TW202307208A - 反義寡聚物之組合 - Google Patents

反義寡聚物之組合 Download PDF

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TW202307208A
TW202307208A TW111123470A TW111123470A TW202307208A TW 202307208 A TW202307208 A TW 202307208A TW 111123470 A TW111123470 A TW 111123470A TW 111123470 A TW111123470 A TW 111123470A TW 202307208 A TW202307208 A TW 202307208A
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TW111123470A
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戸根悠一郎
青木吉嗣
本橋紀夫
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日商日本新藥股份有限公司
國立研究開發法人國立精神 神經醫療研究中心
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Publication of TW202307208A publication Critical patent/TW202307208A/zh

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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A—HUMAN NECESSITIES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/33—Alteration of splicing

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TW111123470A 2021-06-23 2022-06-23 反義寡聚物之組合 TW202307208A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2021-104145 2021-06-23
JP2021104145 2021-06-23

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TW202307208A true TW202307208A (zh) 2023-02-16

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TW111123470A TW202307208A (zh) 2021-06-23 2022-06-23 反義寡聚物之組合

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US (1) US20240301416A1 (https=)
EP (1) EP4361269A4 (https=)
JP (1) JPWO2022270585A1 (https=)
KR (1) KR20240024176A (https=)
CN (1) CN117940564A (https=)
AU (1) AU2022298028A1 (https=)
BR (1) BR112023027298A2 (https=)
CA (1) CA3224782A1 (https=)
CO (1) CO2023016805A2 (https=)
IL (1) IL309626A (https=)
MX (1) MX2023014417A (https=)
TW (1) TW202307208A (https=)
WO (1) WO2022270585A1 (https=)

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SG11202100928QA (en) 2018-08-02 2021-02-25 Dyne Therapeutics Inc Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy
US12018087B2 (en) 2018-08-02 2024-06-25 Dyne Therapeutics, Inc. Muscle-targeting complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and methods of delivering oligonucleotide to a subject
US11168141B2 (en) 2018-08-02 2021-11-09 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating dystrophinopathies
CA3108282A1 (en) 2018-08-02 2020-02-06 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating dystrophinopathies
US12370264B1 (en) 2018-08-02 2025-07-29 Dyne Therapeutics, Inc. Complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and method of delivering oligonucleotide to a subject
US12097263B2 (en) 2018-08-02 2024-09-24 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating myotonic dystrophy
JP7780691B2 (ja) * 2020-01-10 2025-12-05 ダイン セラピューティクス，インコーポレーテッド ジストロフィン異常症を処置するための筋標的化複合体およびそれらの使用
US11771776B2 (en) 2021-07-09 2023-10-03 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating dystrophinopathies
US11969475B2 (en) 2021-07-09 2024-04-30 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy
IL316143A (en) 2022-04-15 2024-12-01 Dyne Therapeutics Inc Muscle targeting complexes and formulations for the treatment of myotonic dystrophy
US20250121085A1 (en) * 2023-10-02 2025-04-17 Avidity Biosciences, Inc. Antibody-oligonucleotide conjugate compositions and methods of inducing dmd exon 45 skipping

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AU2022298028A1 (en) 2023-12-21
EP4361269A1 (en) 2024-05-01
MX2023014417A (es) 2023-12-15
US20240301416A1 (en) 2024-09-12
JPWO2022270585A1 (https=) 2022-12-29
IL309626A (en) 2024-02-01
CN117940564A (zh) 2024-04-26
BR112023027298A2 (pt) 2024-03-12
EP4361269A4 (en) 2026-01-14
KR20240024176A (ko) 2024-02-23
CO2023016805A2 (es) 2023-12-29
WO2022270585A1 (ja) 2022-12-29
CA3224782A1 (en) 2022-12-29

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