 S ) -N -((S)-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5 , 5-difluoro-2-(2-hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide (single diastereoisomer I)( Compounds 77 and 78)

By adding (1 S ,3 S ,4 S ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]- 5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamide 4-toluenesulfonate was coupled with an appropriate carboxylic acid to react with respect to ( 1S , 3S , 4S ) -2-[(2 R )-2-(3-chloroanilino)-4-methyl-pentyl] -N -[(1 S )-1-cyano-2-[(3 S )- 2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide was prepared in an analogous manner (1 S ,3 S ,4 S ) -N -((S)-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro- 2-(2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide (mixture of diastereoisomers). The diastereoisomers were separated by chiral SFC on a CHIRALCEL IC column using MeOH/ _CH3CN (1:1 isocratic, 25% mobile phase).

Minor diastereomer (compound 77) : (single diastereomer I, faster eluting diastereomer): (1 mg, 3% yield, observed m/z: 475[M+H] ⁺ ); ¹ H NMR (400MHz, CD ₃ OD): δ ¹ H NMR (400MHz, CD ₃ OD): δ 7.41(s,5H), 5.50(d,1H), 5.06-4.98 (m,1H), 4.45(s,1H), 4.19(s,1H), 2.54(d,2H), 2.27(m,1H), 2.10-1.96(m,3H), 1.95-1.79(m,2H ), 1.77-1.50(m,6H), 1.30(d,2H).

Minor diastereomer (compound 78) : (single diastereomer II, slower eluting diastereomer): (2.4 mg, 7% yield, observed m/z : 475[M+H] ⁺ ); ¹ H NMR (400MHz, CD ₃ OD): δ 7.56-7.23 (m, 5H), 5.41 (s, 1H), 5.13 (dd, 1H), 4.45 (s, 1H ), 4.19(s,1H), 3.28-3.24(m,1H), 2.62-2.32(m,3H), 2.14-2.04(m,1H), 2.02-1.63(m,7H), 1.56(d,2H ), 1.39-1.04(m,2H).

Example 72: (1 S ,3 S ,4 S )-2-[(2 R )-2-(3-chloroanilino)-4-methyl-pentyl] -N -[(1 S ) -1-cyano-2-[(3S)-2-oxopyrrolidin-3-yl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3- Formamide (compound 79)

Step (1): (1S,3S,4S)-3-[[(1S)-1-cyano-2-[(3S)-2-oxopyrrolidin-3-yl]ethyl Base]carbamoyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-2-carboxylic acid tert-butyl ester

To (1S,3S,4S)-3-[[(1S)-2-amino-2-oxo-1-[[(3S)-2-oxopyrrolidin-3-yl]methyl] Ethyl]carbamoyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-2-carboxylic acid tert-butyl ester (134 mg, 0.3 mmol) in anhydrous CH ₂ Cl ₂ ( 3 mL) was added Burgess reagent (144 mg, 0.6 mmol). The reaction mixture was stirred at room temperature for 2 hours. To the reaction mixture were added saturated aqueous sodium bicarbonate solution (8 mL) and aqueous brine solution (8 mL). The aqueous phase was extracted with EtOAc (3 x 15 mL) and the combined organic phases were dried over anhydrous sodium sulfate, filtered, and concentrated in vacuo. The crude residue was purified by normal phase _SiO2 column chromatography (5-10% MeOH/ _CH2Cl2 ) to afford (1S,3S,4S)-3-[[(1S)-1-cyano- ₂ -[(3S)-2-Oxopyrrolidin-3-yl]ethyl]aminoformyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-2-carboxylic acid Tert-butyl ester, as a white solid (94 mg, 73% yield, observed m/z: 427 [M+H] ⁺ ).

Step (2): (1S,3S,4S)-N-[(1S)-1-cyano-2-[(3S)-2-oxopyrrolidin-3-yl]ethyl]-5,5 -Difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide 4-toluenesulfonate

To (1S,3S,4S)-3-[[(1S)-1-cyano-2-[(3S)-2-oxopyrrolidin-3-yl]ethyl]carbamoyl]-5 , A solution of tert-butyl 5-difluoro-2-azabicyclo[2.2.2]octane-2-carboxylate (37 mg, 0.09 mmol) in EtOH (1 mL) was added p-toluenesulfonic acid monohydrate ( 18 mg, 0.1 mmol). The reaction mixture was stirred at 90 °C for 1 h and concentrated in vacuo to give ( 1S , 3S , 4S ) -N -[( 1S )-1-cyano-2-[( 3S )- 2-oxopyrrolidin-3-yl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide 4-toluenesulfonate, colorless oil (43 mg, 99% yield, observed m/z: 327 [M+H] ⁺ ), which was used in the next step without further purification.

Step (3): (1S,3S,4S)-2-[(2R)-2-(3-Chloroanilino)-4-methyl-pentyl]-N-[(1S)-1-cyano Base-2-[(3S)-2-oxopyrrolidin-3-yl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide

To (2 R )-2-(3-chloroanilino)-4-methyl-pentanoic acid (21 mg, 0.09 mmol) and (1 S ,3 S ,4 S ) -N -[(1 S )-1 -cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl A solution of amide 4-tosylate (43 mg, 0.09 mmol) in DMF (0.5 mL) was added DIPEA (60 μL, 0.35 mmol). The mixture was cooled to 0 °C and a solution of HATU (39 mg, 0.1 mmol) in DMF (0.5 mL) was added dropwise. The reaction mixture was warmed to room temperature and stirred at room temperature for 30 min. The mixture was filtered and purified by reverse phase preparative HPLC to give ( 1S , 3S , 4S )-2-[( 2R )-2-(3-chloroanilino)-4-methyl-pentyl] - N -[(1 S )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-5,5-difluoro-2-azabicyclo[ 2.2.2] Octane-3-carboxamide as a white solid (16 mg, 34% yield, observed m/z: 550 [M+H] ⁺ ); ¹ H NMR (400 MHz, CD ₃ OD): δ 7.16-6.99(m,1H), 6.70-6.42(m,3H), 5.13-4.96(m,1H), 4.60(s,1H), 4.48-4.36(m,1H), 4.30-4.16(m, 1H), 3.18-2.94 (m, 2H), 2.72-2.47 (m, 2H), 2.40-1.45 (m, 13H), 1.11-0.89 (m, 6H).

Example 73: (1 S ,3 S ,4 S ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl] -2-[(2 R )-3-cyclopropyl-2-[(5-methyl-3-pyridyl)amino]propionyl]-5,5-difluoro -2-Azabicyclo[2.2.2]octane-3-formamide (Compound 80)

By adding (1 S ,3 S ,4 S ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-5 , 5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide 4-toluenesulfonate and appropriate carboxylic acid coupling with respect to (1 S ,3 S ,4 S )- 2-[(2 R )-2-(3-chloroanilino)-4-methyl-pentyl] -N -[(1 S )-1-cyano-2-[(3 S )-2 -Oxopyrrolidin-3-yl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide was prepared in an analogous manner ( 1S , 3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[(2 R ) -3-Cyclopropyl-2-[(5-methyl-3-pyridyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3 - Formamide; Observed m/z: 529[M+H] ⁺ ; ¹ H NMR (400MHz, CD ₃ OD): δ 7.80(d,1H), 7.64(d,1H), 7.00-6.87(m ,1H), 5.05-4.98(m,1H), 4.61(s,1H), 4.53-4.42(m,2H), 3.10-2.99(m,1H), 2.96-2.84(m,1H), 2.66-2.52 (m,2H), 2.41-2.21(m,7H), 1.95-1.49(m,7H), 1.34-1.21(m,1H), 0.97-0.84(m,1H), 0.57-0.48(m,2H) , 0.25-0.12 (m, 2H).

Example 74: (1 S ,3 S ,4 S )-5,5-difluoro- N -[( E ,1 S )-3-fluoro-3-methylsulfonyl-1-[[(3 S )-2-oxopyrrolidin-3-yl]methyl]allyl]-2-(9-hydroxyl-9-carbonyl)-2-azabicyclo[2.2.2]octane-3- Formamide (Compound 81)

Step (1): tertiary butyl N-[(1S)-1-(hydroxymethyl)-2-[(3S)-2-oxopyrrolidin-3-yl]ethyl]carbamate

To (2S)-2-(tert-butoxycarbonylamino)-3-[(3S)-2-oxopyrrolidin-3-yl]propanoic acid methyl ester (3.8 g, 13.4 mmol) within 3 hours Sodium borohydride (8.1 g, 215 mmol) was added portionwise to a solution in MeOH (200 mL). The reaction mixture was stirred at room temperature for 16 hours. To the mixture was added _H2O (150 mL) and it was concentrated in vacuo to remove MeOH. The aqueous phase was then extracted with EtOAc (3 x 200 mL). The combined organic phases were dried over anhydrous sodium sulfate, filtered and concentrated under vacuum. The crude residue was triturated with _Et2O (30 mL) and filtered to give N-[(1S)-1-(hydroxymethyl)-2-[(3S)-2-oxopyrrolidin-3-yl] tert-butyl ethyl]carbamate as a white solid (3.3 g, 95% yield, observed m/z: 259 [M+H] ⁺ ).

Step (2): tertiary butyl N-[(1S)-1-formyl-2-[(3S)-2-oxopyrrolidin-3-yl]ethyl]carbamate

To tertiary butyl N-[(1S)-1-(hydroxymethyl)-2-[(3S)-2-oxopyrrolidin-3-yl]ethyl]carbamate (3.3g, 12.7mmol ) in _CH2Cl2 (50 _mL ) was added Dess-Martin periodate (8.5 g, 20 mmol) and sodium bicarbonate (1.7 g, 20 mmol). The reaction mixture was stirred at room temperature for 2 hours, filtered, and concentrated under vacuum. The crude residue was purified by normal phase SiO ₂ column chromatography (0-10% MeOH/CH ₂ Cl ₂ ) to afford N-[(1S)-1-formyl-2-[(3S)-2- tert-butyl oxopyrrolidin-3-yl]ethyl]carbamate as a yellow solid (2.0 g, 62% yield, observed m/z: 257 [M+H] ⁺ ).

Step (3): 1-[Ethoxy-[fluoro(methylsulfonyl)methyl]phosphoryl]oxirane

To a solution of 1-[ethoxy(methylsulfonylmethyl)phosphoryl]oxirane (1.0 g, 4.3 mmol) in THF (12 mL) was added KHMDS (1.0 M in THF, 5.4 mL, 5.4 mmol). The reaction mixture was stirred at -78°C for 45 min and Selectfluor ^™ (2.3 g, 6.5 mmol) was added. The mixture was stirred at -78°C for 5 min and DMF (8 mL) was added. The reaction mixture was warmed to 0 °C and stirred for 3 hours. To the mixture were added _CH2Cl2 (10 _mL ) and saturated aqueous ammonium chloride (10 mL) at 0 °C. The mixture was slowly warmed to room temperature with stirring and concentrated in vacuo to remove volatiles. The aqueous phase was extracted with _CH2Cl2 (3 _x 25 mL). The combined organic phases were washed with saturated aqueous sodium bicarbonate solution (20 mL) and aqueous brine solution (20 mL), dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. The crude residue was purified by normal phase _SiO2 column chromatography (20-50% EtOAc/hexanes) to afford the 1-[ethoxy-[fluoro(methylsulfonyl)methyl]phosphoryl] ring Oxyethane, a colorless oil (504 mg, 47% yield, observed m/z: 249 [M+H] ⁺ ).

Step (4): ((S)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-ene-2- base) tertiary butyl carbamate

Solution at -78 °C To 1-[ethoxy-[fluoro(methylsulfonyl)methyl]phosphoryl]oxirane (496 mg, 2 mmol) in anhydrous THF (6 mL) was added dropwise KHMDS (1.0 M in THF, 2.1 mL, 2.1 mmol). The mixture was stirred at -78°C for 30min and N-[(1S)-1-formyl-2-[(3S)-2-oxopyrrolidine-3- A solution of tert-butyl]ethyl]carbamate (769 mg, 3 mmol) in anhydrous THF (4 mL). The reaction mixture was stirred at -78 °C for 2 h, quenched with _H2O (15 mL) and slowly warmed to room temperature. The aqueous phase was extracted with EtOAc (3 x 20 mL). The combined organic phases were dried over anhydrous sodium sulfate, filtered and concentrated under vacuum. The crude residue was purified by normal phase SiO ₂ chromatography (50-100% EtOAc/CH ₂ Cl ₂ ) to afford N-[(Z,1S)-3-fluoro-3-methylsulfonyl-1-[ Tertiary butyl [(3S)-2-oxopyrrolidin-3-yl]methyl]allyl]carbamate as a white solid (faster eluting isomer, 174 mg, 25% yield , observed m/z: 351 [M+H] ⁺ ); and N-[(E,1S)-3-fluoro-3-methylsulfonyl-1-[[(3S)-2-oxo tertiary butyl pyrrolidin-3-yl]methyl]allyl]carbamate as a white solid (slower eluting isomer, 180 mg, 26% yield, observed m/z: 351 [ M+H] ⁺ ).

Step (5): (3S)-3-[(E,2S)-2-Amino-4-fluoro-4-methylsulfonyl-but-3-enyl]pyrrolidin-2-one

烷溶液，2mL)。將反應混合物在室溫下攪拌30min並在真空下濃縮。將粗殘餘物用Et₂O(5mL)研磨並過濾，得到(3S)-3-[(E,2S)-2-胺基-4-氟-4-甲基磺醯基-丁-3-烯基]吡咯啶-2-酮的鹽酸鹽，為白色固體(108mg，產率76%，觀察到m/z：251[M+H]⁺)。 To N-[(E,1S)-3-fluoro-3-methylsulfonyl-1-[[(3S)-2-oxopyrrolidin-3-yl]methyl]allyl]amino To a solution of tert-butyl formate (174 mg, 0.5 mmol) in CH ₂ Cl ₂ (1 mL) was added hydrochloric acid (4M in 1,4-di

alkane solution, 2 mL). The reaction mixture was stirred at room temperature for 30 min and concentrated under vacuum. The crude residue was triturated with _Et2O (5 mL) and filtered to give ( 3S )-3-[( E , 2S )-2-amino-4-fluoro-4-methylsulfonyl-butan- Hydrochloride salt of 3-enyl]pyrrolidin-2-one as a white solid (108 mg, 76% yield, observed m/z: 251 [M+H] ⁺ ).

Step (6): (1S,3S,4S)-5,5-Difluoro-3-[[(E,1S)-3-fluoro-3-methylsulfonyl-1-[[(3S)- 2-Oxopyrrolidin-3-yl]methyl]allyl]carbamoyl]-2-azabicyclo[2.2.2]octane-2-carboxylic acid tert-butyl ester

To (1 S ,3 S ,4 S )-2-tert-butoxycarbonyl-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxylic acid (51mg, 0.17mmol ) and ( 3S )-3-[( E , 2S )-2-amino-4-fluoro-4-methylsulfonyl-but-3-enyl]pyrrolidin-2-one hydrochloride (50 mg, 0.17 mmol) in CH ₂ Cl ₂ (2 mL) was added 2-pyridinol 1-oxide (39 mg, 0.35 mmol), EDC.HCl (43 mg, 0.23 mmol) and DIPEA (122 μL, 0.7 mmol) . The reaction mixture was stirred at room temperature for 2 hours. The mixture was diluted with _CH2Cl2 (30 mL), washed with 0.5N aqueous hydrochloric acid (10 mL) and aqueous brine solution (10 _mL ). The organic phase was dried over anhydrous sodium sulfate, filtered and concentrated under vacuum. The crude residue was purified by normal phase SiO ₂ column chromatography (0-4% MeOH/CH ₂ Cl ₂ ) to afford (1S,3S,4S)-5,5-difluoro-3-[[(E, 1S)-3-fluoro-3-methylsulfonyl-1-[[(3S)-2-oxopyrrolidin-3-yl]methyl]allyl]carbamoyl]-2-nitrogen Tert-butyl heterobicyclo[2.2.2]octane-2-carboxylate as off-white solid (32 mg, 35% yield, observed m/z: 524 [M+H] ⁺ ).

Step (7): (1S,3S,4S)-5,5-Difluoro-N-[(E,1S)-3-fluoro-3-methylsulfonyl-1-[[(3S)-2 -Oxopyrrolidin-3-yl]methyl]allyl]-2-azabicyclo[2.2.2]octane-3-carboxamide

烷溶液，2mL)。將反應混合物在室溫下攪拌1小時，並在真空中濃縮。將粗殘餘物用Et₂O(5mL)研磨並過濾，得到(1S,3S,4S)-5,5-二氟-N-[(E,1S)-3-氟-3-甲基磺醯基-1-[[(3S)-2-氧代吡咯啶-3-基]甲基]烯丙基]-2-氮雜雙環[2.2.2]辛烷-3-甲醯胺的鹽酸鹽，為白色固體(定量獲得30mg，觀察到m/z：424[M+H]⁺)，其 無需進一步純化即可用於下一步。 To (1S,3S,4S)-5,5-difluoro-3-[[(E,1S)-3-fluoro-3-methylsulfonyl-1-[[(3S)-2-oxo Pyrrolidin-3-yl]methyl]allyl]carbamoyl]-2-azabicyclo[2.2.2]octane-2-carboxylic acid tert-butyl ester (32mg, 0.06mmol) in _CH2 A solution in Cl ₂ (1 mL) was added with hydrochloric acid (4M 1,4-di

alkane solution, 2 mL). The reaction mixture was stirred at room temperature for 1 hour and concentrated in vacuo. The crude residue was triturated with _Et2O (5 mL) and filtered to give ( 1S , 3S , 4S )-5,5-difluoro- N -[( E , 1S )-3-fluoro-3- Methylsulfonyl-1-[[(3 S )-2-oxopyrrolidin-3-yl]methyl]allyl]-2-azabicyclo[2.2.2]octane-3-methyl The hydrochloride salt of the amide, a white solid (30 mg obtained quantitatively, observed m/z: 424 [M+H] ⁺ ), was used in the next step without further purification.

Step (8): (1S,3S,4S)-5,5-Difluoro-N-[(E,1S)-3-fluoro-3-methylsulfonyl-1-[[(3S)-2 -Oxopyrrolidin-3-yl]methyl]allyl]-2-(9-hydroxyl-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formamide

To (1 S ,3 S ,4 S )-5,5-difluoro- N -[( E ,1 S )-3-fluoro-3-methylsulfonyl-1-[[(3 S )- 2-oxopyrrolidin-3-yl]methyl]allyl]-2-azabicyclo[2.2.2]octane-3-carboxamide hydrochloride (15mg, 0.03mmol) and 9-hydroxy To a solution of terpene-9-carboxylic acid (7.4 mg, 0.03 mmol) in DMF (0.5 mL) was added DIPEA (23 μL, 0.13 mmol) and HATU (19 mg, 0.05 mmol). The reaction mixture was stirred at room temperature for 15 min, filtered and purified by reverse phase HPLC to afford ( 1S , 3S , 4S )-5,5-difluoro- N -[( E , 1S )-3-fluoro -3-Methylsulfonyl-1-[[(3 S )-2-oxopyrrolidin-3-yl]methyl]allyl]-2-(9-hydroxyl-9-carbonyl)- 2-Azabicyclo[2.2.2]octane-3-carboxamide as a colorless film (3.9 mg, 19% yield, observed m/z: 632 [M+H] ⁺ ), ¹ H NMR ( 400MHz, CD ₃ OD): δ 7.87-7.77(m,2H), 7.58-7.44(m,3H), 7.44-7.35(m,3H), 6.16(dd,1H), 5.03-4.95(m,1H) , 4.54(d,1H), 3.47-3.37(m,2H), 3.19(d,1H), 3.11(s,3H), 2.82(m,1H), 2.59-2.49(m,1H), 2.41(s ,1H), 2.22(m,1H), 1.93-1.83(m,1H), 1.65(m,1H), 1.51(t,2H), 1.46-1.37(m,1H), 1.34-1.17(m,2H ), 0.92(s,1H).

Example 75: (3 S ,3a S ,6a R ) -N -[( E ,1 S )-3-fluoro-3-methylsulfonyl-1-[[(3 S )-2-oxo Pyrrolidin-3-yl]methyl]allyl]-2-(9-hydroxyl-9-carbonyl)-3,3a,4,5,6,6a-hexahydro-1H-cyclopentadiene [c] Pyrrole-3-carboxamide (compound 82)

By adding ( 3S )-3-[( E , 2S )-2-amino-4-fluoro-4-methylsulfonyl-but-3-enyl]pyrrolidin-2-one hydrochloride Coupling with an appropriate carboxylic acid to react with ( 1S , 3S , 4S )-5,5-difluoro- N -[( E , 1S )-3-fluoro-3-methylsulfonyl-1 -[[(3 S )-2-oxopyrrolidin-3-yl]methyl]allyl]-2-(9-hydroxyl-9-carbonyl)-2-azabicyclo[2.2.2] (3 S ,3a S ,6a R ) -N -[( E ,1 S )-3-fluoro-3-methylsulfonyl-1- [[(3 S )-2-oxopyrrolidin-3-yl]methyl]allyl]-2-(9-hydroxyl-9-carbonyl)-3,3a,4,5,6,6a - Hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamide as a white solid; observed m/z: 596[M+H] ⁺ ; ¹ H NMR (400MHz, CD ₃ OD) : δ 8.63(d,1H), 7.82-7.75(m,2H), 7.52-7.42(m,2H), 7.42-7.31(m,2H), 6.13(dd,1H), 4.99-4.92(m,1H ), 4.20(d,1H), 3.64(d,1H), 3.45-3.36(m,2H), 3.11(s,3H), 2.87-2.74(m,1H), 2.68-2.59(m,1H), 2.55-2.16(m,5H), 1.94-1.82(m,1H), 1.84-1.72(m,1H), 1.68-1.36(m,4H), 0.94-0.86(m,1H), 0.69-0.56(m ,1H).

Example 76: (3 S ,3a S ,6a R )-2-[(2 R )-2-Acetamido-2-phenyl-acetyl] -N -[( E ,1 S )- 3-Fluoro-3-methylsulfonyl-1-[[(3 S )-2-oxopyrrolidin-3-yl]methyl]allyl]-3,3a,4,5,6, 6a-hexahydro-1H-cyclopentadieno[c]pyrrole-3-carboxamide (compound 83)

By adding ( 3S )-3-[( E , 2S )-2-amino-4-fluoro-4-methylsulfonyl-but-3-enyl]pyrrolidin-2-one hydrochloride Coupling with an appropriate carboxylic acid to react with ( 1S , 3S , 4S )-5,5-difluoro- N -[( E , 1S )-3-fluoro-3-methylsulfonyl-1 -[[(3 S )-2-oxopyrrolidin-3-yl]methyl]allyl]-2-(9-hydroxyl-9-carbonyl)-2-azabicyclo[2.2.2] (3 S ,3a S ,6a R )-2-[(2 R )-2-acetamido-2-phenyl-acetyl] was prepared in a similar manner as described for octane-3-formamide - N -[( E ,1 S )-3-fluoro-3-methylsulfonyl-1-[[(3 S )-2-oxopyrrolidin-3-yl]methyl]allyl] -3,3a,4,5,6,6a-Hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamide as a white solid; observed m/z: 563 [M+H] ⁺ ; ¹ H NMR (400MHz, CD ₃ OD): δ 8.59(d,1H), 8.35(d,1H), 8.12(s,1H), 7.48-7.31(m,3H), 6.21(dd,1H) , 5.68-5.56(m,1H), 4.19(d,1H), 3.98(m,1H), 3.38-3.32(m,2H), 3.26-3.06(m,4H), 2.78-2.52(m,3H) , 2.46-2.34(m,1H), 2.31-2.20(m,1H), 1.99(s,3H), 1.96-1.77(m,2H), 1.72-1.54(m,2H), 1.53-1.35(m, 3H), 1.04-0.87 (m, 1H).

Example 77: ( 3S , 3aS , 6aR )-2-[( 2S )-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino] Butyl] -N -[( Z ,1 S )-3-fluoro-3-methylsulfonyl-1-[[(3 S )-2-oxopyrrolidin-3-yl]methyl]allyl Base]-3,3a,4,5,6,6a-hexahydro-1H-cyclopentadieno[c]pyrrole-3-carboxamide (compound 84)

Step (1): (3S,3aS,6aR)-2-[(2S)-2-(tert-butoxycarbonylamino)-3,3-dimethyl-butyryl]-3,3a,4, 5,6,6a-Hexahydro-1H-cyclopenta[c]pyrrole-3-carboxylic acid ethyl ester

To (3S,3aS,6aR)-1,2,3,3a,4,5,6,6a-octahydrocyclopenta[c]pyrrole-3-carboxylic acid ethyl ester hydrochloride (439mg, 2mmol) and ( 2S )-2-(tert-butoxycarbonylamino)-3,3-dimethyl-butanoic acid (463 mg, 2 mmol) in DMF (8 mL) was added DIPEA (1.4 mL, 8 mmol) and HATU (1.1 g, 3 mmol). The reaction mixture was stirred at room temperature for 1 hour. EtOAc (100 mL) was added to the reaction mixture and the organic phase was washed with 0.5M aqueous hydrochloric acid (50 mL) and aqueous brine solution (50 mL). The organic phase was then dried over anhydrous sodium sulfate, filtered and concentrated under vacuum. Purification of the crude residue by normal phase _SiO column chromatography (10-20% EtOAc/hexanes) afforded (3S,3aS,6aR)-2-[(2S)-2-(tert-butoxycarbonyl Amino)-3,3-dimethyl-butyryl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxylic acid ethyl ester, for Colorless oil (435 mg, 55% yield, observed m/z: 397 [M+H] ⁺ ).

Step (2): (3S,3aS,6aR)-2-[(2S)-2-(tert-butoxycarbonylamino)-3,3-dimethyl-butyryl]-3,3a,4, 5,6,6a-Hexahydro-1H-cyclopenta[c]pyrrole-3-carboxylic acid

烷(2mL)中的溶液加入氫氧化鋰(53mg，2.2mmol)在H₂O(4mL)中的溶液。將反應混合物在室溫下攪拌30min。向該混合物加入1M水性鹽酸(8mL)並用EtOAc(3×30mL)萃取水相。將合併後的有機相經無水硫酸鈉乾燥，過濾，並在真空下濃縮，得到(3S,3aS,6aR)-2-[(2S)-2-(第三丁氧基羰基胺基)-3,3-二甲基-丁醯基]-3,3a,4,5,6,6a-六氫-1H-環戊二烯并[c]吡咯-3-羧酸，為白色固體(定量獲得410mg，觀察到m/z：369[M+H]⁺)，其無需進一步純化即可用於下一步。 To (3S,3aS,6aR)-2-[(2S)-2-(tertiary butoxycarbonylamino)-3,3-dimethyl-butyryl]-3,3a,4,5,6, 6a-Hexahydro-1H-cyclopentadieno[c]pyrrole-3-carboxylic acid ethyl ester (435mg, 1.1mmol) in 1,4-bis

A solution in alkanes (2 mL) was added to a solution of lithium hydroxide (53 mg, 2.2 mmol) in _H2O (4 mL). The reaction mixture was stirred at room temperature for 30 min. To the mixture was added 1M aqueous hydrochloric acid (8 mL) and the aqueous phase was extracted with EtOAc (3 x 30 mL). The combined organic phases were dried over anhydrous sodium sulfate, filtered, and concentrated in vacuo to give ( 3S , 3aS , 6aR )-2-[( 2S )-2-(tert-butoxycarbonylamine base)-3,3-dimethyl-butyryl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxylic acid as a white solid ( 410 mg was obtained quantitatively, m/z observed: 369 [M+H] ⁺ ), which was used in the next step without further purification.

Step (3): (3S,3aS,6aR)-2-[(2S)-2-Amino-3,3-dimethyl-butyryl]-3,3a,4,5,6,6a-hexahydro -1H-cyclopenta[c]pyrrole-3-carboxylate hydrochloride

烷溶液(4mL)。將反應混合物在室溫下攪拌30min並在真空下濃縮。在Et₂O(10mL)中研磨粗殘餘物並過濾，得到(3S,3aS,6aR)-2-[(2S)-2-胺基-3,3-二甲基-丁醯基]-3,3a,4,5,6,6a-六氫-1H-環戊二烯并[c]吡咯-3-羧酸的鹽酸鹽，為白色固體(235mg，產率70%，觀察到m/z：269[M+H]⁺)。 To (3 S ,3a S ,6a R )-2-[(2 S )-2-(tertiary butoxycarbonylamino)-3,3-dimethyl-butyryl]-3,3a,4, A solution of 5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxylic acid (404 mg, 1.1 mmol) in CH ₂ Cl ₂ (1 mL) was added to 1,4- two

alkane solution (4 mL). The reaction mixture was stirred at room temperature for 30 min and concentrated under vacuum. The crude residue was triturated in _Et2O (10 mL) and filtered to give ( 3S , 3aS , 6aR )-2-[( 2S )-2-amino-3,3-dimethyl-butyryl] - The hydrochloride salt of 3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxylic acid as a white solid (235 mg, yield 70%, observed m/z: 269[M+H] ⁺ ).

Step (4): (3S,3aS,6aR)-2-[(2S)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]- 3,3a,4,5,6,6a-Hexahydro-1H-cyclopenta[c]pyrrole-3-carboxylic acid

To (3 S ,3a S ,6a R )-2-[(2 S )-2-amino-3,3-dimethyl-butyryl]-3,3a,4,5,6, A solution of 6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxylate hydrochloride (235 mg, 0.8 mmol) in MeOH (2 mL) was added with TEA (752 μL, 5.4 mmol), followed by trifluoro Ethyl acetate (257 μL, 2.16 mmol). The reaction mixture was stirred at room temperature for 2 hours. 1M aqueous hydrochloric acid (10 mL) was added to the reaction mixture and the aqueous phase was extracted with EtOAc (3 x 25 mL). The combined organic phases were dried over anhydrous sodium sulfate, filtered, and concentrated in vacuo to give ( 3S , 3aS , 6aR )-2-[( 2S )-3,3-dimethyl-2- [(2,2,2-Trifluoroacetyl)amino]butyryl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxy Acid as a white solid (242 mg, 86% yield, observed m/z: 365 [M+H] ⁺ ).

Step (5): (3S,3aS,6aR)-2-[(2S)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amine Base]butyryl]-N-[(Z,1S)-3-fluoro-3-methylsulfonyl-1-[[(3S)-2-oxopyrrolidin-3-yl]methyl]allyl base]-3,3a,4,5,6,6a-hexahydro-1H-cyclopentadieno[c]pyrrole-3-carboxamide

To (3 S ,3a S ,6a R )-2-[(2 S )-3,3-dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]- 3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxylic acid (55mg, 0.15mmol) and ( 3S )-3-[( Z ,2 S )-2-amino-4-fluoro-4-methylsulfonyl-but-3-enyl]pyrrolidin-2-one hydrochloride (43mg, 0.15mmol) in butane-2-one ( 1 mL) was added 2-hydroxypyridine 1-oxide (4.17 mg, 0.04 mmol), and the mixture was cooled to 0°C. To this mixture was added dropwise DIPEA (105 μL, 78 mg, 0.6 mmol) and ( 3S )-3-[( Z , 2S )-2-amino-4-fluoro-4-methylsulfonyl-butyl- A solution of 3-enyl]pyrrolidin-2-one hydrochloride (43 mg, 0.15 mmol) in butan-2-one (0.5 mL). The reaction mixture was stirred at room temperature for 2 hours. EtOAc (50 mL) was added to the reaction mixture and the organic phase was washed with 1M aqueous hydrochloric acid (20 mL) and aqueous brine solution (20 mL). The organic phase was dried over anhydrous sodium sulfate, filtered and concentrated under vacuum. The crude residue was purified by normal phase SiO ₂ column chromatography (2-5% MeOH/CH ₂ Cl ₂ ) and then repurified by reverse phase HPLC to give ( 3S , 3aS , 6aR )-2-[ (2 S )-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl] -N -[( Z ,1 S )-3-fluoro-3 -Methylsulfonyl-1-[[(3 S )-2-oxopyrrolidin-3-yl]methyl]allyl]-3,3a,4,5,6,6a-hexahydro- 1H-cyclopenta[c]pyrrole-3-carboxamide as a white solid (31 mg, 35% yield, observed m/z: 597 [M+H] ⁺ ); ¹ H NMR (400 MHz, CD ₃ OD): δ 8.49(d,1H), 6.00(dd,1H), 5.52-5.35(m,1H), 4.65(s,1H), 4.08(d,1H), 3.96(m,1H), 3.76(m,1H), 3.23(s,3H), 2.88-2.68(m,2H), 2.62(m,1H), 2.33(m,1H), 2.22-2.09(m,2H), 1.98-1.59( m,7H), 1.55-1.43(m,2H), 1.06(s,9H).

Example 78: ( 3S , 3aS , 6aR )-2-[( 2S )-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino] Butyl] -N -[( E ,1 S )-3-fluoro-3-methylsulfonyl-1-[[(3 S )-2-oxopyrrolidin-3-yl]methyl]allyl Base]-3,3a,4,5,6,6a-hexahydro-1H-cyclopentadieno[c]pyrrole-3-carboxamide (compound 85)

By adding ( 3S )-3-[( E , 2S )-2-amino-4-fluoro-4-methylsulfonyl-but-3-enyl]pyrrolidin-2-one hydrochloride and appropriate carboxylic acid coupling with respect to (3 S ,3a S ,6a R )-2-[(2 S )-3,3-dimethyl-2-[(2,2,2-trifluoroacetyl base)amino]butyryl] -N -[( Z ,1 S )-3-fluoro-3-methylsulfonyl-1-[[(3 S )-2-oxopyrrolidin-3-yl] Methyl]allyl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamide was prepared in a manner similar to that described (3 S ,3a S ,6a R )-2-[(2 S )-3,3-dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl] -N -[( E ,1 S )-3-fluoro-3-methylsulfonyl-1-[[(3 S )-2-oxopyrrolidin-3-yl]methyl]allyl]-3,3a, 4,5,6,6a-Hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamide as a white solid; observed m/z: 597[M+H] ⁺ ; ¹ H NMR (400MHz, CD ₃ OD): δ 8.65(d,1H), 6.14(dd,1H), 4.99-4.92(m,1H), 4.66(s,1H), 4.08(d,1H), 4.01-3.93( m,1H), 3.82-3.72(m,1H), 3.13-3.09(m,3H), 2.88-2.54(m,3H), 2.43-2.33(m,1H), 2.26-2.11(m,2H), 1.99-1.61(m,7H), 1.60-1.42(m,2H), 1.07(s,9H).

Example 79: ( 3S , 3aS , 6aR )-2-[( 2S )-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino] Butyl] -N -[( E ,1 S )-3-fluoro-3-methylsulfonyl-1-[[(3 S )-2-oxopyrrolidin-3-yl]methyl]allyl Base]-3,3a,4,5,6,6a-hexahydro-1H-cyclopentadieno[c]pyrrole-3-carboxamide (Compound 86)

By adding ( S )-3-(( S , E )-2-amino-4-fluoro-4-(methylsulfonyl)but-3-en-1-yl)pyrrolidin-2-one salt Acid salts and appropriate carboxylic acids coupled to (3 S ,3a S ,6a R )-2-[(2 S )-3,3-dimethyl-2-[(2,2,2-trifluoro Acetyl)amino]butyryl] -N -[( Z ,1 S )-3-fluoro-3-methylsulfonyl-1-[[(3 S )-2-oxopyrrolidine-3- yl]methyl]allyl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamide in a manner similar to that described ( 1 S ,3a R ,6a S )-2-(( S )-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro - N -(( S , E )-4-fluoro-4-(methylsulfonyl)-1-(( S )-2-oxopyrrolidin-3-yl)but-3-ene-2- base) octahydrocyclopenta[ c ]pyrrole-1-carboxamide, as a white solid; observed m/z: 633[M+H] ⁺ ; ¹ H NMR (400MHz, DMSO-d ₆ ): δ 9.36 ( d,1H), 8.51(d,1H), 7.68-7.53(m,1H), 6.18-6.00(m,1H), 4.88-4.73(m,1H), 4.56-4.50(m,1H), 4.19( d,1H), 3.87-3.73(m,2H), 3.21(s,3H), 3.15(t,1H), 3.09-3.00(m,1H), 2.99-2.91(m,1H), 2.45-2.36( m, 3H), 2.31-1.88 (m, 5H), 1.68-1.55 (m, 1H), 1.44-1.33 (m, 1H), 1.03-0.94 (m, 9H).

Example 80: (1 S ,3 S ,4 S )-2-(7-chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-(( S ,E)-4- Fluoro-4-(methylsulfonyl)-1-(( S )-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2 ] Octane-3-formamide (compound 87)

By adding (1 S ,3 S ,4 S )-5,5-difluoro-N-(( S , E )-4-fluoro-4-(methylsulfonyl)-1-((S)- 2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide hydrochloride is coupled with an appropriate carboxylic acid to With respect to (1 S ,3 S ,4 S )-5,5-difluoro- N -[( E ,1 S )-3-fluoro-3-methylsulfonyl-1-[[(3 S ) -2-Oxopyrrolidin-3-yl]methyl]allyl]-2-(9-hydroxyl-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl ( 1S , 3S , 4S )-2-(7-chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-(( S ,E )-4-fluoro-4-(methylsulfonyl)-1-(( S )-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo [2.2.2] Octane-3-formamide; Observed m/z: 601[M+H] ⁺ ; ¹ H NMR (400MHz, DMSO- d ₆ , 353K): δ 11.39(s, 1H), 8.53(d,1H), 7.57(d,1H), 7.33(s,1H), 7.26(d,1H), 7.06(t,1H), 6.83(s,1H), 6.21-6.07(m,1H) , 4.86-4.60(m,3H), 3.17(s,3H), 3.15-3.00(m,2H), 2.67(s,1H), 2.46-2.00(m,6H), 1.78-1.58(m,4H) , 1.53-1.49 (m, 1H).

Example 81: (1 S ,3 S ,4 S )-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-5,5-difluoro-N-( ( S , E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2 -Azabicyclo[2.2.2]octane-3-formamide (Compound 88)

By adding (1 S ,3 S ,4 S )-5,5-difluoro-N-(( S ,E)-4-fluoro-4-(methylsulfonyl)-1-(( S )- 2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide hydrochloride is coupled with an appropriate carboxylic acid to With respect to (1 S ,3 S ,4 S )-5,5-difluoro- N -[( E ,1 S )-3-fluoro-3-methylsulfonyl-1-[[(3 S ) -2-Oxopyrrolidin-3-yl]methyl]allyl]-2-(9-hydroxyl-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl ( 1S , 3S , 4S )-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-5,5-difluoro -N-(( S , E )-4-fluoro-4-(methylsulfonyl)-1-(( S )-2-oxopyrrolidin-3-yl)but-3-ene-2- base)-2-azabicyclo[2.2.2]octane-3-carboxamide; observed m/z: 607 [M+H] ⁺ ; ¹ H NMR (400MHz, DMSO- d ₆ ): δ 12.28 -12.23(m,1H), 8.79-8.48(m,1H), 7.83-7.55(m,1H), 7.46-7.39(m,1H), 6.98-6.45(m,1H), 6.21-6.03(m, 1H), 4.86-4.74(m,2H), 4.71-4.44(m,1H), 3.29-3.21(m,3H), 3.18(s,2H), 2.63(s,1H), 2.39(dd,1H) , 2.29-2.02 (m, 4H), 1.81-1.27 (m, 6H).

Example 82: (1 S ,3 S ,4 S )-2-(4,7-difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-(( S , E ) -4-fluoro-4-(methylsulfonyl)-1-(( S )-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[ 2.2.2] Octane-3-formamide (compound 89)

By adding (1 S ,3 S ,4 S )-5,5-difluoro-N-(( S , E )-4-fluoro-4-(methylsulfonyl)-1-(( S )- 2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide hydrochloride is coupled with an appropriate carboxylic acid to With respect to (1 S ,3 S ,4 S )-5,5-difluoro- N -[( E ,1 S )-3-fluoro-3-methylsulfonyl-1-[[(3 S ) -2-Oxopyrrolidin-3-yl]methyl]allyl]-2-(9-hydroxyl-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl ( 1S , 3S , 4S )-2-(4,7-difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-(( S ,E)-4-fluoro-4-(methylsulfonyl)-1-(( S )-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2- Azabicyclo[2.2.2]octane-3-carboxamide; observed m/z: 603[M+H] ⁺ ; ¹ H NMR (400MHz, DMSO- d _6, 353K): δ 12.20(s, 1H), 8.53(d,1H), 7.35(s,1H), 6.98-6.85(m,1H), 6.90-6.72(m,2H), 6.21-6.03(m,1H), 4.86-4.61(m, 3H), 3.17(s,4H), 2.69-2.67(m,1H), 2.54-2.52(m,1H), 2.46-2.38(m,1H), 2.34(dd,1H), 2.29-2.04(m, 4H), 1.77-1.43 (m, 5H).

Example 83: (1 S ,3 S ,4 S )-2-(3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl Base)-5,5-difluoro-N-(( S , E )-4-fluoro-4-(methylsulfonyl)-1-(( S )-2-oxopyrrolidin-3-yl )but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide (single diastereoisomer I) (compounds 90 and 91)

To a solution of 4-toluenesulfonyl chloride (131 mg, 0.69 mmol) in THF (5 mL) was added (2S)-3,3-dimethyl-2-[(2,2,2-trifluoro Acetyl)amino]butanoic acid (130 mg, 0.57 mmol), DIEA (0.26 mL, 1.49 mmol) and DMAP (83 mg, 0.68 mmol). The reaction mixture was warmed to 20 °C and stirred for 2 hours. Add (1 S ,3 S ,4 S )-5,5-difluoro-N-[( E ,1 S )-3-fluoro-3-methylsulfonyl-1-[[(3 S )- 2-oxopyrrolidin-3-yl]methyl]allyl]-2-azabicyclo[2.2.2]octane-3-carboxamide hydrochloride (263mg, 0.57mmol) in THF (15mL ) in the solution. After 12 hours, the reaction mixture was quenched with water (10 mL) and extracted with ethyl acetate (15 mL×3). The combined organic layers were dried over sodium sulfate and concentrated under reduced pressure. Purification of the crude product by reverse-phase HPLC afforded ( 1S , 3S , 4S )-2-(3,3-dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)- 5,5-Difluoro-N-(( S , E )-4-fluoro-4-(methylsulfonyl)-1-(( S )-2-oxopyrrolidin-3-yl)butan- 3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide (60 mg, 36% yield, observed m/z: 633 [M+H] ⁺ ). The diastereoisomers were separated by SFC (0.1% iPrNH2 ) on a LUX Cellulose-2 column using 80:20 hexane/ _EtOH .

Minor diastereomer (compound 90) : (single diastereomer I, faster eluting diastereomer): (3 mg, 0.8% yield, observed m/z: 633[M+H] ⁺ ); ¹ H NMR (400MHz, DMSO- d ₆ ): δ 10.08-9.43(m, 1H), 8.83-8.50(m, 1H), 7.69(s, 1H), 6.19- 6.08(m,1H), 4.93-4.72(m,2H), 4.63-4.16(m,2H), 3.30-3.28(m,3H), 3.25-2.88(m,2H), 2.59(s,1H), 2.41-2.00 (m, 6H), 1.97-1.47 (m, 5H), 1.02-1.00 (m, 9H).

Major diastereomer (compound 91) : (single diastereomer II, slower eluting diastereomer): (12 mg, 3% yield, observed m/z: 633 [M+H] ⁺ ); ¹ H NMR (400MHz, DMSO- d ₆ ): δ 9.35(d,1H), 8.55(d,1H), 7.59(s,1H), 6.12(dd,1H), 4.85 -4.75(m,2H), 4.62(s,1H), 4.41(s,1H), 3.25(s,3H), 3.20-3.13(m,1H), 3.08-3.01(m,1H), 2.51-2.20 (m,5H), 2.07-2.00(m,2H), 1.67-1.57(m,4H), 1.44-1.36(m,1H), 1.02(s,9H).

Example 84: (Z,4S)-4-[[(1S,3S,4S)-2-[(2R)-2-(3-chloroanilino)-4-methyl-pentyl]-5 ,5-Difluoro-2-azabicyclo[2.2.2]octane-3-carbonyl]amino]-2-fluoro-5-[(3S)-2-oxopyrrolidin-3-yl]pentane -2-enoic acid ethyl ester (compound 92)

Step (1): (Z,4S)-4-(tert-butoxycarbonylamino)-2-fluoro-5-[(3S)-2-oxopyrrolidin-3-yl]pentan-2- ethyl acrylate

To a solution of ethyl 2-diethoxyphosphoryl-2-fluoro-acetate (1.9 g, 7.8 mmol) in anhydrous THF (10 mL) was added KHMDS (1 M in THF, 8.5 mL, 8.5 mmol). The reaction mixture was stirred at -78°C for 30 min and N-[(1S)-1-formyl-2-[(3S)-2-oxopyrrolidin-3-yl] was added dropwise at -78°C A solution of tert-butyl ethyl]carbamate (2.0 g, 7.8 mmol) in THF (5 mL). The reaction mixture was stirred at -78°C for 2 hours and slowly warmed to 0°C. _H2O (30 mL) was added to the reaction mixture and the aqueous phase was extracted with EtOAc (3 x 50 mL). The combined organic phases were dried over anhydrous sodium sulfate, filtered and concentrated under vacuum. The crude residue was purified by normal phase _SiO2 column chromatography (1-4% MeOH/ _{CH2Cl2 )} to afford (Z,4S)-4-(tert-butoxycarbonylamino)-2-fluoro -Ethyl 5-[(3S)-2-oxopyrrolidin-3-yl]pent-2-enoate as a white solid (1.0 g, 38% yield, observed m/z: 345 [M+ H] ⁺ ).

Step (2): (Z,4S)-4-Amino-2-fluoro-5-[(3S)-2-oxopyrrolidin-3-yl]pent-2-enoic acid ethyl ester

烷溶液，2mL，8mmol)。將反應混合物在室溫下攪拌1小時，並在真空中濃縮，以提供(Z,4S)-4-胺基-2-氟-5-[(3S)-2-氧代吡咯啶-3-基]戊-2-烯酸乙酯的鹽酸鹽，為白色固體(定量獲得195mg，觀察到m/z：245[M+H]⁺)。 To (Z,4S)-4-(tert-butoxycarbonylamino)-2-fluoro-5-[(3S)-2-oxopyrrolidin-3-yl]pent-2-enoic acid ethyl ester (240 mg, 0.7 mmol) in CH ₂ Cl ₂ (2 mL) was added hydrochloric acid (4M of 1.4-di

alkane solution, 2mL, 8mmol). The reaction mixture was stirred at room temperature for 1 hour and concentrated in vacuo to provide (Z,4S)-4-amino-2-fluoro-5-[(3S)-2-oxopyrrolidine-3- Hydrochloride of ethyl]pent-2-enoic acid ethyl ester as a white solid (quantitatively obtained 195 mg, observed m/z: 245 [M+H] ⁺ ).

Step (3): (1S,3S,4S)-3-[[(Z,1S)-4-ethoxy-3-fluoro-4-oxo-1-[[(3S)-2-oxo Pyrrolidin-3-yl]methyl]but-2-enyl]carbamoyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-2-carboxylic acid third Butyl ester

To (1 S ,3 S ,4 S )-2-tert-butoxycarbonyl-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxylic acid (202mg, 0.7mmol ) and ethyl (Z,4S)-4-amino-2-fluoro-5-[(3S)-2-oxopyrrolidin-3-yl]pent-2-enoate hydrochloride (195mg, 0.7 mmol) in CH ₂ Cl ₂ /THF (1:1 mixture, 4 mL) was added HOBt monohydrate (213 mg, 1.4 mmol), followed by EDC hydrochloride (173 mg, 0.9 mmol) and DIPEA (485 μL, 2.8 mmol). The reaction mixture was stirred at room temperature for 16 hours. _H2O (15 mL) and aqueous brine solution (15 mL) were added to the reaction mixture. The aqueous phase was extracted with EtOAc (3 x 60 mL). The combined organic phases were dried over anhydrous sodium sulfate, filtered and concentrated under vacuum. The crude residue was purified by normal phase SiO ₂ column chromatography (0-10% MeOH/CH ₂ Cl ₂ ) to afford (1S,3S,4S)-3-[[(Z,1S)-4-ethoxy Base-3-fluoro-4-oxo-1-[[(3S)-2-oxopyrrolidin-3-yl]methyl]but-2-enyl]carbamoyl]-5,5 - tert-butyl difluoro-2-azabicyclo[2.2.2]octane-2-carboxylate as a colorless oil (285mg, yield 79.3%, observed m/z: 518[M+H] ⁺ ).

Step (4): (Z,4S)-4-[[(1S,3S,4S)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carbonyl]amino] -2-Fluoro-5-[(3S)-2-oxopyrrolidin-3-yl]pent-2-enoic acid ethyl ester

烷溶液，1mL，4mmol)。將反應混合物在室溫下攪拌1小時，並在真空中濃縮，以提供(Z,4S)-4-[[(1S,3S,4S)-5,5-二氟-2-氮雜雙環[2.2.2]辛烷-3-羰基]胺基]-2-氟-5-[(3S)-2-氧代吡咯啶-3-基]戊-2-烯酸乙酯的鹽酸鹽，為白色固體(250mg，產率100.0%，觀察到m/z：418[M+H]⁺)，其無需進一步純化即可用於下一步。 To (1S,3S,4S)-3-[[(Z,1S)-4-ethoxy-3-fluoro-4-oxo-1-[[(3S)-2-oxopyrrolidine- 3-yl]methyl]but-2-enyl]carbamoyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-2-carboxylic acid tert-butyl ester (285mg , 0.55 mmol) in CH ₂ Cl ₂ (1 mL) was added hydrochloric acid (4M di

alkane solution, 1 mL, 4 mmol). The reaction mixture was stirred at room temperature for 1 hour and concentrated in vacuo to provide (Z,4S)-4-[[(1S,3S,4S)-5,5-difluoro-2-azabicyclo[ 2.2.2] Octane-3-carbonyl]amino]-2-fluoro-5-[(3S)-2-oxopyrrolidin-3-yl]pent-2-enoic acid ethyl ester hydrochloride, It was a white solid (250 mg, yield 100.0%, observed m/z: 418 [M+H] ⁺ ), which was used in the next step without further purification.

Step (5): (Z,4S)-4-[[(1S,3S,4S)-2-[(2R)-2-(3-Chloroanilino)-4-methyl-pentyl]- 5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-carbonyl]amino]-2-fluoro-5-[(3S)-2- Oxypyrrolidin-3-yl]pent-2-enoic acid ethyl ester

To (Z,4S)-4-[[(1S,3S,4S)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carbonyl]amino]-2-fluoro -5-[(3S)-2-oxopyrrolidin-3-yl]pent-2-enoic acid ethyl ester hydrochloride (40mg, 0.09mmol) and (2 R )-2-(3-chloroanilino )-4-Methyl-valeric acid (21 mg, 0.09 mmol) in DMF (0.5 mL) was added dropwise to DIPEA (62 μL, 0.35 mmol) and HATU (44 mg, 0.11 mmol) in DMF (0.5 mL) solution. The reaction mixture was stirred at room temperature for 30 min and purified by reverse phase HPLC to give (Z,4S)-4-[[(1S,3S,4S)-2-[(2R)-2-(3-chloroanilino )-4-methyl-pentyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carbonyl]amino]-2-fluoro-5-[(3S) -Ethyl 2-oxopyrrolidin-3-yl]pent-2-enoate as a white solid (16 mg, 29% yield, observed m/z: 641 [M+H] ⁺ ). ¹ H NMR (400MHz, CD ₃ OD): δ 7.07(t,1H), 6.73-6.38(m,3H), 5.83(dd,1H), 5.48-5.31(m,1H), 4.58(d,1H) , 4.46-4.38(m,1H), 4.38-4.08(m,3H), 3.20-2.96(m,2H), 2.67(q,1H), 2.48(s,1H), 2.34-1.21(m,16H) , 0.99 (dd,6H).

Example 85: (Z,4S)-4-[[(1S,3S,4S)-2-[(2R)-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl )amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carbonyl]amino]-2-fluoro-5-[(3S)-2- Oxypyrrolidin-3-yl]pent-2-enoic acid ethyl ester (compound 93)

Step (1): (Z,4S)-4-[[(1S,3S,4S)-2-[(2R)-2-(tert-butoxycarbonylamino)-3-cyclobutyl-propane Acyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carbonyl]amino]-2-fluoro- 5-[(3S)-2-Oxopyrrolidin-3-yl]pent-2-enoic acid ethyl ester

To (Z,4S)-4-[[(1S,3S,4S)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carbonyl]amino]-2-fluoro -5-[(3S)-2-oxopyrrolidin-3-yl]pent-2-enoic acid ethyl ester hydrochloride (50mg, 0.11mmol) and (2 R )-2-(tert-butoxy To a solution of carbonylamino)-3-cyclobutyl-propionic acid (27 mg, 0.11 mmol) in DMF (1 mL) was added DIPEA (77 μL, 0.44 mmol) and HATU (54 mg, 0.14 mmol). The reaction mixture was stirred at room temperature for 30 min, filtered and purified by reverse phase HPLC to give (Z,4S)-4-[[(1S,3S,4S)-2-[(2R)-2-(tert-butyl Oxycarbonylamino)-3-cyclobutyl-propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carbonyl]amino]-2-fluoro- Ethyl 5-[(3S)-2-oxopyrrolidin-3-yl]pent-2-enoate as a colorless oil (28 mg, 39% yield, observed m/z: 643 [M+H] ⁺ ).

Step (2): (Z,4S)-4-[[(1S,3S,4S)-2-[(2R)-2-Amino-3-cyclobutyl-propionyl]-5,5- Difluoro-2-azabicyclo[2.2.2]octane-3-carbonyl]amino]-2-fluoro-5-[(3S)-2-oxopyrrolidin-3-yl]pent-2- ethyl acrylate

烷溶液，1mL，4mmol)。將反應混合物在室溫下攪拌30min並在真空下濃縮，以提供 (Z,4S)-4-[[(1S,3S,4S)-2-[(2R)-2-胺基-3-環丁基-丙醯基]-5,5-二氟-2-氮雜雙環[2.2.2]辛烷-3-羰基]胺基]-2-氟-5-[(3S)-2-氧代吡咯啶-3-基]戊-2-烯酸乙酯的鹽酸鹽，為白色固體(定量獲得25mg，觀察到m/z：543[M+H]⁺)，其無需進一步純化即可用於下一步。 To (Z,4S)-4-[[(1S,3S,4S)-2-[(2R)-2-(3-butoxycarbonylamino)-3-cyclobutyl-propionyl]- 5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-carbonyl]amino]-2-fluoro-5-[(3S)-2-oxopyrrolidin-3-yl] A solution of ethyl pent-2-enoate (28 mg, 0.04 mmol) in CH ₂ Cl ₂ (1 mL) was added to hydrochloric acid (4M di

alkane solution, 1 mL, 4 mmol). The reaction mixture was stirred at room temperature for 30 min and concentrated under vacuum to provide (Z,4S)-4-[[(1S,3S,4S)-2-[(2R)-2-amino-3-cyclo Butyl-propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carbonyl]amino]-2-fluoro-5-[(3S)-2-oxo Ethylpyrrolidin-3-yl]pent-2-enoate hydrochloride as a white solid (25 mg obtained quantitatively, observed m/z: 543 [M+H] ⁺ ), which was used without further purification in the next step.

Step (3): (Z,4S)-4-[[(1S,3S,4S)-2-[(2R)-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl Base)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carbonyl]amino]-2-fluoro-5-[(3S)-2 -Oxopyrrolidin-3-yl]pent-2-enoic acid ethyl ester

To (Z,4S)-4-[[(1S,3S,4S)-2-[(2R)-2-amino-3-cyclobutyl-propionyl]-5,5-difluoro-2 -Azabicyclo[2.2.2]octane-3-carbonyl]amino]-2-fluoro-5-[(3S)-2-oxopyrrolidin-3-yl]pent-2-enoic acid ethyl ester To a solution of hydrochloride (25 mg, 0.04 mmol) in MeOH (1 mL) was added ethyl trifluoroacetate (51 μL, 0.43 mmol) and DIPEA (23 μL, 0.13 mmol). The reaction mixture was stirred at room temperature for 30 min. Saturated aqueous sodium bicarbonate (10 mL) was added to the reaction mixture and the aqueous phase was extracted with EtOAc (3 x 15 mL). The combined organic phases were dried over anhydrous sodium sulfate, filtered and concentrated under vacuum. The crude residue was purified by reverse phase HPLC to give (Z,4S)-4-[[(1S,3S,4S)-2-[(2R)-3-cyclobutyl-2-[(2,2,2 -Trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carbonyl]amino]-2-fluoro-5-[ Ethyl (3S)-2-oxopyrrolidin-3-yl]pent-2-enoate as a white solid (11 mg, 41% yield, observed m/z: 639 [M+H] ⁺ ). ¹ H NMR (400MHz, CD ₃ OD): δ 5.97-5.68(m,1H), 5.51-5.31(m,1H), 4.81-4.68(m,1H), 4.43(d,1H), 4.38-4.23( m, 4H), 3.37-3.33 (m, 1H), 2.82-1.47 (m, 21H), 1.35 (t, 3H).

Example 86: (1 S ,3 S ,4 S )-2-((3-chloro-2-methylphenyl)glycyl)-5,5-difluoro-N- (( S , E )-4-fluoro-4-(methylsulfonyl)-1-(( S )-2-oxopyrrolidin-3-yl)but-3-en-2-yl)- 2-Azabicyclo[2.2.2]octane-3-carboxamide (compound 94)

Step (1): Methyl 2-(3-chloro-2-methyl-aniline)acetate

A mixture of 3-chloro-2-methylaniline (1.7 mL, 14.1 mmol), methyl bromoacetate (1.5 mL, 15.7 mmol) and DIEA (3.7 mL, 21.2 mmol) in DMF (20 mL) was degassed with nitrogen. gas. The mixture was stirred at 90° C. for 12 hours under a nitrogen atmosphere. The mixture was diluted with EtOAc (150 mL), washed with water (30 mL) and brine solution (50 mL). The combined organic phases were dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. Purification of the residue by normal phase _SiO2 chromatography (0-30% EtOAc/petroleum ether) gave methyl 2-(3-chloro-2-methyl-aniline)acetate as a yellow solid (2.4 g, yield 62%, 78% purity, observed m/z: 214 [M+H] ⁺ ). ¹ H NMR (400MHz, CD ₃ OD): δ 6.97(t,1H), 6.72(d,1H), 6.70(d,1H), 3.99(s,2H), 3.71(s,3H), 2.24(s ,3H).

Step (2): 2-(3-Chloro-2-methyl-aniline)acetic acid

To a solution of methyl 2-(3-chloro-2-methyl-aniline)acetate (1.0 g, 4.7 mmol) in methanol (8 mL) was added lithium hydroxide monohydrate (393 mg, 9.4 mmol) and water (2 mL ). The mixture was stirred at room temperature for 12 hours. The reaction mixture was concentrated and aqueous HCl (0.5N) was added to adjust the pH to 1. The mixture was filtered and the white solid was collected and dried to give 2-(3-chloro-2-methyl-aniline)acetic acid as a yellow solid which was used in the next step without further purification (0.9 g, 96% yield); observation to m/z: 200[M+H] ⁺ ). ¹ H NMR (400 MHz, CD ₃ OD): δ 6.98 (t, 1H), 6.70 (d, 1H), 6.40 (d, 1H), 3.93 (s, 2H), 2.24 (s, 3H).

Step (3): (1S,3S,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((S,E)- 4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2 .2] Octane-3-carboxamide

To (1 S ,3 S ,4 S )-5,5-difluoro- N -(( S ,E)-4-fluoro-4-(methylsulfonyl)-1-(( S )-2 -Oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide hydrochloride (45 mg, 98 μmol) in DMF ( 1 mL) was added HATU (48 mg, 0.13 mmol), DIEA (85 μL, 0.49 mmol) and 2-(3-chloro-2-methyl-aniline)acetic acid (20 mg, 0.098 mmol). The mixture was stirred at room temperature for 1 hour. The reaction mixture was diluted with EtOAc (10 mL) and washed with water (10 mL). The organic layer was washed with brine solution (5 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. Purification of the residue by reverse-phase HPLC gave ( 1S , 3S , 4S )-2-((3-chloro-2-methylphenyl)glycinyl)-5,5-difluoro- N- (( S , E )-4-fluoro-4-(methylsulfonyl)-1-(( S )-2-oxopyrrolidin-3-yl)but-3-en-2-yl)- 2-Azabicyclo[2.2.2]octane-3-carboxamide as a white solid (27 mg, 41 % yield, observed m/z: 605 [M+H] ⁺ ). ¹ H NMR (400MHz, CD ₃ OD): δ 7.18-7.09(m,1H), 7.07-6.92(m,1H), 6.88-6.73(m,1H), 6.23-6.08(m,1H), 4.99- 4.90(m,2H), 4.33(s,1H), 4.30-4.18(m,2H), 3.31-3.19(m,2H), 3.16-3.10(m,3H), 2.72-2.57(m,2H), 2.51-2.35(m,2H), 2.33(s,3H), 2.30-2.11(m,3H), 1.93-1.73(m,4H), 1.66-160(m,1H).

Example 87: (1 S ,3 S ,4 S )-2-((3-chlorophenyl)glycinyl)-5,5-difluoro-N-(( S , E )-4-fluoro -4-(Methylsulfonyl)-1-(( S )-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2] Octane-3-formamide (compound 95)

Step (1): Methyl 2-(3-chloroanilino)acetate

A mixture of methyl bromoacetate (1.5 mL, 15.7 mmol), 3-chloroaniline (1.7 mL, 15.7 mmol) and potassium carbonate (2.2 g, 15.7 mmol) in DMF (40 mL) was degassed with nitrogen. The mixture was stirred at room temperature for 12 hours. The reaction mixture was partitioned between water (200 mL) and EtOAc (50 mL). The organic phase was separated, washed with brine solution (50 mL), dried over anhydrous sodium sulfate, filtered and concentrated. Purification of the residue by normal phase _SiO2 chromatography (0-10% EtOAc/petroleum ether) afforded methyl 2-(3-chloroanilino)acetate as a white solid (1.4 g, 43% yield, observed m/z: 200[M+H] ⁺ ). ¹ H NMR (400MHz, CDCl ₃ ): δ 7.03(t,1H), 6.65(d,1H), 6.51-6.49(m,1H), 6.43-6.40(m,1H), 3.83(s,2H), 3.73(s,3H).

Step (2): 2-(3-Chloroanilino)acetic acid

To a solution of methyl 2-(3-chloroanilino)acetate (0.7 g, 3.5 mmol) in THF (18 mL) was added lithium hydroxide monohydrate (912 mg, 21.7 mmol) and water (3.5 mL). The mixture was stirred at room temperature for 1 hour. The residue was diluted with H ₂ O (50 mL), aqueous HCl (1 N) was added to adjust the pH to 3 and extracted with ethyl acetate (50 mL×2). The combined organic phases were washed with brine solution (50 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 2-(3-chloroanilino)acetic acid as a yellow solid which was used without further purification In the next step (0.66 g, 91% yield, observed m/z: 186 [M+H] ⁺ ).

Step (3): (1S,3S,4S)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((S,E)-4-fluoro-4 -(Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide

To (1 S ,3 S ,4 S )-5,5-difluoro- N -(( S , E )-4-fluoro-4-(methylsulfonyl)-1-(( S )-2 -Oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide hydrochloride (78mg, 0.17mol) and 2 To a solution of -(3-chloroanilino)acetic acid (31 mg, 0.17 mmol) in DMF (2 mL) was added HATU (84 mg, 0.22 mol) and DIEA (148 μL, 0.85 mmol). The mixture was stirred at room temperature for 1 hour. The reaction mixture was diluted with EtOAc (50 mL) and washed with brine solution (3 x 50 mL). The combined organic phases were dried over anhydrous sodium sulfate, filtered and concentrated. Purification of the residue by reverse-phase HPLC gave ( 1S , 3S , 4S )-2-((3-chlorophenyl)glycinyl)-5,5-difluoro- N -(( S , E )-4-fluoro-4-(methylsulfonyl)-1-(( S )-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo [2.2.2] Octane-3-formamide, as a white solid (16 mg, yield 15%, observed m/z: 591 [M+H] ⁺ ); ¹ H NMR (400MHz, CD ₃ OD) : δ 7.25-7.15(m,1H), 7.10-6.75(m,3H), 6.10-5.95(m,1H), 4.86-4.79(m,1H), 4.44(s,1H), 4.28-4.06(m ,3H), 3.21(td,2H), 3.20-3.10(m,2H), 3.02(s,3H), 2.60-2.44(m,2H), 2.41-2.21(m,2H), 2.19-1.97(m ,3H), 1.79-1.58(m,4H), 1.57-1.46(m,1H).

Example 88: 8-(4-Fluoro- 1H -indole-2-carbonyl) -N -[( 1S )-3-fluoro-2-oxo-1-[[( 3S )-2 -Oxopyrrolidin-3-yl]methyl]propyl]-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide (compounds 96 and 97)

Step (1): Methyl 8-(4-fluoro-1H-indole-2-carbonyl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxylate

To 5-oxa-8-azaspiro[3.5]nonane-9-carboxylic acid methyl ester hydrochloride (141mg, 0.64mmol), 4-fluoro- 1H -indole-2-carboxylic acid (114mg, 0.64 mmol) and HATU (363 mg, 0.95 mmol) in NMP (3.2 mL) was added DIPEA (333 μL, 1.9 mmol). The reaction mixture was stirred at room temperature for 3 hours. Aqueous HCl (1 N, 3 mL) and water (3 mL) were added to the reaction mixture. The mixture was extracted 3 times with EtOAc (3 x 20 mL). The combined organic phase salts were washed with aqueous solution (2x), dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. Purification of the crude residue by normal phase SiO _column chromatography (25-100% EtOAc/hexanes) afforded 8-(4-fluoro-1H-indole-2-carbonyl)-5-oxa-8- Methyl azaspiro[3.5]nonane-9-carboxylate as a white solid (175 mg, 80% yield, observed m/z: 347 [M+H] ⁺ ).

Step (2): 8-(4-fluoro-1H-indole-2-carbonyl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxylic acid

To 8-(4-fluoro-1H-indole-2-carbonyl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxylic acid methyl ester (175mg, 0.51mmol) in THF (2.5 mL) was added LiOH (IN in water, 556 μL, 0.56 mmol). The reaction mixture was stirred at room temperature for 30 minutes. Water was added to the reaction mixture followed by HCl (1 N in water) until pH 2 was reached. The mixture was extracted with EtOAc (3 x 15 mL). The combined organic phases were dried over anhydrous sodium sulfate, filtered, and concentrated in vacuo to give 8-(4-fluoro- 1H -indole-2-carbonyl)-5-oxa-8-azaspiro[ 3.5] Nonane-9-carboxylic acid as a white foam (181 mg obtained quantitatively, observed m/z: 333 [M+H] ⁺ ), which was used in the next step without further purification.

Step (3): (3S)-3-[(2S)-2-Amino-4-fluoro-3-oxo-butyl]pyrrolidin-2-one

烷溶液，694μL，2.8mmol)。將反應混合物在室溫下攪拌15分鐘。向該混合物加入MeOH(0.1mL)。將反應混合物在室溫下攪拌1.5小時，並在真空下濃縮，以提供(3S)-3-[(2S)-2-胺基-4-氟-3-側氧基-丁基]吡咯啶-2-酮的鹽酸鹽，為白色泡沫(定量獲得130mg，觀察到m/z：389[M+H]⁺)，其無需進一步純化即可用於下一步。 To N-[(1S)-3-fluoro-2-oxo-1-[[(3S)-2-oxopyrrolidin-3-yl]methyl]propyl]carbamate tertiary butyl ester (200 mg, 0.69 mmol; prepared according to the procedure described in International Application No. PCT/CN2021/076400, which is incorporated herein by reference in its entirety) in CH ₂ Cl ₂ (3.5 mL) was added dropwise in HCl (4N 1,4-di

alkane solution, 694 μL, 2.8 mmol). The reaction mixture was stirred at room temperature for 15 minutes. To this mixture was added MeOH (0.1 mL). The reaction mixture was stirred at room temperature for 1.5 hours and concentrated in vacuo to afford ( 3S )-3-[( 2S )-2-amino-4-fluoro-3-oxo-butyl] The hydrochloride salt of pyrrolidin-2-one as a white foam (130 mg quantified, observed m/z: 389 [M+H] ⁺ ) was used in the next step without further purification.

Step (4): 8-(4-fluoro-1H-indole-2-carbonyl)-N-[(1S)-3-fluoro-2-oxo-1-[[(3S)- 2-oxopyrrolidin-3-yl]methyl]propyl]-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide

To 8-(4-fluoro- 1H -indole-2-carbonyl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxylic acid (60mg, 0.18mmol) and (3 S ) -3-[( 2S )-2-amino-4-fluoro-3-oxo-butyl]pyrrolidin-2-one hydrochloride (48 mg, 0.21 mmol) in CH ₂ Cl ₂ (0.9 mL ) and THF (0.9 mL) was added DCC (74 mg, 0.36 mmol). The reaction mixture was stirred at room temperature for 2 hours. To this mixture was added DMA (0.39 mL). The reaction mixture was stirred at room temperature for 21 hours, and then filtered. The filtrate was concentrated in vacuo. The crude residue was purified first by normal phase SiO ₂ column chromatography (0-10% MeOH/CH ₂ Cl ₂ ) and then by reverse phase preparative HPLC to afford the separated diastereoisomers.

Minor diastereomer (compound 96) : (faster eluting diastereomer, single diastereomer I): (1.2 mg, 1% yield, observed m/z : 503[M+H] ⁺ ); ¹ H NMR (400MHz, CD ₃ OD): δ 8.55(d,1H), 7.32-7.23(m,1H), 7.19(td,1H), 6.97(s,1H ), 6.76(dd,1H), 5.19-5.07(m,1H), 4.56-4.36(m,1H), 4.35-4.15(m,2H), 4.02(s,1H), 3.82(d,2H), 2.60-2.26 (m, 4H), 2.27-1.99 (m, 5H), 1.99-1.63 (m, 4H).

Minor diastereomer (compound 97) : (slower eluting diastereomer, single diastereomer II): (1.9 mg, 2% yield, observed m/z : 503[M+H] ⁺ ); ¹ H NMR (400MHz, CD ₃ OD): δ 7.27(d,1H), 7.23-7.12(m,1H), 6.98(s,1H), 6.76(dd,1H ), 5.31-5.02(m,2H), 4.57-4.34(m,1H), 4.33-4.15(m,2H), 3.84(d,2H), 3.41-3.21(m,2H), 2.60-2.30(m ,4H), 2.28-1.97(m,5H), 1.97-1.64(m,5H).

Example 89: 8-(7-Chloro- 1H -indole-2-carbonyl) -N -[( 1S )-3-fluoro-2-oxo-1-[[( 3S )-2 -Oxopyrrolidin-3-yl]methyl]propyl]-5-oxa-8-azaspiro[3.5]nonane-9- Formamide (Compounds 98 and 99)

By coupling ( 3S )-3-[( 2S )-2-amino-4-fluoro-3-oxo-butyl]pyrrolidin-2-one hydrochloride with an appropriate carboxylic acid to About 8-(4-fluoro-1 H -indole-2-carbonyl) -N -[(1 S )-3-fluoro-2-oxo-1-[[(3 S )-2-oxo 8-(7-chloro-1 H -indole-2-carbonyl) -N -[(1 S )-3-fluoro-2-oxo-1-[[(3 S )-2-oxopyrrolidin-3-yl]methyl ]propyl]-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide to obtain 8-(7-chloro- 1H -indole-2-carbonyl) -N- [ (1 S )-3-fluoro-2-oxo-1-[[(3 S )-2-oxopyrrolidin-3-yl]methyl]propyl]-5-oxa-8-nitrogen Isolated diastereoisomers of heterospiro[3.5]nonane-9-carboxamide.

Major diastereomer (compound 98) : (single diastereomer I, faster eluting diastereomer): (3.7 mg, 5% yield, observed m/z: 519[M+H] ⁺ ); ¹ H NMR (400MHz, CD ₃ OD): δ 7.68-7.52 (m, 1H), 7.33-7.22 (m, 1H), 7.14-7.02 (m, 1H), 6.97 ( s,1H), 5.37-5.04(m,2H), 4.59-4.22(m,2H), 4.14(s,1H), 3.81(s,2H), 3.41-3.22(m,3H), 2.62-2.27( m, 3H), 2.27-2.12 (m, 3H), 2.12-1.97 (m, 1H), 1.97-1.61 (m, 4H).

Minor diastereomer (compound 99) : (single diastereomer II, slower eluting diastereomer): (1.6 mg, 2% yield, observed m/z : 519[M+H] ⁺ ); ¹ H NMR (400MHz, CD ₃ OD): δ 7.68-7.52(m, 1H), 7.27(ddd, 1H), 7.11-7.02(m, 1H), 6.97(s ,1H), 5.36-5.04(m,2H), 4.57-4.08(m,3H), 3.82(s,2H), 3.41-3.21(m,1H), 2.61-2.28(m,4H), 2.28-2.13 (m,3H), 2.13-2.00(m,2H), 1.99-1.65(m,4H).

Example 90: (1 S ,3 S ,4 S )-2-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-5,5-difluoro- N -(( S )-4-fluoro-3-oxo-1-(( S )-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabis Cyclo[2.2.2]octane-3-carboxamide (compound 100)

By coupling ( 3S )-3-[( 2S )-2-amino-4-fluoro-3-oxo-butyl]pyrrolidin-2-one hydrochloride with an appropriate carboxylic acid to Regarding 8-(7-chloro-1 H -indole-2-carbonyl) -N -[(1 S )-3-fluoro-2-oxo-1-[[(3 S )-2-oxo Pyrrolidin-3-yl]methyl]propyl]-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide was prepared in a similar manner as described (1 S , 3 S , 4 S )-2-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-5,5-difluoro- N -(( S )-4-fluoro-3-oxo -1-(( S )-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide; observed m/ z: 550[M+H] ⁺ ; ¹ H NMR (400MHz, CD ₃ OD): δ 7.67(q, 1H), 7.61-7.52(m, 3H), 5.24-5.01(m, 2H), 4.33-4.29 (m,1H), 4.21-4.08(m,1H), 3.83-3.74(m,1H), 3.62-3.54(m,2H), 3.29-3.09(m,2H), 2.83-2.76(m,1H) , 2.68-2.54 (m, 2H), 2.36-2.30 (m, 1H), 1.85-1.68 (m, 6H), 1.33 (s, 1H).

Example 91: (1 S ,3a R ,6a S )-2-(2-(3-chlorophenyl)-2,2-difluoroacetyl) -N -(( S )-4-fluoro- 3-oxo-1-(( S )-2-oxopyrrolidin-3-yl)butane-2-yl)octahydrocyclopenta[ c ]pyrrole-1-carboxamide (compound 101)

By coupling ( 3S )-3-[( 2S )-2-amino-4-fluoro-3-oxo-butyl]pyrrolidin-2-one hydrochloride with an appropriate carboxylic acid to Regarding 8-(7-chloro-1 H -indole-2-carbonyl) -N -[(1 S )-3-fluoro-2-oxo-1-[[(3 S )-2-oxo Pyrrolidin-3-yl]methyl]propyl]-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide was prepared in a similar manner as described (1 S , 3a R , 6a S )-2-(2-(3-chlorophenyl)-2,2-difluoroacetyl) -N -(( S )-4-fluoro-3-oxo-1-(( S ) -2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[ c ]pyrrole-1-carboxamide; observed m/z: 514[M+H] ⁺ ; ¹ H NMR (400MHz, CD ₃ OD): δ 7.62-7.47(m,4H), 5.24-4.98(m,1H), 4.71(dd,1H), 4.44-4.13(m,2H), 3.74(dd,1H) , 3.51(d,1H), 3.29-3.12(m,2H), 2.78-2.70(m,1H), 2.70-2.55(m,2H), 2.35-229(m,1H), 2.15(s,1H) , 2.12-2.00 (m, 1H), 1.98-1.92 (m, 1H), 1.89-1.77 (m, 2H), 1.75-1.63 (m, 3H), 1.32-1.24 (m, 1H).

Example 92: (1 S ,3a R ,6a S )-2-(2,2-difluoro-2-(3-fluorophenyl)acetyl) -N -(( S )-4-fluoro- 3-oxo-1-(( S )-2-oxopyrrolidin-3-yl)butane-2-yl)octahydrocyclopenta[ c ]pyrrole-1-carboxamide (compound 102)

By adding (1 S ,3a R ,6a S )-2-(2,2-difluoro-2-(3-fluorophenyl)acetyl) -N -(( S )-4-fluoro-3- Oxy-1-(( S )-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[ c ]pyrrole-1-carboxamide is coupled with an appropriate carboxylic acid to With respect to 8-(7-chloro-1 H -indole-2-carbonyl) -N -[(1 S )-3-fluoro-2-oxo-1-[[(3 S )-2-oxo Pyrrolidin-3-yl]methyl]propyl]-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide was prepared in a manner similar to that described for (1 S , 3a R , 6a S )-2-(2-(3-chlorophenyl)-2,2-difluoroacetyl) -N -(( S )-4-fluoro-3-oxo-1-(( S )-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[ c ]pyrrole-1-carboxamide; observed m/z: 498[M+H] ⁺ ; ¹ H NMR (400MHz, CD ₃ OD): δ 7.67(q,1H), 7.61-7.52(m,3H), 5.24-5.01(m,2H), 4.33-4.29(m,1H), 4.21-4.08(m ,1H), 3.83-3.74(m,1H), 3.62-3.54(m,2H), 3.29-3.09(m,2H), 2.79(ddd,1H), 2.63(dtd,2H), 2.32(ddt,1H ), 2.04-1.97(m,2H), 1.87-1.82(m,2H), 1.75-1.67(m,3H), 1.33(s,1H).

Example 93: (1 S ,3a R ,6a S )-2-(2-fluoro-2-(3-fluorophenyl)propionyl) -N -(( S )-4-fluoro-3-side Oxy-1-(( S )-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[ c ]pyrrole-1-carboxamide (Compounds 103 and 104)

By adding (1 S ,3a R ,6a S )-2-(2,2-difluoro-2-(3-fluorophenyl)acetyl) -N -(( S )-4-fluoro-3- Oxy-1-(( S )-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[ c ]pyrrole-1-carboxamide is coupled with an appropriate carboxylic acid to With respect to 8-(7-chloro-1 H -indole-2-carbonyl) -N -[(1 S )-3-fluoro-2-oxo-1-[[(3 S )-2-oxo Pyrrolidin-3-yl]methyl]propyl]-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide was prepared in a manner similar to that described for (1 S , 3a R , 6a S )-2-(2-fluoro-2-(3-fluorophenyl) propionyl) -N -(( S )-4-fluoro-3-side oxy-1-(( S )-2 -oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[ c ]pyrrole-1-carboxamide (mixture of diastereoisomers). (1 S , 3a R , 6a S )-2-(2-fluoro-2-(3-fluorophenyl)propionyl) -N -(( S )-4-fluoro-3- Oxy-1-(( S )-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[ c ]pyrrole-1-carboxamide (diastereoisomer mixture, 25mg).

Minor diastereomer (compound 103) : (single diastereomer I, faster eluting diastereomer): (5.1 mg, 10% yield, observed m/z : 494[M+H] ⁺ ); ¹ H NMR (400MHz, CD ₃ OD): δ 7.44(d, 1H), 7.27-7.04(m, 3H), 5.23-5.00(m, 1H), 4.71(s ,1H), 4.28(s,2H), 3.91-3.32(m,4H), 2.73-2.31(m,4H), 2.02-1.35(m,11H), 0.76(s,1H).

Major diastereomer (compound 104) : (single diastereomer II, slower eluting diastereomer): (5.6 mg, 11% yield, observed m/z: 494[M+H] ⁺ ); ¹ H NMR (400MHz, CD ₃ OD): δ 7.43(t,1H), 7.28-7.05(m,3H), 5.23-5.00(m,1H), 4.69(d, 1H), 4.30(d,1H), 4.25-4.11(m,1H), 3.85(s,1H), 3.57(s,1H), 3.37(d,2H), 2.72-2.49(m,4H), 2.40 -2.32(m,1H), 1.91-1.79(m,4H), 1.77-1.72(m,2H), 1.70-1.59(s,2H), 1.51(q,1H), 1.46-1.36(m,1H) , 0.82-0.70 (m, 1H).

Example 94: (1 S ,3 S ,4 S )-5,5-difluoro-2-(4-methoxy-1 H -indole-2-carbonyl) -N -[(1 S ,2 E )-1-[[( 3S )-2-oxopyrrolidin-3-yl]methyl]-2-(2-oxotetrahydrofuran-3-ylidene)ethyl]-2-aza Bicyclo[2.2.2]octane-3-carboxamide (compound 105)

Step (1): ((S)-1-(2-oxodihydrofuran-3(2H)-ylidene)-3-((S)-2-oxopyrrolidin-3-yl)propane -2-yl) tertiary butyl carbamate (cis/trans isomer)

tertiary butyl N-[(1S)-1-formyl-2-[(3S)-2-oxopyrrolidin-3-yl]ethyl]carbamate (115 mg, 0.45 mmol) and 3-diethoxyphosphoryltetrahydrofuran-2-one (100mg, 0.45mmol) in THF (0.9mL) were added portionwise to a suspension of potassium carbonate (10M in H ₂ O, 135 μL, 1.35 mmol). The reaction mixture was stirred for 22 hours, gradually warming to room temperature. Water (20 mL) was added to the reaction mixture. The _mixture was extracted with diethyl ether (3 x 15 mL), then _CH2Cl2 (3 x 15 mL). The combined organics were washed with aqueous brine solution (15 mL), dried over anhydrous sodium sulfate, filtered, and concentrated in vacuo. The crude residue was purified by normal phase _SiO2 column chromatography (40-60% acetone/ _CH2Cl2 ) to afford N-[(1S, _2E )-2-(2-oxotetrahydrofuran-3-ylidene base)-1-[[(3S)-2-oxopyrrolidin-3-yl]methyl]ethyl]carbamate as a white solid (41 mg, yield 28%, observed m /z: 225[M-Boc] ⁺ ) and N-[(1S,2Z)-2-(2-oxotetrahydrofuran-3-yl subunit)-1-[[(3S)-2-oxopyrrole tert-butylpyridin-3-yl]methyl]ethyl]carbamate as a white solid (52 mg, 36% yield, observed m/z: 225 [M-Boc] ⁺ ).

Step (2): (3S)-3-[(2S,3E)-2-Amino-3-(2-oxotetrahydrofuran-3-ylidene)propyl]pyrrolidin-2-one

烷溶液，128μL，0.51mmol)。將反應混合物在室溫下攪拌15分鐘。向該混合物加入MeOH(0.1mL)。將反應混合物在室溫下攪拌22小時，並在真空下濃縮，以提供(3S)-3-[(2S,3E)-2-胺基-3-(2-氧代四氫呋喃-3-基亞基)丙基]吡咯啶-2-酮的鹽酸鹽，為白色泡沫(定量獲得33mg，觀察到m/z：225[M+H]⁺)，其無需進一步純化即可用於下一步。 To N-[(1S,2E)-2-(2-oxotetrahydrofuran-3-yl subunit)-1-[[(3S)-2-oxopyrrolidin-3-yl]methyl]ethyl ] A solution of tert-butyl carbamate (41 mg, 0.13 mmol) in CH ₂ Cl ₂ (0.65 mL) was added dropwise to hydrochloric acid (4N 1,4-di

alkane solution, 128 μL, 0.51 mmol). The reaction mixture was stirred at room temperature for 15 minutes. To this mixture was added MeOH (0.1 mL). The reaction mixture was stirred at room temperature for 22 hours and concentrated in vacuo to provide ( 3S )-3-[( 2S , 3E )-2-amino-3-(2-oxotetrahydrofuran-3 -Yylidene)propyl]pyrrolidin-2-one hydrochloride as a white foam (33 mg obtained quantitatively, observed m/z: 225 [M+H] ⁺ ), which was used without further purification in the following step.

Step (3): (1S,3S,4S)-5,5-Difluoro-3-[[(1S,2E)-1-[[(3S)-2-oxopyrrolidin-3-yl]methanol Base]-2-(2-oxotetrahydrofuran-3-ylidene)ethyl]aminoformyl]-2-azabicyclo[2.2.2]octane-2-carboxylic acid tert-butyl ester

To (3 S )-3-[(2 S ,3 E )-2-amino-3-(2-oxotetrahydrofuran-3-ylidene)propyl]pyrrolidin-2-one at 0°C Hydrochloride (33 mg, 0.13 mmol), (1 S ,3 S ,4 S )-2-tert-butoxycarbonyl-5,5-difluoro-2-azabicyclo[2.2.2]octane- To a solution of 3-carboxylic acid (31 mg, 0.10 mmol) and EDC (36 mg, 0.19 mmol) in DMA (1.1 mL) was added DMAP (38 mg, 0.32 mmol). The reaction mixture was stirred at 0 °C for 2 hours. To this mixture was added DIPEA (18 μL, 0.10 mmol) and after 3 hours further DIPEA (18 μL, 0.10 mmol) was added. The reaction was stirred for 20 hours, gradually warming to room temperature. Hydrochloric acid (1N in water, 5 mL) and water (5 mL) were added to the reaction mixture. The mixture was extracted with EtOAc (3 x 15 mL). The combined organic phases were washed with aqueous brine solution (3 x 10 mL), dried over anhydrous sodium sulfate, filtered, and concentrated in vacuo. The crude residue was purified by normal phase SiO ₂ column chromatography (2-10% MeOH/CH ₂ Cl ₂ ) to afford (1S,3S,4S)-5,5-difluoro-3-[[(1S, 2E)-1-[[(3S)-2-oxopyrrolidin-3-yl]methyl]-2-(2-oxotetrahydrofuran-3-ylidene)ethyl]carbamoyl]- Tert-butyl 2-azabicyclo[2.2.2]octane-2-carboxylate as a white solid (12 mg, 23% yield, observed m/z: 498 [M+H] ⁺ ).

Step (4): (1S,3S,4S)-5,5-Difluoro-N-[(1S,2E)-1-[[(3S)-2-oxopyrrolidin-3-yl]methyl ]-2-(2-oxotetrahydrofuran-3-ylidene)ethyl]-2-azabicyclo[2.2.2]octane-3-carboxamide hydrochloride

烷溶液，24μL，0.9mmol)。將反應混合物在室溫下攪拌15分鐘。向該混合物加入MeOH(0.1mL)。將反應混合物在室溫下攪拌28小時並在真空下濃縮，以提供(1S,3S,4S)-5,5-二氟-N-[(1S,2E)-1-[[(3S)-2-氧代吡咯啶-3-基]甲基]-2-(2-氧代四氫呋喃-3-基亞基)乙基]-2-氮雜雙環[2.2.2]辛烷-3-甲醯胺的鹽酸鹽，為白色泡沫(定量獲得10mg，觀察到m/z：398[M+H]⁺)， 其無需進一步純化即可用於下一步。 To (1S,3S,4S)-5,5-difluoro-3-[[(1S,2E)-1-[[(3S)-2-oxopyrrolidin-3-yl]methyl]-2 -(2-Oxotetrahydrofuran-3-ylidene)ethyl]carbamoyl]-2-azabicyclo[2.2.2]octane-2-carboxylic acid tert-butyl ester (12mg, 0.02mmol) A solution in CH ₂ Cl ₂ (0.47 mL) was added dropwise with hydrochloric acid (4N 1,4-di

alkane solution, 24 μL, 0.9 mmol). The reaction mixture was stirred at room temperature for 15 minutes. To this mixture was added MeOH (0.1 mL). The reaction mixture was stirred at room temperature for 28 hours and concentrated under vacuum to provide ( 1S , 3S , 4S )-5,5-difluoro- N -[( 1S , 2E )-1-[ [(3 S )-2-oxopyrrolidin-3-yl]methyl]-2-(2-oxotetrahydrofuran-3-ylidene)ethyl]-2-azabicyclo[2.2.2] Octane-3-carboxamide hydrochloride as a white foam (10 mg obtained quantitatively, observed m/z: 398 [M+H] ⁺ ), which was used in the next step without further purification.

Step (5): (1S,3S,4S)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-[(1S,2E)-1- [[(3S)-2-oxopyrrolidin-3-yl]methyl]-2-(2-oxotetrahydrofuran-3-ylidene)ethyl]-2-azabicyclo[2.2.2] Octane-3-formamide

To (1 S ,3 S ,4 S )-5,5-difluoro- N -[(1 S ,2 E )-1-[[(3 S )-2-oxopyrrolidin-3-yl] Methyl]-2-(2-oxotetrahydrofuran-3-ylidene)ethyl]-2-azabicyclo[2.2.2]octane-3-carboxamide hydrochloride (10mg, 0.02mmol) , 4-Methoxy- 1H -indole-2-carboxylic acid (3.9mg, 0.02mmol) and HATU (14mg, 0.04mmol) in NMP (0.66mL) was added to NMM (8.7μL, 0.08mmol) . The reaction mixture was stirred at room temperature for 4 hours. To the mixture were added hydrochloric acid (1N in water, 5 mL) and water (5 mL). The mixture was extracted with EtOAc (3 x 10 mL). The combined organics were washed with aqueous brine solution (3 x 10 mL), dried over anhydrous sodium sulfate, filtered, and concentrated in vacuo. Purification of the crude residue by reverse phase HPLC afforded ( 1S , 3S , 4S )-5,5-difluoro-2-(4-methoxy- 1H -indole-2-carbonyl) -N- [(1 S ,2 E )-1-[[(3 S )-2-oxopyrrolidin-3-yl]methyl]-2-(2-oxotetrahydrofuran-3-ylidene)ethyl ]-2-Azabicyclo[2.2.2]octane-3-carboxamide as a white solid (4.8 mg, 43% yield, observed m/z: 571 [M+H] ⁺ ). ¹ H NMR (400MHz, CD ₃ OD): δ 7.18(d,1H), 7.07(d,1H), 7.00-6.76(m,1H), 6.67-6.28(m,2H), 5.30-4.93(m, 2H), 4.75(s,1H), 4.54(s,1H), 4.45-4.16(m,1H), 4.05(s,1H), 4.00-3.80(m,3H), 3.14-2.81(m,2H) , 2.85-2.62 (m, 2H), 2.62-2.27 (m, 4H), 2.27-1.99 (m, 2H), 1.99-1.72 (m, 3H), 1.72-1.22 (m, 2H).

Example 95: (1 S ,3 S ,4 S )-5,5-difluoro-2-(4-methoxy-1 H -indole-2-carbonyl) -N- [(1 S ,2 Z )-1-[[(3 S )-2-oxopyrrolidin-3-yl]methyl]-2-(2-oxotetrahydrofuran-3-ylidene)ethyl ]-2-Azabicyclo[2.2.2]octane-3-carboxamide (compound 106)

Step (1): (3S)-3-[(2S,3Z)-2-Amino-3-(2-oxotetrahydrofuran-3-ylidene)propyl]pyrrolidin-2-one

烷溶液，160μL，0.64mmol)。將反應混合物在室溫下攪拌15分鐘。向該混合物加入MeOH(0.1mL)。將反應混合物在室溫下攪拌3小時並在真空下濃縮，以提供(3S)-3-[(2S,3Z)-2-胺基-3-(2-氧代四氫呋喃-3-基亞基)丙基]吡咯啶-2-酮的鹽酸鹽，為白色泡沫(42mg，觀察到m/z：225[M+H]⁺)，其無需進一步純化即可用於下一步。 To N-[(1S,2Z)-2-(2-oxotetrahydrofuran-3-yl subunit)-1-[[(3S)-2-oxopyrrolidin-3-yl]methyl]ethyl ] A solution of tert-butyl carbamate (52 mg, 0.16 mmol) in CH ₂ Cl ₂ (0.8 mL) was added dropwise to hydrochloric acid (4N 1,4-di

alkane solution, 160 μL, 0.64 mmol). The reaction mixture was stirred at room temperature for 15 minutes. To this mixture was added MeOH (0.1 mL). The reaction mixture was stirred at room temperature for 3 hours and concentrated in vacuo to provide ( 3S )-3-[( 2S , 3Z )-2-amino-3-(2-oxotetrahydrofuran-3- The hydrochloride salt of (ylidene)propyl]pyrrolidin-2-one as a white foam (42 mg, observed m/z: 225 [M+H] ⁺ ) was used in the next step without further purification.

Step (2): (1S,3S,4S)-5,5-Difluoro-3-[[(1S,2Z)-1-[[(3S)-2-oxopyrrolidin-3-yl]methanol Base]-2-(2-oxotetrahydrofuran-3-ylidene)ethyl]aminoformyl]-2-azabicyclo[2.2.2]octane-2-carboxylic acid third butyl salt

To (3 S )-3-[(2 S ,3 Z )-2-amino-3-(2-oxotetrahydrofuran-3-ylidene)propyl]pyrrolidin-2-one at 0°C Hydrochloride (42 mg, 0.16 mmol), (1 S ,3 S ,4 S )-2-tert-butoxycarbonyl-5,5-difluoro-2-azabicyclo[2.2.2]octane- A solution of 3-carboxylic acid (39 mg, 0.13 mmol) and EDC (46 mg, 0.24 mmol) in DMA (1.3 mL) was added with DMAP (49 mg, 0.13 mmol). The mixture was stirred at 0 °C for 2 hours. DIPEA (23 μL, 0.13 mmol) was added to the reaction mixture and another DIPEA (23 μL, 0.13 mmol) was added after 3 hours. The reaction was stirred for 20 hours, gradually warming to room temperature. Hydrochloric acid (1N in water, 5 mL) and water (5 mL) were added to the reaction mixture. The mixture was extracted with EtOAc (3 x 15 mL). The combined organic phases were washed with aqueous brine solution (3 x 10 mL), dried over anhydrous sodium sulfate, filtered, and concentrated in vacuo. The crude residue was purified by normal phase SiO ₂ column chromatography (2-10% MeOH/CH ₂ Cl ₂ ) to afford (1S,3S,4S)-5,5-difluoro-3-[[(1S, 2Z)-1-[[(3S)-2-oxopyrrolidin-3-yl]methyl]-2-(2-oxotetrahydrofuran-3-yllidene)ethyl]aminoformyl]- 2-Azabicyclo[2.2.2]octane-2-carboxylic acid tert-butyl salt as a white solid (27 mg, 40% yield, observed m/z: 498 [M+H] ⁺ ).

Step (3): (1S,3S,4S)-5,5-Difluoro-N-[(1S,2Z)-1-[[(3S)-2-oxopyrrolidin-3-yl]methyl ]-2-(2-Oxotetrahydrofuran-3-ylidene)ethyl]-2-azabicyclo[2.2.2]octane-3-carboxamide

烷溶液，53μL，0.21mmol)。將反應混合物在室溫下攪拌15分鐘。向該混合物加入MeOH(0.1mL)。將反應混合物在室溫下攪拌29小時，並在真空下濃縮，以提供(1S,3S,4S)-5,5-二氟-N-[(1S,2Z)-1-[[(3S)-2-氧代吡咯啶-3-基]甲基]-2-(2-氧代四氫呋喃-3-基亞基)乙基]-2-氮雜雙環[2.2.2]辛烷-3-甲醯胺的鹽酸鹽，為白色泡沫(定量獲得23mg，觀察到m/z：398[M+H]⁺)，其無需進一步純化即可用於下一步。 To (1S,3S,4S)-5,5-difluoro-3-[[(1S,2Z)-1-[[(3S)-2-oxopyrrolidin-3-yl]methyl]-2 -(2-Oxotetrahydrofuran-3-ylidene)ethyl]carbamoyl]-2-azabicyclo[2.2.2]octane-2-carboxylic acid tert-butyl salt (27mg, 0.05mmol) A solution in CH ₂ Cl ₂ (1.1 mL) was added dropwise with hydrochloric acid (4N 1,4-di

alkane solution, 53 μL, 0.21 mmol). The reaction mixture was stirred at room temperature for 15 minutes. To this mixture was added MeOH (0.1 mL). The reaction mixture was stirred at room temperature for 29 hours and concentrated under vacuum to provide ( 1S , 3S , 4S )-5,5-difluoro- N -[( 1S , 2Z )-1- [[(3 S )-2-oxopyrrolidin-3-yl]methyl]-2-(2-oxotetrahydrofuran-3-yllidene)ethyl]-2-azabicyclo[2.2.2 ] Octane-3-carboxamide hydrochloride as a white foam (23 mg obtained quantitatively, observed m/z: 398 [M+H] ⁺ ), which was used in the next step without further purification.

Step (4): (1S,3S,4S)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-[(1S,2Z)-1- [[(3S)-2-oxopyrrolidin-3-yl]methyl]-2-(2-oxotetrahydrofuran-3-ylidene)ethyl]-2-azabicyclo[2.2.2] Octane-3-formamide

To (1 S ,3 S ,4 S )-5,5-difluoro- N -[(1 S ,2 Z )-1-[[(3 S )-2-oxopyrrolidin-3-yl] Methyl]-2-(2-oxotetrahydrofuran-3-ylidene)ethyl]-2-azabicyclo[2.2.2]octane-3-carboxamide hydrochloride (23mg, 0.05mmol) , 4-Methoxy- 1H -indole-2-carboxylic acid (8.5mg, 0.04mmol) and HATU (31mg, 0.08mmol) in NMP (0.89mL) were added to N-methylmorpholine (NMM ) (20 μL, 0.018 mmol). The reaction mixture was stirred at room temperature for 4 hours. Hydrochloric acid (1N in water, 5 mL) and water (5 mL) were added to the reaction mixture. The mixture was extracted with EtOAc (3 x 10 mL). The combined organics were washed with aqueous brine solution (3 x 10 mL), dried over anhydrous sodium sulfate, filtered, and concentrated in vacuo. Purification of the crude residue by reverse phase HPLC afforded ( 1S , 3S , 4S )-5,5-difluoro-2-(4-methoxy- 1H -indole-2-carbonyl) -N- [(1 S ,2 Z )-1-[[(3 S )-2-oxopyrrolidin-3-yl]methyl]-2-(2-oxotetrahydrofuran-3-ylidene)ethyl ]-2-Azabicyclo[2.2.2]octane-3-carboxamide as a white solid (13 mg, 53% yield, observed m/z: 571 [M+H] ⁺ ); ¹ H NMR (400MHz, CD ₃ OD): δ 7.15(dd,1H), 7.04(dt,1H), 6.96-6.71(m,1H), 6.49(s,1H), 6.25-5.95(m,1H), 5.77- 5.41(m,1H), 5.25-4.65(m,3H), 4.41-4.19(m,2H), 4.03-3.80(m,3H), 3.06-2.74(m,3H), 2.68(s,2H), 2.60-2.35 (m, 2H), 2.35-1.93 (m, 4H), 1.93-1.59 (m, 4H), 1.59-1.20 (m, 1H).

Example 96: (1 S ,3 S ,4 S )-2-(2-Bromo-9-hydroxy-fennel-9-carbonyl) -N -[(1 S )-1-cyano-2-[( 3S )-2-oxo-3-piperidinyl] ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide (compounds 107 and 108 )

Step (1): 2-Bromo-9-trimethylsilyloxy-fluorene-9-carbonitrile

To a solution of 2-bromofin-9-one (100 mg, 0.36 mmol) in CH ₂ Cl ₂ (0.39 mL) was added NMO (14 mg, 0.12 mmol) followed by trimethylsilyl cyanide (72 μL, 0.58 mmol). The reaction mixture was stirred under nitrogen at room temperature for 3 hours. Water (5 mL) was added to the mixture. The mixture was extracted with _CH2Cl2 (3 _x 10 mL). The combined organics were washed with aqueous brine solution (10 mL), dried over anhydrous sodium sulfate, filtered, and concentrated in vacuo to afford 2-bromo-9-trimethylsilyloxy-terrene-9-carbonitrile as White solid (115 mg, 83% yield, observed m/z: 331 [M-CN] ⁺ ), which was used in the next step without further purification.

Step (2): 2-Bromo-9-hydroxy-tertilene-9-carboxylic acid

烷(0.64mL)中的溶液加入HCl(5N的水溶液，642μL，3.2mmol)。將反應混合物在100℃下攪拌17小時。將混合物升溫至室溫並加入水(5mL)。將混合物用EtOAc(3×10mL)萃取。將合併後的有機物用水性鹽水溶液(10mL)洗滌，經無水硫酸鈉乾燥，過濾，並在真空下濃縮。將粗原料用CH₂Cl₂(5mL)稀釋並過濾。將過濾後的固體放入MeOH中並在真空下濃縮，得到2-溴-9-羥基-茀-9-羧酸，為白色固體(65mg，產率66%，觀察到m/z：287[M-OH]⁺)，其無需進一步純化即可用於下一步。 To 2-bromo-9-trimethylsilyloxy-fen-9-carbonitrile (115 mg, 0.32 mmol) in 1,4 di

To the solution in alkanes (0.64 mL) was added HCl (5N in water, 642 μL, 3.2 mmol). The reaction mixture was stirred at 100 °C for 17 hours. The mixture was warmed to room temperature and water (5 mL) was added. The mixture was extracted with EtOAc (3 x 10 mL). The combined organics were washed with aqueous brine solution (10 mL), dried over anhydrous sodium sulfate, filtered, and concentrated in vacuo. The crude material was diluted with _{CH2Cl2 (} 5 mL) and filtered. The filtered solid was taken up in MeOH and concentrated in vacuo to afford 2-bromo-9-hydroxy-tertilene-9-carboxylic acid as a white solid (65 mg, 66% yield, observed m/z: 287[ M-OH] ⁺ ), which was used in the next step without further purification.

Step (3): (1S,3S,4S)-2-(2-Bromo-9-hydroxy-fennel-9-carbonyl)-N-[(1S)-1-cyano-2-[(3S)- 2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide

2-Bromo-9-hydroxy-tertilene-9-carboxylic acid (65 mg, 0.21 mmol) and (1 S ,3 S ,4 S ) -N -[(1 S )-1-cyano- 2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide 4 - A solution of toluenesulfonic acid (110 mg, 0.21 mmol) in DMF (1 mL) was added with HATU (146 mg, 0.38 mmol) and DIPEA (149 μL, 0.85 mmol). The reaction mixture was warmed to room temperature and stirred for 4 hours. To the mixture were added HCl (IN in water, 5 mL) and water (10 mL). The mixture was extracted with EtOAc (3 x 10 mL). The combined organics were washed with an aqueous sodium bicarbonate/brine mixture (1:1, 5 mL), then brine solution (5 mL), dried over anhydrous sodium sulfate, filtered, and concentrated in vacuo. The crude residue was first purified by normal phase SiO ₂ column chromatography (0-6% MeOH/CH ₂ Cl ₂ ). The residue was then repurified by reverse phase HPLC to afford the separated diastereoisomers ( 1S , 3S , 4S )-2-(2-bromo-9-hydroxy-terpine-9-carbonyl)- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[ 2.2.2] Octane-3-carboxamide.

Major diastereomer (compound 107) : (single diastereomer I, faster eluting diastereomer): (14 mg, 11% yield, observed m/z: 627 [M+H] ⁺ ); ¹ H NMR (400MHz, CD ₃ OD): δ 7.89-7.68(m,3H), 7.68-7.59(m,2H), 7.59-7.47(m,3H), 7.47-7.37 (m,2H), 5.17(td,1H), 4.55(d,1H), 2.59(q,1H), 2.55-2.43(m,3H), 2.43-2.29(m,1H), 2.21-2.01(m ,2H), 2.01-1.74(m,4H), 1.58(d,5H), 1.33(s,2H), 1.00(s,1H)

Minor diastereomer (compound 108) : (single diastereomer II, slower eluting diastereomer): (12 mg, 9% yield, observed m/z: 627[M+H] ⁺ ); ¹ H NMR (400MHz, CD ₃ OD): δ 7.80 (ddd, 1H), 7.76-7.69 (m, 1H), 7.69-7.60 (m, 2H), 7.56-7.46 ( m,2H), 7.46-7.36(m,2H), 5.17(td,1H), 4.54(s,1H), 2.59(d,1H), 2.55-2.39(m,2H), 2.23-2.05(m, 1H), 1.95 (ddd, 2H), 1.89-1.77 (m, 1H), 1.68-1.43 (m, 4H), 1.51-1.17 (m, 3H), 1.02 (s, 1H).

Example 97: (1 S ,3 S ,4 S ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl ]-2-(2,7-difluoro-9-hydroxy-fen-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide (compound 109)

By adding (1 S ,3 S ,4 S ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]- 5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamide 4-toluenesulfonic acid was coupled with an appropriate carboxylic acid to react with respect to (1 S ,3 S ,4 S )- 2-(2-Bromo-9-hydroxy-tertene-9-carbonyl) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl ]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide to prepare (1 S ,3 S ,4 S ) -N- [(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2-(2,7-difluoro-9-hydroxy-terpineol -9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide to give a white solid (12 mg, yield 7%, observed m/z: 585 [M+H] ⁺ ). ¹ H NMR (400MHz, CD ₃ OD): δ 7.79(qd, 2H), 7.28-7.20(m, 3H), 7.15(dd, 1H), 5.17(dt, 1H), 4.56(d, 1H), 2.65 -2.43(m,3H), 2.21-2.02(m,2H), 2.02-1.87(m,3H), 1.87-1.75(m,1H), 1.74-1.51(m,5H), 1.37(s,2H) , 1.13-0.80 (m, 1H).

Example 98: (1 S ,3 S ,4 S ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl ]-2-(2,7-dichloro-9-hydroxyl-fen-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide (compound 110)

By adding (1 S ,3 S ,4 S ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]- 5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamide 4-toluenesulfonic acid was coupled with an appropriate carboxylic acid to react with respect to (1 S ,3 S ,4 S )- 2-(2-Bromo-9-hydroxy-tertene-9-carbonyl) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl ]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide to prepare (1 S ,3 S ,4 S ) -N- [(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2-(2,7-dichloro-9-hydroxy-terpineol -9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide to give a white solid (4.4 mg, 3% yield, observed m/z: 617[M+H] ⁺ ); ¹ H NMR (400MHz, CD ₃ OD): δ 7.87-7.72(m, 2H), 7.51(dddd, 3H), 7.45-7.29(m, 1H), 5.17(dt, 1H), 4.55(s,1H), 2.96(d,1H), 2.66-2.42(m,3H), 2.13(s,2H), 1.95(ddd,3H), 1.87-1.66(m,2H), 1.60 (s, 3H), 1.47-1.25 (m, 3H), 1.18-0.76 (m, 1H).

Example 99: (1 S ,3a R ,6a S ) -N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5 , 5-difluoro-2-(9-hydroxy- 9H -fen-9-carbonyl)octahydrocyclopenta[ c ]pyrrole-1-carboxamide (compound 111)

Step (1): (1S,3aR,6aS)-1-(((S)-1-amino-1-oxo-3-((S)-2-oxopiperidin-3-yl) Propan-2-yl)carbamoyl)-5,5-difluorohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate benzyl ester

(2 S )-2-amino-3-[(3 S )-2-oxo-3-piperidinyl] propionamide hydrochloride (195 mg, 0.880 mmol) and (1 S , 3a R , 6aS )-2-((benzyloxy)carbonyl)-5,5-difluorooctahydrocyclopenta[ c ]pyrrole-1-carboxylic acid (286 mg, 0.880 mmol) was dissolved in DMF (8 mL), and The reaction mixture was cooled to 0 °C. EDCI (231 mg, 1.20 mmol), HOBt monohydrate (283 mg, 1.85 mmol) and DIPEA (640 μL, 3.70 mmol) were sequentially added to the reaction mixture. The mixture was warmed to room temperature and stirred for 18 hours. The reaction mixture was diluted with _H2O (15ml) and extracted with EtOAc (3 x 20mL). The combined organic layers were dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure. The crude residue was purified by normal phase _SiO2 chromatography (10:1:0.02, _CH2Cl2 /MeOH/TEA) to afford (3S,3aS,6aR)-3- _[ [(1S)-2-amino -2-oxo-1-[[(3S)-2-oxo-3 piperidinyl]methyl]ethyl]carbamoyl]-5,5-difluoro 1,3,3a, 4,6,6a Benzyl hexahydrocyclopenta[c]pyrrole-2-carboxylate as yellow oil (200 mg, 46% yield, observed m/z: 493 [M+H] ⁺ ).

Step (2): (1S,3aR,6aS)-N-((S)-1-Amino-1-oxo-3-((S)-2-oxopiperidin-3-yl)propane -2-yl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide hydrobromide

(1S,3aR,6aS)-1-(((S)-1-amino-1-oxo-3-((S)-2-oxopiperidin-3-yl)propane-2- ( ₁₇₉ mg, 0.362 mmol) was dissolved in _CH2Cl2 (3 mL) middle. HBr (48% in H ₂ O, 84 μL, 0.51 mmol) was added dropwise, and the mixture was stirred at room temperature for 16 hours. The reaction mixture was concentrated under reduced pressure. The mixture was washed with MTBE (3×3ml) and concentrated under reduced pressure to give ( 1S , 3aR , 6aS ) -N -(( S )-1-amino-1-oxo-3-( ( S )-2-oxopiperidin-3-yl)propan-2-yl)-5,5-difluorooctahydrocyclopenta[ c ]pyrrole-1-carboxamide hydrobromide as a yellow solid (159 mg, 100% yield, observed m/z: 359 [M+H] ⁺ ), which was used in the next step without further purification.

Step (3): (1S,3aR,6aS)-N-((S)-1-Amino-1-oxo-3-((S)-2-oxopiperidin-3-yl)propane -2-yl)-5,5-difluoro-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide

(1 S ,3a R ,6a S ) -N -(( S )-1-amino-1-oxo-3-(( S )-2-oxopiperidine-3- A solution of (159 mg, 0.362 mmol ) in DMF (5 mL) was added to 9- Hydroxystilbene-9-carboxylic acid (82 mg, 0.36 mmol), DIEA (150 μL, 0.870 mmol) and HATU (172 mg, 0.452 mmol). The mixture was warmed to room temperature and stirred under nitrogen atmosphere for 2 hours. The reaction mixture was diluted with H ₂ O (15 mL), and extracted with i PrOH/CHCl ₃ (2:5 mixture, 3×15 mL). The combined organic layers were washed with brine solution (15 mL), dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to give a crude residue. Purification of the residue by reverse phase HPLC gave ( 1S , 3aR , 6aS ) -N -(( S )-1-amino-1-oxo-3-(( S )-2-oxopiper Pyridin-3-yl)propan-2-yl)-5,5-difluoro-2-(9-hydroxy- 9H -fen-9-carbonyl)octahydrocyclopenta[ c ]pyrrole-1-carboxamide , as a white solid (123 mg, 60% yield, observed m/z: 567 [M+H] ⁺ ).

Step (4): (1S,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5 -Difluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide

(1 S ,3a R ,6a S ) -N -(( S )-1-amino-1-oxo-3-(( S )-2-oxopiperidin-3-yl)propane- 2-yl)-5,5-difluoro-2-(9-hydroxy- 9H -fen-9-carbonyl)octahydrocyclopenta[ c ]pyrrole-1-carboxamide (113 mg, 0.199 μmol) and Burgess A mixture of the reagent (143 mg, 0.598 mmol) in _CH2Cl2 (2 mL) was _stirred at room temperature under a nitrogen atmosphere for 2 hours. After completion, the reaction mixture was concentrated under reduced pressure. Purification of the residue by reverse phase HPLC afforded ( 1S , 3aR , 6aS ) -N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl) Ethyl)-5,5-difluoro-2-(9-hydroxy- 9H -oxa-9-carbonyl)octahydrocyclopenta[ c ]pyrrole-1-carboxamide as a white solid (35.4 mg, yielding 32% observed m/z: 549[M+H] ⁺ ); ¹ H NMR (400MHz, DMSO-d ₆ ): δ 8.98(d,1H), 7.84(dd,2H), 7.56(s, 1H), 7.49-7.43(m,2H), 7.37-7.26(m,4H), 6.05(s,1H), 5.04(q,1H), 4.33(d,1H), 3.14-3.09(m,3H) , 2.62-2.54(m,2H), 2.47-2.46(m,1H), 2.36-2.28(m,3H), 2.19-2.12(m,1H), 2.04-1.98(m,1H), 1.95-1.90( m,1H), 1.80-1.76(m,2H), 1.67-1.63(m,1H), 1.47-1.39(m,1H), 1.07-1.03(m,1H).

Example 100: (1 S ,3a R ,6a S ) -N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5 , 5-difluoro-2-(4-fluoro-1 H -indole-2-carbonyl)octahydrocyclopenta[ c ]pyrrole-1-carboxamide (compound 112)

By adding (1 S ,3a R ,6a S ) -N -(( S )-1-amino-1-oxo-3-(( S )-2-oxopiperidin-3-yl)propane -2-yl)-5,5-difluorooctahydrocyclopenta[ c ]pyrrole-1-carboxamide hydrobromide is coupled with an appropriate carboxylic acid to combine with (1 S , 3a R , 6a S )- N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-(9-hydroxy- 9H ( 1S , 3aR , 6aS ) -N -(( S )-1-cyano -2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-(4-fluoro-1 H -indole-2-carbonyl)octahydrocyclo Penta[ c ]pyrrole-1-carboxamide; observed m/z: 502[M+H] ⁺ ; ¹ H NMR (400MHz, CD ₃ OD): δ 8.54(s, 1H), 7.32-7.04(m ,3H), 6.75(t,1H), 4.58(s,1H), 4.42-4.38(m,1H), 4.06-4.02(m,1H), 3.19-3.13(m, 3H), 2.91(s,1H) ), 2.63-2.28(m,7H), 1.98-1.61(m,5H).

Example 101: (1 S ,3a R ,6a S ) -N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-2 -(4-(Difluoromethyl)-6-fluoro- 1H -indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[ c ]pyrrole-1-carboxamide (compound 113)

By adding (1 S ,3a R ,6a S ) -N -(( S )-1-amino-1-oxo-3-(( S )-2-oxopiperidin-3-yl)propane -2-yl)-5,5-difluorooctahydrocyclopenta[ c ]pyrrole-1-carboxamide hydrobromide is coupled with an appropriate carboxylic acid to combine with (1 S , 3a R , 6a S )- N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-(9-hydroxy- 9H ( 1S , 3aR , 6aS ) -N -(( S )-1-cyano -2-(( S )-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoromethyl)-6-fluoro-1 H -indole-2-carbonyl)- 5,5-Difluorooctahydrocyclopenta[ c ]pyrrole-1-carboxamide; observed m/z: 552[M+H] ⁺ ; ¹ H NMR (400MHz, CD ₃ OD): δ 7.30(d ,1H), 7.19(s,1H), 7.11(d,1H), 5.17-5.02(m,1H), 4.61-4.54(m,1H), 4.40-4.35(m,1H), 4.05-4.00(m ,1H), 3.28-3.10(m,3H), 2.96-2.90(m,1H), 2.62-2.23(m,6H), 2.07-1.62(m,5H), 1.62-1.43(m,1H).

Example 102: (1 S ,3a R ,6a S )-2-(7-Chloro-4-(difluoromethyl)-1 H -indole-2-carbonyl) -N -(( S )-1 -cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-difluorooctahydrocyclopenta[ c ]pyrrole-1-carboxamide (compound 114)

By adding (1 S ,3a R ,6a S ) -N -(( S )-1-amino-1-oxo-3-(( S )-2-oxopiperidin-3-yl)propane -2-yl)-5,5-difluorooctahydrocyclopenta[ c ]pyrrole-1-carboxamide hydrobromide is coupled with an appropriate carboxylic acid to combine with (1 S , 3a R , 6a S )- N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-(9-hydroxy- 9H (1 S , 3a R , 6a S )-2-(7-chloro-4-(di Fluoromethyl) -1H -indole-2-carbonyl) -N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)- 5,5-Difluorooctahydrocyclopenta[ c ]pyrrole-1-carboxamide; Observed m/z: 568[M+H] ⁺ ; ¹ H NMR (400MHz, DMSO-d ₆ ): δ 12.13( s,1H), 9.05(d,1H), 7.59-7.47(m,1H), 7.42(d,1H), 7.37-7.30(m,1H), 7.20(s,1H), 6.91-6.77(m, 1H), 5.13-4.88(m,1H), 4.72-4.44(m,1H), 4.26-4.02(m,1H), 3.89(dd,1H), 3.09(s,2H), 3.00-2.70(m, 2H), 2.48-2.36(m,2H), 2.35-2.23(m,2H), 2.18-2.00(m,1H), 1.94-1.75(m,2H), 1.70(dd,1H), 1.57(d, 1H), 1.51-1.04 (m, 2H).

Example 103: (1 S ,3a R ,6a S )-2-(6-chloro-4,7-difluoro-1 H -indole-2-carbonyl) -N -(( S )-1-cyano Base-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-difluorooctahydrocyclopenta[ c ]pyrrole-1-carboxamide (compound 115)

By adding (1 S ,3a R ,6a S ) -N -(( S )-1-amino-1-oxo-3-(( S )-2-oxopiperidin-3-yl)propane -2-yl)-5,5-difluorooctahydrocyclopenta[ c ]pyrrole-1-carboxamide hydrobromide is coupled with an appropriate carboxylic acid to combine with (1 S , 3a R , 6a S )- N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-(9-hydroxy- 9H (1 S , 3a R , 6a S )-2- ( 6-chloro-4,7- Difluoro- 1H -indole-2-carbonyl) -N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5, 5-Difluorooctahydrocyclopenta[ c ]pyrrole-1-carboxamide; Observed m/z: 554[M+H] ⁺ ; ¹ H NMR (400MHz, DMSO-d ₆ ): δ 12.78-12.61( m,1H), 9.19-8.97(m,1H), 7.62-7.38(m,1H), 7.29-6.76(m,2H), 5.11-4.84(m,1H), 4.81-4.45(m,1H), 4.21(t,1H), 3.98-3.72(m,1H), 3.16-2.90(m,3H), 2.89-2.70(m,1H), 2.45-2.05(m,5H), 2.04-1.09(m,6H ).

Example 104: (1 S ,3a R ,6a S )-2-(3-chloro-4 H -thieno[3,2- b ]pyrrole-5-carbonyl) -N -(( S )-1- Cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-difluorooctahydrocyclopenta[ c ]pyrrole-1-carboxamide (Compound 116)

By adding (1 S ,3a R ,6a S ) -N -(( S )-1-amino-1-oxo-3-(( S )-2-oxopiperidin-3-yl)propane -2-yl)-5,5-difluorooctahydrocyclopenta[ c ]pyrrole-1-carboxamide hydrobromide is coupled with an appropriate carboxylic acid to combine with (1 S , 3a R , 6a S )- N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-(9-hydroxy- 9H ( 1S , 3aR , 6aS )-2-(3-chloro- 4H -thiophene And[3,2-b]pyrrole-5-carbonyl) -N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5 ,5-Difluorooctahydrocyclopenta[ c ]pyrrole-1-carboxamide; observed m/z: 524[M+H] ⁺ ; ¹ H NMR (400MHz, DMSO-d ₆ ): δ 12.20(s ,1H), 9.20-8.92(m,1H), 7.54(s,1H), 7.45(s,1H), 7.08(s,1H), 5.13-4.89(m,1H), 4.76-4.41(m,1H ), 4.25-4.03(m,1H), 3.86(d,1H), 3.09(s,3H), 2.81- 2.63(m,1H), 2.49-2.18(m,5H), 2.16-2.01(m,1H ), 1.94-1.50 (m, 4H), 1.48-1.25 (m, 1H).

Example 105: (1 S ,3a R ,6a S )-2-(7-Chloro-4,6-difluoro-1 H -indole-2-carbonyl) -N -(( S )-1- Cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-difluorooctahydrocyclopenta[ c ]pyrrole-1-carboxamide (compound 117)

By adding (1 S ,3a R ,6a S ) -N -(( S )-1-amino-1-oxo-3-(( S )-2-oxopiperidin-3-yl)propane -2-yl)-5,5-difluorooctahydrocyclopenta[ c ]pyrrole-1-carboxamide hydrobromide is coupled with an appropriate carboxylic acid to combine with (1 S , 3a R , 6a S )- N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-(9-hydroxy- 9H (1 S , 3a R , 6a S )-2- ( 7-chloro-4,6- Difluoro- 1H -indole-2-carbonyl) -N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5, 5-Difluorooctahydrocyclopenta[ c ]pyrrole-1-carboxamide; Observed m/z: 554[M+H] ⁺ ; ¹ H NMR (400MHz, DMSO): δ 11.99 (s, 1H), 8.85(d,1H), 7.27(s,1H), 7.16-6.94(m,2H), 5.06-4.91(m,1H), 4.60(s,1H), 4.21-4.00(m,1H), 3.86( dd,1H), 3.16-3.08(m,2H), 3.04-2.97(m,1H), 2.89-2.80(m,1H), 2.59-2.51(m,1H), 2.44-2.04(m,5H), 1.92-1.35(m,5H).

Example 106: ( 3S , 3aS , 6aR )-2-(7-Chloro-4-fluoro-6-methyl- 1H -indole-2-carbonyl) -N -[( 1S )- 1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-1,3,3a,4,6,6a-hexahydro Cyclopenta[ c ]pyrrole-3-carboxamide (Compound 118)

By adding (1 S ,3a R ,6a S ) -N -(( S )-1-amino-1-oxo-3-(( S )-2-oxopiperidin-3-yl)propane -2-yl)-5,5-difluorooctahydrocyclopenta[ c ]pyrrole-1-carboxamide hydrobromide is coupled with an appropriate carboxylic acid to combine with (1 S , 3a R , 6a S )- N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-(9-hydroxy- 9H (3 S , 3a S , 6a R )-2-(7-chloro-4- fluoro- 6-Methyl- 1H -indole-2-carbonyl) -N -[( 1S )-1-cyano-2-[( 3S )-2-oxo-3-piperidinyl]Ethan base]-5,5-difluoro-1,3,3a,4,6,6a-hexahydrocyclopenta[ c ]pyrrole-3-carboxamide; observed m/z: 550 [M+ H] ⁺ ; ¹ H NMR (400MHz, DMSO-d ₆ ): δ 11.35-11.27 (m, 1H), 8.86-8.82 (m, 1H), 7.27 (s, 1H), 7.00-6.84 (m, 1H) , 6.75-6.64(m,1H), 5.05-4.93(m,1H), 4.71-4.56(m,1H), 4.18-4.04(m,1H), 3.92-3.81(m,1H), 3.17-3.08( m,2H), 3.03-2.97(m,1H), 2.88-2.78(m,1H), 2.59-2.53(m,1H), 2.46-2.30(m,3H), 2.29-2.09(m,3H), 1.91-1.49 (m, 3H), 1.46-1.33 (m, 2H).

Example 107: (1 S ,3a R ,6a S ) -N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-2 -(4,7-Difluoro-6-methyl- 1H -indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[ c ]pyrrole-1-carboxamide (compound 119)

By adding (1 S ,3a R ,6a S ) -N -(( S )-1-amino-1-oxo-3-(( S )-2-oxopiperidin-3-yl)propane -2-yl)-5,5-difluorooctahydrocyclopenta[ c ]pyrrole-1-carboxamide hydrobromide is coupled with an appropriate carboxylic acid to combine with (1 S , 3a R , 6a S )- N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-(9-hydroxy- 9H ( 1S , 3aR , 6aS ) -N -(( S )-1-cyano -2-(( S )-2-oxopiperidin-3-yl)ethyl)-2-(4,7-difluoro-6-methyl-1 H -indole-2-carbonyl)-5 ,5-Difluorooctahydrocyclopenta[ c ]pyrrole-1-carboxamide; observed m/z: 534[M+H] ⁺ ; ¹ H NMR (400MHz, DMSO-d ₆ ): δ 11.92(s ,1H), 8.86-8.84(m,1H), 7.27(s,1H), 6.98-6.93(m,1H), 6.92-6.73-6.69(m,1H), 5.04-4.99(m,1H), 4.68 -4.55(m,1H), 4.22-4.01(m,1H), 3.92-3.81(m,1H), 3.18-3.09(m,3H), 3.04-2.97(m,1H), 2.64-2.61(m, 1H), 2.50-2.49(m,1H), 2.48-2.45(m,1H), 2.44-2.43(m,3H), 2.40-2.05(m,3H), 1.90-1.82(m,2H), 1.68- 1.51(m,2H), 1.42-1.33(m,1H).

Example 108: (1 S ,3a R ,6a S ) -N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-2 -(7-(Difluoromethyl)-4-fluoro- 1H -indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[ c ]pyrrole-1-carboxamide (compound 120)

By adding (1 S ,3a R ,6a S ) -N -(( S )-1-amino-1-oxo-3-(( S )-2-oxopiperidin-3-yl)propane -2-yl)-5,5-difluorooctahydrocyclopenta[ c ]pyrrole-1-carboxamide hydrobromide is coupled with an appropriate carboxylic acid to combine with (1 S , 3a R , 6a S )- N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-(9-hydroxy- 9H ( 1S , 3aR , 6aS ) -N -(( S )-1-cyano -2-(( S )-2-oxopiperidin-3-yl)ethyl)-2-(7-(difluoromethyl)-4-fluoro-1 H -indole-2-carbonyl)- 5,5-Difluorooctahydrocyclopenta[ c ]pyrrole-1-carboxamide; Observed m/z: 552[M+H] ⁺ ; ¹ H NMR (400MHz, DMSO-d ₆ ): δ 12.13( s,1H), 9.25-8.96(m,1H), 7.80-7.38(m,3H), 7.22(s,1H), 7.06-6.78(m,1H), 5.13-4.88(m,1H), 4.52( d,1H), 4.24(t,1H), 4.02-3.74(m,1H), 3.13-3.02(m,2H), 2.99-2.84(m,1H), 2.82-2.64(m,1H), 2.51( s,1H), 2.48-2.34(m,2H), 2.33-2.21(m,2H), 2.20-1.49(m,5H), 1.47-1.36(m,1H).

Example 109: (1 S ,3a R ,6a S ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5 ,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide (compound 121)

By adding (1 S ,3a R ,6a S ) -N -(( S )-1-amino-1-oxo-3-(( S )-2-oxopyrrolidin-3-yl)propane -2-yl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide hydrobromide is coupled with an appropriate carboxylic acid to combine with (1 S , 3a R , 6a S )- N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-(9-hydroxy- 9H ( 1S , 3aR , 6aS ) -N -(( S )-1-cyano -2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-(4-methoxy- 1H -indole-2-carbonyl)eta Hydrocyclopenta[ c ]pyrrole-1-carboxamide; Observed m/z: 500[M+H] ⁺ ; ¹ H NMR (400MHz, CD ₃ OD): δ 7.21-7.13 (m, 1H), 7.13 -6.80(m,2H), 6.51(d,1H), 5.05(m,1H), 4.41-4.06(m,1H), 4.05-3.82(m,4H), 3.23-3.11(m,1H), 3.08 -2.83(m,2H), 2.81-1.99(m,8H), 1.99-1.59(m,2H), 1.50-1.23(m,2H).

Example 110: N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-4,4-difluoro- 2-(9-Hydroxy-9H-fennel-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide (Compounds 122 and 123)

By adding (1 S ,3a R ,6a S ) -N -(( S )-1-amino-1-oxo-3-(( S )-2-oxopiperidin-3-yl)propane -2-yl)-4,4-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide hydrochloride is coupled with an appropriate carboxylic acid to combine with (1 S , 3a R , 6a S ) -N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-(9-hydroxy-9 H - N -(( S )-1-cyano-2-(( S ) -2 -oxo Piperidin-3-yl)ethyl)-4,4-difluoro-2-(9-hydroxy-9H-oxene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide (non-para mixture of enantiomers). N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-4,4-difluoro-2-(9 -Hydroxy-9H-Treph-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide (mixture of diastereoisomers, 41 mg).

Minor diastereomer (compound 122) : (single diastereomer I, faster eluting diastereomer): (4.6 mg, 11% yield, observed m/z : 549[M+H] ⁺ ). ¹ H NMR (400MHz, CD ₃ OD): δ 8.95(d,1H), 7.82(dd,2H), 7.48(s,2H), 7.44-7.28(m,4H), 5.05(m,1H), 4.41 (s,1H), 3.75-3.52(m,1H), 3.26(m,4H), 2.66-2.53(m,2H), 2.42-2.33(m,1H), 2.05-1.82(m,3H), 1.76 -1.66(m,2H), 1.62-1.57(d,1H), 1.28-1.20(m,2H), 0.95-0.87(s,1H).

Major diastereomer (compound 123) : (single diastereomer II, slower eluting diastereomer): (5.2 mg, 13% yield, observed m/z: 549[M+H] ⁺ ). ¹ H NMR (400MHz, CDCl ₃ ): δ 8.39(s,1H), 7.69(dd,2H), 7.44(q,2H), 7.39-7.26(m,4H), 4.93(s,1H), 4.43( s,1H), 3.35(s,1H), 2.90-2.82(m,2H), 2.79-2.72(m,2H), 2.62-2.41(m,5H), 2.13(s,1H), 1.99-1.93( m,1H), 1.88-1.83(m,1H), 1.68-1.64(m,1H), 1.31-1.19(m,2H), 0.92-0.85(s,1H).

Example 111: (1 S ,3a R ,6a S ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-4 , 4-difluoro-2-(9-hydroxy- 9H -fen-9-carbonyl)octahydrocyclopenta[ c ]pyrrole-1-carboxamide (compound 124)

By adding (1 S ,3a R ,6a S ) -N -(( S )-1-amino-1-oxo-3-(( S )-2-oxopyrrolidin-3-yl)propane -2-yl)-4,4-difluorooctahydrocyclopenta[ c ]pyrrole-1-carboxamide hydrobromide is coupled with an appropriate carboxylic acid to combine with (1 S , 3a R , 6a S )- N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-(9-hydroxy- 9H ( 1S , 3aR , 6aS ) -N -(( S )-1-cyano -2-(( S )-2-Oxopyrrolidin-3-yl)ethyl)-4,4-difluoro-2-(9-hydroxy- 9H -fennel-9-carbonyl)octahydrocyclopenta [ c ] pyrrole-1-carboxamide; observed m/z: 535[M+H] ⁺ ; ¹ H NMR (400MHz, DMSO-d ₆ ): δ 8.98(d,1H), 8.30(s,1H ), 7.90-7.68(m,3H), 7.49-7.38(m,2H), 7.37-7.22(m,4H), 6.29-6.04(m,1H), 4.98(q,1H), 4.29(d,1H ), 4.06-3.49(m,1H), 3.22-3.10(m,2H), 2.91-2.73(m,1H), 2.64-2.55(m,2H), 2.46-2.37(m,1H), 2.28-2.08 (m,2H), 2.02-1.86(m,2H), 1.86-1.53(m,3H).

Example 112: (1 S ,3a R ,6a S ) -N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-2 -(9-Hydroxy- 9H -fen-9-carbonyl)octahydrocyclopenta[ c ]pyrrole-1-carboxamide (compound 125)

By adding (1 S ,3a R ,6a S ) -N -(( S )-1-amino-1-oxo-3-(( S )-2-oxopiperidin-3-yl)propane -2-yl)octahydrocyclopenta[ c ]pyrrole-1-carboxamide hydrobromide is coupled with an appropriate carboxylic acid to combine with ( 1S , 3aR , 6aS ) -N -(( S )- 1-Cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-(9-hydroxy- 9H -oxopiperidin-9-carbonyl) ( 1S ,3aR,6aS)-N-((S ) -1 - cyano-2 - (( S ) -2-oxopiperidin-3-yl)ethyl)-2-(9-hydroxy- 9H -fluorene-9-carbonyl)octahydrocyclopenta[ c ]pyrrole-1-carboxamide; observed m /z: 513[M+H] ⁺ ; ¹ H NMR (400MHz, CD ₃ OD): δ 7.78 (dd, 2H), 7.46 (q, 2H), 7.36 (dd, 4H), 5.11 (dd, 1H) , 4.20(d,1H), 2.65-2.61(m,2H), 2.54-2.46(m,1H), 2.42-2.38(m,1H), 2.31-2.27(m,2H), 2.17-2.00(m, 2H), 1.98-1.90 (m, 2H), 1.88-1.76 (m, 2H), 1.74-1.28 (m, 7H), 0.68-0.60 (m, 1H).

Example 113: M ^pro determination

SARS-COV-2 main protease (cloned, expressed and purified from E. coli) and fluorescent substrate (peptide substrate linked to quencher:fluorophore pair at its N-terminus and C-terminus, respectively) were used To determine the inhibitory potency of the compound. Cleavage of the substrate by the main protease (M ^pro ) results in the generation of a fluorescent signal whose intensity is proportional to the amount of substrate cleaved by the enzyme. The presence of inhibitors of ^Mpro is expected to reduce the fluorescence intensity.

To determine the inhibitory activity of ^Mpro inhibitors, serial dilutions of compounds comprising an 8-point half-log dilution titration series were prepared in duplicate. These compounds were pre-incubated with the SARS-COV-2 M ^pro enzyme in black solid ½ area 96-well plates for 30 min at room temperature prior to the addition of the fluorogenic substrate. The reaction mixture consisting of enzyme, compound and substrate was incubated for an additional 90 min at 30 °C in assay buffer with a final DMSO concentration of 1%. After the incubation period, the plates were analyzed using the ^ENVISION® HTS multi-label plate reader (PerkinElmer, Shelton, CT) at Ex/Em wavelengths = 340nm/490nm.

The fluorescence signal observed as a function of compound concentration was compared to untreated (no compound) controls to determine percent inhibition. Determine the concentration of the compound that produces half-maximal inhibition ( _IC50 ) of the enzyme activity based on the dose-response curve by using the 4-parameter curve-fitting algorithm of the XL-Fit module [IDBS, Boston, MA] in Microsoft Excel software .

Enumerated implementations

The following exemplary embodiments are provided, the numbering of which should not be construed as specifying a degree of importance:

Embodiment 1 provides a compound of formula (I), or a salt, solvate, geometric isomer, stereoisomer, tautomer or any mixture thereof:

in:

、

、

、 R ¹ is selected from

,

,

,

R ^2a and R ^2b are each independently selected from H, optionally substituted C ₁ -C ₁₂ alkyl, optionally substituted C ₃ -C ₁₂ cycloalkyl, optionally substituted C ₂ -C ₁₂ hetero Cyclic and C ₇ -C ₁₂ aralkyl,

； wherein R ^2a and R ^A and one or more of R ^2a and R ^2b may be combined with the atoms to which they are bonded to form an optionally substituted C _3- C ₁₂ heterocyclyl or an optionally substituted C ₃ -C ₁₂ cycloalkyl, wherein two optional substituents thereof can combine with the atoms to which they are bonded to form optionally substituted C ₃ -C ₁₂ cycloalkyl, optionally substituted C ₂ -C ₁₂ heterocyclyl or optionally substituted phenyl; R ³ is

;

L is selected from optionally substituted C ₁ -C ₃ alkylene, -C(=O)-*, -C(=O)(optionally substituted C ₁ -C ₂ alkylene)-*, -(optionally substituted C ₁ -C ₂ alkylene)-C(=O)-* and a bond, wherein * represents the bond between L and R ^4a ;

R ^4a is selected from optionally substituted phenyl, optionally substituted C ₂ -C ₉ heteroaryl,

Wherein in R ^4a , optionally substituted phenyl or optionally substituted C ₂ -C ₉ heteroaryl is substituted by at least one halogen; R ^4b is H;

、

和

； R ^4c is selected from

,

and

;

R ^5a is selected from H, -C(=O) (optionally substituted C ₁ -C ₆ alkyl), -C(=O) (C ₁ -C ₆ haloalkyl) and optionally substituted C ₁ -C ₆ alkyl;

R ^5b is selected from H, optionally substituted C ₁ -C ₆ alkyl and optionally substituted C ₂ -C ₆ alkenyl;

^R is selected from H and halogen;

R ^6a is selected from H, optionally substituted C ₁ -C ₆ alkyl and optionally substituted phenyl;

^R6b is H,

or R ^6a and R ^6b are combined with the carbon atoms to which they are bonded to form an optionally substituted C ₃ -C ₈ cycloalkyl;

R ^6c is selected from C(=O) (optionally substituted C ₁ -C ₆ haloalkyl), C(=O) (optionally substituted C ₁ -C ₆ alkyl), optionally substituted C ₂ -C _Heteroaryl and optionally substituted phenyl;

R ^7a and R ^7b (if present) are each independently selected from H, halogen, OR ^B , optionally substituted C ₁ -C ₆ alkyl, optionally substituted C ₃ -C ₈ cycloalkyl, optionally Ground substituted C ₂ -C ₉ heterocyclyl and optionally substituted naphthyl;

Each occurrence of R ^a1 , R ^a2 , R ^a3 , R ^a4 , R ^a5 , R ^a6 , R ^a7 , R ^a8 , R ^a9 and R ^a10 (if present) is independently selected from H, halogen, CN, NO ₂ , Optionally substituted C ₁ -C ₆ alkyl, optionally substituted C ₃ -C ₈ cycloalkyl, optionally substituted C ₁ -C ₆ alkoxy, optionally substituted C ₃ -C ₈ cycloalkoxy, optionally substituted C ₂ -C ₈ heterocycloalkyl, optionally substituted phenyl, optionally substituted naphthyl, optionally substituted C- ₂ -C ₉ heteroaryl base, OR ^B , N(R ^B )(R ^C ), NO ₂ , C(=O)N(R ^B )(R ^C ), C(=O)R ^B , C(=O)OR ^B , OC (=O)R ^B , OC(=O)OR ^B , SR ^B , S(=O)R ^B , S(=O) ₂ R ^B , N(R ^B )S(=O) ₂ R ^C , N (R ^B )C(=O)R ^C and S(=O) ₂ N(R ^B )(R ^C );

Each occurrence of R ^b1 , R ^b2 and R ^b3 (if present) is independently selected from H, halogen, optionally substituted C ₁ -C ₆ alkyl, optionally substituted C ₃ -C ₈ cycloalkyl , optionally substituted C ₁ -C ₆ alkoxy, optionally substituted C ₃ -C ₈ cycloalkoxy, optionally substituted C ₂ -C ₈ heterocycloalkyl, optionally substituted Phenyl, optionally substituted naphthyl, optionally substituted C ₂ -C ₉ heteroaryl, C(=O)N(R ^B )(R ^C ), C(=O) ^RB , C( =O)OR ^B , S(=O) ^RB , S(=O) ₂ R ^B and S(=O) ₂ N(R ^B )(R ^C ),

wherein two pairs of substituents selected from R ^b1 , R ^b2 and R ^b3 can be combined with the carbon atoms to which they are bonded to form an optionally substituted C ₂ -C ₈ heterocycloalkyl or an optionally substituted C ₃ -C ₈ cycloalkyl;

Each occurrence of R ^c1 , R ^c2 , R ^c3 , R ^c4 , R ^c5 , R ^c6 , R ^c7 , R ^c8 , R ^c9 , R ^c10 and R ^c11 (if present) is independently selected from H, halogen, CN, NO ₂ , optionally substituted C ₁ -C ₆ alkyl, optionally substituted C ₃ -C ₈ cycloalkyl, optionally substituted C ₁ -C ₆ alkoxy, optionally substituted C ₃ -C ₈ cycloalkoxy, heterocyclyl, phenyl, naphthyl, heteroaryl, OR ^B , N(R ^B )(R ^C ), NO ₂ , C(=O)N(R ^B )( R ^C ), C(=O)R ^B , C(=O)OR ^B , OC(=O)R ^B , OC(=O)OR ^B , SR ^B , S(=O)R ^B , S(= O) ₂ R ^B , N( ^RB )S(=O) ₂ R ^C , N( ^RB )C(=O)R ^C and S(=O) ₂ N( ^RB )(R ^C );

Each occurrence of R ^A , R ^B and R ^C is independently selected from H, -C(=O) (optionally substituted C ₁ -C ₆ alkyl), -C(=O) (optionally substituted C ₁ -C ₆ haloalkyl), optionally substituted C ₁ -C ₆ alkyl, optionally substituted C ₁ -C ₃ haloalkyl, optionally substituted C ₃ -C ₈ cycloalkyl, Optionally substituted C ₁ -C ₆ alkoxy and optionally substituted C ₃ -C ₈ cycloalkoxy, optionally substituted phenyl, optionally substituted naphthyl and optionally substituted C ₂ -C ₉ heteroaryl;

^RD is selected from H, -C( ⁼ O) ^RB and -S(=O) _2RB ;

R ^E is selected from H, C ₁ -C ₆ alkyl and C ₁ -C ₆ haloalkyl;

each occurrence of X is independently selected from O, S and N( ^RB );

Y (if present) is selected from I, Br, Cl, F and OR ^D ;

Z ^and Z are ^each independently selected from H and halogen; and

Wherein if ^R is 4-methoxy- 1H -indolyl, at least one of the following applies:

(a) R ^2a is not isopropyl and R ^2b is not H,

(b) R ^2a is not H and R ^2b is not isopropyl, or

(c) R ^4a is not -C(=O)CH ₂ OH or -C(=O)CH ₂ OP(=O)(OH) ₂ .

Embodiment 2 provides the compound described in Embodiment 1, which is selected from:

Embodiment 3 provides the compound described in Embodiment 1 or 2, wherein one of R ^2a and R ^2b is selected from methyl, ethyl, n-propyl, isopropyl, cyclopropyl, cyclopropylmethyl, n- Butyl, second butyl, third butyl, cyclobutyl, methylcyclobutyl, n-pentyl, second pentyl, third pentyl, neopentyl, cyclopentyl, cyclopentylmethyl , n-hexyl, second hexyl, third hexyl, neohexyl, cyclohexyl and cyclohexylmethyl.

Embodiment 4 provides the compound of any one of embodiments 1-3, wherein one of R ^2a and R ^2b is H.

Embodiment 5 provides the compound described in Embodiment 1, which is selected from:

in:

R ⁸ is selected from H, optionally substituted C ₁ -C ₆ alkyl, optionally substituted C ₂ -C ₆ alkenyl, optionally substituted C ₃ -C ₈ cycloalkyl, optionally substituted C ₂ -C ₉ heterocyclyl, optionally substituted phenyl, optionally substituted naphthyl, optionally substituted C ₂ -C ₉ heteroaryl,

wherein each of the optionally substituted C ₁ -C ₆ alkyl, the optionally substituted C ₂ -C ₉ heteroaryl and the optionally substituted phenyl is optionally selected from the group consisting of C ₁ -C ₆ alkyl , C ₁ -C ₆ alkoxy and optionally substituted pyridyl by at least one substituent; and R ^d1 , R ^d2 , R ^d3 , R d4 , R ^d5 , R ^d6 , R ^{d7 ,} R ^d8 , R Each occurrence of ^d9 and ^Rd10 (if present) is independently selected from H, halogen, CN, _NO2 , optionally substituted _C1 - _C6 alkyl, optionally substituted _C3 - _C8 cycloalkane radical, optionally substituted C ₁ -C ₆ alkoxy, optionally substituted C ₃ -C ₈ cycloalkoxy, heterocyclyl, phenyl, naphthyl, heteroaryl, OR ^B , N( R ^B )(R ^C ), NO ₂ , C(=O)N(R ^B )(R ^C ), C(=O)R ^B , C(=O)OR ^B , OC(=O)R ^B , OC(=O)OR ^B , SR ^B , S(=O)R ^B , S(=O) ₂ R ^B , N(R ^B )S(=O) ₂ R ^C , N(R ^B )C(= O)R ^C and S(=O) ₂ N(R ^B )(R ^C ),

wherein two substituents selected from R ^d1 , R ^d2 , R ^d3 , R ^d4 , R ^d5 , R ^d6 , R ^d7 , R ^d8 , R ^d9 and R ^{d10 -} can combine with the atoms to which they are bonded to form Optionally substituted C ₃ -C ₈ cycloalkyl or optionally substituted C ₂ -C ₈ heterocycloalkyl.

Embodiment 6 provides the compound described in any one of Embodiments 1 and 3-5, which is selected from:

Embodiment 7 provides the compound described in Embodiment 5 or 6, wherein at least one of the following applies:

(a) each of ^Rd1 , ^Rd2 , ^Rd3 , ^Rd4 , ^Rd5 , ^Rd6 , ^Rd7 , ^Rd8 , ^Rd9 and ^Rd10 (if present) is H;

(b) nine of ^Rd1 , ^Rd2 , ^Rd3 , ^Rd4 , ^Rd5 , ^Rd6 , ^Rd7 , ^Rd8 , ^Rd9 and ^Rd10 (if present) are H;

(c) eight of ^Rd1 , ^Rd2 , ^Rd3 , ^Rd4 , ^Rd5 , ^Rd6 , ^Rd7 , ^Rd8 , ^Rd9 and ^Rd10 (if present) are H;

(d) seven of ^Rd1 , ^Rd2 , ^Rd3 , ^Rd4 , ^Rd5 , ^Rd6 , ^Rd7 , ^Rd8 , ^Rd9 and ^Rd10 (if present) are H;

(e) six of ^Rd1 , ^Rd2 , ^Rd3 , ^Rd4 , ^Rd5 , ^Rd6 , ^Rd7 , ^Rd8 , ^Rd9 and ^Rd10 (if present) are H;

(f) five of ^Rd1 , ^Rd2 , ^Rd3 , ^Rd4 , ^Rd5 , ^Rd6 , ^Rd7 , ^Rd8 , ^Rd9 and ^Rd10 (if present) are H;

(g) four of ^Rd1 , ^Rd2 , ^Rd3 , ^Rd4 , ^Rd5 , ^Rd6 , ^Rd7 , ^Rd8 , ^Rd9 and ^Rd10 (if present) are H;

(h) three of ^Rd1 , ^Rd2 , ^Rd3 , ^Rd4 , ^Rd5 , ^Rd6 , ^Rd7 , ^Rd8 , ^Rd9 and ^Rd10 (if present) are H;

(i) two of ^Rd1 , ^Rd2 , ^Rd3 , ^Rd4 , ^Rd5 , ^Rd6 , ^Rd7 , ^Rd8 , ^Rd9 and ^Rd10 (if present) are H; and

(j) one of ^Rd1 , ^Rd2 , ^Rd3 , ^Rd4 , ^Rd5 , ^Rd6 , ^Rd7 , ^Rd8 , ^Rd9 and ^Rd10 (if present) is H;

Embodiment 8 provides the compound described in any one of Embodiments 1 and 3-7, which is selected from:

Embodiment 9 provides the compound according to any one of embodiments 1-8, wherein R ^a1 , R ^a2 , R ^a3 , R ^a4 , R ^a5 , R ^a6 , R ^a7 , R ^a8 , R ^a9 and R ^a10 (if present) are each independently selected from H, Me, Br, Cl, F, OMe and _CF2H .

Embodiment 10 provides the compound of any one of Embodiments 1-9, wherein at least one of the following applies:

(a) each of R ^a1 , R ^a2 , R ^a3 , R ^a4 , R ^a5 , R ^a6 , R ^a7 , R ^a8 , R ^a9 and R ^a10 (if present) is H;

(b) nine of R ^a1 , R ^a2 , R ^a3 , R ^a4 , R ^a5 , R ^a6 , R ^a7 , R ^a8 , R ^a9 and R ^a10 (if present) are H;

(c) eight of R ^a1 , R ^a2 , R ^a3 , R ^a4 , R ^a5 , R ^a6 , R ^a7 , R ^a8 , R ^a9 and R ^a10 (if present) are H;

(d) seven of R ^a1 , R ^a2 , R ^a3 , R ^a4 , R ^a5 , R ^a6 , R ^a7 , R ^a8 , R ^a9 and R ^a10 (if present) are H;

(e) six of R ^a1 , R ^a2 , R ^a3 , R ^a4 , R ^a5 , R ^a6 , R ^a7 , R ^a8 , R ^a9 and R ^a10 (if present) are H;

(f) five of R ^a1 , R ^a2 , R ^a3 , R ^a4 , R ^a5 , R ^a6 , R ^a7 , R ^a8 , R ^a9 and R ^a10 (if present) are H;

(g) four of R ^a1 , R ^a2 , R ^a3 , R ^a4 , R ^a5 , R ^a6 , R ^a7 , R ^a8 , R ^a9 and R ^a10 (if present) are H;

(h) three of R ^a1 , R ^a2 , R ^a3 , R ^a4 , R ^a5 , R ^a6 , R ^a7 , R ^a8 , R ^a9 and R ^a10 (if present) are H;

(i) two of R ^a1 , R ^a2 , R ^a3 , R ^a4 , R ^a5 , R ^a6 , R ^a7 , R ^a8 , R ^a9 and R ^a10 (if present) are H; and

(j) one of R ^a1 , R ^a2 , R ^a3 , R ^a4 , R ^a5 , R ^a6 , R ^a7 , R ^a8 , R ^a9 and R ^a10 (if present) is H.

Embodiment 11 provides the compound described in any one of Embodiments 1-8, wherein ^R is selected from:

Embodiment 12 provides the compound of any one of embodiments 1-8 and 11, wherein R ^is selected from H, methyl, isobutyl, tert-butyl, cyclopropylmethyl, cyclobutylmethyl, and phenyl.

Embodiment 13 provides the compound of any one of Embodiments 1-8 and 11, wherein R ^6a and R ^6b combine with the carbon atom to which they are bonded to form cyclopropyl.

Embodiment 14 provides the compound according to any one of embodiments 1-8 and 11-13, wherein R ^6c is selected from C(=O)CF ₃ , C(=O)CH ₃ , is selected from C ₁ -C Pyridyl substituted by at least one substituent of ₆ alkyl and halogen, pyrazolyl substituted by at least one substituent selected from C ₁ -C ₆ alkyl and halogen, and pyrazolyl substituted by at least one substituent selected from C ₁ -C ₆ alkyl and halogen A phenyl group substituted with at least one substituent.

、

、 Embodiment 15 provides the compound according to any one of embodiments 1-8 and 11-14, wherein R ^6c is selected from C(=O)CF ₃ , C(=O)CH ₃ ,

,

,

Embodiment 16 provides the compound of any one of embodiments 1-10, wherein R ^7a and R ^7b are each independently selected from H, OH, Me, cyclopentyl, and F.

Embodiment 17 provides the compound of any one of embodiments 1-16, wherein ^R is selected from:

Embodiment 18 provides the compound of any one of Embodiments 1-17, wherein ^R is selected from:

Embodiment 19 provides the compound described in any one of Embodiments 1-18, where L is a bond.

Embodiment 20 provides the compound of any one of embodiments 1-19, wherein R ^is selected from:

Embodiment 21 provides the compound of any one of embodiments 1-20, wherein at least one of the following applies:

(a) each of ^Rc1 , ^Rc2 , ^Rc3 , ^Rc4 , ^Rc5 , ^Rc6 , ^Rc7 , ^Rc8 , ^Rc9 , ^Rc10 and ^Rc11 (if present) is H;

(b) ten of R ^c1 , R ^c2 , R ^c3 , R ^c4 , R ^c5 , R ^c6 , R ^c7 , R ^c8 , R ^c9 , R ^c10 and R ^c11 (if present) are H;

(c) nine of R ^c1 , R ^c2 , R ^c3 , R ^c4 , R ^c5 , R ^c6 , R ^c7 , R ^c8 , R ^c9 , R ^c10 and R ^c11 (if present) are H;

(d) eight of ^Rc1 , ^Rc2 , ^Rc3 , ^Rc4 , ^Rc5 , ^Rc6 , ^Rc7 , ^Rc8 , ^Rc9 , ^Rc10 and ^Rc11 (if present) are H;

(e) seven of ^Rc1 , ^Rc2 , ^Rc3 , ^Rc4 , ^Rc5 , ^Rc6 , ^Rc7 , ^Rc8 , ^Rc9 , ^Rc10 and ^Rc11 (if present) are H;

(f) six of ^Rc1 , ^Rc2 , ^Rc3 , ^Rc4 , ^Rc5 , ^Rc6 , ^Rc7 , ^Rc8 , ^Rc9 , ^Rc10 and ^Rc11 (if present) are H;

(g) five of ^Rc1 , ^Rc2 , ^Rc3 , ^Rc4 , ^Rc5 , ^Rc6 , ^Rc7 , ^Rc8 , ^Rc9 , ^Rc10 and ^Rc11 (if present) are H;

(h) four of ^Rc1 , ^Rc2 , ^Rc3 , ^Rc4 , ^Rc5 , ^Rc6 , ^Rc7 , ^Rc8 , ^Rc9 , ^Rc10 and ^Rc11 (if present) are H;

(i) three of ^Rc1 , ^Rc2 , ^Rc3 , ^Rc4 , ^Rc5 , ^Rc6 , ^Rc7 , ^Rc8 , ^Rc9 , ^Rc10 and ^Rc11 (if present) are H;

(j) two of ^Rc1 , ^Rc2 , ^Rc3 , ^Rc4 , ^Rc5 , ^Rc6 , ^Rc7 , ^Rc8 , ^Rc9 , ^Rc10 and ^Rc11 (if present) are H; and

(k) One of R ^c1 , R ^c2 , R ^c3 , R ^c4 , R ^c5 , R ^c6 , R ^c7 , R ^c8 , R ^c9 , R ^c10 and R ^c11 (if present) is H.

Embodiment 22 provides the compound of any one of embodiments 1-21, wherein at least one of the following applies:

(a) each of R ^b1 , R ^b2 and R ^b3 (if present) is H;

(b) two of R ^b1 , R ^b2 and R ^b3 (if present) are H; and

(c) One of R ^b1 , R ^b2 and R ^b3 (if present) is H.

、

、

、

、 Embodiment 23 provides the compound of any one of embodiments 1-22, wherein R ^4a is selected from CN, CHO,

,

,

,

,

、

、

、

、

和 Embodiment 24 provides the compound of any one of embodiments 1-23, wherein R ^is selected from

,

,

,

,

and

、

、

、

、

、

、 Embodiment 25 provides the compound of any one of embodiments 1-24, wherein ^R is selected from

,

,

,

,

,

,

Embodiment 26 provides the compound of any one of embodiments 1-25, wherein each occurrence of optionally substituted alkyl, optionally substituted cycloalkyl, and optionally substituted heterocycloalkyl is independently is optionally substituted by at least one of the following: C ₁ -C ₆ alkyl, C ₃ -C ₈ cycloalkyl, C ₁ -C ₆ hydroxyalkyl, halogen, CN, OR ^I , N(R ^I )(R ^II ), C ₁ -C ₆ alkoxy, C ₃ -C ₈ cycloalkoxy, C ₁ -C ₆ haloalkoxy, C ₃ -C ₈ halocycloalkoxy, optionally substituted phenyl, optionally substituted C ₂ -C ₉ heteroaryl, C(=O)R ^I , C(=O)OR ^I , OC(=O)R ^I , OC(=O)OR ^I , SR ^I , S(=O)R ^I , S(=O) ₂ R ^I , S(=O) ₂ N(R ^I )(R ^II ), S(=O) ₂ NR ^I C(=O)NHR ^II , N(R ^I )S(=O) ₂ R ^II , N(R ^I )C(=O)R ^II and C(=O)NR ^I R ^II , wherein R ^I and R ^II are each independently selected from H, -C(=O)(C ₁ -C ₆ alkyl), -C(=O)(C ₁ -C ₆ haloalkyl), C ₁ -C ₆ alkyl, C ₁ -C ₃ haloalkyl, C ₃ -C ₈ cycloalkyl, C ₁ -C ₆ alkoxy and C ₃ -C ₈ cycloalkoxy, phenyl, naphthyl and C ₂ -C ₉ heteroaryl.

Embodiment 27 provides the compound of any one of embodiments 1-26, wherein optionally substituted phenyl, optionally substituted naphthyl, optionally substituted heterocyclyl, and optionally substituted heterocyclyl Each occurrence of aryl is independently optionally substituted with at least one substituent selected from the group consisting of C ₁ -C ₆ alkyl, C ₃ -C ₈ cycloalkyl, phenyl, C ₁ -C ₆ hydroxyalkyl , C ₁ -C ₆ alkoxy, C ₃ -C ₈ cycloalkoxy, C ₁ -C ₆ haloalkyl, C ₁ -C ₆ haloalkoxy, C ₃ -C ₈ halocycloalkoxy, halogen , CN, OR ^I , N(R ^I )(R ^II ), NO ₂ , C(=O)N(R ^I )(R ^II ), C(=O)R ^I , C(=O)OR ^I , OC(=O)R ^I , OC(=O)OR ^I , SR ^I , S(=O)R ^I , S(=O) ₂ R ^I , N(R ^I )S(=O) ₂ R ^II , N(R ^I )C(=O)R ^II and S(=O) ₂ N(R ^I )(R ^II ), wherein R ^I and R ^II are each independently selected from H, -C(=O)(C ₁ -C ₆ alkyl), -C(=O)(C ₁ -C ₆ haloalkyl), C ₁ -C ₆ alkyl, C ₁ -C ₃ haloalkyl, C ₃ -C ₈ cycloalkyl, C ₁ -C ₆ alkoxy and C ₃ -C ₈ cycloalkoxy, phenyl, naphthyl and C ₂ -C ₉ heteroaryl.

Embodiment 28 provides the compound of any one of Embodiments 1-27, selected from the group consisting of:

N-(3-cyclohexyl-1-oxo-1-((1-oxo-3-(2-oxopyrrolidin-3-yl)propan-2-yl)amino)propane-2 -yl)-9-hydroxyl-9H-stilbene-9-formamide;

N-((S)-3-cyclohexyl-1-oxo-1-(((S)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl) Propan-2-yl)amino)propan-2-yl)-9-hydroxyl-9H-tila-9-carboxamide;

N-((S)-3-cyclohexyl-1-oxo-1-(((S)-1-oxo-3-((R)-2-oxopyrrolidin-3-yl) Propan-2-yl)amino)propan-2-yl)-9-hydroxyl-9H-tila-9-carboxamide;

N-((S)-3-cyclohexyl-1-oxo-1-(((R)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl) Propan-2-yl)amino)propan-2-yl)-9-hydroxyl-9H-tila-9-carboxamide;

N-((S)-3-cyclohexyl-1-oxo-1-(((R)-1-oxo-3-((R)-2-oxopyrrolidin-3-yl) Propan-2-yl)amino)propan-2-yl)-9-hydroxyl-9H-tila-9-carboxamide;

N-((R)-3-cyclohexyl-1-oxo-1-(((S)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl) Propan-2-yl)amino)propan-2-yl)-9-hydroxyl-9H-tila-9-carboxamide;

N-((R)-3-cyclohexyl-1-oxo-1-(((S)-1-oxo-3-((R)-2-oxopyrrolidin-3-yl) Propan-2-yl)amino)propan-2-yl)-9-hydroxyl-9H-tila-9-carboxamide;

N-((R)-3-cyclohexyl-1-oxo-1-(((R)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl) Propan-2-yl)amino)propan-2-yl)-9-hydroxyl-9H-tila-9-carboxamide;

N-((R)-3-cyclohexyl-1-oxo-1-(((R)-1-oxo-3-((R)-2-oxopyrrolidin-3-yl) Propan-2-yl)amino)propan-2-yl)-9-hydroxyl-9H-tila-9-carboxamide;

N-(4-(cyclopropylamino)-3,4-dioxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)-2-(2-hydroxyl-2 , 2-diphenylacetamido)-4-methylpentanamide;

(S)-N-((S)-4-(cyclopropylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2 -yl)-2-(2-hydroxy-2,2-diphenylacetamido)-4-methylpentanamide;

(S)-N-((S)-4-(cyclopropylamino)-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2 -yl)-2-(2-hydroxy-2,2-diphenylacetamido)-4-methylpentanamide;

(S)-N-((R)-4-(cyclopropylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2 -yl)-2-(2-hydroxy-2,2-diphenylacetamido)-4-methylpentanamide;

(S)-N-((R)-4-(cyclopropylamino)-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2 -yl)-2-(2-hydroxy-2,2-diphenylacetamido)-4-methylpentanamide;

(R)-N-((S)-4-(cyclopropylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2 -yl)-2-(2-hydroxy-2,2-diphenylacetamido)-4-methylpentanamide;

(R)-N-((S)-4-(cyclopropylamino)-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2 -yl)-2-(2-hydroxy-2,2-diphenylacetamido)-4-methylpentanamide;

(R)-N-((R)-4-(cyclopropylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2 -yl)-2-(2-hydroxy-2,2-diphenylacetamido)-4-methylpentanamide;

(R)-N-((R)-4-(cyclopropylamino)-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2 -yl)-2-(2-hydroxy-2,2-diphenylacetamido)-4-methylpentanamide;

N-(3-cyclohexyl-1-((4-hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)amino)-1-oxo Propan-2-yl)-9-hydroxyl-9H-oxo-9-carboxamide;

N-((S)-3-cyclohexyl-1-(((S)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-formamide;

N-((S)-3-cyclohexyl-1-(((S)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-formamide;

N-((S)-3-cyclohexyl-1-(((R)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-formamide;

N-((S)-3-cyclohexyl-1-(((R)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-formamide;

N-((R)-3-cyclohexyl-1-(((S)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-formamide;

N-((R)-3-cyclohexyl-1-(((S)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-formamide;

N-((R)-3-cyclohexyl-1-(((R)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-formamide;

N-((R)-3-cyclohexyl-1-(((R)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-formamide;

-2-甲醯胺； N-(4-Hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)-1-(9-hydroxy-9H-oxo-9-carbonyl) -4-Phenylpiperidine

-2-Formamide;

-2-甲醯胺； (S)-N-((S)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-1-( 9-Hydroxy-9H-terpinene-9-carbonyl)-4-phenylpiperene

-2-Formamide;

-2-甲醯胺； (S)-N-((S)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-1-( 9-Hydroxy-9H-terpinene-9-carbonyl)-4-phenylpiperene

-2-Formamide;

-2-甲醯胺； (S)-N-((R)-4-hydroxyl-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-1-( 9-Hydroxy-9H-terpinene-9-carbonyl)-4-phenylpiperene

-2-Formamide;

-2-甲醯胺； (S)-N-((R)-4-hydroxyl-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-1-( 9-Hydroxy-9H-terpinene-9-carbonyl)-4-phenylpiperene

-2-Formamide;

-2-甲醯胺； (R)-N-((S)-4-hydroxyl-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-1-( 9-Hydroxy-9H-terpinene-9-carbonyl)-4-phenylpiperene

-2-Formamide;

-2-甲醯胺； (R)-N-((S)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-1-( 9-Hydroxy-9H-terpinene-9-carbonyl)-4-phenylpiperene

-2-Formamide;

-2-甲醯胺； (R)-N-((R)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-1-( 9-Hydroxy-9H-terpinene-9-carbonyl)-4-phenylpiperene

-2-Formamide;

-2-甲醯胺； (R)-N-((R)-4-hydroxyl-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-1-( 9-Hydroxy-9H-terpinene-9-carbonyl)-4-phenylpiperene

-2-Formamide;

9-Hydroxy-N-(4-methyl-1-((4-(methylamino)-3,4-dioxo-1-(2-oxopyrrolidin-3-yl)butane-2- Base) amino)-1-oxopentan-2-yl)-9H-stilbene-9-carboxamide;

9-Hydroxy-N-((S)-4-methyl-1-(((S)-4-(methylamino)-3,4-dioxo-1-((S)-2-oxo Pyrrolidin-3-yl)butan-2-yl)amino)-1-oxopentan-2-yl)-9H-oxo-9-carboxamide;

9-Hydroxy-N-((S)-4-methyl-1-(((S)-4-(methylamino)-3,4-dioxo-1-((R)-2-oxo Pyrrolidin-3-yl)butan-2-yl)amino)-1-oxopentan-2-yl)-9H-oxo-9-carboxamide;

9-Hydroxy-N-((S)-4-methyl-1-(((R)-4-(methylamino)-3,4-dioxo-1-((S)-2-oxo Pyrrolidin-3-yl)butan-2-yl)amino)-1-oxopentan-2-yl)-9H-oxo-9-carboxamide;

9-Hydroxy-N-((S)-4-methyl-1-(((R)-4-(methylamino)-3,4-dioxo-1-((R)-2-oxo Pyrrolidin-3-yl)butan-2-yl)amino)-1-oxopentan-2-yl)-9H-oxo-9-carboxamide;

9-Hydroxy-N-((R)-4-methyl-1-(((S)-4-(methylamino)-3,4-dioxo-1-((S)-2-oxo Pyrrolidin-3-yl)butan-2-yl)amino)-1-oxopentan-2-yl)-9H-oxo-9-carboxamide;

9-Hydroxy-N-((R)-4-methyl-1-(((S)-4-(methylamino)-3,4-dioxo-1-((R)-2-oxo Pyrrolidin-3-yl)butan-2-yl)amino)-1-oxopentan-2-yl)-9H-oxo-9-carboxamide;

9-Hydroxy-N-((R)-4-methyl-1-(((R)-4-(methylamino)-3,4-dioxo-1-((S)-2-oxo Pyrrolidin-3-yl)butan-2-yl)amino)-1-oxopentan-2-yl)-9H-oxo-9-carboxamide;

9-Hydroxy-N-((R)-4-methyl-1-(((R)-4-(methylamino)-3,4-dioxo-1-((R)-2-oxo Pyrrolidin-3-yl)butan-2-yl)amino)-1-oxopentan-2-yl)-9H-oxo-9-carboxamide;

N-(1-((4-(ethylamino)-3,4-dioxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)amino)-4-methanol Base-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((S)-1-(((S)-4-(ethylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-formamide;

N-((S)-1-(((S)-4-(ethylamino)-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-formamide;

N-((S)-1-(((R)-4-(ethylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-formamide;

N-((S)-1-(((R)-4-(ethylamino)-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-formamide;

N-((R)-1-(((S)-4-(ethylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-formamide;

N-((R)-1-(((S)-4-(ethylamino)-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-formamide;

N-((R)-1-(((R)-4-(ethylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-formamide;

N-((R)-1-(((R)-4-(ethylamino)-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-formamide;

N-(1-((1-(4-chlorothiazol-2-yl)-1-oxo-3-(2-oxopyrrolidin-3-yl)propan-2-yl)amino)- 4-Methyl-1-oxopentan-2-yl)-4-methoxy-1H-indole-2-carboxamide;

N-((S)-1-(((S)-1-(4-chlorothiazol-2-yl)-1-oxo-3-((S)-2-oxopyrrolidine-3- Base) propan-2-yl) amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1H-indole-2-carboxamide;

N-((S)-1-(((S)-1-(4-chlorothiazol-2-yl)-1-oxo-3-((R)-2-oxopyrrolidine-3- Base) propan-2-yl) amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1H-indole-2-carboxamide;

N-((S)-1-(((R)-1-(4-chlorothiazol-2-yl)-1-oxo-3-((S)-2-oxopyrrolidine-3- Base) propan-2-yl) amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1H-indole-2-carboxamide;

N-((S)-1-(((R)-1-(4-chlorothiazol-2-yl)-1-oxo-3-((R)-2-oxopyrrolidine-3- Base) propan-2-yl) amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1H-indole-2-carboxamide;

N-((R)-1-(((S)-1-(4-chlorothiazol-2-yl)-1-oxo-3-((S)-2-oxopyrrolidine-3- Base) propan-2-yl) amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1H-indole-2-carboxamide;

N-((R)-1-(((S)-1-(4-chlorothiazol-2-yl)-1-oxo-3-((R)-2-oxopyrrolidine-3- Base) propan-2-yl) amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1H-indole-2-carboxamide;

N-((R)-1-(((R)-1-(4-chlorothiazol-2-yl)-1-oxo-3-((S)-2-oxopyrrolidine-3- Base) propan-2-yl) amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1H-indole-2-carboxamide;

N-((R)-1-(((R)-1-(4-chlorothiazol-2-yl)-1-oxo-3-((R)-2-oxopyrrolidine-3- Base) propan-2-yl) amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1H-indole-2-carboxamide;

N-(3-cyclohexyl-1-((4-(methylamino)-3,4-dioxo-1-(2-oxopyrrolidin-3-yl)butan-2-yl)amino )-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((S)-3-cyclohexyl-1-(((S)-4-(methylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidine-3 -yl)butane-2-yl)amino)-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((S)-3-cyclohexyl-1-(((S)-4-(methylamino)-3,4-dioxo-1-((R)-2-oxopyrrolidine-3 -yl)butane-2-yl)amino)-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((S)-3-cyclohexyl-1-(((R)-4-(methylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidine-3 -yl)butane-2-yl)amino)-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((S)-3-cyclohexyl-1-(((R)-4-(methylamino)-3,4-dioxo-1-((R)-2-oxopyrrolidine-3 -yl)butane-2-yl)amino)-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((R)-3-cyclohexyl-1-(((S)-4-(methylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidine-3 -yl)butane-2-yl)amino)-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((R)-3-cyclohexyl-1-(((S)-4-(methylamino)-3,4-dioxo-1-((R)-2-oxopyrrolidine-3 -yl)butane-2-yl)amino)-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((R)-3-cyclohexyl-1-(((R)-4-(methylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidine-3 -yl)butane-2-yl)amino)-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((R)-3-cyclohexyl-1-(((R)-4-(methylamino)-3,4-dioxo-1-((R)-2-oxopyrrolidine-3 -yl)butane-2-yl)amino)-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-(1-((4-amino-3,4-dioxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)amino)-3-cyclohexyl-1 -Oxopropan-2-yl)-9-hydroxy-9H-oxo-9-carboxamide;

N-((S)-1-(((S)-4-amino-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2- Base) amino)-3-cyclohexyl-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((S)-1-(((S)-4-amino-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2- Base) amino)-3-cyclohexyl-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((S)-1-(((R)-4-amino-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2- Base) amino)-3-cyclohexyl-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((S)-1-(((R)-4-amino-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2- Base) amino)-3-cyclohexyl-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((R)-1-(((S)-4-amino-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2- Base) amino)-3-cyclohexyl-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((R)-1-(((S)-4-amino-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2- Base) amino)-3-cyclohexyl-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((R)-1-(((R)-4-amino-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2- Base) amino)-3-cyclohexyl-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((R)-1-(((R)-4-amino-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2- Base) amino)-3-cyclohexyl-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-(1-((4-(cyclopropylamino)-3,4-dioxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)amino)-4 -Methyl-1-oxopentan-2-yl)-9-hydroxy-9H-stilbene-9-carboxamide;

N-((S)-1-(((S)-4-(cyclopropylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl) Butane-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((S)-1-(((S)-4-(cyclopropylamino)-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl) Butane-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((S)-1-(((R)-4-(cyclopropylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl) Butane-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((S)-1-(((R)-4-(cyclopropylamino)-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl) Butane-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((R)-1-(((S)-4-(cyclopropylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl) Butane-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((R)-1-(((S)-4-(cyclopropylamino)-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl) Butane-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((R)-1-(((R)-4-(cyclopropylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl) Butane-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((R)-1-(((R)-4-(cyclopropylamino)-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl) Butane-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

(3aR,6aS)-N-(4-Hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)-2-(4-methoxy- 1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(3aS,6aR)-N-(4-Hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)-2-(4-methoxy- 1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

N-(1-((4-amino-3,4-dioxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)amino)-4-methyl-1 -Oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((S)-1-(((S)-4-amino-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2- Base) amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((S)-1-(((S)-4-amino-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2- Base) amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((S)-1-(((R)-4-amino-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2- Base) amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((S)-1-(((R)-4-amino-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2- Base) amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((R)-1-(((S)-4-amino-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2- Base) amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((R)-1-(((S)-4-amino-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2- Base) amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((R)-1-(((R)-4-amino-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2- Base) amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-((R)-1-(((R)-4-amino-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2- Base) amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide;

N-(1-((1-(4-chlorothiazol-2-yl)-1-oxo-3-(2-oxopyrrolidin-3-yl)propan-2-yl)amino)- 3-cyclohexyl-1-oxopropan-2-yl)-4-methoxy-1H-indole-2-carboxamide;

N-((S)-1-(((S)-1-(4-chlorothiazol-2-yl)-1-oxo-3-((S)-2-oxopyrrolidine-3- Base) propan-2-yl) amino)-3-cyclohexyl-1-oxopropan-2-yl)-4-methoxy-1H-indole-2-carboxamide;

N-((S)-1-(((S)-1-(4-chlorothiazol-2-yl)-1-oxo-3-((R)-2-oxopyrrolidine-3- Base) propan-2-yl) amino)-3-cyclohexyl-1-oxopropan-2-yl)-4-methoxy-1H-indole-2-carboxamide;

N-((S)-1-(((R)-1-(4-chlorothiazol-2-yl)-1-oxo-3-((S)-2-oxopyrrolidine-3- Base) propan-2-yl) amino)-3-cyclohexyl-1-oxopropan-2-yl)-4-methoxy-1H-indole-2-carboxamide;

N-((S)-1-(((R)-1-(4-chlorothiazol-2-yl)-1-oxo-3-((R)-2-oxopyrrolidine-3- Base) propan-2-yl) amino)-3-cyclohexyl-1-oxopropan-2-yl)-4-methoxy-1H-indole-2-carboxamide;

N-((R)-1-(((S)-1-(4-chlorothiazol-2-yl)-1-oxo-3-((S)-2-oxopyrrolidine-3- Base) propan-2-yl) amino)-3-cyclohexyl-1-oxopropan-2-yl)-4-methoxy-1H-indole-2-carboxamide;

N-((R)-1-(((S)-1-(4-chlorothiazol-2-yl)-1-oxo-3-((R)-2-oxopyrrolidine-3- Base) propan-2-yl) amino)-3-cyclohexyl-1-oxopropan-2-yl)-4-methoxy-1H-indole-2-carboxamide;

N-((R)-1-(((R)-1-(4-chlorothiazol-2-yl)-1-oxo-3-((S)-2-oxopyrrolidine-3- Base) propan-2-yl) amino)-3-cyclohexyl-1-oxopropan-2-yl)-4-methoxy-1H-indole-2-carboxamide;

N-((R)-1-(((R)-1-(4-chlorothiazol-2-yl)-1-oxo-3-((R)-2-oxopyrrolidine-3- Base) propan-2-yl) amino)-3-cyclohexyl-1-oxopropan-2-yl)-4-methoxy-1H-indole-2-carboxamide;

(3aR,6aS)-N-(4-hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)-2-(9-hydroxyl-9H- Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(3aS,6aR)-N-(4-hydroxyl-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)-2-(9-hydroxyl-9H- Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

9-Hydroxy-N-(1-((4-hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)amino)-4,4- Dimethyl-1-oxopentan-2-yl)-9H-oxo-9-formamide;

9-Hydroxy-N-((S)-1-(((S)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane- 2-yl)amino)-4,4-dimethyl-1-oxopentan-2-yl)-9H-stilbene-9-carboxamide;

9-Hydroxy-N-((S)-1-(((S)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane- 2-yl)amino)-4,4-dimethyl-1-oxopentan-2-yl)-9H-stilbene-9-carboxamide;

9-Hydroxy-N-((S)-1-(((R)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane- 2-yl)amino)-4,4-dimethyl-1-oxopentan-2-yl)-9H-stilbene-9-carboxamide;

9-Hydroxy-N-((S)-1-(((R)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane- 2-yl)amino)-4,4-dimethyl-1-oxopentan-2-yl)-9H-stilbene-9-carboxamide;

9-Hydroxy-N-((R)-1-(((S)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane- 2-yl)amino)-4,4-dimethyl-1-oxopentan-2-yl)-9H-stilbene-9-carboxamide;

9-Hydroxy-N-((R)-1-(((S)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane- 2-yl)amino)-4,4-dimethyl-1-oxopentan-2-yl)-9H-stilbene-9-carboxamide;

9-Hydroxy-N-((R)-1-(((R)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane- 2-yl)amino)-4,4-dimethyl-1-oxopentan-2-yl)-9H-stilbene-9-carboxamide;

9-Hydroxy-N-((R)-1-(((R)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane- 2-yl)amino)-4,4-dimethyl-1-oxopentan-2-yl)-9H-stilbene-9-carboxamide;

N-(3-cyclohexyl-1-((4-hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)amino)-1-oxo Propan-2-yl)-9-(2,2,2-trifluoroacetamido)-9H-stilbene-9-carboxamide;

N-((S)-3-cyclohexyl-1-(((S)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-1-oxopropan-2-yl)-9-(2,2,2-trifluoroacetamido)-9H-oxo-9-formamide;

N-((S)-3-cyclohexyl-1-(((S)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-1-oxopropan-2-yl)-9-(2,2,2-trifluoroacetamido)-9H-oxo-9-formamide;

N-((S)-3-cyclohexyl-1-(((R)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-1-oxopropan-2-yl)-9-(2,2,2-trifluoroacetamido)-9H-oxo-9-formamide;

N-((S)-3-cyclohexyl-1-(((R)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-1-oxopropan-2-yl)-9-(2,2,2-trifluoroacetamido)-9H-oxo-9-formamide;

N-((R)-3-cyclohexyl-1-(((S)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-1-oxopropan-2-yl)-9-(2,2,2-trifluoroacetamido)-9H-oxo-9-formamide;

N-((R)-3-cyclohexyl-1-(((S)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-1-oxopropan-2-yl)-9-(2,2,2-trifluoroacetamido)-9H-oxo-9-formamide;

N-((R)-3-cyclohexyl-1-(((R)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-1-oxopropan-2-yl)-9-(2,2,2-trifluoroacetamido)-9H-oxo-9-formamide;

N-((R)-3-cyclohexyl-1-(((R)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-1-oxopropan-2-yl)-9-(2,2,2-trifluoroacetamido)-9H-oxo-9-formamide;

N-(4-Hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)-2-(9-hydroxy-9H-oxo-9-carbonyl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((S)-4-hydroxyl-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 9-Hydroxy-9H-Oxane-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((S)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 9-Hydroxy-9H-Oxane-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((R)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 9-Hydroxy-9H-Oxane-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((R)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 9-Hydroxy-9H-Oxane-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((S)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 9-Hydroxy-9H-Oxane-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((S)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 9-Hydroxy-9H-Oxane-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((R)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 9-Hydroxy-9H-Oxane-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((R)-4-hydroxyl-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 9-Hydroxy-9H-Oxane-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

N-(1-((4-hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)amino)-4-methyl-1-oxo Pentane-2-yl)-4-methoxy-1-propyl-1H-indole-2-carboxamide;

N-((S)-1-(((S)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) Amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1-propyl-1H-indole-2-carboxamide;

N-((S)-1-(((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) Amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1-propyl-1H-indole-2-carboxamide;

N-((S)-1-(((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) Amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1-propyl-1H-indole-2-carboxamide;

N-((S)-1-(((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) Amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1-propyl-1H-indole-2-carboxamide;

N-((R)-1-(((S)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) Amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1-propyl-1H-indole-2-carboxamide;

N-((R)-1-(((S)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) Amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1-propyl-1H-indole-2-carboxamide;

N-((R)-1-(((R)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) Amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1-propyl-1H-indole-2-carboxamide;

N-((R)-1-(((R)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) Amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1-propyl-1H-indole-2-carboxamide;

(3aR,6aS)-N-(4-Hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)-2-(1H-indole-2 -carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(3aS,6aR)-N-(4-Hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)-2-(1H-indole-2 -carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-(1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-(1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-(1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-(1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-(1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

N-(1-((4-hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)amino)-4-methyl-1-oxo Pentan-2-yl)-4-methoxy-1-(2-methylallyl)-1H-indole-2-carboxamide;

N-((S)-1-(((S)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) Amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1-(2-methylallyl)-1H-indole-2-carboxamide;

N-((S)-1-(((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl) Amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1-(2-methylallyl)-1H-indole-2-carboxamide;

N-((S)-1-(((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) Amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1-(2-methylallyl)-1H-indole-2-carboxamide;

N-((S)-1-(((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) Amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1-(2-methylallyl)-1H-indole-2-carboxamide;

N-((R)-1-(((S)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) Amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1-(2-methylallyl)-1H-indole-2-carboxamide;

N-((R)-1-(((S)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) Amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1-(2-methylallyl)-1H-indole-2-carboxamide;

N-((R)-1-(((R)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) Amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1-(2-methylallyl)-1H-indole-2-carboxamide;

N-((R)-1-(((R)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) Amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1-(2-methylallyl)-1H-indole-2-carboxamide;

N -(1-cyano-2-(2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-(9-hydroxy-9H-9-carbonyl)-2 - azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

2-(2-(3-Chlorophenyl)-2-hydroxyacetyl) -N- (1-cyano-2-(2-oxopyrrolidin-3-yl)ethyl)-5,5 - Difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )-2-(( S )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( S )-1-cyano-2- (( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )-2-(( S )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( S )-1-cyano-2- (( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )-2-(( S )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( S )-1-cyano-2- (( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )-2-(( S )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( S )-1-cyano-2- (( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )-2-(( R )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( S )-1-cyano-2- (( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )-2-(( R )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( S )-1-cyano-2- (( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )-2-(( R )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( S )-1-cyano-2- (( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )-2-(( R )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( S )-1-cyano-2- (( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )-2-(( S )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( R )-1-cyano-2- (( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )-2-(( S )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( R )-1-cyano-2- (( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )-2-(( S )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( R )-1-cyano-2- (( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )-2-(( S )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( R )-1-cyano-2- (( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )-2-(( R )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( R )-1-cyano-2- (( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )-2-(( R )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( R )-1-cyano-2- (( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )-2-(( R )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( R )-1-cyano-2- (( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )-2-(( R )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( R )-1-cyano-2- (( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )-2-(( S )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( S )-1-cyano-2- (( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 S ,3 R ,4 S )-2-(( S )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( S )-1-cyano-2- (( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 R ,3 S ,4 R )-2-(( S )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( S )-1-cyano-2- (( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 R ,3 R ,4 R )-2-(( S )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( S )-1-cyano-2- (( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 S ,3 S ,4 S )-2-(( R )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( S )-1-cyano-2- (( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 S ,3 R ,4 S )-2-(( R )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( S )-1-cyano-2- (( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 R ,3 S ,4 R )-2-(( R )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( S )-1-cyano-2- (( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 R ,3 R ,4 R )-2-(( R )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( S )-1-cyano-2- (( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 S ,3 S ,4 S )-2-(( S )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( R )-1-cyano-2- (( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 S ,3 R ,4 S )-2-(( S )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( R )-1-cyano-2- (( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 R ,3 S ,4 R )-2-(( S )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( R )-1-cyano-2- (( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 R ,3 R ,4 R )-2-(( S )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( R )-1-cyano-2- (( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 S ,3 S ,4 S )-2-(( R )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( R )-1-cyano-2- (( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 S ,3 R ,4 S )-2-(( R )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( R )-1-cyano-2- (( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 R ,3 S ,4 R )-2-(( R )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( R )-1-cyano-2- (( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 R ,3 R ,4 R )-2-(( R )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( R )-1-cyano-2- (( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

N -[1-cyano-2-[2-oxopyrrolidin-3-yl]ethyl]-2-[2-(3,5-dichlorophenyl)-2,2-difluoro-ethyl Acyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ 2-(3,5-Dichlorophenyl)-2,2-difluoro-acetyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ 2-(3,5-Dichlorophenyl)-2,2-difluoro-acetyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ 2-(3,5-Dichlorophenyl)-2,2-difluoro-acetyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ 2-(3,5-Dichlorophenyl)-2,2-difluoro-acetyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ 2-(3,5-Dichlorophenyl)-2,2-difluoro-acetyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ 2-(3,5-Dichlorophenyl)-2,2-difluoro-acetyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1 R ,3 S ,4 R )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ 2-(3,5-Dichlorophenyl)-2,2-difluoro-acetyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1 R ,3 R ,4 R )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ 2-(3,5-Dichlorophenyl)-2,2-difluoro-acetyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ 2-(3,5-Dichlorophenyl)-2,2-difluoro-acetyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ 2-(3,5-Dichlorophenyl)-2,2-difluoro-acetyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ 2-(3,5-Dichlorophenyl)-2,2-difluoro-acetyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ 2-(3,5-Dichlorophenyl)-2,2-difluoro-acetyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ 2-(3,5-Dichlorophenyl)-2,2-difluoro-acetyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ 2-(3,5-Dichlorophenyl)-2,2-difluoro-acetyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1 R ,3 S ,4 R )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ 2-(3,5-Dichlorophenyl)-2,2-difluoro-acetyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1 R ,3 R ,4 R )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ 2-(3,5-Dichlorophenyl)-2,2-difluoro-acetyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide ;

N -(1-cyano-2-(2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-(4-methoxy-1H-indole-2-carbonyl )-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

N -(1-cyano-2-(2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-(2-methyl-1H-indole-7-carbonyl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(2-methyl-1H-indole-7-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(2-methyl-1H-indole-7-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(2-methyl-1H-indole-7-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(2-methyl-1H-indole-7-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(2-methyl-1H-indole-7-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(2-methyl-1H-indole-7-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(2-methyl-1H-indole-7-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(2-methyl-1H-indole-7-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(2-methyl-1H-indole-7-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(2-methyl-1H-indole-7-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(2-methyl-1H-indole-7-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(2-methyl-1H-indole-7-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(2-methyl-1H-indole-7-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(2-methyl-1H-indole-7-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(2-methyl-1H-indole-7-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(2-methyl-1H-indole-7-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

N -(1-cyano-2-(oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-(2-hydroxy-2-phenylacryl)-2-aza Bicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( S )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( S )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( S )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( S )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( S )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( S )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( S )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( S )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( S )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( S )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( S )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( S )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( S )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( S )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( S )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( S )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( R )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( R )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( R )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( R )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( R )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( R )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( R )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( R )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( R )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( R )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( R )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( R )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( R )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( R )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( R )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( R )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

N- (1-cyano-2-(2-oxopyrrolidin-3-yl)ethyl)-2-(4-(difluoromethyl)-1H-indole-2-carbonyl)-5, 5-Difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )- N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )- N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )- N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )- N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )- N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )- N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

N-(1-cyano-2-(2-oxopyrrolidin-3-yl)ethyl)-2-(4-(difluoromethyl)-6-fluoro-1H-indole-2-carbonyl )-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )-N-(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )-N-(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )-N-(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )-N-(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )-N-(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )-N-(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )-N-(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )-N-(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )-N-(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )-N-(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )-N-(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )-N-(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )-N-(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )-N-(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )-N-(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )-N-(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

N -[1-cyano-2-[2-oxopyrrolidin-3-yl]ethyl]-2-[3-cyclobutyl-2-[(2,2,2-trifluoroacetyl )amino] propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 S ,4 R )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 R ,4 R )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 S ,4 R )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 R ,4 R )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 S ,4 R )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 R ,4 R )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 S ,4 R )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 R ,4 R )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

2-(7-Chloro-4-fluoro-1 H -indole-2-carbonyl) -N- [1-cyano-2-[2-oxo-3-piperidinyl]ethyl]-5 ,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 S ,3 S ,4 S )-2-(7-chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 S )-1-cyano-2-[( 3S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 S ,3 R ,4 S )-2-(7-Chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 S )-1-cyano-2-[( 3S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 R ,3 S ,4 R )-2-(7-chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 S )-1-cyano-2-[( 3S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 R ,3 R ,4 R )-2-(7-chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 S )-1-cyano-2-[( 3S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 S ,3 S ,4 S )-2-(7-Chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 R )-1-cyano-2-[( 3S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 S ,3 R ,4 S )-2-(7-Chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 R )-1-cyano-2-[( 3S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 R ,3 S ,4 R )-2-(7-chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 R )-1-cyano-2-[( 3S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 R ,3 R ,4 R )-2-(7-chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 R )-1-cyano-2-[( 3S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 S ,3 S ,4 S )-2-(7-chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 S )-1-cyano-2-[( 3 R )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 S ,3 R ,4 S )-2-(7-Chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 S )-1-cyano-2-[( 3 R )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 R ,3 S ,4 R )-2-(7-chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 S )-1-cyano-2-[( 3 R )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 R ,3 R ,4 R )-2-(7-chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 S )-1-cyano-2-[( 3 R )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 S ,3 S ,4 S )-2-(7-Chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 R )-1-cyano-2-[( 3 R )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 S ,3 R ,4 S )-2-(7-Chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 R )-1-cyano-2-[( 3 R )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 R ,3 S ,4 R )-2-(7-chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 R )-1-cyano-2-[( 3 R )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1 R ,3 R ,4 R )-2-(7-chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 R )-1-cyano-2-[( 3 R )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

N -(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-(9-hydroxy-9H-fennel-9-carbonyl)-2 - azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( R )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -(( R )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( R )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( R )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( S )-1-cyano-2-(( R )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -(( S )-1-cyano-2-(( R )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( S )-1-cyano-2-(( R )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( S )-1-cyano-2-(( R )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( R )-1-cyano-2-(( R )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -(( R )-1-cyano-2-(( R )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( R )-1-cyano-2-(( R )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( R )-1-cyano-2-(( R )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

N -(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-(4-methoxy-1H-indole-2-carbonyl )-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( R )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -(( R )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( R )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( R )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( S )-1-cyano-2-(( R )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -(( S )-1-cyano-2-(( R )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( S )-1-cyano-2-(( R )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( S )-1-cyano-2-(( R )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -(( R )-1-cyano-2-(( R )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -(( R )-1-cyano-2-(( R )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -(( R )-1-cyano-2-(( R )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -(( R )-1-cyano-2-(( R )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

N- [1-cyano-2-[2-oxo-3-piperidinyl]ethyl]-2-(4,7-difluoro-1 H -indole-2-carbonyl)-5, 5-Difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- (4,7-Difluoro- 1H -indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- (4,7-Difluoro- 1H -indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- (4,7-Difluoro- 1H -indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- (4,7-Difluoro- 1H -indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- (4,7-Difluoro- 1H -indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- (4,7-Difluoro- 1H -indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- (4,7-Difluoro- 1H -indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- (4,7-Difluoro- 1H -indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- (4,7-Difluoro- 1H -indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- (4,7-Difluoro- 1H -indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- (4,7-Difluoro- 1H -indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- (4,7-Difluoro- 1H -indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- (4,7-Difluoro- 1H -indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- (4,7-Difluoro- 1H -indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- (4,7-Difluoro- 1H -indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- (4,7-Difluoro- 1H -indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

N- [1-cyano-2-[2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-(4,6,7-trifluoro-1 H -ind Indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-(4,6,7-trifluoro-1 H -indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-(4,6,7-trifluoro-1 H -indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-(4,6,7-trifluoro-1 H -indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-(4,6,7-trifluoro-1 H -indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-(4,6,7-trifluoro-1 H -indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-(4,6,7-trifluoro-1 H -indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-(4,6,7-trifluoro-1 H -indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-(4,6,7-trifluoro-1 H -indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-(4,6,7-trifluoro-1 H -indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-(4,6,7-trifluoro-1 H -indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-(4,6,7-trifluoro-1 H -indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-(4,6,7-trifluoro-1 H -indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S ) -N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-(4,6,7-trifluoro-1 H -indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-(4,6,7-trifluoro-1 H -indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-(4,6,7-trifluoro-1 H -indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-(4,6,7-trifluoro-1 H -indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

2-(3-Chloro- 4H -thieno[3,2-b]pyrrole-5-carbonyl) -N- [1-cyano-2-[2-oxo-3-piperidinyl]ethyl Base]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )-2-(3-chloro-4 H -thieno[3,2-b]pyrrole-5-carbonyl) -N -[(1 S )-1-cyano- 2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )-2-(3-Chloro-4 H -thieno[3,2-b]pyrrole-5-carbonyl) -N -[(1 S )-1-cyano- 2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )-2-(3-chloro-4 H -thieno[3,2-b]pyrrole-5-carbonyl) -N -[(1 S )-1-cyano- 2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )-2-(3-chloro-4 H -thieno[3,2-b]pyrrole-5-carbonyl) -N -[(1 S )-1-cyano- 2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )-2-(3-Chloro-4 H -thieno[3,2-b]pyrrole-5-carbonyl) -N -[(1 R )-1-cyano- 2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )-2-(3-Chloro-4 H -thieno[3,2-b]pyrrole-5-carbonyl) -N -[(1 R )-1-cyano- 2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )-2-(3-chloro-4 H -thieno[3,2-b]pyrrole-5-carbonyl) -N -[(1 R )-1-cyano- 2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )-2-(3-chloro-4 H -thieno[3,2-b]pyrrole-5-carbonyl) -N -[(1 R )-1-cyano- 2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )-2-(3-chloro-4 H -thieno[3,2-b]pyrrole-5-carbonyl) -N -[(1 S )-1-cyano- 2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )-2-(3-Chloro-4 H -thieno[3,2-b]pyrrole-5-carbonyl) -N -[(1 S )-1-cyano- 2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )-2-(3-chloro-4 H -thieno[3,2-b]pyrrole-5-carbonyl) -N -[(1 S )-1-cyano- 2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )-2-(3-chloro-4 H -thieno[3,2-b]pyrrole-5-carbonyl) -N -[(1 S )-1-cyano- 2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )-2-(3-Chloro-4 H -thieno[3,2-b]pyrrole-5-carbonyl) -N -[(1 R )-1-cyano- 2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )-2-(3-Chloro-4 H -thieno[3,2-b]pyrrole-5-carbonyl) -N -[(1 R )-1-cyano- 2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )-2-(3-chloro-4 H -thieno[3,2-b]pyrrole-5-carbonyl) -N -[(1 R )-1-cyano- 2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )-2-(3-chloro-4 H -thieno[3,2-b]pyrrole-5-carbonyl) -N -[(1 R )-1-cyano- 2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N- (1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-5,5- Difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )-2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N -(( S )-1-cyano-2-((S)- 2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )-2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N -(( S )-1-cyano-2-((S)- 2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )-2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N -(( S )-1-cyano-2-((S)- 2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )-2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N -(( S )-1-cyano-2-((S)- 2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )-2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N -(( R )-1-cyano-2-((S)- 2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )-2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N -(( R )-1-cyano-2-((S)- 2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )-2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N -(( R )-1-cyano-2-((S)- 2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )-2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N -(( R )-1-cyano-2-((S)- 2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )-2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N -(( S )-1-cyano-2-((R)- 2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )-2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N -(( S )-1-cyano-2-((R)- 2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )-2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N -(( S )-1-cyano-2-((R)- 2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )-2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N -(( S )-1-cyano-2-((R)- 2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )-2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N -(( R )-1-cyano-2-((R)- 2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )-2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N -(( R )-1-cyano-2-((R)- 2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )-2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N -(( R )-1-cyano-2-((R)- 2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )-2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N -(( R )-1-cyano-2-((R)- 2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

N -[1-cyano-2-[2-oxo-3-piperidinyl]ethyl]-2-[3-cyclobutyl-2-[(2,2,2-trifluoroacetyl Base) amino] propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 R ,3 S ,4 R )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 R ,3 R ,4 R )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 R ,3 S ,4 R )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 R ,3 R ,4 R )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 R ,3 S ,4 R )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 R ,3 R ,4 R )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 R ,3 S ,4 R )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 R ,3 R ,4 R )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

N- [1-cyano-2-[2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-[4-methyl-2-[(2,2, 2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-[(2 S )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 R ,4 S ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-[(2 S )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 S ,4 R ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-[(2 S )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-[(2 S )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 S ,4 S ) -N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-[(2 S )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 R ,4 S ) -N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-[(2 S )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 S ,4 R ) -N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-[(2 S )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 R ,4 R ) -N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-[(2 S )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 S ,4 S ) -N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-[(2 S )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 R ,4 S ) -N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-[(2 S )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 S ,4 R ) -N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-[(2 S )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 R ,4 R ) -N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-[(2 S )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 S ,4 S ) -N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-[(2 S )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 R ,4 S ) -N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-[(2 S )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 S ,4 R ) -N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-[(2 S )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 R ,4 R ) -N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-[(2 S )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-Difluoro-2-[(2 R )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 R ,4 S ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-Difluoro-2-[(2 R )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 S ,4 R ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-Difluoro-2-[(2 R )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-Difluoro-2-[(2 R )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 S ,4 S ) -N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-Difluoro-2-[(2 R )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 R ,4 S ) -N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-Difluoro-2-[(2 R )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 S ,4 R ) -N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-Difluoro-2-[(2 R )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 R ,4 R ) -N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-Difluoro-2-[(2 R )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 S ,4 S ) -N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-Difluoro-2-[(2 R )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 R ,4 S ) -N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-Difluoro-2-[(2 R )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 S ,4 R ) -N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-Difluoro-2-[(2 R )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 R ,4 R ) -N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-Difluoro-2-[(2 R )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 S ,4 S ) -N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-Difluoro-2-[(2 R )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 R ,4 S ) -N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-Difluoro-2-[(2 R )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 S ,4 R ) -N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-Difluoro-2-[(2 R )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 R ,4 R ) -N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-Difluoro-2-[(2 R )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide;

N -[1-cyano-2-[2-oxo-3-piperidinyl]ethyl]-2-[3-cyclopropyl-2-[(2,2,2-trifluoroacetyl Base) amino] propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide;

N -[1-cyano-2-[2-oxo-3-piperidinyl]ethyl]-2-[3,3-dimethyl-2-[(2,2,2-trifluoro Acetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2S)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2S)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2S)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2S)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2S)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2S)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 S ,4 R )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2S)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 R ,4 R )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2S)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2S)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2S)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2S)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2S)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2S)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2S)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 S ,4 R )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2S)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 R ,4 R )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2S)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2R)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2R)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2R)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2R)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2R)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2R)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 S ,4 R )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2R)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 R ,4 R )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2R)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2R)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2R)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2R)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2R)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2R)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2R)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 S ,4 R )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2R)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

(1 R ,3 R ,4 R )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2R)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide;

N -[1-cyano-2-[2-oxo-3-piperidinyl]ethyl]-2-[2-(2,5-difluoroaniline)propionyl]-5,5- Difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3S)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 S )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3S)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 S )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3S)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 S )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3S)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 S )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3S)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 S )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3S)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 S )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )- N -[(1 R )-1-cyano-2-[(3S)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 S )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )- N -[(1 R )-1-cyano-2-[(3S)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 S )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3R)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 S )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3R)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 S )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3R)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 S )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3R)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 S )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3R)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 S )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -[(1 R )-1-cyano-2-[(3R)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 S )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -[(1 R )-1-cyano-2-[(3R)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 S )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -[(1 R )-1-cyano-2-[(3R)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 S )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3S)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 R )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3S)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 R )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3S)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 R )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3S)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 R )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3S)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 R )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3S)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 R )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )- N -[(1 R )-1-cyano-2-[(3S)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 R )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )- N -[(1 R )-1-cyano-2-[(3S)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 R )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3R)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 R )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3R)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 R )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3R)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 R )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3R)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 R )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3R)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 R )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 R ,4 S ) -N -[(1 R )-1-cyano-2-[(3R)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 R )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 S ,4 R ) -N -[(1 R )-1-cyano-2-[(3R)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 R )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 R ,3 R ,4 R ) -N -[(1 R )-1-cyano-2-[(3R)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 R )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

2-[2-(3-Chloro-2-methyl-aniline)propionyl]-N-[1-cyano-2-[2-oxo-3-piperidinyl]ethyl]-5 ,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1S,3S,4S)-2-[(2S)-2-(3-Chloro-2-methyl-aniline)propionyl]-N-[(1S)-1-cyano-2-[( 3S)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-[(2S)-2-(3-Chloro-2-methyl-aniline)propionyl]-N-[(1S)-1-cyano-2-[( 3S)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-[(2S)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1S)-1-cyano-2-[( 3S)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-[(2S)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1S)-1-cyano-2-[( 3S)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-[(2R)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1S)-1-cyano-2-[( 3S)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-[(2R)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1S)-1-cyano-2-[( 3S)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-[(2R)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1S)-1-cyano-2-[( 3S)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-[(2R)-2-(3-Chloro-2-methyl-aniline)propionyl]-N-[(1S)-1-cyano-2-[( 3S)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-[(2S)-2-(3-Chloro-2-methyl-aniline)propionyl]-N-[(1R)-1-cyano-2-[( 3S)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-[(2S)-2-(3-Chloro-2-methyl-aniline)propionyl]-N-[(1R)-1-cyano-2-[( 3S)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-[(2S)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1R)-1-cyano-2-[( 3S)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-[(2S)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1R)-1-cyano-2-[( 3S)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-[(2R)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1R)-1-cyano-2-[( 3S)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-[(2R)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1R)-1-cyano-2-[( 3S)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-[(2R)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1R)-1-cyano-2-[( 3S)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-[(2R)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1R)-1-cyano-2-[( 3S)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-[(2S)-2-(3-Chloro-2-methyl-aniline)propionyl]-N-[(1S)-1-cyano-2-[( 3R)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1S,3R,4S)-2-[(2S)-2-(3-Chloro-2-methyl-aniline)propionyl]-N-[(1S)-1-cyano-2-[( 3R)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1R,3S,4R)-2-[(2S)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1S)-1-cyano-2-[( 3R)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1R,3R,4R)-2-[(2S)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1S)-1-cyano-2-[( 3R)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1S,3S,4S)-2-[(2R)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1S)-1-cyano-2-[( 3R)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1S,3R,4S)-2-[(2R)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1S)-1-cyano-2-[( 3R)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1R,3S,4R)-2-[(2R)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1S)-1-cyano-2-[( 3R)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1R,3R,4R)-2-[(2R)-2-(3-Chloro-2-methyl-aniline)propionyl]-N-[(1S)-1-cyano-2-[( 3R)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1S,3S,4S)-2-[(2S)-2-(3-Chloro-2-methyl-aniline)propionyl]-N-[(1R)-1-cyano-2-[( 3R)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1S,3R,4S)-2-[(2S)-2-(3-Chloro-2-methyl-aniline)propionyl]-N-[(1R)-1-cyano-2-[( 3R)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1R,3S,4R)-2-[(2S)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1R)-1-cyano-2-[( 3R)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1R,3R,4R)-2-[(2S)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1R)-1-cyano-2-[( 3R)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1S,3S,4S)-2-[(2R)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1R)-1-cyano-2-[( 3R)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1S,3R,4S)-2-[(2R)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1R)-1-cyano-2-[( 3R)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1R,3S,4R)-2-[(2R)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1R)-1-cyano-2-[( 3R)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1R,3R,4R)-2-[(2R)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1R)-1-cyano-2-[( 3R)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

N-(4-hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)-2-(2-methyl-4H-thieno[3, 2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-formamide;

(S)-N-((S)-4-hydroxyl-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 2-methyl-4H-thieno[3,2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((S)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 2-methyl-4H-thieno[3,2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((R)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 2-methyl-4H-thieno[3,2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((R)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 2-methyl-4H-thieno[3,2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((S)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 2-methyl-4H-thieno[3,2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((S)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 2-methyl-4H-thieno[3,2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((R)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 2-methyl-4H-thieno[3,2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((R)-4-hydroxyl-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 2-methyl-4H-thieno[3,2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

2-(3-Chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-(4-hydroxy-3-oxo-1-(2-oxopyrrolidine-3- Base) butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-4-hydroxyl-3-oxo-1-(( S) -2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-4-hydroxyl-3-oxo-1-(( R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-2-(3-Chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-4-hydroxyl-3-oxo-1-(( S) -2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-2-(3-Chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-4-hydroxyl-3-oxo-1-(( R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-4-hydroxyl-3-oxo-1-(( S) -2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-4-hydroxyl-3-oxo-1-(( R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-4-hydroxyl-3-oxo-1-(( S) -2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-4-hydroxyl-3-oxo-1-(( R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

N-(4-Hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)-2-(4-methoxy-1H-indole-2 -carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((S)-4-hydroxyl-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((S)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((R)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((R)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((S)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((S)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((R)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((R)-4-hydroxyl-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

N-(4-hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)-2-(3-methyl-4H-thieno[3, 2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-formamide;

(S)-N-((S)-4-hydroxyl-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 3-methyl-4H-thieno[3,2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((S)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 3-methyl-4H-thieno[3,2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((R)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 3-methyl-4H-thieno[3,2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((R)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 3-methyl-4H-thieno[3,2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((S)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 3-methyl-4H-thieno[3,2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((S)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 3-methyl-4H-thieno[3,2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((R)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 3-methyl-4H-thieno[3,2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((R)-4-hydroxyl-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 3-methyl-4H-thieno[3,2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

2-(4,6-Difluoro-1H-indole-2-carbonyl)-N-(4-hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane- 2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-2-(4,6-difluoro-1H-indole-2-carbonyl)-N-((S)-4-hydroxy-3-oxo-1-((S)-2- Oxypyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-2-(4,6-difluoro-1H-indole-2-carbonyl)-N-((S)-4-hydroxy-3-oxo-1-((R)-2- Oxypyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-2-(4,6-difluoro-1H-indole-2-carbonyl)-N-((R)-4-hydroxy-3-oxo-1-((S)-2- Oxypyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-2-(4,6-difluoro-1H-indole-2-carbonyl)-N-((R)-4-hydroxy-3-oxo-1-((R)-2- Oxypyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-2-(4,6-difluoro-1H-indole-2-carbonyl)-N-((S)-4-hydroxy-3-oxo-1-((S)-2- Oxypyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-2-(4,6-difluoro-1H-indole-2-carbonyl)-N-((S)-4-hydroxy-3-oxo-1-((R)-2- Oxypyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-2-(4,6-difluoro-1H-indole-2-carbonyl)-N-((R)-4-hydroxy-3-oxo-1-((S)-2- Oxypyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-2-(4,6-difluoro-1H-indole-2-carbonyl)-N-((R)-4-hydroxy-3-oxo-1-((R)-2- Oxypyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

2-(9-fluoro-9H-9-carbonyl)-N-(4-hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-(9-fluoro-9H-fennel-9-carbonyl)-N-((S)-4-hydroxyl-3-oxo-1-((S)-2- Oxypyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-(9-Fluoro-9H-fennel-9-carbonyl)-N-((S)-4-hydroxy-3-oxo-1-((R)-2- Oxypyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-(9-fluoro-9H-9-carbonyl)-N-((R)-4-hydroxy-3-oxo-1-((S)-2- Oxypyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-(9-Fluoro-9H-fennel-9-carbonyl)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2- Oxypyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-(9-Fluoro-9H-fennel-9-carbonyl)-N-((S)-4-hydroxy-3-oxo-1-((S)-2- Oxypyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-(9-Fluoro-9H-fennel-9-carbonyl)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2- Oxypyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-(9-Fluoro-9H-fennel-9-carbonyl)-N-((R)-4-hydroxyl-3-oxo-1-((S)-2- Oxypyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-(9-Fluoro-9H-fennel-9-carbonyl)-N-((R)-4-hydroxyl-3-oxo-1-((R)-2- Oxypyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-(9-fluoro-9H-fennel-9-carbonyl)-N-((S)-4-hydroxyl-3-oxo-1-((S)-2- Oxypyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-(9-Fluoro-9H-fennel-9-carbonyl)-N-((S)-4-hydroxy-3-oxo-1-((R)-2- Oxypyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-(9-Fluoro-9H-fennel-9-carbonyl)-N-((R)-4-hydroxyl-3-oxo-1-((S)-2- Oxypyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-(9-Fluoro-9H-fennel-9-carbonyl)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2- Oxypyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-(9-Fluoro-9H-fennel-9-carbonyl)-N-((S)-4-hydroxy-3-oxo-1-((S)-2- Oxypyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-(9-Fluoro-9H-fennel-9-carbonyl)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2- Oxypyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-(9-Fluoro-9H-fennel-9-carbonyl)-N-((R)-4-hydroxyl-3-oxo-1-((S)-2- Oxypyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-(9-Fluoro-9H-fennel-9-carbonyl)-N-((R)-4-hydroxyl-3-oxo-1-((R)-2- Oxypyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

2-(9-Acetamido-9H-oxo-9-carbonyl)-N-(4-hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2 -yl) octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-(9-Acetamido-9H-oxo-9-carbonyl)-N-((S)-4-hydroxy-3-oxo-1-((S) -2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-(9-Acetamido-9H-oxo-9-carbonyl)-N-((S)-4-hydroxy-3-oxo-1-((R) -2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-(9-Acetamido-9H-oxo-9-carbonyl)-N-((R)-4-hydroxy-3-oxo-1-((S) -2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-(9-Acetamido-9H-oxo-9-carbonyl)-N-((R)-4-hydroxy-3-oxo-1-((R) -2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-(9-Acetamido-9H-oxo-9-carbonyl)-N-((S)-4-hydroxyl-3-oxo-1-((S) -2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-(9-Acetamido-9H-oxo-9-carbonyl)-N-((S)-4-hydroxy-3-oxo-1-((R) -2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-(9-Acetamido-9H-oxo-9-carbonyl)-N-((R)-4-hydroxy-3-oxo-1-((S) -2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-(9-Acetamido-9H-oxo-9-carbonyl)-N-((R)-4-hydroxy-3-oxo-1-((R) -2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-(9-Acetamido-9H-oxo-9-carbonyl)-N-((S)-4-hydroxy-3-oxo-1-((S) -2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-(9-Acetamido-9H-oxo-9-carbonyl)-N-((S)-4-hydroxy-3-oxo-1-((R) -2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-(9-Acetamido-9H-oxo-9-carbonyl)-N-((R)-4-hydroxy-3-oxo-1-((S) -2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-(9-Acetamido-9H-oxo-9-carbonyl)-N-((R)-4-hydroxy-3-oxo-1-((R) -2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-(9-Acetamido-9H-oxo-9-carbonyl)-N-((S)-4-hydroxyl-3-oxo-1-((S) -2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-(9-Acetamido-9H-oxo-9-carbonyl)-N-((S)-4-hydroxy-3-oxo-1-((R) -2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-(9-Acetamido-9H-oxo-9-carbonyl)-N-((R)-4-hydroxy-3-oxo-1-((S) -2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-(9-Acetamido-9H-oxo-9-carbonyl)-N-((R)-4-hydroxy-3-oxo-1-((R) -2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

N-(4-Hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)-2-(5-oxo-2-phenylpyrrolidine -2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-(5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((S)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-((R)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((S)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((R)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-((S)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-((R)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((S)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((R)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((S)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((R)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-((S)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-((R)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((S)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((R)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((S)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-((R)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((S)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((R)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-((S)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((R)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-((S)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-((R)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-((S)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-((R)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((S)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((R)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-((S)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-((R)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((S)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((R)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((S)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((R)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

2-(2-Cyclopentyl-2-hydroxy-2-phenylacetyl)-N-(4-hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane -2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(3S)-2-(2-Cyclopentyl-2-hydroxy-2-phenylacetyl)-N-((S)-4-hydroxy-3-oxo-1-((S)-2 -Oxopyrrolidin-3-yl)butan-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-2-((S)-2-cyclopentyl-2-hydroxyl-2-phenylacetyl)-N-((S)-4-hydroxyl-3-oxo-1-(( S) -2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-2-((S)-2-cyclopentyl-2-hydroxyl-2-phenylacetyl)-N-((S)-4-hydroxyl-3-oxo-1-(( R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-2-((S)-2-cyclopentyl-2-hydroxyl-2-phenylacetyl)-N-((R)-4-hydroxyl-3-oxo-1-(( S) -2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-2-((S)-2-cyclopentyl-2-hydroxyl-2-phenylacetyl)-N-((R)-4-hydroxyl-3-oxo-1-(( R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-2-((R)-2-cyclopentyl-2-hydroxyl-2-phenylacetyl)-N-((S)-4-hydroxyl-3-oxo-1-(( S) -2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-2-((R)-2-cyclopentyl-2-hydroxyl-2-phenylacetyl)-N-((S)-4-hydroxyl-3-oxo-1-(( R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-2-((R)-2-cyclopentyl-2-hydroxyl-2-phenylacetyl)-N-((R)-4-hydroxyl-3-oxo-1-(( S) -2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-2-((R)-2-cyclopentyl-2-hydroxyl-2-phenylacetyl)-N-((R)-4-hydroxyl-3-oxo-1-(( R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-2-((S)-2-cyclopentyl-2-hydroxyl-2-phenylacetyl)-N-((S)-4-hydroxyl-3-oxo-1-(( S) -2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-2-((S)-2-cyclopentyl-2-hydroxyl-2-phenylacetyl)-N-((S)-4-hydroxyl-3-oxo-1-(( R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-2-((S)-2-cyclopentyl-2-hydroxyl-2-phenylacetyl)-N-((R)-4-hydroxyl-3-oxo-1-(( S) -2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-2-((S)-2-cyclopentyl-2-hydroxyl-2-phenylacetyl)-N-((R)-4-hydroxyl-3-oxo-1-(( R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-2-((R)-2-cyclopentyl-2-hydroxy-2-phenylacetyl)-N-((S)-4-hydroxy-3-oxo-1-(( S) -2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-2-((R)-2-cyclopentyl-2-hydroxy-2-phenylacetyl)-N-((S)-4-hydroxy-3-oxo-1-(( R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-2-((R)-2-cyclopentyl-2-hydroxyl-2-phenylacetyl)-N-((R)-4-hydroxyl-3-oxo-1-(( S) -2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-2-((R)-2-cyclopentyl-2-hydroxyl-2-phenylacetyl)-N-((R)-4-hydroxyl-3-oxo-1-(( R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

N-(1-cyano-2-(2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo [2.2.2] Octane-3-formamide;

(S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy-1H-ind Indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy-1H-ind Indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2,-(4-methoxy-1H- Indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy-1H-ind Indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy-1H-ind Indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy-1H-ind Indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy-1H-ind Indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy-1H-ind Indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

2-(3-Chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-(1-cyano-2-(2-oxopyrrolidin-3-yl)ethyl) -5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-(3-Chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-1-cyano-2-((S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-(3-Chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-1-cyano-2-((R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-1-cyano-2-((S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-(3-Chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-1-cyano-2-((R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-1-cyano-2-((S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-(3-Chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-1-cyano-2-((R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-1-cyano-2-((S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-1-cyano-2-((R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-(3-Chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-1-cyano-2-((S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-(3-Chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-1-cyano-2-((R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-1-cyano-2-((S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-1-cyano-2-((R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-1-cyano-2-((S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-1-cyano-2-((R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-1-cyano-2-((S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-1-cyano-2-((R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,2S,5S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-3-(9-hydroxyl-9H -Treme-9-carbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide;

N-(1-cyano-2-(2-oxopyrrolidin-3-yl)ethyl)-3-(9-hydroxy-9H-fenflure-9-carbonyl)-6,6-dimethyl- 3-Azabicyclo[3.1.0]hexane-2-carboxamide;

(1R,2S,5S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-3-(9-hydroxyl-9H -Treme-9-carbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide;

(1R,2S,5S)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-3-(9-hydroxyl-9H -Treme-9-carbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide;

(1R,2S,5S)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-3-(9-hydroxyl-9H -Treme-9-carbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide;

(1R,2S,5S)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-3-(9-hydroxyl-9H -Treme-9-carbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide;

(1S,2S,5R)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-3-(9-hydroxyl-9H -Treme-9-carbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide;

(1S,2S,5R)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-3-(9-hydroxyl-9H -Treme-9-carbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide;

(1S,2S,5R)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-3-(9-hydroxyl-9H -Treme-9-carbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide;

(1S,2S,5R)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-3-(9-hydroxyl-9H -Treme-9-carbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide;

(1R,2R,5S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-3-(9-hydroxyl-9H -Treme-9-carbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide;

(1R,2R,5S)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-3-(9-hydroxyl-9H -Treme-9-carbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide;

(1R,2R,5S)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-3-(9-hydroxyl-9H -Treme-9-carbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide;

(1R,2R,5S)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-3-(9-hydroxyl-9H -Treme-9-carbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide;

(1S,2R,5R)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-3-(9-hydroxyl-9H -Treme-9-carbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide;

(1S,2R,5R)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-3-(9-hydroxyl-9H -Treme-9-carbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide;

(1S,2R,5R)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-3-(9-hydroxyl-9H -Treme-9-carbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide;

(1S,2R,5R)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-3-(9-hydroxyl-9H -Treme-9-carbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide;

N-(1-cyano-2-(2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-((2,2,2-trifluoroacetyl)- Leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-D-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-L-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-D-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-L-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-D-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-L-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-D-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-L-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-D-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-L-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-D-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-L-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-D-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-L-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-D-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-L-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-D-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-L-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-D-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-L-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-D-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-L-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-D-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-L-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-D-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-L-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-D-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-L-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-D-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-L-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-D-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-L-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

N-(1-cyano-2-(2-oxopyrrolidin-3-yl)ethyl)-2-(3-cyclobutyl-2-(2,2,2-trifluoroacetamido ) propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3S,4S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3S,4S)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3S,4S)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3S,4S)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3S,4S)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3S,4S)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3S,4S)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3S,4R)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3S,4R)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3S,4R)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3S,4R)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3S,4R)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3S,4R)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3S,4R)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3S,4R)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3R,4S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3R,4S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3R,4S)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3R,4S)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3R,4S)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3R,4S)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3R,4S)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3R,4S)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3R,4R)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3R,4R)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3R,4R)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3R,4R)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3R,4R)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3R,4R)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3R,4R)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3R,4R)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine;

2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N- (1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-5,5- Difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1 S ,3 S ,4 S )-2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N -(( S )-1-cyano-2-((S)- 2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((S)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((S)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((S)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((S)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((R)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((R)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((R)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((R)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((S)-2-chloro-9-hydroxyl-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((S)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((S)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((S)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((R)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((R)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((R)-2-Chloro-9-hydroxy-9H-9-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((R)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((S)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((S)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((S)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((S)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((R)-2-Chloro-9-hydroxyl-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((R)-2-Chloro-9-hydroxy-9H-9-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((R)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((R)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((S)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((S)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((S)-2-chloro-9-hydroxyl-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((S)-2-chloro-9-hydroxyl-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((R)-2-chloro-9-hydroxyl-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((R)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((R)-2-chloro-9-hydroxyl-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((R)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo [2.2.2] Octane-3-formamide;

(S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-methoxy-1H-ind Indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-methoxy-1H-ind Indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-methoxy-1H-ind Indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-methoxy-1H-ind Indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-methoxy-1H-ind Indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-methoxy-1H-ind Indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-methoxy-1H-ind Indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-methoxy-1H-ind Indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-D-leucyl)-N-((S)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-D-leucyl)-N-((S)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-D-leucyl)-N-((S)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-D-leucyl)-N-((R)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-D-leucyl)-N-((R)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-L-leucyl)-N-((S)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-L-leucyl)-N-((S)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-L-leucyl)-N-((R)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-L-leucyl)-N-((R)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-D-leucyl)-N-((S)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-D-leucyl)-N-((S)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-D-leucyl)-N-((R)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-D-leucyl)-N-((R)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-L-leucyl)-N-((S)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-L-leucyl)-N-((S)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-L-leucyl)-N-((R)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-L-leucyl)-N-((R)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((3-Chlorophenyl)-D-leucyl)-N-((S)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((3-Chlorophenyl)-D-leucyl)-N-((S)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((3-Chlorophenyl)-D-leucyl)-N-((R)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((3-Chlorophenyl)-D-leucyl)-N-((R)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((3-Chlorophenyl)-L-leucyl)-N-((S)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((3-Chlorophenyl)-L-leucyl)-N-((S)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((3-Chlorophenyl)-L-leucyl)-N-((R)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((3-Chlorophenyl)-L-leucyl)-N-((R)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((3-Chlorophenyl)-D-leucyl)-N-((S)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((3-Chlorophenyl)-D-leucyl)-N-((S)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((3-Chlorophenyl)-D-leucyl)-N-((R)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((3-Chlorophenyl)-D-leucyl)-N-((R)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((3-Chlorophenyl)-L-leucyl)-N-((S)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((3-Chlorophenyl)-L-leucyl)-N-((S)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((3-Chlorophenyl)-L-leucyl)-N-((R)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((3-Chlorophenyl)-L-leucyl)-N-((R)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

2-(2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl Base)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((S)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((S)-1-cyano -2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((S)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((S)-1-cyano -2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((S)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((R)-1-cyano -2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((S)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((R)-1-cyano -2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((R)-2-((3-Chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((S)-1-cyano -2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((R)-2-((3-Chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((S)-1-cyano -2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((R)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((R)-1-cyano -2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((R)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((R)-1-cyano -2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((S)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((S)-1-cyano -2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((S)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((S)-1-cyano -2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((S)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((R)-1-cyano -2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((S)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((R)-1-cyano -2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((R)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((S)-1-cyano -2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((R)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((S)-1-cyano -2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((R)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((R)-1-cyano -2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((R)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((R)-1-cyano -2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((S)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((S)-1-cyano -2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((S)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((S)-1-cyano -2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((S)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((R)-1-cyano -2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((S)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((R)-1-cyano -2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((R)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((S)-1-cyano -2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((R)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((S)-1-cyano -2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((R)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((R)-1-cyano -2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((R)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((R)-1-cyano -2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((S)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((S)-1-cyano -2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((S)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((S)-1-cyano -2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((S)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((R)-1-cyano -2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((S)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((R)-1-cyano -2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((R)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((S)-1-cyano -2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((R)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((S)-1-cyano -2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((R)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((R)-1-cyano -2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((R)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((R)-1-cyano -2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-2-(3-cyclopropyl-2-((5-methylpyridin-3-yl)amine Base) propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3S,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3S,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3S,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3S,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3S,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3S,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3S,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3S,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3S,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3S,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3S,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3S,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3S,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3S,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3S,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3R,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3R,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3R,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3R,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3R,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3R,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3R,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3R,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3R,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3R,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3R,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3R,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3R,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3R,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3R,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3R,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl)-propanamidoyl)-5,5-di Fluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-D-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-L-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-D-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-L-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-D-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-L-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-D-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-L-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-D-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-L-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-D-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-L-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-D-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-L-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-D-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-L-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-D-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-L-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-D-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-L-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-D-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-L-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-D-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-L-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-D-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-L-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-D-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-L-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-D-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-L-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-D-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-L-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

2-((5-Chloropyridin-3-yl)-propanylamino)-N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((5-Chloropyridin-3-yl)-D-propanylamino)-N-((S)-1-cyano-2-((S)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((5-Chloropyridin-3-yl)-D-propanylamino)-N-((S)-1-cyano-2-((R)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((5-Chloropyridin-3-yl)-D-propanylamino)-N-((R)-1-cyano-2-((S)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((5-Chloropyridin-3-yl)-D-propanylamino)-N-((R)-1-cyano-2-((R)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((5-Chloropyridin-3-yl)-L-propanylamino)-N-((S)-1-cyano-2-((S)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((5-Chloropyridin-3-yl)-L-propanylamino)-N-((S)-1-cyano-2-((R)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((5-Chloropyridin-3-yl)-L-propanylamino)-N-((R)-1-cyano-2-((S)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((5-Chloropyridin-3-yl)-L-propanylamino)-N-((R)-1-cyano-2-((R)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((5-Chloropyridin-3-yl)-D-propanylamino)-N-((S)-1-cyano-2-((S)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((5-Chloropyridin-3-yl)-D-propanylamino)-N-((S)-1-cyano-2-((R)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((5-Chloropyridin-3-yl)-D-propanylamino)-N-((R)-1-cyano-2-((S)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((5-Chloropyridin-3-yl)-D-propanylamino)-N-((R)-1-cyano-2-((R)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((5-Chloropyridin-3-yl)-L-propanylamino)-N-((S)-1-cyano-2-((S)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((5-Chloropyridin-3-yl)-L-propanylamino)-N-((S)-1-cyano-2-((R)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((5-Chloropyridin-3-yl)-L-propanylamino)-N-((R)-1-cyano-2-((S)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((5-Chloropyridin-3-yl)-L-propanylamino)-N-((R)-1-cyano-2-((R)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((5-Chloropyridin-3-yl)-D-propanylamino)-N-((S)-1-cyano-2-((S)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((5-Chloropyridin-3-yl)-D-propanylamino)-N-((S)-1-cyano-2-((R)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((5-Chloropyridin-3-yl)-D-propanylamino)-N-((R)-1-cyano-2-((S)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((5-Chloropyridin-3-yl)-D-propanylamino)-N-((R)-1-cyano-2-((R)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((5-Chloropyridin-3-yl)-L-propanylamino)-N-((S)-1-cyano-2-((S)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((5-Chloropyridin-3-yl)-L-propanylamino)-N-((S)-1-cyano-2-((R)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((5-Chloropyridin-3-yl)-L-propanylamino)-N-((R)-1-cyano-2-((S)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((5-Chloropyridin-3-yl)-L-propanylamino)-N-((R)-1-cyano-2-((R)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((5-Chloropyridin-3-yl)-D-propanylamino)-N-((S)-1-cyano-2-((S)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((5-Chloropyridin-3-yl)-D-propanylamino)-N-((S)-1-cyano-2-((R)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((5-Chloropyridin-3-yl)-D-propanylamino)-N-((R)-1-cyano-2-((S)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((5-Chloropyridin-3-yl)-D-propanylamino)-N-((R)-1-cyano-2-((R)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((5-Chloropyridin-3-yl)-L-propanylamino)-N-((S)-1-cyano-2-((S)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((5-Chloropyridin-3-yl)-L-propanylamino)-N-((S)-1-cyano-2-((R)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((5-Chloropyridin-3-yl)-L-propanylamino)-N-((R)-1-cyano-2-((S)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((5-Chloropyridin-3-yl)-L-propanylamino)-N-((R)-1-cyano-2-((R)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

2-((3-Chlorophenyl)-propanylamino)-N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 - azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-D-propanylamino)-N-((S)-1-cyano-2-((S)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-D-propanylamino)-N-((S)-1-cyano-2-((R)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-D-propanylamino)-N-((R)-1-cyano-2-((S)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-D-propanylamino)-N-((R)-1-cyano-2-((R)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-L-propanylamino)-N-((S)-1-cyano-2-((S)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-L-propanylamino)-N-((S)-1-cyano-2-((R)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-L-propanylamino)-N-((R)-1-cyano-2-((S)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-L-propanylamino)-N-((R)-1-cyano-2-((R)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-D-propanylamino)-N-((S)-1-cyano-2-((S)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-D-propanylamino)-N-((S)-1-cyano-2-((R)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-D-propanylamino)-N-((R)-1-cyano-2-((S)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-D-propanylamino)-N-((R)-1-cyano-2-((R)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-L-propanylamino)-N-((S)-1-cyano-2-((S)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-L-propanylamino)-N-((S)-1-cyano-2-((R)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-L-propanylamino)-N-((R)-1-cyano-2-((S)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-L-propanylamino)-N-((R)-1-cyano-2-((R)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-D-propanylamino)-N-((S)-1-cyano-2-((S)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-D-propanylamino)-N-((S)-1-cyano-2-((R)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-D-propanylamino)-N-((R)-1-cyano-2-((S)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-D-propanylamino)-N-((R)-1-cyano-2-((R)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-L-propanylamino)-N-((S)-1-cyano-2-((S)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-L-propanylamino)-N-((S)-1-cyano-2-((R)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-L-propanylamino)-N-((R)-1-cyano-2-((S)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-L-propanylamino)-N-((R)-1-cyano-2-((R)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-D-propanylamino)-N-((S)-1-cyano-2-((S)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-D-propanylamino)-N-((S)-1-cyano-2-((R)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-D-propanylamino)-N-((R)-1-cyano-2-((S)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-D-propanylamino)-N-((R)-1-cyano-2-((R)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-L-propanylamino)-N-((S)-1-cyano-2-((S)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-L-propanylamino)-N-((S)-1-cyano-2-((R)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-L-propanylamino)-N-((R)-1-cyano-2-((S)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-L-propanylamino)-N-((R)-1-cyano-2-((R)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-2-(3-cyclopropyl-2-((1-methyl-1H-pyrazole-4 -yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1S,3S,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1S,3S,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1S,3S,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1S,3S,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1S,3S,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1S,3S,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1S,3S,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1R,3S,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1R,3S,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1R,3S,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1R,3S,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1R,3S,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1R,3S,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1R,3S,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1R,3S,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1S,3R,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1S,3R,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1S,3R,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1S,3R,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1S,3R,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1S,3R,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1S,3R,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1S,3R,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1R,3R,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1R,3R,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1R,3R,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1R,3R,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1R,3R,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1R,3R,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1R,3R,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

(1R,3R,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide;

2-((3-Chloro-2-methylphenyl)glycyl)-N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-5,5 - Difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-N-((S)-1-cyano-2-((S)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-N-((S)-1-cyano-2-((R)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-N-((R)-1-cyano-2-((S)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-N-((R)-1-cyano-2-((R)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-N-((S)-1-cyano-2-((S)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-N-((S)-1-cyano-2-((R)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-N-((R)-1-cyano-2-((S)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-N-((R)-1-cyano-2-((R)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-N-((S)-1-cyano-2-((S)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-N-((S)-1-cyano-2-((R)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-N-((R)-1-cyano-2-((S)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-N-((R)-1-cyano-2-((R)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-N-((S)-1-cyano-2-((S)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-N-((S)-1-cyano-2-((R)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-N-((R)-1-cyano-2-((S)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-N-((R)-1-cyano-2-((R)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

2-(1-((3-chlorophenyl)amino)cyclopropane-1-carbonyl)-N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)- 5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-(1-((3-Chlorophenyl)amino)cyclopropane-1-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-(1-((3-Chlorophenyl)amino)cyclopropane-1-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-(1-((3-Chlorophenyl)amino)cyclopropane-1-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-(1-((3-Chlorophenyl)amino)cyclopropane-1-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-(1-((3-Chlorophenyl)amino)cyclopropane-1-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-(1-((3-Chlorophenyl)amino)cyclopropane-1-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-(1-((3-Chlorophenyl)amino)cyclopropane-1-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-(1-((3-Chlorophenyl)amino)cyclopropane-1-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-(1-((3-Chlorophenyl)amino)cyclopropane-1-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-(1-((3-Chlorophenyl)amino)cyclopropane-1-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-(1-((3-Chlorophenyl)amino)cyclopropane-1-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-(1-((3-Chlorophenyl)amino)cyclopropane-1-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-(1-((3-Chlorophenyl)amino)cyclopropane-1-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-(1-((3-Chlorophenyl)amino)cyclopropane-1-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-(1-((3-Chlorophenyl)amino)cyclopropane-1-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-(1-((3-Chlorophenyl)amino)cyclopropane-1-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl)-propanamidoyl)-2-azabicyclo [2.2.2] Octane-3-formamide;

(S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-D-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-L-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-D-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-L-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-D-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-L-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-D-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-L-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-D-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-L-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-D-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-L-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-D-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-L-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-D-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-L-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-L-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-L-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-D-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-L-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-D-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-L-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-D-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-L-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-D-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-L-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-D-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-L-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-D-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-L-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-D-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-L-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-D-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-(2-hydroxy-2-phenylacetyl)-2- Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((S)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((R)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((S)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((R)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((S)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((R)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((S)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((R)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((S)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((R)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((S)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((R)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((S)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((R)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((S)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((R)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((S)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((R)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((S)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((R)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((S)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((R)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((S)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((R)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((S)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((R)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((S)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((R)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((S)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((R)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((S)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((R)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

2-((3-chlorophenyl)-leucyl)-N-(1-cyano-2-(2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro- 2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-D-leucyl)-N-((S)-1-cyano-2-((S)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-D-leucyl)-N-((S)-1-cyano-2-((R)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-D-leucyl)-N-((R)-1-cyano-2-((S)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-D-leucyl)-N-((R)-1-cyano-2-((R)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-L-leucyl)-N-((S)-1-cyano-2-((S)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-L-leucyl)-N-((S)-1-cyano-2-((R)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-L-leucyl)-N-((R)-1-cyano-2-((S)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)-L-leucyl)-N-((R)-1-cyano-2-((R)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-D-leucyl)-N-((S)-1-cyano-2-((S)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-D-leucyl)-N-((S)-1-cyano-2-((R)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-D-leucyl)-N-((R)-1-cyano-2-((S)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-D-leucyl)-N-((R)-1-cyano-2-((R)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-L-leucyl)-N-((S)-1-cyano-2-((S)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-L-leucyl)-N-((S)-1-cyano-2-((R)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-L-leucyl)-N-((R)-1-cyano-2-((S)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((3-Chlorophenyl)-L-leucyl)-N-((R)-1-cyano-2-((R)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((3-Chlorophenyl)-D-leucyl)-N-((S)-1-cyano-2-((S)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((3-Chlorophenyl)-D-leucyl)-N-((S)-1-cyano-2-((R)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((3-Chlorophenyl)-D-leucyl)-N-((R)-1-cyano-2-((S)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((3-Chlorophenyl)-D-leucyl)-N-((R)-1-cyano-2-((R)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((3-Chlorophenyl)-L-leucyl)-N-((S)-1-cyano-2-((S)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((3-Chlorophenyl)-L-leucyl)-N-((S)-1-cyano-2-((R)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((3-Chlorophenyl)-L-leucyl)-N-((R)-1-cyano-2-((S)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((3-Chlorophenyl)-L-leucyl)-N-((R)-1-cyano-2-((R)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((3-Chlorophenyl)-D-leucyl)-N-((S)-1-cyano-2-((S)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((3-Chlorophenyl)-D-leucyl)-N-((S)-1-cyano-2-((R)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((3-Chlorophenyl)-D-leucyl)-N-((R)-1-cyano-2-((S)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((3-Chlorophenyl)-D-leucyl)-N-((R)-1-cyano-2-((R)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((3-Chlorophenyl)-L-leucyl)-N-((S)-1-cyano-2-((S)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((3-Chlorophenyl)-L-leucyl)-N-((S)-1-cyano-2-((R)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((3-Chlorophenyl)-L-leucyl)-N-((R)-1-cyano-2-((S)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((3-Chlorophenyl)-L-leucyl)-N-((R)-1-cyano-2-((R)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

N-(1-cyano-2-(2-oxopyrrolidin-3-yl)ethyl)-2-(3-cyclopropyl-2-((5-methylpyridin-3-yl)amine Base) propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3S,4S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3S,4S)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3S,4S)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3S,4S)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3S,4S)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3S,4S)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3S,4S)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3S,4R)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3S,4R)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3S,4R)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3S,4R)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3S,4R)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3S,4R)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3S,4R)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3S,4R)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3R,4S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3R,4S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3R,4S)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3R,4S)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3R,4S)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3R,4S)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3R,4S)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1S,3R,4S)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3R,4R)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3R,4R)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3R,4R)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3R,4R)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3R,4R)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3R,4R)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3R,4R)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

(1R,3R,4R)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide;

5,5-Difluoro-N-(4-fluoro-4-(methylsulfonyl)-1-(2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2 -(9-Hydroxy-9H-fen-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-5,5-Difluoro-N-((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3S,4S)-5,5-Difluoro-N-((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrole Pyridine-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3S,4S)-5,5-Difluoro-N-((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3S,4S)-5,5-Difluoro-N-((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3S,4S)-5,5-Difluoro-N-((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3S,4S)-5,5-Difluoro-N-((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3S,4S)-5,5-Difluoro-N-((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3S,4S)-5,5-Difluoro-N-((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3S,4R)-5,5-Difluoro-N-((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrole Pyridine-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3S,4R)-5,5-Difluoro-N-((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3S,4R)-5,5-Difluoro-N-((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrole Pyridine-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3S,4R)-5,5-Difluoro-N-((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3S,4R)-5,5-Difluoro-N-((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrole Pyridine-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3S,4R)-5,5-Difluoro-N-((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3S,4R)-5,5-Difluoro-N-((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3S,4R)-5,5-Difluoro-N-((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3R,4S)-5,5-Difluoro-N-((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3R,4S)-5,5-Difluoro-N-((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3R,4S)-5,5-Difluoro-N-((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3R,4S)-5,5-Difluoro-N-((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3R,4S)-5,5-Difluoro-N-((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3R,4S)-5,5-Difluoro-N-((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3R,4S)-5,5-Difluoro-N-((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3R,4S)-5,5-Difluoro-N-((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrole Pyridine-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3R,4R)-5,5-Difluoro-N-((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3R,4R)-5,5-Difluoro-N-((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3R,4R)-5,5-Difluoro-N-((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3R,4R)-5,5-Difluoro-N-((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3R,4R)-5,5-Difluoro-N-((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3R,4R)-5,5-Difluoro-N-((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3R,4R)-5,5-Difluoro-N-((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3R,4R)-5,5-Difluoro-N-((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

N-(4-fluoro-4-(methylsulfonyl)-1-(2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-(9-hydroxyl-9H -Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

2-(2-Acetamido-2-phenylacetyl)-N-(4-fluoro-4-(methylsulfonyl)-1-(2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((R,E)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((R,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((R,E)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((R,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((R,E)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((R,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((R,E)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((R,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((R,E)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((R,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((R,E)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((R,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((R,E)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((R,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((R,E)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((R,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

2-(3,3-Dimethyl-2-(2,2,2-trifluoroacetylamino)butyryl)-N-(4-fluoro-4-(methylsulfonyl)-1-( 2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

2-(3,3-Dimethyl-2-(2,2,2-trifluoroacetylamino)butyryl)-N-(4-fluoro-4-(methylsulfonyl)-1-( 2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide;

2-(3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N-(4-fluoro-4-(methylsulfonyl Acyl)-1-(2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N- ((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)eta Hydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide;

2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-(4-fluoro-4-(methylsulfonyl)-1-(2-oxopyrrolidine -3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3S,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3S,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3S,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3S,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3S,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3S,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3S,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3S,4R)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3S,4R)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3S,4R)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3S,4R)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3S,4R)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3S,4R)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3S,4R)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3S,4R)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3R,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3R,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3R,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3R,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3R,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3R,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3R,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3R,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3R,4R)-2-(7-chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3R,4R)-2-(7-chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3R,4R)-2-(7-chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3R,4R)-2-(7-chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3R,4R)-2-(7-chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3R,4R)-2-(7-chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3R,4R)-2-(7-chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3R,4R)-2-(7-chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-(4-fluoro-4-(methylsulfonyl)-1-(2-oxopyrrolidine -3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3S,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3S,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3S,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3S,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3S,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3S,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3S,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3S,4R)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3S,4R)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3S,4R)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3S,4R)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3S,4R)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3S,4R)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3S,4R)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3S,4R)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3R,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3R,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3R,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3R,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3R,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3R,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3R,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1S,3R,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3R,4R)-2-(7-chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3R,4R)-2-(7-chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3R,4R)-2-(7-chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3R,4R)-2-(7-chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3R,4R)-2-(7-chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3R,4R)-2-(7-chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3R,4R)-2-(7-chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

(1R,3R,4R)-2-(7-chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide;

2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-(4-fluoro-4-(methylsulfonyl)-1-(2-oxo Pyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1S,3S,4S)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1S,3S,4S)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1S,3S,4S)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1S,3S,4S)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1S,3S,4S)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1S,3S,4S)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1S,3S,4S)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1R,3S,4R)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1R,3S,4R)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1R,3S,4R)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1R,3S,4R)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1R,3S,4R)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1R,3S,4R)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1R,3S,4R)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1R,3S,4R)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1S,3R,4S)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1S,3R,4S)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1S,3R,4S)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1S,3R,4S)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1S,3R,4S)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1S,3R,4S)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1S,3R,4S)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1S,3R,4S)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1R,3R,4R)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1R,3R,4R)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1R,3R,4R)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1R,3R,4R)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1R,3R,4R)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1R,3R,4R)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1R,3R,4R)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

(1R,3R,4R)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide;

2-(3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N-(4-fluoro-4-(methylsulfonyl Acyl)-1-(2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-(3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N-((S , E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-nitrogen Heterobicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide;

4-(2-((3-Chlorophenyl)-D-leucylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamido)- Ethyl 2-fluoro-5-(2-oxopyrrolidin-3-yl)pent-2-enoate;

(S,Z)-4-((1S,3S,4S)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,Z)-4-((1S,3S,4S)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,Z)-4-((1S,3S,4S)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,Z)-4-((1S,3S,4S)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,Z)-4-((1R,3S,4R)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,Z)-4-((1R,3S,4R)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,Z)-4-((1R,3S,4R)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,Z)-4-((1R,3S,4R)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,Z)-4-((1S,3R,4S)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,Z)-4-((1S,3R,4S)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,Z)-4-((1S,3R,4S)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,Z)-4-((1S,3R,4S)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,Z)-4-((1R,3R,4R)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,Z)-4-((1R,3R,4R)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,Z)-4-((1R,3R,4R)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,Z)-4-((1R,3R,4R)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,E)-4-((1S,3S,4S)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,E)-4-((1S,3S,4S)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,E)-4-((1S,3S,4S)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,E)-4-((1S,3S,4S)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,E)-4-((1R,3S,4R)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,E)-4-((1R,3S,4R)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,E)-4-((1R,3S,4R)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,E)-4-((1R,3S,4R)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,E)-4-((1S,3R,4S)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,E)-4-((1S,3R,4S)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,E)-4-((1S,3R,4S)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,E)-4-((1S,3R,4S)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,E)-4-((1R,3R,4R)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,E)-4-((1R,3R,4R)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,E)-4-((1R,3R,4R)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,E)-4-((1R,3R,4R)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,Z)-4-((1S,3S,4S)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,Z)-4-((1S,3S,4S)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,Z)-4-((1S,3S,4S)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,Z)-4-((1S,3S,4S)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,Z)-4-((1R,3S,4R)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,Z)-4-((1R,3S,4R)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,Z)-4-((1R,3S,4R)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,Z)-4-((1R,3S,4R)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,Z)-4-((1S,3R,4S)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,Z)-4-((1S,3R,4S)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,Z)-4-((1S,3R,4S)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,Z)-4-((1S,3R,4S)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,Z)-4-((1R,3R,4R)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,Z)-4-((1R,3R,4R)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,Z)-4-((1R,3R,4R)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,Z)-4-((1R,3R,4R)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,E)-4-((1S,3S,4S)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,E)-4-((1S,3S,4S)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,E)-4-((1S,3S,4S)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,E)-4-((1S,3S,4S)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,E)-4-((1R,3S,4R)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,E)-4-((1R,3S,4R)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,E)-4-((1R,3S,4R)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,E)-4-((1R,3S,4R)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,E)-4-((1S,3R,4S)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,E)-4-((1S,3R,4S)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,E)-4-((1S,3R,4S)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,E)-4-((1S,3R,4S)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,E)-4-((1R,3R,4R)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,E)-4-((1R,3R,4R)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,E)-4-((1R,3R,4R)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(R,E)-4-((1R,3R,4R)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

4-(2-(3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2] Octane-3-formamido)-2-fluoro-5-(2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester;

(S,Z)-4-((1S,3S,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,Z)-4-((1S,3S,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,Z)-4-((1S,3S,4S)-2-((R)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,Z)-4-((1S,3S,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,Z)-4-((1R,3S,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,Z)-4-((1R,3S,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,Z)-4-((1R,3S,4R)-2-((R)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,Z)-4-((1R,3S,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,Z)-4-((1S,3R,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,Z)-4-((1S,3R,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,Z)-4-((1S,3R,4S)-2-((R)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,Z)-4-((1S,3R,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,Z)-4-((1R,3R,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,Z)-4-((1R,3R,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,Z)-4-((1R,3R,4R)-2-((R)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,Z)-4-((1R,3R,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,E)-4-((1S,3S,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,E)-4-((1S,3S,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,E)-4-((1S,3S,4S)-2-((R)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,E)-4-((1S,3S,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,E)-4-((1R,3S,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,E)-4-((1R,3S,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,E)-4-((1R,3S,4R)-2-((R)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,E)-4-((1R,3S,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,E)-4-((1S,3R,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,E)-4-((1S,3R,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,E)-4-((1S,3R,4S)-2-((R)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,E)-4-((1S,3R,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,E)-4-((1R,3R,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,E)-4-((1R,3R,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,E)-4-((1R,3R,4R)-2-((R)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(S,E)-4-((1R,3R,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,Z)-4-((1S,3S,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,Z)-4-((1S,3S,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,Z)-4-((1S,3S,4S)-2-((R)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,Z)-4-((1S,3S,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,Z)-4-((1R,3S,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,Z)-4-((1R,3S,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,Z)-4-((1R,3S,4R)-2-((R)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,Z)-4-((1R,3S,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,Z)-4-((1S,3R,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,Z)-4-((1S,3R,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,Z)-4-((1S,3R,4S)-2-((R)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,Z)-4-((1S,3R,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,Z)-4-((1R,3R,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,Z)-4-((1R,3R,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,Z)-4-((1R,3R,4R)-2-((R)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,Z)-4-((1R,3R,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,E)-4-((1S,3S,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,E)-4-((1S,3S,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,E)-4-((1S,3S,4S)-2-((R)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,E)-4-((1S,3S,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,E)-4-((1R,3S,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,E)-4-((1R,3S,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,E)-4-((1R,3S,4R)-2-((R)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,E)-4-((1R,3S,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,E)-4-((1S,3R,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,E)-4-((1S,3R,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,E)-4-((1S,3R,4S)-2-((R)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,E)-4-((1S,3R,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,E)-4-((1R,3R,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,E)-4-((1R,3R,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,E)-4-((1R,3R,4R)-2-((R)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

(R,E)-4-((1R,3R,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate;

2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-(4-fluoro-4-(methylsulfonyl)-1-(2- Oxypyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((S,E)-4-fluoro-4 -(Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide;

(1S,3S,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((S,E)-4-fluoro-4 -(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide;

(1S,3S,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4 -(Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide;

(1S,3S,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4 -(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide;

(1S,3S,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((R,E)-4-fluoro-4 -(Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide;

(1S,3S,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((R,E)-4-fluoro-4 -(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide;

(1S,3S,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4 -(Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide;

(1S,3S,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4 -(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide;

(1R,3S,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((S,E)-4-fluoro-4 -(Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide;

(1R,3S,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((S,E)-4-fluoro-4 -(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide;

(1R,3S,4R)-2-((3-chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4 -(Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide;

(1R,3S,4R)-2-((3-chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4 -(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide;

(1R,3S,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((R,E)-4-fluoro-4 -(Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide;

(1R,3S,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((R,E)-4-fluoro-4 -(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide;

(1R,3S,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4 -(Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide;

(1R,3S,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4 -(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide;

(1S,3R,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((S,E)-4-fluoro-4 -(Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide;

(1S,3R,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((S,E)-4-fluoro-4 -(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide;

(1S,3R,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4 -(Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide;

(1S,3R,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4 -(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide;

(1S,3R,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((R,E)-4-fluoro-4 -(Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide;

(1S,3R,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((R,E)-4-fluoro-4 -(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide;

(1S,3R,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4 -(Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide;

(1S,3R,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4 -(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide;

(1R,3R,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((S,E)-4-fluoro-4 -(Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide;

(1R,3R,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((S,E)-4-fluoro-4 -(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide;

(1R,3R,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4 -(Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide;

(1R,3R,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4 -(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide;

(1R,3R,4R)-2-((3-chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((R,E)-4-fluoro-4 -(Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide;

(1R,3R,4R)-2-((3-chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((R,E)-4-fluoro-4 -(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide;

(1R,3R,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4 -(Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide;

(1R,3R,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4 -(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide;

2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-(4-fluoro-4-(methylsulfonyl)-1-(2-oxopyrrolidine- 3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methylsulfonyl Acyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3S,4S)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methylsulfonyl Acyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3S,4S)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methylsulfonyl Acyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3S,4S)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methylsulfonyl Acyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3S,4S)-2-((3-Chlorophenyl)glycinyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methylsulfonyl Acyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3S,4S)-2-((3-Chlorophenyl)glycinyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methylsulfonyl Acyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3S,4S)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methylsulfonyl Acyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3S,4S)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methylsulfonyl Acyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3S,4R)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methylsulfonyl Acyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3S,4R)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methylsulfonyl Acyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3S,4R)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methylsulfonyl Acyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3S,4R)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methylsulfonyl Acyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3S,4R)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methylsulfonyl Acyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3S,4R)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methylsulfonyl Acyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3S,4R)-2-((3-Chlorophenyl)glycinyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methylsulfonyl Acyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3S,4R)-2-((3-Chlorophenyl)glycinyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methylsulfonyl Acyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3R,4S)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methylsulfonyl Acyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3R,4S)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methylsulfonyl Acyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3R,4S)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methylsulfonyl Acyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3R,4S)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methylsulfonyl Acyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3R,4S)-2-((3-Chlorophenyl)glycinyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methylsulfonyl Acyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3R,4S)-2-((3-Chlorophenyl)glycinyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methylsulfonyl Acyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3R,4S)-2-((3-Chlorophenyl)glycinyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methylsulfonyl Acyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1S,3R,4S)-2-((3-Chlorophenyl)glycinyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methylsulfonyl Acyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3R,4R)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methylsulfonyl Acyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3R,4R)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methylsulfonyl Acyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3R,4R)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methylsulfonyl Acyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3R,4R)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methylsulfonyl Acyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3R,4R)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methylsulfonyl Acyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3R,4R)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methylsulfonyl Acyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3R,4R)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methylsulfonyl Acyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

(1R,3R,4R)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methylsulfonyl Acyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine;

8-(4-fluoro-1H-indole-2-carbonyl)-N-(4-fluoro-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl )-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide;

8-(4-fluoro-1H-indole-2-carbonyl)-N-((S)-4-fluoro-3-oxo-1-((S)-2-oxopyrrolidine-3- Base) butane-2-yl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide;

(S)-8-(4-fluoro-1H-indole-2-carbonyl)-N-((S)-4-fluoro-3-oxo-1-((S)-2-oxopyrrole Pyridin-3-yl)butan-2-yl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide;

(S)-8-(4-fluoro-1H-indole-2-carbonyl)-N-((S)-4-fluoro-3-oxo-1-((R)-2-oxopyrrole Pyridin-3-yl)butan-2-yl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide;

(S)-8-(4-fluoro-1H-indole-2-carbonyl)-N-((R)-4-fluoro-3-oxo-1-((S)-2-oxopyrrole Pyridin-3-yl)butan-2-yl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide;

(S)-8-(4-fluoro-1H-indole-2-carbonyl)-N-((R)-4-fluoro-3-oxo-1-((R)-2-oxopyrrole Pyridin-3-yl)butan-2-yl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide;

(R)-8-(4-fluoro-1H-indole-2-carbonyl)-N-((S)-4-fluoro-3-oxo-1-((S)-2-oxopyrrole Pyridin-3-yl)butan-2-yl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide;

(R)-8-(4-fluoro-1H-indole-2-carbonyl)-N-((S)-4-fluoro-3-oxo-1-((R)-2-oxopyrrole Pyridin-3-yl)butan-2-yl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide;

(R)-8-(4-fluoro-1H-indole-2-carbonyl)-N-((R)-4-fluoro-3-oxo-1-((S)-2-oxopyrrole Pyridin-3-yl)butan-2-yl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide;

(R)-8-(4-fluoro-1H-indole-2-carbonyl)-N-((R)-4-fluoro-3-oxo-1-((R)-2-oxopyrrole Pyridin-3-yl)butan-2-yl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide;

8-(7-Chloro-1H-indole-2-carbonyl)-N-(4-fluoro-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl )-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide;

8-(7-Chloro-1H-indole-2-carbonyl)-N-((S)-4-fluoro-3-oxo-1-((S)-2-oxopyrrolidine-3- Base) butane-2-yl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide;

(S)-8-(7-chloro-1H-indole-2-carbonyl)-N-((S)-4-fluoro-3-oxo-1-((S)-2-oxopyrrole Pyridin-3-yl)butan-2-yl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide;

(S)-8-(7-chloro-1H-indole-2-carbonyl)-N-((S)-4-fluoro-3-oxo-1-((R)-2-oxopyrrole Pyridin-3-yl)butan-2-yl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide;

(S)-8-(7-chloro-1H-indole-2-carbonyl)-N-((R)-4-fluoro-3-oxo-1-((S)-2-oxopyrrole Pyridin-3-yl)butan-2-yl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide;

(S)-8-(7-chloro-1H-indole-2-carbonyl)-N-((R)-4-fluoro-3-oxo-1-((R)-2-oxopyrrole Pyridin-3-yl)butan-2-yl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide;

(R)-8-(7-chloro-1H-indole-2-carbonyl)-N-((S)-4-fluoro-3-oxo-1-((S)-2-oxopyrrole Pyridin-3-yl)butan-2-yl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide;

(R)-8-(7-chloro-1H-indole-2-carbonyl)-N-((S)-4-fluoro-3-oxo-1-((R)-2-oxopyrrole Pyridin-3-yl)butan-2-yl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide;

(R)-8-(7-chloro-1H-indole-2-carbonyl)-N-((R)-4-fluoro-3-oxo-1-((S)-2-oxopyrrole Pyridin-3-yl)butan-2-yl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide;

(R)-8-(7-chloro-1H-indole-2-carbonyl)-N-((R)-4-fluoro-3-oxo-1-((R)-2-oxopyrrole Pyridin-3-yl)butan-2-yl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide;

2-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-5,5-difluoro-N-(4-fluoro-3-oxo-1-(2-oxo Pyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-5,5-difluoro-N-((S)-4-fluoro- 3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1S,3S,4S)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-5,5-difluoro-N-((S)-4-fluoro- 3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1S,3S,4S)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-5,5-difluoro-N-((R)-4-fluoro- 3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1S,3S,4S)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-5,5-difluoro-N-((R)-4-fluoro- 3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1R,3S,4R)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-5,5-difluoro-N-((S)-4-fluoro- 3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1R,3S,4R)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-5,5-difluoro-N-((S)-4-fluoro- 3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1R,3S,4R)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-5,5-difluoro-N-((R)-4-fluoro- 3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1R,3S,4R)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-5,5-difluoro-N-((R)-4-fluoro- 3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1S,3R,4S)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-5,5-difluoro-N-((S)-4-fluoro- 3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1S,3R,4S)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-5,5-difluoro-N-((S)-4-fluoro- 3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1S,3R,4S)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-5,5-difluoro-N-((R)-4-fluoro- 3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1S,3R,4S)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-5,5-difluoro-N-((R)-4-fluoro- 3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1R,3R,4R)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-5,5-difluoro-N-((S)-4-fluoro- 3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1R,3R,4R)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-5,5-difluoro-N-((S)-4-fluoro- 3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1R,3R,4R)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-5,5-difluoro-N-((R)-4-fluoro- 3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

(1R,3R,4R)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-5,5-difluoro-N-((R)-4-fluoro- 3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ;

2-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-N-(4-fluoro-3-oxo-1-(2-oxopyrrolidin-3-yl) )butane-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-N-((S)-4-fluoro-3-oxo-1 -((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-N-((S)-4-fluoro-3-oxo-1 -((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-N-((R)-4-fluoro-3-oxo-1 -((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-N-((R)-4-fluoro-3-oxo-1 -((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-N-((S)-4-fluoro-3-oxo-1 -((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-N-((S)-4-fluoro-3-oxo-1 -((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-N-((R)-4-fluoro-3-oxo-1 -((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-N-((R)-4-fluoro-3-oxo-1 -((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-N-((S)-4-fluoro-3-oxo-1 -((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-N-((S)-4-fluoro-3-oxo-1 -((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-N-((R)-4-fluoro-3-oxo-1 -((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-N-((R)-4-fluoro-3-oxo-1 -((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-N-((S)-4-fluoro-3-oxo-1 -((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-N-((S)-4-fluoro-3-oxo-1 -((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-N-((R)-4-fluoro-3-oxo-1 -((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-N-((R)-4-fluoro-3-oxo-1 -((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

2-(2-(3-fluorophenyl)-2,2-difluoroacetyl)-N-(4-fluoro-3-oxo-1-(2-oxopyrrolidin-3-yl) )butane-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-(2-(3-fluorophenyl)-2,2-difluoroacetyl)-N-((S)-4-fluoro-3-oxo-1 -((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-(2-(3-fluorophenyl)-2,2-difluoroacetyl)-N-((S)-4-fluoro-3-oxo-1 -((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-(2-(3-fluorophenyl)-2,2-difluoroacetyl)-N-((R)-4-fluoro-3-oxo-1 -((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-(2-(3-fluorophenyl)-2,2-difluoroacetyl)-N-((R)-4-fluoro-3-oxo-1 -((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-(2-(3-fluorophenyl)-2,2-difluoroacetyl)-N-((S)-4-fluoro-3-oxo-1 -((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-(2-(3-fluorophenyl)-2,2-difluoroacetyl)-N-((S)-4-fluoro-3-oxo-1 -((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-(2-(3-fluorophenyl)-2,2-difluoroacetyl)-N-((R)-4-fluoro-3-oxo-1 -((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-(2-(3-fluorophenyl)-2,2-difluoroacetyl)-N-((R)-4-fluoro-3-oxo-1 -((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-(2-(3-fluorophenyl)-2,2-difluoroacetyl)-N-((S)-4-fluoro-3-oxo-1 -((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-(2-(3-fluorophenyl)-2,2-difluoroacetyl)-N-((S)-4-fluoro-3-oxo-1 -((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-(2-(3-fluorophenyl)-2,2-difluoroacetyl)-N-((R)-4-fluoro-3-oxo-1 -((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-(2-(3-fluorophenyl)-2,2-difluoroacetyl)-N-((R)-4-fluoro-3-oxo-1 -((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-(2-(3-fluorophenyl)-2,2-difluoroacetyl)-N-((S)-4-fluoro-3-oxo-1 -((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-(2-(3-fluorophenyl)-2,2-difluoroacetyl)-N-((S)-4-fluoro-3-oxo-1 -((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-(2-(3-fluorophenyl)-2,2-difluoroacetyl)-N-((R)-4-fluoro-3-oxo-1 -((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-(2-(3-fluorophenyl)-2,2-difluoroacetyl)-N-((R)-4-fluoro-3-oxo-1 -((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

2-(2-Fluoro-2-(3-fluorophenyl)propionyl)-N-(4-fluoro-3-oxo-1-(2-oxopyrrolidin-3-yl)butane -2-yl) octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-(2-fluoro-2-(3-fluorophenyl)propionyl)-N-((S)-4-fluoro-3-oxo-1-(( S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((S)-4-fluoro-3-oxo- 1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((S)-4-fluoro-3-oxo- 1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((R)-4-fluoro-3-oxo- 1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((S)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((R)-4-fluoro-3-oxo- 1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((S)-4-fluoro-3-oxo- 1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((S)-4-fluoro-3-oxo- 1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((R)-4-fluoro-3-oxo- 1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-((R)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((R)-4-fluoro-3-oxo- 1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((S)-4-fluoro-3-oxo- 1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((S)-4-fluoro-3-oxo- 1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((R)-4-fluoro-3-oxo- 1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((S)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((R)-4-fluoro-3-oxo- 1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((S)-4-fluoro-3-oxo- 1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((S)-4-fluoro-3-oxo- 1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((R)-4-fluoro-3-oxo- 1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-((R)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((R)-4-fluoro-3-oxo- 1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((S)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((S)-4-fluoro-3-oxo- 1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((S)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((S)-4-fluoro-3-oxo- 1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((S)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((R)-4-fluoro-3-oxo- 1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((S)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((R)-4-fluoro-3-oxo- 1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((S)-4-fluoro-3-oxo- 1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((S)-4-fluoro-3-oxo- 1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((R)-4-fluoro-3-oxo- 1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-((R)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((R)-4-fluoro-3-oxo- 1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((S)-4-fluoro-3-oxo- 1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((S)-4-fluoro-3-oxo- 1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((R)-4-fluoro-3-oxo- 1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((S)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((R)-4-fluoro-3-oxo- 1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((S)-4-fluoro-3-oxo- 1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((S)-4-fluoro-3-oxo- 1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((R)-4-fluoro-3-oxo- 1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-((R)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((R)-4-fluoro-3-oxo- 1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-(1-(2-oxodihydrofuran-3(2H)-ylidene)- 3-(2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((S,E)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1S,3S,4S)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((S,E)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((R)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1S,3S,4S)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((S,Z)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1S,3S,4S)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((S,Z)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((R)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1S,3S,4S)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((R,E)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1S,3S,4S)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((R,E)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((R)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1S,3S,4S)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((R,Z)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1S,3S,4S)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((R,Z)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((R)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1R,3S,4R)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((S,E)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1R,3S,4R)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((S,E)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((R)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1R,3S,4R)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((S,Z)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1R,3S,4R)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((S,Z)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((R)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1R,3S,4R)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((R,E)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((S)-2-oxopyrrolidin-3-yl)propane-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1R,3S,4R)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((R,E)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((R)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1R,3S,4R)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((R,Z)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((S)-2-oxopyrrolidin-3-yl)propane-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1R,3S,4R)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((R,Z)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((R)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1S,3R,4S)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((S,E)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1S,3R,4S)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((S,E)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((R)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1S,3R,4S)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((S,Z)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1S,3R,4S)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((S,Z)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((R)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1S,3R,4S)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((R,E)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((S)-2-oxopyrrolidin-3-yl)propane-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1S,3R,4S)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((R,E)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((R)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1S,3R,4S)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((R,Z)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((S)-2-oxopyrrolidin-3-yl)propane-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1S,3R,4S)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((R,Z)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((R)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1R,3R,4R)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((S,E)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1R,3R,4R)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((S,E)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((R)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1R,3R,4R)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((S,Z)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1R,3R,4R)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((S,Z)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((R)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1R,3R,4R)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((R,E)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1R,3R,4R)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((R,E)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((R)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1R,3R,4R)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((R,Z)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((S)-2-oxopyrrolidin-3-yl)propane-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

(1R,3R,4R)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((R,Z)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((R)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides;

2-(2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-5,5- Difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-(2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((S)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((S)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((S)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((S)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((R)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((R)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((R)-2-Bromo-9-hydroxyl-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-2-((R)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((S)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((S)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((S)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((S)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((R)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((R)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((R)-2-Bromo-9-hydroxyl-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-2-((R)-2-Bromo-9-hydroxyl-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((S)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((S)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((S)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((S)-2-Bromo-9-hydroxyl-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((R)-2-Bromo-9-hydroxyl-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((R)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((R)-2-Bromo-9-hydroxyl-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-2-((R)-2-Bromo-9-hydroxyl-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((S)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((S)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((S)-2-Bromo-9-hydroxyl-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((S)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((R)-2-Bromo-9-hydroxyl-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((R)-2-Bromo-9-hydroxyl-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((R)-2-bromo-9-hydroxyl-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-2-((R)-2-bromo-9-hydroxyl-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-2-(2,7-difluoro-9-hydroxy-9H-fennel-9-carbonyl)-5 ,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1S,3S,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Fluoro-9-hydroxy-9H-fluorene-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Fluoro-9-hydroxy-9H-fluorene-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Fluoro-9-hydroxy-9H-fluorene-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Fluoro-9-hydroxy-9H-fluorene-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Fluoro-9-hydroxy-9H-fluorene-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Fluoro-9-hydroxy-9H-fluorene-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Fluoro-9-hydroxy-9H-fluorene-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Fluoro-9-hydroxy-9H-fluorene-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Fluoro-9-hydroxy-9H-fluorene-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Fluoro-9-hydroxy-9H-fluorene-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Fluoro-9-hydroxy-9H-fluorene-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Fluoro-9-hydroxy-9H-fluorene-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Fluoro-9-hydroxy-9H-fluorene-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Fluoro-9-hydroxy-9H-fluorene-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Fluoro-9-hydroxy-9H-fluorene-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Fluoro-9-hydroxy-9H-fluorene-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-2-(2,7-dichloro-9-hydroxy-9H-fennel-9-carbonyl)-5 ,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamide;

(1S,3S,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Chloro-9-hydroxy-9H-fennel-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Chloro-9-hydroxy-9H-fennel-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Chloro-9-hydroxy-9H-fennel-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3S,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Chloro-9-hydroxy-9H-fennel-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Chloro-9-hydroxy-9H-fennel-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Chloro-9-hydroxy-9H-fennel-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Chloro-9-hydroxy-9H-fennel-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3S,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Chloro-9-hydroxy-9H-fennel-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Chloro-9-hydroxy-9H-fennel-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Chloro-9-hydroxy-9H-fennel-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Chloro-9-hydroxy-9H-fennel-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1S,3R,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Chloro-9-hydroxy-9H-fennel-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Chloro-9-hydroxy-9H-fennel-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Chloro-9-hydroxy-9H-fennel-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Chloro-9-hydroxy-9H-fennel-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

(1R,3R,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Chloro-9-hydroxy-9H-fennel-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide;

N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-(9-hydroxy-9H-fennel-9-carbonyl)octahydro Cyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-(4-fluoro-1H-indole-2-carbonyl)eta Hydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(4-fluoro-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(4-fluoro-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(4-fluoro-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(4-fluoro-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(4-fluoro-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(4-fluoro-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(4-fluoro-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(4-fluoro-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(4-fluoro-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(4-fluoro-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(4-fluoro-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(4-fluoro-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(4-fluoro-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(4-fluoro-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(4-fluoro-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(4-fluoro-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoromethyl)-6-fluoro-1H-indole-2-carbonyl )-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoromethyl)-7-chloro-1H-indole-2-carbonyl )-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-2-(4,7-difluoro-6-chloro-1H-indole-2-carbonyl)- 5,5-Difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

2-(3-Chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl) -5,5-Difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-(3-Chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-1-cyano-2-((S )-2-oxopiperidin-3-yl)ethyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-(3-Chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-1-cyano-2-((R )-2-oxopiperidin-3-yl)ethyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-1-cyano-2-((S )-2-oxopiperidin-3-yl)ethyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-1-cyano-2-((R )-2-oxopiperidin-3-yl)ethyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-(3-Chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-1-cyano-2-((S )-2-oxopiperidin-3-yl)ethyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-(3-Chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-1-cyano-2-((R )-2-oxopiperidin-3-yl)ethyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-1-cyano-2-((S )-2-oxopiperidin-3-yl)ethyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-2-(3-Chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-1-cyano-2-((R )-2-oxopiperidin-3-yl)ethyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-1-cyano-2-((S )-2-oxopiperidin-3-yl)ethyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-1-cyano-2-((R )-2-oxopiperidin-3-yl)ethyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-1-cyano-2-((S )-2-oxopiperidin-3-yl)ethyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-1-cyano-2-((R )-2-oxopiperidin-3-yl)ethyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-1-cyano-2-((S )-2-oxopiperidin-3-yl)ethyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-1-cyano-2-((R )-2-oxopiperidin-3-yl)ethyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-1-cyano-2-((S )-2-oxopiperidin-3-yl)ethyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-1-cyano-2-((R )-2-oxopiperidin-3-yl)ethyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-2-(4,6-difluoro-7-chloro-1H-indole-2-carbonyl)- 5,5-Difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,6-di Fluoro-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,6-di Fluoro-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,6-di Fluoro-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,6-di Fluoro-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,6-di Fluoro-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,6-di Fluoro-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,6-di Fluoro-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,6-di Fluoro-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,6-di Fluoro-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,6-di Fluoro-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,6-di Fluoro-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,6-di Fluoro-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,6-di Fluoro-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,6-di Fluoro-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,6-di Fluoro-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,6-di Fluoro-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-6-methyl-7-chloro-1H-indole-2-carbonyl )-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-6 -Methyl-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-6 -Methyl-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-6 -Methyl-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-6 -Methyl-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-6 -Methyl-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-6 -Methyl-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-6 -Methyl-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-6 -Methyl-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-6 -Methyl-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-6 -Methyl-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-6 -Methyl-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-6 -Methyl-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-6 -Methyl-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-6 -Methyl-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-6 -Methyl-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-6 -Methyl-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-2-(4,7-difluoro-6-methyl-1H-indole-2-carbonyl) -5,5-Difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-methyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-methyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-methyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-methyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-methyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-methyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-methyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-methyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-methyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-methyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-methyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-methyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-methyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-methyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-methyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-methyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-7-difluoromethyl-1H-indole-2-carbonyl)- 5,5-Difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-7 -Difluoromethyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-7 -Difluoromethyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-7 -Difluoromethyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-7 -Difluoromethyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-7 -Difluoromethyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-7 -Difluoromethyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-7 -Difluoromethyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-7 -Difluoromethyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-7 -Difluoromethyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-7 -Difluoromethyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-7 -Difluoromethyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-7 -Difluoromethyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-7 -Difluoromethyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-7 -Difluoromethyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-7 -Difluoromethyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-7 -Difluoromethyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

N-(1-cyano-2-(2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy-1H-indole-2-carbonyl)-5,5-di Fluoroctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy -1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy -1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy -1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy -1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy -1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy -1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy -1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy -1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy -1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy -1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy -1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy -1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy -1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy -1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy -1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy -1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide;

N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-4,4-difluoro-2-(9-hydroxy-9H-fennel-9-carbonyl)octahydro Cyclopenta[c]pyrrole-1-carboxamide;

N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-4,4-difluoro-2-(9-hydroxyl-9H- Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

N-(1-cyano-2-(2-oxopyrrolidin-3-yl)ethyl)-4,4-difluoro-2-(9-hydroxy-9H-fennel-9-carbonyl)octahydro Cyclopenta[c]pyrrole-1-carboxamide;

N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-4,4-difluoro-2-(9-hydroxyl-9H- Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-2-(9-hydroxy-9H-fenflure-9-carbonyl)octahydrocyclopenta[c]pyrrole- 1-formamide;

N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(9-hydroxyl-9H-fennel-9-carbonyl)octa Hydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(9-hydroxyl-9H -Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(9-hydroxyl-9H -Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(9-hydroxyl-9H -Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(9-hydroxyl-9H -Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(9-hydroxyl-9H -Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(9-hydroxyl-9H -Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(9-hydroxyl-9H -Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1S,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(9-hydroxyl-9H -Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(9-hydroxyl-9H -Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(9-hydroxyl-9H -Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(9-hydroxyl-9H -Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(9-hydroxyl-9H -Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(9-hydroxyl-9H -Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(9-hydroxyl-9H -Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide;

(1R,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(9-hydroxyl-9H -Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; and

(1R,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(9-hydroxyl-9H -Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide.

Embodiment 29 provides a pharmaceutical composition, which includes at least one compound according to any one of Embodiments 1-28 and a pharmaceutically acceptable carrier.

Embodiment 30 provides the pharmaceutical composition described in Embodiment 29, further comprising at least one additional agent for treating, improving and/or preventing coronavirus infection.

Embodiment 31 provides the pharmaceutical composition of embodiment 30, wherein the at least one additional agent is an inhibitor of RNA-dependent RNA polymerase (RdRp) (ie, nspl2) or a prodrug thereof.

Embodiment 32 provides a method for treating, improving and/or preventing coronavirus infection in a subject, the method comprising administering to the subject a therapeutically effective amount of at least one compound described in any one of Embodiments 1-28 and /or at least one pharmaceutical composition according to any one of embodiments 29-31.

Embodiment 33 provides the method of embodiment 32, wherein at least one additional agent for treating, ameliorating and/or preventing coronavirus infection is further administered to the subject.

Embodiment 34 provides the method of embodiment 33, wherein the at least one additional agent and the at least one compound and/or composition are co-administered to the subject.

Embodiment 35 provides the method of embodiment 34, wherein the at least one additional agent is an inhibitor of RNA-dependent RNA polymerase (RdRp) (ie, nspl2) or a prodrug thereof.

Embodiment 36 provides the method of embodiment 34 or 35, wherein at least one additional agent and at least one compound and/or composition are co-formulated.

Embodiment 37 provides the method of any one of embodiments 32-36, wherein the coronavirus is selected from an alphacoronavirus and a betacoronavirus.

Embodiment 38 provides the method of embodiment 37, wherein the alphacoronavirus is selected from human coronavirus 229E (HCoV-229E) and human coronavirus NL63 (HCoV-NL63).

Embodiment 39 provides the method described in embodiment 38, wherein the beta coronavirus is selected from severe acute respiratory syndrome-associated coronavirus 2 (SARS-CoV-2), severe acute respiratory syndrome-associated coronavirus 1 (SARS-CoV or SARS-CoV-1), Middle East respiratory syndrome-related coronavirus (MERS-CoV), human coronavirus OC43 (HCoV-OC43), and human coronavirus HKU1 (HCoV-HKU1).

Embodiment 40 provides the method of embodiment 37 or 39, wherein the betacoronavirus is SARS-CoV-2.

Embodiment 41 provides the method of any one of embodiments 32-40, wherein the coronavirus main protease (M ^pro ) is inhibited.

Embodiment 42 provides the method of embodiment 41, wherein M ^pro is 3C-like protease (3CL ^pro ).

Embodiment 43 provides the method of any one of embodiments 32-42, wherein the subject is a mammal.

Embodiment 44 provides the method of embodiment 43, wherein the mammal is a human.

The terms and expressions used herein are used as terms of description rather than limitation, and The use of these terms and expressions is not intended to exclude any equivalents to the features shown and described, or parts thereof, but it will be recognized that various modifications may be made within the scope of the embodiments of the application. Accordingly, it is to be understood that while this application describes specific embodiments and optional features, that modifications and variations of the compositions, methods and concepts disclosed herein may be employed by one of ordinary skill in the art, and that such modifications and variations are considered to be within the scope of the embodiments of the present application.

Claims (44)

A compound of formula (I), or a salt, solvate, geometric isomer, stereoisomer, tautomer or any mixture thereof:

in: R ¹ is selected from

,

,

,

,

R ^2a and R ^2b are each independently selected from H, optionally substituted C ₁ -C ₁₂ alkyl, optionally substituted C ₃ -C ₁₂ cycloalkyl, optionally substituted C ₂ -C ₁₂ hetero Cyclic and C ₇ -C ₁₂ aralkyl, wherein R ^2a and R ^A and one or more of R ^2a and R ^2b may be combined with the atoms to which they are bonded to form an optionally substituted C _3- C ₁₂ heterocyclyl or an optionally substituted C ₃ -C ₁₂ cycloalkyl, wherein two optional substituents thereof can combine with the atoms to which they are bonded to form optionally substituted C ₃ -C ₁₂ cycloalkyl, optionally substituted C ₂ -C ₁₂ heterocyclyl or optionally substituted phenyl; ^R3 is

; L is selected from optionally substituted C ₁ -C ₃ alkylene, -C(=O)-*, -C(=O)(optionally substituted C ₁ -C ₂ alkylene)-*, -(optionally substituted C ₁ -C ₂ alkylene)-C(=O)-* and a bond, wherein * represents the bond between L and R ^4a ; R ^4a is selected from optionally substituted phenyl, optionally substituted C ₂ -C ₉ heteroaryl,

Wherein in R ^4a , optionally substituted phenyl or optionally substituted C ₂ -C ₉ heteroaryl is substituted by at least one halogen; R ^4b is H; R ^4c is selected from

,

and

; R ^5a is selected from H, -C(=O) (optionally substituted C ₁ -C ₆ alkyl), -C(=O) (C ₁ -C ₆ haloalkyl) and optionally substituted C ₁ -C ₆ alkyl; R ^5b is selected from H, optionally substituted C ₁ -C ₆ alkyl and optionally substituted C ₂ -C ₆ alkenyl; ^R is selected from H and halogen; R ^6a is selected from H, optionally substituted C ₁ -C ₆ alkyl and optionally substituted phenyl; ^R6b is H, or R ^6a and R ^6b are combined with the carbon atoms to which they are bonded to form an optionally substituted C ₃ -C ₈ cycloalkyl; R ^6c is selected from C(=O) (optionally substituted C ₁ -C ₆ haloalkyl), C(=O) (optionally substituted C ₁ -C ₆ alkyl), optionally substituted C ₂ -C _Heteroaryl and optionally substituted phenyl; R ^7a and R ^7b if present are each independently selected from H, halogen, OR ^B , optionally substituted C ₁ -C ₆ alkyl, optionally substituted C ₃ -C ₈ cycloalkyl, optionally substituted C ₂ -C ₉ heterocyclyl and optionally substituted naphthyl; R ^a1 , R ^a2 , R ^a3 , R ^a4 , R ^a5 , R ^a6 , R ^a7 , R ^a8 , R ^{a9 ,} and R ^a10 , if present, are each independently selected from H, halogen, CN, NO ₂ , optional Optionally substituted C ₁ -C ₆ alkyl, optionally substituted C ₃ -C ₈ cycloalkyl, optionally substituted C ₁ -C ₆ alkoxy, optionally substituted C ₃ -C ₈ ring Alkoxy, optionally substituted C ₂ -C ₈ heterocycloalkyl, optionally substituted phenyl, optionally substituted naphthyl, optionally substituted C ₂ -C ₉ heteroaryl, OR ^B , N(R ^B )(R ^C ), NO ₂ , C(=O)N(R ^B )(R ^C ), C(=O)R ^B , C(=O)OR ^B , OC(=O )R ^B , OC(=O)OR ^B , SR ^B , S(=O)R ^B , S(=O) ₂ R ^B , N(R ^B )S(=O) ₂ R ^C , N(R ^B )C(=O)R ^C and S(=O) ₂ N(R ^B )(R ^C ); R ^b1 , R ^b2 and R ^b3 , if present, are each independently selected from H, halogen, optionally substituted C ₁ -C ₆ alkyl, optionally substituted C ₃ -C ₈ cycloalkyl, optionally Optionally substituted C ₁ -C ₆ alkoxy, optionally substituted C ₃ -C ₈ cycloalkoxy, optionally substituted C ₂ -C ₈ heterocycloalkyl, optionally substituted phenyl , optionally substituted naphthyl, optionally substituted C ₂ -C ₉ heteroaryl, C(=O)N(R ^B )(R ^C ), C(= ^O )RB , C(=O )OR ^B , S(=O) ^RB , S(=O) ₂ R ^B and S(=O) ₂ N( ^RB )(R ^C ), wherein two pairs of substituents selected from R ^b1 , R ^b2 and R ^b3 can be combined with the carbon atoms to which they are bonded to form an optionally substituted C ₂ -C ₈ heterocycloalkyl or an optionally substituted C ₃ -C ₈ cycloalkyl; R ^c1 , R ^c2 , R ^c3 , R ^c4 , R ^c5 , R ^c6 , R ^c7 , R ^c8 , R ^c9 , R ^c10 and R ^c11 , if present, are each independently selected from H, halogen, CN, _NO , optionally substituted C ₁ -C ₆ alkyl, optionally substituted C ₃ -C ₈ cycloalkyl, optionally substituted C ₁ -C ₆ alkoxy, optionally substituted C ₃ - C ₈ cycloalkoxy, heterocyclyl, phenyl, naphthyl, heteroaryl, OR ^B , N(R ^B )(R ^C ), NO ₂ , C(=O)N(R ^B )(R ^C ), C(=O)R ^B , C(=O)OR ^B , OC(=O)R ^B , OC(=O)OR ^B , SR ^B , S(=O)R ^B , S(=O) ₂ R ^B , N(R ^B )S(=O) ₂ R ^C , N(R ^B )C(=O)R ^C and S(=O) ₂ N(R ^B )(R ^C ); Each occurrence of R ^A , R ^B and R ^C is independently selected from H, -C(=O) (optionally substituted C ₁ -C ₆ alkyl), -C(=O) (optionally substituted C ₁ -C ₆ haloalkyl), optionally substituted C ₁ -C ₆ alkyl, optionally substituted C ₁ -C ₃ haloalkyl, optionally substituted C ₃ -C ₈ cycloalkyl, Optionally substituted C ₁ -C ₆ alkoxy and optionally substituted C ₃ -C ₈ cycloalkoxy, optionally substituted phenyl, optionally substituted naphthyl and optionally substituted C ₂ -C ₉ heteroaryl; ^RD is selected from H, -C( ⁼ O) ^RB and -S(=O) _2RB ; R ^E is selected from H, C ₁ -C ₆ alkyl and C ₁ -C ₆ haloalkyl; each occurrence of X is independently selected from O, S and N( ^RB ); Y, if present, is selected from I, Br, Cl, F and OR ^D ; Z ^and Z are ^each independently selected from H and halogen; and Wherein if ^R is 4-methoxy- 1H -indolyl, at least one of the following applies: (a) R ^2a is not isopropyl and R ^2b is not H, (b) R ^2a is not H and R ^2b is not isopropyl, or (c) R ^4a is not -C(=O)CH ₂ OH or -C(=O)CH ₂ OP(=O)(OH) ₂ . The compound as claimed in item 1, which is selected from:

The compound as claimed in claim 1 or 2, wherein R ^2a and R ^2b in one selected from methyl, ethyl, n-propyl, isopropyl, cyclopropyl, cyclopropylmethyl, n-butyl, Second butyl, third butyl, cyclobutyl, methylcyclobutyl, n-pentyl, second pentyl, third pentyl, neopentyl, cyclopentyl, cyclopentylmethyl, n-hexyl , second hexyl, third hexyl, neohexyl, cyclohexyl and cyclohexylmethyl. The compound according to any one of claims 1 to 3, wherein one of R ^2a and R ^2b is H. The compound as claimed in item 1, which is selected from:

in: R ⁸ is selected from H, optionally substituted C ₁ -C ₆ alkyl, optionally substituted C ₂ -C ₆ alkenyl, optionally substituted C ₃ -C ₈ cycloalkyl, optionally substituted C ₂ -C ₉ heterocyclyl, optionally substituted phenyl, optionally substituted naphthyl, optionally substituted C ₂ -C ₉ heteroaryl, wherein each of the optionally substituted C ₁ -C ₆ alkyl, the optionally substituted C ₂ -C ₉ heteroaryl and the optionally substituted phenyl is optionally selected from the group consisting of C ₁ -C ₆ alkyl , C ₁ -C ₆ alkoxy and optionally substituted pyridyl by at least one substituent; and R ^d1 , R ^d2 , R ^d3 , R d4 , R ^d5 , R ^d6 , R ^{d7 ,} R ^d8 , R ^d9 and ^Rd10 , if present, each occurrence is independently selected from H, halogen, CN, _NO2 , optionally substituted _C1 - _C6 alkyl, optionally substituted _C3 - _C8 cycloalkyl, Optionally substituted C ₁ -C ₆ alkoxy, optionally substituted C ₃ -C ₈ cycloalkoxy, heterocyclyl, phenyl, naphthyl, heteroaryl, OR ^B , N(R ^B )(R ^C ), NO ₂ , C(=O)N(R ^B )(R ^C ), C(=O)R ^B , C(=O)OR ^B , OC(=O)R ^B , OC( =O)OR ^B , SR ^B , S(=O)R ^B , S(=O) ₂ R ^B , N(R ^B )S(=O) ₂ R ^C , N(R ^B )C(=O) R ^C and S(=O) ₂ N(R ^B )(R ^C ), wherein two substituents selected from R ^d1 , R ^d2 , R ^d3 , R ^d4 , R ^d5 , R ^d6 , R ^d7 , R ^d8 , R ^d9 and R ^d10 can be combined with the atoms to which they are bonded to form a Optionally substituted C ₃ -C ₈ cycloalkyl or optionally substituted C ₂ -C ₈ heterocycloalkyl. The compound according to any one of claims 1 and 3 to 5, selected from:

The compound as described in Claim 5 or 6, wherein at least one of the following applies: (a) if present, each of ^Rd1 , ^Rd2 , ^Rd3 , ^Rd4 , ^Rd5 , ^Rd6 , ^Rd7 , ^Rd8 , ^Rd9 , and ^Rd10 is H; (b) if present, nine of ^Rd1 , ^Rd2 , ^Rd3 , ^Rd4 , ^Rd5 , ^Rd6 , ^Rd7 , ^Rd8 , ^Rd9 and ^Rd10 are H; (c) if present, eight of ^Rd1 , ^Rd2 , ^Rd3 , ^Rd4 , ^Rd5 , ^Rd6 , ^Rd7 , ^Rd8 , ^Rd9 and ^Rd10 are H; (d) if present, seven of ^Rd1 , ^Rd2 , ^Rd3 , ^Rd4 , ^Rd5 , ^Rd6 , ^Rd7 , ^Rd8 , ^Rd9 and ^Rd10 are H; (e) if present, six of ^Rd1 , ^Rd2 , ^Rd3 , ^Rd4 , ^Rd5 , ^Rd6 , ^Rd7 , ^Rd8 , ^Rd9 and ^Rd10 are H; (f) if present, five of ^Rd1 , ^Rd2 , ^Rd3 , ^Rd4 , ^Rd5 , ^Rd6 , ^Rd7 , ^Rd8 , ^Rd9 and ^Rd10 are H; (g) if present, four of ^Rd1 , ^Rd2 , ^Rd3 , ^Rd4 , ^Rd5 , ^Rd6 , ^Rd7 , ^Rd8 , ^Rd9 and ^Rd10 are H; (h) if present, three of ^Rd1 , ^Rd2 , ^Rd3 , ^Rd4 , ^Rd5 , ^Rd6 , ^Rd7 , ^Rd8 , ^Rd9 and ^Rd10 are H; (i) if present, two of ^Rd1 , ^Rd2 , ^Rd3 , ^Rd4 , ^Rd5 , ^Rd6 , ^Rd7 , ^{Rd8 ,} Rd9 and ^Rd10 are H; and (j) If present, one of ^Rd1 , ^Rd2 , ^Rd3 , ^Rd4 , ^Rd5 , ^Rd6 , ^Rd7 , ^Rd8 , ^Rd9 and ^Rd10 is H. The compound according to any one of claims 1 and 3 to 7, selected from:

The compound according to any one of claims 1 to 8, wherein R ^a1 , R ^a2 , R ^a3 , R ^a4 , R ^a5 , R ^a6 , R ^a7 , R ^a8 , R ^a9 and R ^a10 , if present, are independently is selected from H, Me, Br, Cl, F, OMe and _CF2H . The compound as described in any one of claims 1 to 9, wherein at least one of the following applies: (a) if present, each of R ^a1 , R ^a2 , R ^a3 , R ^a4 , R ^a5 , R ^a6 , R ^a7 , R ^a8 , R ^a9 and R ^a10 is H; (b) if present, nine of R ^a1 , R ^a2 , R ^a3 , R ^a4 , R ^a5 , R ^a6 , R ^a7 , R ^a8 , R ^a9 and R ^a10 are H; (c) if present, eight of R ^a1 , R ^a2 , R ^a3 , R ^a4 , R ^a5 , R ^a6 , R ^a7 , R ^a8 , R ^a9 and R ^a10 are H; (d) if present, seven of R ^a1 , R ^a2 , R ^a3 , R ^a4 , R ^a5 , R ^a6 , R ^a7 , R ^a8 , R ^a9 and R ^a10 are H; (e) if present, six of R ^a1 , R ^a2 , R ^a3 , R ^a4 , R ^a5 , R ^a6 , R ^a7 , R ^a8 , R ^a9 and R ^a10 are H; (f) if present, five of R ^a1 , R ^a2 , R ^a3 , R ^a4 , R ^a5 , R ^a6 , R ^a7 , R ^a8 , R ^a9 and R ^a10 are H; (g) if present, four of R ^a1 , R ^a2 , R ^a3 , R ^a4 , R ^a5 , R ^a6 , R ^a7 , R ^a8 , R ^a9 and R ^a10 are H; (h) if present, three of R ^a1 , R ^a2 , R ^a3 , R ^a4 , R ^a5 , R ^a6 , R ^a7 , R ^a8 , R ^a9 and R ^a10 are H; (i) if present, two of R ^a1 , R ^a2 , R ^a3 , R ^a4 , R ^a5 , R ^a6 , R ^a7 , R ^a8 , R ^a9 and R ^a10 are H; and (j) If present, one of R ^a1 , R ^a2 , R ^a3 , R ^a4 , R ^a5 , R ^a6 , R ^a7 , R ^a8 , R ^a9 and R ^a10 is H. The compound as described in any one of claims 1 to 8, wherein ^R is selected from:

The compound according to any one of claims 1 to 8 and 11, wherein R ^6a is selected from H, methyl, isobutyl, tert-butyl, cyclopropylmethyl, cyclobutylmethyl and phenyl. The compound as claimed in any one of claims 1 to 8 and 11, wherein R ^6a and R ^6b combine with the carbon atoms to which they are bonded to form a cyclopropyl group. The compound as claimed in any one of claims 1 to 8 and 11 to 13, wherein R ^6c is selected from C(=O)CF ₃ , C(=O)CH ₃ , is selected from C ₁ -C ₆ alkyl Pyridyl substituted with at least one substituent of halogen, pyrazolyl substituted with at least one substituent selected from C ₁ -C ₆ alkyl and halogen, and at least one substituent selected from C ₁ -C ₆ alkyl and halogen Substituent substituted phenyl. The compound according to any one of claims 1 to 8 and 11 to 14, wherein R ^6c is selected from C(=O)CF ₃ , C(=O)CH ₃ ,

,

,

,

The compound as claimed in any one of claims 1 to 10, wherein R ^7a and R ^7b are each independently selected from H, OH, Me, cyclopentyl and F. The compound according to any one of claims 1 to 16, wherein ^R is selected from:

The compound according to any one of claims 1 to 17, wherein ^R is selected from:

The compound according to any one of claims 1 to 18, wherein L is a bond. The compound according to any one of claims 1 to 19, wherein ^R is selected from:

The compound as described in any one of claims 1 to 20, wherein at least one of the following applies: (a) if present, each of ^Rc1 , ^Rc2 , ^Rc3 , ^Rc4 , ^Rc5 , ^Rc6 , ^Rc7 , ^Rc8 , ^Rc9 , ^Rc10 and ^Rc11 is H; (b) if present, ten of ^Rc1 , ^Rc2 , ^Rc3 , ^Rc4 , ^Rc5 , ^Rc6 , ^Rc7 , ^Rc8 , ^Rc9 , ^Rc10 and ^Rc11 are H; (c) if present, nine of R ^c1 , R ^c2 , R ^c3 , R ^c4 , R ^c5 , R ^c6 , R ^c7 , R ^c8 , R ^c9 , R ^c10 and R ^c11 are H; (d) if present, eight of ^Rc1 , ^Rc2 , ^Rc3 , ^Rc4 , ^Rc5 , ^Rc6 , ^Rc7 , ^Rc8 , ^Rc9 , ^Rc10 and ^Rc11 are H; (e) if present, seven of ^Rc1 , ^Rc2 , ^Rc3 , ^Rc4 , ^Rc5 , ^Rc6 , ^Rc7 , ^Rc8 , ^Rc9 , ^Rc10 and ^Rc11 are H; (f) if present, six of R ^c1 , R ^c2 , R ^c3 , R ^c4 , R ^c5 , R ^c6 , R ^c7 , R ^c8 , R ^c9 , R ^c10 and R ^c11 are H; (g) if present, five of R ^c1 , R ^c2 , R ^c3 , R ^c4 , R ^c5 , R ^c6 , R ^c7 , R ^c8 , R ^c9 , R ^c10 and R ^c11 are H; (h) if present, four of R ^c1 , R ^c2 , R ^c3 , R ^c4 , R ^c5 , R ^c6 , R ^c7 , R ^c8 , R ^c9 , R ^c10 and R ^c11 are H; (i) if present, three of R ^c1 , R ^c2 , R ^c3 , R ^c4 , R ^c5 , R ^c6 , R ^c7 , R ^c8 , R ^c9 , R ^c10 and R ^c11 are H; (j) if present, two of R ^c1 , R ^c2 , R ^c3 , R ^c4 , R ^c5 , R ^c6 , R ^c7 , R ^c8 , R ^c9 , R ^c10 and R ^c11 are H; and (k) If present, one of R ^c1 , R ^c2 , R ^c3 , R ^c4 , R ^c5 , R ^c6 , R ^c7 , R ^c8 , R ^c9 , R ^c10 and R ^c11 ) is H. The compound as described in any one of claims 1 to 21, wherein at least one of the following applies: (a) if present, each of R ^b1 , R ^b2 and R ^b3 is H; (b) if present, two of R ^b1 , R ^b2 and R ^b3 are H; and (c) If present, one of R ^b1 , R ^b2 and R ^b3 is H. The compound as described in any one of claims 1 to 22, wherein R ^4a is selected from CN, CHO,

,

,

,

,

,

,

The compound as described in any one of claims 1 to 23, wherein R ^4c is selected from

,

,

,

,

and

. The compound according to any one of claims 1 to 24, wherein ^R is selected from

,

,

,

,

,

,

,

The compound according to any one of claims 1 to 25, wherein each occurrence of optionally substituted alkyl, optionally substituted cycloalkyl and optionally substituted heterocycloalkyl is independently selectable is substituted by at least one of the following: C ₁ -C ₆ alkyl, C ₃ -C ₈ cycloalkyl, C ₁ -C ₆ hydroxyalkyl, halogen, CN, OR ^I , N(R ^I )(R ^II ), C ₁ -C ₆ alkoxy, C ₃ -C ₈ cycloalkoxy, C ₁ -C ₆ haloalkoxy, C ₃ -C ₈ halocycloalkoxy, optionally substituted phenyl , optionally substituted C ₂ -C ₉ heteroaryl, C(=O)R ^I , C(=O)OR ^I , OC(=O)R ^I , OC(=O)OR ^I , SR ^I , S(=O)R ^I , S(=O) ₂ R ^I , S(=O) ₂ N(R ^I )(R ^II ), S(=O) ₂ NR ^I C(=O)NHR ^II , N (R ^I )S(=O) ₂ R ^II , N(R ^I )C(=O)R ^II and C(=O)NR ^I R ^II , wherein R ^I and R ^II are each independently selected from H, - C(=O)(C ₁ -C ₆ alkyl), -C(=O)(C ₁ -C ₆ haloalkyl), C ₁ -C ₆ alkyl, C ₁ -C ₃ haloalkyl, C ₃ - C ₈ cycloalkyl, C ₁ -C ₆ alkoxy and C ₃ -C ₈ cycloalkoxy, phenyl, naphthyl and C ₂ -C ₉ heteroaryl. The compound according to any one of claims 1 to 26, wherein optionally substituted phenyl, optionally substituted naphthyl, optionally substituted heterocyclic and optionally substituted heteroaryl Each occurrence is independently optionally substituted with at least one substituent selected from the group consisting of C ₁ -C ₆ alkyl, C ₃ -C ₈ cycloalkyl, phenyl, C ₁ -C ₆ hydroxyalkyl, C ₁ -C ₆ alkoxy, C ₃ -C ₈ cycloalkoxy, C ₁ -C ₆ haloalkyl, C ₁ -C ₆ haloalkoxy, C ₃ -C ₈ halocycloalkoxy, halogen, CN, OR ^I , N(R ^I )(R ^II ), NO ₂ , C(=O)N(R ^I )(R ^II ), C(=O)R ^I , C(=O)OR ^I , OC(= O)R ^I , OC(=O)OR ^I , SR ^I , S(=O)R ^I , S(=O) ₂ R ^I , N(R ^I )S(=O) ₂ R ^II , N(R ^I ) C(=O)R ^II and S(=O) ₂ N(R ^I )(R ^II ), wherein R ^I and R ^II are each independently selected from H, -C(=O)(C ₁ -C ₆ alkyl), -C(=O)(C ₁ -C ₆ haloalkyl), C ₁ -C ₆ alkyl, C ₁ -C ₃ haloalkyl, C ₃ -C ₈ cycloalkyl, C ₁ -C ₆ alkoxy and C ₃ -C ₈ cycloalkoxy, phenyl, naphthyl and C ₂ -C ₉ heteroaryl. The compound according to any one of claims 1 to 27, selected from: N-(3-cyclohexyl-1-oxo-1-((1-oxo-3-(2-oxopyrrolidin-3-yl)propan-2-yl)amino)propane-2 -base)- N-(3-cyclohexyl-1-oxo-1-((1-oxo-3-(2-oxopyrrolidin-3-yl)propan-2-yl)amino)propane-2 -yl)-9-hydroxyl-9H-stilbene-9-formamide; N-((S)-3-cyclohexyl-1-oxo-1-(((S)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl) Propan-2-yl)amino)propan-2-yl)-9-hydroxyl-9H-tila-9-carboxamide; N-((S)-3-cyclohexyl-1-oxo-1-(((S)-1-oxo-3-((R)-2-oxopyrrolidin-3-yl) Propan-2-yl)amino)propan-2-yl)-9-hydroxyl-9H-tila-9-carboxamide; N-((S)-3-cyclohexyl-1-oxo-1-(((R)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl) Propan-2-yl)amino)propan-2-yl)-9-hydroxyl-9H-tila-9-carboxamide; N-((S)-3-cyclohexyl-1-oxo-1-(((R)-1-oxo-3-((R)-2-oxopyrrolidin-3-yl) Propan-2-yl)amino)propan-2-yl)-9-hydroxyl-9H-tila-9-carboxamide; N-((R)-3-cyclohexyl-1-oxo-1-(((S)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl) Propan-2-yl)amino)propan-2-yl)-9-hydroxyl-9H-tila-9-carboxamide; N-((R)-3-cyclohexyl-1-oxo-1-(((S)-1-oxo-3-((R)-2-oxopyrrolidin-3-yl) Propan-2-yl)amino)propan-2-yl)-9-hydroxyl-9H-tila-9-carboxamide; N-((R)-3-cyclohexyl-1-oxo-1-(((R)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl) Propan-2-yl)amino)propan-2-yl)-9-hydroxyl-9H-tila-9-carboxamide; N-((R)-3-cyclohexyl-1-oxo-1-(((R)-1-oxo-3-((R)-2-oxopyrrolidin-3-yl) Propan-2-yl)amino)propan-2-yl)-9-hydroxyl-9H-tila-9-carboxamide; N-(4-(cyclopropylamino)-3,4-dioxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)-2-(2-hydroxyl-2 , 2-diphenylacetamido)-4-methylpentanamide; (S)-N-((S)-4-(cyclopropylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2 -yl)-2-(2-hydroxy-2,2-diphenylacetamido)-4-methylpentanamide; (S)-N-((S)-4-(cyclopropylamino)-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2 -yl)-2-(2-hydroxy-2,2-diphenylacetamido)-4-methylpentanamide; (S)-N-((R)-4-(cyclopropylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2 -yl)-2-(2-hydroxy-2,2-diphenylacetamido)-4-methylpentanamide; (S)-N-((R)-4-(cyclopropylamino)-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2 -yl)-2-(2-hydroxy-2,2-diphenylacetamido)-4-methylpentanamide; (R)-N-((S)-4-(cyclopropylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2 -yl)-2-(2-hydroxy-2,2-diphenylacetamido)-4-methylpentanamide; (R)-N-((S)-4-(cyclopropylamino)-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2 -yl)-2-(2-hydroxy-2,2-diphenylacetamido)-4-methylpentanamide; (R)-N-((R)-4-(cyclopropylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2 -yl)-2-(2-hydroxy-2,2-diphenylacetamido)-4-methylpentanamide; (R)-N-((R)-4-(cyclopropylamino)-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2 -yl)-2-(2-hydroxy-2,2-diphenylacetamido)-4-methylpentanamide; N-(3-cyclohexyl-1-((4-hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)amino)-1-oxo Propan-2-yl)-9-hydroxyl-9H-oxo-9-carboxamide; N-((S)-3-cyclohexyl-1-(((S)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-formamide; N-((S)-3-cyclohexyl-1-(((S)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-formamide; N-((S)-3-cyclohexyl-1-(((R)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-formamide; N-((S)-3-cyclohexyl-1-(((R)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-formamide; N-((R)-3-cyclohexyl-1-(((S)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-formamide; N-((R)-3-cyclohexyl-1-(((S)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-formamide; N-((R)-3-cyclohexyl-1-(((R)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-formamide; N-((R)-3-cyclohexyl-1-(((R)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-formamide; N-(4-Hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)-1-(9-hydroxy-9H-oxo-9-carbonyl) -4-Phenylpiperidine

-2-Formamide; (S)-N-((S)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-1-( 9-Hydroxy-9H-terpinene-9-carbonyl)-4-phenylpiperene

-2-Formamide; (S)-N-((S)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-1-( 9-Hydroxy-9H-terpinene-9-carbonyl)-4-phenylpiperene

-2-Formamide; (S)-N-((R)-4-hydroxyl-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-1-( 9-Hydroxy-9H-terpinene-9-carbonyl)-4-phenylpiperene

-2-Formamide; (S)-N-((R)-4-hydroxyl-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-1-( 9-Hydroxy-9H-terpinene-9-carbonyl)-4-phenylpiperene

-2-Formamide; (R)-N-((S)-4-hydroxyl-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-1-( 9-Hydroxy-9H-terpinene-9-carbonyl)-4-phenylpiperene

-2-Formamide; (R)-N-((S)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-1-( 9-Hydroxy-9H-terpinene-9-carbonyl)-4-phenylpiperene

-2-Formamide; (R)-N-((R)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-1-( 9-Hydroxy-9H-terpinene-9-carbonyl)-4-phenylpiperene

-2-Formamide; (R)-N-((R)-4-hydroxyl-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-1-( 9-Hydroxy-9H-terpinene-9-carbonyl)-4-phenylpiperene

-2-Formamide; 9-Hydroxy-N-(4-methyl-1-((4-(methylamino)-3,4-dioxo-1-(2-oxopyrrolidin-3-yl)butane-2- Base) amino)-1-oxopentan-2-yl)-9H-stilbene-9-carboxamide; 9-Hydroxy-N-((S)-4-methyl-1-(((S)-4-(methylamino)-3,4-dioxo-1-((S)-2-oxo Pyrrolidin-3-yl)butan-2-yl)amino)-1-oxopentan-2-yl)-9H-oxo-9-carboxamide; 9-Hydroxy-N-((S)-4-methyl-1-(((S)-4-(methylamino)-3,4-dioxo-1-((R)-2-oxo Pyrrolidin-3-yl)butan-2-yl)amino)-1-oxopentan-2-yl)-9H-oxo-9-carboxamide; 9-Hydroxy-N-((S)-4-methyl-1-(((R)-4-(methylamino)-3,4-dioxo-1-((S)-2-oxo Pyrrolidin-3-yl)butan-2-yl)amino)-1-oxopentan-2-yl)-9H-oxo-9-carboxamide; 9-Hydroxy-N-((S)-4-methyl-1-(((R)-4-(methylamino)-3,4-dioxo-1-((R)-2-oxo Pyrrolidin-3-yl)butan-2-yl)amino)-1-oxopentan-2-yl)-9H-oxo-9-carboxamide; 9-Hydroxy-N-((R)-4-methyl-1-(((S)-4-(methylamino)-3,4-dioxo-1-((S)-2-oxo Pyrrolidin-3-yl)butan-2-yl)amino)-1-oxopentan-2-yl)-9H-oxo-9-carboxamide; 9-Hydroxy-N-((R)-4-methyl-1-(((S)-4-(methylamino)-3,4-dioxo-1-((R)-2-oxo Pyrrolidin-3-yl)butan-2-yl)amino)-1-oxopentan-2-yl)-9H-oxo-9-carboxamide; 9-Hydroxy-N-((R)-4-methyl-1-(((R)-4-(methylamino)-3,4-dioxo-1-((S)-2-oxo Pyrrolidin-3-yl)butan-2-yl)amino)-1-oxopentan-2-yl)-9H-oxo-9-carboxamide; 9-Hydroxy-N-((R)-4-methyl-1-(((R)-4-(methylamino)-3,4-dioxo-1-((R)-2-oxo Pyrrolidin-3-yl)butan-2-yl)amino)-1-oxopentan-2-yl)-9H-oxo-9-carboxamide; N-(1-((4-(ethylamino)-3,4-dioxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)amino)-4-methanol Base-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide; N-((S)-1-(((S)-4-(ethylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-formamide; N-((S)-1-(((S)-4-(ethylamino)-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-formamide; N-((S)-1-(((R)-4-(ethylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-formamide; N-((S)-1-(((R)-4-(ethylamino)-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-formamide; N-((R)-1-(((S)-4-(ethylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-formamide; N-((R)-1-(((S)-4-(ethylamino)-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-formamide; N-((R)-1-(((R)-4-(ethylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-formamide; N-((R)-1-(((R)-4-(ethylamino)-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-formamide; N-(1-((1-(4-chlorothiazol-2-yl)-1-oxo-3-(2-oxopyrrolidin-3-yl)propan-2-yl)amino)- 4-Methyl-1-oxopentan-2-yl)-4-methoxy-1H-indole-2-carboxamide; N-((S)-1-(((S)-1-(4-chlorothiazol-2-yl)-1-oxo-3-((S)-2-oxopyrrolidine-3- Base) propan-2-yl) amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1H-indole-2-carboxamide; N-((S)-1-(((S)-1-(4-chlorothiazol-2-yl)-1-oxo-3-((R)-2-oxopyrrolidine-3- Base) propan-2-yl) amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1H-indole-2-carboxamide; N-((S)-1-(((R)-1-(4-chlorothiazol-2-yl)-1-oxo-3-((S)-2-oxopyrrolidine-3- Base) propan-2-yl) amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1H-indole-2-carboxamide; N-((S)-1-(((R)-1-(4-chlorothiazol-2-yl)-1-oxo-3-((R)-2-oxopyrrolidine-3- Base) propan-2-yl) amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1H-indole-2-carboxamide; N-((R)-1-(((S)-1-(4-chlorothiazol-2-yl)-1-oxo-3-((S)-2-oxopyrrolidine-3- Base) propan-2-yl) amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1H-indole-2-carboxamide; N-((R)-1-(((S)-1-(4-chlorothiazol-2-yl)-1-oxo-3-((R)-2-oxopyrrolidine-3- Base) propan-2-yl) amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1H-indole-2-carboxamide; N-((R)-1-(((R)-1-(4-chlorothiazol-2-yl)-1-oxo-3-((S)-2-oxopyrrolidine-3- Base) propan-2-yl) amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1H-indole-2-carboxamide; N-((R)-1-(((R)-1-(4-chlorothiazol-2-yl)-1-oxo-3-((R)-2-oxopyrrolidine-3- Base) propan-2-yl) amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1H-indole-2-carboxamide; N-(3-cyclohexyl-1-((4-(methylamino)-3,4-dioxo-1-(2-oxopyrrolidin-3-yl)butan-2-yl)amino )-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide; N-((S)-3-cyclohexyl-1-(((S)-4-(methylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidine-3 -yl)butane-2-yl)amino)-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide; N-((S)-3-cyclohexyl-1-(((S)-4-(methylamino)-3,4-dioxo-1-((R)-2-oxopyrrolidine-3 -yl)butane-2-yl)amino)-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide; N-((S)-3-cyclohexyl-1-(((R)-4-(methylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidine-3 -yl)butane-2-yl)amino)-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide; N-((S)-3-cyclohexyl-1-(((R)-4-(methylamino)-3,4-dioxo-1-((R)-2-oxopyrrolidine-3 -yl)butane-2-yl)amino)-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide; N-((R)-3-cyclohexyl-1-(((S)-4-(methylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidine-3 -yl)butane-2-yl)amino)-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide; N-((R)-3-cyclohexyl-1-(((S)-4-(methylamino)-3,4-dioxo-1-((R)-2-oxopyrrolidine-3 -yl)butane-2-yl)amino)-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide; N-((R)-3-cyclohexyl-1-(((R)-4-(methylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidine-3 -yl)butane-2-yl)amino)-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide; N-((R)-3-cyclohexyl-1-(((R)-4-(methylamino)-3,4-dioxo-1-((R)-2-oxopyrrolidine-3 -yl)butane-2-yl)amino)-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide; N-(1-((4-amino-3,4-dioxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)amino)-3-cyclohexyl-1 -Oxopropan-2-yl)-9-hydroxy-9H-oxo-9-carboxamide; N-((S)-1-(((S)-4-amino-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2- Base) amino)-3-cyclohexyl-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide; N-((S)-1-(((S)-4-amino-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2- Base) amino)-3-cyclohexyl-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide; N-((S)-1-(((R)-4-amino-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2- Base) amino)-3-cyclohexyl-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide; N-((S)-1-(((R)-4-amino-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2- Base) amino)-3-cyclohexyl-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide; N-((R)-1-(((S)-4-amino-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2- Base) amino)-3-cyclohexyl-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide; N-((R)-1-(((S)-4-amino-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2- Base) amino)-3-cyclohexyl-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide; N-((R)-1-(((R)-4-amino-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2- Base) amino)-3-cyclohexyl-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide; N-((R)-1-(((R)-4-amino-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2- Base) amino)-3-cyclohexyl-1-oxopropan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide; N-(1-((4-(cyclopropylamino)-3,4-dioxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)amino)-4 -Methyl-1-oxopentan-2-yl)-9-hydroxy-9H-stilbene-9-carboxamide; N-((S)-1-(((S)-4-(cyclopropylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl) Butane-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide; N-((S)-1-(((S)-4-(cyclopropylamino)-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl) Butane-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide; N-((S)-1-(((R)-4-(cyclopropylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl) Butane-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide; N-((S)-1-(((R)-4-(cyclopropylamino)-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl) Butane-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide; N-((R)-1-(((S)-4-(cyclopropylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl) Butane-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide; N-((R)-1-(((S)-4-(cyclopropylamino)-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl) Butane-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide; N-((R)-1-(((R)-4-(cyclopropylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl) Butane-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide; N-((R)-1-(((R)-4-(cyclopropylamino)-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl) Butane-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide; (3aR,6aS)-N-(4-Hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)-2-(4-methoxy- 1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (3aS,6aR)-N-(4-Hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)-2-(4-methoxy- 1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; N-(1-((4-amino-3,4-dioxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)amino)-4-methyl-1 -Oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide; N-((S)-1-(((S)-4-amino-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2- Base) amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide; N-((S)-1-(((S)-4-amino-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2- Base) amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide; N-((S)-1-(((R)-4-amino-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2- Base) amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide; N-((S)-1-(((R)-4-amino-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2- Base) amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide; N-((R)-1-(((S)-4-amino-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2- Base) amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide; N-((R)-1-(((S)-4-amino-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2- Base) amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide; N-((R)-1-(((R)-4-amino-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2- Base) amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide; N-((R)-1-(((R)-4-amino-3,4-dioxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2- Base) amino)-4-methyl-1-oxopentan-2-yl)-9-hydroxyl-9H-stilbene-9-carboxamide; N-(1-((1-(4-chlorothiazol-2-yl)-1-oxo-3-(2-oxopyrrolidin-3-yl)propan-2-yl)amino)- 3-cyclohexyl-1-oxopropan-2-yl)-4-methoxy-1H-indole-2-carboxamide; N-((S)-1-(((S)-1-(4-chlorothiazol-2-yl)-1-oxo-3-((S)-2-oxopyrrolidine-3- Base) propan-2-yl) amino)-3-cyclohexyl-1-oxopropan-2-yl)-4-methoxy-1H-indole-2-carboxamide; N-((S)-1-(((S)-1-(4-chlorothiazol-2-yl)-1-oxo-3-((R)-2-oxopyrrolidine-3- Base) propan-2-yl) amino)-3-cyclohexyl-1-oxopropan-2-yl)-4-methoxy-1H-indole-2-carboxamide; N-((S)-1-(((R)-1-(4-chlorothiazol-2-yl)-1-oxo-3-((S)-2-oxopyrrolidine-3- Base) propan-2-yl) amino)-3-cyclohexyl-1-oxopropan-2-yl)-4-methoxy-1H-indole-2-carboxamide; N-((S)-1-(((R)-1-(4-chlorothiazol-2-yl)-1-oxo-3-((R)-2-oxopyrrolidine-3- Base) propan-2-yl) amino)-3-cyclohexyl-1-oxopropan-2-yl)-4-methoxy-1H-indole-2-carboxamide; N-((R)-1-(((S)-1-(4-chlorothiazol-2-yl)-1-oxo-3-((S)-2-oxopyrrolidine-3- Base) propan-2-yl) amino)-3-cyclohexyl-1-oxopropan-2-yl)-4-methoxy-1H-indole-2-carboxamide; N-((R)-1-(((S)-1-(4-chlorothiazol-2-yl)-1-oxo-3-((R)-2-oxopyrrolidine-3- Base) propan-2-yl) amino)-3-cyclohexyl-1-oxopropan-2-yl)-4-methoxy-1H-indole-2-carboxamide; N-((R)-1-(((R)-1-(4-chlorothiazol-2-yl)-1-oxo-3-((S)-2-oxopyrrolidine-3- Base) propan-2-yl) amino)-3-cyclohexyl-1-oxopropan-2-yl)-4-methoxy-1H-indole-2-carboxamide; N-((R)-1-(((R)-1-(4-chlorothiazol-2-yl)-1-oxo-3-((R)-2-oxopyrrolidine-3- Base) propan-2-yl) amino)-3-cyclohexyl-1-oxopropan-2-yl)-4-methoxy-1H-indole-2-carboxamide; (3aR,6aS)-N-(4-hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)-2-(9-hydroxyl-9H- Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (3aS,6aR)-N-(4-hydroxyl-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)-2-(9-hydroxyl-9H- Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(4-methoxy-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; 9-Hydroxy-N-(1-((4-hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)amino)-4,4- Dimethyl-1-oxopentan-2-yl)-9H-oxo-9-formamide; 9-Hydroxy-N-((S)-1-(((S)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane- 2-yl)amino)-4,4-dimethyl-1-oxopentan-2-yl)-9H-stilbene-9-carboxamide; 9-Hydroxy-N-((S)-1-(((S)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane- 2-yl)amino)-4,4-dimethyl-1-oxopentan-2-yl)-9H-stilbene-9-carboxamide; 9-Hydroxy-N-((S)-1-(((R)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane- 2-yl)amino)-4,4-dimethyl-1-oxopentan-2-yl)-9H-stilbene-9-carboxamide; 9-Hydroxy-N-((S)-1-(((R)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane- 2-yl)amino)-4,4-dimethyl-1-oxopentan-2-yl)-9H-stilbene-9-carboxamide; 9-Hydroxy-N-((R)-1-(((S)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane- 2-yl)amino)-4,4-dimethyl-1-oxopentan-2-yl)-9H-stilbene-9-carboxamide; 9-Hydroxy-N-((R)-1-(((S)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane- 2-yl)amino)-4,4-dimethyl-1-oxopentan-2-yl)-9H-stilbene-9-carboxamide; 9-Hydroxy-N-((R)-1-(((R)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane- 2-yl)amino)-4,4-dimethyl-1-oxopentan-2-yl)-9H-stilbene-9-carboxamide; 9-Hydroxy-N-((R)-1-(((R)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane- 2-yl)amino)-4,4-dimethyl-1-oxopentan-2-yl)-9H-stilbene-9-carboxamide; N-(3-cyclohexyl-1-((4-hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)amino)-1-oxo Propan-2-yl)-9-(2,2,2-trifluoroacetamido)-9H-stilbene-9-carboxamide; N-((S)-3-cyclohexyl-1-(((S)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-1-oxopropan-2-yl)-9-(2,2,2-trifluoroacetamido)-9H-oxo-9-formamide; N-((S)-3-cyclohexyl-1-(((S)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-1-oxopropan-2-yl)-9-(2,2,2-trifluoroacetamido)-9H-oxo-9-formamide; N-((S)-3-cyclohexyl-1-(((R)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-1-oxopropan-2-yl)-9-(2,2,2-trifluoroacetamido)-9H-oxo-9-formamide; N-((S)-3-cyclohexyl-1-(((R)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-1-oxopropan-2-yl)-9-(2,2,2-trifluoroacetamido)-9H-oxo-9-formamide; N-((R)-3-cyclohexyl-1-(((S)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-1-oxopropan-2-yl)-9-(2,2,2-trifluoroacetamido)-9H-oxo-9-formamide; N-((R)-3-cyclohexyl-1-(((S)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-1-oxopropan-2-yl)-9-(2,2,2-trifluoroacetamido)-9H-oxo-9-formamide; N-((R)-3-cyclohexyl-1-(((R)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-1-oxopropan-2-yl)-9-(2,2,2-trifluoroacetamido)-9H-oxo-9-formamide; N-((R)-3-cyclohexyl-1-(((R)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane -2-yl)amino)-1-oxopropan-2-yl)-9-(2,2,2-trifluoroacetamido)-9H-oxo-9-formamide; N-(4-Hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)-2-(9-hydroxy-9H-oxo-9-carbonyl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (S)-N-((S)-4-hydroxyl-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 9-Hydroxy-9H-Oxane-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (S)-N-((S)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 9-Hydroxy-9H-Oxane-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (S)-N-((R)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 9-Hydroxy-9H-Oxane-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (S)-N-((R)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 9-Hydroxy-9H-Oxane-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-N-((S)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 9-Hydroxy-9H-Oxane-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-N-((S)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 9-Hydroxy-9H-Oxane-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-N-((R)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 9-Hydroxy-9H-Oxane-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-N-((R)-4-hydroxyl-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 9-Hydroxy-9H-Oxane-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; N-(1-((4-hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)amino)-4-methyl-1-oxo Pentane-2-yl)-4-methoxy-1-propyl-1H-indole-2-carboxamide; N-((S)-1-(((S)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) Amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1-propyl-1H-indole-2-carboxamide; N-((S)-1-(((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl) Amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1-propyl-1H-indole-2-carboxamide; N-((S)-1-(((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) Amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1-propyl-1H-indole-2-carboxamide; N-((S)-1-(((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) Amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1-propyl-1H-indole-2-carboxamide; N-((R)-1-(((S)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) Amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1-propyl-1H-indole-2-carboxamide; N-((R)-1-(((S)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) Amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1-propyl-1H-indole-2-carboxamide; N-((R)-1-(((R)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) Amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1-propyl-1H-indole-2-carboxamide; N-((R)-1-(((R)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) Amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1-propyl-1H-indole-2-carboxamide; (3aR,6aS)-N-(4-Hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)-2-(1H-indole-2 -carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (3aS,6aR)-N-(4-Hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)-2-(1H-indole-2 -carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-(1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-(1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-(1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-(1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-(1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-(1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-(1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; N-(1-((4-hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)amino)-4-methyl-1-oxo Pentan-2-yl)-4-methoxy-1-(2-methylallyl)-1H-indole-2-carboxamide; N-((S)-1-(((S)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) Amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1-(2-methylallyl)-1H-indole-2-carboxamide; N-((S)-1-(((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl) Amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1-(2-methylallyl)-1H-indole-2-carboxamide; N-((S)-1-(((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) Amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1-(2-methylallyl)-1H-indole-2-carboxamide; N-((S)-1-(((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) Amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1-(2-methylallyl)-1H-indole-2-carboxamide; N-((R)-1-(((S)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) Amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1-(2-methylallyl)-1H-indole-2-carboxamide; N-((R)-1-(((S)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) Amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1-(2-methylallyl)-1H-indole-2-carboxamide; N-((R)-1-(((R)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) Amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1-(2-methylallyl)-1H-indole-2-carboxamide; N-((R)-1-(((R)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) Amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1-(2-methylallyl)-1H-indole-2-carboxamide; N -(1-cyano-2-(2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-(9-hydroxy-9H-fennel-9-carbonyl)-2 - azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; 2-(2-(3-Chlorophenyl)-2-hydroxyacetyl) -N- (1-cyano-2-(2-oxopyrrolidin-3-yl)ethyl)-5,5 - Difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S )-2-(( S )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( S )-1-cyano-2- (( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S )-2-(( S )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( S )-1-cyano-2- (( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R )-2-(( S )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( S )-1-cyano-2- (( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R )-2-(( S )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( S )-1-cyano-2- (( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S )-2-(( R )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( S )-1-cyano-2- (( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S )-2-(( R )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( S )-1-cyano-2- (( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R )-2-(( R )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( S )-1-cyano-2- (( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R )-2-(( R )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( S )-1-cyano-2- (( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S )-2-(( S )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( R )-1-cyano-2- (( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S )-2-(( S )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( R )-1-cyano-2- (( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R )-2-(( S )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( R )-1-cyano-2- (( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R )-2-(( S )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( R )-1-cyano-2- (( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S )-2-(( R )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( R )-1-cyano-2- (( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S )-2-(( R )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( R )-1-cyano-2- (( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R )-2-(( R )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( R )-1-cyano-2- (( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R )-2-(( R )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( R )-1-cyano-2- (( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S )-2-(( S )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( S )-1-cyano-2- (( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide; (1 S ,3 R ,4 S )-2-(( S )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( S )-1-cyano-2- (( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide; (1 R ,3 S ,4 R )-2-(( S )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( S )-1-cyano-2- (( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide; (1 R ,3 R ,4 R )-2-(( S )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( S )-1-cyano-2- (( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide; (1 S ,3 S ,4 S )-2-(( R )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( S )-1-cyano-2- (( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide; (1 S ,3 R ,4 S )-2-(( R )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( S )-1-cyano-2- (( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide; (1 R ,3 S ,4 R )-2-(( R )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( S )-1-cyano-2- (( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide; (1 R ,3 R ,4 R )-2-(( R )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( S )-1-cyano-2- (( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide; (1 S ,3 S ,4 S )-2-(( S )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( R )-1-cyano-2- (( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide; (1 S ,3 R ,4 S )-2-(( S )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( R )-1-cyano-2- (( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide; (1 R ,3 S ,4 R )-2-(( S )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( R )-1-cyano-2- (( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide; (1 R ,3 R ,4 R )-2-(( S )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( R )-1-cyano-2- (( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide; (1 S ,3 S ,4 S )-2-(( R )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( R )-1-cyano-2- (( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide; (1 S ,3 R ,4 S )-2-(( R )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( R )-1-cyano-2- (( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide; (1 R ,3 S ,4 R )-2-(( R )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( R )-1-cyano-2- (( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide; (1 R ,3 R ,4 R )-2-(( R )-2-(3-chlorophenyl)-2-hydroxyacetyl) -N -(( R )-1-cyano-2- (( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide; N -[1-cyano-2-[2-oxopyrrolidin-3-yl]ethyl]-2-[2-(3,5-dichlorophenyl)-2,2-difluoro-ethyl Acyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ 2-(3,5-Dichlorophenyl)-2,2-difluoro-acetyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide ; (1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ 2-(3,5-Dichlorophenyl)-2,2-difluoro-acetyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide ; (1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ 2-(3,5-Dichlorophenyl)-2,2-difluoro-acetyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide ; (1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ 2-(3,5-Dichlorophenyl)-2,2-difluoro-acetyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide ; (1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ 2-(3,5-Dichlorophenyl)-2,2-difluoro-acetyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide ; (1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ 2-(3,5-Dichlorophenyl)-2,2-difluoro-acetyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide ; (1 R ,3 S ,4 R )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ 2-(3,5-Dichlorophenyl)-2,2-difluoro-acetyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide ; (1 R ,3 R ,4 R )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ 2-(3,5-Dichlorophenyl)-2,2-difluoro-acetyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide ; (1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ 2-(3,5-Dichlorophenyl)-2,2-difluoro-acetyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide ; (1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ 2-(3,5-Dichlorophenyl)-2,2-difluoro-acetyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide ; (1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ 2-(3,5-Dichlorophenyl)-2,2-difluoro-acetyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide ; (1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ 2-(3,5-Dichlorophenyl)-2,2-difluoro-acetyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide ; (1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ 2-(3,5-Dichlorophenyl)-2,2-difluoro-acetyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide ; (1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ 2-(3,5-Dichlorophenyl)-2,2-difluoro-acetyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide ; (1 R ,3 S ,4 R )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ 2-(3,5-Dichlorophenyl)-2,2-difluoro-acetyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide ; (1 R ,3 R ,4 R )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ 2-(3,5-Dichlorophenyl)-2,2-difluoro-acetyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide ; N -(1-cyano-2-(2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-(4-methoxy-1H-indole-2-carbonyl )-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; N -(1-cyano-2-(2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-(2-methyl-1H-indole-7-carbonyl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(2-methyl-1H-indole-7-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(2-methyl-1H-indole-7-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(2-methyl-1H-indole-7-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(2-methyl-1H-indole-7-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(2-methyl-1H-indole-7-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(2-methyl-1H-indole-7-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(2-methyl-1H-indole-7-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(2-methyl-1H-indole-7-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(2-methyl-1H-indole-7-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(2-methyl-1H-indole-7-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(2-methyl-1H-indole-7-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(2-methyl-1H-indole-7-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(2-methyl-1H-indole-7-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(2-methyl-1H-indole-7-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(2-methyl-1H-indole-7-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(2-methyl-1H-indole-7-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; N -(1-cyano-2-(oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-(2-hydroxy-2-phenylacryl)-2-aza Bicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( S )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( S )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( S )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( S )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( S )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( S )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( S )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( S )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( S )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( S )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( S )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( S )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( S )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( S )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( S )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( S )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( R )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( R )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( R )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( R )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( R )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( R )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( R )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R ) -N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( R )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( R )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( R )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( R )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R ) -N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( R )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( R )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( R )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( R )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R ) -N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-di Fluoro-2-(( R )-2-hydroxy-2-phenylacryl)-2-azabicyclo[2.2.2]octane-3-carboxamide; N- (1-cyano-2-(2-oxopyrrolidin-3-yl)ethyl)-2-(4-(difluoromethyl)-1H-indole-2-carbonyl)-5, 5-Difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S )- N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R ) -N -(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S )- N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S )- N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R )- N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R )- N -(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S )- N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S )- N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R )- N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R )- N -(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S )- N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S )- N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R )- N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R )- N -(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; N-(1-cyano-2-(2-oxopyrrolidin-3-yl)ethyl)-2-(4-(difluoromethyl)-6-fluoro-1H-indole-2-carbonyl )-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S )-N-(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S )-N-(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R )-N-(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R )-N-(( S )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S )-N-(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S )-N-(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R )-N-(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R )-N-(( R )-1-cyano-2-(( S )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S )-N-(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S )-N-(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R )-N-(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R )-N-(( S )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S )-N-(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S )-N-(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R )-N-(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R )-N-(( R )-1-cyano-2-(( R )-2-oxopyrrolidin-3-yl)ethyl)-2-(4- (Difluoromethyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; N -[1-cyano-2-[2-oxopyrrolidin-3-yl]ethyl]-2-[3-cyclobutyl-2-[(2,2,2-trifluoroacetyl )amino] propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 R ,3 S ,4 R )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 R ,3 R ,4 R )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 R ,3 S ,4 R )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 R ,3 R ,4 R )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3S)-2-oxopyrrolidin-3-yl]ethyl]-2-[( 2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2.2 ]octane-3-formamide; (1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 R ,3 S ,4 R )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 R ,3 R ,4 R )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 R ,3 S ,4 R )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 R ,3 R ,4 R )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxopyrrolidin-3-yl]ethyl]-2-[ (2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; 2-(7-Chloro-4-fluoro-1 H -indole-2-carbonyl) -N- [1-cyano-2-[2-oxo-3-piperidinyl]ethyl]-5 ,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamide; (1 S ,3 S ,4 S )-2-(7-chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 S )-1-cyano-2-[( 3S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide; (1 S ,3 R ,4 S )-2-(7-Chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 S )-1-cyano-2-[( 3S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide; (1 R ,3 S ,4 R )-2-(7-chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 S )-1-cyano-2-[( 3S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide; (1 R ,3 R ,4 R )-2-(7-chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 S )-1-cyano-2-[( 3S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide; (1 S ,3 S ,4 S )-2-(7-Chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 R )-1-cyano-2-[( 3S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide; (1 S ,3 R ,4 S )-2-(7-Chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 R )-1-cyano-2-[( 3S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide; (1 R ,3 S ,4 R )-2-(7-chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 R )-1-cyano-2-[( 3S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide; (1 R ,3 R ,4 R )-2-(7-chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 R )-1-cyano-2-[( 3S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide; (1 S ,3 S ,4 S )-2-(7-chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 S )-1-cyano-2-[( 3 R )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide; (1 S ,3 R ,4 S )-2-(7-Chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 S )-1-cyano-2-[( 3 R )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide; (1 R ,3 S ,4 R )-2-(7-chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 S )-1-cyano-2-[( 3 R )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide; (1 R ,3 R ,4 R )-2-(7-chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 S )-1-cyano-2-[( 3 R )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide; (1 S ,3 S ,4 S )-2-(7-Chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 R )-1-cyano-2-[( 3 R )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide; (1 S ,3 R ,4 S )-2-(7-Chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 R )-1-cyano-2-[( 3 R )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide; (1 R ,3 S ,4 R )-2-(7-chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 R )-1-cyano-2-[( 3 R )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide; (1 R ,3 R ,4 R )-2-(7-chloro-4-fluoro-1 H -indole-2-carbonyl) -N -[(1 R )-1-cyano-2-[( 3 R )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide; N -(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-(9-hydroxy-9H-fennel-9-carbonyl)-2 - azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S ) -N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S ) -N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R ) -N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R ) -N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S ) -N -(( R )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S ) -N -(( R )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R ) -N -(( R )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R ) -N -(( R )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S ) -N -(( S )-1-cyano-2-(( R )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S ) -N -(( S )-1-cyano-2-(( R )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R ) -N -(( S )-1-cyano-2-(( R )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R ) -N -(( S )-1-cyano-2-(( R )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S ) -N -(( R )-1-cyano-2-(( R )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S ) -N -(( R )-1-cyano-2-(( R )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R ) -N -(( R )-1-cyano-2-(( R )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R ) -N -(( R )-1-cyano-2-(( R )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(9-hydroxy-9H-oxa-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; N -(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-(4-methoxy-1H-indole-2-carbonyl )-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S ) -N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S ) -N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R ) -N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R ) -N -(( S )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S ) -N -(( R )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S ) -N -(( R )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R ) -N -(( R )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R ) -N -(( R )-1-cyano-2-(( S )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S ) -N -(( S )-1-cyano-2-(( R )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S ) -N -(( S )-1-cyano-2-(( R )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R ) -N -(( S )-1-cyano-2-(( R )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R ) -N -(( S )-1-cyano-2-(( R )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S ) -N -(( R )-1-cyano-2-(( R )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S ) -N -(( R )-1-cyano-2-(( R )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R ) -N -(( R )-1-cyano-2-(( R )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R ) -N -(( R )-1-cyano-2-(( R )-2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; N- [1-cyano-2-[2-oxo-3-piperidinyl]ethyl]-2-(4,7-difluoro-1 H -indole-2-carbonyl)-5, 5-Difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- (4,7-Difluoro- 1H -indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- (4,7-Difluoro- 1H -indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- (4,7-Difluoro- 1H -indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- (4,7-Difluoro- 1H -indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- (4,7-Difluoro- 1H -indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- (4,7-Difluoro- 1H -indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- (4,7-Difluoro- 1H -indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- (4,7-Difluoro- 1H -indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- (4,7-Difluoro- 1H -indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- (4,7-Difluoro- 1H -indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- (4,7-Difluoro- 1H -indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- (4,7-Difluoro- 1H -indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- (4,7-Difluoro- 1H -indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- (4,7-Difluoro- 1H -indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- (4,7-Difluoro- 1H -indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- (4,7-Difluoro- 1H -indole-2-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; N- [1-cyano-2-[2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-(4,6,7-trifluoro-1 H -ind Indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-(4,6,7-trifluoro-1 H -indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-(4,6,7-trifluoro-1 H -indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-(4,6,7-trifluoro-1 H -indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-(4,6,7-trifluoro-1 H -indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S ) -N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-(4,6,7-trifluoro-1 H -indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S ) -N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-(4,6,7-trifluoro-1 H -indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R ) -N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-(4,6,7-trifluoro-1 H -indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R ) -N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-(4,6,7-trifluoro-1 H -indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S ) -N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-(4,6,7-trifluoro-1 H -indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S ) -N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-(4,6,7-trifluoro-1 H -indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R ) -N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-(4,6,7-trifluoro-1 H -indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R ) -N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-(4,6,7-trifluoro-1 H -indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S ) -N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-(4,6,7-trifluoro-1 H -indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S ) -N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-(4,6,7-trifluoro-1 H -indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R ) -N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-(4,6,7-trifluoro-1 H -indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R ) -N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-(4,6,7-trifluoro-1 H -indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; 2-(3-Chloro- 4H -thieno[3,2-b]pyrrole-5-carbonyl) -N- [1-cyano-2-[2-oxo-3-piperidinyl]ethyl Base]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S )-2-(3-chloro-4 H -thieno[3,2-b]pyrrole-5-carbonyl) -N -[(1 S )-1-cyano- 2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S )-2-(3-Chloro-4 H -thieno[3,2-b]pyrrole-5-carbonyl) -N -[(1 S )-1-cyano- 2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R )-2-(3-chloro-4 H -thieno[3,2-b]pyrrole-5-carbonyl) -N -[(1 S )-1-cyano- 2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R )-2-(3-chloro-4 H -thieno[3,2-b]pyrrole-5-carbonyl) -N -[(1 S )-1-cyano- 2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S )-2-(3-Chloro-4 H -thieno[3,2-b]pyrrole-5-carbonyl) -N -[(1 R )-1-cyano- 2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S )-2-(3-Chloro-4 H -thieno[3,2-b]pyrrole-5-carbonyl) -N -[(1 R )-1-cyano- 2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R )-2-(3-chloro-4 H -thieno[3,2-b]pyrrole-5-carbonyl) -N -[(1 R )-1-cyano- 2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R )-2-(3-chloro-4 H -thieno[3,2-b]pyrrole-5-carbonyl) -N -[(1 R )-1-cyano- 2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S )-2-(3-chloro-4 H -thieno[3,2-b]pyrrole-5-carbonyl) -N -[(1 S )-1-cyano- 2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S )-2-(3-Chloro-4 H -thieno[3,2-b]pyrrole-5-carbonyl) -N -[(1 S )-1-cyano- 2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R )-2-(3-chloro-4 H -thieno[3,2-b]pyrrole-5-carbonyl) -N -[(1 S )-1-cyano- 2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R )-2-(3-chloro-4 H -thieno[3,2-b]pyrrole-5-carbonyl) -N -[(1 S )-1-cyano- 2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S )-2-(3-Chloro-4 H -thieno[3,2-b]pyrrole-5-carbonyl) -N -[(1 R )-1-cyano- 2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S )-2-(3-Chloro-4 H -thieno[3,2-b]pyrrole-5-carbonyl) -N -[(1 R )-1-cyano- 2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R )-2-(3-chloro-4 H -thieno[3,2-b]pyrrole-5-carbonyl) -N -[(1 R )-1-cyano- 2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R )-2-(3-chloro-4 H -thieno[3,2-b]pyrrole-5-carbonyl) -N -[(1 R )-1-cyano- 2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; 2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N- (1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-5,5- Difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S )-2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N -(( S )-1-cyano-2-((S)- 2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S )-2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N -(( S )-1-cyano-2-((S)- 2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R )-2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N -(( S )-1-cyano-2-((S)- 2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R )-2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N -(( S )-1-cyano-2-((S)- 2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S )-2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N -(( R )-1-cyano-2-((S)- 2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S )-2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N -(( R )-1-cyano-2-((S)- 2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R )-2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N -(( R )-1-cyano-2-((S)- 2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R )-2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N -(( R )-1-cyano-2-((S)- 2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S )-2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N -(( S )-1-cyano-2-((R)- 2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S )-2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N -(( S )-1-cyano-2-((R)- 2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R )-2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N -(( S )-1-cyano-2-((R)- 2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R )-2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N -(( S )-1-cyano-2-((R)- 2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S )-2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N -(( R )-1-cyano-2-((R)- 2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S )-2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N -(( R )-1-cyano-2-((R)- 2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R )-2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N -(( R )-1-cyano-2-((R)- 2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R )-2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N -(( R )-1-cyano-2-((R)- 2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; N -[1-cyano-2-[2-oxo-3-piperidinyl]ethyl]-2-[3-cyclobutyl-2-[(2,2,2-trifluoroacetyl Base) amino] propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 R ,3 S ,4 R )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 R ,3 R ,4 R )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 R ,3 S ,4 R )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 R ,3 R ,4 R )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 R ,3 S ,4 R )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 R ,3 R ,4 R )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 R ,3 S ,4 R )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 R ,3 R ,4 R )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclobutyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; N- [1-cyano-2-[2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-[4-methyl-2-[(2,2, 2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-[(2 S )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 S ,3 R ,4 S ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-[(2 S )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 R ,3 S ,4 R ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-[(2 S )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-[(2 S )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 S ,3 S ,4 S ) -N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-[(2 S )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 S ,3 R ,4 S ) -N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-[(2 S )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 R ,3 S ,4 R ) -N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-[(2 S )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 R ,3 R ,4 R ) -N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-[(2 S )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 S ,3 S ,4 S ) -N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-[(2 S )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 S ,3 R ,4 S ) -N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-[(2 S )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 R ,3 S ,4 R ) -N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-[(2 S )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 R ,3 R ,4 R ) -N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-[(2 S )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 S ,3 S ,4 S ) -N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-[(2 S )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 S ,3 R ,4 S ) -N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-[(2 S )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 R ,3 S ,4 R ) -N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-[(2 S )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 R ,3 R ,4 R ) -N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-difluoro-2-[(2 S )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-Difluoro-2-[(2 R )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 S ,3 R ,4 S ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-Difluoro-2-[(2 R )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 R ,3 S ,4 R ) -N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-Difluoro-2-[(2 R )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-Difluoro-2-[(2 R )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 S ,3 S ,4 S ) -N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-Difluoro-2-[(2 R )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 S ,3 R ,4 S ) -N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-Difluoro-2-[(2 R )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 R ,3 S ,4 R ) -N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-Difluoro-2-[(2 R )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 R ,3 R ,4 R ) -N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-5, 5-Difluoro-2-[(2 R )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 S ,3 S ,4 S ) -N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-Difluoro-2-[(2 R )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 S ,3 R ,4 S ) -N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-Difluoro-2-[(2 R )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 R ,3 S ,4 R ) -N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-Difluoro-2-[(2 R )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 R ,3 R ,4 R ) -N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-Difluoro-2-[(2 R )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 S ,3 S ,4 S ) -N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-Difluoro-2-[(2 R )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 S ,3 R ,4 S ) -N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-Difluoro-2-[(2 R )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 R ,3 S ,4 R ) -N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-Difluoro-2-[(2 R )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 R ,3 R ,4 R ) -N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-5, 5-Difluoro-2-[(2 R )-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentyl]-2-azabicyclo[2.2. 2] Octane-3-formamide; N -[1-cyano-2-[2-oxo-3-piperidinyl]ethyl]-2-[3-cyclopropyl-2-[(2,2,2-trifluoroacetyl Base) amino] propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 S )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; (1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2 R )-3-cyclopropyl-2-[(2,2,2-trifluoroacetyl)amino]propionyl]-5,5-difluoro-2-azabicyclo[2.2 .2] octane-3-carboxamide; N -[1-cyano-2-[2-oxo-3-piperidinyl]ethyl]-2-[3,3-dimethyl-2-[(2,2,2-trifluoro Acetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2S)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2S)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2S)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2S)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2S)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2S)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 R ,3 S ,4 R )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2S)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 R ,3 R ,4 R )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2S)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2S)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2S)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2S)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2S)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2S)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2S)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 R ,3 S ,4 R )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2S)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 R ,3 R ,4 R )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2S)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2R)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2R)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2R)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2R)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2R)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2R)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 R ,3 S ,4 R )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2R)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 R ,3 R ,4 R )- N -[(1 R )-1-cyano-2-[(3 S )-2-oxo-3-piperidinyl]ethyl]-2- [(2R)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2R)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2R)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2R)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2R)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2R)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2R)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 R ,3 S ,4 R )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2R)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; (1 R ,3 R ,4 R )- N -[(1 R )-1-cyano-2-[(3 R )-2-oxo-3-piperidinyl]ethyl]-2- [(2R)-3,3-Dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butyryl]-5,5-difluoro-2-azabicyclo[2.2. 2] Octane-3-formamide; N -[1-cyano-2-[2-oxo-3-piperidinyl]ethyl]-2-[2-(2,5-difluoroaniline)propionyl]-5,5- Difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3S)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 S )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3S)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 S )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3S)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 S )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3S)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 S )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3S)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 S )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3S)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 S )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R )- N -[(1 R )-1-cyano-2-[(3S)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 S )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R )- N -[(1 R )-1-cyano-2-[(3S)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 S )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3R)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 S )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3R)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 S )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3R)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 S )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3R)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 S )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3R)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 S )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S ) -N -[(1 R )-1-cyano-2-[(3R)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 S )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R ) -N -[(1 R )-1-cyano-2-[(3R)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 S )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R ) -N -[(1 R )-1-cyano-2-[(3R)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 S )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3S)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 R )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3S)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 R )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3S)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 R )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3S)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 R )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3S)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 R )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S )- N -[(1 R )-1-cyano-2-[(3S)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 R )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R )- N -[(1 R )-1-cyano-2-[(3S)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 R )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R )- N -[(1 R )-1-cyano-2-[(3S)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 R )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S )- N -[(1 S )-1-cyano-2-[(3R)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 R )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S )- N -[(1 S )-1-cyano-2-[(3R)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 R )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R )- N -[(1 S )-1-cyano-2-[(3R)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 R )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R )- N -[(1 S )-1-cyano-2-[(3R)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 R )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S )- N -[(1 R )-1-cyano-2-[(3R)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 R )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 R ,4 S ) -N -[(1 R )-1-cyano-2-[(3R)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 R )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 S ,4 R ) -N -[(1 R )-1-cyano-2-[(3R)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 R )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 R ,3 R ,4 R ) -N -[(1 R )-1-cyano-2-[(3R)-2-oxo-3-piperidinyl]ethyl]-2-[ (2 R )-2-(2,5-difluoroaniline)propionyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; 2-[2-(3-Chloro-2-methyl-aniline)propionyl]-N-[1-cyano-2-[2-oxo-3-piperidinyl]ethyl]-5 ,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamide; (1S,3S,4S)-2-[(2S)-2-(3-Chloro-2-methyl-aniline)propionyl]-N-[(1S)-1-cyano-2-[( 3S)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-[(2S)-2-(3-Chloro-2-methyl-aniline)propionyl]-N-[(1S)-1-cyano-2-[( 3S)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-[(2S)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1S)-1-cyano-2-[( 3S)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-[(2S)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1S)-1-cyano-2-[( 3S)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-[(2R)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1S)-1-cyano-2-[( 3S)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-[(2R)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1S)-1-cyano-2-[( 3S)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-[(2R)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1S)-1-cyano-2-[( 3S)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-[(2R)-2-(3-Chloro-2-methyl-aniline)propionyl]-N-[(1S)-1-cyano-2-[( 3S)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-[(2S)-2-(3-Chloro-2-methyl-aniline)propionyl]-N-[(1R)-1-cyano-2-[( 3S)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-[(2S)-2-(3-Chloro-2-methyl-aniline)propionyl]-N-[(1R)-1-cyano-2-[( 3S)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-[(2S)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1R)-1-cyano-2-[( 3S)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-[(2S)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1R)-1-cyano-2-[( 3S)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-[(2R)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1R)-1-cyano-2-[( 3S)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-[(2R)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1R)-1-cyano-2-[( 3S)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-[(2R)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1R)-1-cyano-2-[( 3S)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-[(2R)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1R)-1-cyano-2-[( 3S)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-[(2S)-2-(3-Chloro-2-methyl-aniline)propionyl]-N-[(1S)-1-cyano-2-[( 3R)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide; (1S,3R,4S)-2-[(2S)-2-(3-Chloro-2-methyl-aniline)propionyl]-N-[(1S)-1-cyano-2-[( 3R)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide; (1R,3S,4R)-2-[(2S)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1S)-1-cyano-2-[( 3R)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide; (1R,3R,4R)-2-[(2S)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1S)-1-cyano-2-[( 3R)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide; (1S,3S,4S)-2-[(2R)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1S)-1-cyano-2-[( 3R)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide; (1S,3R,4S)-2-[(2R)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1S)-1-cyano-2-[( 3R)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide; (1R,3S,4R)-2-[(2R)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1S)-1-cyano-2-[( 3R)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide; (1R,3R,4R)-2-[(2R)-2-(3-Chloro-2-methyl-aniline)propionyl]-N-[(1S)-1-cyano-2-[( 3R)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide; (1S,3S,4S)-2-[(2S)-2-(3-Chloro-2-methyl-aniline)propionyl]-N-[(1R)-1-cyano-2-[( 3R)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide; (1S,3R,4S)-2-[(2S)-2-(3-Chloro-2-methyl-aniline)propionyl]-N-[(1R)-1-cyano-2-[( 3R)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide; (1R,3S,4R)-2-[(2S)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1R)-1-cyano-2-[( 3R)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide; (1R,3R,4R)-2-[(2S)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1R)-1-cyano-2-[( 3R)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide; (1S,3S,4S)-2-[(2R)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1R)-1-cyano-2-[( 3R)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide; (1S,3R,4S)-2-[(2R)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1R)-1-cyano-2-[( 3R)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide; (1R,3S,4R)-2-[(2R)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1R)-1-cyano-2-[( 3R)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide; (1R,3R,4R)-2-[(2R)-2-(3-chloro-2-methyl-aniline)propionyl]-N-[(1R)-1-cyano-2-[( 3R)-2-oxo-3-piperidinyl]ethyl]-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamide; N-(4-hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)-2-(2-methyl-4H-thieno[3, 2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-formamide; (S)-N-((S)-4-hydroxyl-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 2-methyl-4H-thieno[3,2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (S)-N-((S)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 2-methyl-4H-thieno[3,2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (S)-N-((R)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 2-methyl-4H-thieno[3,2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (S)-N-((R)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 2-methyl-4H-thieno[3,2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-N-((S)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 2-methyl-4H-thieno[3,2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-N-((S)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 2-methyl-4H-thieno[3,2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-N-((R)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 2-methyl-4H-thieno[3,2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-N-((R)-4-hydroxyl-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 2-methyl-4H-thieno[3,2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; 2-(3-Chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-(4-hydroxy-3-oxo-1-(2-oxopyrrolidine-3- Base) butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (S)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-4-hydroxyl-3-oxo-1-(( S) -2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (S)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-4-hydroxyl-3-oxo-1-(( R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (S)-2-(3-Chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-4-hydroxyl-3-oxo-1-(( S) -2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (S)-2-(3-Chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-4-hydroxyl-3-oxo-1-(( R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-4-hydroxyl-3-oxo-1-(( S) -2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-4-hydroxyl-3-oxo-1-(( R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-4-hydroxyl-3-oxo-1-(( S) -2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-4-hydroxyl-3-oxo-1-(( R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide; N-(4-Hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)-2-(4-methoxy-1H-indole-2 -carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (S)-N-((S)-4-hydroxyl-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (S)-N-((S)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (S)-N-((R)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (S)-N-((R)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-N-((S)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-N-((S)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-N-((R)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-N-((R)-4-hydroxyl-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; N-(4-hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)-2-(3-methyl-4H-thieno[3, 2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-formamide; (S)-N-((S)-4-hydroxyl-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 3-methyl-4H-thieno[3,2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (S)-N-((S)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 3-methyl-4H-thieno[3,2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (S)-N-((R)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 3-methyl-4H-thieno[3,2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (S)-N-((R)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 3-methyl-4H-thieno[3,2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-N-((S)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 3-methyl-4H-thieno[3,2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-N-((S)-4-hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 3-methyl-4H-thieno[3,2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-N-((R)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 3-methyl-4H-thieno[3,2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-N-((R)-4-hydroxyl-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-( 3-methyl-4H-thieno[3,2-b]pyrrole-5-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; 2-(4,6-Difluoro-1H-indole-2-carbonyl)-N-(4-hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane- 2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (S)-2-(4,6-difluoro-1H-indole-2-carbonyl)-N-((S)-4-hydroxy-3-oxo-1-((S)-2- Oxypyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (S)-2-(4,6-difluoro-1H-indole-2-carbonyl)-N-((S)-4-hydroxy-3-oxo-1-((R)-2- Oxypyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (S)-2-(4,6-difluoro-1H-indole-2-carbonyl)-N-((R)-4-hydroxy-3-oxo-1-((S)-2- Oxypyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (S)-2-(4,6-difluoro-1H-indole-2-carbonyl)-N-((R)-4-hydroxy-3-oxo-1-((R)-2- Oxypyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-2-(4,6-difluoro-1H-indole-2-carbonyl)-N-((S)-4-hydroxy-3-oxo-1-((S)-2- Oxypyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-2-(4,6-difluoro-1H-indole-2-carbonyl)-N-((S)-4-hydroxy-3-oxo-1-((R)-2- Oxypyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-2-(4,6-difluoro-1H-indole-2-carbonyl)-N-((R)-4-hydroxy-3-oxo-1-((S)-2- Oxypyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-2-(4,6-difluoro-1H-indole-2-carbonyl)-N-((R)-4-hydroxy-3-oxo-1-((R)-2- Oxypyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide; 2-(9-fluoro-9H-fluorene-9-carbonyl)-N-(4-hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(9-fluoro-9H-fennel-9-carbonyl)-N-((S)-4-hydroxyl-3-oxo-1-((S)-2- Oxypyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(9-Fluoro-9H-fennel-9-carbonyl)-N-((S)-4-hydroxy-3-oxo-1-((R)-2- Oxypyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(9-Fluoro-9H-fennel-9-carbonyl)-N-((R)-4-hydroxyl-3-oxo-1-((S)-2- Oxypyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(9-Fluoro-9H-fennel-9-carbonyl)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2- Oxypyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-(9-Fluoro-9H-fennel-9-carbonyl)-N-((S)-4-hydroxy-3-oxo-1-((S)-2- Oxypyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-(9-Fluoro-9H-fennel-9-carbonyl)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2- Oxypyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-(9-Fluoro-9H-fennel-9-carbonyl)-N-((R)-4-hydroxyl-3-oxo-1-((S)-2- Oxypyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-(9-Fluoro-9H-fennel-9-carbonyl)-N-((R)-4-hydroxyl-3-oxo-1-((R)-2- Oxypyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(9-fluoro-9H-fennel-9-carbonyl)-N-((S)-4-hydroxyl-3-oxo-1-((S)-2- Oxypyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(9-Fluoro-9H-fennel-9-carbonyl)-N-((S)-4-hydroxy-3-oxo-1-((R)-2- Oxypyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(9-Fluoro-9H-fennel-9-carbonyl)-N-((R)-4-hydroxyl-3-oxo-1-((S)-2- Oxypyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(9-Fluoro-9H-fennel-9-carbonyl)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2- Oxypyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-(9-Fluoro-9H-fennel-9-carbonyl)-N-((S)-4-hydroxy-3-oxo-1-((S)-2- Oxypyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-(9-Fluoro-9H-fennel-9-carbonyl)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2- Oxypyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-(9-Fluoro-9H-fennel-9-carbonyl)-N-((R)-4-hydroxyl-3-oxo-1-((S)-2- Oxypyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-(9-Fluoro-9H-fennel-9-carbonyl)-N-((R)-4-hydroxyl-3-oxo-1-((R)-2- Oxypyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; 2-(9-Acetamido-9H-oxo-9-carbonyl)-N-(4-hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2 -yl) octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(9-Acetamido-9H-oxo-9-carbonyl)-N-((S)-4-hydroxy-3-oxo-1-((S) -2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(9-Acetamido-9H-oxo-9-carbonyl)-N-((S)-4-hydroxy-3-oxo-1-((R) -2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(9-Acetamido-9H-oxo-9-carbonyl)-N-((R)-4-hydroxy-3-oxo-1-((S) -2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(9-Acetamido-9H-oxo-9-carbonyl)-N-((R)-4-hydroxy-3-oxo-1-((R) -2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-(9-Acetamido-9H-oxo-9-carbonyl)-N-((S)-4-hydroxyl-3-oxo-1-((S) -2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-(9-Acetamido-9H-oxo-9-carbonyl)-N-((S)-4-hydroxy-3-oxo-1-((R) -2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-(9-Acetamido-9H-oxo-9-carbonyl)-N-((R)-4-hydroxy-3-oxo-1-((S) -2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-(9-Acetamido-9H-oxo-9-carbonyl)-N-((R)-4-hydroxy-3-oxo-1-((R) -2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-2-(9-Acetamido-9H-oxo-9-carbonyl)-N-((S)-4-hydroxy-3-oxo-1-((S) -2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-2-(9-Acetamido-9H-oxo-9-carbonyl)-N-((S)-4-hydroxy-3-oxo-1-((R) -2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-2-(9-Acetamido-9H-oxo-9-carbonyl)-N-((R)-4-hydroxy-3-oxo-1-((S) -2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-2-(9-Acetamido-9H-oxo-9-carbonyl)-N-((R)-4-hydroxy-3-oxo-1-((R) -2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-2-(9-Acetamido-9H-oxo-9-carbonyl)-N-((S)-4-hydroxyl-3-oxo-1-((S) -2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-2-(9-Acetamido-9H-oxo-9-carbonyl)-N-((S)-4-hydroxy-3-oxo-1-((R) -2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-2-(9-Acetamido-9H-oxo-9-carbonyl)-N-((R)-4-hydroxy-3-oxo-1-((S) -2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-2-(9-Acetamido-9H-oxo-9-carbonyl)-N-((R)-4-hydroxy-3-oxo-1-((R) -2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; N-(4-Hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl)-2-(5-oxo-2-phenylpyrrolidine -2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-(5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-((S)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((R)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((S)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((R)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-((S)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-((R)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((S)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((R)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((S)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((R)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((S)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-((R)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((S)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-((R)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-((S)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((R)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((S)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((R)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-((S)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-((R)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-((S)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-((R)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-((S)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-((R)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((S)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((R)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl) -2-((S)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((S)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((R)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((S)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((R)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((S)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((R)-4-Hydroxy-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl) -2-((R)-5-oxo-2-phenylpyrrolidinyl-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; 2-(2-Cyclopentyl-2-hydroxy-2-phenylacetyl)-N-(4-hydroxy-3-oxo-1-(2-oxopyrrolidin-3-yl)butane -2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (3S)-2-(2-Cyclopentyl-2-hydroxy-2-phenylacetyl)-N-((S)-4-hydroxy-3-oxo-1-((S)-2 -Oxopyrrolidin-3-yl)butan-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (S)-2-((S)-2-cyclopentyl-2-hydroxyl-2-phenylacetyl)-N-((S)-4-hydroxyl-3-oxo-1-(( S) -2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (S)-2-((S)-2-cyclopentyl-2-hydroxyl-2-phenylacetyl)-N-((S)-4-hydroxyl-3-oxo-1-(( R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (S)-2-((S)-2-cyclopentyl-2-hydroxyl-2-phenylacetyl)-N-((R)-4-hydroxyl-3-oxo-1-(( S) -2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (S)-2-((S)-2-cyclopentyl-2-hydroxyl-2-phenylacetyl)-N-((R)-4-hydroxyl-3-oxo-1-(( R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (S)-2-((R)-2-cyclopentyl-2-hydroxyl-2-phenylacetyl)-N-((S)-4-hydroxyl-3-oxo-1-(( S) -2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (S)-2-((R)-2-cyclopentyl-2-hydroxyl-2-phenylacetyl)-N-((S)-4-hydroxyl-3-oxo-1-(( R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (S)-2-((R)-2-cyclopentyl-2-hydroxyl-2-phenylacetyl)-N-((R)-4-hydroxyl-3-oxo-1-(( S) -2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (S)-2-((R)-2-cyclopentyl-2-hydroxyl-2-phenylacetyl)-N-((R)-4-hydroxyl-3-oxo-1-(( R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-2-((S)-2-cyclopentyl-2-hydroxyl-2-phenylacetyl)-N-((S)-4-hydroxyl-3-oxo-1-(( S) -2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-2-((S)-2-cyclopentyl-2-hydroxyl-2-phenylacetyl)-N-((S)-4-hydroxyl-3-oxo-1-(( R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-2-((S)-2-cyclopentyl-2-hydroxyl-2-phenylacetyl)-N-((R)-4-hydroxyl-3-oxo-1-(( S) -2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-2-((S)-2-cyclopentyl-2-hydroxyl-2-phenylacetyl)-N-((R)-4-hydroxyl-3-oxo-1-(( R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-2-((R)-2-cyclopentyl-2-hydroxy-2-phenylacetyl)-N-((S)-4-hydroxy-3-oxo-1-(( S) -2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-2-((R)-2-cyclopentyl-2-hydroxy-2-phenylacetyl)-N-((S)-4-hydroxy-3-oxo-1-(( R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-2-((R)-2-cyclopentyl-2-hydroxyl-2-phenylacetyl)-N-((R)-4-hydroxyl-3-oxo-1-(( S) -2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-2-((R)-2-cyclopentyl-2-hydroxyl-2-phenylacetyl)-N-((R)-4-hydroxyl-3-oxo-1-(( R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide; N-(1-cyano-2-(2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo [2.2.2] Octane-3-formamide; (S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy-1H-ind Indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (S)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy-1H-ind Indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (S)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2,-(4-methoxy-1H- Indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (S)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy-1H-ind Indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy-1H-ind Indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy-1H-ind Indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy-1H-ind Indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy-1H-ind Indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; 2-(3-Chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-(1-cyano-2-(2-oxopyrrolidin-3-yl)ethyl) -5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-(3-Chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-1-cyano-2-((S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-(3-Chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-1-cyano-2-((R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-1-cyano-2-((S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-(3-Chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-1-cyano-2-((R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-1-cyano-2-((S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-(3-Chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-1-cyano-2-((R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-1-cyano-2-((S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-1-cyano-2-((R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-(3-Chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-1-cyano-2-((S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-(3-Chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-1-cyano-2-((R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-1-cyano-2-((S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-1-cyano-2-((R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-1-cyano-2-((S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-1-cyano-2-((R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-1-cyano-2-((S )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-1-cyano-2-((R )-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,2S,5S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-3-(9-hydroxyl-9H -Treme-9-carbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide; N-(1-cyano-2-(2-oxopyrrolidin-3-yl)ethyl)-3-(9-hydroxy-9H-fenflure-9-carbonyl)-6,6-dimethyl- 3-Azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-3-(9-hydroxyl-9H -Treme-9-carbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-3-(9-hydroxyl-9H -Treme-9-carbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-3-(9-hydroxyl-9H -Treme-9-carbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-3-(9-hydroxyl-9H -Treme-9-carbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,2S,5R)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-3-(9-hydroxyl-9H -Treme-9-carbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,2S,5R)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-3-(9-hydroxyl-9H -Treme-9-carbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,2S,5R)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-3-(9-hydroxyl-9H -Treme-9-carbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,2S,5R)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-3-(9-hydroxyl-9H -Treme-9-carbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2R,5S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-3-(9-hydroxyl-9H -Treme-9-carbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2R,5S)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-3-(9-hydroxyl-9H -Treme-9-carbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2R,5S)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-3-(9-hydroxyl-9H -Treme-9-carbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2R,5S)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-3-(9-hydroxyl-9H -Treme-9-carbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,2R,5R)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-3-(9-hydroxyl-9H -Treme-9-carbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,2R,5R)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-3-(9-hydroxyl-9H -Treme-9-carbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,2R,5R)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-3-(9-hydroxyl-9H -Treme-9-carbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,2R,5R)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-3-(9-hydroxyl-9H -Treme-9-carbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide; N-(1-cyano-2-(2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2-((2,2,2-trifluoroacetyl)- Leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-D-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-L-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-D-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-L-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-D-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-L-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-D-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-L-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-D-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-L-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-D-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-L-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-D-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-L-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-D-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-L-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-D-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-L-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-D-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-L-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-D-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-L-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-D-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-L-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-D-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-L-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-D-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-L-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-D-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-L-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-D-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro-2 -((2,2,2-trifluoroacetyl)-L-leucyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; N-(1-cyano-2-(2-oxopyrrolidin-3-yl)ethyl)-2-(3-cyclobutyl-2-(2,2,2-trifluoroacetamido ) propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine; (1S,3S,4S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine; (1S,3S,4S)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine; (1S,3S,4S)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine; (1S,3S,4S)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine; (1S,3S,4S)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine; (1S,3S,4S)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine; (1S,3S,4S)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine; (1R,3S,4R)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine; (1R,3S,4R)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine; (1R,3S,4R)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine; (1R,3S,4R)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine; (1R,3S,4R)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine; (1R,3S,4R)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine; (1R,3S,4R)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine; (1R,3S,4R)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine; (1S,3R,4S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine; (1S,3R,4S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine; (1S,3R,4S)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine; (1S,3R,4S)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine; (1S,3R,4S)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine; (1S,3R,4S)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine; (1S,3R,4S)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine; (1S,3R,4S)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine; (1R,3R,4R)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine; (1R,3R,4R)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine; (1R,3R,4R)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine; (1R,3R,4R)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine; (1R,3R,4R)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine; (1R,3R,4R)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine; (1R,3R,4R)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine; (1R,3R,4R)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formyl amine; 2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N- (1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-5,5- Difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1 S ,3 S ,4 S )-2-(2-Chloro-9-hydroxy-9H-fennel-9-carbonyl) -N -(( S )-1-cyano-2-((S)- 2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((S)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((S)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((S)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((S)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((R)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((R)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((R)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((R)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((S)-2-chloro-9-hydroxyl-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((S)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((S)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((S)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((R)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((R)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((R)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((R)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((S)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((S)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((S)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((S)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((R)-2-Chloro-9-hydroxyl-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((R)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((R)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((R)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((S)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((S)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((S)-2-chloro-9-hydroxyl-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((S)-2-chloro-9-hydroxyl-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((R)-2-chloro-9-hydroxyl-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((R)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((R)-2-chloro-9-hydroxyl-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((R)-2-Chloro-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-2-(4-methoxy-1H-indole-2-carbonyl)-2-azabicyclo [2.2.2] Octane-3-formamide; (S)-N-((S)-1-fluoro-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-methoxy-1H-ind Indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-methoxy-1H-ind Indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-methoxy-1H-ind Indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-methoxy-1H-ind Indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-methoxy-1H-ind Indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-methoxy-1H-ind Indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-methoxy-1H-ind Indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-methoxy-1H-ind Indole-2-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((3-Chlorophenyl)-D-leucyl)-N-((S)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((3-Chlorophenyl)-D-leucyl)-N-((S)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((3-Chlorophenyl)-D-leucyl)-N-((S)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((3-Chlorophenyl)-D-leucyl)-N-((R)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((3-Chlorophenyl)-D-leucyl)-N-((R)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((3-Chlorophenyl)-L-leucyl)-N-((S)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((3-Chlorophenyl)-L-leucyl)-N-((S)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((3-Chlorophenyl)-L-leucyl)-N-((R)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((3-Chlorophenyl)-L-leucyl)-N-((R)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((3-Chlorophenyl)-D-leucyl)-N-((S)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((3-Chlorophenyl)-D-leucyl)-N-((S)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((3-Chlorophenyl)-D-leucyl)-N-((R)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((3-Chlorophenyl)-D-leucyl)-N-((R)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((3-Chlorophenyl)-L-leucyl)-N-((S)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((3-Chlorophenyl)-L-leucyl)-N-((S)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((3-Chlorophenyl)-L-leucyl)-N-((R)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((3-Chlorophenyl)-L-leucyl)-N-((R)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((3-Chlorophenyl)-D-leucyl)-N-((S)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((3-Chlorophenyl)-D-leucyl)-N-((S)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((3-Chlorophenyl)-D-leucyl)-N-((R)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((3-Chlorophenyl)-D-leucyl)-N-((R)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((3-Chlorophenyl)-L-leucyl)-N-((S)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((3-Chlorophenyl)-L-leucyl)-N-((S)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((3-Chlorophenyl)-L-leucyl)-N-((R)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((3-Chlorophenyl)-L-leucyl)-N-((R)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((3-Chlorophenyl)-D-leucyl)-N-((S)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((3-Chlorophenyl)-D-leucyl)-N-((S)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((3-Chlorophenyl)-D-leucyl)-N-((R)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((3-Chlorophenyl)-D-leucyl)-N-((R)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((3-Chlorophenyl)-L-leucyl)-N-((S)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((3-Chlorophenyl)-L-leucyl)-N-((S)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((3-Chlorophenyl)-L-leucyl)-N-((R)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((3-Chlorophenyl)-L-leucyl)-N-((R)-1-cyano-2-((R)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; 2-(2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl Base)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((S)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((S)-1-cyano -2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((S)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((S)-1-cyano -2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((S)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((R)-1-cyano -2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((S)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((R)-1-cyano -2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((R)-2-((3-Chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((S)-1-cyano -2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((R)-2-((3-Chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((S)-1-cyano -2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((R)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((R)-1-cyano -2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((R)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((R)-1-cyano -2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((S)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((S)-1-cyano -2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((S)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((S)-1-cyano -2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((S)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((R)-1-cyano -2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((S)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((R)-1-cyano -2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((R)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((S)-1-cyano -2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((R)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((S)-1-cyano -2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((R)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((R)-1-cyano -2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((R)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((R)-1-cyano -2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((S)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((S)-1-cyano -2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((S)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((S)-1-cyano -2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((S)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((R)-1-cyano -2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((S)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((R)-1-cyano -2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((R)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((S)-1-cyano -2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((R)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((S)-1-cyano -2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((R)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((R)-1-cyano -2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((R)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((R)-1-cyano -2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((S)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((S)-1-cyano -2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((S)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((S)-1-cyano -2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((S)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((R)-1-cyano -2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((S)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((R)-1-cyano -2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((R)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((S)-1-cyano -2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((R)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((S)-1-cyano -2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((R)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((R)-1-cyano -2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((R)-2-((3-chlorophenyl)amino)-3-cyclopropylpropionyl)-N-((R)-1-cyano -2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-2-(3-cyclopropyl-2-((5-methylpyridin-3-yl)amine Base) propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1S,3S,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1S,3S,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1S,3S,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1S,3S,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1S,3S,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1S,3S,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1S,3S,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1R,3S,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1R,3S,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1R,3S,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1R,3S,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1R,3S,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1R,3S,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1R,3S,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1R,3S,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1S,3R,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1S,3R,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1S,3R,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1S,3R,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1S,3R,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1S,3R,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1S,3R,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1S,3R,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1R,3R,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1R,3R,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1R,3R,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1R,3R,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1R,3R,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1R,3R,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1R,3R,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1R,3R,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl)-propanamidoyl)-5,5-di Fluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-D-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-L-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-D-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-L-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-D-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-L-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-D-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-L-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-D-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-L-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-D-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-L-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-D-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-L-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-D-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-L-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-D-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-L-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-D-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-L-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-D-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-L-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-D-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-L-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-D-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-L-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-D-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-L-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-D-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-N-((R)-1-cyano-2-((S)-2-oxopiper-3-yl)ethyl)-2-((2,5- Difluorophenyl)-L-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-D-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5- Difluorophenyl)-L-propanylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; 2-((5-Chloropyridin-3-yl)-propanylamino)-N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-5,5-di Fluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((5-Chloropyridin-3-yl)-D-propanylamino)-N-((S)-1-cyano-2-((S)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((5-Chloropyridin-3-yl)-D-propanylamino)-N-((S)-1-cyano-2-((R)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((5-Chloropyridin-3-yl)-D-propanylamino)-N-((R)-1-cyano-2-((S)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((5-Chloropyridin-3-yl)-D-propanylamino)-N-((R)-1-cyano-2-((R)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((5-Chloropyridin-3-yl)-L-propanylamino)-N-((S)-1-cyano-2-((S)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((5-Chloropyridin-3-yl)-L-propanylamino)-N-((S)-1-cyano-2-((R)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((5-Chloropyridin-3-yl)-L-propanylamino)-N-((R)-1-cyano-2-((S)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((5-Chloropyridin-3-yl)-L-propanylamino)-N-((R)-1-cyano-2-((R)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((5-Chloropyridin-3-yl)-D-propanylamino)-N-((S)-1-cyano-2-((S)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((5-Chloropyridin-3-yl)-D-propanylamino)-N-((S)-1-cyano-2-((R)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((5-Chloropyridin-3-yl)-D-propanylamino)-N-((R)-1-cyano-2-((S)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((5-Chloropyridin-3-yl)-D-propanylamino)-N-((R)-1-cyano-2-((R)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((5-Chloropyridin-3-yl)-L-propanylamino)-N-((S)-1-cyano-2-((S)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((5-Chloropyridin-3-yl)-L-propanylamino)-N-((S)-1-cyano-2-((R)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((5-Chloropyridin-3-yl)-L-propanylamino)-N-((R)-1-cyano-2-((S)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((5-Chloropyridin-3-yl)-L-propanylamino)-N-((R)-1-cyano-2-((R)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((5-Chloropyridin-3-yl)-D-propanylamino)-N-((S)-1-cyano-2-((S)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((5-Chloropyridin-3-yl)-D-propanylamino)-N-((S)-1-cyano-2-((R)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((5-Chloropyridin-3-yl)-D-propanylamino)-N-((R)-1-cyano-2-((S)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((5-Chloropyridin-3-yl)-D-propanylamino)-N-((R)-1-cyano-2-((R)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((5-Chloropyridin-3-yl)-L-propanylamino)-N-((S)-1-cyano-2-((S)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((5-Chloropyridin-3-yl)-L-propanylamino)-N-((S)-1-cyano-2-((R)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((5-Chloropyridin-3-yl)-L-propanylamino)-N-((R)-1-cyano-2-((S)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((5-Chloropyridin-3-yl)-L-propanylamino)-N-((R)-1-cyano-2-((R)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((5-Chloropyridin-3-yl)-D-propanylamino)-N-((S)-1-cyano-2-((S)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((5-Chloropyridin-3-yl)-D-propanylamino)-N-((S)-1-cyano-2-((R)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((5-Chloropyridin-3-yl)-D-propanylamino)-N-((R)-1-cyano-2-((S)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((5-Chloropyridin-3-yl)-D-propanylamino)-N-((R)-1-cyano-2-((R)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((5-Chloropyridin-3-yl)-L-propanylamino)-N-((S)-1-cyano-2-((S)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((5-Chloropyridin-3-yl)-L-propanylamino)-N-((S)-1-cyano-2-((R)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((5-Chloropyridin-3-yl)-L-propanylamino)-N-((R)-1-cyano-2-((S)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((5-Chloropyridin-3-yl)-L-propanylamino)-N-((R)-1-cyano-2-((R)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; 2-((3-Chlorophenyl)-propanylamino)-N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 - azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((3-Chlorophenyl)-D-propanylamino)-N-((S)-1-cyano-2-((S)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((3-Chlorophenyl)-D-propanylamino)-N-((S)-1-cyano-2-((R)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((3-Chlorophenyl)-D-propanylamino)-N-((R)-1-cyano-2-((S)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((3-Chlorophenyl)-D-propanylamino)-N-((R)-1-cyano-2-((R)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((3-Chlorophenyl)-L-propanylamino)-N-((S)-1-cyano-2-((S)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((3-Chlorophenyl)-L-propanylamino)-N-((S)-1-cyano-2-((R)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((3-Chlorophenyl)-L-propanylamino)-N-((R)-1-cyano-2-((S)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((3-Chlorophenyl)-L-propanylamino)-N-((R)-1-cyano-2-((R)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((3-Chlorophenyl)-D-propanylamino)-N-((S)-1-cyano-2-((S)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((3-Chlorophenyl)-D-propanylamino)-N-((S)-1-cyano-2-((R)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((3-Chlorophenyl)-D-propanylamino)-N-((R)-1-cyano-2-((S)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((3-Chlorophenyl)-D-propanylamino)-N-((R)-1-cyano-2-((R)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((3-Chlorophenyl)-L-propanylamino)-N-((S)-1-cyano-2-((S)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((3-Chlorophenyl)-L-propanylamino)-N-((S)-1-cyano-2-((R)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((3-Chlorophenyl)-L-propanylamino)-N-((R)-1-cyano-2-((S)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((3-Chlorophenyl)-L-propanylamino)-N-((R)-1-cyano-2-((R)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((3-Chlorophenyl)-D-propanylamino)-N-((S)-1-cyano-2-((S)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((3-Chlorophenyl)-D-propanylamino)-N-((S)-1-cyano-2-((R)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((3-Chlorophenyl)-D-propanylamino)-N-((R)-1-cyano-2-((S)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((3-Chlorophenyl)-D-propanylamino)-N-((R)-1-cyano-2-((R)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((3-Chlorophenyl)-L-propanylamino)-N-((S)-1-cyano-2-((S)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((3-Chlorophenyl)-L-propanylamino)-N-((S)-1-cyano-2-((R)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((3-Chlorophenyl)-L-propanylamino)-N-((R)-1-cyano-2-((S)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((3-Chlorophenyl)-L-propanylamino)-N-((R)-1-cyano-2-((R)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((3-Chlorophenyl)-D-propanylamino)-N-((S)-1-cyano-2-((S)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((3-Chlorophenyl)-D-propanylamino)-N-((S)-1-cyano-2-((R)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((3-Chlorophenyl)-D-propanylamino)-N-((R)-1-cyano-2-((S)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((3-Chlorophenyl)-D-propanylamino)-N-((R)-1-cyano-2-((R)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((3-Chlorophenyl)-L-propanylamino)-N-((S)-1-cyano-2-((S)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((3-Chlorophenyl)-L-propanylamino)-N-((S)-1-cyano-2-((R)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((3-Chlorophenyl)-L-propanylamino)-N-((R)-1-cyano-2-((S)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((3-Chlorophenyl)-L-propanylamino)-N-((R)-1-cyano-2-((R)-2-oxopiper Pyridin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-2-(3-cyclopropyl-2-((1-methyl-1H-pyrazole-4 -yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide; (1S,3S,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide; (1S,3S,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide; (1S,3S,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide; (1S,3S,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide; (1S,3S,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide; (1S,3S,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide; (1S,3S,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide; (1R,3S,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide; (1R,3S,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide; (1R,3S,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide; (1R,3S,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide; (1R,3S,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide; (1R,3S,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide; (1R,3S,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide; (1R,3S,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide; (1S,3R,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide; (1S,3R,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide; (1S,3R,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide; (1S,3R,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide; (1S,3R,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide; (1S,3R,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide; (1S,3R,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide; (1S,3R,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide; (1R,3R,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide; (1R,3R,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide; (1R,3R,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide; (1R,3R,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide; (1R,3R,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide; (1R,3R,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide; (1R,3R,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide; (1R,3R,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((1-methyl-1H-pyrazol-4-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane -3-Formamide; 2-((3-Chloro-2-methylphenyl)glycyl)-N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-5,5 - Difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-N-((S)-1-cyano-2-((S)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-N-((S)-1-cyano-2-((R)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-N-((R)-1-cyano-2-((S)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-N-((R)-1-cyano-2-((R)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-N-((S)-1-cyano-2-((S)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-N-((S)-1-cyano-2-((R)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-N-((R)-1-cyano-2-((S)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-N-((R)-1-cyano-2-((R)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-N-((S)-1-cyano-2-((S)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-N-((S)-1-cyano-2-((R)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-N-((R)-1-cyano-2-((S)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-N-((R)-1-cyano-2-((R)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-N-((S)-1-cyano-2-((S)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-N-((S)-1-cyano-2-((R)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-N-((R)-1-cyano-2-((S)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-N-((R)-1-cyano-2-((R)-2- Oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; 2-(1-((3-chlorophenyl)amino)cyclopropane-1-carbonyl)-N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)- 5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-(1-((3-Chlorophenyl)amino)cyclopropane-1-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-(1-((3-Chlorophenyl)amino)cyclopropane-1-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-(1-((3-Chlorophenyl)amino)cyclopropane-1-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-(1-((3-Chlorophenyl)amino)cyclopropane-1-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-(1-((3-Chlorophenyl)amino)cyclopropane-1-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-(1-((3-Chlorophenyl)amino)cyclopropane-1-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-(1-((3-Chlorophenyl)amino)cyclopropane-1-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-(1-((3-Chlorophenyl)amino)cyclopropane-1-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-(1-((3-Chlorophenyl)amino)cyclopropane-1-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-(1-((3-Chlorophenyl)amino)cyclopropane-1-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-(1-((3-Chlorophenyl)amino)cyclopropane-1-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-(1-((3-Chlorophenyl)amino)cyclopropane-1-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-(1-((3-Chlorophenyl)amino)cyclopropane-1-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-(1-((3-Chlorophenyl)amino)cyclopropane-1-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-(1-((3-Chlorophenyl)amino)cyclopropane-1-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-(1-((3-Chlorophenyl)amino)cyclopropane-1-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl)-propanamidoyl)-2-azabicyclo [2.2.2] Octane-3-formamide; (S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-D-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-L-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-D-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-L-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-D-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-L-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-D-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-L-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-D-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-L-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-D-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-L-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-D-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-L-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-D-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-L-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-L-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-L-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-D-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-L-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-D-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-L-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-D-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-L-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-D-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-L-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-D-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-L-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-D-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-L-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-D-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-L-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-((2,5-difluorophenyl )-D-propanyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-(2-hydroxy-2-phenylacetyl)-2- Azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((S)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((R)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((S)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((R)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((S)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((R)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((S)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((R)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((S)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((R)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((S)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((R)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((S)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((R)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((S)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((R)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((S)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((R)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((S)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((R)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((S)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((R)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((S)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((R)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((S)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((R)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((S)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((R)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((S)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((R)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((S)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -((R)-2-Hydroxy-2-phenylacetyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; 2-((3-chlorophenyl)-leucyl)-N-(1-cyano-2-(2-oxopyrrolidin-3-yl)ethyl)-5,5-difluoro- 2-Azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((3-Chlorophenyl)-D-leucyl)-N-((S)-1-cyano-2-((S)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((3-Chlorophenyl)-D-leucyl)-N-((S)-1-cyano-2-((R)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((3-Chlorophenyl)-D-leucyl)-N-((R)-1-cyano-2-((S)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((3-Chlorophenyl)-D-leucyl)-N-((R)-1-cyano-2-((R)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((3-Chlorophenyl)-L-leucyl)-N-((S)-1-cyano-2-((S)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((3-Chlorophenyl)-L-leucyl)-N-((S)-1-cyano-2-((R)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((3-Chlorophenyl)-L-leucyl)-N-((R)-1-cyano-2-((S)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((3-Chlorophenyl)-L-leucyl)-N-((R)-1-cyano-2-((R)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((3-Chlorophenyl)-D-leucyl)-N-((S)-1-cyano-2-((S)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((3-Chlorophenyl)-D-leucyl)-N-((S)-1-cyano-2-((R)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((3-Chlorophenyl)-D-leucyl)-N-((R)-1-cyano-2-((S)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((3-Chlorophenyl)-D-leucyl)-N-((R)-1-cyano-2-((R)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((3-Chlorophenyl)-L-leucyl)-N-((S)-1-cyano-2-((S)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((3-Chlorophenyl)-L-leucyl)-N-((S)-1-cyano-2-((R)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((3-Chlorophenyl)-L-leucyl)-N-((R)-1-cyano-2-((S)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((3-Chlorophenyl)-L-leucyl)-N-((R)-1-cyano-2-((R)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((3-Chlorophenyl)-D-leucyl)-N-((S)-1-cyano-2-((S)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((3-Chlorophenyl)-D-leucyl)-N-((S)-1-cyano-2-((R)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((3-Chlorophenyl)-D-leucyl)-N-((R)-1-cyano-2-((S)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((3-Chlorophenyl)-D-leucyl)-N-((R)-1-cyano-2-((R)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((3-Chlorophenyl)-L-leucyl)-N-((S)-1-cyano-2-((S)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((3-Chlorophenyl)-L-leucyl)-N-((S)-1-cyano-2-((R)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((3-Chlorophenyl)-L-leucyl)-N-((R)-1-cyano-2-((S)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((3-Chlorophenyl)-L-leucyl)-N-((R)-1-cyano-2-((R)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((3-Chlorophenyl)-D-leucyl)-N-((S)-1-cyano-2-((S)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((3-Chlorophenyl)-D-leucyl)-N-((S)-1-cyano-2-((R)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((3-Chlorophenyl)-D-leucyl)-N-((R)-1-cyano-2-((S)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((3-Chlorophenyl)-D-leucyl)-N-((R)-1-cyano-2-((R)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((3-Chlorophenyl)-L-leucyl)-N-((S)-1-cyano-2-((S)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((3-Chlorophenyl)-L-leucyl)-N-((S)-1-cyano-2-((R)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((3-Chlorophenyl)-L-leucyl)-N-((R)-1-cyano-2-((S)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((3-Chlorophenyl)-L-leucyl)-N-((R)-1-cyano-2-((R)-2-oxo Pyrrolidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; N-(1-cyano-2-(2-oxopyrrolidin-3-yl)ethyl)-2-(3-cyclopropyl-2-((5-methylpyridin-3-yl)amine Base) propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1S,3S,4S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1S,3S,4S)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1S,3S,4S)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1S,3S,4S)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1S,3S,4S)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1S,3S,4S)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1S,3S,4S)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1R,3S,4R)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1R,3S,4R)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1R,3S,4R)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1R,3S,4R)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1R,3S,4R)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1R,3S,4R)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1R,3S,4R)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1R,3S,4R)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1S,3R,4S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1S,3R,4S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1S,3R,4S)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1S,3R,4S)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1S,3R,4S)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1S,3R,4S)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1S,3R,4S)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1S,3R,4S)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1R,3R,4R)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1R,3R,4R)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1R,3R,4R)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1R,3R,4R)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1R,3R,4R)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1R,3R,4R)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1R,3R,4R)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((S)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1R,3R,4R)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-((R)-3 -Cyclopropyl-2-((5-methylpyridin-3-yl)amino)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-methyl Amide; 5,5-Difluoro-N-(4-fluoro-4-(methylsulfonyl)-1-(2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2 -(9-Hydroxy-9H-fen-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-5,5-Difluoro-N-((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1S,3S,4S)-5,5-Difluoro-N-((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1S,3S,4S)-5,5-Difluoro-N-((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1S,3S,4S)-5,5-Difluoro-N-((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1S,3S,4S)-5,5-Difluoro-N-((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1S,3S,4S)-5,5-Difluoro-N-((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1S,3S,4S)-5,5-Difluoro-N-((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1S,3S,4S)-5,5-Difluoro-N-((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1R,3S,4R)-5,5-Difluoro-N-((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1R,3S,4R)-5,5-Difluoro-N-((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1R,3S,4R)-5,5-Difluoro-N-((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1R,3S,4R)-5,5-Difluoro-N-((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1R,3S,4R)-5,5-Difluoro-N-((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1R,3S,4R)-5,5-Difluoro-N-((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1R,3S,4R)-5,5-Difluoro-N-((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1R,3S,4R)-5,5-Difluoro-N-((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1S,3R,4S)-5,5-Difluoro-N-((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1S,3R,4S)-5,5-Difluoro-N-((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1S,3R,4S)-5,5-Difluoro-N-((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1S,3R,4S)-5,5-Difluoro-N-((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1S,3R,4S)-5,5-Difluoro-N-((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1S,3R,4S)-5,5-Difluoro-N-((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1S,3R,4S)-5,5-Difluoro-N-((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1S,3R,4S)-5,5-Difluoro-N-((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1R,3R,4R)-5,5-Difluoro-N-((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1R,3R,4R)-5,5-Difluoro-N-((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1R,3R,4R)-5,5-Difluoro-N-((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1R,3R,4R)-5,5-Difluoro-N-((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1R,3R,4R)-5,5-Difluoro-N-((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1R,3R,4R)-5,5-Difluoro-N-((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1R,3R,4R)-5,5-Difluoro-N-((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1R,3R,4R)-5,5-Difluoro-N-((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrole Pyridin-3-yl)but-3-en-2-yl)-2-(9-hydroxy-9H-oxene-9-carbonyl)-2-azabicyclo[2.2.2]octane-3-formyl amine; N-(4-fluoro-4-(methylsulfonyl)-1-(2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-(9-hydroxyl-9H -Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,32S,6aR)-N-((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)-2-(9-hydroxy-9H-fluorene-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; 2-(2-Acetamido-2-phenylacetyl)-N-(4-fluoro-4-(methylsulfonyl)-1-(2-oxopyrrolidin-3-yl)butyl -3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((R,E)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((R,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((R,E)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((R,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((R,E)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((R,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((R,E)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((R,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (]S,3aR,6aS)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((R,E)-4-fluoro-4-(methylsulfonyl Acyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((R,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((R,E)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((R,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((R,E)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((R,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((S)-2-Acetamido-2-phenylacetyl)-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((S,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((S,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((R,E)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((R,E)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((R)-2-Acetamido-2-phenylacetyl)-N-((R,Z)-4-fluoro-4-(methylsulfonyl Base)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; 2-(3,3-Dimethyl-2-(2,2,2-trifluoroacetylamino)butyryl)-N-(4-fluoro-4-(methylsulfonyl)-1-( 2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; 2-(3,3-Dimethyl-2-(2,2,2-trifluoroacetylamino)butyryl)-N-(4-fluoro-4-(methylsulfonyl)-1-( 2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,E) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((S,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-N-((R,Z) -4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c] Pyrrole-1-carboxamide; 2-(3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N-(4-fluoro-4-(methylsulfonyl Acyl)-1-(2-oxopyrrolidin-3-yl)but-3-en-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; 1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N- ((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)eta Hydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) Octahydrocyclopenta[c]pyrrole-1-carboxamide; 2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-(4-fluoro-4-(methylsulfonyl)-1-(2-oxopyrrolidine -3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1S,3S,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1S,3S,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1S,3S,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1S,3S,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1S,3S,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1S,3S,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1S,3S,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1R,3S,4R)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1R,3S,4R)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1R,3S,4R)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1R,3S,4R)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1R,3S,4R)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1R,3S,4R)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1R,3S,4R)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1R,3S,4R)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1S,3R,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1S,3R,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1S,3R,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1S,3R,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1S,3R,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1S,3R,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1S,3R,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1S,3R,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1R,3R,4R)-2-(7-chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1R,3R,4R)-2-(7-chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1R,3R,4R)-2-(7-chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1R,3R,4R)-2-(7-chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1R,3R,4R)-2-(7-chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1R,3R,4R)-2-(7-chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1R,3R,4R)-2-(7-chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1R,3R,4R)-2-(7-chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; 2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-(4-fluoro-4-(methylsulfonyl)-1-(2-oxopyrrolidine -3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1S,3S,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1S,3S,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1S,3S,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1S,3S,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1S,3S,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1S,3S,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1S,3S,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1R,3S,4R)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1R,3S,4R)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1R,3S,4R)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1R,3S,4R)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1R,3S,4R)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1R,3S,4R)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1R,3S,4R)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1R,3S,4R)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1S,3R,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1S,3R,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1S,3R,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1S,3R,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1S,3R,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methyl Amide; (1S,3R,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1S,3R,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1S,3R,4S)-2-(7-Chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1R,3R,4R)-2-(7-chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1R,3R,4R)-2-(7-chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1R,3R,4R)-2-(7-chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1R,3R,4R)-2-(7-chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1R,3R,4R)-2-(7-chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1R,3R,4R)-2-(7-chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1R,3R,4R)-2-(7-chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; (1R,3R,4R)-2-(7-chloro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methyl Sulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-methan Amide; 2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-(4-fluoro-4-(methylsulfonyl)-1-(2-oxo Pyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide; (1S,3S,4S)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2,yl)-2-azabicyclo[2.2.2]octane- 3-formamide; (1S,3S,4S)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide; (1S,3S,4S)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide; (1S,3S,4S)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide; (1S,3S,4S)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide; (1S,3S,4S)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide; (1S,3S,4S)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide; (1R,3S,4R)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide; (1R,3S,4R)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide; (1R,3S,4R)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide; (1R,3S,4R)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide; (1R,3S,4R)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide; (1R,3S,4R)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide; (1R,3S,4R)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide; (1R,3S,4R)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide; (1S,3R,4S)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide; (1S,3R,4S)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide; (1S,3R,4S)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide; (1S,3R,4S)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide; (1S,3R,4S)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide; (1S,3R,4S)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide; (1S,3R,4S)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide; (1S,3R,4S)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide; (1R,3R,4R)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide; (1R,3R,4R)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,E)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide; (1R,3R,4R)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide; (1R,3R,4R)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide; (1R,3R,4R)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide; (1R,3R,4R)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,E)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide; (1R,3R,4R)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4- (Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide; (1R,3R,4R)-2-(4,7-Difluoro-1H-indole-2-carbonyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4- (Methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane- 3-formamide; 2-(3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N-(4-fluoro-4-(methylsulfonyl Acyl)-1-(2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-(3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N-((S , E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-nitrogen Heterobicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((S,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,E)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((R)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)butyryl)-5,5-difluoro-N -((R,Z)-4-fluoro-4-(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl) -2-Azabicyclo[2.2.2]octane-3-carboxamide; 4-(2-((3-Chlorophenyl)-D-leucylamino)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-formamido)- Ethyl 2-fluoro-5-(2-oxopyrrolidin-3-yl)pent-2-enoate; (S,Z)-4-((1S,3S,4S)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (S,Z)-4-((1S,3S,4S)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (S,Z)-4-((1S,3S,4S)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (S,Z)-4-((1S,3S,4S)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (S,Z)-4-((1R,3S,4R)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (S,Z)-4-((1R,3S,4R)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (S,Z)-4-((1R,3S,4R)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (S,Z)-4-((1R,3S,4R)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (S,Z)-4-((1S,3R,4S)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (S,Z)-4-((1S,3R,4S)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (S,Z)-4-((1S,3R,4S)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (S,Z)-4-((1S,3R,4S)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (S,Z)-4-((1R,3R,4R)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (S,Z)-4-((1R,3R,4R)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (S,Z)-4-((1R,3R,4R)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (S,Z)-4-((1R,3R,4R)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (S,E)-4-((1S,3S,4S)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (S,E)-4-((1S,3S,4S)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (S,E)-4-((1S,3S,4S)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (S,E)-4-((1S,3S,4S)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (S,E)-4-((1R,3S,4R)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (S,E)-4-((1R,3S,4R)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (S,E)-4-((1R,3S,4R)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (S,E)-4-((1R,3S,4R)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (S,E)-4-((1S,3R,4S)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (S,E)-4-((1S,3R,4S)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (S,E)-4-((1S,3R,4S)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (S,E)-4-((1S,3R,4S)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (S,E)-4-((1R,3R,4R)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (S,E)-4-((1R,3R,4R)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (S,E)-4-((1R,3R,4R)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (S,E)-4-((1R,3R,4R)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (R,Z)-4-((1S,3S,4S)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (R,Z)-4-((1S,3S,4S)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (R,Z)-4-((1S,3S,4S)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (R,Z)-4-((1S,3S,4S)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (R,Z)-4-((1R,3S,4R)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (R,Z)-4-((1R,3S,4R)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (R,Z)-4-((1R,3S,4R)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (R,Z)-4-((1R,3S,4R)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (R,Z)-4-((1S,3R,4S)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (R,Z)-4-((1S,3R,4S)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (R,Z)-4-((1S,3R,4S)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (R,Z)-4-((1S,3R,4S)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (R,Z)-4-((1R,3R,4R)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (R,Z)-4-((1R,3R,4R)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (R,Z)-4-((1R,3R,4R)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (R,Z)-4-((1R,3R,4R)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (R,E)-4-((1S,3S,4S)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (R,E)-4-((1S,3S,4S)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (R,E)-4-((1S,3S,4S)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (R,E)-4-((1S,3S,4S)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (R,E)-4-((1R,3S,4R)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (R,E)-4-((1R,3S,4R)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (R,E)-4-((1R,3S,4R)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (R,E)-4-((1R,3S,4R)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (R,E)-4-((1S,3R,4S)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (R,E)-4-((1S,3R,4S)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (R,E)-4-((1S,3R,4S)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (R,E)-4-((1S,3R,4S)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (R,E)-4-((1R,3R,4R)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (R,E)-4-((1R,3R,4R)-2-((3-chlorophenyl)-D-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (R,E)-4-((1R,3R,4R)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (R,E)-4-((1R,3R,4R)-2-((3-chlorophenyl)-L-leucyl)-5,5-difluoro-2-azabicyclo[2.2 .2] Octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; 4-(2-(3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl)-5,5-difluoro-2-azabicyclo[2.2.2] Octane-3-formamido)-2-fluoro-5-(2-oxopyrrolidin-3-yl)pent-2-enoic acid ethyl ester; (S,Z)-4-((1S,3S,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (S,Z)-4-((1S,3S,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (S,Z)-4-((1S,3S,4S)-2-((R)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (S,Z)-4-((1S,3S,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (S,Z)-4-((1R,3S,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (S,Z)-4-((1R,3S,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (S,Z)-4-((1R,3S,4R)-2-((R)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (S,Z)-4-((1R,3S,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (S,Z)-4-((1S,3R,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (S,Z)-4-((1S,3R,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (S,Z)-4-((1S,3R,4S)-2-((R)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (S,Z)-4-((1S,3R,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (S,Z)-4-((1R,3R,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (S,Z)-4-((1R,3R,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (S,Z)-4-((1R,3R,4R)-2-((R)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (S,Z)-4-((1R,3R,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (S,E)-4-((1S,3S,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (S,E)-4-((1S,3S,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (S,E)-4-((1S,3S,4S)-2-((R)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (S,E)-4-((1S,3S,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (S,E)-4-((1R,3S,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (S,E)-4-((1R,3S,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (S,E)-4-((1R,3S,4R)-2-((R)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (S,E)-4-((1R,3S,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (S,E)-4-((1S,3R,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (S,E)-4-((1S,3R,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (S,E)-4-((1S,3R,4S)-2-((R)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (S,E)-4-((1S,3R,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (S,E)-4-((1R,3R,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (S,E)-4-((1R,3R,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (S,E)-4-((1R,3R,4R)-2-((R)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (S,E)-4-((1R,3R,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (R,Z)-4-((1S,3S,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (R,Z)-4-((1S,3S,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (R,Z)-4-((1S,3S,4S)-2-((R)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (R,Z)-4-((1S,3S,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (R,Z)-4-((1R,3S,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (R,Z)-4-((1R,3S,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (R,Z)-4-((1R,3S,4R)-2-((R)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (R,Z)-4-((1R,3S,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (R,Z)-4-((1S,3R,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (R,Z)-4-((1S,3R,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (R,Z)-4-((1S,3R,4S)-2-((R)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (R,Z)-4-((1S,3R,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (R,Z)-4-((1R,3R,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (R,Z)-4-((1R,3R,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (R,Z)-4-((1R,3R,4R)-2-((R)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (R,Z)-4-((1R,3R,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (R,E)-4-((1S,3S,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (R,E)-4-((1S,3S,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (R,E)-4-((1S,3S,4S)-2-((R)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (R,E)-4-((1S,3S,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (R,E)-4-((1R,3S,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (R,E)-4-((1R,3S,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (R,E)-4-((1R,3S,4R)-2-((R)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (R,E)-4-((1R,3S,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (R,E)-4-((1S,3R,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (R,E)-4-((1S,3R,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (R,E)-4-((1S,3R,4S)-2-((R)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (R,E)-4-((1S,3R,4S)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (R,E)-4-((1R,3R,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (R,E)-4-((1R,3R,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (R,E)-4-((1R,3R,4R)-2-((R)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((S)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; (R,E)-4-((1R,3R,4R)-2-((S)-3-cyclobutyl-2-(2,2,2-trifluoroacetamido)propionyl) -5,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamido)-2-fluoro-5-((R)-2-oxopyrrolidin-3-yl ) ethyl pent-2-enoate; 2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-(4-fluoro-4-(methylsulfonyl)-1-(2- Oxypyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((S,E)-4-fluoro-4 -(Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide; (1S,3S,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((S,E)-4-fluoro-4 -(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide; (1S,3S,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4 -(Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide; (1S,3S,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4 -(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide; (1S,3S,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((R,E)-4-fluoro-4 -(Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide; (1S,3S,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((R,E)-4-fluoro-4 -(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide; (1S,3S,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4 -(Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide; (1S,3S,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4 -(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide; (1R,3S,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((S,E)-4-fluoro-4 -(Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide; (1R,3S,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((S,E)-4-fluoro-4 -(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide; (1R,3S,4R)-2-((3-chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4 -(Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide; (1R,3S,4R)-2-((3-chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4 -(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide; (1R,3S,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((R,E)-4-fluoro-4 -(Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide; (1R,3S,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((R,E)-4-fluoro-4 -(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide; (1R,3S,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4 -(Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide; (1R,3S,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4 -(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide; (1S,3R,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((S,E)-4-fluoro-4 -(Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide; (1S,3R,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((S,E)-4-fluoro-4 -(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide; (1S,3R,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4 -(Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide; (1S,3R,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4 -(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide; (1S,3R,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((R,E)-4-fluoro-4 -(Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide; (1S,3R,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((R,E)-4-fluoro-4 -(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide; (1S,3R,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4 -(Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide; (1S,3R,4S)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4 -(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide; (1R,3R,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((S,E)-4-fluoro-4 -(Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide; (1R,3R,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((S,E)-4-fluoro-4 -(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide; (1R,3R,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4 -(Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide; (1R,3R,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4 -(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide; (1R,3R,4R)-2-((3-chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((R,E)-4-fluoro-4 -(Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide; (1R,3R,4R)-2-((3-chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((R,E)-4-fluoro-4 -(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide; (1R,3R,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4 -(Methylsulfonyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide; (1R,3R,4R)-2-((3-Chloro-2-methylphenyl)glycyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4 -(methylsulfonyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane -3-Formamide; 2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-(4-fluoro-4-(methylsulfonyl)-1-(2-oxopyrrolidine- 3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methylsulfonyl Acyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1S,3S,4S)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methylsulfonyl Acyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1S,3S,4S)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methylsulfonyl Acyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1S,3S,4S)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methylsulfonyl Acyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1S,3S,4S)-2-((3-Chlorophenyl)glycinyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methylsulfonyl Acyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1S,3S,4S)-2-((3-Chlorophenyl)glycinyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methylsulfonyl Acyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1S,3S,4S)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methylsulfonyl Acyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1S,3S,4S)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methylsulfonyl Acyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1R,3S,4R)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methylsulfonyl Acyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1R,3S,4R)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methylsulfonyl Acyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1R,3S,4R)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methylsulfonyl Acyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1R,3S,4R)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methylsulfonyl Acyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1R,3S,4R)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methylsulfonyl Acyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1R,3S,4R)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methylsulfonyl Acyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1R,3S,4R)-2-((3-Chlorophenyl)glycinyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methylsulfonyl Acyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1R,3S,4R)-2-((3-Chlorophenyl)glycinyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methylsulfonyl Acyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1S,3R,4S)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methylsulfonyl Acyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1S,3R,4S)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methylsulfonyl Acyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1S,3R,4S)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methylsulfonyl Acyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1S,3R,4S)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methylsulfonyl Acyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1S,3R,4S)-2-((3-Chlorophenyl)glycinyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methylsulfonyl Acyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1S,3R,4S)-2-((3-Chlorophenyl)glycinyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methylsulfonyl Acyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1S,3R,4S)-2-((3-Chlorophenyl)glycinyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methylsulfonyl Acyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1S,3R,4S)-2-((3-Chlorophenyl)glycinyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methylsulfonyl Acyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1R,3R,4R)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methylsulfonyl Acyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1R,3R,4R)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((S,E)-4-fluoro-4-(methylsulfonyl Acyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1R,3R,4R)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methylsulfonyl Acyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1R,3R,4R)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((S,Z)-4-fluoro-4-(methylsulfonyl Acyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1R,3R,4R)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methylsulfonyl Acyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1R,3R,4R)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((R,E)-4-fluoro-4-(methylsulfonyl Acyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1R,3R,4R)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methylsulfonyl Acyl)-1-((S)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine; (1R,3R,4R)-2-((3-Chlorophenyl)glycyl)-5,5-difluoro-N-((R,Z)-4-fluoro-4-(methylsulfonyl Acyl)-1-((R)-2-oxopyrrolidin-3-yl)but-3-en-2-yl)-2-azabicyclo[2.2.2]octane-3-formyl amine; 8-(4-fluoro-1H-indole-2-carbonyl)-N-(4-fluoro-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl )-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide; 8-(4-fluoro-1H-indole-2-carbonyl)-N-((S)-4-fluoro-3-oxo-1-((S)-2-oxopyrrolidine-3- Base) butane-2-yl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide; (S)-8-(4-fluoro-1H-indole-2-carbonyl)-N-((S)-4-fluoro-3-oxo-1-((S)-2-oxopyrrole Pyridin-3-yl)butan-2-yl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide; (S)-8-(4-fluoro-1H-indole-2-carbonyl)-N-((S)-4-fluoro-3-oxo-1-((R)-2-oxopyrrole Pyridin-3-yl)butan-2-yl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide; (S)-8-(4-fluoro-1H-indole-2-carbonyl)-N-((R)-4-fluoro-3-oxo-1-((S)-2-oxopyrrole Pyridin-3-yl)butan-2-yl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide; (S)-8-(4-fluoro-1H-indole-2-carbonyl)-N-((R)-4-fluoro-3-oxo-1-((R)-2-oxopyrrole Pyridin-3-yl)butan-2-yl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide; (R)-8-(4-fluoro-1H-indole-2-carbonyl)-N-((S)-4-fluoro-3-oxo-1-((S)-2-oxopyrrole Pyridin-3-yl)butan-2-yl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide; (R)-8-(4-fluoro-1H-indole-2-carbonyl)-N-((S)-4-fluoro-3-oxo-1-((R)-2-oxopyrrole Pyridin-3-yl)butan-2-yl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide; (R)-8-(4-fluoro-1H-indole-2-carbonyl)-N-((R)-4-fluoro-3-oxo-1-((S)-2-oxopyrrole Pyridin-3-yl)butan-2-yl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide; (R)-8-(4-fluoro-1H-indole-2-carbonyl)-N-((R)-4-fluoro-3-oxo-1-((R)-2-oxopyrrole Pyridin-3-yl)butan-2-yl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide; 8-(7-Chloro-1H-indole-2-carbonyl)-N-(4-fluoro-3-oxo-1-(2-oxopyrrolidin-3-yl)butane-2-yl )-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide; 8-(7-Chloro-1H-indole-2-carbonyl)-N-((S)-4-fluoro-3-oxo-1-((S)-2-oxopyrrolidine-3- Base) butane-2-yl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide; (S)-8-(7-chloro-1H-indole-2-carbonyl)-N-((S)-4-fluoro-3-oxo-1-((S)-2-oxopyrrole Pyridin-3-yl)butan-2-yl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide; (S)-8-(7-chloro-1H-indole-2-carbonyl)-N-((S)-4-fluoro-3-oxo-1-((R)-2-oxopyrrole Pyridin-3-yl)butan-2-yl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide; (S)-8-(7-chloro-1H-indole-2-carbonyl)-N-((R)-4-fluoro-3-oxo-1-((S)-2-oxopyrrole Pyridin-3-yl)butan-2-yl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide; (S)-8-(7-chloro-1H-indole-2-carbonyl)-N-((R)-4-fluoro-3-oxo-1-((R)-2-oxopyrrole Pyridin-3-yl)butan-2-yl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide; (R)-8-(7-chloro-1H-indole-2-carbonyl)-N-((S)-4-fluoro-3-oxo-1-((S)-2-oxopyrrole Pyridin-3-yl)butan-2-yl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide; (R)-8-(7-chloro-1H-indole-2-carbonyl)-N-((S)-4-fluoro-3-oxo-1-((R)-2-oxopyrrole Pyridin-3-yl)butan-2-yl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide; (R)-8-(7-chloro-1H-indole-2-carbonyl)-N-((R)-4-fluoro-3-oxo-1-((S)-2-oxopyrrole Pyridin-3-yl)butan-2-yl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide; (R)-8-(7-chloro-1H-indole-2-carbonyl)-N-((R)-4-fluoro-3-oxo-1-((R)-2-oxopyrrole Pyridin-3-yl)butan-2-yl)-5-oxa-8-azaspiro[3.5]nonane-9-carboxamide; 2-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-5,5-difluoro-N-(4-fluoro-3-oxo-1-(2-oxo Pyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-5,5-difluoro-N-((S)-4-fluoro- 3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ; (1S,3S,4S)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-5,5-difluoro-N-((S)-4-fluoro- 3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ; (1S,3S,4S)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-5,5-difluoro-N-((R)-4-fluoro- 3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ; (1S,3S,4S)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-5,5-difluoro-N-((R)-4-fluoro- 3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ; (1R,3S,4R)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-5,5-difluoro-N-((S)-4-fluoro- 3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ; (1R,3S,4R)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-5,5-difluoro-N-((S)-4-fluoro- 3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ; (1R,3S,4R)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-5,5-difluoro-N-((R)-4-fluoro- 3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ; (1R,3S,4R)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-5,5-difluoro-N-((R)-4-fluoro- 3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ; (1S,3R,4S)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-5,5-difluoro-N-((S)-4-fluoro- 3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ; (1S,3R,4S)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-5,5-difluoro-N-((S)-4-fluoro- 3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ; (1S,3R,4S)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-5,5-difluoro-N-((R)-4-fluoro- 3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ; (1S,3R,4S)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-5,5-difluoro-N-((R)-4-fluoro- 3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ; (1R,3R,4R)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-5,5-difluoro-N-((S)-4-fluoro- 3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ; (1R,3R,4R)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-5,5-difluoro-N-((S)-4-fluoro- 3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ; (1R,3R,4R)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-5,5-difluoro-N-((R)-4-fluoro- 3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ; (1R,3R,4R)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-5,5-difluoro-N-((R)-4-fluoro- 3-oxo-1-((R)-2-oxopyrrolidin-3-yl)butane-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide ; 2-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-N-(4-fluoro-3-oxo-1-(2-oxopyrrolidin-3-yl) )butane-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-N-((S)-4-fluoro-3-oxo-1 -((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-N-((S)-4-fluoro-3-oxo-1 -((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-N-((R)-4-fluoro-3-oxo-1 -((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-N-((R)-4-fluoro-3-oxo-1 -((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-N-((S)-4-fluoro-3-oxo-1 -((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-N-((S)-4-fluoro-3-oxo-1 -((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-N-((R)-4-fluoro-3-oxo-1 -((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-N-((R)-4-fluoro-3-oxo-1 -((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-N-((S)-4-fluoro-3-oxo-1 -((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-N-((S)-4-fluoro-3-oxo-1 -((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-N-((R)-4-fluoro-3-oxo-1 -((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-N-((R)-4-fluoro-3-oxo-1 -((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-N-((S)-4-fluoro-3-oxo-1 -((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-N-((S)-4-fluoro-3-oxo-1 -((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-N-((R)-4-fluoro-3-oxo-1 -((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-2-(2-(3-Chlorophenyl)-2,2-difluoroacetyl)-N-((R)-4-fluoro-3-oxo-1 -((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; 2-(2-(3-fluorophenyl)-2,2-difluoroacetyl)-N-(4-fluoro-3-oxo-1-(2-oxopyrrolidin-3-yl) )butane-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(2-(3-fluorophenyl)-2,2-difluoroacetyl)-N-((S)-4-fluoro-3-oxo-1 -((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(2-(3-fluorophenyl)-2,2-difluoroacetyl)-N-((S)-4-fluoro-3-oxo-1 -((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(2-(3-fluorophenyl)-2,2-difluoroacetyl)-N-((R)-4-fluoro-3-oxo-1 -((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(2-(3-fluorophenyl)-2,2-difluoroacetyl)-N-((R)-4-fluoro-3-oxo-1 -((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-(2-(3-fluorophenyl)-2,2-difluoroacetyl)-N-((S)-4-fluoro-3-oxo-1 -((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-(2-(3-fluorophenyl)-2,2-difluoroacetyl)-N-((S)-4-fluoro-3-oxo-1 -((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-(2-(3-fluorophenyl)-2,2-difluoroacetyl)-N-((R)-4-fluoro-3-oxo-1 -((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-(2-(3-fluorophenyl)-2,2-difluoroacetyl)-N-((R)-4-fluoro-3-oxo-1 -((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-2-(2-(3-fluorophenyl)-2,2-difluoroacetyl)-N-((S)-4-fluoro-3-oxo-1 -((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-2-(2-(3-fluorophenyl)-2,2-difluoroacetyl)-N-((S)-4-fluoro-3-oxo-1 -((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-2-(2-(3-fluorophenyl)-2,2-difluoroacetyl)-N-((R)-4-fluoro-3-oxo-1 -((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-2-(2-(3-fluorophenyl)-2,2-difluoroacetyl)-N-((R)-4-fluoro-3-oxo-1 -((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-2-(2-(3-fluorophenyl)-2,2-difluoroacetyl)-N-((S)-4-fluoro-3-oxo-1 -((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-2-(2-(3-fluorophenyl)-2,2-difluoroacetyl)-N-((S)-4-fluoro-3-oxo-1 -((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6a,R)-2-(2-(3-fluorophenyl)-2,2-difluoroacetyl)-N-((R)-4-fluoro-3-oxo -1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-2-(2-(3-fluorophenyl)-2,2-difluoroacetyl)-N-((R)-4-fluoro-3-oxo-1 -((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; 2-(2-Fluoro-2-(3-fluorophenyl)propionyl)-N-(4-fluoro-3-oxo-1-(2-oxopyrrolidin-3-yl)butane -2-yl) octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(2-fluoro-2-(3-fluorophenyl)propionyl)-N-((S)-4-fluoro-3-oxo-1-(( S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((S)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((S)-4-fluoro-3-oxo- 1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((S)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((S)-4-fluoro-3-oxo- 1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((S)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((R)-4-fluoro-3-oxo- 1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((S)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((R)-4-fluoro-3-oxo- 1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((R)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((S)-4-fluoro-3-oxo- 1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((R)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((S)-4-fluoro-3-oxo- 1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((R)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((R)-4-fluoro-3-oxo- 1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((R)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((R)-4-fluoro-3-oxo- 1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((S)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((S)-4-fluoro-3-oxo- 1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((S)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((S)-4-fluoro-3-oxo- 1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((S)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((R)-4-fluoro-3-oxo- 1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((S)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((R)-4-fluoro-3-oxo- 1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((R)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((S)-4-fluoro-3-oxo- 1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((R)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((S)-4-fluoro-3-oxo- 1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((R)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((R)-4-fluoro-3-oxo- 1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-((R)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((R)-4-fluoro-3-oxo- 1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-2-((S)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((S)-4-fluoro-3-oxo- 1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-2-((S)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((S)-4-fluoro-3-oxo- 1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-2-((S)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((R)-4-fluoro-3-oxo- 1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-2-((S)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((R)-4-fluoro-3-oxo- 1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-2-((R)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((S)-4-fluoro-3-oxo- 1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-2-((R)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((S)-4-fluoro-3-oxo- 1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-2-((R)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((R)-4-fluoro-3-oxo- 1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-2-((R)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((R)-4-fluoro-3-oxo- 1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((S)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((S)-4-fluoro-3-oxo- 1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((S)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((S)-4-fluoro-3-oxo- 1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((S)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((R)-4-fluoro-3-oxo- 1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((S)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((R)-4-fluoro-3-oxo- 1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((R)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((S)-4-fluoro-3-oxo- 1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((R)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((S)-4-fluoro-3-oxo- 1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((R)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((R)-4-fluoro-3-oxo- 1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-2-((R)-2-fluoro-2-(3-fluorophenyl)propionyl)-N-((R)-4-fluoro-3-oxo- 1-((R)-2-oxopyrrolidin-3-yl)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; 5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-(1-(2-oxodihydrofuran-3(2H)-ylidene)- 3-(2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((S,E)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((S)-2-oxopyrrolidin-3-yl)propane-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides; (1S,3S,4S)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((S,E)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((R)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides; (1S,3S,4S)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((S,Z)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides; (1S,3S,4S)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((S,Z)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((R)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides; (1S,3S,4S)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((R,E)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((S)-2-oxopyrrolidin-3-yl)propane-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides; (1S,3S,4S)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((R,E)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((R)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides; (1S,3S,4S)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((R,Z)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((S)-2-oxopyrrolidin-3-yl)propane-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides; (1S,3S,4S)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((R,Z)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((R)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides; (1R,3S,4R)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((S,E)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((S)-2-oxopyrrolidin-3-yl)propane-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides; (1R,3S,4R)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((S,E)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((R)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides; (1R,3S,4R)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((S,Z)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides; (1R,3S,4R)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((S,Z)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((R)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides; (1R,3S,4R)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((R,E)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides; (1R,3S,4R)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((R,E)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((R)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides; (1R,3S,4R)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((R,Z)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides; (1R,3S,4R)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((R,Z)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((R)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides; (1S,3R,4S)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((S,E)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides; (1S,3R,4S)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((S,E)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((R)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides; (1S,3R,4S)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((S,Z)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides; (1S,3R,4S)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((S,Z)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((R)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides; (1S,3R,4S)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((R,E)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides; (1S,3R,4S)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((R,E)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((R)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides; (1S,3R,4S)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((R,Z)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides; (1S,3R,4S)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((R,Z)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((R)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides; (1R,3R,4R)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((S,E)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides; (1R,3R,4R)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((S,E)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((R)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides; (1R,3R,4R)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((S,Z)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((S)-2-oxopyrrolidin-3-yl)propane-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides; (1R,3R,4R)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((S,Z)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((R)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides; (1R,3R,4R)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((R,E)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides; (1R,3R,4R)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((R,E)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((R)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides; (1R,3R,4R)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((R,Z)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides; (1R,3R,4R)-5,5-Difluoro-2-(4-methoxy-1H-indole-2-carbonyl)-N-((R,Z)-1-(2-oxo Dihydrofuran-3(2H)-ylidene)-3-((R)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-azabicyclo[2.2.2]octane Alkane-3-carboxamides; 2-(2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-5,5- Difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-(2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((S)-2-oxo Piperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((S)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((S)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((S)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((S)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((R)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((R)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((R)-2-Bromo-9-hydroxyl-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-2-((R)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((S)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((S)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((S)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((S)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((R)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((R)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((R)-2-Bromo-9-hydroxyl-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-2-((R)-2-Bromo-9-hydroxyl-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((S)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((S)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((S)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((S)-2-Bromo-9-hydroxyl-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((R)-2-Bromo-9-hydroxyl-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((R)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((R)-2-Bromo-9-hydroxyl-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-2-((R)-2-Bromo-9-hydroxyl-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((S)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((S)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiper-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((S)-2-Bromo-9-hydroxyl-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((S)-2-Bromo-9-hydroxy-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((R)-2-Bromo-9-hydroxyl-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((R)-2-Bromo-9-hydroxyl-9H-fennel-9-carbonyl)-N-((S)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((R)-2-bromo-9-hydroxyl-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((S) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-2-((R)-2-bromo-9-hydroxyl-9H-fennel-9-carbonyl)-N-((R)-1-cyano-2-((R) -2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-2-(2,7-difluoro-9-hydroxy-9H-fennel-9-carbonyl)-5 ,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamide; (1S,3S,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Fluoro-9-hydroxy-9H-fluorene-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Fluoro-9-hydroxy-9H-fluorene-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Fluoro-9-hydroxy-9H-fluorene-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Fluoro-9-hydroxy-9H-fluorene-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Fluoro-9-hydroxy-9H-fluorene-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Fluoro-9-hydroxy-9H-fluorene-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Fluoro-9-hydroxy-9H-fluorene-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Fluoro-9-hydroxy-9H-fluorene-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Fluoro-9-hydroxy-9H-fluorene-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Fluoro-9-hydroxy-9H-fluorene-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Fluoro-9-hydroxy-9H-fluorene-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Fluoro-9-hydroxy-9H-fluorene-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Fluoro-9-hydroxy-9H-fluorene-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Fluoro-9-hydroxy-9H-fluorene-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Fluoro-9-hydroxy-9H-fluorene-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Fluoro-9-hydroxy-9H-fluorene-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-2-(2,7-dichloro-9-hydroxy-9H-fennel-9-carbonyl)-5 ,5-Difluoro-2-azabicyclo[2.2.2]octane-3-formamide; (1S,3S,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Chloro-9-hydroxy-9H-fennel-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Chloro-9-hydroxy-9H-fennel-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Chloro-9-hydroxy-9H-fennel-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3S,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Chloro-9-hydroxy-9H-fennel-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Chloro-9-hydroxy-9H-fennel-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Chloro-9-hydroxy-9H-fennel-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Chloro-9-hydroxy-9H-fennel-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3S,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Chloro-9-hydroxy-9H-fennel-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Chloro-9-hydroxy-9H-fennel-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Chloro-9-hydroxy-9H-fennel-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Chloro-9-hydroxy-9H-fennel-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1S,3R,4S)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Chloro-9-hydroxy-9H-fennel-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Chloro-9-hydroxy-9H-fennel-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Chloro-9-hydroxy-9H-fennel-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Chloro-9-hydroxy-9H-fennel-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; (1R,3R,4R)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(2,7-di Chloro-9-hydroxy-9H-fennel-9-carbonyl)-5,5-difluoro-2-azabicyclo[2.2.2]octane-3-carboxamide; N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-(9-hydroxy-9H-fennel-9-carbonyl)octahydro Cyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2-(4-fluoro-1H-indole-2-carbonyl)eta Hydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(4-fluoro-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(4-fluoro-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(4-fluoro-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(4-fluoro-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(4-fluoro-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(4-fluoro-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(4-fluoro-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(4-fluoro-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(4-fluoro-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(4-fluoro-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(4-fluoro-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(4-fluoro-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(4-fluoro-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(4-fluoro-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(4-fluoro-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-5,5-difluoro-2 -(4-fluoro-1H-indole-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoromethyl)-6-fluoro-1H-indole-2-carbonyl )-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-6-fluoro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoromethyl)-7-chloro-1H-indole-2-carbonyl )-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-(difluoro Methyl)-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-2-(4,7-difluoro-6-chloro-1H-indole-2-carbonyl)- 5,5-Difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; 2-(3-Chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl) -5,5-Difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(3-Chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-1-cyano-2-((S )-2-oxopiperidin-3-yl)ethyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(3-Chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-1-cyano-2-((R )-2-oxopiperidin-3-yl)ethyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-1-cyano-2-((S )-2-oxopiperidin-3-yl)ethyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-1-cyano-2-((R )-2-oxopiperidin-3-yl)ethyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-(3-Chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-1-cyano-2-((S )-2-oxopiperidin-3-yl)ethyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-(3-Chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-1-cyano-2-((R )-2-oxopiperidin-3-yl)ethyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-1-cyano-2-((S )-2-oxopiperidin-3-yl)ethyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-2-(3-Chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-1-cyano-2-((R )-2-oxopiperidin-3-yl)ethyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-1-cyano-2-((S )-2-oxopiperidin-3-yl)ethyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-1-cyano-2-((R )-2-oxopiperidin-3-yl)ethyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-1-cyano-2-((S )-2-oxopiperidin-3-yl)ethyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-1-cyano-2-((R )-2-oxopiperidin-3-yl)ethyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-1-cyano-2-((S )-2-oxopiperidin-3-yl)ethyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((S)-1-cyano-2-((R )-2-oxopiperidin-3-yl)ethyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-1-cyano-2-((S )-2-oxopiperidin-3-yl)ethyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-2-(3-chloro-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-((R)-1-cyano-2-((R )-2-oxopiperidin-3-yl)ethyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-2-(4,6-difluoro-7-chloro-1H-indole-2-carbonyl)- 5,5-Difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,6-di Fluoro-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,6-di Fluoro-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,6-di Fluoro-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,6-di Fluoro-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,6-di Fluoro-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,6-di Fluoro-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,6-di Fluoro-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,6-di Fluoro-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,6-di Fluoro-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,6-di Fluoro-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,6-di Fluoro-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,6-di Fluoro-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,6-di Fluoro-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,6-di Fluoro-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,6-di Fluoro-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,6-di Fluoro-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-6-methyl-7-chloro-1H-indole-2-carbonyl )-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-6 -Methyl-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-6 -Methyl-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-6 -Methyl-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-6 -Methyl-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-6 -Methyl-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-6 -Methyl-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-6 -Methyl-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-6 -Methyl-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-6 -Methyl-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-6 -Methyl-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-6 -Methyl-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-6 -Methyl-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-6 -Methyl-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-6 -Methyl-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-6 -Methyl-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-6 -Methyl-7-chloro-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-2-(4,7-difluoro-6-methyl-1H-indole-2-carbonyl) -5,5-Difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-methyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-methyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-methyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-methyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-methyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-methyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-methyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-methyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-methyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-methyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-methyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-methyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-methyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-methyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-methyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4,7-di Fluoro-6-methyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-7-difluoromethyl-1H-indole-2-carbonyl)- 5,5-Difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-7 -Difluoromethyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-7 -Difluoromethyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-7 -Difluoromethyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-7 -Difluoromethyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-7 -Difluoromethyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-7 -Difluoromethyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-7 -Difluoromethyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-7 -Difluoromethyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-7 -Difluoromethyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-7 -Difluoromethyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-7 -Difluoromethyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-7 -Difluoromethyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-7 -Difluoromethyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-7 -Difluoromethyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-7 -Difluoromethyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(4-fluoro-7 -Difluoromethyl-1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; N-(1-cyano-2-(2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy-1H-indole-2-carbonyl)-5,5-di Fluoroctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy -1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy -1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy -1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy -1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy -1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy -1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy -1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy -1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy -1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy -1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy -1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy -1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy -1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy -1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy -1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-methoxy -1H-indole-2-carbonyl)-5,5-difluorooctahydrocyclopenta[c]pyrrole-1-carboxamide; N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-4,4-difluoro-2-(9-hydroxy-9H-fennel-9-carbonyl)octahydro Cyclopenta[c]pyrrole-1-carboxamide; N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-4,4-difluoro-2-(9-hydroxyl-9H- Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; N-(1-cyano-2-(2-oxopyrrolidin-3-yl)ethyl)-4,4-difluoro-2-(9-hydroxy-9H-fennel-9-carbonyl)octahydro Cyclopenta[c]pyrrole-1-carboxamide; N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-4,4-difluoro-2-(9-hydroxyl-9H- Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopyrrolidin-3-yl)ethyl)-4,4-difluoro-2 -(9-hydroxy-9H-fen-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; N-(1-cyano-2-(2-oxopiperidin-3-yl)ethyl)-2-(9-hydroxy-9H-fenflure-9-carbonyl)octahydrocyclopenta[c]pyrrole- 1-formamide; N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(9-hydroxyl-9H-fennel-9-carbonyl)octa Hydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(9-hydroxyl-9H -Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(9-hydroxyl-9H -Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(9-hydroxyl-9H -Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(9-hydroxyl-9H -Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(9-hydroxyl-9H -Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(9-hydroxyl-9H -Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(9-hydroxyl-9H -Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(9-hydroxyl-9H -Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(9-hydroxyl-9H -Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(9-hydroxyl-9H -Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(9-hydroxyl-9H -Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aR,6aS)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(9-hydroxyl-9H -Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(9-hydroxyl-9H -Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((S)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(9-hydroxyl-9H -Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3aS,6aR)-N-((R)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)-2-(9-hydroxyl-9H -Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; and (1R,3aS,6aR)-N-((R)-1-cyano-2-((R)-2-oxopiperidin-3-yl)ethyl)-2-(9-hydroxyl-9H -Oxa-9-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide. A pharmaceutical composition comprising at least one compound as described in any one of claims 1 to 28 and a pharmaceutically acceptable carrier. The pharmaceutical composition according to claim 29, further comprising at least one additional medicament for treating, improving and/or preventing coronavirus infection. The pharmaceutical composition of claim 30, wherein the at least one additional agent is an inhibitor of RNA-dependent RNA polymerase (RdRp) (ie, nspl2) or a prodrug thereof. A method for treating, improving and/or preventing coronavirus infection in a subject, the method comprising administering to the subject a therapeutically effective amount of at least one compound as described in any one of claims 1 to 28 and/or Or at least one pharmaceutical composition as described in any one of claims 29 to 31. The method of claim 32, wherein at least one additional agent for treating, improving and/or preventing the coronavirus infection is further administered to the subject. The method of claim 33, wherein the at least one additional agent and the at least one compound and/or composition are co-administered to the subject. The method of claim 34, wherein the at least one additional agent is an inhibitor of RNA-dependent RNA polymerase (RdRp) (ie, nspl2) or a prodrug thereof. The method of claim 34 or 35, wherein the at least one additional medicament and the at least one compound and/or composition are co-formulated. The method according to any one of claims 32 to 36, wherein the coronavirus is selected from alphacoronaviruses and betacoronaviruses. The method of claim 37, wherein the alphacoronavirus is selected from human coronavirus 229E (HCoV-229E) and human coronavirus NL63 (HCoV-NL63). The method as claimed in claim 38, wherein the beta coronavirus is selected from severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2), severe acute respiratory syndrome-related coronavirus 1 (SARS-CoV or SARS -CoV-1), Middle East respiratory syndrome-related coronavirus (MERS-CoV), human coronavirus OC43 (HCoV-OC43) and human coronavirus HKU1 (HCoV-HKU1). The method of claim 37 or 39, wherein the beta coronavirus is SARS-CoV-2. The method according to any one of claims 32 to 40, wherein the coronavirus main protease (M ^pro ) is inhibited. The method of claim 41, wherein the M ^pro is a 3C-like protease (3CL ^pro ). The method of any one of claims 32 to 42, wherein the subject is a mammal. The method of claim 43, wherein the mammal is a human.