TW202305818A - 使用電信號之鹼基修飾分析 - Google Patents

使用電信號之鹼基修飾分析 Download PDF

Info

Publication number
TW202305818A
TW202305818A TW111113903A TW111113903A TW202305818A TW 202305818 A TW202305818 A TW 202305818A TW 111113903 A TW111113903 A TW 111113903A TW 111113903 A TW111113903 A TW 111113903A TW 202305818 A TW202305818 A TW 202305818A
Authority
TW
Taiwan
Prior art keywords
nucleic acid
nucleotide
methylation
nucleotides
acid molecule
Prior art date
Application number
TW111113903A
Other languages
English (en)
Chinese (zh)
Inventor
煜明 盧
慧君 趙
君賜 陳
江培勇
淑恒 鄭
鄧佳恩
Original Assignee
香港中文大學
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 香港中文大學 filed Critical 香港中文大學
Publication of TW202305818A publication Critical patent/TW202305818A/zh

Links

Images

Classifications

    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20Supervised data analysis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/10Signal processing, e.g. from mass spectrometry [MS] or from PCR
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2563/00Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/116Nucleic acid detection characterized by the use of physical, structural and functional properties electrical properties of nucleic acids, e.g. impedance, conductivity or resistance
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/154Methylation markers
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/10Ploidy or copy number detection
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10Sequence alignment; Homology search

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Theoretical Computer Science (AREA)
  • Evolutionary Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Data Mining & Analysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Databases & Information Systems (AREA)
  • Artificial Intelligence (AREA)
  • Public Health (AREA)
  • Evolutionary Computation (AREA)
  • Epidemiology (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Bioethics (AREA)
  • Software Systems (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Signal Processing (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
TW111113903A 2021-04-12 2022-04-12 使用電信號之鹼基修飾分析 TW202305818A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202163173728P 2021-04-12 2021-04-12
US63/173,728 2021-04-12

Publications (1)

Publication Number Publication Date
TW202305818A true TW202305818A (zh) 2023-02-01

Family

ID=83509521

Family Applications (1)

Application Number Title Priority Date Filing Date
TW111113903A TW202305818A (zh) 2021-04-12 2022-04-12 使用電信號之鹼基修飾分析

Country Status (10)

Country Link
US (1) US20220328135A1 (https=)
EP (1) EP4323539A4 (https=)
JP (1) JP2024516365A (https=)
KR (1) KR20240007159A (https=)
CN (1) CN117545855A (https=)
AU (1) AU2022258155A1 (https=)
CA (1) CA3215066A1 (https=)
IL (1) IL307398A (https=)
TW (1) TW202305818A (https=)
WO (1) WO2022218290A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112481363A (zh) * 2020-03-09 2021-03-12 南京大学 突变Aerolysin单体在检测RNA碱基序列及RNA修饰方面的应用

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115620809B (zh) * 2022-12-16 2023-04-07 北京齐碳科技有限公司 纳米孔测序数据分析方法、装置以及存储介质和应用
US20240203530A1 (en) * 2022-12-16 2024-06-20 Centre For Novostics Machine learning techniques to determine base methylations
JPWO2024247764A1 (https=) * 2023-05-30 2024-12-05
CN117831630B (zh) * 2024-03-05 2024-05-17 北京普译生物科技有限公司 为碱基识别模型构建训练数据集的方法、装置及电子设备

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002318336A1 (en) * 2001-06-08 2002-12-23 U.S. Genomics, Inc. Methods and products for analyzing nucleic acids based on methylation status
WO2008047234A1 (en) * 2006-10-18 2008-04-24 Epigenomics Ag A molecule for providing a standard for the quantitative analysis of the methylation status of a nucleic acid
WO2008070144A2 (en) * 2006-12-06 2008-06-12 Duke University Imprinted genes and disease
US9238836B2 (en) * 2012-03-30 2016-01-19 Pacific Biosciences Of California, Inc. Methods and compositions for sequencing modified nucleic acids
CA2995422A1 (en) * 2015-08-12 2017-02-16 The Chinese University Of Hong Kong Single-molecule sequencing of plasma dna
GB201819378D0 (en) * 2018-11-28 2019-01-09 Oxford Nanopore Tech Ltd Analysis of nanopore signal using a machine-learning technique
WO2020236995A1 (en) * 2019-05-22 2020-11-26 Icahn School Of Medicine At Mount Sinai Method for de novo detection, identification and fine mapping of multiple forms of nucleic acid modifications
TWI752593B (zh) * 2019-08-16 2022-01-11 香港中文大學 核酸鹼基修飾的測定

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112481363A (zh) * 2020-03-09 2021-03-12 南京大学 突变Aerolysin单体在检测RNA碱基序列及RNA修饰方面的应用
CN112481363B (zh) * 2020-03-09 2024-05-28 南京大学 突变Aerolysin单体在检测RNA碱基序列及RNA修饰方面的应用

Also Published As

Publication number Publication date
CN117545855A (zh) 2024-02-09
IL307398A (en) 2023-12-01
EP4323539A4 (en) 2025-02-05
KR20240007159A (ko) 2024-01-16
EP4323539A1 (en) 2024-02-21
JP2024516365A (ja) 2024-04-15
US20220328135A1 (en) 2022-10-13
AU2022258155A1 (en) 2023-11-30
CA3215066A1 (en) 2022-10-20
WO2022218290A1 (en) 2022-10-20

Similar Documents

Publication Publication Date Title
JP7462993B2 (ja) 核酸の塩基修飾の決定
TW202305818A (zh) 使用電信號之鹼基修飾分析
KR20220118551A (ko) 임신 중 긴 세포유리 단편을 사용한 분자 분석
GB2636509A (en) Fragmentation for measuring methylation and disease
JP2021531016A (ja) 無細胞dna損傷分析およびその臨床応用
WO2023093782A1 (en) Molecular analyses using long cell-free dna molecules for disease classification
TW202439326A (zh) 用於確定鹼基甲基化的機器學習技術
HK40108820A (zh) 使用电信号的碱基修饰分析
HK40120384A (zh) 用於测量甲基化和疾病的片段化
HK40044336B (en) Determination of base modifications of nucleic acids