TW202237667A - Her-2 targeted bispecific compositions and methods for making and using the same - Google Patents

Abstract

Disclosed herein are polypeptides, and methods of making and using such polypeptides, that comprise a bispecific antibody construct covalently linked to an extended recombinant polypeptide comprising a barcode fragment releasable from said polypeptide upon digestion by a protease, and a Release Segment that can be proteolytically cleaved wherein said cleavage releases the bispecific antibody construct from the extended recombinant polypeptide.

Description

Bispecific composition targeting HER-2 and methods of making and using same

Bispecific T-cell engager (TCE) presents a potent modality for cancer therapy that redirects T-cell cytotoxicity against tumors expressing selected tumor-associated antigens, bypassing the requirement for T-cell recognition of tumor antigens . The activity of a TCE is determined by its ability to activate T cells by potently stimulating the T cell receptor (TCR). The extreme potency of TCEs derives from the minimal requirement for as few as 3 TCRs to become stimulated and coalesce to form an immune synapse between T cells and target cells to elicit cytotoxicity. In addition to TCE-induced cytotoxicity, the potency of TCE also involves cytokine-driven effects downstream of T cell activation that enhance and amplify anti-tumor immune responses. Thus, TCEs offer immunotherapy promise to patients whose tumors are insufficiently mutated or otherwise escape immune surveillance. However, this modality is not without its own challenges, and the use of TCEs in solid tumors is limited by their extreme potency and on-target, off-tumor toxicity in healthy tissues.

TCEs are highly effective in inducing remission in patients with hematologic cancers, but their use in solid tumors is limited by their extreme potency and on-target toxicity against normal tissues expressing even low levels of the target. Impressive but rare clinical responses have been observed for tumors typically refractory to immunotherapy (e.g., microsatellite stable colorectal and prostate cancers), but toxicities such as interleukin release syndrome have been observed at low doses Prevent dose escalation to reveal modality clinical potential. The grade 4 cytokine release syndrome induced in patients treated with Ichnos ISB 1302 HER2 TCE at doses < 1 μg/kg underscores the challenges faced by TCE even when targeting relatively tissue-restricted targets.

Clinical trials with blinatumomab, an approved CD3xCD19 bispecific antibody, revealed that cytokine release syndrome (CRS) was one of the major safety-related adverse events. CRS and on-target toxicity at low drug doses significantly impair therapeutic index and TCE modality potential in the clinic against solid tumors. For example, a clinical trial for catumaxomab (CD3xEpCAM) was terminated due to drug-associated liver failure at the 10 μg dose. In another trial, the dose of a HER2-targeted TCE (Glenmark GBR1302) agent was limited to less than 1 μg/kg due to the onset of G4 CRS. Although pasotuxumab (TCE targeting PSMA) showed good response, it was hampered by CRS at doses greater than 40 μg/day. The literature is replete with other examples of on-target toxicity challenges presented by CRS and TCE.

Attempts to circumvent CRS have included complex molecular design, but these attempts have been unsuccessful due to toxicity and/or enhanced immunogenicity. This presents a significant unmet need for new strategies that can overcome the therapeutic index challenge in solid tumors. If the potency of TCEs can be harnessed and the CRS can be controlled and on-target toxicity challenges, it may be possible to generate potent therapeutics that can potentially be used against a broad spectrum of cancers.

Therapeutic agents, such as drug substances, include polypeptides that can be produced in such a way that a mixture of polypeptides can affect the activity of the drug substance. Polypeptide mixtures typically can include full-length polypeptides as well as size variants (eg, truncations) thereof. The presence of variants that differ in size from the desired full-length product may affect the biological status of the drug substance, which may affect the safety and/or efficacy of the polypeptide drug substance. For example, protein-based prodrugs for cancer therapy can be engineered to target tumor-targeted activation mechanisms. More specifically, the full-length therapeutic protein may be in the form of an inactive (non-cytotoxic) prodrug, whereas truncated variants of the full-length construct may lose the protective sequence and become cytotoxic (active), thus "contaminating" the prodrug pharmaceutical composition. In some cases, such shorter length variants may pose a higher risk of immunogenicity, be less selectively toxic to tumor cells, or exhibit a less desirable pharmacokinetic profile than the full-length protein ( e.g. causing narrowing of the therapeutic window). Therefore, the detection and quantification of protein structure changes can be useful in the evaluation of biological properties of biotherapeutics ( such as clinical safety and pharmacological efficacy) and in the development of new biotherapeutics ( such as with improved efficacy and reduced side effects). importance. Existing techniques and methods for identifying and quantifying the amount of "contaminating" truncated products may include one or more disadvantages such as having limited sensitivity, simplicity, efficiency or effectiveness.

The present invention addresses a long-felt unmet need in providing TCE cancer therapeutics with increased therapeutic index. Accordingly, the present invention harnesses the therapeutic potential of TCEs by providing XTENylated protease-activated dual-specific T cell engagers (XPATs). XPAT represents a novel strategy for improving the toxicity profile of T cell engagers while maintaining their potency against solid tumors, thus enabling a significant increase in therapeutic index and expanded targeting prospects for this potent modality. In certain specific embodiments, the XPATs of the invention target HER2-bearing tumors. More specifically, AMX-818 is a conditionally activated prodrug TCE targeting HER2 designed to exploit dysregulated protease activity in tumors while sparing healthy tissue where protease inhibition dominates, thus widening the safety margin limit and increase the therapeutic index.

Provided herein is a polypeptide having an N-terminal amino acid and a C-terminal amino acid, the polypeptide comprising: (a) an expanded recombinant polypeptide ( XTEN ) comprising a barcode fragment ( BAR ) that can be released from the polypeptide after protease digestion; (b) a bispecific antibody construct ( BsAb ) comprising a first antigen-binding fragment ( AF1 ) specifically binding to the cluster of differentiation 3 T cell receptor (CD3), the AF1 comprising a light chain complementarity determining region 1 (CDR -L1), 2 (CDR-L2) and 3 (CDR-L3) and heavy chain complementarity determining regions 1 (CDR-H1), 2 (CDR-H2) and 3 (CDR-H3), wherein the CDR-H3 comprises The amino acid sequence of SEQ ID NO: 10 ; and the second antigen-binding fragment ( AF2 ) specifically binding to human epidermal growth factor receptor 2 (HER2); and (c) located between the XTEN and the bispecific antibody construct Release segment ( RS ) between bodies, wherein the XTEN is characterized in that: (i) it comprises at least 100 or at least 150 amino acids; (ii) at least 90% of its amino acid residues are glycine acid (G), alanine (A), serine (S), threonine (T), glutamic acid (E) or proline (P); (iii) which contain at least 4 different types of amino acids, the amino acids being G, A, S, T, E, or P; and (iv) the XTEN is formed from a plurality of non-overlapping sequence motifs, each of which is 9 to 14 in length Amino acids, wherein the plurality of non-overlapping sequence motifs comprises: (1) a set of non-overlapping sequence motifs, wherein each non-overlapping sequence motif in the set of non-overlapping sequence motifs is repeated at least twice in the XTEN and (2) a non-overlapping sequence motif that occurs only once within the XTEN; wherein the barcode segment ( BAR ) includes at least a portion of the non-overlapping sequence motif that occurs only once within the XTEN; wherein the barcode segment ( BAR ) differs from all other peptide fragments that can be released from the polypeptide after complete digestion of the polypeptide by the protease in sequence and molecular weight; and wherein the barcode fragment ( BAR ) does not include the N-terminal amino acid of the polypeptide or the C-terminal amino acid.

In certain embodiments, the set of non-overlapping sequence motifs each independently comprise an amino acid sequence identified herein by SEQ ID NO: 179-200 and 1715-1722 . In certain embodiments, the set of non-overlapping sequence motifs each independently comprise an amino acid sequence identified herein by SEQ ID NO: 186-189 . In certain embodiments, the set of non-overlapping sequence motifs comprises at least two, at least three, or all four of the sequence motifs SEQ ID NO: 186-189 . In certain embodiments, the XTEN comprises 100 to 3,000, 150 to 3,000, 100 to 1,000, or 150 to 1,000 amino acid residues in length. In certain embodiments, the XTEN comprises at least 200, at least 250, at least 300, at least 350, at least 400, at least 450, or at least 500 amino acid residues in length. In certain embodiments, at least 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% of the amino acid residues of the XTEN are glycine (G), alanine (A), serine (S), threonine (T), glutamic acid (E) or proline (P).

In certain embodiments, the XTEN has at least 90%, at least 92%, at least 95%, at least 98%, at least 99%, or 100% sequence identity to the sequences set forth in Table 3a . In certain embodiments, the barcode segment ( BAR ) does not include a glutamic acid that is immediately adjacent to another glutamic acid (if present) in the XTEN. In certain embodiments, the barcode segment ( BAR ) has glutamic acid at its C-terminus. In certain embodiments, the barcode segment ( BAR ) has an N-terminal amino acid immediately following the glutamic acid residue. In certain embodiments, the barcode segment ( BAR ) is positioned at a distance from the N-terminus of the polypeptide or the C-terminus of the polypeptide, wherein the distance is 10 to 150 amino acids or 10 to 125 amino acids acid length. In certain embodiments, the barcode segment ( BAR ) is characterized in that: (i) it does not include a glutamic acid immediately adjacent to another glutamic acid (if present) in the XTEN; (ii) it is at its C-terminus (iii) it has the N-terminal amino acid immediately following the glutamic acid residue; and (iv) it is located at a distance from the N-terminus of the polypeptide or the C-terminus of the polypeptide, Wherein the distance is 10 to 150 amino acids or 10 to 125 amino acids in length. In certain embodiments, the glutamic acid residue preceding the N-terminal amino acid of the barcode segment ( BAR ) is not immediately adjacent to another glutamic acid residue.

In certain embodiments, the barcode segment ( BAR ) does not include a second glutamic acid residue at a position other than the C-terminus of the barcode segment, unless the second glutamic acid is followed by a proline. In certain embodiments, the XTEN is located at the N-terminus of the bispecific antibody construct ( BsAb ), wherein the barcode fragment ( BAR ) is located at the N-terminal 200, 150, 100 or 50 amines of the polypeptide within the amino acid. In certain embodiments, the XTEN is located at the N-terminus of the bispecific antibody construct ( BsAb ), and wherein the barcode segment ( BAR1 ) is located between 10 and 200, 30, Between 200 and 200, between 40 and 150 or between 50 and 100 amino acid positions. In certain embodiments, the XTEN is located at the C-terminus of the bispecific antibody construct ( BsAb ), and wherein the barcode fragment ( BAR ) is located at 200, 150, 100 or 50 of the C-terminus of the polypeptide within the amino acid. In certain embodiments, the XTEN is located at the C-terminus of the bispecific antibody construct ( BsAb ), and the barcode segment ( BAR ) is located between 10 and 200, 30 and Between 200, between 40 and 150, or between 50 and 100 amino acid positions. In certain embodiments, the barcode segment ( BAR ) is at least 4 amino acids in length. In certain embodiments, the length of the barcode segment ( BAR ) is between 4 and 20, between 5 and 15, between 6 and 12, or between 7 and 10 between amino acids.

In certain embodiments, the barcode fragment ( BAR ) comprises the amino acid sequence set forth in Table 2 . In certain embodiments, the length of the XTEN is defined by a proximal end and a distal end, wherein (1) the proximal end is positioned closer to the bispecific antibody construct ( BsAb ) relative to the distal end, and wherein (2) The barcode segment ( BAR ) is located between 5% and 50%, between 7% and 40%, or between 10% and 30% of the length of the XTEN as measured from the distal end extending within the region of the XTEN. In certain embodiments, the XTEN further comprises one or more additional barcode segments, wherein each of the additional one or more barcode segments is different from all other peptide segments that can be released from the polypeptide after complete digestion of the polypeptide by the protease The difference lies in the sequence and molecular weight. In certain embodiments, the release segment ( RS ) comprises at least 90%, 91%, 92%, 93%, 94%, 95% of the sequence identified herein by SEQ ID NO: 7001-7626 Amino acid sequences having %, 96%, 97%, 98%, 99% or 100% sequence identity. In certain embodiments, the protease cleaves on the C-terminal side of a glutamic acid residue not followed by a proline. In certain embodiments, the protease is Glu-C protease.

In certain embodiments, the polypeptide is expressed as a fusion protein, wherein the fusion protein in the uncleaved state has AF1-AF2-RS-XTEN, AF2-AF1-RS-XTEN, XTEN-RS- Structural arrangement of AF1-AF2 or XTEN-RS-AF2-AF1. In certain embodiments, the release segment ( RS ) is fused to the bispecific antibody construct ( BsAb ) via a spacer. In certain embodiments, the spacer comprises at least 4 types of amino acids, such as glycine (G), alanine (A), serine (S), threonine (T), glutamic acid (E) or proline (P). In certain embodiments, the spacer comprises an amino acid sequence having at least 80%, 90%, or 100% sequence identity to the sequences set forth in Table C. In certain embodiments, the CDR-H1 and the CDR-H2 of the first antigen-binding fragment ( AF1 ) comprise the amino acid sequences of SEQ ID NO: 8 and 9 , respectively.

In certain embodiments, the CDR-L1 of the AF1 comprises the amino acid sequence of SEQ ID NO: 1 or 2 ; the CDR-L2 of the AF1 comprises the amino acid sequence of SEQ ID NO: 4 or 5 ; and The CDR-L3 of the AF1 comprises the amino acid sequence of SEQ ID NO:6 . In certain embodiments, the CDR-L1 of the AF1 comprises the amino acid sequence of SEQ ID NO:1 ; the CDR-L2 of the AF1 comprises the amino acid sequence of SEQ ID NO:4 or 5 ; and the AF1 The CDR-L3 comprises the amino acid sequence of SEQ ID NO:6 . In certain embodiments, the CDR-L1 of the AF1 comprises the amino acid sequence of SEQ ID NO:2 ; the CDR-L2 of the AF1 comprises the amino acid sequence of SEQ ID NO:4 or 5 ; and the AF1 The CDR-L3 comprises the amino acid sequence of SEQ ID NO:6 . In certain embodiments, the CDR-L1 of the AF1 comprises the amino acid sequence of SEQ ID NO:1 ; the CDR-L2 of the AF1 comprises the amino acid sequence of SEQ ID NO:4 ; and the AF1 of the CDR-L3 comprises the amino acid sequence of SEQ ID NO:6 . In certain embodiments, the CDR-L1 of the AF1 comprises the amino acid sequence of SEQ ID NO:2 ; the CDR-L2 of the AF1 comprises the amino acid sequence of SEQ ID NO:5 ; and the AF1 of CDR-L3 comprises the amino acid sequence of SEQ ID NO:6 . In certain embodiments, the first antigen-binding fragment ( AF1 ) comprises four chain variable domain framework regions 1 (FR-H1), 2 (FR-H2), 3 (FR-H3) and 4 (FR- H4), the framework regions respectively exhibit at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93% of the amino acid sequences of SEQ ID NO: 60 , 64 , 65 and 67 %, 94%, 95%, 96%, 97%, 98% or 99% sequence identity or is identical to the amino acid sequence. In certain embodiments, the first antigen-binding fragment ( AF1 ) comprises four chain variable domain framework regions 1 (FR-H1), 2 (FR-H2), 3 (FR-H3) and 4 (FR- H4), the framework regions respectively exhibit at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93% of the amino acid sequences of SEQ ID NO: 61 , 64 , 65 and 67 %, 94%, 95%, 96%, 97%, 98% or 99% sequence identity or is identical to the amino acid sequence. In certain embodiments, the first antigen-binding fragment further comprises four light chain variable domain framework regions (FR-L): FR-L1, FR-L2, FR-L3, and FR-L4, the framework regions Each exhibits at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95% of the amino acid sequence of SEQ ID NO: 51 , 52 , 53 and 59 , respectively , 96%, 97%, 98% or 99% sequence identity or identical to such amino acid sequences. In certain embodiments, the first antigen-binding fragment further comprises four light chain variable domain framework regions (FR-L): FR-L1, FR-L2, FR-L3, and FR-L4, the framework regions Each exhibits at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95% of the amino acid sequence of SEQ ID NO: 51 , 52 , 54 , and 59 , respectively , 96%, 97%, 98% or 99% sequence identity or identical to such amino acid sequences.

In certain embodiments, the first antigen-binding fragment further comprises four light chain variable domain framework regions (FR-L): FR-L1, FR-L2, FR-L3, and FR-L4, the framework regions Each exhibits at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95% of the amino acid sequence of SEQ ID NO: 51 , 52 , 55 and 59 , respectively , 96%, 97%, 98% or 99% sequence identity or identical to such amino acid sequences. In certain embodiments, the first antigen-binding fragment further comprises four light chain variable domain framework regions (FR-L): FR-L1, FR-L2, FR-L3, and FR-L4, the framework regions Each exhibits at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95% of the amino acid sequence of SEQ ID NO: 51 , 52 , 56 and 59 , respectively , 96%, 97%, 98% or 99% sequence identity or identical to such amino acid sequences. In certain embodiments, the first antigen-binding fragment ( AF1 ) further comprises light chain framework regions 1 (FR-L1), 2 (FR-L2), 3 (FR-L3) and 4 (FR-L4) and Heavy chain framework regions 1 (FR-H1), 2 (FR-H2), 3 (FR-H3) and 4 (FR-H4), wherein: the FR-L1 comprises the amino acid sequence of SEQ ID NO:51 ; The FR-L2 comprises the amino acid sequence of SEQ ID NO:52 ; the FR-L3 comprises the amino acid sequence of SEQ ID NO:53 , 54 , 55 or 56 ; the FR-L4 comprises the amine of SEQ ID NO:59 amino acid sequence; the FR-H1 comprises the amino acid sequence of SEQ ID NO:60 or 61 ; the FR-H2 comprises the amino acid sequence of SEQ ID NO:64 ; the FR-H3 comprises the amine of SEQ ID NO:65 amino acid sequence; and the FR-H4 comprises the amino acid sequence of SEQ ID NO:67 .

In certain embodiments, the first antigen-binding fragment ( AF1 ) further comprises light chain framework regions 1 (FR-L1), 2 (FR-L2), 3 (FR-L3) and 4 (FR-L4) and Heavy chain framework regions 1 (FR-H1), 2 (FR-H2), 3 (FR-H3) and 4 (FR-H4), wherein: the FR-L1 comprises the amino acid sequence of SEQ ID NO:51 ; The FR-L2 comprises the amino acid sequence of SEQ ID NO:52 ; the FR-L3 comprises the amino acid sequence of SEQ ID NO:53 ; the FR-L4 comprises the amino acid sequence of SEQ ID NO:59 ; the FR -H1 comprises the amino acid sequence of SEQ ID NO:60 ; the FR-H2 comprises the amino acid sequence of SEQ ID NO:64 ; the FR-H3 comprises the amino acid sequence of SEQ ID NO:65 ; and the FR- H4 comprises the amino acid sequence of SEQ ID NO:67 .

In certain embodiments, the first antigen-binding fragment ( AF1 ) further comprises light chain framework regions 1 (FR-L1), 2 (FR-L2), 3 (FR-L3) and 4 (FR-L4) and Heavy chain framework regions 1 (FR-H1), 2 (FR-H2), 3 (FR-H3) and 4 (FR-H4), wherein: the FR-L1 comprises the amino acid sequence of SEQ ID NO:51 ; The FR-L2 comprises the amino acid sequence of SEQ ID NO:52 ; the FR-L3 comprises the amino acid sequence of SEQ ID NO:54 ; the FR-L4 comprises the amino acid sequence of SEQ ID NO:59 ; the FR -H1 comprises the amino acid sequence of SEQ ID NO:61 ; the FR-H2 comprises the amino acid sequence of SEQ ID NO:64 ; the FR-H3 comprises the amino acid sequence of SEQ ID NO:65 ; and the FR- H4 comprises the amino acid sequence of SEQ ID NO:67 .

In certain embodiments, the first antigen-binding fragment ( AF1 ) further comprises light chain framework regions 1 (FR-L1), 2 (FR-L2), 3 (FR-L3) and 4 (FR-L4) and Heavy chain framework regions 1 (FR-H1), 2 (FR-H2), 3 (FR-H3) and 4 (FR-H4), wherein: the FR-L1 comprises the amino acid sequence of SEQ ID NO:51 ; The FR-L2 comprises the amino acid sequence of SEQ ID NO:52 ; the FR-L3 comprises the amino acid sequence of SEQ ID NO:55 ; the FR-L4 comprises the amino acid sequence of SEQ ID NO:59 ; the FR -H1 comprises the amino acid sequence of SEQ ID NO:61 ; the FR-H2 comprises the amino acid sequence of SEQ ID NO:64 ; the FR-H3 comprises the amino acid sequence of SEQ ID NO:65 ; and the FR- H4 comprises the amino acid sequence of SEQ ID NO:67 .

In certain embodiments, the first antigen-binding fragment ( AF1 ) further comprises light chain framework regions 1 (FR-L1), 2 (FR-L2), 3 (FR-L3) and 4 (FR-L4) and Heavy chain framework regions 1 (FR-H1), 2 (FR-H2), 3 (FR-H3) and 4 (FR-H4), wherein: the FR-L1 comprises the amino acid sequence of SEQ ID NO:51 ; The FR-L2 comprises the amino acid sequence of SEQ ID NO:52 ; the FR-L3 comprises the amino acid sequence of SEQ ID NO:56 ; the FR-L4 comprises the amino acid sequence of SEQ ID NO:59 ; the FR -H1 comprises the amino acid sequence of SEQ ID NO:61 ; the FR-H2 comprises the amino acid sequence of SEQ ID NO:64 ; the FR-H3 comprises the amino acid sequence of SEQ ID NO:65 ; and the FR- H4 comprises the amino acid sequence of SEQ ID NO:67 .

In certain embodiments, the first antigen-binding fragment ( AF1 ) exhibits higher thermal stability than the anti-CD3-binding fragment having the sequence set forth in SEQ ID NO: 206 , as determined in an in vitro assay by Demonstration of: a higher melting temperature (Tm) of the first antigen-binding fragment relative to the melting temperature ( _Tm ) of the anti-CD3-binding fragment; or upon incorporation of the first antigen-binding fragment into a test bispecific antigen A higher Tm of the test bispecific antigen-binding construct relative to the _Tm of the control bispecific antigen-binding construct after binding into the construct, wherein the test bispecific antigen-binding construct comprises the first An antigen-binding fragment and a reference antigen-binding fragment that binds to an antigen other than CD3; and wherein the control bispecific antigen-binding construct consists of the anti-CD3-binding fragment and the reference antigen-binding fragment, the anti-CD3-binding fragment consisting of the SEQ ID NO : Sequence composition of ID NO:206 . In certain embodiments, the _Tm of the first antigen-binding fragment is at least 2°C higher, or at least 3°C higher, than the _Tm of the anti-CD3-binding fragment consisting of the sequence of SEQ ID NO: 206 , or At least 4°C higher, or at least 5°C higher. In certain embodiments, the first antigen-binding fragment ( AF1 ) comprises a heavy chain variable region (VH _I ), wherein the VH _I comprises at least 90% of the amino acid sequence of SEQ ID NO: 102 or 105 , 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence identity or an amino acid sequence identical to the amino acid sequence. In certain embodiments, the first antigen-binding fragment ( AF1 ) comprises a light chain variable region (VL _I ), wherein the VL _I comprises any one of SEQ ID NO: 101 , 103 , 104 , 106 or 107 An amino acid sequence having at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence identity or an amino group identical to the amino acid sequence acid sequence. In certain embodiments, the VH _I and the VL _I are linked by a linker comprising at least 90%, 91%, 92%, 93%, 94%, An amino acid sequence with 95%, 96%, 97%, 98%, 99% or 100% sequence identity. In certain embodiments, the first antigen-binding fragment ( AF1 ) comprises at least 95%, 96%, 97%, 98%, 99% of the amino acid sequence of any one of SEQ ID NO: 201-205 Sequence identity or an amino acid sequence identical to the amino acid sequence. In certain embodiments, the first antigen-binding fragment ( AF1 ) specifically binds human or cynomolgus monkey (cyno) CD3. In certain embodiments, the first antigen-binding fragment ( AF1 ) specifically binds human CD3. In certain embodiments, the first antigen-binding fragment ( AF1 ) binds a subunit of the CD3 complex that is a CD3ε, CD3δ, CD3γ or CD3ζ unit of CD3. In certain embodiments, the first antigen-binding fragment ( AF1 ) binds the CD3ε fragment of CD3. In certain embodiments, the first antigen-binding fragment ( AF1 ) exhibits an isoelectric point (pi) of less than or equal to 6.6. In certain embodiments, the first antigen-binding fragment ( AF1 ) exhibits an isoelectric point (pi) between 6.0 and 6.6, inclusive.

In certain embodiments, the first antigen-binding fragment ( AF1 ) exhibits an isoelectric point (pI) that is at least 0.1, 0.2, 0.3, 0.4 lower than that of a reference antigen-binding fragment having the sequence set forth in SEQ ID NO: 206 , 0.5, 0.6, 0.7, 0.8, 0.9, or 1.0 pH units of pi. In certain embodiments, the first antigen-binding fragment ( AF1 ) specifically binds human or cyno CD3 with a dissociation constant ( _Kd ) constant of between about 10 nM and about 400 nM, such as in a protein comprising As determined in an in vitro antigen binding assay of human or cyno CD3 antigen. In certain embodiments, the first antigen-binding fragment ( AF1 ) is less than about 10 nM, or less than about 50 nM, or less than about 100 nM, or less than about 150 nM, or less than about 200 nM, or less than about 250 nM A dissociation constant ( _Kd ) of nM, or less than about 300 nM, or less than about 350 nM, or less than about 400 nM, specifically binds human or cyno CD3 as determined in an in vitro antigen binding assay. In certain embodiments, the first antigen-binding fragment ( AF1 ) exhibits a binding affinity for CD3 that is at least 2-fold, 3-fold weaker relative to the antigen-binding fragment consisting of the amino acid sequence of SEQ ID NO: 206 , 4-fold, 5-fold, 6-fold, 7-fold, 8-fold, 9-fold, or at least 10-fold greater binding affinity for CD3 as determined by the respective dissociation constant ( _Kd ) in an in vitro antigen binding assay.

In certain embodiments, the first antigen-binding fragment ( AF1 ) is a chimeric or humanized antigen-binding fragment. In certain embodiments, the first antigen-binding fragment ( AF1 ) is Fv, Fab, Fab', Fab'-SH, linear antibody or single chain variable fragment (scFv). In certain embodiments, the second antigen-binding fragment ( AF2 ) is Fv, Fab, Fab', Fab'-SH, linear antibody, single domain antibody or single chain variable fragment (scFv). In certain embodiments, the first antigen-binding fragment and the second antigen-binding fragment are configured as (Fab') ₂ or single-chain diabodies. In certain embodiments, the second antigen-binding fragment ( AF2 ) comprises: a heavy chain variable region (VH _II ) comprising the amino acid sequence identified herein by SEQ ID NO: 778-783 ; and a light chain variable region (VL _II ), comprising the amino acid sequence identified herein by SEQ ID NO: 878-883 . In certain embodiments, the VH _II and the VL _II are connected by a linker comprising at least 90%, 91%, 92%, 93%, 94%, An amino acid sequence with 95%, 96%, 97%, 98%, 99% or 100% sequence identity. In certain embodiments, the first antigen-binding fragment and the second antigen-binding fragment are fused together via a peptide linker. In certain embodiments, the peptide linker comprises 2 or 3 types of amino acids, the amino acids being glycine, serine or proline. In certain embodiments, the peptide linker comprises at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% of the sequence set forth in Table B Amino acid sequences with % or 100% sequence identity.

In certain embodiments, the XTEN is a first expanded recombinant polypeptide ( XTEN1 ); formed from a plurality of non-overlapping sequence motifs, the plurality of non-overlapping sequence motifs comprising a first plurality of non-overlapping sequence motifs; the BAR is the first barcode fragment ( BAR1 ); and the RS is the first release segment ( RS1 ); and the polypeptide further comprises: (d) a second expanded recombinant polypeptide ( XTEN2 ), which comprises a second barcode segment ( BAR2 ) released from the polypeptide; and (e) a second release segment ( RS2 ), which is located between the second XTEN ( XTEN2 ) and the bispecific antibody construct ( BsAb ), wherein The XTEN2 is characterized in that: (i) it comprises at least 100 or at least 150 amino acids; (ii) at least 90% of its amino acid residues are glycine (G), alanine (A), silk amino acid (S), threonine (T), glutamic acid (E) or proline (P); and (iii) which comprise at least 4 different types of amino acids which are G , A, S, T, E, or P; wherein the second barcode fragment ( BAR2 ) differs in sequence and molecular weight from all other peptide fragments that can be released from the polypeptide after the protease has completely digested the polypeptide; and wherein The second barcode fragment ( BAR2 ) does not include the N-terminal amino acid or the C-terminal amino acid of the polypeptide. In certain embodiments, the XTEN1 is located at the N-terminus of the bispecific antibody construct, and the XTEN2 is located at the C-terminus of the bispecific antibody construct. In certain embodiments, the XTEN1 is located at the C-terminus of the bispecific antibody construct, and the XTEN2 is located at the N-terminus of the bispecific antibody construct.

In certain embodiments, the XTEN2 is formed from a second plurality of non-overlapping sequence motifs, each of the second plurality of non-overlapping sequence motifs is 9 to 14 amino acids in length, wherein the second plurality of non-overlapping Overlapping sequence motifs comprise: (1) a second set of non-overlapping sequence motifs that are repeated at least twice in the second XTEN; and (2) a non-overlapping sequence motif that only occurs within the second XTEN once; and wherein the second barcode segment ( BAR2 ) includes at least a portion of the non-overlapping sequence motif that occurs only once within the second XTEN. In certain embodiments, the second set of non-overlapping sequence motifs are each independently identified herein by SEQ ID NO: 179-200 and 1715-1722 . In certain embodiments, the second set of non-overlapping sequence motifs are each independently identified herein by SEQ ID NO: 186-189 . In certain embodiments, the second set of non-overlapping sequence motifs comprises at least two, at least three, or all four of the sequence motifs SEQ ID NO: 186-189 . In certain embodiments, the XTEN2 comprises 100 to 3,000, 150 to 3,000, 100 to 1,000, or 150 to 1,000 amino acid residues in length. In certain embodiments, the XTEN2 comprises at least 200, at least 250, at least 300, at least 350, at least 400, at least 450, or at least 500 amino acid residues in length.

In certain embodiments, at least 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% of the amino acid residues of the XTEN2 are glycine (G), alanine (A), serine (S), threonine (T), glutamic acid (E) or proline (P). In certain embodiments, the XTEN2 has at least 90%, at least 92%, at least 95%, at least 98%, at least 99%, or 100% sequence identity to the sequences set forth in Table 3a . In certain embodiments, the second barcode segment ( BAR2 ) does not include a glutamic acid immediately adjacent to another glutamic acid (if present) in the XTEN2. In certain embodiments, the second barcode segment ( BAR2 ) has glutamic acid at its C-terminus. In certain embodiments, the second barcode segment ( BAR2 ) has an N-terminal amino acid immediately following the glutamic acid residue. In certain embodiments, the second barcode segment ( BAR2 ) is located at a distance from the N-terminus of the polypeptide or the C-terminus of the polypeptide, wherein the distance is 10 to 150 amino acids or 10 to 125 amino acids amino acid length. In certain embodiments, the second barcode segment ( BAR2 ) is characterized in that: (i) it does not include a glutamic acid immediately adjacent to another glutamic acid (if present) in the XTEN2; (ii) it contains It has glutamic acid at the C-terminus; (iii) it has the N-terminal amino acid immediately following the glutamic acid residue; and (iv) it is at a distance from the N-terminus of the polypeptide or the C-terminus of the polypeptide Positioning, wherein the distance is 10 to 150 amino acids or 10 to 125 amino acids in length.

In certain embodiments, the glutamic acid residue preceding the N-terminal amino acid of the BAR2 is not immediately adjacent to another glutamic acid residue. In certain embodiments, the second barcode segment ( BAR2 ) does not include a second glutamic acid residue at a position other than the C-terminus of the second barcode segment ( BAR2 ), unless the second glutamic acid is followed by followed by proline. In certain embodiments, the XTEN2 is located at the N-terminus of the bispecific antibody construct ( BsAb ), and wherein the second barcode fragment ( BAR2 ) is located at 200, 150, 100 or 200 of the N-terminus of the polypeptide within 50 amino acids. In certain embodiments, the XTEN2 is located at the N-terminus of the bispecific antibody construct ( BsAb ), and wherein the second barcode segment ( BAR2 ) is located between 10 and 200, Between 30 and 200, between 40 and 150, or between 50 and 100 amino acid positions. In certain embodiments, the XTEN2 is located at the C-terminus of the bispecific antibody construct ( BsAb ), and wherein the second barcode fragment ( BAR2 ) is located at 200, 150, 100 or 200 of the C-terminus of the polypeptide within 50 amino acids. In certain embodiments, the XTEN2 is located at the C-terminus of the bispecific antibody construct ( BsAb ), and the second barcode segment ( BAR2 ) is located between 10 and 200, 30, Between 1 and 200, between 40 and 150, or between 50 and 100 amino acid positions.

In certain embodiments, the second barcode segment ( BAR2 ) is at least 4 amino acids in length. In certain embodiments, the length of the second barcode segment ( BAR2 ) is between 4 and 20, between 5 and 15, between 6 and 12 or between 7 and 10 amino acids between them. In certain embodiments, the second barcode segment ( BAR2 ) comprises the amino acid sequence as set forth in Table 2 . In certain embodiments, the length of the XTEN2 is defined by a proximal end and a distal end, wherein (1) the proximal end of the XTEN2 is positioned closer to the bispecific antibody construct ( BsAb ) than the distal end , and wherein (2) the second barcode segment ( BAR2 ) is located between 5% and 50%, between 7% and 40%, or 10% of the length of the XTEN2 as measured from the distal end of the XTEN2 % and 30% within the region of the XTEN2 . In certain embodiments, the XTEN2 further comprises one or more additional barcode segments, wherein each of the additional one or more barcode segments of the XTEN2 is associated with all other peptides that can be released from the polypeptide after complete digestion of the polypeptide by the protease Fragments differ in sequence and molecular weight. In some embodiments, the first release segment ( RS1 ) is identical in sequence to the second release segment ( RS2 ). In some embodiments, the sequence of the first release segment ( RS1 ) is not consistent with that of the second release segment ( RS2 ). In certain embodiments, the second release segment ( RS2 ) comprises at least 90%, 91%, 92%, 93%, 94% of the sequence identified herein by SEQ ID NO:7001-7626 , 95%, 96%, 97%, 98%, 99% or 100% amino acid sequence identity. In certain embodiments, the first release segment ( RS1 ) and the second release segment ( RS2 ) are each configured for one, two or three cleavage sites within each release segment sequence by Substrate for cleavage by various proteases.

In certain embodiments, the polypeptide is expressed as a fusion protein, wherein the fusion protein in the uncleaved state has from the N-terminus to the C-terminus defined herein by XTEN1-RS1-AF1-AF2-RS2-XTEN2, XTEN1-RS1 -AF2-AF1-RS2-XTEN2, XTEN2-RS2-AF1-AF2-RS1-XTEN1, XTEN2-RS2-AF2-AF1-RS1-XTEN1, XTEN1-RS1-bifunctional antibody-RS2-XTEN2 or XTEN2-RS2-bifunctional Functional antibody-RS1-XTEN1 marked structural arrangement, wherein the bifunctional antibody comprises the light chain variable region (VL _I ) of the AF1, the heavy chain variable region (VH I ) of the AF1, and the light chain variable region (VH _I ) of the AF2. variable region (VL _II ) and the heavy chain variable region (VH _II ) of the AF2. In certain embodiments, the spacer of the first release segment ( RS1 ) is a first spacer, and wherein the second release segment ( RS2 ) is connected to the bispecific antibody via a second spacer Construct ( BsAb ) fusion. In some embodiments, the second spacer comprises at least 4 types of amino acids, these amino acids are glycine (G), alanine (A), serine (S), threonine acid (T), glutamic acid (E) or proline (P). In certain embodiments, the second spacer comprises at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, Amino acid sequences with 99% or 100% sequence identity.

In certain embodiments, the XTEN1 comprises at least about 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% of the sequence set forth in Table 3a or the amino acid sequence of 100% sequence identity; the BsAb comprises: the AF1 , which comprises light chain complementarity determining regions 1 (CDR-L1), 2 (CDR-L2) and 3 (CDR-L3) and heavy chain complementarity Determining regions 1 (CDR-H1), 2 (CDR-H2) and 3 (CDR-H3), wherein the CDR-H1, the CDR-H2 and the CDR-H3 comprise SEQ ID NO: 8 , 9 and 10 , respectively Amino acid sequence; and the AF2 , which comprises the light chain variable region (VL _II ) identified herein by SEQ ID NO: 778-783 and identified herein by SEQ ID NO: 878-883 The heavy chain variable region (VH _II ); the RS1 comprises at least 90%, 91%, 92%, 93%, 94%, 95% of the sequence identified herein by SEQ ID NO: 7001-7626 , 96%, 97%, 98%, 99% or 100% sequence identity of amino acid sequences; the XTEN2 comprises at least about 90%, 91%, 92%, 93%, Amino acid sequences with 94%, 95%, 96%, 97%, 98%, 99% or 100% sequence identity; and the RS2 comprises sequences identified herein by SEQ ID NO: 7001-7626 An amino acid sequence having at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity, wherein the polypeptide is from the N-terminus to The C-terminus has an XTEN1-RS1-AF2-AF1-RS2-XTEN2, XTEN1-RS1-AF1-AF2-RS2-XTEN2, XTEN2-RS2-AF2-AF1-RS1-XTEN1 or XTEN2-RS2-AF1 identified herein - Structural arrangement of AF2-RS1-XTEN1.

In certain embodiments, the polypeptide has a terminal half-life that is at least two-fold longer than that of a bispecific antibody construct that is not linked to any XTEN. In certain embodiments, the polypeptide has low immunogenicity compared to a bispecific antibody construct not linked to any XTEN, as measured by selective binding to the XTEN following administration of a comparable dose to an individual. IgG antibody production of bispecific antibody constructs was determined. In certain embodiments, the polypeptide exhibits an apparent molecular weight factor of greater than about 3, greater than about 4, greater than about 5, or greater than about 6 under physiological conditions. In certain embodiments, the polypeptide comprises at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, Amino acid sequences with 98%, 99% or 100% sequence identity.

In certain embodiments, pharmaceutical compositions comprise the above polypeptides and one or more pharmaceutically suitable excipients. In certain embodiments, the pharmaceutical compositions are formulated for administration to humans or animals by any clinically appropriate route and formulation. In certain embodiments, the pharmaceutical composition is in liquid form or frozen. In certain embodiments, the pharmaceutical composition is in a prefilled syringe for single injection. In certain embodiments, the pharmaceutical composition is formulated as a lyophilized powder to be reconstituted prior to administration.

In certain embodiments, the composition is in pharmaceutical combination with at least one additional therapeutic agent selected from the group consisting of antibodies, antibody fragments, antibody conjugates, cytotoxic agents, toxins, radionuclides, immunomodulators, photosensitizing Sexual therapeutic agents, radiosensitizers, hormones, anti-angiogenic agents and combinations thereof.

The additional therapeutic agent can be a PD-1/PD-L1(2) inhibitor, wherein the PD-1/PD-L1(2) inhibitor is an anti-PD-1 antibody or an anti-PD-L1 antibody or an anti-PD-L2 antibody.

In certain embodiments, the PD-1/PD-L1(2) inhibitor is an anti-PD-1 antibody selected from the group comprising: nivolumab (Opdivo, BMS- 936558, MDX1106), pembrolizumab (Keytruda, MK-3475, lambrolizumab), pidilizumab (CT-011), PDR- 001, JS001, STI-A1110, AMP-224 and AMP-514 (MEDI0680).

In one embodiment, the PD-1/PD-L1(2) inhibitor may be an anti-PD-L1 antibody selected from the group comprising: atezolizumab (Tecentriq, MPDL3280A ), durvalumab (MEDI4736), avelumab (avelumab) (MSB0010718C), BMS-936559 (MDX1105) and LY3300054. In another embodiment, the PD1/PD-L1(2) inhibitor is an anti-PD-L2 antibody.

In certain embodiments, the combination is a combination package containing components that are independent of each other. In certain embodiments, the components are administered simultaneously or sequentially in separate dosage forms for the treatment of the same disease.

In certain embodiments, the polypeptides described herein are part of a pharmaceutical combination useful as an agent for the treatment of a hyperproliferative disorder. The hyperproliferative disorder is selected from the group consisting of breast cancer, respiratory tract cancer, brain cancer, reproductive organ cancer, digestive tract cancer, urinary tract cancer, eye cancer, liver cancer, skin cancer, head and neck cancer, thyroid cancer, parathyroid cancer and distant side transfer.

In certain embodiments, polypeptides as described herein are used in the manufacture of a medicament for treating a disease in a subject. In certain embodiments, the disease is cancer.

In certain embodiments, methods of treating a disease in a subject comprise administering to the subject in need thereof one or more therapeutically effective doses of a pharmaceutical composition or combination.

In one embodiment, the disease is cancer. In certain embodiments, the cancer is selected from the group consisting of glioblastoma, melanoma, cholangiocarcinoma, small cell lung cancer, colorectal cancer, prostate cancer, vaginal cancer, angiosarcoma, non-small cell lung cancer, appendix carcinoma, squamous cell carcinoma, salivary duct carcinoma, adenoid cystic carcinoma, small bowel carcinoma and gallbladder carcinoma.

Provided herein is a method of treating a disease in a subject comprising administering to the subject in need thereof one or more therapeutically effective doses of the above pharmaceutical composition. In certain embodiments, pharmaceutical compositions are administered to a subject in one or more therapeutically effective dosages administered during a therapeutically effective course of treatment. In certain embodiments, dosages are administered to humans or animals by any clinically appropriate route and formulation. In certain embodiments, the individual is a mouse, rat, monkey or human.

Also provided herein is a nucleic acid comprising a polynucleotide sequence encoding a polypeptide as described herein, or the reverse complement of the polynucleotide sequence. Further provided herein is an expression vector comprising the polynucleotide sequence as described herein and a recombination regulatory sequence operably linked to the polynucleotide sequence. Provided herein is a host cell comprising the expression vector. In certain embodiments, the host cell is a prokaryotic cell. In certain embodiments, the host cell is Escherichia coli (E. coli) . In certain embodiments, the host cell is a mammalian cell.

Additional aspects and advantages of the present invention will become apparent to those skilled in the art from the following description, in which only illustrative embodiments of the invention are shown and described. As will be realized, the invention is capable of other and different embodiments, and its several details are capable of modifications in various obvious respects, all without departing from the invention. Accordingly, the drawings and embodiments are to be regarded as illustrative in nature and not restrictive.

Sequence listing statement :

The computer readable form of the Sequence Listing is filed by electronic filing with this application and is hereby incorporated by reference in its entirety. The sequence listing is contained in a file created on June 14, 2021 with the file name "789-601_20-1832-WO_ST25_FINAL.txt" and a size of 1502 kb. reference statement

This application asserts U.S. Provisional Patent Application No. 63/044,301, filed on June 25, 2020, entitled "BARCODED BISPECIFIC COMPOSITIONS AND METHODS FOR MAKING AND USING THE SAME," and filed on September 11, 2020, entitled " BARCODED BISPECIFIC COMPOSITIONS AND METHODS FOR MAKING AND USING THE SAME", U.S. Provisional Patent Application No. 63/077,503, filed on November 2, 2020 Patent Application No. 63/108,783, U.S. Provisional Patent Application No. 63/166,857, filed March 26, 2021, entitled "HER2 TARGETED BISPECIFIC COMPOSITIONS AND METHODS FOR MAKING AND USING THE SAME" and June 3, 2021 Priority to U.S. Provisional Patent Application No. 63/196,408, entitled "HER2 TARGETED BISPECIFIC COMPOSITIONS AND METHODS FOR MAKING AND USING THE SAME," filed on 11 December 2011, all of which are incorporated herein in their entirety. incorporated by reference

All publications, patents, and patent applications mentioned in this specification are herein incorporated by reference to the same extent as if each individual publication, patent, or patent application was specifically and individually indicated to be incorporated by reference. Incorporated into general.

There is a significant unmet need for cancer therapeutics. Although TCE has been shown to be effective in inducing remission in certain cancers, it has not yielded a broad therapeutic agent due to its extreme potency in healthy tissue and on-target, off-tumor toxicity. By way of explanation, TCE forms a bridge between T cells and tumor cells and activates T cell-mediated tumor cells and further triggers a cytokine amplification cascade, thereby promoting further killing and possibly providing long-term immunity. TCE activates T cells to release cytolytic perforins/granzymes in a manner independent of antigen-MHC recognition. This produces a dual response: direct tumor cell death and tumor-killing amplification by eliciting a potent cytokine response from tumor cells. Direct tumor cell death results in the release of tumor antigens. Cytokinin responses include, inter alia: increased interferon-γ responses, which stimulate CD8 T cell activity and stimulate antigen presentation by APCs; increased IL2 responses, which lead to increased proliferation of activated T cells; and increased CXCL9 and CXCL10 responses, which increase T cell recruitment. Tumor antigen release and interleukin response priming together lead to activation of endogenous T cell responses, which may allow epitope spreading to induce long-term immunity.

The toxic challenge of TCE arises from the fact that most tumor targets are also expressed to some extent in healthy tissues, and normal cells can also produce cytokine responses, leading to the cytokine release syndrome (CRS). These two robust responses of healthy tissue to TCE-activated T cells produce an overall lack of therapeutic index for these agents.

The present invention overcomes the limitations of existing TCEs by providing conditionally activated TCEs, XPATs, or XTENylated protease - activated bispecific T cell engagers targeting HER2 (referred to herein as HER2-XPAT and exemplified as AMX818) shortcoming. More specifically, the XPATs of the present invention take advantage of the dysregulated protease activity present in tumors relative to healthy tissue, enabling an expansion of the therapeutic index. The XPAT core consists of 2 single chain antibody fragments (scFv) targeting CD3 and a tumor target (in an exemplary embodiment, the tumor target is HER2). Two unstructured polypeptide masks (XTEN) are attached to the core to sterically reduce tumor target and/or target engagement of CD3 and prolong protein half-life. The properties of XTEN polymers also minimize the potential for immunogenicity because they do not have a stable tertiary structure that would be detrimental to antibody binding, and there are no hydrophobic, aromatic and Positively charged residues reduce the potential of T cell epitopes. In humans, minimal immunogenicity of XTEN polymers was observed in >200 patients treated with XTEN-containing drugs in the case of human growth hormone and half-life-extended forms of Factor VIII. Protease cleavage sites at bases masked by XTEN enable proteolytic activation of XPAT in the tumor microenvironment, abruptly releasing small, highly efficient TCEs that can then redirect cytotoxic T cells to kill tumor cells expressing their targets. In healthy tissue, where protease activity is tightly regulated, XPAT should remain largely inactive as the intact prodrug, thus extending the therapeutic index compared to unmasked TCE.

In addition to local activation, the short half-life of the unmasked PAT form should further broaden the therapeutic index while providing the potency of T cell immunity to improve solid tumor eradication. The release site used in XPAT can be cleaved in a broad array of tumors by proteases collectively involved in each hallmark of cancer (growth; survival and death; angiogenesis; invasion and metastasis; inflammation; and immune evasion). Thus, the TCE activity of XPAT is localized to tumors by employing enhanced protease activity that is upregulated in all stages of cancer and tumor development, but tightly regulated in healthy tissues.

The components of AMX-818, an exemplary HER2-XPAT, have been optimized to achieve the desired balance of providing adequate protection in healthy tissue while maintaining the necessary potency in tumors in a broad range of cancers. To reduce the potential of the prodrug to activate T cells, in addition to the longer XTEN polymer mask (576 amino acid mask versus 256 amino acids on the HER2 side), a lower binding affinity was selected for a - CD3 domain. To ensure sufficient activation of AMX-818 in tumors, the protease release site at the XTEN masked base was engineered to contain at least 8 different proteins in 3 different classes that have been reported to be overrepresented or dysregulated in cancer Cleavage by proteases; these include several matrix metalloproteinases (MMPs), interstitial proteases, uPA and cysteine proteases, pod proteins. As a safety checkpoint, AMX-818 co-engages both CD3 and HER2, which are required for T cell activation. T cell activation should not occur if AMX-818 is unmasked in inflamed tissue where HER2 expression is absent or if AMX-818 encounters HER2 expressed in healthy tissue where proteases are tightly controlled. This AND-gate feature is expected to provide preferential activation in tumors where there is both high protease activity and high HER2 expression.

Thus, the presence of XTEN on XPAT produces an agent with long half-life, weak target engagement and negligible T cell activation. Once XTEN is removed by the action of proteases in the tumor microenvironment, this preferential XPAT activation produces an activated drug (PAT, without XTEN) with short half-life, optimal target engagement, and efficient T cell activation, thereby producing Potent activated drug with enhanced therapeutic index. The HER2-XPAT of the present invention is able to improve the toxicity profile of T cell engagers while maintaining their potency against solid tumors, thus enabling a significant increase in therapeutic index and expanded targeting prospects for this potent modality. Summary of data generated by AMX -818 as an exemplary HER2-XPAT

The target binding and in vitro bioactivity of AMX-818 have been characterized in multiple studies. Equilibrium binding analysis using surface plasmon resonance demonstrated highly comparable affinity for AMX-818 and its metabolites between human and cynomolgus HER2 and CD3, supporting cynomolgus as a species for toxicity and PK studies. Proteolytically activated AMX-818(PAT) binds to human and cynomolgus HER2 with 2.4 nM and 2.0 nM affinity, respectively, and binds to human and cynomolgus CD3 with 26.3 nM and 21.5 nM affinity, respectively. For both species, AMX-818 occlusion reduced their affinity for HER2 by 10-fold and for CD3 by approximately 6-fold. AMX-818 binds to human and cynomolgus HER2 with an affinity of 24.9 nM and 20.1 nM, respectively, while the human and cynomolgus CD3 affinities are 160 nM and 140.3 nM, respectively.

The activity of TCEs is determined by their ability to activate T cells by potently stimulating the T cell receptor (TCR). The extreme potency of TCEs derives from the minimal requirement for as few as 3 TCRs to become stimulated and coalesce to form an immune synapse between T cells and target cells to elicit cytotoxicity. Although T cell engagers are primarily known to induce cytotoxicity, their potency has also been implicated in enhancing and amplifying cytokine-driven effects downstream of T cell activation of antitumor immune responses. Activation of T cells by AMX-818, its prototype AMX-818-P1, and its proteolytic metabolites utilizes Jurkat NFAT in the presence of HER2-highly expressing tumor cells BT-474 (breast) and SKOV-3 (ovary) Reporter cells and primary human PBMC were characterized in vitro. Upregulation of the surface activation marker CD69 and the inhibitory receptor PD-1 in human T cells was also assessed by flow cytometry. As an indirect measure of T cell activation, upregulation of the PD-1 ligand PD-L1 on the surface of SKOV3 tumor targets was assessed as it is induced in response to IFN-γ secreted by activated T cells.

AMX-818(PAT) activates Jurkat NFAT-luciferase reporter T cells in the presence of BT-474 cells with EC ₅₀ values in the range of 70 pM compared to masked AMX-818 and AMX-818-P1 The response was significantly attenuated by 4 orders of magnitude compared to that of activated AMX-818(PAT), with a maximal response reduction of 80%-90%. AMX-818(PAT) activation of T cells was not observed in the absence of HER2+ BT-474 tumor cells, suggesting that monovalent engagement of CD3 is not sufficient for activation and that CD3 and tumor targets are required for efficient T cell receptor (TCR) stimulation The joint of the two. Masked AMX-818 metabolites AMX-818(1x-C) and AMX-818(1x-N) alone exhibited moderate activity. The AMX-818-non-cleavable site did not induce detectable T cell activation, suggesting that the observed minimal response to AMX-818 may be driven by proteolytic cleavage.

AMX-818(PAT) and the prodrug AMX-818 induced CD69 and PD-1 expression on the surface of CD4+ T cells and CD8+ T cell subsets and PD-L1 expression to a comparable extent on SKOV3 tumor cells. However, the dose-response curve shift of AMX-818 was on average 400 to 650 times higher than that of AMX-818(PAT), further confirming the effective function of the XTEN mask on AMX-818 Sexual masking.

The cytotoxic activity and inflammatory cytokine induction of AMX-818 and its metabolites were characterized. Peripheral blood mononuclear cells (PBMCs) were used as effector cells and the HER2-high BT-747 breast tumor line was selected as tumor target cells. Because cardiac tissue is known to express HER2 and although rare cardiotoxicity has been observed in patients treated with some HER2-targeted therapies, primary cardiomyocytes (low to moderate HER2) were chosen to express AMX-818 and its proteolytic metabolism A more physiological target of cytolysis. Luminescence-based cytotoxicity assays were performed at a 1:1 effector:target cell ratio, and cell-free supernatants were collected for measurement of TCE-induced cytokines.

AMX-818(PAT) exhibits highly potent cytotoxicity against BT-474 tumor cells, exhibiting almost complete killing of target cells with half maximal inhibitory concentration (IC ₅₀ ) values in the range of 5-11 pM. With lower HER2 expressing human cardiomyocytes targeted - cells not expected to exhibit dysregulated protease activity - the cytotoxic response was reduced roughly 13-fold, and the maximal kill was incomplete, only approaching 50%-60%. The cytotoxic response of AMX-818 against BT-474 cells and cardiomyocytes was strongly attenuated, where the average _IC50 values were shifted by 2500-fold to 3000-fold, indicating that the effective functionality of the prodrug is masked by the XTEN polymer of the prodrug shaded. Masks provide synergistic protection in terms of cytotoxicity that far outweighs their combined effects on reducing target binding by impeding the formation of functional immune synapses required to initiate target cell killing. AMX-818 and its prototype, AMX-818-P1, displayed comparable cytotoxicity consistent with its nearly identical composition. The cytotoxicity of masked proteolytic metabolites AMX-818(1x-N) and AMX-818(1x-C) alone was moderate between AMX-818(PAT) and AMX-818, indicating that a single mask part of the protection. The observed cytotoxicity of AMX-818 may be due to proteolytic cleavage based on further reduced activity provided by the AMX-818-non-cleavable site, a format that does not have two protease cleavage sites.

In general, the relative potency of AMX-818 and its metabolites in inducing cytokine secretion in supernatants was analyzed based on cytotoxicity versus that observed in cytotoxicity against both BT-474 and cardiomyocyte target cells. Equivalent relative potencies were mirror images (with AMX-818 (PAT) most potent > masked form alone > and AMX-818 least potent). The _IC50 values for the cytokines were on average higher than those for the cytotoxic response, suggesting that cytotoxicity is the more sensitive assay of the two. Responses to AMX-818 in the presence of both BT-474 and cardiomyocytes were orders of magnitude reduced relative to responses to AMX-818(PAT), while masked metabolite AMX-818 alone (1x-N ) and AMX-818 (1x-C) showed moderate responses.

In the presence of cardiomyocytes, AMX-818 at its highest tested concentration (300 nM) induced a marked reduction in the maximum amount of interleukin relative to that induced by AMX-818(PAT), IL -6 except. In the presence of both BT-474 and cardiomyocytes, high IL-6 levels were detected at 300 nM concentration of both AMX-818 and AMX-818-non-cleavable site, which were in most cases 2 to 6 times higher than the maximum content produced by AMX-818 (PAT). Notably, this is in contrast to what was observed in vivo in cynomolgus monkeys, where peak systemic levels of IL-6 were at 0.2 mg/kg MTD of AMX-818 (PAT) compared with 42 mg/kg The MTD of AMX-818 was > 9 times higher.

In assessing interleukin induction in the absence of HER2-expressing target cells, interleukin IL was not induced in human PBMC cultures treated with AMX-818 or AMX-818(PAT) in suspension and plated -2, IL-4, TNF-α and IFN-γ. Soluble AMX-818 induced low levels of IL-10 from all PBMC donors at its highest tested concentration (500 nM). IL-6 was the notable exception where 500 nM AMX-818 in soluble format induced IL-6 levels from all donors over that induced by the anti-CD3 antibody positive control in a manner that increased by an average of 4.6 fold. High levels of IL-6 were also induced by 2 of 5 donors in wet pan coating format, and lower levels of IL-6 were also seen at the highest concentration of AMX-818 (PAT). Importantly, however, these high IL-6 levels were not accompanied by increases in TNF-α, IFN-γ and IL-2, which are interkines normally co-correlated with IL-6 secretion under CRS conditions, nor did they Observed in cynomolgus monkeys dosed with up to 50 mg/kg of AMX-818. In contrast, activated AMX-818(PAT) induced high levels of IL-6 in cyno at ≤ 0.3 mg/kg, accompanied by an increase in additional inflammatory cytokines.

In vivo pharmacology, PK and toxicology studies were conducted to characterize the efficacy and safety of AMX-818 and its metabolites. In addition to standard toxicology endpoints, following long-term incubation in plasma from patients with cancer or systemic autoimmune diseases, crab-eating animals administered high doses of AMX-818 or under conditions of induced inflammation The proteolytic stability of AMX-818 in circulation was assessed in macaques and in vitro . Preferential cleavage of AMX-818 in tumors is evident, resulting in protease-dependent efficacy, while its peripheral stability in NHPs provides a large safety margin relative to AMX-818(PAT) predicting increased therapeutic index . Together, these data support a strong conditional masking of AMX818, enabling localized tumor activity in the circulation and surrounding tissue with simultaneous stability and effective masking.

Several in vivo efficacy studies were performed to evaluate the effect of AMX-818 in the killing of HER2-expressing tumors by redirected T cells. Because AMX-818 is not cross-reactive to mouse HER2 or CD3, immunodeficient mice were inoculated with human HER2-expressing xenograft tumors and transplanted with human PBMCs (hPBMCs) as a source of effector T cells. The antitumor activity of AMX-818 was evaluated in the HER2-high BT-474 breast model (~975,000 HER2 receptors) and the HER2-low HT-55 colorectal model (25,000 receptors).

In the BT474 model, administration of 2.1 mg/kg equimolar doses of AMX-818 and its prototype AMX-818-P1 or 0.9 mg/kg equimolar doses of unmasked AMX-818 (PAT) induced robust and complete tumor regression. The antitumor efficacy of AMX-818 is dependent on its masked protease cleavage as absent in mice treated with a form of AMX-818 that does not have its protease release site (AMX-818-non-cleavable site) Significant tumor growth inhibition was demonstrated. AMX-818-P1 and AMX-818(PAT) induced comparable T cell activation in the tumor microenvironment, as demonstrated by upregulation of the activation markers CD25 and CD69 on CD4+ T cells and CD8+ T cells using flow cytometry Assessed. Importantly, even unmasked AMX-818(PAT) in which human HER2 was not expressed did not activate T cells in the periphery, which is consistent with double engagement of both HER2 and CD3 to activate T cells and redirect The requirements for their killing are the same.

A single 2.1 mg/kg dose of AMX-818 was sufficient to induce tumor regression within 4 days of administration in mice bearing large established BT ^- 474 tumors (478 mm mean tumor volume). Efficacy depends on both HER2 expression and T cells, as demonstrated by administration in tumor-bearing mice without hPBMCs that do not have the non-tumor-binding variant NB-XPAT (a version of AMX-818 in which its HER2 The binding domain was demonstrated by the activity of non-HER2 binding scFv) or AMX-818. These findings further support the requirement for AMX-818 to double engage for its activity and provide a safety measure if AMX-818 becomes cleaved in normal tissues where HER2 is absent.

In mice bearing HER2-low HT-55 tumors, AMX-818 also induced dose- and protease-dependent efficacy, with 5.1 mg/kg inducing complete tumor regression in all mice (103% TGI, p<0.01) And 2.1 mg/kg induced 70% tumor growth inhibition. The efficacy of AMX-818 in a model expressing 25,000 HER2 receptors offers the potential to treat patients with a variety of cancer types, including tumors with low levels of HER2 expression. Finally, in BT-474 tumor-bearing mice, after 2 days of incubation, fluorophore-labeled AMX-818 was preferentially unmasked by an average of 25.2% compared to pooled <2% in heart, brain, and liver tissues AMX-818(PAT) is evident in tumors, supporting a key tenant of local dysregulation of proteases in tumors and dominant protease inhibition in normal tissues. the term

Unless otherwise specified, the following terms as used herein have the meanings ascribed to those terms.

As used in the specification and claims, the singular forms "a" and "the" include plural referents unless the context clearly dictates otherwise. For example, the term "a cell" includes a plurality of cells, including mixtures thereof.

The terms "polypeptide," "peptide," and "protein" are used interchangeably herein to refer to a polymer of amino acids of any length. The polymer may be linear or branched, it may comprise modified amino acids, and it may be interspersed with non-amino acids. These terms also encompass amino acid polymers that have been modified, eg, by disulfide bond formation, glycation, lipidation, acetylation, phosphorylation, or any other manipulation such as association with a labeling component.

The term "amino acid" as used herein refers to natural and/or non-natural or synthetic amino acids, including but not limited to glycine and both the D optical isomer or the L optical isomer and the amino acid Analogs and peptidomimetics. Standard one-letter or three-letter codes are used to designate amino acids.

A "host cell" includes an individual cell or cell culture that can be or has been a recipient of a vector of the invention. A host cell includes progeny of a single host cell. Due to naturally occurring or genetically engineered variants, the progeny may not necessarily be identical (either in morphology or in the genome of the total DNA complement) to the original parent cell.

A "chimeric" protein comprises at least one fusion polypeptide comprising a region in a position in a sequence that differs from the position in the naturally occurring sequence. These regions may be normally present in separate proteins and joined together in the fusion polypeptide; or they may be normally present in the same protein but placed in a new configuration in the fusion polypeptide. Chimeric proteins can be produced, for example, by chemical synthesis or by production and translation of polynucleotides in which the peptide regions are encoded in the desired relationship.

"Conjugated", "linked", and "fused/fusion" are used interchangeably herein. These terms refer to the joining together of more than two chemical elements or components by any means including chemical bonding or recombinant means.

The terms "polynucleotide", "nucleic acid", "nucleotide" and "oligonucleotide" are used interchangeably. It refers to nucleotides of any length in polymeric form, ie deoxyribonucleotides or ribonucleotides, or analogs thereof. A polynucleotide can have any three-dimensional structure and can perform any function, known or unknown. A polynucleotide may comprise modified nucleotides such as methylated nucleotides and nucleotide analogs. If present, modifications can be imparted to the nucleotide structure either before or after assembly of the polymer. The sequence of nucleotides may be interspersed with non-nucleotide components. Polynucleotides may be further modified after polymerization, such as by incorporation of labeling components.

As used herein, polynucleotides having "homology" or "homologous" polynucleotides are polynucleotides that hybridize under stringent conditions as defined herein and share at least 70%, preferably at least 80%, with their sequences , more preferably at least 90%, more preferably 95%, more preferably 97%, more preferably 98% and even more preferably 99% sequence identical polynucleotides.

The terms "percent identity" and "% identity" as applied to polynucleotide sequences refer to the percentage of residue matches between at least two polynucleotide sequences aligned using a normalization algorithm. Such algorithms can insert gaps in compared sequences in a standardized and reproducible manner in order to optimize the alignment between the two sequences and thus achieve a more meaningful comparison of the two sequences. The percent identity can be measured over the length of the entire defined polynucleotide sequence, e.g. as defined by a particular SEQ ID number, or can be measured over a shorter length, e.g. A fragment obtained from a larger defined polynucleotide sequence, for example a fragment of at least 45, at least 60, at least 90, at least 120, at least 150, at least 210 or at least 450 contiguous residues is measured in length. These lengths are exemplary only and it is understood that any fragment length supported by the sequences shown herein in tables, figures or sequence listings can be used to describe lengths for which a measurable percentage of identity can be described.

"Percent amino acid sequence identity (%)" with respect to polypeptide sequences identified herein is defined as aligning the sequences and introducing gaps where necessary to achieve the maximum percent sequence identity and not considering any conservative substitutions as sequence Following a portion of identity, the percent identity of the amino acid residues in the query sequence to the amino acid residues of the second reference polypeptide sequence or portion thereof. Alignment for purposes of determining percent amino acid sequence identity can be achieved in various ways within the art, for example, using publicly available computer software such as BLAST, BLAST-2, ALIGN or Megalign (DNASTAR) software. Those skilled in the art can determine suitable parameters for measuring alignment, including any algorithms needed to achieve maximal alignment over the full length of the sequences being compared. The percent identity can be measured over the length of the entire defined polypeptide sequence, e.g. as defined by a particular SEQ ID number, or can be measured over a shorter length, e.g. A fragment of a defined polypeptide sequence, for example a fragment having at least 15, at least 20, at least 30, at least 40, at least 50, at least 70 or at least 150 consecutive residues is measured in length. These lengths are exemplary only and it is understood that any fragment length supported by the sequences shown herein in tables, figures or sequence listings can be used to describe lengths for which a measurable percentage of identity can be described.

"Repeatability" of an XTEN sequence as used herein refers to 3-mer repeatability and can be measured by a computer program or algorithm or by other means known in the art. The 3-mer repeatability of XTEN was assessed by determining the number of occurrences of overlapping 3-mer sequences within the polypeptide. For example, a polypeptide of 200 amino acid residues has 198 overlapping 3-amino acid sequences (3mers), but the number of unique 3mer sequences will depend on the amount of repeats within the sequence. A score (hereinafter "subsequence score") can be generated that reflects the degree of repetition of 3-mers throughout the polypeptide sequence. In the context of the present invention, "subsequence score" means the sum of the occurrences of each unique 3-mer framework in a 200 contiguous amino acid sequence of a polypeptide divided by the unique 3-mer subsequence within the 200 amino acid sequence the absolute number. Examples of such subsequence scores derived from the first 200 amino acids of repetitive and non-repetitive polypeptides are presented in Example 73 of International Patent Application Publication No. WO 2010/091122 A1, which is incorporated by reference in its entirety . In some embodiments, the invention provides BPXTENs each comprising an XTEN, wherein the XTEN may have a subsequence score of less than 16, or less than 14, or less than 12, or more preferably less than 10.

The term "substantially non-repetitive XTEN" as used herein refers to an XTEN in which (1) there are few or no instances of four consecutive amino acids of the same amino acid type in the sequence of the XTEN, and in which (2) the XTEN Having a subsequence score (defined in the preceding paragraph herein) of 12 or 10 or lower, or the absence of a pattern in N-terminal to C-terminal order of the sequence motifs that make up the polypeptide sequence.

A "vector" is a nucleic acid molecule, preferably autonomously replicating in a suitable host, which delivers an inserted nucleic acid molecule into and/or between host cells. The term includes vectors that function primarily to insert DNA or RNA into a cell, vector copies that function primarily to replicate DNA or RNA, and expression vectors that function primarily to transcribe and/or translate DNA or RNA. Also included are vectors that provide more than one of the above functions. An "expression vector" is a polynucleotide that can be transcribed and translated into polypeptide(s) when introduced into an appropriate host cell. "Expression system" generally means a suitable host cell consisting of an expression vector that can be used to produce a desired expression product.

The term "t _1/2 " as used herein means the terminal half-life calculated as In(2)/K _el . _Kel is the terminal elimination rate constant calculated by linear regression of the terminal linear portion of the log concentration versus time curve. Half-life generally refers to the time required for half the amount of an administered substance deposited in a living organism to be metabolized or eliminated by normal biological processes. The terms "t _1/2 ", "terminal half-life", "elimination half-life" and "circulation half-life" are used interchangeably herein.

The terms "antigen", "antigen of interest" or "immunogen" are used interchangeably herein to refer to a structure or binding determinant to which an antibody fragment or antibody fragment-based therapeutic agent binds or has specificity.

The term "payload" as used herein refers to a protein or peptide sequence having biological or therapeutic activity; the counterpart of the pharmacophore of a small molecule. Examples of payloads include, but are not limited to, cytokines, enzymes, hormones, and blood and growth factors. The payload may further comprise genetically fused or chemically bound moieties such as chemotherapeutics, antiviral compounds, toxins or contrast agents. These binding moieties can be joined to the remainder of the polypeptide via cleavable or non-cleavable linkers.

As used herein, "treatment/treating", "palliating" and "ameliorating" are used interchangeably herein. These terms refer to methods of obtaining beneficial or desired results including, but not limited to, therapeutic benefit and/or prophylactic benefit. "Therapeutic benefit" means eradication or amelioration of the underlying condition being treated. Furthermore, therapeutic benefit is achieved when one or more of the physical symptoms associated with the underlying disease condition is eradicated or ameliorated such that improvement is observed in the individual, although the individual may still be suffering from the underlying condition. For prophylactic benefit, compositions may be administered to individuals at risk of developing a particular disease or condition, or to individuals reporting one or more of the physical symptoms of a disease, even though the disease may not have been diagnosed.

As used herein, "therapeutic effect" means a physiological effect, including but not limited to curing, alleviating, ameliorating or preventing a disease condition in a human or other animal, or otherwise enhancing the physical or mental health of a human or animal, as determined by In addition to the ability to induce the production of antibodies against the epitope possessed by the biologically active protein, the fusion polypeptide of the present invention causes. Determination of a therapeutically effective amount is well within the capability of those skilled in the art, especially in light of the detailed disclosure provided herein.

The terms "therapeutically effective amount" and "therapeutically effective dose" as used herein refer to an amount capable of having an effect on any symptom, aspect, measurement parameter or characteristic of a disease state or condition when administered to a subject in one or repeated doses. The amount of biologically active protein alone or as part of a fusion protein composition for any detectable beneficial effect. The effect need not be absolutely beneficial. A disease condition may refer to a disorder or a disease.

As used herein, the term "therapeutically effective dosage regimen" refers to a schedule of sequentially administered doses of a biologically active protein, alone or as part of a fusion protein composition, wherein the doses are administered in a therapeutically effective amount to treat a disease state or condition Any symptom, aspect, measure, or characteristic of the drug produces a sustained beneficial effect. fusion peptide

The disclosure herein includes a polypeptide (or fusion polypeptide) comprising one or more expanded recombinant polypeptides (one or more XTENs) (as described more fully below), a bispecific antibody construct linked to the XTEN(s) ( BsAb ) and one or more release segments ( RS ); the release segment is located between the XTEN and the bispecific antibody construct ( BsAb ); and the polypeptide (or fusion polypeptide) has an N-terminal amino acid and a C-terminal amino acid acid.

In some embodiments, the polypeptide comprises a first XTEN (such as an XTEN described in the "Expanded Recombinant Polypeptides (XTEN)" section below or described anywhere else herein). In some embodiments, the polypeptide further comprises a second XTEN (such as an XTEN described in the "Expanded Recombinant Polypeptides (XTEN)" section below or described anywhere else herein). In some embodiments, a polypeptide comprises an XTEN at or near its N-terminus ("N-terminal XTEN"). In some embodiments, a polypeptide comprises an XTEN at or near its C-terminus ("C-terminal XTEN"). In some embodiments, the polypeptide comprises both an N-terminal XTEN and a C-terminal XTEN. In some embodiments, the first XTEN is an N-terminal XTEN and the second XTEN is a C-terminal XTEN. In some embodiments, the first XTEN is a C-terminal XTEN and the second XTEN is an N-terminal XTEN.

As a bispecific antibody (BsAb), a biologically active polypeptide ("BP") is linked to one or more XTEN within the polypeptide, which may be referred to as a fusion polypeptide containing XTEN: "BPXTEN".

The XTEN can comprise one or more barcode fragments that can be released (configured to release) from the XTEN following protease digestion of the fusion polypeptide (or BPXTEN) (as described more fully below). In some embodiments, each barcode fragment differs in sequence and molecular weight from all other peptide fragments that can be released from the polypeptide upon complete protease digestion of the polypeptide, including all other barcode fragments, if present.

The (fusion) polypeptide may comprise one or more reference fragments (as described more fully below) that may be released (configured to release) from the polypeptide, eg, following protease digestion to release the barcode fragment(s) from the polypeptide. In some embodiments, each reference fragment may be a single reference fragment that differs in sequence and molecular weight from all other peptide fragments that may be released from the polypeptide following protease digestion of the polypeptide.

In some embodiments, the polypeptide has an N-terminal amino acid and a C-terminal amino acid. A polypeptide may comprise: (a) an expanded recombinant polypeptide ( XTEN ) comprising a barcode fragment ( BAR ) that can be released from the polypeptide following protease digestion; (b) a bispecific antibody construct ( BsAb ) comprising a specific binding to the first antigen-binding fragment ( AF1 ) of cluster of differentiation 3 T cell receptor (CD3), the AF1 comprising light chain complementarity determining regions 1 (CDR-L1), 2 (CDR-L2) and 3 (CDR-L3) and Heavy chain complementarity determining regions 1 (CDR-H1), 2 (CDR-H2) and 3 (CDR-H3), wherein CDR-H3 comprises the amino acid sequence of SEQ ID NO: 10 ; and specifically binds to human epidermal growth a second antigen-binding fragment ( AF2 ) of factor receptor 2 (HER2); and (c) a releasing segment ( RS ) positioned between the XTEN and the bispecific antibody construct, wherein the XTEN is characterized by: (i) It comprises at least 100 or at least 150 amino acids; (ii) at least 90% of its amino acid residues are represented herein by glycine (G), alanine (A), serine (S) , threonine (T), glutamic acid (E) or proline (P); (iii) it contains at least 4 different types of amino acids, which are referred to herein by G , A, S, T, E, or P; and (iv) the XTEN is formed from a plurality of non-overlapping sequence motifs, each of which is 9 to 14 amino acids in length, wherein the The plurality of non-overlapping sequence motifs comprises: (1) a set of non-overlapping sequence motifs, wherein each non-overlapping sequence motif in the set of non-overlapping sequence motifs is repeated at least twice in the XTEN; and (2) a non-overlapping sequence motif An overlapping sequence motif that occurs only once within the XTEN; wherein the barcode segment ( BAR ) includes at least a portion of a non-overlapping sequence motif that occurs only once within the XTEN; wherein the barcode segment ( BAR ) is compatible with the polypeptide after complete digestion of the polypeptide by a protease All other peptide fragments released from the polypeptide differ in sequence and molecular weight; and wherein the barcode fragment ( BAR ) does not include the N-terminal amino acid or the C-terminal amino acid of the polypeptide. Polypeptides can be expressed as fusion proteins. A fusion protein in an uncleaved state may have a fusion protein from N-terminus to C-terminus defined herein by AF1-AF2-RS-XTEN, AF2-AF1-RS-XTEN, XTEN-RS-AF1-AF2 or XTEN-RS-AF2- Structural arrangement marked by AF1.

In some embodiments of the polypeptide of the present invention, XTEN is the first expanded recombinant polypeptide ( XTEN1 ); the plurality of non-overlapping sequence motifs forming XTEN1 are the first plurality of non-overlapping sequence motifs; BAR is the first barcode fragment ( BAR1 ); and RS is the first release segment ( RS1 ). In some embodiments, the polypeptide may further comprise: (d) a second expanded recombinant polypeptide ( XTEN2 ) comprising: a second barcode segment ( BAR2 ) releasable from the polypeptide following protease digestion; and (e) a second A release segment ( RS2 ) located between the second XTEN ( XTEN2 ) and the bispecific antibody construct ( BsAb ), wherein XTEN2 is characterized in that: (i) it comprises at least 100 or at least 150 amino acids; (ii) at least 90% of its amino acid residues are represented herein by glycine (G), alanine (A), serine (S), threonine (T), glutamic acid (E ) or proline (P); and (iii) it comprises at least 4 different types of amino acids identified herein by G, A, S, T, E or P ; wherein the second barcode fragment ( BAR2 ) differs in sequence and molecular weight from all other peptide fragments that can be released from the polypeptide after complete digestion of the polypeptide by a protease; and wherein the second barcode fragment ( BAR2 ) does not include the N-terminus of the polypeptide Amino acid or C-terminal amino acid. XTEN1 can be located at the N-terminus of the bispecific antibody construct (BsAb) and XTEN2 can be located at the C-terminus of the bispecific antibody construct (BsAb). Alternatively, XTEN1 can be located at the C-terminus of the bispecific antibody construct (BsAb) and XTEN2 can be located at the N-terminus of the bispecific antibody construct (BsAb). In some embodiments of the polypeptide, wherein (iv) XTEN2 can be formed from a second plurality of non-overlapping sequence motifs, each of the second plurality of non-overlapping sequence motifs is 9 to 14 amino acids in length, wherein the second The plurality of non-overlapping sequence motifs comprises: (1) a second set of non-overlapping sequence motifs, wherein each non-overlapping sequence motif in the second set of non-overlapping sequence motifs is repeated at least twice in the second XTEN; and ( 2) A non-overlapping sequence motif that occurs only once in the second XTEN; and wherein the second barcode segment ( BAR2 ) includes at least a portion of the non-overlapping sequence motif that occurs only once in the second XTEN. Polypeptides can be expressed as fusion proteins, wherein the fusion protein in the uncleaved state can have from the N-terminus to the C-terminus as described herein by XTEN1-RS1-AF1-AF2-RS2-XTEN2, XTEN1-RS1-AF2-AF1-RS2 -XTEN2, XTEN2-RS2-AF1-AF2-RS1-XTEN1, XTEN2-RS2-AF2-AF1-RS1-XTEN1, XTEN1-RS1-Biabody-RS2-XTEN2 or XTEN2-RS2-Biabody-RS1-XTEN1 The structural arrangement to be identified. The diabody can comprise the light chain variable region (VL _I ) of the AF1, the heavy chain variable region (VH _I ) of the AF1, the light chain variable region (VL _II ) of the AF2 and the heavy chain of the AF2 Variable region (VH _II ).

In some embodiments of the polypeptides of the present invention, (a) the first expanded recombinant polypeptide ( XTEN1 ) may comprise at least about 90%, 91%, 92%, 93%, 94% of the sequence set forth in Table 3a , 95%, 96%, 97%, 98%, 99% or 100% sequence identity amino acid sequence; (b) bispecific antibody construct ( BsAb ) may comprise: (I) a first antigen-binding fragment ( AF1 ), which comprises light chain complementarity determining regions 1 (CDR-L1), 2 (CDR-L2) and 3 (CDR-L3) and heavy chain complementarity determining regions 1 (CDR-H1), 2 (CDR-H2) and 3 (CDR-H3), wherein CDR-H1, CDR-H2 and CDR-H3 respectively comprise the amino acid sequences of SEQ ID NO: 8 , 9 and 10 ; and (II) the second antigen-binding fragment ( AF2 ), It comprises a light chain variable region (VL _II ) identified herein by SEQ ID NOs: 778-783 and a heavy chain variable region (VH _II ) identified herein by SEQ ID NOs: 878-883 ); (c) the first release segment ( RS1 ) comprises at least 90%, 91%, 92%, 93%, 94%, 95% of the sequence identified herein by SEQ ID NO: 7001-7626 , 96%, 97%, 98%, 99% or 100% amino acid sequence identity sequence; (d) the second expanded recombinant polypeptide ( XTEN2 ) comprising at least about 90% of the sequence set forth in Table 3a , 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% sequence identity of amino acid sequences; and (e) the second release segment ( RS2 ) comprises at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% of the sequence identified herein by SEQ ID NO: 7001-7626 or an amino acid sequence with 100% sequence identity, wherein the polypeptide may have a structural arrangement identified herein from the N-terminus to the C-terminus by: XTEN1-RS1-AF2-AF1-RS2-XTEN2, XTEN1-RS1- AF1-AF2-RS2-XTEN2, XTEN2-RS2-AF2-AF1-RS1-XTEN1, or XTEN2-RS2-AF1-AF2-RS1-XTEN1. Extended Recombinant Peptide (XTEN) Chain Length and Amino Acid Composition

In some embodiments, the XTEN comprises at least 100 or at least 150 amino acids. In some embodiments, the XTEN is 100 to 3,000 or 150 to 3,000 amino acids in length. In some embodiments, the XTEN is 100 to 1,000 or 150 to 1,000 amino acids in length. In some embodiments, the XTEN has a length of at least (about) 100, at least (about) 150, at least (about) 200, at least (about) 250, at least (about) 300, at least (about) 350 at least (about) 400, at least (about) 450, at least (about) 500, at least (about) 550, at least (about) 600, at least (about) 650, at least (about) 700 , at least (about) 750, at least (about) 800, at least (about) 850, at least (about) 900, at least (about) 950, at least (about) 1,000, at least (about) 1,100, at least (about) 1,200, at least (about) 1,300, at least (about) 1,400, at least (about) 1,500, at least (about) 1,600, at least (about) 1,700, at least (about) 1,800, at least (approximately) 1,900 or at least (approximately) 2,000 amino acids. In some embodiments, the XTEN is at most (about) 100, at most (about) 150, at most (about) 200, at most (about) 250, at most (about) 300, at most (about) 350 in length Up to (about) 400 Up to (about) 450 Up to (about) 500 Up to (about) 550 Up to (about) 600 Up to (about) 650 Up to (about) 700 , up to (about) 750, up to (about) 800, up to (about) 850, up to (about) 900, up to (about) 950, up to (about) 1,000, up to (about) 1,100, Up to (about) 1,200, up to (about) 1,300, up to (about) 1,400, up to (about) 1,500, up to (about) 1,600, up to (about) 1,700, up to (about) 1,800, up to (about) 1,900 or up to (about) 2,000 amino acids. In some embodiments, the XTEN is (about) 100, (about) 150, (about) 200, (about) 250, (about) 300, (about) 350, (about) 400 in length pcs, (about) 450 pcs, (about) 500 pcs, (about) 550 pcs, (about) 600 pcs, (about) 650 pcs, (about) 700 pcs, (about) 750 pcs, (about) 800 pcs, (about) 850, (about) 900, (about) 950, (about) 1,000, (about) 1,100, (about) 1,200, (about) 1,300, (about) 1,400, (about) ) 1,500, (about) 1,600, (about) 1,700, (about) 1,800, (about) 1,900 or (about) 2,000 amino acids or a range between any two of the foregoing. In some embodiments, at least 90% of the amino acid residues of the XTEN are represented herein by glycine (G), alanine (A), serine (S), threonine (T), gluten Amino acid (E) or proline (P) to identify. In some embodiments, at least 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% of the amino acid residues of the XTEN are glycine (G ), alanine (A), serine (S), threonine (T), glutamic acid (E) or proline (P). In some embodiments, the XTEN comprises at least 4 different types of amino acids, which are G, A, S, T, E, or P, relative to any other non-overlapping sequence motif comprising an XTEN polypeptide essentially randomized. In some embodiments, the XTEN (e.g., XTEN1, XTEN2, etc.) is characterized in that: (i) it comprises at least 100 or at least 150 amino acids; (ii) at least 90% of the amino acid residues of the XTEN are Glycine (G), Alanine (A), Serine (S), Threonine (T), Glutamine (E) or Proline (P); and (iii) which contain at least 4 The different types of amino acids, from G, A, S, T, E or P, are substantially randomized relative to any other non-overlapping sequence motif comprising XTEN polypeptides. Those of ordinary skill in the art will understand that the term "glutamate" as used herein is synonymous with "glutamic acid" and refers to the residue of glutamic acid, regardless of whether the side chain carboxyl group is Deprotonated. In some embodiments, an XTEN-containing fusion polypeptide comprises a first XTEN and a second XTEN. In some embodiments, the sum of the total number of amino acids in the first XTEN and the total number of amino acids in the second XTEN is at least 300, at least 350, at least 400, at least 500, at least 600, at least 700 or at least 800 amino acids. non-overlapping sequence motif

In some embodiments, the XTEN comprises or is formed from a plurality of non-overlapping sequence motifs. In some embodiments, at least one of the non-overlapping sequence motifs is cyclic (or repeated at least twice in XTEN), and wherein at least one other of the non-overlapping sequence motifs is acyclic (or repeated at least twice in XTEN) Exists only once within XTEN). In some embodiments, the plurality of non-overlapping sequence motifs comprises (a) a set (cyclic) of non-overlapping sequence motifs, wherein each non-overlapping sequence motif in the set of non-overlapping sequence motifs is repeated at least two times in the XTEN times; and (b) a non-overlapping (non-cyclic) sequence motif that occurs (or exists) only once within the XTEN. In some embodiments, each non-overlapping sequence motif is 9-14 (or 10-14 or 11-13) amino acids in length. In some embodiments, each non-overlapping sequence motif is 12 amino acids in length. In some embodiments, the plurality of non-overlapping sequence motifs comprises a set of non-overlapping (cyclic) sequence motifs, wherein each non-overlapping sequence motif (1) in the set of non-overlapping sequence motifs is repeated at least two times in the XTEN times; and (2) between 9 and 14 amino acids in length. In some embodiments, the set of (circular) non-overlapping sequence motifs comprises the 12-mer sequence motifs identified herein by SEQ ID NOs: 179-200 and 1715-1722 in Table 1 . In some embodiments, the set of (circular) non-overlapping sequence motifs comprises the 12mer sequence motifs identified herein by SEQ ID NOs: 186-189 in Table 1 . In some embodiments, the set of (circular) non-overlapping sequence motifs comprises at least two, at least three or all four of the 12-mer sequence motifs of SEQ ID NO: 186-189 in Table 1 . Table 1. Exemplary 12-mer sequence motifs for construction of XTEN Phantom Family* amino acid sequence SEQ ID NO. AD GESPGGSSGSES 182 AD GSEGSSGPGESS 183 AD GSSESGSSEGGP 184 AD GSGGEPSESGSS 185 AE, AM GSPAGSPTSTEE 186 AE, AM, AQ GSEPATSGSETP 187 AE, AM, AQ GTSESATPESGP 188 AE, AM, AQ GTSTEPSEGSAP 189 AF, AM GSTSESPSGTAP 190 AF, AM GTSTPESGSASP 191 AF, AM GTSPSGESSTAP 192 AF, AM GSTSSTAESPGP 193 AG, AM GTPGSGTASSSP 194 AG, AM GSSTPSGATGSP 195 AG, AM GSSPSASTGTGP 196 AG, AM GASPGTSSTGSP 197 AQ GEPAGSPTSTSE 198 AQ GTGEPSSTPASE 199 AQ GSGPSTESAPTE 200 AQ GSETPSGSETA 179 AQ GPSETSTSEPGA 180 AQ GSPSEPTEGTSA 181 BC GSGASEPTSTEP 1715 BC GSEPATSGTEPS 1716 BC GTSEPSTSEPGA 1717 BC GT STEPS EPGSA 1718 BD GSTAGSETSTEA 1719 BD GSETATSGSETA 1720 BD GTSESATSESGA 1721 BD GTSTEASEGASAS 1722 *Indicates individual motif sequences that, when used together in various permutations, generate "family sequence" barcode fragments

In some embodiments, the polypeptide comprises a barcode segment ( eg , the first barcode segment, the second barcode segment, or the third barcode segment of XTEN) that is releasable from the polypeptide upon protease digestion. In some embodiments, the barcode segment (1) is a portion of an XTEN that includes at least a portion of a (non-cyclic, non-overlapping) sequence motif that occurs (or exists) only once within the XTEN; All other peptide fragments that can be released from a polypeptide after digestion of the polypeptide differ in sequence and molecular weight. Those of ordinary skill in the art will understand that the term "barcode fragment" (or "barcode" or "barcode sequence") may refer to a portion of a fused XTEN that is cleavable within a polypeptide or the resulting peptide fragment that is released from the polypeptide.

In some embodiments, the barcode fragment does not include the N-terminal amino acid or the C-terminal amino acid of the polypeptide. As described more fully below or described anywhere herein, in some embodiments, the barcode fragments are releasable (configured to be released) upon Glu-C digestion of the fusion polypeptide. In some embodiments, the barcode fragment does not include a glutamic acid that is immediately adjacent to another glutamic acid (if present) in the XTEN. In some embodiments, the barcode fragment has glutamic acid at its C-terminus. Those of ordinary skill in the art will appreciate that when cleavably fused within an XTEN, the C-terminus of the barcode fragment may refer to the "last" (or most C-terminal) amino acid residue within the barcode fragment, even if other "non-terminal" amino acid residues are present. The "barcode" amino acid residues are located at the C-terminus of the barcode fragments within the same XTEN. In some embodiments, the barcode fragment has an N-terminal amino acid immediately following the glutamic acid residue. In some embodiments, the glutamic acid residue preceding the N-terminal amino acid is not immediately adjacent to another glutamic acid residue. In some embodiments, the barcode fragment does not include a (second) glutamic acid residue at positions other than the C-terminus of the barcode fragment, unless the glutamic acid is immediately followed by a proline. In some embodiments, the barcode segment is positioned at a distance from the N-terminus of the polypeptide or the C-terminus of the polypeptide, wherein the distance is 10 to 150 or 10 to 125 amino acids. In some embodiments, the barcode segment is located 300, 280, 260, 250, 240, 220, 200, 190, 180, 170, 160, 150, 140, 130, 120, 110, 100, 90, 80, 70, 60, 50, 48, 40, 36, 30, 24, 20, 12 or 10 amino acids or at a position within or within a range between any of the foregoing. In some embodiments, the barcode segment is located within 200 amino acids, within 150 amino acids, within 100 amino acids, or within 50 amino acids of the N-terminus of the polypeptide. In some embodiments, the barcode segment is located between 10 and 200, between 30 and 200, between 40 and 150, or between 50 and 100 amino acids from the N-terminus of the polypeptide. location. In some embodiments, the barcode segment is located 300, 280, 260, 250, 240, 220, 200, 190, 180, 170, 160, 150, 140, 130, 120, 110, 100, 90, 80, 70, 60, 50, 48, 40, 36, 30, 24, 20, 12 or 10 amino acids or at a position within or within a range between any of the foregoing. In some embodiments, the barcode segment is located within 200 amino acids, within 150 amino acids, within 100 amino acids, or within 50 amino acids of the C-terminus of the polypeptide. In some embodiments, the barcode segment is located between 10 and 200, between 30 and 200, between 40 and 150, or between 50 and 100 amino acids from the C-terminus of the polypeptide. location. In some embodiments, the barcode fragment (BAR) is characterized in that: (i) it does not include a glutamic acid immediately adjacent to another glutamic acid in the XTEN (if present); (ii) it has a glutamic acid at its C-terminus; amino acid; (iii) it has an N-terminal amino acid immediately following the glutamic acid residue; and (iv) it is positioned at a distance from the N-terminus of the polypeptide or the C-terminus of the polypeptide, wherein the distance is 10 to 150 amino acids or 10 to 125 amino acids in length. In some embodiments, the barcode fragment (i) does not include the N-terminal amino acid or the C-terminal amino acid of the polypeptide; (ii) does not include a glutamic acid immediately adjacent to another glutamic acid in the XTEN; has glutamic acid at its C-terminus; (iv) has an N-terminal amino acid immediately following the glutamic acid residue; and (v) is located at a distance from the N-terminus of the polypeptide or from the C-terminus of the polypeptide, wherein the distance 10 to 150 or 10 to 125 amino acids in length. In some embodiments, the glutamic acid residue preceding the N-terminal amino acid is not immediately adjacent to another glutamic acid residue. In some embodiments, the barcode fragment does not include a glutamic acid residue at positions other than the C-terminus of the barcode fragment, unless the glutamic acid is immediately followed by a proline. Those skilled in the art generally understand that the term "distance" as used herein may refer to the distance from the N-terminal of the polypeptide to the most N-terminal amino acid residue of the barcode fragment or from the C-terminal of the polypeptide to the most C-terminal of the barcode fragment Amino Acid Residue Number of amino acid residues. In some embodiments, for a barcoded XTEN fused to a biologically active polypeptide, at least one barcode segment (or at least two barcode segments or three barcode segments) contained in the barcoded XTEN is at least 50, 75, 100, 125, 150, 175, 200, 225, 250, 275, 300 amino acid positioning. In some embodiments, the barcode segment is at least 4, at least 5, at least 6, at least 7, or at least 8 amino acids in length. In some embodiments, the barcode segment is at least 4 amino acids in length. In some embodiments, the length of the barcode segment is 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23 , 24, 25 amino acids, or amino acids within a range between any of the preceding values. In some embodiments, the barcode segment is between 4 and 20, between 5 and 15, between 6 and 12, or between 7 and 10 amino acids in length . In some embodiments, the barcode fragments comprise the amino acid sequences identified herein by SEQ ID NOs: 68-77 in Table 2 . Table 2. Exemplary Barcode Fragments Releasable Following Glu-C Digest amino acid sequence SEQ ID NO: SPATSGSTPE 68 (BAR001) GSAPATSE 69 (BAR002) GSAP GTATE 70 (BAR003) GSAPGTE 71 (BAR004) PATSGPTE 72 (BAR005) SASPE 73 (BAR006) PATSGSTE 74 (BAR007) GSAPGTSAE 75 (BAR008) SATS GSE 76 (BAR009) SGPGSTPAE 77 (BAR010)

In some embodiments of the polypeptides of the invention, the XTEN may have a length defined by a proximal end and a distal end, wherein (1) the proximal end is positioned closer to the bispecific antibody construct ( BsAb ) relative to the distal end, and Wherein (2) the barcode segment ( BAR ) may be located within the XTEN extending between 5% and 50%, between 7% and 40%, or between 10% and 30% of the length of the XTEN as measured from the distal end within the area.

In some embodiments of the polypeptides of the invention, the XTEN further comprises one or more additional barcode segments, wherein each of the additional one or more barcode segments is associated with all other peptides that can be released from the polypeptide after complete digestion of the polypeptide by the protease Fragments differ in sequence and molecular weight. In some embodiments, the barcoded XTEN contains only one barcode segment. In some embodiments, the barcoded XTEN comprises a set of barcode segments comprising a first barcode segment, such as the barcode segments described above or anywhere else herein. In some embodiments, the set of barcode segments comprises a second barcode segment (or another barcode segment), such as the barcode segments described above or anywhere else herein. In some embodiments, the set of barcode segments comprises a third barcode segment, such as the barcode segments described above or anywhere else herein. The set of barcode fragments fused within the N-terminal XTEN can be referred to as the N-terminal set of barcodes ("N-terminal set"). The set of barcode fragments fused within the C-terminal XTEN can be referred to as the C-terminal set of barcodes ("C-terminal set"). In some embodiments, the N-terminal set includes a first barcode segment and a second barcode segment. In some embodiments, the N-terminal set further comprises a third barcode segment. In some embodiments, the C-terminal group comprises a first barcode segment and a second barcode segment. In some embodiments, the C-terminal group further comprises a third barcode segment. In some embodiments, the second barcode segment is N-terminal to the first barcode segment in the same group. In some embodiments, the second barcode segment is C-terminal to the first barcode segment in the same group. In some embodiments, the third barcode segment is N-terminal to both the first barcode segment and the second barcode segment. In some embodiments, the third barcode segment is located at the C-terminus of both the first barcode segment and the second barcode segment. In some embodiments, the third barcode segment is located between the first barcode segment and the second barcode segment. In some embodiments, the polypeptide comprises a set of barcode segments, the set of barcode segments comprising a first barcode segment, another (second) barcode segment and at least one additional barcode segment, wherein each barcode segment in the set of barcode segments (1 ) is part of the second XTEN and (2) differs in sequence and molecular weight from all other peptide fragments that can be released from the polypeptide after complete digestion of the polypeptide by a protease. Exemplary XTEN with barcode

13 containing one barcode (for example, SEQ ID NO: 8002-8003 , 8005-8009 and 8013 ) or two barcodes (for example, SEQ ID NO: 8001 , 8004 and 8012 ) or three barcodes (for example, SEQ ID NO: 8011 ) The amino acid sequence of an exemplary barcoded XTEN is illustrated in Table 3a . Among these 13 exemplary barcoded XTENs, six ( SEQ ID NOs: 8001-8003 , 8008-8009 , and 8011 ) were fused to the bioactive protein at the C-terminus of the bioactive protein, and seven ( SEQ ID NO : NO: 8004-8007 , 8010 and 8012-8013 ) are fused at the N-terminus of the biologically active protein. In some embodiments, the XTEN shares at least 90%, at least 92%, at least 95%, at least 98%, at least 99%, or 100% with a sequence identified herein by SEQ ID NO: 8001-8020 in Table 3a % sequence identity. Table 3a. Exemplary Barcoded XTEN SEQ ID NO. XTEN type barcode number amino acid sequence Total number of AAs 8001 C-terminal XTEN 2 PGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGftabTSESATPESGPGSE PATSGPTE SGSEPATSGSETPGSPAGSPTSTEEGTSTEPSE GSAPGTE STPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGEPEA 864 8002 C-terminal XTEN 1 PGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSE PATSGPTE SGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGEPEA 864 8003 C-terminal XTEN 1 PGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSE GSAPGTE STPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGEPEA 864 8004 N-terminal XTEN 2 ASSPAGSPTSTESGTSESATPESGPGTETEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPE SGPGSTPAE SGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSPTTEEGTSESATPESGPGE SPATSGSTPE GTSESATPESGPGSPAGSPTEEGSPAGSPTTEEGTSTEPSEGSAPGTSETSATPESGPGTSESATPSAPGSGPGSEPATSGSETSAPGSEEGSEG 288 8005 N-terminal XTEN 1 ASSPAGSPTSTESGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGE SPATSGSTPE GTSESATPESGPGSPAGSPTEEGSPAGSPTTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGTSEPPSESTSPEGSAPGTSAPGTSAPG 288 8006 N-terminal XTEN 1 ASSPAGSPTSTESGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPE SGPGSTPAE SGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGEEPATSGSTPEGTSESATPESGPGSPAGSPTSTEEGSPAGSTEEGTSTEPSEGSAPGTSESATPESGPTSESATPESGGTSESATPEPSGPGSEPATSGSETPGSPAGTSAPPGSAPAG 288 8007 N-terminal XTEN 1 ASSPAGSPTSTESGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPE SGPGSTPAE SGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTEEGSPAGSPTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGTTSESATPESGPGSEPATSGSETGTSEPAGSAPGSTPEGSAPPEG 288 8008 C-terminal XTEN 1 PGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSE GSAPGTE STPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPG 864 8009 C-terminal XTEN 1 PGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSE GSAPGTE STPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPG 576 8010 N-terminal XTEN 2 SAGSPGSPAGSPTTEEGTSESATPESGPGTSTEEPSEGSAPGSPAGSPTTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPE SGPGSTPAE SGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPGSPTTEEGTSTEPEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSE PATSGSTE 1152 8011 C-terminal XTEN 3 SAGSPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSE PATSGSTE TPGSPAGSPTSTEEGTSESATP ESGPGTSTEPSEGSAPGTSTEEPSEGSAPGSPAGSPTTEEGTSTESE GSAPGTATE SPEGSAPGTSESATPESGPGTSTESE GSATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEEPSESAPGTSESATPESGPGTESAS 1152 8012 N-terminal XTEN 2 SASPE _ 864 8013 N-terminal XTEN 1 GSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSE SATSGSE 864 8014 N-terminal XTEN 1 SPAGSPTSTESGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPE SGPGSTPAESGSE TPGTSESATPESGPGTSTEPSEGSAPGSPGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSEGSPTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSEPSSEGSPEGSPEGSPEGSPEGSAPTEPSAGT 292 8015 C-terminal XTEN 1 PGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSE GSAPGTE STPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGEPEA 582 8016 C-terminal XTEN 1 TPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSE SATSGSE TPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESA 576 8017 C-terminal XTEN 1 GTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSE SASPE SGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGP 576 8018 C-terminal XTEN 1 GSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSE PATSGSTE TGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATS 576 8019 C-terminal XTEN 1 EGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSE SASPE SGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESAT 576 8020 N-terminal XTEN 1 ASSPAGSPTSTESGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPE SGPGSTPA ESGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTEEGSPAGSPTTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSEPATSGSETGTSEPAGSAPAGSPAGS 294

In some embodiments, the barcoded XTEN can be obtained by making one or more mutations to the universal XTEN according to one or more of the following criteria, such as any of the mutations listed in Table 3b : Sequence changes in the XTEN Drugs that minimize, minimize changes in amino acid composition in XTEN, substantially maintain the net charge of XTEN, substantially maintain (or improve) the low immunogenicity of XTEN, and substantially maintain (or improve) XTEN dynamic properties. In some embodiments, the XTEN sequence is at least 90%, at least 92%, at least 95%, at least 98%, at least 99%, or 100% identical to any of SEQ ID NOs: 601-659 listed in Table 3b sequence identity. In some embodiments, at least 90% (e.g., at least 92%, at least 95%, at least 98%, or at least 99%) but less than any of SEQ ID NOs: 601-659 listed in Table 3b XTEN sequences with 100% sequence identity are mutated by one or more of the corresponding sequences from Table 3b (e.g., less than 10, less than 8, less than 6, less than 5, less than 4, less than 3, less than 2 mutations) to obtain. In some embodiments, the one or more mutations comprise deletion of glutamic acid residues, insertion of glutamic acid residues, substitution of glutamic acid residues or substitution of glutamic acid residues, or any combination thereof. In some embodiments, wherein the XTEN sequence is different from any of the SEQ ID NOs: 601-659 listed in Table 3b , but at least 90% (e.g., at least 92%, at least 95%, at least 98%) identical thereto or at least 99%) sequence identity, at least 80%, at least 90%, at least 95%, at least 97%, or about 100% of the difference between the XTEN sequence and the corresponding sequence in Table 3b involves deletion of glutamic acid residues, glutamic acid residues, Insertion of amino acid residues, substitution of glutamic acid residues or substitution of glutamic acid residues or any combination thereof. In some of these embodiments, at least 80%, at least 90%, at least 95%, at least 97%, or about 100% of the difference between the XTEN sequence and the corresponding sequence of Table 3b involves substitution of glutamic acid residues or substitution of glutamic acid residues. amino acid residues or both. The term "first amino acid substitution" as used herein refers to the replacement of a second amino acid residue with a first amino acid, causing the second amino acid residue to be replaced at the substituted position in the resulting sequence . For example, "glutamate substitution" refers to the replacement of a non-glutamate residue (eg, serine (S)) with a glutamate (E) residue. As used herein, the term "substituting a first amino acid" refers to replacing a first amino acid residue with a second amino acid residue, resulting in the first amino acid residue at the substituted position in the resulting sequence replaced. For example, "substituted glutamic acid" refers to the replacement of a glutamic acid residue with a non-glutamic acid residue (eg, serine (S)). Table 3b. Exemplary Universal XTEN for Engineering into Barcoded XTEN(s) XTEN name amino acid sequence SEQ ID NO AE144 GSEPATSGSETPGTSESATPESGPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGSEPATSGSETPGSEPATSGSETPGSEPATSGSETPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPP 601 AE144_1A SPAGSPTTEEGTSESATPESGPGTSTEEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPG 602 AE144_2A TSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSEPSESATPESGPG 603 AE144_2B TSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSEPSESATPESGPG 604 AE144_3A SPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEEPSESAGTSTEPSEGSAPGTSTEEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPG 605 AE144_3B SPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEEPSESAGTSTEPSEGSAPGTSTEEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPG 606 AE144_4A TSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPG 607 AE144_4B TSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPG 608 AE144_5A TSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTTSTEEGSPAGSPTSTEEG 609 AE144_6B TSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPG 610 AE288_1 GTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSSEATPESGPGSPAGSPTTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGPSEPATSGSETPGSPAGSPTSTEEGSPTSTEPSSEPGTSEPG 611 AE288_2 GSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPGSPTTEEGTSTEEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAGPTSTEPSGPGSPAGSPTSTEEGSPAGSPTEEGSPAGSTPTE 612 AE576 613 AE624 MAEPAGSPTSTEEGTPGSGTASSSPGSSTPSGATGSPGASPGTSSTGSPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAP 614 AE864 615 AE865 GGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAP 616 AE866 PGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPG 617 AE1152 GSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPA GSPTSTEEGTSTEEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPA 618 AE144A STEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTTSTEEGSPAGSPTSTEEGS 619 AE144B SEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTTSTEEGSPAGSPTSTEEGTSTEPSEGSAPG 620 AE180A TSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSEPESAPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGSTEPSEGSAPGTSTEPSEGSAPGSEPATS 621 AE216A PESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSEPATSGSETPGTSESATS 622 AE252A ESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTTEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGSTEPSEGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSEPES 623 AE288A TPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTTEEGSPAGSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGTSEPATSGSETPGSPAGSSETSPTEEGPSTEEGPST 624 AE324A PESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATS 625 AE360A PESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESAT 626 AE396A PESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPS 627 AE432A EGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATS 628 AE468A EGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESAT 629 AE504A EGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPS 630 AE540A TPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEP 631 AE576A TPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESA 632 AE612A GSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESAT 633 AE648A PESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESAT 634 AE684A EGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATS 635 AE720A TSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTE 636 AE756A TSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSES 637 AE792A EGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPS 638 AE828A PESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESAT 639 AE869 GSPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGR 640 AE144_R1 SAGSPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTESASR 641 AE288_R1 SAGSPTGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTTSTEEGSPAGSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPPGTSEPATSGSETPGSEPATSGSETPGSTEPPSAGPSTEEEGTSTEPSEGSAPGTSPAGSSAPGSEPATS 642 AE432_R1 SAGSPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTESASR 643 AE576_R1 SAGSPTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPSASR 644 AE864_R1 SAGSPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTESASR 645 AE712 PGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEAHHH 646 AE864_R2 GSPGAGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTESASR 647 AE288_3 SPAGSPTSTEEGTSESATPESGPGTSTEEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSEGSPAGSPTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETGSPGSPTSESATPESGPSGSET 648 AE284 GTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGPSEPATSGSETPGSPAGSPTSTEEEGTSTEPSSEGTSTEPSPEG 649 AE292 SPAGSPTSTEEGTSESATPESGPGTSTEEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSEEGSPAGSSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSAPGTSAPGTSGSET 650 AE864_2 AGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGAAEPEA 651 AE867 GSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGAAEPEA 652 AE867_2 SPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPG 653 AE868 PGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGAAEPEA 654 AE144_7A GSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAP 655 AE292 SPAGSPTSTEEGTSESATPESGPGTSTEEPSEGSPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSAPGTSAPGTSGSET 656 AE293 PGSPAGSPTSTEEGTSESATPESGPGTSTEEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSEPESGPGSEPATSGSETPGSPTSEEGTSEPATSGSETPGSPAGSPTTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPTTEEGTSTEPSEGSAPGTSEPSEGSPGTSESATPESGPGTSTEPSEGSAPGTSEPSAPGTSPEGSEPAGTSA 657 AE300 PGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSEPESGPGSEPATSGSETPGSPAGSPTTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTTEEGTSTEPSEGSAPGTSEPSEGSPGTSESATPESGPGTSTEPSEGSAPGTSEPSEGPSGPGSEPATSGSETPGTSTEPSPAGTSAPGTSTEEGSAPGTSA 658 AE584 PGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGAAEPEA 659

In some embodiments, to construct the sequence of the barcoded XTEN, amino acid mutations are performed on XTENs of intermediate length relative to the XTENs of Table 3b and XTENs of longer length compared to the XTENs of Table 3b , such as wherein Add one or more 12-mer motifs from Table 1 to amino acid mutations at the N-terminal or C-terminal of the universal XTEN in Table 3b .

Additional examples of general XTEN sequences that can be used in accordance with the present invention are disclosed in US Patent Publication Nos. 2010/0239554 Al, 2010/0323956 Al, 2011/0046060 Al, 2011/0046061 Al, 2011/0077199 A1 or No. 2011/0172146 A1 or International Patent Publication No. WO 2010091122 A1, WO 2010144502 A2, WO 2010144508 A1, WO 2011028228 A1, WO 2011028229 A1, WO 2011028344 A2, WO 2014/011819 A2 or WO 2015/023891.

In some embodiments, a fused barcoded XTEN within the polypeptide chain adjacent to the N-terminus of the polypeptide chain ("N-terminal XTEN") can be linked at the N-terminus to HHHHHH (SEQ ID NO: 48) or HHHHHHHH (SEQ ID NO: 48) NO: 49) His tag for easy purification of fusion polypeptide. In some embodiments, a fusion barcoded XTEN within the polypeptide chain at the C-terminus of the polypeptide chain ("C-terminal XTEN") may comprise or be linked to the sequence EPEA at the C-terminus to facilitate purification of the fusion polypeptide. In some embodiments, the fusion polypeptide comprises both an N-terminal barcoded XTEN and a C-terminal barcoded XTEN, wherein the N-terminal barcoded XTEN is linked at the N-terminus to HHHHHH (SEQ ID NO: 48) or HHHHHHHH (SEQ ID NO: 48) ID NO: 49) His tag; and wherein the C-terminal barcoded XTEN is connected to the sequence EPEA at the C-terminus, thereby facilitating the purification of the fusion polypeptide by chromatography known in the art, for example reaching at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or at least 99% pure by chromatography including, but not limited to, IMAC chromatography, C-tagXL affinity matrices, and Other such methods, but not limited to those described in the Examples section below. protease digestion

Barcode fragments as described above or anywhere else herein are cleavably fused within the XTEN and are releasable (configured to release) from the XTEN following protease digestion of the polypeptide. In some embodiments, the protease is Glu-C protease. In some embodiments, the protease cleaves on the C-terminal side of a glutamic acid residue not followed by a proline. Those of ordinary skill in the art will appreciate that barcoded XTENs (XTENs that contain barcode fragment(s) within them) are designed to achieve high efficiency, precision and accuracy of protease digestion. For example, one of ordinary skill in the art will appreciate that adjacent Glu-Glu (EE) residues in the XTEN sequence may result in different cleavage patterns following Glu-C digestion. Thus, when Glu-C protease is used for barcode release, the barcoded XTEN or barcode fragment(s) may not contain any Glu-Glu(EE) sequences. Those skilled in the art will also understand that if the dipeptide Glu-Pro (EP) sequence is present in the fusion polypeptide, it may not be cleaved by Glu-C protease during the barcode release process. Structure configuration of BPXTEN

In some embodiments, a BPXTEN fusion protein comprises a single BP and a single XTEN. The BPXTEN can have at least the following configuration permutations, each configuration permutation listed in N-terminal to C-terminal orientation: BP-XTEN; XTEN-BP; BP-S-XTEN; and XTEN-S-BP.

In some embodiments, the BPXTEN comprises a C-terminal XTEN and optionally a spacer sequence (S) between the XTEN and BP (such as the spacer sequence (S) described herein, eg, in Table C). The BPXTEN can be represented by formula I (depicted from N-terminus to C-terminus): (BP)-(S) _x- (XTEN) ( I ), wherein BP is a biologically active protein as described below; S is optional including BP release A spacer sequence (such as a spacer sequence described herein, e.g., in Table C) of between 1 and about 50 amino acid residues for a segment (as described more fully below); x is 0 or 1 and the XTEN can be any XTEN as described above or anywhere else herein.

In some embodiments, the BPXTEN comprises an N-terminal XTEN and optionally a spacer sequence (S) between the XTEN and BP (such as the spacer sequence (S) described herein, eg, in Table C). The BPXTEN can be represented by formula II (depicted from N-terminus to C-terminus): (XTEN)-(S) _x- (BP) ( II ), wherein BP is a biologically active protein as described below; S is optionally including BP release A spacer sequence (such as a spacer sequence described herein, e.g., in Table C) of between 1 and about 50 amino acid residues for a segment (as described more fully below); x is 0 or 1 and the XTEN can be any XTEN as described above or anywhere else herein.

In some embodiments, the BPXTEN comprises both N-terminal XTEN and C-terminal XTEN. The BPXTEN (e.g., XPAT in Figures 1-2) can be represented by Formula III : (XTEN)-(S) _y- (BP)-(S) _z- (XTEN) ( III ) where BP is as described below Biologically active protein; S is a spacer sequence (such as described herein, e.g., in Table C) of between 1 and about 50 amino acid residues, optionally including a BP release segment (as described more fully below) spacer sequence); y is 0 or 1; z is 0 or 1; and the XTEN can be any XTEN as described above or anywhere else herein.

Bioactive Peptides

Bioactive proteins (BP) fused to XTEN (as described herein above or described anywhere else herein) comprising the sequences identified herein by the sequences of Tables 6a-6f , in particular the organisms disclosed below Active proteins (BP), and their corresponding nucleic acid and amino acid sequences are well known in the art. Descriptions and sequences of these BPs are available in databases such as Chemical Abstracts Service (e.g. CAS Registry), GenBank (GenBank), Universal Protein Resource (UniProt) and subscriptions such as GenSeq ( e.g. Derwent) Obtained from the public repository of the repository. The polynucleotide sequence may be the wild-type polynucleotide sequence encoding a given BP ( e.g. , full-length or mature), or in some cases, the sequence may be a variant of the wild-type polynucleotide sequence ( e.g., encoding a wild-type biological activity protein), wherein the DNA sequence of the polynucleotide has been optimized, e.g., for expression in a particular species; or a polynucleotide encoding a wild-type protein variant such as a site-directed mutant or an allogenic variant . The BPXTEN constructs encompassed by the invention were generated using methods known in the art and/or in conjunction with the guidelines and methods provided herein using wild-type or consensus cDNA sequences or codon-optimized variants of BP without sufficient familiarity with the subject matter. within the competence of the technician.

A BP for inclusion in a BPXTEN (a fusion polypeptide comprising at least one BP and at least one XTEN) may comprise any protein of biological, therapeutic, prophylactic or diagnostic interest or function, or suitable for mediating biological Any protein that activates or prevents or ameliorate a disease, disorder or condition. Of interest is the search for BPs with increased pharmacokinetic parameters, increased solubility, improved stability, activity masking, or some other enhanced medicinal property, or that increased terminal half-life would improve efficacy, safety, or lead to less frequent dosing and/or These BPs improved patient compliance. Accordingly, BPXTEN fusion protein compositions are prepared with various goals in mind, including by, for example, increasing in vivo exposure or prolonging the period of maintaining BPXTEN within the therapeutic window when administered to an individual, compared to BP not linked to XTEN. time to improve the therapeutic efficacy of bioactive compounds.

A BP may be a native full-length protein, or may be a fragment or sequence variant of a biologically active protein that retains at least a portion of the biological activity of the native protein.

In one embodiment, a BP incorporated into a composition of the invention may be a recombinant polypeptide having a sequence corresponding to a protein found in nature. In some embodiments, BPs may be sequence variants, fragments, homologues, and mimetics of the native sequence that retain at least a portion of the biological activity of the native BP. In a non-limiting example, a BP may exhibit at least about 80% sequence identity or alternatively 81%, 82%, 83%, 84%, 85%, 86%, 87% to a protein sequence identified herein %, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity. In another non-limiting example, a BP can be a bispecific sequence comprising a first binding domain and a second binding domain, wherein the first binding domain with specific binding affinity for a tumor-specific marker or target cell antigen is associated with The paired VL and VH sequences of the anti-CD3 antibodies identified herein by Table 6f exhibit at least about 80% sequence identity or alternatively 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity; and wherein to effector cells The second binding domain with specific binding affinity exhibits at least about 80% sequence identity or alternatively 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% sequence identity. In one embodiment, a BPXTEN fusion protein may comprise a single BP molecule linked to XTEN. In some embodiments, a BPXTEN can comprise a first BP and a second molecule of the same BP, resulting in a fusion protein comprising two BPs (eg, two glucagon molecules or two hGH molecules) linked to one or more XTENs.

In general, a BP will exhibit binding specificity for a given target (or a given number of targets) or exhibit another desired biological characteristic when used in vivo or when used in an in vitro assay. For example, a BP can be an agonist, receptor, ligand, antagonist, enzyme, antibody (eg, monospecific or bispecific), or hormone. Of great interest are BPs used or known to be useful in diseases or conditions, where the native BP has a relatively short terminal half-life, and enhanced pharmacokinetic parameters (which can optionally be released from the fusion protein by a cleavage spacer sequence) BP with less frequent dosing or enhanced pharmacology would permit. Also of interest are BPs with a narrow therapeutic window between the minimum effective dose or blood concentration (Cmin) and the maximum tolerated dose or blood concentration (Cmax). In such cases, linkage of the BP to a fusion protein comprising the selected XTEN sequence(s) can lead to improvements in these properties, making it more suitable for use as a therapeutic or prophylactic agent compared to BP not linked to XTEN.

BP encompassed by the compositions of the present invention may have utility in the treatment of various therapeutic classes or disease classes including, but not limited to, glucose and insulin disorders, metabolic disorders, cardiovascular diseases, coagulation and bleeding disorders, growth disorders or conditions , endocrine disorders, eye diseases, kidney diseases, liver diseases, tumorigenic conditions, inflammatory conditions, autoimmune conditions, etc.

"Anti-CD3" means monoclonal antibodies against the T cell surface protein CD3, species and sequence variants and fragments thereof, including OKT3 (also known as muromonab) and humanized anti-CD3 monoclonal antibodies (hOKT31 (Ala-Ala)) (KC Herold et al., New England Journal of Medicine 346:1692-1698. 2002). Anti-CD3 prevents T cell activation and proliferation by binding to the T cell receptor complex present on all differentiated T cells. The anti-CD3-containing fusion proteins of the present invention are particularly useful for slowing new onset type 1 diabetes, including the use of anti-CD3 as a therapeutic effector as well as a targeting moiety for the second therapeutic agent, BP, in the BPXTEN composition. The sequences of the variable regions and the production of anti-CD3 have been described in US Patent Nos. 5,885,573 and 6,491,916.

The BPs of the compositions of the present invention are not limited to natural full-length polypeptides, and also include recombinant versions as well as biologically and/or pharmacologically active variants or fragments thereof. For example, it is understood that various amino acid substitutions can be made in a GP to generate variants with respect to the biological activity or pharmacological properties of the BP without departing from the spirit of the invention. Examples of conservative substitutions for amino acids in a polypeptide sequence are shown in Table 5 . However, in embodiments of the BPXTEN in which the sequence identity of the BP is less than 100% compared to the specific sequence disclosed herein, the invention encompasses substitution of a given BP with any of the other 19 natural L-amino acids For a given amino acid residue, the given amino acid residue can be at any position within the sequence of the BP, including adjacent amino acid residues. If any of the substitutions result in an undesired change in biological activity, one of the alternative amino acids can be employed, and by the methods described herein or using the methods described in, for example, the U.S.A., the contents of which are incorporated by reference in their entirety. Any of the techniques and guidelines for conservative and non-conservative mutations in Patent No. 5,364,934 or evaluation of constructs using methods generally known to those skilled in the art. In addition, variants may also include, for example, polypeptides in which one or more amino acid residues have been added or deleted at the N- or C-terminus of the full-length native amino acid sequence of a BP that retains at least a portion of the biological activity of the native peptide.

Table 5: Exemplary Conservative Amino Acid Substitutions original residue Exemplary substitution Ala (A) val; leu; ile Arg (R) lys; gin; asn Asn (N) gin; his; lys; arg Asp (D) glu Cys (C) ser Gln (Q) asn Glu (E) asp Gly (G) pro His (H) asn: gin: Iys: arg xIle (I) leu; val; met; ala; phe: norleucine Leu (L) Norleucine: ile: val; met; ala: phe Lys (K) arg: gin: asn Met (M) leu; phe; ile Phe (F) leu: val: ile; ala Pro (P) gly Ser (S) thr Thr (T) ser Trp (W) tyr Tyr(Y) trp: phe: thr: ser Val (V) ile; leu; met; phe; ala; norleucine

In some embodiments, the BP incorporated into the BPXTEN fusion protein may have a sequence exhibiting at least about 80% sequence identity, alternatively at least about 81%, or about 82%, or about 83%, or about 84% , or about 85%, or about 86%, or about 87%, or about 88%, or about 89%, or about 90%, or about 91%, or about 92%, or about 93%, or about 94% , or about 95%, or about 96%, or about 97%, or about 98%, or about 99%, or about 99%, or 100% sequence identity. In some embodiments, the BP incorporated into the BPXTEN can be a bispecific sequence comprising a first binding domain and a second binding domain, wherein the first binding domain with specific binding affinity for a tumor-specific marker or target cell antigen Domains exhibit at least about 80% sequence identity or alternatively 81%, 82%, 83%, 84%, 85%, 86% to the paired VL and VH sequences of the anti-CD3 antibodies identified herein by Table 6f %, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity; and wherein to The second binding domain with specific binding affinity for the effector cell exhibits at least about 80% sequence identity or alternatively 81%, 82 with the paired VL and VH sequences of the anti-target cell antibodies identified herein by Table 6a %, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% sequence identity. The activity of the BPs of the preceding embodiments can be assessed using assays or measurement or determination parameters as described herein, and retain at least about 40%, or about 50%, or about 55%, or about 60% compared to the corresponding native BP sequence %, or about 70%, or about 80%, or about 90%, or about 95% or more of those sequences will be considered suitable for inclusion in the BPXTENs of the invention. BPs found to retain the appropriate level of activity may be linked to one or more of the XTEN polypeptides described above or anywhere else herein. In one embodiment, a BP found to retain activity at the appropriate level can be linked to a BP having at least about 80% sequence identity (e.g., at least about 81%, at least about 82%, at least about 83%) to a sequence from Tables 3a-3b . %, at least about 84%, at least about 85%, at least about 86%, at least about 87%, at least about 88%, at least about 89%, at least about 90%, at least about 91%, at least about 92%, at least about 93% %, at least about 94%, at least about 95%, at least about 96%, at least about 97%, at least about 98%, at least about 99%, or 100% sequence identity) or more XTEN polypeptides, thereby generating a chimeric fusion protein. T cell zygote

An additional structural configuration of BPXTEN relates to an XTENylated protease-activated T-cell engager ("XPAT"), wherein BP is a bispecific antibody (eg, a bispecific T-cell engager). In some embodiments, the XPAT composition comprises (1) a first portion comprising a first binding domain and a second binding domain and (2) a second portion comprising a release segment and (3) a third portion comprising a swelling portion. In some embodiments, the XPAT composition has the configuration of Formula Ia (depicted from N-terminus to C-terminus): (First part)-(Second part)-(Third part) ( Ia ) wherein the first part is comprising two scFv A bispecific, wherein the first binding domain has specific binding affinity for a tumor-specific marker or target cell antigen and the second binding domain has specific binding affinity for effector cells; the second part comprises a mammalian protease ( As described more fully below, the protease may be tumor-specific or antigen-specific, thereby activating) the cleaved release segment (RS); and the third portion is the swelling portion. In the foregoing embodiments, the first part of the binding domains may be in the following order: (VL-VH)1-(VL-VH)2, wherein "1" and "2" respectively represent the first binding domain and the second binding domain, or (VL-VH)1-(VH-VL)2 or (VH-VL)1-(VL-VH)2 or (VH-VL)1-(VH-VL)2, wherein the paired binding domains are obtained by Polypeptide linker ligation (as described more fully below). In one embodiment, the first portion VL and VH are set forth in Tables 6a-6f ; the RS is identified herein by the sequence group set forth in Tables 8a-8b (as described more fully below); and the expanded portion is XTEN ; albumin binding domain; albumin; IgG binding domain; polypeptide composed of proline, serine and alanine; fatty acid; Fc domain; polyethylene glycol (PEG), PLGA; or hydroxyethyl starch. When desired, the expanded portion is at least about 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, XTEN with 99% or 100% sequence identity. In the foregoing embodiments, the composition is a recombinant fusion protein. In some embodiments, the moieties are linked by chemical bonding.

In some embodiments, the XPAT composition has the configuration of Formula IIa (depicted from N-terminus to C-terminus): (third part)-(second part)-(first part) ( IIa ) wherein the first part is comprising two scFv A bispecific body wherein the first binding domain has specific binding affinity for a tumor-specific marker or target cell antigen and the second binding domain has specific binding affinity for effector cells; the second part comprises The release section (RS); and the third part is the expansion part. In the foregoing embodiments, the first part of the binding domains may be in the following order: (VL-VH)1-(VL-VH)2, wherein "1" and "2" respectively represent the first binding domain and the second binding domain, or (VL-VH)1-(VH-VL)2 or (VH-VL)1-(VL-VH)2 or (VH-VL)1-(VH-VL)2, wherein the paired binding domains are obtained by Polypeptide linker ligation, as described herein below. In one embodiment, the first portion VL and VH are identified in Tables 6a-6f ; RS is identified herein as the group of sequences set forth in Tables 8a-8b ; and the expansion portion is XTEN; albumin binding domain; albumin ; an IgG binding domain; a polypeptide composed of proline, serine, and alanine; a fatty acid; or an Fc domain. When desired, the expanded portion is at least about 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, XTEN with 99% or 100% sequence identity. In the foregoing embodiments, the composition is a recombinant fusion protein. In some embodiments, the moieties are linked by chemical bonding.

In some embodiments, the XPAT composition has the configuration of Formula IIIa (depicted from N-terminal to C-terminal): (fifth part)-(fourth part)-(first part)-(second part)-(third part ) ( IIIa ) wherein the first moiety is a bispecific comprising two scFvs, wherein the first binding domain has specific binding affinity for a tumor-specific marker or target cell antigen and the second binding domain has specific binding for effector cells Affinity; the second part comprises a release segment (RS) capable of being cleaved by mammalian proteases; the third part is a swelling part; the fourth part comprises a release segment capable of being cleaved by mammalian proteases which may be the same as or different from the second part (RS); and the fifth portion is an expansion portion which may or may not be the same as the third portion. In the foregoing embodiments, the first part of the binding domains may be in the following order: (VL-VH)1-(VL-VH)2, wherein "1" and "2" respectively represent the first binding domain and the second binding domain, or (VL-VH)1-(VH-VL)2 or (VH-VL)1-(VL-VH)2 or (VH-VL)1-(VH-VL)2, wherein the paired binding domains are obtained by Polypeptide linker ligation, as described herein below. In the preceding examples, the RSs were identified as the sequences set forth in Tables 8a-8b . In the foregoing embodiments, the expansion moiety is XTEN; an albumin binding domain; albumin; an IgG binding domain; a polypeptide composed of proline, serine, and alanine; a fatty acid; or an Fc domain. Where desired, the expanded portion is at least about 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97% identical to the sequence identified herein by the sequences set forth in Tables 3a-3b %, 98%, 99% or 100% sequence identity of the XTEN. In the foregoing embodiments, the composition is a recombinant fusion protein. In some embodiments, the moieties are linked by chemical bonding.

The compositions of the present invention, based on their design and specific components, advantageously provide bispecific therapeutics that are more selective, have a longer half-life, and are unhealthy once they are found to be related to the disease Protease cleavage associated with one or more target tissues results in less toxicity and fewer side effects, such that the compositions of the invention have an improved therapeutic index compared to bispecific antibody compositions known in the art. These compositions are useful in the treatment of certain diseases including, but not limited to, cancer. Those skilled in the art will appreciate that the compositions of the present invention achieve this reduction in non-specific interactions through a combination of mechanisms including: steric hindrance by positioning the binding domain to the large XTEN molecule; flexible non-structural The long flexible XTEN polypeptide characterized by XL is capable of oscillating and moving around the binding domain by being tethered to the composition, thereby providing a blocking-derived steric hindrance between the composition and the tissue or cell; Size Compared to the intact composition the ability to penetrate cells or tissues is reduced due to the large molecular mass (both the actual molecular weight of the XTEN and the large hydrodynamic radius due to the unstructured XTEN contribute). However, the composition is designed such that the bispecific binding occurs in proximity to the target tissue or cell carrying or secreting a protease capable of cleaving the RS, or when internalized into the target cell or tissue when the binding domain has bound the ligand. The domains are released from the XTEN host by the action of protease(s), thereby removing the steric barrier and freer to exert their pharmacological effects. Compositions of the invention are useful in the treatment of a variety of conditions in which selective delivery of therapeutic bispecific antibody compositions to cells, tissues or organs is desired. In one embodiment, the target tissue is a cancer, which can be a leukemia, a lymphoma, or a tumor of an organ or system. binding domain

The invention encompasses the use of single chain binding domains such as but not limited to Fv, Fab, Fab', Fab'-SH, F(ab')2, linear antibodies, single domain antibodies, single domain camelid antibodies , single-chain antibody molecules (scFv) and bifunctional antibodies capable of binding ligands or receptors associated with effector cells and antigens of diseased tissues or cells that are cancers, tumors or other malignant tissues. In some embodiments, the antigen-binding fragment ( AF ), such as the first antigen-binding fragment (AF1) or the second antigen-binding fragment (AF2), may (each independently) be a chimeric or humanized antigen-binding fragment. The antigen-binding fragment ( AF ), such as the first antigen-binding fragment (AF1) or the second antigen-binding fragment (AF2), can be (each independently) a Fv, Fab, Fab', Fab'-SH, a linear antibody, or a single chain Variable Fragment (scFv). Two antigen-binding fragments ( eg, a first antigen-binding fragment and a second antigen-binding fragment) can be configured as a (Fab')2 or single-chain diabody. In some embodiments, a bispecific comprises a first binding domain with binding specificity for a target cell marker and a second binding domain with binding specificity for an effector cell antigen. In some embodiments, the first binding domain and the second binding domain can be such as anticalin, adnectin (adnectin), phenomer (fynomer), affilin (affilin), affinity antibody, syntine (centyrin) or DARPin non-antibody backbone. In other embodiments, the binding domain of the tumor cell target is the variable domain of a T cell receptor of the MHC that has been engineered to bind a peptide fragment of a protein overexpressed by the tumor cell. In some embodiments, after considering the location of the target cathepsin and the presence of the same protease in healthy tissue that is not intended to be targeted and the presence of the target ligand in healthy tissue, but more of the ligand in unhealthy target tissue XPAT compositions were designed in order to provide a broad therapeutic window. "Therapeutic window" refers to the maximum difference between the minimum effective dose and the maximum tolerated dose of a given therapeutic composition. To help achieve a broad therapeutic window, the binding domain of the first part of the composition is shielded by access to the expanding moiety (e.g., XTEN), such that the full composition is more effective against the ligand than a composition that has been cleaved by a mammalian protease The binding affinity of one or both is reduced, thereby releasing the first moiety due to the masking effect of the swelling moiety.

In terms of single chain binding domains, Fv, if well established, is the smallest antibody fragment containing the complete antigen recognition and binding site; composed of a heavy chain variable domain (VH) and a light chain variable domain in non-covalent association Dimer composition of (VL). Within each VH and VL chain are three complementarity determining regions (CDRs) that interact to define the antigen-binding site on the surface of the VH-VL dimer; the six CDRs of the binding domain confer antibody or single-chain binding domains with antigen-binding specificity. In some cases, scFvs were generated, wherein each scFv had 3, 4 or 5 CHRs within each binding domain. The framework sequences flanking the CDRs have tertiary structure that is substantially conserved in native immunoglobulins across species, and framework residues (FRs) serve to hold the CDRs in their proper orientation. The constant domain is not required for binding function but helps stabilize VH-VL interactions. In some embodiments, the domains of the binding site of the polypeptide may be one of a pair of VH-VL, VH-VH, or VL-VL domains from the same or different immunoglobulins, however, it is generally preferred to use each domain from a parental antibody. Separate VH and VL chains make single-chain binding domains. The order of the VH and VL domains within a polypeptide chain is not limiting for the invention; a given domain order can generally be reversed without any loss of function, but it is understood that the VH and VL domains are arranged so that the antigen binding site can be properly to fold. Thus, the single chain binding domains of the bispecific scFv embodiments of the compositions of the invention can be in the following order: (VL-VH)1-(VL-VH)2, where "1" and "2" represent the first binding domain and a second binding domain, or (VL-VH)1-(VH-VL)2 or (VH-VL)1-(VL-VH)2 or (VH-VL)1-(VH-VL)2, wherein the paired binding domains are linked by a polypeptide linker, as described herein below.

Thus, the arrangement of binding domains in the exemplary bispecific single chain antibodies disclosed herein may be an arrangement in which the first binding domain is C-terminal to the second binding domain. The arrangement of the V chain can be VH (target cell surface antigen)-VL (target cell surface antigen)-VL (effector cell antigen)-VH (effector cell antigen), VH (target cell surface antigen)-VL (target cell surface antigen) )-VH (effector cell antigen)-VL (effector cell antigen), VL (target cell surface antigen)-VH (target cell surface antigen)-VL (effector cell antigen)-VH (effector cell antigen) or VL (target cell surface antigen)-VH (target cell surface antigen)-VH (effector cell antigen)-VL (effector cell antigen). For an arrangement where the second binding domain is N-terminal to the first binding domain, the following order is possible: VH (effector cell antigen)-VL (effector cell antigen)-VL (target cell surface antigen)-VH (target cell surface antigen) ), VH (effector cell antigen)-VL (effector cell antigen)-VH (target cell surface antigen)-VL (target cell surface antigen), VL (effector cell antigen)-VH (effector cell antigen)-VL (target cell Surface antigen)-VH (target cell surface antigen) or VL (effector cell antigen)-VH (effector cell antigen)-VH (target cell surface antigen)-VL (target cell surface antigen). As used herein, "the N-terminus" or "the C-terminus" and grammatical variants thereof indicate relative positions within the primary amino acid sequence, rather than at the absolute N-terminus or C-terminus of the bispecific single chain antibody. place. Thus, as a non-limiting example, a first binding domain "located C-terminal to the second binding domain" indicates that the first binding domain is located on the carboxyl side of the second binding domain within the bispecific single chain antibody and does not exclude The possibility of additional sequences such as a His-tag or another compound such as a radioisotope at the C-terminus of the bispecific single chain antibody.

In one embodiment, the chimeric polypeptide assembly composition comprises a first portion comprising a first binding domain and a second binding domain, wherein each of the binding domains is a scFv and wherein each scFv comprises a VL and a VH . In some embodiments, the chimeric polypeptide composition comprises a first portion comprising a first binding domain and a second binding domain, wherein the binding domains are in a bifunctional antibody configuration and wherein each domain comprises a VL domain and a VH.

It is contemplated that scFv embodiments of the XPAT compositions of the present invention comprise a first binding domain and a second binding domain, wherein the VL and VH domains are derived from a protein having binding specificity for a tumor-specific marker or target cell antigen and effector cell antigen, respectively. monoclonal antibody. In other cases, the first and second binding domains each comprise six CDRs derived from a monoclonal antibody having binding specificity for a cell marker of interest, such as a tumor-specific marker and Effector cell antigens. In other embodiments, the first binding domain and the second binding domain of the first part of the composition of the invention may have 3, 4 or 5 CHRs within each binding domain. In other embodiments, embodiments of the present invention comprise a first binding domain and a second binding domain, wherein each binding domain comprises a CDR-H1 region, a CDR-H2 region, a CDR-H3 region, a CDR-L1 region, a CDR-L2 region and CDR-H3 region, wherein each of these regions is derived from a monoclonal antibody capable of binding a tumor-specific marker or a target cell antigen and an effector cell antigen, respectively. In one embodiment, the present invention provides a chimeric polypeptide assembly composition, wherein the second binding domain comprises VH and VL regions derived from a monoclonal antibody capable of binding human CD3. In some embodiments, the invention provides chimeric polypeptide assembly compositions, wherein the scFv second binding domain comprises VH and VL regions, wherein each VH and VL region is paired with the VL and VL regions of the anti-CD3 antibody identified in Table 6a The VH sequence exhibits at least about 90%, or 91%, or 92%, or 93%, or 94%, or 95%, or 96%, or 97%, or 98%, or 99% identity or to such The paired VL and VH sequences are identical. In some embodiments, the second domain embodiments of the present invention comprise a CDR-H1 region, a CDR-H2 region, a CDR-H3 region, a CDR-L1 region, a CDR-L2 region, and a CDR-H3 region, wherein in these regions Each was derived from a monoclonal antibody identified herein as the antibody set forth in Table 6a . In the foregoing embodiments, the VH and/or VL domains can be configured as scFv, diabody, single domain antibody or single domain camelid antibody.

In other embodiments, the second domain of the compositions of the invention is derived from an anti-CD3 antibody identified herein as the antibody set forth in Table 6a . In one embodiment of the foregoing, the second domain of the composition of the invention comprises the paired VL and VH region sequences of the anti-CD3 antibodies identified herein as the antibody population set forth in Table 6a . In some embodiments, the invention provides chimeric polypeptide assembly compositions, wherein the second binding domain comprises VH and VL regions, wherein each VH and VL region exhibits the paired VL and VH sequences of the huUCHT1 anti-CD3 antibody of Table 6a at least about 90%, or 91%, or 92%, or 93%, or 94%, or 95%, or 96%, or 97%, or 98%, or 99% identical to or identical to the paired VL and The VH sequences are identical. In the foregoing embodiments, the VH and/or VL domains can be configured as scFv, part of a diabody, single domain antibody or single domain camelid antibody.

In other embodiments, the scFv of the first domain of the composition is derived from an anti-tumor cell antibody identified as the antibody set forth in Table 6f . In some embodiments, the present invention provides a chimeric polypeptide assembly composition, wherein the first binding domain comprises VH and VL regions, wherein each VH and VL region is paired with the paired VL and VL of the anti-tumor cell antibody identified in Table 6f The VH sequence exhibits at least about 90%, or 91%, or 92%, or 93%, or 94%, or 95%, or 96%, or 97%, or 98%, or 99% identity or to such The paired VL and VH sequences are identical. In one embodiment of the foregoing, the first domain of the described composition comprises the paired VL and VH region sequences of an anti-tumor cell antibody disclosed herein. In the foregoing embodiments, the VH and/or VL domains can be configured as scFv, part of a diabody, single domain antibody or single domain camelid antibody.

In some embodiments, the chimeric polypeptide composition comprises a first portion comprising a first binding domain and a second binding domain, wherein the binding domains are in a bifunctional antibody configuration and each of the binding domains comprises A VL domain and a VH domain. In one embodiment, the bifunctional antibody embodiment of the present invention comprises a first binding domain and a second binding domain, wherein the VL and VH domains are derived from tumor-specific markers or target cell antigens and effector cell antigens with binding specificities, respectively. Sexual monoclonal antibodies. In some embodiments, the bifunctional antibody of the present invention comprises a first binding domain and a second binding domain, wherein each binding domain comprises a CDR-H1 region, a CDR-H2 region, a CDR-H3 region, a CDR-L1 region, The CDR-L2 region and the CDR-H3 region, wherein each of these regions is derived from a monoclonal antibody capable of binding a tumor-specific marker or a target cell antigen and an effector cell antigen, respectively. It is contemplated that bifunctional antibody embodiments of the present invention comprise a first binding domain and a second binding domain, wherein the VL and VH domains are derived from a single antibody having binding specificity for a tumor-specific marker or target cell antigen and effector cell antigen, respectively. strain antibody. In some embodiments, the bifunctional antibody of the present invention comprises a first binding domain and a second binding domain, wherein each binding domain comprises a CDR-H1 region, a CDR-H2 region, a CDR-H3 region, a CDR-L1 region, The CDR-L2 region and the CDR-H3 region, wherein each of these regions is derived from a monoclonal antibody capable of binding a tumor-specific marker or a target cell antigen and an effector cell antigen, respectively. In one embodiment, the present invention provides a chimeric polypeptide assembly composition, wherein the second binding domain of the bifunctional antibody comprises paired VH and VL regions derived from a monoclonal antibody capable of binding human CD3. In some embodiments, the present invention provides a chimeric polypeptide assembly composition, wherein the second binding domain of the bifunctional antibody comprises VH and VL regions, wherein each VH and VL region is paired with the anti-CD3 antibody identified in Table 6a The VL and VH sequences exhibit at least about 90%, or 91%, or 92%, or 93%, or 94%, or 95%, or 96%, or 97%, or 98%, or 99% identity or to the The paired VL and VH sequences were consistent. In some embodiments, the present invention provides a chimeric polypeptide assembly composition, wherein the second binding domain of the bifunctional antibody comprises VH and VL regions, wherein each VH and VL region exhibits at least About 90%, or 91%, or 92%, or 93%, or 94%, or 95%, or 96%, or 97%, or 98%, or 99% identical or identical to the VL and VH sequences . In other embodiments, the second domain of the diabody of the composition is derived from an anti-CD3 antibody described herein. In some embodiments, the present invention provides a chimeric polypeptide assembly composition, wherein the first binding domain of the bifunctional antibody comprises VH and VL regions, wherein each VH and VL region is compatible with the VL of the anti-tumor cell antibody identified in Table 6f and a VH sequence exhibiting at least about 90%, or 91%, or 92%, or 93%, or 94%, or 95%, or 96%, or 97%, or 98%, or 99% identity or to such The VL and VH sequences are identical. In other embodiments, the first domain of the bifunctional antibody of the composition is derived from the anti-tumor cell antibodies described herein.

The methods of the present invention for measuring the binding affinity and/or other biological activities of the compositions of the present invention may be the methods disclosed herein or methods generally known in the art. For example, the binding affinity of a binding pair (e.g., antibody and antigen), expressed as a _Kd , can be determined using various suitable assays or as described in the Examples, including but not limited to radioactive binding assays; non-radioactive binding Assays such as fluorescence resonance energy transfer and surface plasmon resonance (SPR, Biacore); and enzyme-linked immunosorbent assay (ELISA), kinetic exclusion assay (KinExA®). An increase or decrease in binding affinity for a chimeric polypeptide assembly that has been cleaved to remove a swelling moiety, for example, compared to a chimeric polypeptide assembly linked to a swelling moiety can be measured by measuring the chimeric polypeptide assembly with and without swelling In some cases, the binding affinity to its target binding partner was determined.

The half-life measurement of the chimeric assembly of the present invention can be performed by various suitable methods. For example, the half-life of a substance can be determined by administering the substance to an individual and periodically sampling a biological sample (e.g., a biological fluid such as blood or plasma or ascites) to determine the concentration and/or amount of the substance in the sample over time to measure. Concentrations of substances in biological samples can be determined using various suitable methods including enzyme-linked immunosorbent assay (ELISA), immunoblot and chromatographic techniques including high pressure liquid chromatography and fast protein liquid chromatography . In some cases, a substance can be labeled with a detectable label, such as a radioactive or fluorescent label, which can be used to determine the concentration of the substance in a sample (eg, a blood sample or a plasma sample). The results are then used to determine various pharmacokinetic parameters, which can be performed using software packages such as the SoftMax Pro software or by manual calculations known in the art.

Additionally, the physicochemical properties of the chimeric polypeptide assembly composition can be measured to determine the extent of solubility, retention of structure and stability. An assay of the composition of the invention that allows determination of the binding characteristics of the binding domain for the ligand, including binding dissociation constants (Kd, _Kon and _Koff ), dissociation half-life of the ligand-receptor complex, is _performed As well as the activity ( _IC50 value) of the binding domain to inhibit the biological activity of the chelated ligand compared to the free ligand. The term " _IC50 " refers to the concentration required to inhibit a half-maximal biological response of a ligand agonist and is generally determined by competition binding assays. The term " _EC50 " refers to the concentration of an active substance required to achieve a half-maximal biological response and is generally determined by ELISA or cell-based assays, including the methods described in the examples herein. anti-CD3 binding domain

In some embodiments, the invention provides chimeric polypeptide total compositions comprising a binding domain of a first portion having binding affinity for T cells. In one embodiment, the binding domain of the second portion comprises VL and VH derived from a monoclonal antibody that binds CD3. In some embodiments, the binding domain comprises VL and VH derived from monoclonal antibodies directed against CD3ε and/or CD3δ. Illustrative, non-limiting examples of VL and VH sequences of monoclonal antibodies directed against CD3 are presented in Table 6a . In one embodiment, the invention provides an assembly of chimeric polypeptides comprising a binding domain with binding affinity for CD3 comprising the anti-CD3 VL and VH sequences set forth in Table 6a . In some embodiments, the invention provides chimeric polypeptide assemblies comprising a binding domain of a first portion having binding affinity for CD3ε, the binding domain comprising the anti-CD3ε VL and VH sequences set forth in Table 6a . In some embodiments, the invention provides chimeric polypeptide assembly compositions, wherein the scFv second binding domain of the first portion comprises VH and VL regions, wherein each VH and VL region is paired with the VL of the huUCHT1 anti-CD3 antibody of Table 6a and a VH sequence exhibiting at least about 90%, or 91%, or 92%, or 93%, or 94%, or 95%, or 96%, or 97%, or 98%, or 99% identity or to such The paired VL and VH sequences were identical. In some embodiments, the invention provides chimeric polypeptide assembly compositions comprising a binding domain having binding affinity for CD3, the binding domain comprising a CDR-L1 region, a CDR-L2 region, a CDR-L3 region, a CDR-H1 region , CDR-H2 region and CDR-H3 region, wherein each region is derived from the respective anti-CD3 VL and VH sequences set forth in Table 6a . In some embodiments, the invention provides chimeric polypeptide assembly compositions comprising a binding domain having binding affinity for CD3, the binding domain comprising a CDR-L1 region, a CDR-L2 region, a CDR-L3 region, a CDR-H1 region , CDR-H2 region and CDR-H3 region, wherein the CDR sequence is RASQDIRNYLN (SEQ ID NO: 50), YTSRLESQQGNTLPWT (SEQ ID NO: 78), GYSFTGYTMN (SEQ ID NO: 79), LINPYKGVST (SEQ ID NO: 80) and SGYYGDSDWYFDV (SEQ ID NO: 81).

The CD3 complex is a population of cell surface molecules that associate with the T cell antigen receptor (TCR) and acts on the cell surface expression of the TCR and the signaling transduction cascade that originates upon binding of a peptide:MHC ligand to the TCR. Normally, when an antigen binds to a T cell receptor, CD3 sends a signal across the cell membrane to the cytoplasm inside the T cell. This causes the activation of T cells, which divide rapidly to generate new T cells sensitive to the specific antigen exposed to the attacking TCR. The CD3 complex is composed of the CD3ε molecule and four other membrane-bound polypeptides (CD3-γ, CD3-δ and/or CD3-ζ). In humans, CD3-ε is encoded by the CD3E gene on chromosome 11. The intracellular domain of each of the CD3 chains contains immunoreceptor tyrosine-based activation motifs (ITAMs) that serve as nucleation points for the intracellular signaling machinery following T cell receptor engagement.

Various therapeutic strategies modulate T cell immunity by targeting TCR signaling, in particular anti-human CD3 monoclonal antibodies (MAbs) that are widely used clinically in immunosuppressive regimens. CD3-specific mouse mAb OKT3 is the first mAb authorized for use in humans (Sgro, C. Side-effects of a monoclonal antibody, muromonab CD3/orthoclone OKT3: bibliographic review. Toxicology 105:23-29, 1995) and is clinically Widely used as a transplant (Chatenoud, Clin. Transplant 7:422-430, (1993); Chatenoud, Nat. Rev. Immunol. 3:123-132 (2003); Kumar, Transplant. Proc. 30:1351-1352 (1998 )), immunosuppressants for type 1 diabetes and psoriasis. Importantly, anti-CD3 mAbs induce partial T cell signaling and clonal anergy (Smith, JA, Nonmitogenic Anti-CD3 Monoclonal Antibodies Deliver a Partial T Cell Receptor Signal and Induce Clonal Anergy J. Exp. Med. 185:1413- 1422 (1997)). OKT3 has been described in the literature as a T cell mitogen and a potent T cell killer (Wong, JT. The mechanism of anti-CD3 monoclonal antibodies. Mediation of cytolysis by inter-T cell bridging. Transplantation 50:683-689 (1990 )). Specifically, Wong's work showed that by bridging CD3 T cells and target cells, we can achieve targeted killing and that neither FcR-mediated ADCC nor complement fixation are required for bivalent anti-CD3 MAB to lyse target cells .

OKT3 exhibits both cell division and T-cell killing activity in a time-dependent manner; after early activation of T cells causing cytokine release, OKT3 later blocks all known T-cell functions upon further administration. Because of this later blockade of T cell function, OKT3 finds this widespread use as an immunosuppressant in regimens to reduce or even eliminate allograft tissue rejection. Other antibodies specific for the CD3 molecule are disclosed in Tunnacliffe, Int. Immunol. 1 (1989), 546-50, WO2005/118635 and WO2007/033230 describe anti-human monoclonal CD3ε antibodies, US Patent 5,821,337 describes murine anti-CD3 The VL and VH sequences of the monoclonal Ab UCHT1 (muxCD3, Shalaby et al., J. Exp. Med. 175, 217-225 (1992) and a humanized variant of this antibody (hu UCHT1 ), and US patent application 20120034228 disclosed Binding domains capable of binding to epitopes of human and non-chimpanzee primate CD3ε chains Table 6a: Anti-CD3 monoclonal antibodies and sequences Colony name Antibody name Target VH sequence SEQ ID NO. VL sequence SEQ ID NO. huOKT3 CD3 QVQLVQSGGGVVQPGRSLRLSCKAS GYTFTRYTMH WVRQAPGKGLEWIG YINPSRGYTNYNQKVKD RFTISRDNSKNTAFLQMDSLRPEDTGVYFCAR YYDDHYCLDY WGQGTPVTVSS 301 DIQMTQSPSSLSASVGDRVTITC SASSSVSYMN WYQQTPGKAPKRWIY DTSKLAS GVPSRFSGSGSGTDYTFTISSLQPEDIATYYC QQWSSNPFT FGQGTKLQITR 351 huUCHT1 CD3 EVQLVESGGGLVQPGGSLRLSCAAS GYSFTGYTMN WVRQAPGKGLEWVA LINPYKGVST YNQKFKDRFTISVDKSKNTAYLQMNSLRAEDTAVYYCAR SGYYGDSDWYFDV WGQGTLVTVSS 302 DIQMTQSPSSLSASVGDRVTITC RASQDIRNYLN WYQQKPGKAPKLLIY YTSRLES GVPSRFSGSGSGTDYTLTISSLQPEDFATYYC QQGNTLPWT FGQGTKVEIK 352 hu12F6 CD3 QVQLVQSGGGVVQPGRSLRLSCKAS GYTFTSYTMH WVRQAPGKGLEWIG YINPSSGYTKYNQKFKD RFTISADKSKSTAFLQMDSLRPEDTGVYFCAR WQDYDVYFDY WGQGTPVTVSS 303 DIQMTQSPSSLSASVGDRVTMTC RASSSVSYMH WYQQTPGKAPKPWIY ATSNLAS GVPSRFSGSGSGTDYTLTISSLQPEDIATYYC QQWSSNPPT FGQGTKLQITR 353 mOKT3 CD3 QVQLQQSGAELARPGASVKMSCKAS GYTFTRYTMH WVKQRPGQGLEWIG YINPSRGYTNYNQKFKD KATLTTDKSSSTAYMQLSLTSEDSAVYYCAR YYDDHYCLDY WGQGTTLTVSS 304 QIVLTQSPAIMSASPGEKVTMTC SASSSVSYMN WYQQKSGTSPKRWIY DTSKLAS GVPAHFRGSGSGTSYSLTISGMEAEDAATYYC QQWSSNPFT FGSGTKLEINR 354 MT103 blinatumomab CD3 DIKLQQSGAELARPGASVKMSCKTS GYTFTRYTMH WVKQRPGQGLEWIG YINPSRGYTNYNQKFKD KATLTTDKSSSTAYMQLSLTSEDSAVYYCAR YYDDHYCLDY WGQGTTLTVSS 305 DIQLTQSPAIMSASPGEKVTMTC RASSSVSYMN WYQQKSGTSPKRWIY DTSKVAS GVPYRFSGSGSGTSYSLTISSMEAEDAATYYC QQWSSNPLT FGAGTKLELK 355 MT110 Solitomab CD3 DVQLVQSGAEVKKPGASVKVSCKAS GYTFTRYTMH WVRQAPGQGLEWIG YINPSRGYTNYADSVKG RFTITTDKSTSTAYMELSSLRSEDTATYYCAR YYDDHYCLDY WGQGTTVTVSS 306 DIVLTQSPATLSSLSPGERATLSC RASQSVSYMN WYQQKPGKAPKRWIY DTSKVAS GVPARFSGSGSGTDYSLTINSLEAEDAATYYC QQWSSNPLT FGGGTKVEIK 356 CD3.7 CD3 EVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSS 307 QTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGYYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCALWYSNRWVFGGGTKLTVL 357 CD3.8 CD3 EVQLVESGGGLVQPGGSLRLSCAASGFTFNTYAMNWVRQAPGKGLEWVGRIRSKYNNYATYYADSVKGRFTISRDDSKNTLYLQMNSLRAEDTAVYYCVRHGNFGNSYVSWFAYWGQGTLVTVSS 308 QAVVTQEPSLTVSPGGTVTLTCGSSTGAVTTSNYANWVQQKPGQAPRGLIGGTNKRAPGVPARFSGSLLGGKAALTLSGAQPEDEAEYYCALWYSNLWVFGGGTKLTVL 358 CD3.9 CD3 EVQLLESGGGLVQPGGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYVSWFAYWGQGTLVTVSS 309 ELVVTQEPSLTVSPGGTVTLTCRSSTGAVTTSNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCALWYSNLWVVFGGGTKLTVL 359 CD3.10 CD3 EVKLLESGGGLVQPKGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSQSILYLQMNNLKTEDTAMYYCVRHGNFGNSYVSWFAYWGQGTLVTVSS 310 QAVVTQESALTTSPGETVTLTCRSSTGAVTTSNYANWVQEKPDHLFTGLIGGTNKRAPGVPARFSGSLIGDKAALTITGAQTEDEAIYFCALWYSNLWVFGGGTKLTVL 360 *If the underlined sequence is present, it is the CDR CD3 cell antigen-binding fragment within the VL and VH

In some embodiments, the invention relates to antigen-binding fragments (AF1 ) having specific binding affinity for effector cell antigens, which AF1 may be incorporated into any of the embodiments of compositions of the invention described herein. In some cases, effector cell antigens are expressed on the surface of the following effector cells: plasma cells, T cells, B cells, interleukin-induced killer cells (CIK cells), mast cells, dendritic cells, regulatory T cells cells (RegT cells), helper T cells, myeloid cells or NK cells.

Various AF1 binding effector cell antigens are particularly useful for pairing with binding affinity for the HER2 antigen with antigen-binding fragments associated with diseased cells or tissues in a composition format in order to achieve cell killing of diseased cells or tissues. Binding specificity can be determined by complementarity determining regions or CDRs, such as light chain CDRs or heavy chain CDRs. In many cases, binding specificity is determined by light chain CDRs and heavy chain CDRs. A given combination of heavy chain CDRs and light chain CDRs provides a given binding pocket that confers higher affinity and/or specificity for the effector cell antigen compared to other reference antigens. The resulting bispecific composition having a first antigen-binding fragment (AF1) against HER2 linked by a short flexible peptide linker to a second antigen-binding fragment (AF2) with binding specificity for an effector cell antigen is bispecific. Specific, wherein each antigen-binding fragment has specific binding affinity for its respective ligand. It will be appreciated that in these compositions AF2 targeting HER2 of diseased tissue is used in combination with AF1 targeting effector cell markers in order to bring effector cells in close proximity to cells of diseased tissue in order to achieve cytolysis of cells of diseased tissue. In addition, AF1 and AF2 are incorporated into specifically designed polypeptides comprising a cleavable release segment and XTEN in order to confer prodrug characteristics on compositions by having in close proximity one or both of the release segment sequences. In diseased tissues, proteases that cleave the released segment in multiple locations are activated by releasing fusion AF1 and AF2 after cleavage of the released segment.

In one embodiment, AF1 of a composition of the invention has binding affinity for an effector cell antigen expressed on the surface of a T cell. In some embodiments, AF1 of the compositions of the invention has binding affinity for CD3. In some embodiments, AF1 of the compositions of the invention has binding affinity for a member of the CD3 complex that includes all known CD3 subunits of the CD3 complex, either alone or in independent combination; for example, CD3ε, CD3δ, CD3γ and CD3ζ. In some embodiments, AF1 has binding affinity for CD3ε, CD3δ, CD3γ, or CD3ζ.

The source of antigen-binding fragments encompassed by the invention can be derived from naturally occurring antibodies or fragments thereof, non-naturally occurring antibodies or fragments thereof, humanized antibodies or fragments thereof, synthetic antibodies or fragments thereof, hybrid antibodies or fragments thereof, or engineered Engineered antibodies or fragments thereof. Methods for generating antibodies against a given marker of interest are well known in the art. For example, monoclonal antibodies can be made using the fusionoma method first described by Kohler et al., Nature, 256:495 (1975), or can be made by recombinant DNA methods (US Patent No. 4,816,567). The structure of antibodies and their fragments, heavy and light chain variable regions (VH and VL), single chain variable regions (scFv), complementarity determining regions (CDRs) and domain antibodies (dAbs) of antibodies is well understood. Methods for generating polypeptides possessing the desired antigen-binding fragment with binding affinity for a given antigen are known in the art.

It is understood that the term "antigen-binding fragment" as used in the composition embodiments disclosed herein is intended to include a portion or fragment of an antibody that retains the ability to bind an antigen as a ligand for the corresponding intact antibody. In these embodiments, the antigen-binding fragment can be, but not limited to, the CDRs and intervening framework regions, variable regions or hypervariable regions, variable fragments (Fv) of light chains and/or heavy chains (VL, VH) of antibodies. , Fab' fragment, F(ab')2 fragment, Fab fragment, single chain antibody (scAb), VHH camelid antibody, single chain variable fragment (scFv), linear antibody, single domain antibody, complementarity determining region (CDR), Domain antibodies (dAbs), single domain heavy chain immunoglobulins of the BHH or BNAR type, single domain light chain immunoglobulins or other polypeptides known in the art that contain fragments of antibodies capable of binding antigen. Antigen-binding fragments with CDR-H and CDR-L can be configured in the N-terminal to C-terminal (CDR-H)-(CDR-L) or (CDR-H)-(CDR-L) orientation. The VL and VH of the two antigen-binding fragments can also be configured in a single chain diabody configuration; that is, the VL and VH of AF1 and AF2 are configured with linkers of appropriate length to allow for arrangement as a diabody.

Various CD3-binding AF1s of the invention have been specifically modified to enhance their stability in the polypeptide embodiments described herein. Protein aggregation of antibodies continues to be a significant problem in their developability and remains a major focus area in antibody production. Antibody aggregation can be triggered by partially unfolding its domains, causing monomer-monomer association, followed by nucleation and aggregate growth. Although the aggregation propensity of antibodies and antibody-based proteins can be influenced by external experimental conditions, it is largely determined by the intrinsic antibody properties as determined by their sequence and structure. While it is well known that proteins are only slightly stable in their folded state, it is generally less well understood that most proteins are inherently prone to aggregation in their unfolded or partially unfolded state, and the resulting aggregates can be extremely stable and long-lived. Reduced aggregation propensity has also been shown to accompany increased expressiveness, demonstrating that reduced protein aggregation is beneficial throughout development and may lead to more efficient pathways for clinical studies. For therapeutic proteins, aggregates are a significant risk factor for adverse immune responses in patients and can form through a variety of mechanisms. Controlling aggregation can improve protein stability, manufacturability, wear rate, safety, formulation, potency, immunogenicity, and solubility. Intrinsic properties of proteins such as size, hydrophobicity, electrostatics, and charge distribution play an important role in protein solubilization. Low solubility of therapeutic proteins due to surface hydrophobicity has been shown to make formulation development more difficult and can lead to poor in vivo biodistribution, undesired pharmacokinetic behavior and immunogenicity. Reducing the overall surface hydrophobicity of candidate monoclonal antibodies can also provide benefits and cost savings associated with purification and dosing regimens. Individual amino acids can be identified by structural analysis as contributing to the aggregation potential in the antibody, and can be located in the CDRs as well as in the framework regions. In particular, residues can be predicted to be at high risk of causing hydrophobicity problems in a given antibody. In one embodiment, the present invention provides AF1 capable of specifically binding CD3, wherein AF1 has an amino acid substitution of at least one hydrophobic amino acid in the framework region relative to the parental antibody or antibody fragment, wherein the hydrophobic The amino acid is isoleucine, leucine or methionine. In some embodiments, CD3 AF1 has an amino acid substitution of at least two hydrophobic amino acids in one or more framework regions, wherein the hydrophobic amino acid is isoleucine, leucine, or methionine acid.

The isoelectric point (pi) is the pH at which an antibody or antibody fragment has no net charge. If the pH is below the pi of the antibody or antibody fragment, it will have a net positive charge. A larger positive charge tends to be associated with increased blood clearance and tissue retention, generally with a shorter half-life. If the pH is greater than the pi of the antibody or antibody fragment, it will have a negative charge. Negative charges generally result in reduced tissue absorption and longer half-lives. Manipulation of this charge is possible via mutation of framework residues. These considerations informed the sequence design of AF1 of the embodiments described herein, in which individual amino acid substitutions were made relative to the parent antibody used as a starting point. The isoelectric point of a polypeptide can be determined mathematically (eg, computationally) or experimentally in an in vitro assay. The isoelectric point (pi) is the pH at which a protein has zero net charge, and can be calculated using the charge of a particular amino acid in the protein sequence. The estimate of charge is called the acid dissociation constant or pKa value and is used to calculate pi. pi can be focused by means such as capillary isoelectric focusing ( see Datta-Mannan, A. et al. The interplay of non-specific binding, target-mediated clearance and FcRn interactions on the pharmacokinetics of humanized antibodies. mAbs 7:1084 (2015); Li , B. et al. Framework selection can influence pharmacokinetics of a humanized therapeutic antibody through differences in molecule charge. mAbs 6, 1255-1264 (2014)) or other methods known in the art to determine in vitro. In some embodiments, the isoelectric points of AF1 and AF2 are designed to be within a specific range of each other, thereby promoting stability.

In one embodiment, the invention provides an antigen-binding fragment (e.g., AF1 or AF2) for use in any of the polypeptide embodiments described herein, the antigen-binding fragment comprising CDR-L and CDR-H (see Table 6b ), wherein the antigen binding fragment (eg AF1 or AF2) (a) specifically binds to the cluster of differentiation 3 T cell receptor (CD3); and (b) comprises an amine group having SEQ ID NO: 8 , 9 and 10 , respectively CDR-H1, CDR-H2 and CDR-H3 of the acid sequence. In some embodiments, the CDR-H1 and CDR-H2 of the antigen-binding fragment (AF) may comprise the amino acid sequences of SEQ ID NO: 8 and 9 , respectively. In some embodiments, the invention provides an antigen-binding fragment (eg, AF1 or AF2) for use in any of the polypeptide embodiments described herein, the antigen-binding fragment comprising CDR-L and CDR-H, wherein the antigen The binding fragment (such as AF1 or AF2) (a) specifically binds to the cluster of differentiation 3 T cell receptor (CD3); (b) comprises CDR-H1 having the amino acid sequences of SEQ ID NO: 8 , 9 and 10 , respectively , CDR-H2 and CDR-H3. Antigen-binding fragments (such as AF1 or AF2) may comprise a CDR-L, wherein the CDR-L comprises CDR-L1 having the amino acid sequence of SEQ ID NO: 1 or 2 , having the amino acid of SEQ ID NO: 4 or 5 CDR-L2 having the sequence and CDR-L3 having the amino acid sequence of SEQ ID NO:6 . In some embodiments, where the peptide comprises an antigen-binding fragment (AF) comprising CDR-L1, CDR-L2, and CDR-L3 (eg, AF1 or AF2), the CDR-L1 of the AF may comprise SEQ ID The amino acid sequence of NO: 1 or 2 ; the CDR-L2 of AF may comprise the amino acid sequence of SEQ ID NO: 4 or 5 ; and the CDR-L3 of AF may comprise the amino acid of SEQ ID NO: 6 sequence. In some embodiments, where the peptide comprises an antigen-binding fragment (AF) comprising CDR-L1, CDR-L2, and CDR-L3 (eg, AF1 or AF2), the CDR-L1 of the AF may comprise SEQ ID The amino acid sequence of NO: 1 ; the CDR-L2 of AF may comprise the amino acid sequence of SEQ ID NO: 4 or 5 ; and the CDR-L3 of AF may comprise the amino acid sequence of SEQ ID NO: 6 . In some embodiments, where the peptide comprises an antigen-binding fragment (AF) comprising CDR-L1, CDR-L2, and CDR-L3 (eg, AF1 or AF2), the CDR-L1 of the AF may comprise SEQ ID The amino acid sequence of NO: 2 ; the CDR-L2 of AF may comprise the amino acid sequence of SEQ ID NO: 4 or 5 ; and the CDR-L3 of AF may comprise the amino acid sequence of SEQ ID NO: 6 . In some embodiments, where the peptide comprises an antigen-binding fragment (AF) comprising CDR-L1, CDR-L2, and CDR-L3 (eg, AF1 or AF2), the CDR-L1 of the AF may comprise SEQ ID The amino acid sequence of NO: 1 ; the CDR-L2 of AF may comprise the amino acid sequence of SEQ ID NO: 4 ; and the CDR-L3 of AF may comprise the amino acid sequence of SEQ ID NO: 6 . In some embodiments, where the peptide comprises an antigen-binding fragment (AF) comprising CDR-L1, CDR-L2, and CDR-L3 (eg, AF1 or AF2), the CDR-L1 of the AF may comprise SEQ ID The amino acid sequence of NO: 2 ; the CDR-L2 of AF may comprise the amino acid sequence of SEQ ID NO: 5 ; and the CDR-L3 of AF may comprise the amino acid sequence of SEQ ID NO: 6 .

In some embodiments, the foregoing antigen-binding fragment (AF) (eg, AF1 or AF2) embodiments of the preceding paragraph further comprise a light chain framework region (FR-L) and a heavy chain framework region (FR-H) (see Table 6c ) , wherein the antigen-binding fragment (AF) may comprise: exhibiting at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94% of the amino acid sequence of SEQ ID NO:51 , 95%, 96%, 97%, 98%, 99% sequence identity or FR-L1 consistent with the amino acid sequence, exhibiting at least 86%, 87%, and the amino acid sequence of SEQ ID NO:52 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence identity or FR-L2 identical to the amino acid sequence , exhibits at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95% of the amino acid sequence of any one of SEQ ID NO: 53-56 , 96%, 97%, 98%, 99% sequence identity or FR-L3 identical to the amino acid sequence, and the amino acid sequence of SEQ ID NO: 59 exhibiting at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence identity or FR-L4 identical to the amino acid sequence. The antigen-binding fragment (AF) may comprise: exhibiting at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95% of the amino acid sequence of SEQ ID NO:51 %, 96%, 97%, 98%, 99% sequence identity or FR-L1 consistent with the amino acid sequence, exhibiting at least 86%, 87%, 88% with the amino acid sequence of SEQ ID NO:52 , 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence identity or FR-L2 consistent with the amino acid sequence, and The amino acid sequence of SEQ ID NO: 53 exhibits at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% , 99% sequence identity or FR-L3 identical to the amino acid sequence, and the amino acid sequence of SEQ ID NO: 59 exhibiting at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence identity or FR-L4 identical to the amino acid sequence. The antigen-binding fragment (AF) may comprise: exhibiting at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95% of the amino acid sequence of SEQ ID NO:51 %, 96%, 97%, 98%, 99% sequence identity or FR-L1 consistent with the amino acid sequence, exhibiting at least 86%, 87%, 88% with the amino acid sequence of SEQ ID NO:52 , 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence identity or FR-L2 consistent with the amino acid sequence, and The amino acid sequence of SEQ ID NO: 54 exhibits at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% , 99% sequence identity or FR-L3 identical to the amino acid sequence, and the amino acid sequence of SEQ ID NO: 59 exhibiting at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence identity or FR-L4 identical to the amino acid sequence. The antigen-binding fragment (AF) may comprise: exhibiting at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95% of the amino acid sequence of SEQ ID NO:51 %, 96%, 97%, 98%, 99% sequence identity or FR-L1 consistent with the amino acid sequence, exhibiting at least 86%, 87%, 88% with the amino acid sequence of SEQ ID NO:52 , 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence identity or FR-L2 consistent with the amino acid sequence, and The amino acid sequence of SEQ ID NO: 55 exhibits at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% , 99% sequence identity or FR-L3 identical to the amino acid sequence, and the amino acid sequence of SEQ ID NO: 59 exhibiting at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence identity or FR-L4 identical to the amino acid sequence. The antigen-binding fragment (AF) may comprise: exhibiting at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95% of the amino acid sequence of SEQ ID NO:51 %, 96%, 97%, 98%, 99% sequence identity or FR-L1 consistent with the amino acid sequence, exhibiting at least 86%, 87%, 88% with the amino acid sequence of SEQ ID NO:52 , 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence identity or FR-L2 consistent with the amino acid sequence, and The amino acid sequence of SEQ ID NO: 56 exhibits at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% , 99% sequence identity or FR-L3 identical to the amino acid sequence, and the amino acid sequence of SEQ ID NO: 59 exhibiting at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence identity or FR-L4 identical to the amino acid sequence. An antigen-binding fragment (AF) may comprise : exhibiting at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence identity or FR-H1 consistent with the amino acid sequence, and the amino acid sequence of SEQ ID NO: 64 exhibit at least 86 %, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence identity or with the amino acid sequence FR-H2, exhibits at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95% identity with the amino acid sequence of SEQ ID NO: 65 or 66 , 96%, 97%, 98%, 99% sequence identity or FR-H3 consistent with the amino acid sequence and the amino acid sequence of SEQ ID NO: 67 exhibiting at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence identity or FR-H4 identical to the amino acid sequence. The antigen-binding fragment (AF) may comprise: exhibiting at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95% of the amino acid sequence of SEQ ID NO: 60 %, 96%, 97%, 98%, 99% sequence identity or FR-H1 identical to the amino acid sequence, and the amino acid sequence of SEQ ID NO: 64 exhibit at least 86%, 87%, 88% , 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence identity or FR-H2 consistent with the amino acid sequence, and The amino acid sequence of SEQ ID NO: 65 exhibits at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% , 99% sequence identity or FR-H3 identical to the amino acid sequence and the amino acid sequence of SEQ ID NO: 67 exhibiting at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence identity or FR-H4 identical to the amino acid sequence. The antigen-binding fragment (AF) may comprise: exhibiting at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95% of the amino acid sequence of SEQ ID NO: 61 %, 96%, 97%, 98%, 99% sequence identity or FR-H1 identical to the amino acid sequence, and the amino acid sequence of SEQ ID NO: 64 exhibit at least 86%, 87%, 88% , 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence identity or FR-H2 consistent with the amino acid sequence, and The amino acid sequence of SEQ ID NO: 65 exhibits at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% , 99% sequence identity or FR-H3 identical to the amino acid sequence and the amino acid sequence of SEQ ID NO: 67 exhibiting at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence identity or FR-H4 identical to the amino acid sequence. An antigen-binding fragment (AF) (e.g., AF1 or AF2) for use in any of the polypeptide embodiments described herein may comprise a light chain framework region (FR-L) and a heavy chain framework region (FR-H) , wherein AF may comprise: exhibiting at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96% of the amino acid sequence of SEQ ID NO: 51 %, 97%, 98%, 99% sequence identity or FR-L1 identical to the amino acid sequence, exhibiting at least 86%, 87%, 88% , 89% with the amino acid sequence of SEQ ID NO: 52 , 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence identity or FR-L2 consistent with the amino acid sequence, and SEQ ID NO : The amino acid sequence of any one of 53-56 exhibits at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97% %, 98%, 99% sequence identity or FR-L3 identical to the amino acid sequence, exhibits at least 86%, 87%, 88%, 89%, 90% with the amino acid sequence of SEQ ID NO: 59 , 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence identity or FR-L4 consistent with the amino acid sequence; and SEQ ID NO: 60 or The amino acid sequence of 61 exhibits at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence Identity or FR-H1 identical to the amino acid sequence exhibits at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93% of the amino acid sequence of SEQ ID NO: 64 %, 94%, 95%, 96%, 97%, 98%, 99% sequence identity or FR-H2 consistent with the amino acid sequence, exhibiting at least 86% with the amino acid sequence of SEQ ID NO: 65 , 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence identity or identical to the amino acid sequence The amino acid sequence of FR-H3 and SEQ ID NO: 67 exhibits at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96% , 97%, 98%, 99% sequence identity or FR-H4 identical to the amino acid sequence. AF may comprise : exhibiting at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence identity or FR-L1 identical to the amino acid sequence exhibits at least 86%, 87%, 88%, 89%, 90% with the amino acid sequence of SEQ ID NO: 52 %, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence identity or FR-L2 consistent with the amino acid sequence, and SEQ ID NO: 53 The amino acid sequence exhibits at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence identity or FR-L3 identical to the amino acid sequence, exhibiting at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93% of the amino acid sequence of SEQ ID NO: 59 , 94%, 95%, 96%, 97%, 98%, 99% sequence identity or FR-L4 consistent with the amino acid sequence; and the amino acid sequence of SEQ ID NO: 60 exhibits at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence identity or whichever is identical to the amino acid sequence FR-H1, and the amino acid sequence of SEQ ID NO: 64 exhibit at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence identity or FR-H2 identical to the amino acid sequence exhibits at least 86%, 87%, 88%, 89%, 90% with the amino acid sequence of SEQ ID NO: 65 %, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence identity or FR-H3 consistent with the amino acid sequence and SEQ ID NO: 67 The amino acid sequence exhibits at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence identity or FR-H4 consistent with the amino acid sequence. AF may comprise : exhibiting at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence identity or FR-L1 identical to the amino acid sequence exhibits at least 86%, 87%, 88%, 89%, 90% with the amino acid sequence of SEQ ID NO: 52 %, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence identity or FR-L2 consistent with the amino acid sequence, and SEQ ID NO: 54 The amino acid sequence exhibits at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence identity or FR-L3 identical to the amino acid sequence, exhibiting at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93% of the amino acid sequence of SEQ ID NO: 59 , 94%, 95%, 96%, 97%, 98%, 99% sequence identity or FR-L4 consistent with the amino acid sequence; and the amino acid sequence of SEQ ID NO: 61 exhibits at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence identity or whichever is identical to the amino acid sequence FR-H1, and the amino acid sequence of SEQ ID NO: 64 exhibit at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence identity or FR-H2 identical to the amino acid sequence exhibits at least 86%, 87%, 88%, 89%, 90% with the amino acid sequence of SEQ ID NO: 65 %, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence identity or FR-H3 consistent with the amino acid sequence and SEQ ID NO: 67 The amino acid sequence exhibits at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence identity or FR-H4 consistent with the amino acid sequence. AF may comprise : exhibiting at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence identity or FR-L1 identical to the amino acid sequence exhibits at least 86%, 87%, 88%, 89%, 90% with the amino acid sequence of SEQ ID NO: 52 %, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence identity or FR-L2 consistent with the amino acid sequence, and SEQ ID NO: 55 The amino acid sequence exhibits at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence identity or FR-L3 identical to the amino acid sequence, exhibiting at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93% of the amino acid sequence of SEQ ID NO: 59 , 94%, 95%, 96%, 97%, 98%, 99% sequence identity or FR-L4 consistent with the amino acid sequence; and the amino acid sequence of SEQ ID NO: 61 exhibits at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence identity or whichever is identical to the amino acid sequence FR-H1, and the amino acid sequence of SEQ ID NO: 64 exhibit at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence identity or FR-H2 identical to the amino acid sequence exhibits at least 86%, 87%, 88%, 89%, 90% with the amino acid sequence of SEQ ID NO: 65 %, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence identity or FR-H3 consistent with the amino acid sequence and SEQ ID NO: 67 The amino acid sequence exhibits at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence identity or FR-H4 consistent with the amino acid sequence. AF may comprise : exhibiting at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence identity or FR-L1 identical to the amino acid sequence, exhibiting at least 86%, 87%, 88%, 89% , 90% with the amino acid sequence of SEQ ID NO: 52 %, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence identity or FR-L2 consistent with the amino acid sequence, and SEQ ID NO: 56 The amino acid sequence exhibits at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence identity or FR-L3 identical to the amino acid sequence, exhibiting at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93% of the amino acid sequence of SEQ ID NO: 59 , 94%, 95%, 96%, 97%, 98%, 99% sequence identity or FR-L4 consistent with the amino acid sequence; and the amino acid sequence of SEQ ID NO: 61 exhibits at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence identity or whichever is identical to the amino acid sequence FR-H1, and the amino acid sequence of SEQ ID NO: 64 exhibit at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence identity or FR-H2 identical to the amino acid sequence exhibits at least 86%, 87%, 88%, 89%, 90% with the amino acid sequence of SEQ ID NO: 65 %, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence identity or FR-H3 consistent with the amino acid sequence and SEQ ID NO: 67 The amino acid sequence exhibits at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence identity or FR-H4 consistent with the amino acid sequence.

In some embodiments, the invention provides an antigen-binding fragment (AF) (e.g., AF1 or AF2) for use in any one of the polypeptide embodiments described herein, wherein the AF comprises the same sequence as SEQ ID NO: 102 of Table 6d Or the amino acid sequence of SEQ ID NO: 105 has at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence identity or with the amino acid sequence The variable heavy chain (VH) amino acid sequence consistent with the acid sequence. In some embodiments, the invention provides an AF for use in any one of the polypeptide embodiments described herein, wherein the AF comprises any of SEQ ID NO: 101 , 103 , 104 , 106 or 107 of Table 6d The amino acid sequence of one has at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence identity or is identical to the amino acid sequence Variable light chain (VL) amino acid sequence. In some embodiments, the invention provides an antigen-binding fragment (e.g., AF1 or AF2) for use in any one of the polypeptide embodiments described herein, wherein AF may comprise the same sequence as SEQ ID NO: 201-205 of Table 6e The amino acid sequence of any of them has at least 95%, 96%, 97%, 98%, 99% sequence identity or an amino acid sequence identical to the amino acid sequence.

In some embodiments, the invention provides antigen-binding fragments (e.g., AF1 or AF2) that bind to the CD3 protein complex with enhanced activity compared to CD3-binding antibodies or antigen-binding fragments known in the art. stability. In addition, the CD3 antigen-binding fragments of the present invention are designed to confer a higher degree of stability on the chimeric bispecific antigen-binding fragment compositions into which they have been integrated, thereby eliciting a fusion protein when administered to an individual. Improved performance and recovery, extended shelf life and increased stability. In one approach, the CD3 AFs of the invention are designed to have a higher degree of thermal stability than certain CD3-binding antibodies and antigen-binding fragments known in the art. Therefore, CD3 AF used as a component of a chimeric bispecific antigen-binding fragment composition into which CD3 AF has been incorporated exhibits advantageous pharmaceutical properties, including high thermal stability and low tendency to aggregate, thereby improving the stability of the CD3 AF during manufacture and storage. Causes improved performance and recovery and promotes long serum half-life. Biophysical properties such as thermal stability are often constrained by antibody variable domains, which vary widely in their intrinsic properties. High thermal stability is often associated with high expression and other desirable properties, including less susceptibility to aggregation (Buchanan A et al. Engineering a therapeutic IgG molecule to address cystineylation, aggregation and enhance thermal stability and expression. MAbs 2013;5:255). Thermal stability is determined by measuring the "melting temperature" ( _Tm ), which is defined as the temperature at which half of the molecules are denatured. The melting temperature of each dimer is indicative of its thermal stability. In vitro assays for determining _Tm are known in the art and include the methods described in the Examples below. The melting point of the heterodimer can be measured using techniques such as differential scanning calorimetry (Chen et al. (2003) Pharm Res 20:1952-60; Ghirlando et al. (1999) Immunol Lett 68:47-52). Alternatively, the thermal stability of the heterodimer can be measured using circular dichroism (Murray et al. (2002) J. Chromatogr Sci 40:343-9) or as described in the Examples below.

In some embodiments of the polypeptides of the present invention, the antigen-binding fragment (e.g., AF1 or AF2) may exhibit higher thermal stability than an anti-CD3-binding fragment consisting of the sequence of SEQ ID NO: 206 (see Table 6e ), as shown in Evidenced in an in vitro assay by: a higher melting temperature (Tm) of the first antigen-binding fragment relative to the melting temperature ( _Tm ) of the anti-CD3 binding fragment; or upon incorporation of the first antigen-binding fragment into the assay After incubation in the bispecific antigen-binding construct, the higher _Tm of the test bispecific antigen-binding construct relative to the Tm of the control bispecific antigen-binding construct, wherein the test bispecific antigen-binding construct comprises the first An antigen-binding fragment and a reference antigen-binding fragment that binds to an antigen other than CD3; and wherein the control bispecific antigen-binding construct consists of an anti-CD3-binding fragment and a reference antigen-binding fragment, the anti-CD3-binding fragment consisting of SEQ ID NO:206 Sequence (see Table 6e ) composition. The melting temperature ( _Tm ) of the first antigen-binding fragment may be at least 2°C higher, or at least 3°C higher, or at least 4°C higher than the _Tm of the anti-CD3-binding fragment consisting of the sequence of SEQ ID NO: 206 (see Table 6e ). °C, or at least 5 °C higher.

The thermal denaturation curves of the CD3 binding fragment of the present invention and the anti-CD3 bispecific antibody comprising the anti-CD3 binding fragment and the reference binding fragment show that the construct of the present invention is compared to the sequence shown in SEQ ID NO: 781 (see Table 6f ) or a reference bispecific antibody and a reference antigen-binding fragment that binds to the HER2 embodiments described herein are more resistant to heat denaturation, wherein the control bispecific antigen-binding fragment comprises SEQ ID NO: 781 (see Table 6f ). In one embodiment, the polypeptide of any one of the inventive composition embodiments described herein comprises the anti-CD3 AF of the embodiments described herein, wherein the _Tm ratio of AF is determined by the sequence of SEQ ID NO: 781 ( See Table 6f ) comprising an antigen-binding fragment having a _Tm that is at least 2°C higher, or at least 3°C higher, or at least 4°C higher, or at least 5°C higher, or at least 6°C higher, or at least 7°C higher, or at least at least 7°C higher. 8°C, or at least 9°C higher, or at least 10°C higher, as determined by melting temperature increase in an in vitro assay.

In some embodiments, the polypeptide of any one of the inventive composition embodiments described herein comprises an antigen-binding fragment (AF) that specifically binds human or cynomolgus monkey (cyno) CD3. Antigen-binding fragments ( AF ) can specifically bind human CD3. Antigen-binding fragments ( AF ) can bind to subunits of the CD3 complex of CD3 identified herein as CD3ε, CD3δ, CD3γ, or CD3ζ units. Antigen-binding fragments ( AF ) can bind to the CD3ε fragment of CD3. The antigen-binding fragment ( AF ) may have a dissociation constant ( _Kd ) constant specificity of between about 10 nM and about 400 nM, or between about 50 nM and about 350 nM, or between about 100 nM and 300 nM Binding to human or cyno CD3 as determined in an in vitro antigen binding assay involving human or cyno CD3 antigen. In some embodiments, the polypeptide of any one of the inventive composition embodiments described herein comprises an antigen-binding fragment (AF) at less than about 10 nM, or about 50 nM, or about 100 nM, or about 150 nM, or about 200 nM, or about 250 nM, or about 300 nM, or about 350 nM, or a dissociation constant ( _Kd ) weaker than about 400 nM specifically binds human or cyno CD3, as in vitro As determined in the antigen binding assay. For clarity, the antigen-binding fragment (AF) with a _Kd of 400 binds its ligand weaker than the antigen-binding fragment (AF) with a _Kd of 10 nM. In some embodiments, the polypeptide of any one of the inventive composition embodiments described herein comprises an antigen-binding fragment (AF) represented by the amino acid sequence of SEQ ID NO: 781 (see Table 6f ) comprising an antigen-binding fragment that is at least 2-fold, 3-fold, 4-fold, 5-fold, 6-fold, 7-fold, 8-fold, 9-fold, or at least 10-fold weaker in binding affinity to specifically bind human or cyno CD3, such as in vitro Antigen binding assays were determined by respective dissociation constants (K _d ). In some embodiments, the invention provides bispecific polypeptides comprising an antigen-binding fragment (AF) that exhibits a binding affinity for CD3 (anti-CD3 AF) relative to that described herein incorporated into a polypeptide of the invention. The binding affinity of the anti-HER2 AF embodiments is at least 2-fold, 3-fold, 4-fold, 5-fold, 6-fold, 7-fold, 8-fold, 9-fold, 10-fold, 20-fold, 50-fold, 100-fold or at least 1000-fold, as determined by the respective dissociation constants (K _d ) in an in vitro antigen binding assay. The binding affinity of the compositions of the invention for the ligand of interest can be analyzed using binding or competitive binding assays such as Biacore assays for chip-bound receptors or binding proteins or ELISA as described in U.S. Patent No. 5,534,617 Assays, assays described in the Examples herein, radioreceptor assays, or other assays known in the art. Binding affinity constants can then be determined using standard methods such as Scatchard analysis as described by van Zoelen et al., Trends Pharmacol Sciences (1998) 19) 12):487 or this technique other known methods.

In a related aspect, the invention provides antigen-binding fragments (AF) that bind to CD3 (anti-CD3 AF) and are incorporated into chimeric bispecific polypeptide compositions designed to have isoelectric The point (pi), which confers enhanced stability to the compositions of the invention compared to corresponding compositions comprising CD3-binding antibodies or antigen-binding fragments known in the art. In one embodiment, the polypeptide of any one of the inventive composition embodiments described herein comprises an AF that binds to CD3 (anti-CD3 AF), wherein the anti-CD3 AF exhibits a value between 6.0 and 6.6, inclusive ) pI. In some embodiments, the polypeptide of any one of the inventive composition embodiments described herein comprises an AF that binds to CD3 (anti-CD3 AF), wherein the anti-CD3 AF exhibits a pi that is greater than that of a reference antigen-binding fragment ( e.g., Consisting of the sequence shown in SEQ ID NO: 206 (see Table 6e )) has a pi lower by at least 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9 or 1.0 pH units. In some embodiments, the polypeptide of any one of the inventive composition embodiments described herein comprises an AF that binds to CD3 (anti-CD3 AF) in combination with another AF that binds to a HER2 antigen (anti-HER2 AF ) fusion wherein the anti-CD3 AF exhibits a pi that is at least 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 1.1, 1.2 of the pi of the AF that binds the HER2 antigen or an epitope thereof , 1.3, 1.4 or 1.5 pH units. In some embodiments, the polypeptide of any one of the inventive composition embodiments described herein comprises an AF that binds to CD3 (anti-CD3 AF) fused to an AF that binds to a HER2 antigen (anti-HER2 AF) wherein the anti-HER2 AF exhibits a pi that is at least about 0.1 to about 1.5, or at least about 0.3 to about 1.2, or at least about 0.5 to about 1.0, or at least about 0.7 to about 0.9 pH units of the pi of the anti-CD3 AF Inside. It is particularly contemplated that by such design in which the pi of the two antigen-binding fragments are within these ranges, the resulting fused antigen-binding fragment will confer a chimeric bispecific antigen-binding fragment composition into which the fused antigen-binding fragments have been integrated. A higher degree of stability resulting in improved expression and enhanced recovery of the fusion protein in soluble, non-aggregated form when the composition is administered to an individual, increased shelf-life of the formulated chimeric bispecific polypeptide composition, and stability enhanced. Having two AFs of different states (anti-CD3 AF and anti-HER2 AF) within a relatively narrow pi range allows selection of a buffer or other solution in which both AFs (anti-CD3 AF and anti-HER2 AF) are stable, by This promotes the overall stability of the composition. Antigen-binding fragments ( AF ) may exhibit an isoelectric point (pi) of less than or equal to 6.6. Antigen-binding fragments ( AF ) may exhibit an isoelectric point (pi) between 6.0 and 6.6, inclusive. The antigen- binding fragment ( AF ) exhibits an isoelectric point ( pI ) that is at least 0.1, 0.2, 0.3, 0.4, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9 or 1.0 pH units. The antigen-binding fragment ( AF ) can be specific at a dissociation constant ( _Kd ) constant (such as determined in an in vitro antigen binding assay involving human or cyno CD3 antigen) between about 10 nM and about 400 nM Combined with human or cyno CD3. The antigen-binding fragment ( AF ) may be less than about 10 nM, or less than about 50 nM, or less than about 100 nM, or less than about 150 nM, or less than about 200 nM, or less than about 250 nM, or less than about 300 nM, or less than A dissociation constant ( _Kd ) of about 350 nM, or less than about 400 nM, such as determined in an in vitro antigen binding assay, specifically binds human or cyno CD3. The antigen-binding fragment ( AF ) may exhibit a binding affinity for CD3 that is at least 2-fold, 3-fold weaker than the binding affinity of the antigen-binding fragment consisting of the amino acid sequence of SEQ ID NO: 206 (see Table 6e ) fold, 4 fold, 5 fold, 6 fold, 7 fold, 8 fold, 9 fold or at least 10 fold (such as determined by the respective dissociation constant ( _Kd ) in an in vitro antigen binding assay).

In certain embodiments, the VL and VH of the antigen-binding fragment are fused by a relatively long linker consisting of 25, 26, 27, 28, 29, 30, 31, 32, 33, 34 or 35 Composed of two hydrophilic amino acids, the linkers have the characteristics of flexibility when joined together. In one embodiment, the VL and VH of any of the scFv embodiments described herein are linked by a relatively long linker with hydrophilic amino acids having the sequence GSGEGSEGEGGGEGSEGEGSGEGGEGEGSG( SEQ ID NO: 82), TGSGEGSEGEGGGEGSEGEGSGEGGEGEGSGT (SEQ ID NO: 83), GATPPETGAETESPGETTGGSAESEPPGEG (SEQ ID NO: 84) or GSAAPTAGTTPSSPAPPTGGSSAAGSPST (SEQ ID NO: 85). In some embodiments, AF1 and AF2 are linked together by a short linker with hydrophilic amino acids of 3, 4, 5, 6 or 7 amino acids. In one embodiment, the short linker sequence is identified herein as the sequence SGGGGS (SEQ ID NO: 86), GGGGS (SEQ ID NO: 87), GGSGGS (SEQ ID NO: 88), GGS or GSP. In some embodiments, the invention provides compositions comprising single chain diabodies, wherein after folding, the first domain (VL or VH) is paired with the last domain (VH or VL) to form one scFv and the middle two The domains are paired to form another scFv, wherein the first and second domains and the third and last domain are fused together by one of the aforementioned short linkers, and the second and third variable domains are The domains are fused by one of the aforementioned relatively long linkers. As will be appreciated by those skilled in the art, selection of short linkers and relatively long linkers prevents improper pairing of adjacent variable domains, thereby facilitating formation of VL and VH comprising a first antigen-binding fragment and a second antigen-binding fragment Single-chain bifunctional antibody configuration. Table 6b. Exemplary CD3 CDR sequences Construct CDR region amino acid sequence SEQ ID NO: 3.23, 3.30, 3.31, 3.32 CDR-L1 RSS N GAVT S SNYAN 1 3.24 CDR-L1 RSS N G E VTTSNYAN 2 3.33, 3.9 CDR-L1 RSSTGAVTTSNYAN 3 3.23, 3.30, 3.31, 3.32, 3.9, 3.33 CDR-L2 GTNKRAP 4 3.24 CDR-L2 GT I KRAP 5 3.23, 3.24, 3.30, 3.31, 3.32 CDR-L3 ALWY P NLWVF 6 3.33, 3.9 CDR-L3 ALWYSNLWVF 7 3.23, 3.24, 3.30, 3.31, 3.32, 3.9, 3.33 CDR-H1 GFTFNTYAMN 8 3.23, 3.24, 3.30, 3.31, 3.32, 3.9, 3.33 CDR-H2 RIRSKYNNYATYYADSVKD 9 3.23. 3.24, 3.30, 3.31, 3.32 CDR-H3 H E NFGNSYVSWFA H 10 3.9, 3.33 CDR-H3 HGNFGNSYVSWFAY 11 Table 6c. Exemplary CD3 FR sequences Construct FR area amino acid sequence SEQ ID NO: 3.23, 3.24, 3.30, 3.31, 3.32, 3.9, 3.33 FR-L1 ELVVTQEPSLTVSPGGTVTLTC 51 3.23, 3.24, 3.30, 3.31, 3.32, 3.9, 3.33 FR-L2 WVQQKPGQAPRGLIG 52 3.23, 3.24 FR-L3 GTPARFSGSLLGGKAALTLSGVQPEDEA V YYC 53 3.30 FR-L3 GTPARFSGS S LGGKAALTLSGVQPEDEA V YYC 54 3.31 FR-L3 GTPARFSGSLLGG S AALTLSGVQPEDEA V YYC 55 3.32 FR-L3 GTPARFSGS S LGG S AALTLSGVQPEDEA V YYC 56 3.9 FR-L3 GTPARFSGSLLGGKAALTLSGVQPEDEAEYYC 57 3.33 FR-L3 GTPARFSGS S LGG S AALTLSGVQPEDEAEYYC 58 3.23, 3.24, 3.30, 3.31, 3.32, 3.9, 3.33 FR-L4 GGGTKLTVL 59 3.23, 3.24 FR-H1 EVQLLESGGG I VQPGGSLKLSCAAS 60 3.30, 3.31, 3.32 FR-H1 EVQL Q ESGGG I VQPGGSLKLSCAAS 61 3.33 FR-H1 EVQL Q ESGGGLVQPGGSLKLSCAAS 62 3.9 FR-H1 EVQLLESGGGLVQPGGSLKLSCAAS 63 3.23, 3.24, 3.30, 3.31, 3.32, 3.9, 3.33 FR-H2 WVRQAPGKGLEWVA 64 3.23, 3.24, 3.30, 3.31, 3.32 FR-H3 RFTISRDDSKNT V YLQMNNLKTEDTAVYYCVR 65 3.9, 3.33 FR-H3 RFTISRDDSKNTAYLQMNNLKTEDTAVYYCVR 66 3.23, 3.24, 3.30, 3.31, 3.32, 3.9, 3.33 FR-H4 WGQGTLVTVSS 67 Table 6d: Exemplary CD3 VL and VH sequences Construct Area amino acid sequence SEQ ID NO: 3.23 VL ELVVTQEPSLTVSPGGTVTLTCRSS N GAVT S SNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSLLGGKAALTLSGVQPEDEA V YYCALWY P NLWVFGGGTKLTVL 101 3.23, 3.24 VH EVQLLESGGG I VQPGGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNT V YLQMNNLKTEDTAVYYCVRH E NFGNSYVSWFA H WGQGTLVTVSS 102 3.24 VL ELVVTQEPSLTVSPGGTVTLTCRSS N G E VTTSNYANWVQQKPGQAPRGLIGGT I KRAPGTPARFSGSLLGGKAALTLSGVQPEDEA V YYCALWY P NLWVFGGGTKLTVL 103 3.30 VL ELVVTQEPSLTVSPGGTVTLTCRSS N GAVT S SNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGS S LGGKAALTLSGVQPEDEA V YYCALWY P NLWVFGGGTKLTVL 104 3.30, 3.31, 3.32 VH EVQL Q ESGGG I VQPGGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNT V YLQMNNLKTEDTAVYYCVRH E NFGNSYVSWFA H WGQGTLVTVSS 105 3.31 VL ELVVTQEPSLTVSPGGTVTLTCRSS N GAVT S SNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSLLGG S AALTLSGVQPEDEA V YYCALWY P NLWVFGGGTKLTVL 106 3.32 VL ELVVTQEPSLTVSPGGTVTLTCRSS N GAVT S SNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGS S LGG S AALTLSGVQPEDEA V YYCALWY P NLWVFGGGTKLTVL 107 3.9 VL ELVVTQEPSLTVSPGGTVTLTCRSSTGAVTTSNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCALWYSNLWVVFGGGTKLTVL 108 3.9 VH EVQLLESGGGLVQPGGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYVSWFAYWGQGTLVTVSS 109 3.33 VL ELVVTQEPSLTVSPGGTVTLTCRSSTGAVTTSNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSSLGGSAALTLSGVQPEDEAEYYCALWYSNLWVFGGGTKLTVL 110 3.33 VH EVQLQESGGGLVQPGGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYVSWFAYWGQGTLVTVSS 111 Table 6e: Exemplary CD3 scFv sequences Construct amino acid sequence SEQ ID NO: 3.23 ELVVTQEPSLTVSPGGTVTLTCRSS N GAVT S SNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSLLGGKAALTLSGVQPEDEA V YYCALWY P NLWVFGGGTKLTVLGATPPETGAETESPGETTGGSAESEPPGEGEVQLLESGGG I VQPGGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNT V YLQMNNLKTEDTAVYYCVRH E NFGNSYVSWFA H WGQGTLVTVSS 201 3.24 ELVVTQEPSLTVSPGGTVTLTCRSS N G E VTTSNYANWVQQKPGQAPRGLIGGT I KRAPGTPARFSGSLLGGKAALTLSGVQPEDEA V YYCALWY P NLWVFGGGTKLTVLGATPPETGAETESPGETTGGSAESEPPGEGEVQLLESGGG I VQPGGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNT V YLQMNNLKTEDTAVYYCVRH E NFGNSYVSWFA H WGQGTLVTVSS 202 3.30 ELVVTQEPSLTVSPGGTVTLTCRSS N GAVT S SNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGS S LGGKAALTLSGVQPEDEA V YYCALWY P NLWVFGGGTKLTVLGATPPETGAETESPGETTGGSAESEPPGEGEVQL Q ESGGG I VQPGGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNT V YLQMNNLKTEDTAVYYCVRH E NFGNSYVSWFA H WGQGTLVTVSS 203 3.31 ELVVTQEPSLTVSPGGTVTLTCRSS N GAVT S SNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSLLGG S AALTLSGVQPEDEA V YYCALWY P NLWVFGGGTKLTVLGATPPETGAETESPGETTGGSAESEPPGEGEVQL Q ESGGG I VQPGGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNT V YLQMNNLKTEDTAVYYCVRH E NFGNSYVSWFA H WGQGTLVTVSS 204 3.32 ELVVTQEPSLTVSPGGTVTLTCRSS N GAVT S SNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGS S LGG S AALTLSGVQPEDEA V YYCALWY P NLWVFGGGTKLTVLGATPPETGAETESPGETTGGSAESEPPGEGEVQL Q ESGGG I VQPGGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNT V YLQMNNLKTEDTAVYYCVRH E NFGNSYVSWFA H WGQGTLVTVSS 205 3.9 ELVVTQEPSLTVSPGGTVTLTCRSSTGAVTTSNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCALWYSNLWVFGGGTKLTVLGATPPETGAETESPGETTGGSAESEPPGEGEVQLLESGGGLVQPGGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYVSWFAYWGQGTLVTVSS 206 3.33 ELVVTQEPSLTVSPGGTVTLTCRSSTGAVTTSNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSSLGGSAALTLSGVQPEDEAEYYCALWYSNLWVFGGGTKLTVLGATPPETGAETESPGETTGGSAESEPPGEGEVQLQESGGGLVQPGGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYVSWFAYWGQGTLVTVSS 207 4.11 QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNYVYWYQQLPGTAPKLLIYRNNQRPSGVPDRFSGSKSGTSASLAISGLRSEDEADYYCAAWDDSLSGLWVFGGGTKLTVLGATPPETGAETESPGETTGGSAESEPPGEGQVQLQQWGGGLVKPGGSLRLSCAASGFTFSSYSMNWVRQAPGKGLEWVSRINSDGSSTNYADSVKGRFTISRDNAKNTLYLQMNSLRAEDTAVYYCARELRWGNWGQGTLVTVSS 208 4.12 QAGLTQPPSASGTPGQRVTLSCSGSYSNIGTYYVYWYQQLPGTAPKLLIYSNDQRLSGVPDRFSGSKSGTSASLAISGLQSEDEAAYYCAAWDDSLNGWAFGGGTKLTVLGATPPETGAETESPGETTGGSAESEPPGEGQVQLQQWGGGLVKPGGSLRLSCAASGFTFSSYSMNWVRQAPGKGLEWVSRINSDGSSTNYADSVKGRFTISRDNAKNTLYLQMNSLRAEDTAVYYCARELRWGNWGQGTLVTVSS 209 4.13 QPGLTQPPSASGTPGQRVTLSCSGRSSNIGSYYVYWYQHLPGMAPKLLIYRNSRRPSGVPDRFSGSKSGTSASLVISGLQSDDEADYYCAAWDDSLKSWVFGGGTKLTVLGATPPETGAETESPGETTGGSAESEPPGEGQVQLQQWGGGLVKPGGSLRLSCAASGFTFSSYSMNWVRQAPGKGLEWVSRINSDGSSTNYADSVKGRFTISRDNAKNTLYLQMNSLRAEDTAVYYCARELRWGNWGQGTLVTVSS 210 4.14 QSVLTQPPSASGTPGQRVTISCSGSSSNIGTNYVYWYQQFPGTAPKLLIYSNNQRPSGVPDRFSGSKSGTSGSLAISGLQSEDEADYSCAAWDDSLNGWVFGGGTKLTVLGATPPETGAETESPGETTGGSAESEPPGEGQVQLVQWGGGLVKPGGSLRLSCAASGFTFSSYSMNWVRQAPGKGLEWVSRINSDGSSTNYADSVKGRFTISRDNAKNTLYLQMNSLRAEDTAVYYCARELRWGNWGQGTLVTVSS 211 4.15 QPGLTQPPSASGTPGQRVTISCSGSSSNIGSNYVYWYQQLPGTAPKLLIYRNNQRPSGVPDRLSGSKSGTSASLAISGLRSEDEADYYCAAWDDSLSGWVFGGGTKLTVLGATPPETGAETESPGETTGGSAESEPPGEGQVQLVQWGGGLVKPGGSLRLSCAASGFTFSSYSMNWVRQAPGKGLEWVSRINSDGSSTNYADSVKGRFTISRDNAKNTLYLQMNSLRAEDTAVYYCARELRWGNWGQGTLVTVSS 212 4.16 QAVLTQPPSASGTPGQRVTISCSGSSSNIGSYYVYWYQQVPGAAPKLLMRLNNQRPSGVPDRFSGAKSGTSASLVISGLRSEDEADYYCAAWDDSLSGQWVFGGGTKLTVLGATPPETGAETESPGETTGGSAESEPPGEGQVQLQQWGGGLVKPGGSLRLSCAASGFTFSSYSMNWVRQAPGKGLEWVSRINSDGSSTNYADSVKGRFTISRDNAKNTLYLQMNSLRAEDTAVYYCARELRWGNWGQGTLVTVSS 213 4.17 QAGLTQPPSASGTPGQRVTISCSGSSSNIGSNYVYWYQQLPGTAPKLLIYRNNQRPSGVPDRFSGSKSGTSASLAISGLRSEDEADYYCATWDASLSGWVFGGGTKLTVLGATPPETGAETESPGETTGGSAESEPPGEGEVQLVQWGGGLVKPGGSLRLSCAASGFTFSSYSMNWVRQAPGKGLEWVSRINSDGSSTNYADSVKGRFTISRDNAKNTLYLQMNSLRAEDTAVYYCARELRWGNWGQGTLVTVSS 214 Anti-HER-2 binding domain

In some embodiments, the invention provides chimeric polypeptide aggregate compositions comprising a first partial binding domain having binding affinity for the tumor-specific marker HER-2 and a second binding domain that binds to an effector cell antigen, such as the CD3 antigen . In one embodiment, the binding domain comprises VL and VH derived from a monoclonal antibody directed against HER-2. Monoclonal antibodies against HER-2 are known in the art. Illustrative, non-limiting examples of VL and VH sequences are presented in Table 6f . In one embodiment, the invention provides a chimeric polypeptide assembly composition comprising a first partial binding domain having binding affinity for the tumor-specific marker HER-2, the first partial binding domain comprising an anti-HER2 as set forth in Table 6f VL and VH sequences. In some embodiments, the present invention provides a chimeric polypeptide assembly composition comprising a first part of the binding domain having binding affinity for a tumor-specific marker, the first part of the binding domain comprising a CDR-L1 region, a CDR-L2 region, a CDR -L3 region, CDR-H1 region, CDR-H2 region and CDR-H3 region, wherein each region is derived from the respective VL and VH sequences set forth in Table 6f . Preferably, in embodiments, the binding has a K _d value of greater than 10 ⁻¹⁰ to 10 ⁻⁷ M, as determined in an in vitro binding assay. In some embodiments, where the polypeptide comprises an antigen-binding fragment (anti-HER2 AF) that specifically binds to HER2, the anti-HER2 AF (eg, AF1 or AF2) may comprise: (1) comprising SEQ ID set forth as Table 6f The heavy chain variable region ( VHII) of the amino acid sequence of NO: 778-783 and (2) the light chain variable region (VH _II ) comprising the amino acid sequence of SEQ ID NO: 878-883 set forth as Table 6f _II ). It is specifically contemplated that the chimeric polypeptide assembly composition may comprise any of the foregoing binding domains or sequence variants thereof, so long as such variants exhibit binding specificity for the described antigen. In one embodiment, sequence variants will be produced by substituting different amino acids for amino acids in the VL or VH sequence. In deletion variants, one or more amino acid residues in a VL or VH sequence as described herein are removed. Thus, deletion variants include all fragments of the binding domain polypeptide sequence. In substitution variants, one or more amino acid residues of a VL or VH (or CDR) polypeptide are removed and replaced with alternative residues. In one aspect, the substitutions are conservative in nature, and conservative substitutions of this type are well known in the art. Additionally, it is specifically contemplated that compositions comprising the first and second binding domains disclosed herein may be used in any of the methods disclosed herein. Table 6f. Anti-HER2 monoclonal antibodies and sequences brand name Antibody name Target VH sequence SEQ ID NO: VL sequence SEQ ID NO: C1 HER2 QVQLVESGGGLVQPGGSLRLSCAASGFTFS SYAMG WVRQAPGKGLEWVS SISGSSRYIYYADSVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCAK MDASGSYFNF WGQGTLVTVSS 778 QSPSSFLSAFVGDRITITC RASPGIRNYLA WYQQKPGKAPKLLIY AASTLQS GVPSRFSGSGSGTDFTLTISSLQPEDFATYYC QQYNSYPLS FGGGTKVEIK 878 Erbicin HER2 QVQLLQSAAEVKKPGESLKISCKGSGYSFT SYWIG WVRQMPGKGLEWMG IIYPGDSDTRYSPSFQG QVTISADKSISTAYLQWSSLKASDTAVYYCAR WRDSPL WGQGTLVTVSS 779 QAVVTQEPSFSVSPGGTVTLTC GLSSGSVSTSYYPS WYQQTPGQAPRTLIY STNTRSS GVPDRFSGSILGNKAALTITGAQADDESDYYC VLYMGSGQYV FGGGTKLTVL 879 Herceptin Trastuzumab HER2 EVQLVESGGGLVQPGGSLRLSCAAS GFNIKDTY IHWVRQAPGKGLEWVAR IYPTNGYT RYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYC SRWGGDGFYAMDY WGQGTLVTVSS 780 DIQMTQSPSSLSASVGDRVTITCRAS QDVNTA VAWYQQKPGKAPKLLIY SAS FLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYC QQHYTTPPT FGQGTKVEIK 880 MAGH22 Margotuximab HER2 QVQLQQSGPELVKPGASLKLSCTAS GFNIKDTY IHWVKQRPEQGLEWIGR IYPTNGYT RYDPKFQDKATITADTSSNTAYLQVSRLTSEDTAVYYC SRWGGDGFYAMDY WGQGASVTVSS 781 DIVMTQSHKFMSTSVGDRVSITCKAS QDVNTA VAWYQQKPGHSPKLLIY SAS FRYTGVPDRFTGSRSGTDFFTISSVQAEDLAVYYC QQHYTTPPT FGGGTKVEIK 881 MM-302 F5 HER2 QVQLVESGGGLVQPGGSLRLSCAASGFTFR SYAMS WVRQAPGKGLEWVS AISGRGDNTYYADSVKG RFTISRDNSKNTLYLQMNSLRAEDTAVYYC AKMTSNAFAFDY WGQGTLVTVSS 782 QSVLTQPPSVSGAPGQRVTISC TGSSSNIGAGYGVH WYQQLPGTAPKLLIY GNTNRPS GVPDRFSGFKSGTSASLAITGLQAEDEADYYC QFYDSSSLSGWV FGGGTKLTVL 882 Perjeta Pertuzumab HER2 EVQLVESGGGLVQPGGSLRLSCAAS GFTFTDYT MDWVRQAPGKGLEWVAD VNPNSGGS IYNQRFKGRFTLSVDRSKNTLYLQMNSLRAEDTAVYYC ARNLGPSFYFDY WGQGTLVTVSS 783 DIQMTQSPSSLSASVGDRVTITCKASQ DVSIG VAWYQQKPGKAPKLLIY SAS YRYTGVPSRFSGSGSGTDFTLTISSLQPEDFATYYC QQYYIYPYT FGQGTKVEIK 883 *If underlined and bolded sequences are present, they are CDRs within VL and VH Table A: Intramolecular long linkers Connector number name SEQ ID amino acid sequence L1 (G4S)3 112 GGGGSGGGGSGGGGS L2 MT110_18 113 GEGTSTGSGGSGGSGGAD L3 MT103_18 114 VEGGSGGSGGSGGSGGVD L4 UCHT1_29 115 RTSGPGDGGKGGPGKGPGGEGTKGTGPGG L5 Y30 116 GSGEGSEGEGGGEGSEGEGSGEGGEGEGSG L6 Y32 117 TGSGEGSEGEGGGEGSEGEGSGEGGEGEGSGT L7 G1_30_3 118 GATPPETGAETESPGETTGGSAESEPPGEG L8 G9_30_1 119 GSAAPTAGTTPSASPAPPPTGGSSAAGSPST L9 Y30_modified 120 GEGGESGGSEGEGSGEGEGGSGGEGESEGG L10 G1_30_1 121 STETSPSTPTTESPEAGSGSGSPSPSGTEA L11 G1_30_2 122 PTGTTGEPSGEGSEPEGSAPTSSTSEATPS L12 G1_30_4 123 SESESEGEAPTGPGASTTPEPSESPTPETS L13 UCHT1_modified 124 PEGGESGEGTGPGTGGEPEGEGGPGGEGGT Table B: Intermolecular Short Linkers name amino acid sequence S-1 SGGGGS (SEQ ID NO: 86) S-2 GGGGS (SE ID NO: 87) S-3 GGS S-4 GSP

In some embodiments of the polypeptides of the present invention, one of the antigen-binding fragments may have a light chain variable region (VL) and a heavy chain variable region (VH) via a linker or a long linker (eg, having a hydrophilic amine group). acid) connection. The linker linking the light chain variable region (VL) and the heavy chain variable region (VH) of the antigen-binding fragment (e.g., the first antigen-binding fragment (AF1), the second antigen-binding fragment (AF2)) can be (each independently ) comprising an amine having at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to the sequence set forth in Table A amino acid sequence. The linker linking the light chain variable region (VL) and the heavy chain variable region (VH) of the antigen-binding fragment (e.g., the first antigen-binding fragment (AF1), the second antigen-binding fragment (AF2)) can be (each independently ) comprising an amino acid sequence consistent with the sequences set forth in Table A. In some embodiments of the polypeptides of the invention, two antigen-binding fragments (eg, a first antigen-binding fragment and a second antigen-binding fragment) can be fused together via a peptide linker or a short linker. The peptide linker linking two antigen-binding fragments (e.g., a first antigen-binding fragment and a second antigen-binding fragment) may comprise at least 90%, 91%, 92%, 93%, 94% of the sequence set forth in Table B Amino acid sequences with %, 95%, 96%, 97%, 98%, 99% or 100% sequence identity. The peptide linker linking two antigen-binding fragments (e.g., a first antigen-binding fragment and a second antigen-binding fragment) may comprise an amino acid sequence consistent with the sequences set forth in Table B. In some instances, the first antigen-binding fragment is a single chain variable fragment (scFv). In some instances, the second antigen-binding fragment is a single chain variable fragment (scFv). The two single chain variable fragments of the first antigen-binding fragment and the second antigen-binding fragment can be linked together by a peptide linker. In some embodiments of the polypeptide of the present invention, the linker used to connect the VL and VH of the first antigen-binding fragment or/and the linker used to connect the VL and VH of the second antigen-binding fragment can be L7 of Table A . In these embodiments, the peptide linker used to connect the two antigen-binding fragments can be S-1 or S-2 of Table B. In some embodiments, the invention provides polypeptides comprising single chain diabodies, wherein after folding, the first domain (VL or VH) is paired with the last domain (VH or VL) to form a scFv and the two middle domains Pairing to form another scFv, wherein the first domain and the second domain and the third domain and the last domain are fused together by a short linker with hydrophilic amino acids, which are herein Identified by the sequences set forth in Table B , and the second and third variable domains are fused by the long linker identified in Table A. As will be appreciated by those skilled in the art, selection of short and long linkers prevents improper pairing of adjacent variable domains, thereby facilitating the formation of single-chain doublets comprising the VL and VH of the first and second binding moieties. Functional antibody configuration. Table C: Exemplary spacers between the release segment and the bispecific antibody constructs amino acid sequence SEQ ID NO: STEPS 89 SATPESGPGT 90 ATSGSETPGT 91 GTAEAASASG 92 STEPSEGSAPGTS 93 SGPGTS 94 GT STEPS 95

In some embodiments of the polypeptide of the present invention, the release segment (RS) (such as the first release segment (RS1), the second release segment (RS2), etc.) can be combined with the bispecific antibody construct through a spacer (BsAb) fusion. The spacers may (independently) comprise at least four types of amino acids, which are glycine (G), alanine (A), serine (S), threonine (T ), glutamic acid (E) or proline (P). A peptide of the invention may comprise a first release segment fused to the bispecific antibody construct via a first spacer and a second release segment fused to the bispecific antibody construct via a second spacer. A spacer ( e.g. , a first spacer, a second spacer, etc.) can comprise (each independently) at least (about) 80%, at least (about) 90%, or 100% sequence identity to the sequences set forth in Table C the amino acid sequence. A spacer ( e.g. , a first spacer, a second spacer, etc.) can (each independently) comprise an amino acid sequence identical to the sequence set forth in Table C. unstructured configuration

Typically, the XTEN component of the fusion protein is designed to behave like a denatured peptide sequence under physiological conditions, even though the length of the polymer is extended. Denaturation describes the state of a peptide in solution characterized by a larger conformational freedom of the peptide backbone. Most peptides and proteins adopt a denatured configuration in the presence of high concentrations of denaturants or at elevated temperatures. Peptides in the denatured configuration have, for example, characteristic circular dichroism (CD) spectra and are characterized by no long-range interactions as determined by NMR. "Denatured conformation" and "unstructured conformation" are used synonymously herein. In some cases, the invention provides XTEN sequences that can resemble denatured sequences that are largely free of secondary structure under physiological conditions. In other cases, the XTEN sequence may be substantially free of secondary structure under physiological conditions. "Substantially free" as used in this context means that less than 50% of the XTEN amino acid residues of the XTEN sequence contribute to secondary structure, as measured or determined by the means described herein. "Essentially free" as used in this context means at least about 60%, or about 70%, or about 80%, or about 90%, or about 95%, or about 90% or about 95% of the XTEN amino acid residues of the XTEN sequence, or At least about 99% does not contribute to secondary structure, as measured or determined by the means described herein.

Various methods have been established in the art to discern the presence or absence of secondary and tertiary structure in a given polypeptide. In particular, the XTEN secondary structure can be measured spectrophotometrically, for example by circular dichroism spectroscopy in the "far UV" spectral region (190-250 nm). Secondary structure elements such as α-helices and β-sheets each give rise to the characteristic shape and magnitude of the CD spectrum. Secondary structure can also be predicted for polypeptide sequences by certain computer programs or algorithms, such as the well-known Chou-Fasman algorithm (Chou, PY et al. (1974) Biochemistry , 13: 222-45) and Garnier-Osguthorpe-Robson ("GOR") algorithm (Garnier J, Gibrat JF, Robson B. (1996), GOR method for predicting protein secondary structure from amino acid sequence. Methods Enzymol 266:540-553), such as US Patent Described in Application Publication No. 20030228309A1. For a given sequence, the algorithm can predict the presence of some secondary structure or no secondary structure at all, expressed as the total number and/or percentage of residues forming the sequence such as an α-helix or β-sheet or predicted to cause random Percentage of residues of coil-forming sequences that have no secondary structure.

In some cases, the XTEN sequences used in the fusion protein compositions of the invention can have an alpha-helix percentage ranging from 0% to less than about 5%, as determined by the Chou-Fasman algorithm. In other cases, the XTEN sequence of the fusion protein composition can have a percent beta-sheet ranging from 0% to less than about 5%, as determined by the Chou-Fasman algorithm. In some cases, the XTEN sequence of the fusion protein composition can have a percentage of α-helices ranging from 0% to less than about 5% and a percentage of β-sheets ranging from 0% to less than about 5%, as described by Chou - Determined by the Fasman algorithm. In preferred embodiments, the XTEN sequence of the fusion protein composition will have an alpha-helix percentage of less than about 2% and a beta-sheet percentage of less than about 2%. In other cases, the XTEN sequence of the fusion protein composition may have a high degree of random coil percentage, as determined by the GOR algorithm. In some embodiments, the XTEN sequence may have at least about 80%, more preferably at least about 90%, more preferably at least about 91%, more preferably at least about 92%, more preferably at least about 93%, more preferably at least about 94%, More preferably at least about 95%, more preferably at least about 96%, more preferably at least about 97%, more preferably at least about 98%, and most preferably at least about 99% random coil, as determined by the GOR algorithm. net charge

In other cases, XTEN polypeptides may have unstructured features imparted by the incorporation of amino acid residues with a net charge and/or a reduction in the proportion of hydrophobic amino acids in the XTEN sequence. The overall net charge and net charge density can be controlled by adjusting the content of charged amino acids in the XTEN sequence. In some cases, the net charge density of the XTEN of the composition may be higher than +0.1 or lower than -0.1 charges/residue. In other cases, the XTEN can have a net charge of about 0%, about 1%, about 2%, about 3%, about 4%, about 5%, about 6%, about 7%, about 8%, about 9% , about 10%, about 11%, about 12%, about 13%, about 14%, about 15%, about 16%, about 17%, about 18%, about 19%, or about 20% or more.

Since most tissues and surfaces in humans or animals have a net negative charge, XTEN sequences can be designed to have a net negative charge to bridge the gap between XTEN-containing compositions and various surfaces such as blood vessels, healthy tissue, or various receptors. Non-specific interactions are minimized. Without being bound by a particular theory, XTEN may adopt an open conformation due to electrostatic repulsion between individual amino acids of the XTEN polypeptide, which individually carry a high net negative charge and are distributed throughout the XTEN polypeptide sequence. Such a distribution of net negative charges in the extended sequence length of XTEN can produce an unstructured conformation, which in turn can lead to an effective increase in hydrodynamic radius. Accordingly, in one embodiment, the invention provides XTEN, wherein the XTEN sequence contains about 8%, 10%, 15%, 20%, 25%, or even about 30% glutamic acid. The XTEN of the compositions of the invention generally have no or low levels of positively charged amino acids. In some cases, the XTEN can have less than about 10% positively charged amino acid residues, or less than about 7%, or less than about 5%, or less than about 2% positively charged amino acid residues. However, the present invention encompasses constructs in which a limited number of positively charged amino acids such as lysine can be incorporated into XTEN to allow the epsilon amine of lysine to interact with reactive groups, linker bridges on the peptide Or the combination between the reactive groups on the drug or small molecule, thus binding to the XTEN backbone. In the foregoing, a fusion protein comprising XTEN, a biologically active protein plus a chemotherapeutic agent useful in the treatment of a metabolic disease or disorder can be constructed, wherein the maximum number of molecules of the agent incorporated into the XTEN component is achieved by incorporation into the XTEN The number of lysine or other amino acids with reactive side chains (such as cysteine) can be determined.

In some cases, XTEN sequences may contain charged residues separated by other residues such as serine or glycine, which may lead to better performance or purification behavior. Based on net charge, the XTEN of the compositions of the invention may have an isoelectric point (pi) of 1.0, 1.5, 2.0, 2.5, 3.0, 3.5, 4.0, 4.5, 5.0, 5.5, 6.0, or even 6.5. In preferred embodiments, the XTEN will have an isoelectric point between 1.5 and 4.5. In these embodiments, the XTEN incorporated into the BPXTEN fusion protein compositions of the invention will carry a net negative charge under physiological conditions, which can contribute to the unstructured conformation and interaction of XTEN components with mammalian proteins and tissues Combined reduction.

Because hydrophobic amino acids can impart structure to polypeptides, the content of hydrophobic amino acids in XTEN provided by the present invention will generally be less than 5%, or less than 2%, or less than 1% hydrophobic amino acid content. In one embodiment, the amino acid content of methionine and tryptophan in the XTEN component of the BPXTEN fusion protein is generally less than 5%, or less than 2%, and most preferably less than 1%. In some embodiments, the XTEN will have less than 10% positively charged amino acid residues, or less than about 7%, or less than about 5%, or less than about 2% positively charged amino acid residues. In the sequence of bases, the sum of methionine and tryptophan residues will be less than 2%, and the sum of asparagine and glutamic acid residues will be less than 10% of the total XTEN sequence. Increased hydrodynamic radius

In some embodiments, the XTEN can have a high hydrodynamic radius, thereby conferring a corresponding increased apparent molecular weight on a BPXTEN fusion protein incorporating the XTEN. Linkage of XTEN to a BP sequence can result in a BPXTEN composition that can have increased hydrodynamic radius, increased apparent molecular weight, and increased apparent molecular weight factor compared to BP not linked to XTEN. For example, in therapeutic applications where extended half-life is desired, compositions in which XTEN with high hydrodynamic radii are incorporated into fusion proteins comprising one or more BPs can effectively amplify beyond approximately 3-5 nm The hydrodynamic radius of the composition of the glomerular pore size (corresponding to an apparent molecular weight of about 70 kDa) (Caliceti. 2003. Pharmacokinetic and biodistribution properties of poly(ethylene glycol)-protein conjugates. Adv. Drug Deliv. Rev. 55:1261-1277), thereby reducing the renal clearance of circulating proteins. The hydrodynamic radius of a protein is determined by its molecular weight as well as its structure, including shape and compactness. Without being bound by a particular theory, XTEN may adopt an open conformation due to electrostatic repulsion between individual charges of the peptide or inherent flexibility conferred by specific amino acids in the sequence that do not have secondary structure imparting properties. potential. The open, extended, and unstructured conformations of XTEN polypeptides can be of greater composition than polypeptides of comparable sequence length and/or molecular weight with secondary and/or tertiary structure, such as typical globular proteins. Scaled hydrodynamic radius. Methods of determining hydrodynamic radius are well known in the art, such as by using size exclusion chromatography (SEC), as described in US Patent Nos. 6,406,632 and 7,294,513. Addition of increasing lengths of XTEN results in a proportional increase in the parameters of hydrodynamic radius, apparent molecular weight and apparent molecular weight factor, allowing tuning of BPXTEN to have a desired characteristic cut-off apparent molecular weight or hydrodynamic radius. Thus, in certain embodiments, a BPXTEN fusion protein can be configured with XTEN such that the fusion protein can have an AA of at least about 5 nm, or at least about 8 nm, or at least about 10 nm, or 12 nm, or at least about 15 nm. The hydrodynamic radius of . In the foregoing examples, the large hydrodynamic radius conferred by XTEN in a BPXTEN fusion protein can result in reduced renal clearance of the resulting fusion protein, resulting in a correspondingly increased terminal half-life, increased mean residence time, and/or decreased renal clearance rate.

In some embodiments, an XTEN of selected length and sequence can be selectively incorporated into a BPXTEN to produce a BPXTEN that will have at least about 150 kDa, or at least about 300 kDa, or at least about 400 kDa, or at least About 500 kDa, or at least about 600 kDa, or at least about 700 kDa, or at least about 800 kDa, or at least about 900 kDa, or at least about 1000 kDa, or at least about 1200 kDa, or at least about 1500 kDa, or at least about 1800 kDa kDa, or at least about 2000 kDa, or at least about 2300 kDa or greater apparent molecular weight fusion protein. In some embodiments, XTEN having a selected length and sequence can be selectively linked to BP to produce at least three, alternatively at least four, alternatively at least five, alternatively at least six, alternatively at least BPXTEN fusion proteins of an apparent molecular weight factor of alternatively at least seven, alternatively at least eight, alternatively at least nine, alternatively at least 10, alternatively at least 15, or an apparent molecular weight factor of at least 20 or greater. In some embodiments, relative to the actual molecular weight of the fusion protein, the BPXTEN fusion protein has a molecular weight of about 4 to about 20, or about 6 to about 15, or about 8 to about 12, or about 9 to about 10 under physiological conditions. The apparent molecular weight factor. In some embodiments, the (fusion) polypeptide exhibits an apparent molecular weight factor greater than about 6 under physiological conditions. extended terminal half-life

In some embodiments, the (fusion) polypeptide has a terminal half-life that is at least two times longer, or at least three times longer, or at least four times longer, or at least five times longer than the biologically active polypeptide not linked to any XTEN. In some embodiments, the (fusion) polypeptide has a terminal half-life that is at least two-fold longer than the biologically active polypeptide not linked to any XTEN.

Administration of a therapeutically effective dose of any of the embodiments of the BPXTEN fusion proteins described herein to an individual in need thereof can result in a therapeutic effect of the fusion protein as compared to the corresponding BP not linked to XTEN and administered to the individual at a comparable dose. The time spent within the window is increased by at least two times, or at least three times, or at least four times, or at least five times or more. low immunogenicity

In some embodiments, the invention provides compositions wherein the XTEN sequences are less immunogenic or substantially non-immunogenic. Several factors may contribute to the low immunogenicity of XTEN, such as substantially non-repetitive sequence, unstructured conformation, high degree of solubility, low or no self-aggregation, low degree of proteolytic sites within the sequence Either have no proteolytic site and a low degree of epitope in the XTEN sequence or have no epitope.

Those of ordinary skill in the art will understand that, in general, highly repetitive short amino acid sequences (e.g., sequences of 200 amino acid lengths contain an average of 20 or more of a limited set of 3-mers or 4-mers) repeat sequences) and/or polypeptides with consecutively repeating amino acid residues (for example, where 5-mer or 6-mer sequences have identical amino acid residues) tend to aggregate or form higher-order structures or form contacts, resulting in crystallization or pseudocrystalline structure.

In some embodiments, the XTEN sequence is substantially non-repetitive, wherein (1) the XTEN sequence does not have three consecutive amino acids of the same amino acid type, unless the amino acid is serine, in which case No more than three consecutive amino acids may be serine residues; and wherein (2) the XTEN does not contain more than 16, more than 14, more than 12 or more than 10 times the 3-amino acid sequence (3-mer). Those of ordinary skill in the art will appreciate that such substantially non-repetitive sequences have a low tendency to aggregate and, therefore, enable the design of long-sequence XTENs with relatively low frequencies of charged amino acids if the sequence or amino acid residues If the base is more repetitive in other ways, the XTEN will likely aggregate.

A conformational epitope is formed by a region of the surface of a protein composed of multiple discrete amino acid sequences of the protein antigen. Precise folding of proteins brings these sequences into well-defined stable spatial configurations or epitopes that can be recognized as "foreign" by the host's humoral immune system, thereby eliciting the production of antibodies against the protein Or trigger a cell-mediated immune response. In the latter case, an individual's immune response to the protein is largely influenced by T cell epitope recognition, which varies with the peptide binding specificity of the individual's HLA-DR isotype. Engagement of cognate T cell receptors on the surface of T cells with MHC class II peptide complexes and cross-binding of certain other co-receptors such as CD4 molecules can induce an activated state within T cells. Activation causes the release of cytokines, which further activate other lymphocytes such as B cells to produce antibodies or activate T killer cells as part of a complete cellular immune response.

The ability of a peptide to bind a given MHC class II molecule for presentation on the surface of an APC (antigen presenting cell) depends on a number of factors; most notably its primary sequence. In one embodiment, a lower degree of immunogenicity can be achieved by designing XTEN sequences that resist antigen processing in antigen-presenting cells and/or selecting sequences that do not bind MHC receptors well. The present invention provides BPXTEN fusion proteins with substantially non-repetitive XTEN polypeptides that are designed to reduce binding to II MHC receptors and avoid formation of epitope or antibody binding to T cell receptors, resulting in greater Low degree of immunogenicity. Avoidance of immunogenicity is in part a direct result of the conformational flexibility of the XTEN sequences; that is, lack of secondary structure due to the choice and order of amino acid residues. For example, of interest are sequences that have a low propensity to adopt a tightly folded conformation in aqueous solution or under physiological conditions that can generate conformational epitopes. Administration of fusion proteins comprising XTEN using conventional therapeutic protocols and dosing generally does not result in the formation of neutralizing antibodies directed against the XTEN sequences, and may also reduce the immunogenicity of the BP fusion partner in BPXTEN compositions.

In one embodiment, the XTEN sequences used in the fusion proteins of the invention may be substantially free of epitopes recognized by human T cells. Elimination of such epitopes for the purpose of producing less immunogenic proteins has been previously disclosed; see for example WO 98/52976, WO 02/079232 and WO 00/3317, which are incorporated herein by reference middle. Analysis of human T cell epitopes has been described (Stickler, M. et al. (2003) J Immunol Methods , 281: 95-108). Of interest are peptide sequences that can oligomerize without generating T cell epitopes or non-human sequences. This can be eliminated by testing for the presence of T cell epitopes of direct repeats of these sequences and 6-mers to 15-mers and in particular non-human 9-mer sequences and then altering the design of the XTEN sequences to eliminate or This is achieved by disrupting the epitope sequence. In some instances, the XTEN sequences are substantially non-immunogenic by limiting the number of epitopes of the XTEN predicted to bind MHC receptors. As the number of epitopes capable of binding to MHC receptors is reduced, T cell activation potential and T cell helper functions are simultaneously reduced, B cell activation or upregulation is reduced, and antibody production is reduced. The low degree of predicted T cell epitopes can be determined by epitope prediction algorithms such as TEPITOPE (Sturniolo, T. et al. (1999) Nat Biotechnol, 17: 555-61), as described in International Patent Application Publication Shown in Example 74 of WO 2010/144502 A2, which is incorporated by reference in its entirety. The TEPITOPE score for a given peptide framework within a protein is the logarithm of the K _d (dissociation constant, affinity, dissociation rate) for binding of that peptide framework to several of the most common human MHC alleles, as described by Sturniolo, T. et al. (1999) Nature Biotechnology 17:555). The score ranges from about 10 to about -10 (corresponding to a binding limit of 10e ¹⁰ K _d to 10e ^{- 10} K _d ) in at least 20 logs, and the score can be reduced by avoiding hydrophobic amino acids, which Such hydrophobic amino acids, such as M, I, L, V or F, can serve as anchor residues during display of the peptide on the MHC. In some embodiments, the XTEN component incorporated into the BPXTEN does not have a TEPITOPE score of about -5 or greater, or -6 or greater, or -7 or greater, or -8 or greater, or a TEPITOPE score T cell epitopes predicted to be -9 or greater. A score of "-9 or greater" as used herein will cover TEPITOPE scores from 10 to -9 inclusive, but will not cover a score of -10 because -10 is less than -9.

In some embodiments, an XTEN sequence of the invention comprising an XTEN sequence incorporated into a BPXTEN fusion protein of the invention can reduce processing of XTEN to bind to MHC II receptors by restricting known proteolytic sites from the XTEN sequence Small peptides appear to be substantially non-immunogenic. In some embodiments, XTEN sequences can be rendered substantially non-immunogenic by using sequences substantially free of secondary structure, thereby conferring resistance to various proteases due to the high entropy of the structure. Thus, reducing the TEPITOPE score and eliminating known proteolytic sites from XTEN can render XTEN compositions including XTEN of BPXTEN fusion protein compositions substantially incapable of binding mammalian receptors, including receptors of the immune system. body. In one embodiment, the XTEN of the _BPXTEN fusion protein can have >100 nM Kd for binding to mammalian receptors, or greater than 500 nM _Kd or greater than 1 µM _Kd for binding to mammalian cell surface or circulating polypeptide receptors the combination.

In addition, the substantially non-repetitive sequences and corresponding epitope deficiency of these XTEN embodiments may limit the ability of B cells to bind to or be activated by XTEN. Although an XTEN can make contact with many different B cells on its extended sequence, each individual B cell can only make one or a small number of contacts with a single XTEN. Thus, XTEN may generally have a much lower propensity to stimulate B cell proliferation and thus immune response. In one embodiment, the BPXTEN may have reduced immunogenicity compared to the corresponding unfused BP. In one embodiment, administration of up to three parenteral doses of BPXTEN to a mammal produces detectable anti-BPXTEN IgG at a serum dilution of 1:100 but not at a dilution of 1:1000. In some embodiments, administration of up to three parenteral doses of BPXTEN to a mammal produces detectable anti-BP IgG at a serum dilution of 1:100 rather than at a 1:1000 dilution. In some embodiments, administration of up to three parenteral doses of BPXTEN to a mammal produces detectable anti-XTEN IgG at a serum dilution of 1:100 rather than at a 1:1000 dilution. In the foregoing embodiments, the mammal may be a mouse, a rat, a rabbit or a cynomolgus monkey.

An additional feature of certain embodiments of XTENs having substantially non-repetitive sequences relative to their less non-repetitive sequences (such as sequences having three identical consecutive amino acids) may be: Non-repetitive XTENs are associated with antibody formation Weaker contacts (eg, monovalent interactions), thereby making immune clearance less likely, allow BPXTEN compositions to remain in circulation for extended periods of time.

In some embodiments, the (fusion) polypeptide is less immunogenic than a biologically active polypeptide not linked to any XTEN, wherein immunogenicity is measured by selective binding to the biological The production of IgG antibodies to the active peptide was determined. spacer and BP release segment

In some embodiments, at least a portion of the biological activity of the respective BP is retained by the intact BPXTEN. In some embodiments, the BP component becomes biologically active or has increased biological activity after its release from the XTEN by cleavage of an optional cleavage sequence incorporated into the BPXTEN within the spacer sequence, as follows more complete description.

Any group of spacer sequences in fusion proteins encompassed by the invention is optional. Spacers can be provided to enhance host cell expression of the fusion protein or to reduce steric hindrance so that the BP component can assume its desired tertiary structure and/or interact appropriately with its target molecule. For spacers and methods of identifying the desired spacers, see, eg, George et al . (2003) Protein Engineering 15:871-879, which is specifically incorporated herein by reference. In one embodiment, the spacer comprises one or more amino acid residues between 1 and 50 amino acid residues in length or between about 1 and 25 residues in length or between about 1 and 10 residues in length. the peptide sequence. The spacer sequence excluding the cleavage site may comprise any of the 20 natural L amino acids, and will preferably comprise non-hindered hydrophilic amino acids which may include but It is not limited to glycine (G), alanine (A), serine (S), threonine (T), glutamic acid (E) or proline (P). In some cases, the spacer can be polyglycine or polyalanine, or a mixture of predominantly glycine and alanine residues in combination. Spacer polypeptides excluding the cleavage sequence will largely be substantially free of secondary structure. In one embodiment, one or both spacer sequences in the BPXTEN fusion protein composition may each further contain a cleavage sequence which may be the same or may be different, wherein the cleavage sequence acts to release the BP from the fusion protein by the action of a protease.

In some cases, the incorporation of cleavage sequences into the BPXTEN is designed to permit the release of BPs that become active or more active upon release of the BP from the XTEN. The cleavage sequence is positioned close enough to the BP sequence, typically within 18 amino acids, or within 12 amino acids, or within 6 amino acids, or within 2 amino acids of the end of the BP sequence, so that after cleavage Any remaining residues linked to BP do not significantly interfere with BP activity (eg, binding to a receptor), but are sufficiently accessible to proteases to enable cleavage of the cleavage sequence. In some embodiments, the cleavage site is a sequence that is cleavable by a protease endogenous to the mammalian subject such that the BPXTEN can be cleaved after administration to the subject. In such cases, BPXTEN can act as a pre-BP drive or circulating depot. Examples of cleavage sites encompassed by the present invention include, but are not limited to, cleavage sites that can be identified as FXIa, FXIIa, pancreatin, FVIIa, FIXa, FXa, FIIa (thrombin), elastase-2, granzyme B, MMP-12 , MMP-13, MMP-17, or MMP-20 are cleaved by endogenous mammalian proteases, or can be cleaved by non-mammalian proteases such as TEV, enterokinase, PreScission™ protease (rhinovirus 3C protease), and transpeptidase A the peptide sequence. Sequences known to be cleaved by the aforementioned proteases are known in the art. Exemplary cleavage sequences and cleavage sites within the sequences as well as sequence variants are presented in Table 7a . For example, thrombin (activated coagulation factor II) acts on the sequence LTPRSLLV (SEQ ID NO: 222) [Rawlings ND et al. (2008) Nucleic Acids Res. , 36 : D320], which would be at position 4 in the sequence It is cleaved after arginine. Active FIIa is produced by cleavage of FII by FXa in the presence of phospholipids and calcium and is downstream of Factor IX in the coagulation pathway. Once activated, its natural role in coagulation cleaves fibrinogen, which then initiates clot formation. FIIa activity is tightly controlled and occurs only when coagulation is necessary for proper hemostasis. However, since blood coagulation is a continuous process in mammals, by incorporating the LTPRSLLV (SEQ ID NO: 222) sequence into BPXTEN between BP and XTEN, the XTEN domain will be removed from the adjacent BP while physiologically BP is released over time by activation of the external or internal coagulation pathway when coagulation is required. Similarly, incorporation of other sequences into BPXTEN that acts by endogenous proteases will provide sustained release of BP, which in some cases may provide a higher degree of activity to BP from the "prodrug" form of BPXTEN.

In some cases, only two or three amino acids flanking the cleavage site (for a total of four to six amino acids) will be incorporated into the cleavage sequence. In other cases, the known cleavage sequence may have one or more deletions or insertions or one or two or three amino acid substitutions for any one or two or three amino acids in the known sequence, wherein the deletion The ability to tailor the rate of BP release from XTEN results from reduced or increased sensitivity to proteases, insertions or substitutions, rather than nonexistent. Exemplary substitutions are shown in Table 7a . Table 7a: Protease cleavage sequence for BP release sequence-acting protease SEQ ID NO Exemplary cleavage sequence SEQ ID NO Minimal Cutting Site * FXIa 224 KLTR↓VVGG 244 KD/FL/T/R↓VA/VE/GT/GV FXIIa 225 TMTR↓IVGG NA NA Pancreatin 226 SPFR↓STGG 245 -/-/FL/RY↓SR/RT/-/- FVIIa 227 LQVR↓IVGG NA NA FIXa 228 PLGR↓IVGG 247 -/-/G/R↓-/-/-/- FXa 229 IEGR↓TVGG 248 IA/E/GFP/R↓STI/VFS/-/G FIIa (thrombin) 230 LTPR↓SLLV 249 -/-/PLA/R↓SAG/-/-/- elastase-2 231 LGPV↓SGVP 250 -/-/-/VIAT↓-/-/-/- Granzyme-B 232 VAGD↓SLEE 251 V/-/-/D↓-/-/-/- MMP-12 233 GPAG↓LGGA 241 G/PA/-/G↓L/-/G/- (SEQ ID NO: 241) MMP-13 234 GPAG↓LRGA 242 G/P/-/G↓L/-/GA/- (SEQ ID NO: 242) MMP-17 235 APLG↓LRLR 252 -/PS/-/-↓LQ/-/LT/- MMP-20 236 PALP↓LVAQ NA NA TEV 237 ENLYFQ↓G 243 ENLYFQ↓/GS Enterokinase 238 DDDK↓IVGG 238 DDDK↓IVGG Protease 3C (PreScission ^™ ) 239 LEVLFQ↓GP 239 LEVLFQ↓GP transpeptidase A 240 LPKT↓GSES 246 L/P/KEAD/T↓G/-/EKS/S ↓ indicates the cleavage site; NA: not applicable; *A list of multiple amino acids before, between or after the slash indicates alternative amino acids that may be substituted at that position; "-" indicates that any amino acid is The corresponding amino acids indicated in the middle column can be substituted.

In some embodiments, a BXTEN fusion protein may comprise a spacer sequence, which may further comprise one or more cleavage sequences configured to self fuse upon the action of a protease Protein releases BP. In some embodiments, the one or more cleavage sequences may be at least about 80% (e.g., at least about 85%, at least about 90%, at least about 95%, at least about 96%, at least about 97%) identical to the sequence from Table 7a . %, at least about 98%, at least about 99%, or 100%) sequence identity.

In some embodiments, the invention provides BP release segment peptides (or release segment (RS)) that are receptors for one or more mammalian proteases associated with or produced by cells present in or near diseased tissue. quality. Such proteases may include, but are not limited to, protease classes such as metalloproteases, cysteine proteases, aspartic proteases, and serine proteases, including but not limited to the proteases of Table 7b . RSs are particularly suitable for incorporation into recombinant polypeptides of the invention, thereby conferring a prodrug format that can be activated by cleavage of the RS by mammalian proteases. As described herein, the RS is incorporated into the recombinant polypeptide compositions of the invention by linking the incorporated binding moiety to the XTEN (the configuration of which is described more fully below) such that in the presence of one or more of the substrates via the RS Upon cleavage of the RS by the action of the protease, the binding moiety and the XTEN are released from the composition and the binding moiety, which is no longer masked by the XTEN, regains its full potential to bind its ligand. Among those recombinant polypeptide compositions comprising the first antibody fragment and the second antibody fragment, such compositions are also referred to herein as activatable antibody compositions (AAC). Table 7b: Target cathepsins Protease class protease metalloprotease penetrating peptidase Neprilysin (CD10) PSMA BMP-1 Disintegrins and metalloproteinases (ADAMs) ADAM8 ADAM9 ADAM10 ADAM12 ADAM15 ADAM17 (TACE) ADAM19 ADAM28 (MDC-L) ADAM with thrombospondin motif (ADAMTS) ADAMTS1 ADAMTS4 ADAMTS5 Matrix Metalloproteinases (MMPs) MMP-1 (Collagenase 1) MMP-2 (gelatinase A) MMP-3 (m1) MMP-7 (matrilysin 1) MMP-8 (Collagenase 2) MMP-9 (Gelatinase B) MMP-10 (Stromelysin 2) MMP-11 (Stromelysin 3) MMP-12 (macrophage elastase) MMP-13 (Collagenase 3) MMP-14 (MT1-MMP) MMP-15 (MT2-MMP) MMP-19 MMP-23 (CA-MMP) MMP-24 (MT5-MMP) MMP-26 (Matrilysin 2) MMP-27 (CMMP) cysteine protease pod protein cysteine cathepsin Cathepsin B Cathepsin C Cathepsin K Cathepsin L Cathepsin S Cathepsin X Aspartic protease Cathepsin D Cathepsin E Secretase serine protease Urokinase (uPA) Tissue plasminogen activator (tPA) Plasmin thrombin Prostate-specific antigen (PSA, KLK3) Human Neutrophil Elastase (HNE) Elastase tryptase Type II transmembrane serine protease (TTSP) DESC1 Type II penetrating serine protease (HPN) interstitial protease interstitial proteinase-2 TMPRSS2 TMPRSS3 TMPRSS4 (CAP2) Fibroblast Activation Protein (FAP) Pancreatin-related peptidases (KLK family) KLK4 KLK5 KLK6 KLK7 KLK8 KLK10 KLK11 KLK13 KLK14

In one embodiment, the invention provides an activatable recombinant polypeptide comprising a first release segment (RS1) sequence which, when optimally aligned, is identified herein by the sequence set forth in Table 8a The sequences have at least 88%, or at least 94%, or 100% sequence identity, wherein RS1 is a substrate for one or more mammalian proteases. In other embodiments, the invention provides activatable recombinant polypeptides comprising RS1 and a second release segment (RS2) sequence, each of the RS1 and RS2 sequences when optimally aligned is set forth herein by Table 8a The identified sequences have at least 88%, or at least 94%, or 100% sequence identity, wherein each of RS1 and RS2 is a substrate for one or more mammalian proteases. In one embodiment, the invention provides an activatable recombinant polypeptide comprising a first RS (RS1) sequence which, when optimally aligned, has the same sequence as identified herein by the sequence set forth in Table 8b At least 90%, at least 93%, at least 97%, or 100% identity, wherein the RS is a substrate for one or more mammalian proteases. In other embodiments, the invention provides activatable recombinant polypeptides comprising RS1 and a second release segment (RS2) sequence, each of the RS1 and RS2 sequences when optimally aligned as set forth herein by Table 8b The sequence identified by the sequence has at least 88%, or at least 94%, or 100% sequence identity, wherein each of RS1 and RS2 is a substrate for one or more mammalian proteases (e.g., one of the , two or three cleavage sites). In embodiments of an activatable recombinant polypeptide comprising RS1 and RS2, the two release segments may be identical or the sequences may be different.

The invention contemplates the release segment as a substrate for one, two or three different classes of proteases, be it metalloproteases, cysteine proteases, aspartic proteases or serine proteases, including those of Table 7b Protease. In a particular feature, the RS acts as a substrate for proteases present in close association or co-localization with diseased tissues or cells such as but not limited to tumors, cancer cells, and inflammatory tissues, and upon cleavage of the RS, is otherwise mediated by the present invention The XTEN-masked (and thus lower binding affinity for its respective ligand) binding moieties of the recombinant polypeptide composition are released from the composition and regain their full potential to bind target and/or effector cell ligands. In some embodiments, the RS of the recombinant polypeptide composition of the present invention comprises an amino acid sequence serving as a substrate for a cellular protease located in the target cell, such cellular protease includes but not limited to the proteases in Table 7b . In another special feature of the recombinant polypeptide composition of the present invention, the RS serving as substrates for two or three classes of proteases is designed to have sequences capable of being cleaved by different proteases in different positions of the RS sequence. Thus, RSs that are substrates for two, three or more classes of proteases have two, three or multiple distinct cleavage sites in the RS sequence, but single protease cleavage still results in binding moieties and XTEN self-contained The recombinant polypeptide composition of RS is released.

In one embodiment, the RS of the present invention incorporated into the recombinant polypeptide composition of the present invention is the substrate of one or more proteases, including but not limited to penetrating peptidase, enkephalinase (CD10), PSMA, BMP-1, disintegrin and metalloproteinase (ADAM), ADAM8, ADAM9, ADAM10, ADAM12, ADAM15, ADAM17 (TACE), ADAM19, ADAM28 (MDC-L), ADAM with thrombospondin motif (ADAMTS ), ADAMTS1, ADAMTS4, ADAMTS5, MMP-1 (collagenase 1), matrix metalloproteinase-1 (MMP-1), matrix metalloproteinase-2 (MMP-2, gelatinase A), matrix metalloproteinase-3 (MMP -3, stromelysin 1), matrix metalloproteinase-7 (MMP-7, stromelysin 1), matrix metalloproteinase-8 (MMP-8, collagenase 2), matrix metalloproteinase-9 (MMP-9, Gelatinase B), matrix metalloproteinase-10 (MMP-10, stromelysin 2), matrix metalloproteinase-11 (MMP-11, stromelysin 3), matrix metalloproteinase-12 (MMP-12, macrophage Elastase), matrix metalloproteinase-13 (MMP-13, collagenase 3), matrix metalloproteinase-14 (MMP-14, MT1-MMP), matrix metalloproteinase-15 (MMP-15, MT2-MMP), matrix Metalloproteinase-19 (MMP-19), matrix metalloproteinase-23 (MMP-23, CA-MMP), matrix metalloproteinase-24 (MMP-24, MT5-MMP), matrix metalloproteinase-26 (MMP-26, stromelysin 2), matrix metalloproteinase-27 (MMP-27, CMMP), pod protein, cathepsin B, cathepsin C, cathepsin K, cathepsin L, cathepsin S, cathepsin X, cathepsin D, Cathepsin E, secretase, urokinase (uPA), tissue plasminogen activator (tPA), plasmin, thrombin, prostate-specific antigen (PSA, KLK3), human neutrophil elastin Protease (HNE), Elastase, Tryptase, Type II Transmembrane Serine Protease (TTSP), DESC1, Type II Penetrating Serine Protease (HPN), Interstitial Protease, Interstitial Protease-2, TMPRSS2 , TMPRSS3, TMPRSS4 (CAP2), fibroblast activation protein (FAP), pancreatin-related peptidase (KLK family), KLK4, KLK5, KLK6, KLK7, KLK8, KLK10, KLK11, KLK13 and KLK14. In one embodiment, RS is a substrate for ADAM17. In one embodiment, RS is a substrate for BMP-1. In one embodiment, RS is a substrate for cathepsin. In one embodiment, RS is a substrate for HtrA1. In one embodiment, RS is a substrate for pod protein. In one embodiment, RS is a substrate for MMP-1. In one embodiment, RS is a substrate for MMP-2. In one embodiment, RS is a substrate for MMP-7. In one embodiment, RS is a substrate for MMP-9. In one embodiment, RS is a substrate for MMP-11. In one embodiment, RS is a substrate for MMP-14. In one embodiment, RS is a substrate for uPA. In one embodiment, RS is a substrate for interstitial proteases. In one embodiment, RS is a substrate for MT-SP1. In one embodiment, RS is a substrate for neutrophil elastase. In one embodiment, RS is a substrate for thrombin. In one embodiment, RS is a substrate for TMPRSS3. In one embodiment, RS is a substrate for TMPRSS4. In one embodiment, the RS of the recombinant polypeptide composition of the present invention is the substrate of at least two proteases, including but not limited to pod protein, MMP-1, MMP-2, MMP-7, MMP-9, MMP -11, MMP-14, uPA and interstitial proteases. In some embodiments, the RS of the recombinant polypeptide composition of the present invention is the substrate of pod protein, MMP-1, MMP-2, MMP-7, MMP-9, MMP-11, MMP-14, uPA and interstitial protease . Table 8a: BP release segment sequence. name Construct ID amino acid sequence SEQ ID NO RSR-1517 AC1611 EAGRSANHEPLGLVAT 7001 BSRS-A1-1 AC1605 ASGRSTNAGPSGLAGP 7002 BSRS-A2-1 AC1606 ASGRSTNAGPQGLAGQ 7003 BSRS-A3-1 AC1607 ASGRSTNAGPPGLTGP 7004 VP-1 AC1608 ASSRGTNAGPAGLTGP 7005 RSR-1752 AC1609 ASSRTTNTGPSTLTGP 7006 RSR-1512 AC1610 AAGRSDNGTPLEVAP 7007 RSR-1517 AC1611 EAGRSANHEPLGLVAT 7008 VP-2 AC1612 ASGRGTNAGPAGLTGP 7009 RSR-1018 AC1613 LFGRNDNHEPLEGGG 7010 RSR-1053 AC1614 TAGRSDNLEPLGLVFG 7011 RSR-1059 AC1615 LDGRSDNFHPPELVAG 7012 RSR-1065 AC1616 LEGRSDNEEPENLVAG 7013 RSR-1167 AC1617 LKGRSDNAPLALVAG 7014 RSR-1201 AC1618 VYSRGTNAGPHGLTGR 7015 RSR-1218 AC1619 ANSRGTNKGFAGLIGP 7016 RSR-1226 AC1620 ASSRLTNEAPAGLTIP 7017 RSR-1254 AC1621 DQSRGTNAGPEGLTDP 7018 RSR-1256 AC1622 ESSRGTNIGQGGLTGP 7019 RSR-1261 AC1623 SSSRGTNQDPAGLTIP 7020 RSR-1293 AC1624 ASSRGQNHSPMGLTGP 7021 RSR-1309 AC1625 AYSRGPNAGPAGLEGR 7022 RSR-1326 AC1626 ASERGN NAGP ANLTGF 7023 RSR-1345 AC1627 ASHRGTNPKPAILTGP 7024 RSR-1354 AC1628 MSSRRTNANPAQLTGP 7025 RSR-1426 AC1629 GAGRTDNHEPLELGAA 7026 RSR-1478 AC1630 LAGRSENTAPLELTAG 7027 RSR-1479 AC1631 LEGRPDN HEPLALVAS 7028 RSR-1496 AC1632 LSGRSDNEEPLALPAG 7029 RSR-1508 AC1633 EAGRTDNHEPLELSAP 7030 RSR-1513 AC1634 EGGRSDNHGPLELVSG 7031 RSR-1516 AC1635 LSGRSDNEAPLELEAG 7032 RSR-1524 AC1636 LGGRADNHEPPELGAG 7033 RSR-1622 AC1637 PPSRGTNAEPAGLTGE 7034 RSR-1629 AC1638 ASTRGENAGPAGLEAP 7035 RSR-1664 AC1639 ESSRGTNGAPEGLTGP 7036 RSR-1667 AC1640 ASSRATNESPAGLTGE 7037 RSR-1709 AC1641 ASSRGENPPGGLTGP 7038 RSR-1712 AC1642 AASRGTNTGPAELTGS 7039 RSR-1727 AC1643 AGSRTTNAGPGGLEGP 7040 RSR-1754 AC1644 APSRGENAGPATLTGA 7041 RSR-1819 AC1645 ESGRAANTGPPTLTAP 7042 RSR-1832 AC1646 NPGRAANEGPPPGLPGS 7043 RSR-1855 AC1647 ESSRAANLTPPELTGP 7044 RSR-1911 AC1648 ASGRAANETPPGLTGA 7045 RSR-1929 AC1649 NSGRGENLGAPGLTGT 7046 RSR-1951 AC1650 TTGRAANLTPAGLTGP 7047 RSR-2295 AC1761 EAGRSANHTPAGLTGP 7048 RSR-2298 AC1762 ESGRAANT PAGLTGP 7049 RSR-2038 AC1679 TTGRATEAANLTPAGLTGP 7050 RSR-2072 AC1680 TTGRAEEAANLTPAGLTGP 7051 RSR-2089 AC1681 TTGRAGEAANLTPAGLTGP 7052 RSR-2302 AC1682 TTGRATEAANATPAGLTGP 7053 RSR-3047 AC1697 TTGRAGEAEGATSAGATGP 7054 RSR-3052 AC1698 TTGEAGEAANATSAGATGP 7055 RSR-3043 AC1699 TTGEAGEAAGLTPAGLTGP 7056 RSR-3041 AC1700 TTGAAGEAANATPAGLTGP 7057 RSR-3044 AC1701 TTGRAGEAAGLTPAGLTGP 7058 RSR-3057 AC1702 TTGRAGEAANATSAGATGP 7059 RSR-3058 AC1703 TTGEAGEAAGATSAGATGP 7060 RSR-2485 AC1763 ESGRAANTEPPELGAG 7061 RSR-2486 AC1764 ESGRAANTA PEG LTGP 7062 RSR-2488 AC1688 EPGRAAN HEPSGLTEG 7063 RSR-2599 AC1706 ESGRAANHTGAPPGGLTGP 7064 RSR-2706 AC1716 TTGRTGEGANATPGGLTGP 7065 RSR-2707 AC1717 RTGRSGEAANETPEGLEGP 7066 RSR-2708 AC1718 RTGRTGESANETPAGLGGP 7067 RSR-2709 AC1719 STGRTGEPANETPAGLSGP 7068 RSR-2710 AC1720 TTGRAGEPANATPTGLSGP 7069 RSR-2711 AC1721 RTGRPGEGANATPTGLPGP 7070 RSR-2712 AC1722 RTGRGGEAANATPSGLGGP 7071 RSR-2713 AC1723 STGRSGESANATPGGLGGP 7072 RSR-2714 AC1724 RTGRTGEEANATPAGLPGP 7073 RSR-2715 AC1725 ATGRPGEPANTTPEGLEGP 7074 RSR-2716 AC1726 STGRSGEPANATPGGLTGP 7075 RSR-2717 AC1727 PTGRGGEGANTTPTGLPGP 7076 RSR-2718 AC1728 PTGRSGEGANATPSGLTGP 7077 RSR-2719 AC1729 TTGRASEGANSTPAPLTEP 7078 RSR-2720 AC1730 TYGRAAEAANTTPAGLTAP 7079 RSR-2721 AC1731 TTGRATEGANATPAELTEP 7080 RSR-2722 AC1732 TVGRASEEANTTPASLTGP 7081 RSR-2723 AC1733 TTGRAPEAANATPAPLTGP 7082 RSR-2724 AC1734 TWGRATEPANATPAPLTSP 7083 RSR-2725 AC1735 TVGRASESANATPAELTSP 7084 RSR-2726 AC1736 TVGRAPEGANSTPAGLTGP 7085 RSR-2727 AC1737 TWGRATEAPNLEPATLTTP 7086 RSR-2728 AC1738 TTGRATEAPNLTPALTEP 7087 RSR-2729 AC1739 TQGRATEAPNLSPAALTSP 7088 RSR-2730 AC1740 TQGRAAEAPNLTPATLTAP 7089 RSR-2731 AC1741 TSGRAPEATNLAPAPLTGP 7090 RSR-2732 AC1742 TQGRAAEAANLTPAGLTEP 7091 RSR-2733 AC1743 TTGRAGSAPNLPPTGLTTP 7092 RSR-2734 AC1744 TTGRAGGAENLPPEGLTAP 7093 RSR-2735 AC1745 TTSRAGTATNLTPEGLTAP 7094 RSR-2736 AC1746 TTGRAGTATNLPPSGLTTP 7095 RSR-2737 AC1747 TTARAGEAENLSPSGLTAP 7096 RSR-2738 AC1748 TTGRAGGAGNLAPGGLTEP 7097 RSR-2739 AC1749 TTGRAGTATNLPPEGLTGP 7098 RSR-2740 AC1750 TTGRAGGAANLAPTGLTEP 7099 RSR-2741 AC1751 TTGRAGTAENLAPSGLTTP 7100 RSR-2742 AC1752 TTGRAGSATNLPGGGLTGP 7101 RSR-2743 AC1753 TTARAGGAENLTPAGLTEP 7102 RSR-2744 AC1754 TTARAGSAENLSPSGLTGP 7103 RSR-2745 AC1755 TTARAGGAGNLAPEGLTTP 7104 RSR-2746 AC1756 TTSRAGAAENLTPTGLTGP 7105 RSR-2747 AC1757 TYGRTTTTPGNEPPASLEAE 7106 RSR-2748 AC1758 TYSRGESGPNEPPPGLTGP 7107 RSR-2749 AC1759 AWGRTGASENETPAPLGGE 7108 RSR-2750 AC1760 RWGRAETTP NTPPEGLETE 7109 RSR-2751 AC1765 ESGRAANHTGAEPPELGAG 7110 RSR-2754 AC1801 TTGRAGEAANLTPAGLTES 7111 RSR-2755 AC1802 TTGRAGEAANLTPAALTES 7112 RSR-2756 AC1803 TTGRAGEAANLTPAPLTES 7113 RSR-2757 AC1804 TTGRAGE AANLTPEPLTES 7114 RSR-2758 AC1805 TTGRAGEAANLTPAGLTGA 7115 RSR-2759 AC1806 TTGRAGEAANLTPEGLTGA 7116 RSR-2760 AC1807 TTGRAGEAANLTPEPLTGA 7117 RSR-2761 AC1808 TTGRAGEAANLTPAGLTEA 7118 RSR-2762 AC1809 TTGRAGEAANLTPEGLTEA 7119 RSR-2763 AC1810 TTGRAGEAANLTPAPLTEA 7120 RSR-2764 AC1811 TTGRAGEAANLTPEPLTEA 7121 RSR-2765 AC1812 TTGRAGEAANLTPEPLTGP 7122 RSR-2766 AC1813 TTGRAGEAANLTPAGLTGG 7123 RSR-2767 AC1814 TTGRAGEAANLTPEGLTGG 7124 RSR-2768 AC1815 TTGRAGEAANLTPEALTGG 7125 RSR-2769 AC1816 TTGRAGEAANLTPEPLTGG 7126 RSR-2770 AC1817 TTGRAGEAANLTPAGLTEG 7127 RSR-2771 AC1818 TTGRAGEAANLTPEGLTEG 7128 RSR-2772 AC1819 TTGRAGEAANLTPAPLTEG 7129 RSR-2773 AC1820 TTGRAGEAANLTPEPLTEG 7130 Table 8b: Release Segment Sequence name amino acid sequence SEQ ID NO: name amino acid sequence SEQ ID NO: RSN-0001 GSAPGSAGGYAELRMGGAIATSGSETPGT 7131 RSC-0001 GTAEAASASGGSAGGYAELRMGGAIPGSP 7379 RSN-0002 GSAPGTGGGYAPLRMGGGAATSGSETPGT 7132 RSC-0002 GTAEAASASGGTGGGYAPLRMGGGAPGSP 7380 RSN-0003 GSAPGAEGGYAALRMGGEIATSGSETPGT 7133 RSC-0003 GTAEAASASGGAEGGYAALRMGGEIPGSP 7381 RSN-0004 GSAPGGPGGYALLRMGGPAATSGSETPGT 7134 RSC-0004 GTAEAASASGGGPGGYALLRMGGPAPGSP 7382 RSN-0005 GSAPGEAGGYAFLRMGGSIATSGSETPGT 7135 RSC-0005 GTAEAASASGGEAGGYAFLRMGGSIPGSP 7383 RSN-0006 GSAGPPGGGYASLRMGGTAATSGSETPGT 7136 RSC-0006 GTAEAASASGGPGGGYASLRMGGTAPGSP 7384 RSN-0007 GSAPGSEGGYATLRMGGAIATSGSETPGT 7137 RSC-0007 GTAEAASASGGSEGGYATLRMGGAIPGSP 7385 RSN-0008 GSAPGTPGGYANLRMGGGAATSGSETPGT 7138 RSC-0008 GTAEAASASGGTPGGYANLRMGGGAPGSP 7386 RSN-0009 GSAPGASGGYAHLRMGGEIATSGSETPGT 7139 RSC-0009 GTAEAASASGGASGGYAHLRMGGEIPGSP 7387 RSN-0010 GSAPGGTGGYGELRMGGPAATSGSETPGT 7140 RSC-0010 GTAEAASASGGGTGGYGELRMGGPAPGSP 7388 RSN-0011 GSAPGEAGGYPELRMGGSIATSGSETPGT 7141 RSC-0011 GTAEAASASGGEAGGYPELRMGGSIPGSP 7389 RSN-0012 GSAGPPGGGYVELRMGGTAATSGSETPGT 7142 RSC-0012 GTAEAASASGGPGGGYVELRMGGTAPGSP 7390 RSN-0013 GSAPGSEGGYLELRMGGAIATSGSETPGT 7143 RSC-0013 GTAEAASASGGSEGGYLELRMGGAIPGSP 7391 RSN-0014 GSAPGTPGGYSELRMGGGAATSGSETPGT 7144 RSC-0014 GTAEAASASGGTPGGYSELRMGGGAPGSP 7392 RSN-0015 GSAPGASGGYTELRMGGEIATSGSETPGT 7145 RSC-0015 GTAEAASASGGASGGYTELRMGGEIPGSP 7393 RSN-0016 GSAPGGTGGYQELRMGGPAATSGSETPGT 7146 RSC-0016 GTAEAASASGGGTGGYQELRMGGPAPGSP 7394 RSN-0017 GSAPGEAGGYEELRMGGSIATSGSETPGT 7147 RSC-0017 GTAEAASASGGEAGGYEELRMGGSIPGSP 7395 RSN-0018 GSAGPPGIGPAELRMGGTAATSGSETPGT 7148 RSC-0018 GTAEAASASGGPGIGPAELRMGGTAPGSP 7396 RSN-0019 GSAPGSEIGAAELRMGGAIATSGSETPGT 7149 RSC-0019 GTAEAASASGGSEIGAAELRMGGAIPGSP 7397 RSN-0020 GSAPGTPIGSAELRMGGGAATSGSETPGT 7150 RSC-0020 GTAEAASASGGTPIGSAELRMGGGAPGSP 7398 RSN-0021 GSAPGASIGTAELRMGGEIATSGSETPGT 7151 RSC-0021 GTAEAASASGGASIGTAELRMGGEIPGSP 7399 RSN-0022 GSAPGGTIGNAELRMGGPAATSGSETPGT 7152 RSC-0022 GTAEAASASGGGTIGNAELRMGGPAPGSP 7400 RSN-0023 GSAPGEAIGQAELRMGGSIATSGSETPGT 7153 RSC-0023 GTAEAASASGGEAIGQAELRMGGSIPGSP 7401 RSN-0024 GSAGPPGGPYAELRMGGTAATSGSETPGT 7154 RSC-0024 GTAEAASASGGPGGPYAELRMGGTAPGSP 7402 RSN-0025 GSAPGSEGAYAELRMGGAIATSGSETPGT 7155 RSC-0025 GTAEAASASGGSEGAYAELRMGGAIPGSP 7403 RSN-0026 GSAPGTPGVYAELRMGGGAATSGSETPGT 7156 RSC-0026 GTAEAASASGGTPGVYAELRMGGGAPGSP 7404 RSN-0027 GSAPGASGLYAELRMGGEIATSGSETPGT 7157 RSC-0027 GTAEAASASGGASGLYAELRMGGEIPGSP 7405 RSN-0028 GSAPGGTGIYAELRMGGPAATSGSETPGT 7158 RSC-0028 GTAEAASASGGGTGIYAELRMGGPAPGSP 7406 RSN-0029 GSAPAGEAGFYAELRMGGSIATSGSETPGT 7159 RSC-0029 GTAEAASASGGEAGFYAELRMGGSIPGSP 7407 RSN-0030 GSAGPPGGYYAELRMGGTAATSGSETPGT 7160 RSC-0030 GTAEAASASGGPGGYYAELRMGGTAPGSP 7408 RSN-0031 GSAPGSEGSYAELRMGGAIATSGSETPGT 7161 RSC-0031 GTAEAASASGGSEGSYAELRMGGAIPGSP 7409 RSN-0032 GSAPGTPGNYAELRMGGGAATSGSETPGT 7162 RSC-0032 GTAEAASASGGTPGNYAELRMGGGAPGSP 7410 RSN-0033 GSAPGASGEYAELRMGGEIATSGSETPGT 7163 RSC-0033 GTAEAASASGGASGEYAELRMGGEIPGSP 7411 RSN-0034 GSAPGGTGHYAELRMGGPAATSGSETPGT 7164 RSC-0034 GTAEAASASGGGTGHYAELRMGGPAPGSP 7412 RSN-0035 GSAPGEAGGYAEARMGGSIATSGSETPGT 7165 RSC-0035 GTAEAASASGGEAGGYAEARMGGSIPGSP 7413 RSN-0036 GSAGPPGGGYAEVRMGGTAATSGSETPGT 7166 RSC-0036 GTAEAASASGGPGGGYAEVRMGGTAPGSP 7414 RSN-0037 GSAPGSEGGYAEIRMGGAIATSGSETPGT 7167 RSC-0037 GTAEAASASGGSEGGYAEIRMGGAIPGSP 7415 RSN-0038 GSAPGTPGGYAEFRMGGGAATSGSETPGT 7168 RSC-0038 GTAEAASASGGTPGGYAEFRMGGGAPGSP 7416 RSN-0039 GSAPGASGGYAEYRMGGEIATSGSETPGT 7169 RSC-0039 GTAEAASASGGASGGYAEYRMGGEIPGSP 7417 RSN-0040 GSAPGGTGGYAESRMGGPAATSGSETPGT 7170 RSC-0040 GTAEAASASGGGTGGYAESRMGGPAPGSP 7418 RSN-0041 GSAPGEAGGYAETRMGGSIATSGSETPGT 7171 RSC-0041 GTAEAASASGGEAGGYAETRMGGSIPGSP 7419 RSN-0042 GSAGPPGGGYAELAMGGTRATSGSETPGT 7172 RSC-0042 GTAEAASASGGPGGGYAELAMGGTRPGSP 7420 RSN-0043 GSAPGSEGGYAELVMGGARATSGSETPGT 7173 RSC-0043 GTAEAASASGGSEGGYAELVMGGARPGSP 7421 RSN-0044 GSAPGTPGGYAELLMGGGRATSGSETPGT 7174 RSC-0044 GTAEAASASGGTPGGYAELLMGGGRPGSP 7422 RSN-0045 GSAPGASGGYAELIMGGERATSGSETPGT 7175 RSC-0045 GTAEAASASGGASGGYAELIMGGERPGSP 7423 RSN-0046 GSAPGGTGGYAELWMGGPRATSGSETPGT 7176 RSC-0046 GTAEAASASGGGTGGYAELWMGGPRPGSP 7424 RSN-0047 GSAPGEAGGYAELSMGGSRATSGSETPGT 7177 RSC-0047 GTAEAASASGGEAGGYAELSMGGSRPGSP 7425 RSN-0048 GSAGPPGGGYAELTMGGTRATSGSETPGT 7178 RSC-0048 GTAEAASASGGPGGGYAELTMGGTRPGSP 7426 RSN-0049 GSAPGSEGGYAELQMGGARATSGSETPGT 7179 RSC-0049 GTAEAASASGGSEGGYAELQMGGARPGSP 7427 RSN-0050 GSAPGTPGGYAELNMGGGRATSGSETPGT 7180 RSC-0050 GTAEAASASGGTPGGYAELNMGGGRPGSP 7428 RSN-0051 GSAPGASGGYAELEMGGERATSGSETPGT 7181 RSC-0051 GTAEAASASGGASGGYAELEMGGERPGSP 7429 RSN-0052 GSAPGGTGGYAELRPGGPIATSGSETPGT 7182 RSC-0052 GTAEAASASGGGTGGYAELRPGGPIPPGSP 7430 RSN-0053 GSAPGEAGGYAELRAGGSAATSGSETPGT 7183 RSC-0053 GTAEAASASGGEAGGYAELRAGGSAPGSP 7431 RSN-0054 GSAGPPGGGYAELRLGGTIATSGSETPGT 7184 RSC-0054 GTAEAASASGGPGGGYAELRLGGTIPGSP 7432 RSN-0055 GSAPGSEGGYAELRIGGAAATSGSETPGT 7185 RSC-0055 GTAEAASASGGSEGGYAELRIGGAAPGSP 7433 RSN-0056 GSAPGTPGGYAELRSGGGIATSGSETPGT 7186 RSC-0056 GTAEAASASGGTPGGYAELRSGGGIPGSP 7434 RSN-0057 GSAPGASGGYAELRNGGEAATSGSETPGT 7187 RSC-0057 GTAEAASASGGASGGYAELRNGGEAPGSP 7435 RSN-0058 GSAPGGTGGYAELRQGGPIATSGSETPGT 7188 RSC-0058 GTAEAASASGGGTGGYAELRQGGPIPGSP 7436 RSN-0059 GSAPGEAGGYAELRDGGSAATSGSETPGT 7189 RSC-0059 GTAEAASASGGEAGGYAELRDGGSAPGSP 7437 RSN-0060 GSAGPPGGGYAELREGGTIATSGSETPGT 7190 RSC-0060 GTAEAASASGGPGGGYAELREGGTIPGSP 7438 RSN-0061 GSAPGSEGGYAELRHGGAAATSGSETPGT 7191 RSC-0061 GTAEAASASGGSEGGYAELRHGGAAPGSP 7439 RSN-0062 GSAPGTPGGYAELRMPGGIATSGSETPGT 7192 RSC-0062 GTAEAASASGGTPGGYAELRMPGGIPGSP 7440 RSN-0063 GSAPGASGGYAELRMAGEAATSGSETPGT 7193 RSC-0063 GTAEAASASGGASGGYAELRMAGEAPGSP 7441 RSN-0064 GSAPGGTGGYAELRMVGPIATSGSETPGT 7194 RSC-0064 GTAEAASASGGGTGGYAELRMVGPIPGSP 7442 RSN-0065 GSAPGEAGGYAELRMGLGSAATSGSETPGT 7195 RSC-0065 GTAEAASASGGEAGGYAELRMGLGSAPGSP 7443 RSN-0066 GSAGPPGGGYAELRMIGTIATSGSETPGT 7196 RSC-0066 GTAEAASASGGPGGGYAELRMIGTIPGSP 7444 RSN-0067 GSAPGSEGGYAELRMYGAIATSGSETPGT 7197 RSC-0067 GTAEAASASGGSEGGYAELRMYGAIPGSP 7445 RSN-0068 GSAPGTPGGYAELRMSGGAATSGSETPGT 7198 RSC-0068 GTAEAASASGGTPGGYAELRMSGGAPGSP 7446 RSN-0069 GSAPGASGGYAELRMNGEIATSGSETPGT 7199 RSC-0069 GTAEAASASGGASGGYAELRMNGEIPGSP 7447 RSN-0070 GSAPGGTGGYAELRMQGPAATSGSETPGT 7200 RSC-0070 GTAEAASASGGGTGGYAELRMQGPAPGSP 7448 RSN-0071 GSAPGANHTPAGLTGPGARATSGSETPGT 7201 RSC-0071 GTAEAASASGGANHTPAGLTGPGARPGSP 7449 RSN-0072 GSAPGANTAPEGLTGPSTRATSGSETPGT 7202 RSC-0072 GTAEAASASGGANTAPEGLTGPSTRPGSP 7450 RSN-0073 GSAPGTGAPPGGLTGPGTRATSGSETPGT 7203 RSC-0073 GTAEAASASGGTGAPPGGLTGPGTRPGSP 7451 RSN-0074 GSAPGANHEPSGLTEGSPRATSGSETPGT 7204 RSC-0074 GTAEAASASGGANHEPSGLTEGSPRPGSP 7452 RSN-0075 GSAPGANTEPPELGAGTERATSGSETPGT 7205 RSC-0075 GTAEAASASGGANTEPPELGAGTERPGSP 7453 RSN-0076 GSAPGASGPPPGLTGPPGRATSGSETPGT 7206 RSC-0076 GTAEAASASGGASGPPPGLTGPPGRPGSP 7454 RSN-0077 GSAPGASGTPAPLGGEPGRATSGSETPGT 7207 RSC-0077 GTAEAASASGGASGTPAPLGGEPGRPGSP 7455 RSN-0078 GSAPGPAGPPPEGLETEAGRATSGSETPGT 7208 RSC-0078 GTAEAASASGGPAGPPEGLETEAGRPGSP 7456 RSN-0079 GSAPGPTSGQGGLTGPESRATSGSETPGT 7209 RSC-0079 GTAEAASASGGPTSGQGGLTGPESRPGSP 7457 RSN-0080 GSAPGSAGGAANLVRGGAIATSGSETPGT 7210 RSC-0080 GTAEAASASGGSAGGAANLVRGGAIPGSP 7458 RSN-0081 GSAPGTGGGAAPLVRGGGAATSGSETPGT 7211 RSC-0081 GTAEAASASGGTGGGAAPLVRGGGAPGSP 7459 RSN-0082 GSAPGAEGGAAALVRGGEIATSGSETPGT 7212 RSC-0082 GTAEAASASGGAEGGAAALVRGGEIPGSP 7460 RSN-0083 GSAPGGPGGAALLVRGGPAATSGSETPGT 7213 RSC-0083 GTAEAASASGGGPGGAALLVRGGPAPGSP 7461 RSN-0084 GSAPGEAGGAAFLVRGGSIATSGSETPGT 7214 RSC-0084 GTAEAASASGGEAGGAAFLVRGGSIPGSP 7462 RSN-0085 GSAGPPGGGAASLVRGGTAATSGSETPGT 7215 RSC-0085 GTAEAASASGGPGGGAASLVRGGTAPGSP 7463 RSN-0086 GSAPGSEGGAATLVRGGAIATSGSETPGT 7216 RSC-0086 GTAEAASASGGSEGGAATLVRGGAIPGSP 7464 RSN-0087 GSAPGTPGGAAGLVRGGGAATSGSETPGT 7217 RSC-0087 GTAEAASASGGTPGGAAGLVRGGGAPGSP 7465 RSN-0088 GSAPGASGGAADLVRGGEIATSGSETPGT 7218 RSC-0088 GTAEAASASGGASGGAADLVRGGEIPGSP 7466 RSN-0089 GSAPGGTGGAGNLVRGGPAATSGSETPGT 7219 RSC-0089 GTAEAASASGGGTGGAGNLVRGGPAPGSP 7467 RSN-0090 GSAPGEAGGAPNLVRGGSIATSGSETPGT 7220 RSC-0090 GTAEAASASGGEAGGAPNLVRGGSIPGSP 7468 RSN-0091 GSAGPPGGGAVNLVRGGTAATSGSETPGT 7221 RSC-0091 GTAEAASASGGPGGGAVNLVRGGTAPGSP 7469 RSN-0092 GSAPGSEGGALNLVRGGAIATSGSETPGT 7222 RSC-0092 GTAEAASASGGSEGGALNLVRGGAIPGSP 7470 RSN-0093 GSAPGTPGGASNLVRGGGAATSGSETPGT 7223 RSC-0093 GTAEAASASGGTPGGASNLVRGGGAPGSP 7471 RSN-0094 GSAPGASGGATNLVRGGEIATSGSETPGT 7224 RSC-0094 GTAEAASASGGASGGATNLVRGGEIPGSP 7472 RSN-0095 GSAPGGTGGAQNLVRGGPAATSGSETPGT 7225 RSC-0095 GTAEAASASGGGTGGAQNLVRGGPAPGSP 7473 RSN-0096 GSAPGEAGGAENLVRGGSIATSGSETPGT 7226 RSC-0096 GTAEAASASGGEAGGAENLVRGGSIPGSP 7474 RSN-1517 GSAPEAGRSANHEPLGLVATATSGSETPGT 7227 RSC-1517 GTAEAASASGEAGRSANHEPLGLVATPGSP 7475 BSRS-A1-2 GSAPASGRSTNAGPSGLAGPATSGSETPGT 7228 BSRS-A1-3 GTAEAASASGASGRSTNAGPSGLAGPPGSP 7476 BSRS-A2-2 GSAPASGRSTNAGPQGLAGQATSGSETPGT 7229 BSRS-A2-3 GTAEAASASGASGRSTNAGPQGLAGQPGSP 7477 BSRS-A3-2 GSAPASGRSTNAGPPGLTGPATSGSETPGT 7230 BSRS-A3-3 GTAEAASASGASGRSTNAGPPGLTGPPGSP 7478 VP-1 GSAPASSRGTNAGPAGLTGPATSGSETPGT 7231 VP-1 GTAEAASASGASSRGTNAGPAGLTGPPGSP 7479 RSN-1752 GSAPASSRTNTNTGPSTLTGPATSGSETPGT 7232 RSC-1752 GTAEAASASGASSRTTNTGPSTLTGPPGSP 7480 RSN-1512 GSAPAAGRSDNGTPLELVAPATSGSETPGT 7233 RSC-1512 GTAEAASASGAAGRSDNGTPLELVAPPPGSP 7481 RSN-1517 GSAPEAGRSANHEPLGLVATATSGSETPGT 7234 RSC-1517 GTAEAASASGEAGRSANHEPLGLVATPGSP 7482 VP-2 GSAPASGRGTNAGPAGLTGPATSGSETPGT 7235 VP-2 GTAEAASASGASGRGTNAGPAGLTGPPGSP 7483 RSN-1018 GSAPLFGRNDNHEPLEGGGGATSGSETPGT 7236 RSC-1018 GTAEAASASGLFGRNDNHEPLEGGGPGSP 7484 RSN-1053 GSAPTAGRSDNLEPLGLVFGATSGSETPGT 7237 RSC-1053 GTAEAASASGTAGRSDNLEPLGLVFGPGSP 7485 RSN-1059 GSAPLDGRSDNFHPPELVAGATSGSETPGT 7238 RSC-1059 GTAEAASASGLDGRSDNFHPPELVAGPGSP 7486 RSN-1065 GSAPLEGRSDNEEPENLVAGATSGSETPGT 7239 RSC-1065 GTAEAASASGLEGRSDNEEPENLVAGPGSP 7487 RSN-1167 GSAPLKGRSDNAPLALVAGATSGSETPGT 7240 RSC-1167 GTAEAASASGLKGRSDNAPLALVAGPGSP 7488 RSN-1201 GSAPVYSRGTNAGPHGLTGRATSGSETPGT 7241 RSC-1201 GTAEAASASGVYSRGTNAGPHGLTGRPGSP 7489 RSN-1218 GSAPANSRGTNKGFAGLIGPATSGSETPGT 7242 RSC-1218 GTAEAASASGANSRGTNKGFAGLIGPPGSP 7490 RSN-1226 GSAPASSRLTNEAPAGLTIPATSGSETPGT 7243 RSC-1226 GTAEAASASGASSRLTNEAPAGLTIPPGSP 7491 RSN-1254 GSAPDQSRGTNAGPEGLTDPATSGSETPGT 7244 RSC-1254 GTAEAASASGDQSRGTNAGPEGLTDPPGSP 7492 RSN-1256 GSAPESSRGTNIGQGGLTGPATSGSETPGT 7245 RSC-1256 GTAEAASASGESSRGTNIGQGGLTGPPGSP 7493 RSN-1261 GSAPSSSSRGTNQDPAGLTIPATSGSETPGT 7246 RSC-1261 GTAEAASASGSSSRGTNQDPAGLTIPPGSP 7494 RSN-1293 GSAPASSRGQNHSPMGLTGPATSGSETPGT 7247 RSC-1293 GTAEAASASGASSRGQNHSPMGLTGPPGSP 7495 RSN-1309 GSAPAYSRGPNAGPAGLEGRATSGSETPGT 7248 RSC-1309 GTAEAASASGAYSRGPNAGPAGLEGRPGSP 7496 RSN-1326 GSAPASERGNNAGPANLTGFATSGSETPGT 7249 RSC-1326 GTAEAASASGASERGNNAGPANLTGFPGSP 7497 RSN-1345 GSAPASHRGTNPKPAILTGPATSGSETPGT 7250 RSC-1345 GTAEAASASGASHRGTNPKPAILTGPPGSP 7498 RSN-1354 GSAPMSSRRTNANPAQLTGPATSGSETPGT 7251 RSC-1354 GTAEAASASGMSSRRTNANPAQLTGPPGSP 7499 RSN-1426 GSAPGAGRTDNHEPLELGAAATSGSETPGT 7252 RSC-1426 GTAEAASASGGAGRTDNHEPLELGAAPGSP 7500 RSN-1478 GSAPLAGRSENTAPLELTAGATSGSETPGT 7253 RSC-1478 GTAEAASASGLAGRSENTAPLELTAGPGSP 7501 RSN-1479 GSAPLEGRPDNHEPLALVASATSGSETPGT 7254 RSC-1479 GTAEAASASGLEGRPDNHEPLALVASPGSP 7502 RSN-1496 GSAPLSGRSDNEEPLALPAGATSGSETPGT 7255 RSC-1496 GTAEAASASGLSGRSDNEEPLALPAGSPGSP 7503 RSN-1508 GSAPEAGRTDNHEPLELSAPATSGSETPGT 7256 RSC-1508 GTAEAASASGEAGRTDNHEPLELSAPPGSP 7504 RSN-1513 GSAPEGGRSDNHGPLELVSGATSGSETPGT 7257 RSC-1513 GTAEAASASGEGGRSDNHGPLELVSGPGSP 7505 RSN-1516 GSAPLSGRSDNEAPLEEAGATSGSETPGT 7258 RSC-1516 GTAEAASASGLSGRSDNEAPLELEAGPGSP 7506 RSN-1524 GSAPLGGRADNHEPPELGAGATSGSETPGT 7259 RSC-1524 GTAEAASASGLGGRADNHEPPELGAGPGSP 7507 RSN-1622 GSAPPPSRGTNAEPAGLTGEATSGSETPGT 7260 RSC-1622 GTAEAASASGPPSRGTNAEPAGLTGEPGSP 7508 RSN-1629 GSAPASTRGENAGPAGLEAPATSGSETPGT 7261 RSC-1629 GTAEAASASGASTRGENAGPAGLEAPPGSP 7509 RSN-1664 GSAPESSRGTNGAPEGLTGPATSGSETPGT 7262 RSC-1664 GTAEAASASGESSRGTNGAPEGLTGPPGSP 7510 RSN-1667 GSAPASSRATNESPAGLTGEATSGSETPGT 7263 RSC-1667 GTAEAASASGASSRATNESPAGLTGEPGSP 7511 RSN-1709 GSAPASSRGENPPPGGLTGPATSGSETPGT 7264 RSC-1709 GTAEAASASGASSRGENPPGGLTGPPGSP 7512 RSN-1712 GSAPAASRGTNTGPAELTGSATSGSETPGT 7265 RSC-1712 GTAEAASASGAASRGTNTGPAELTGSPGSP 7513 RSN-1727 GSAPAGSRTTNAGPGGLEGPATSGSETPGT 7266 RSC-1727 GTAEAASASGAGSRTTNAGPGGLEGPPGSP 7514 RSN-1754 GSAPAPSRGENAGPATLTGAATSGSETPGT 7267 RSC-1754 GTAEAASASGAPSRGENAGPATLTGAPGSP 7515 RSN-1819 GSAPESGRAANTGPPTLTAPATSGSETPGT 7268 RSC-1819 GTAEAASASGESGRAANTGPPPTLTAPPGSP 7516 RSN-1832 GSANPPGRAANEGPPGLPGSATSGSETPGT 7269 RSC-1832 GTAEAASASGNPGRAANEGPPGLPGSPGSP 7517 RSN-1855 GSAPESSRAANLTPPELTGPATSGSETPGT 7270 RSC-1855 GTAEAASASGESSRAANLTPPELTGPPGSP 7518 RSN-1911 GSAPASGRAANETPPGLTGAATSGSETPGT 7271 RSC-1911 GTAEAASASGASGRAANETPPGLTGAPGSP 7519 RSN-1929 GSAPNSGRGENLGAPGLTGTATSGSETPGT 7272 RSC-1929 GTAEAASASGNSGRGENLGAPGLTGTPGSP 7520 RSN-1951 GSAPTTGRAANLTPAGLTGPATSGSETPGT 7273 RSC-1951 GTAEAASASGTTGRAANLTPAGLTGPPGSP 7521 RSN-2295 GSAPEAGRSANHTPAGLTGPATSGSETPGT 7274 RSC-2295 GTAEAASASGEAGRSANHTPAGLTGPPGSP 7522 RSN-2298 GSAPESGRAANTTPAGLTGPATSGSETPGT 7275 RSC-2298 GTAEAASASGESGRAANTTPAGLTGPPGSP 7523 RSN-2038 GSAPTTGRATEAANLTPAGLTGPATSGSETPGT 7276 RSC-2038 GTAEAASASGTTGRATEAANLTPAGLTGPPGSP 7524 RSN-2072 GSAPTTGRAEEAANLTPAGLTGPATSGSETPGT 7277 RSC-2072 GTAEAASASGTTGRAEEAANLTPAGLTGPPGSP 7525 RSN-2089 GSAPTTGRAGEAANLTPAGLTGPATSGSETPGT 7278 RSC-2089 GTAEAASASGTTGRAGEAANLTPAGLTGPPGSP 7526 RSN-2302 GSAPTTGRATEAANATPAGLTGPATSGSETPGT 7279 RSC-2302 GTAEAASASGTTGRATEAANATPAGLTGPPGSP 7527 RSN-3047 GSAPTTGRAGEAEGATSAGATGPATSGSETPGT 7280 RSC-3047 GTAEAASASGTTGRAGEAEGATSAGATGPPGSP 7528 RSN-3052 GSAPTTGEAGEAANATSAGATGPATSGSETPGT 7281 RSC-3052 GTAEAASASGTTGEAGEAANATSAGATGPPGSP 7529 RSN-3043 GSAPTTGEAGEAAGLTPAGLTGPATSGSETPGT 7282 RSC-3043 GTAEAASASGTTGEAGEAAGLTPAGLTGPPGSP 7530 RSN-3041 GSAPTTGAAGEAANATPAGLTGPATSGSETPGT 7283 RSC-3041 GTAEAASASGTTGAAGEAANATPAGLTGPPGSP 7531 RSN-3044 GSAPTTGRAGEAAGLTPAGLTGPATSGSETPGT 7284 RSC-3044 GTAEAASASGTTGRAGEAAGLTPAGLTGPPGSP 7532 RSN-3057 GSAPTTGRAGEAANATSAGATGPATSGSETPGT 7285 RSC-3057 GTAEAASASGTTGRAGEAANATSAGATGPPGSP 7533 RSN-3058 GSAPTTGEAGEAAGATSAGATGPATSGSETPGT 7286 RSC-3058 GTAEAASASGTTGEAGEAAGATSAGATGPPGSP 7534 RSN-2485 GSAPESGRAANTEPPELGAGATSGSETPGT 7287 RSC-2485 GTAEAASASGESGRAANTEPPELGAGPGSP 7535 RSN-2486 GSAPESGRAANTAPEGLTGPATSGSETPGT 7288 RSC-2486 GTAEAASASGESGRAANTAPEGLTGPPGSP 7536 RSN-2488 GSAPEPGRAANHEPSGLTEGATSGSETPGT 7289 RSC-2488 GTAEAASASGEPGRAANHEPSGLTEGPGSP 7537 RSN-2599 GSAPESGRAANHTGAPPGGLTGPATSGSETPGT 7290 RSC-2599 GTAEAASASGESGRAANHTGAPPGGLTGPPGSP 7538 RSN-2706 GSAPTTGRTGEGANATPGGLTGPATSGSETPGT 7291 RSC-2706 GTAEAASASGTTGRTGEGANATPGGLTGPPGSP 7539 RSN-2707 GSAPRTGRSGEAANETPEGLEGPATSGSETPGT 7292 RSC-2707 GTAEAASASGRTGRSGEAANETPEGLEGPPGSP 7540 RSN-2708 GSAPRTGRTGESANETPAGLGGPATSGSETPGT 7293 RSC-2708 GTAEAASASGRTGRTGESANETPAGLGGPPGSP 7541 RSN-2709 GSAPSTGRTGEPANETPAGLSGPATSGSETPGT 7294 RSC-2709 GTAEAASASGSTGRTGEPANETPAGLSGPPGSP 7542 RSN-2710 GSAPTTGRAGEPANATPTGLSGPATSGSETPGT 7295 RSC-2710 GTAEAASASGTTGRAGEPANATPTGLSGPPGSP 7543 RSN-2711 GSAPRTGRPGEGANATPTGLPGPATSGSETPGT 7296 RSC-2711 GTAEAASASGRTGRPGEGANATPTGLPGPPGSP 7544 RSN-2712 GSAPRTGRGGEAANATPSGLGGPATSGSETPGT 7297 RSC-2712 GTAEAASASGRTGRGGEAANATPSGLGGPPGSP 7545 RSN-2713 GSAPSTGRSGESANATPGGLGGPATSGSETPGT 7298 RSC-2713 GTAEAASASGSTGRSGESANATPGGLGGPPGSP 7546 RSN-2714 GSAPRTGRTGEEANATPAGLPATSGSETPGT 7299 RSC-2714 GTAEAASASGRTGRTGEEANATPAGLPGPPGSP 7547 RSN-2715 GSAPATGRPGEPANTTPEGLEGPATSGSETPGT 7300 RSC-2715 GTAEAASASGATGRPGEPANTTPEGLEGPPGSP 7548 RSN-2716 GSAPSTGRSGEPANATPGGLTGPATSGSETPGT 7301 RSC-2716 GTAEAASASGSTGRSGEPANATPGGLTGPPGSP 7549 RSN-2717 GSAPPTGRGGEGANTTPTGLPGPATSGSETPGT 7302 RSC-2717 GTAEAASASGPTGRGGEGANTTPTGLPGPPGSP 7550 RSN-2718 GSAPPTGRSGEGANATPSGLTGPATSGSETPGT 7303 RSC-2718 GTAEAASASGPTGRSGEGANATPSGLTGPPGSP 7551 RSN-2719 GSAPTTGRASEGANSTPALTEPATSGSETPGT 7304 RSC-2719 GTAEAASASGTTGRASEGANSTPAPLTPPGSP 7552 RSN-2720 GSAPTYGRAAEAANTTPAGLTAPATSGSETPGT 7305 RSC-2720 GTAEAASASGTYGRAAEAANTTPAGLTAPPGSP 7553 RSN-2721 GSAPTTGRATEGANATPAELTEPATSGSETPGT 7306 RSC-2721 GTAEAASASGTTGRATEGANATPAELTEPPGSP 7554 RSN-2722 GSAPTVGRASEEANTTPASLTGPATSGSETPGT 7307 RSC-2722 GTAEAASASGTVGRASEEANTTPASLTGPPGSP 7555 RSN-2723 GSAPTTGRAPEAANTPAPLTGPATSGSETPGT 7308 RSC-2723 GTAEAASASGTTGRAPEAANATPAPLTGPPGSP 7556 RSN-2724 GSAPTWGRATEPANATPAPLTSPATSGSETPGT 7309 RSC-2724 GTAEAASASGTWGRATEPANATPAPLTSPPGSP 7557 RSN-2725 GSAPTVGRASESANATPAELTSPATSGSETPGT 7310 RSC-2725 GTAEAASASGTVGRASESANATPAELTSPPGSP 7558 RSN-2726 GSAPTVGRAPEGANSTPAGLTGPATSGSETPGT 7311 RSC-2726 GTAEAASASGTVGRAPEGANSTPAGLTGPPGSP 7559 RSN-2727 GSAPTWGRATEAPNLEPATLTTPATSGSETPGT 7312 RSC-2727 GTAEAASASGTWGRATEAPNLEPATLTTTPPGSP 7560 RSN-2728 GSAPTTGRATEAPNLTPAPLTEPATSGSETPGT 7313 RSC-2728 GTAEAASASGTTGRATEAPNLTPAPLTEPPGSP 7561 RSN-2729 GSAPTQGRATEAPNLSPAALTSPATSGSETPGT 7314 RSC-2729 GTAEAASASGTQGRATEAPNLSPAALTSPPGSP 7562 RSN-2730 GSAPTQGRAAEAPNLTPATLTAPATSGSETPGT 7315 RSC-2730 GTAEAASASGTQGRAAEAPNLTPATLTAPPPGSP 7563 RSN-2731 GSAPTSGRAPEATNLAPAPLTGPATSGSETPGT 7316 RSC-2731 GTAEAASASGTSGRAPEATNLAPAPLTGPPGSP 7564 RSN-2732 GSAPTQGRAAEAANLTPAGLTEPATSGSETPGT 7317 RSC-2732 GTAEAASASGTQGRAAEAANLTPAGLTEPPGSP 7565 RSN-2733 GSAPTTGRAGSAPNLPPTGLTTPATSGSETPGT 7318 RSC-2733 GTAEAASASGTTGRAGSAPNLPPTGLTTPPGSP 7566 RSN-2734 GSAPTTGRAGGAENLPPEGLTAPATSGSETPGT 7319 RSC-2734 GTAEAASASGTTGRAGGAENLPPEGLTAPPGSP 7567 RSN-2735 GSAPTTSRAGTATNLTPEGLTAPATSGSETPGT 7320 RSC-2735 GTAEAASASGTTSRAGTATNLTPEGLTAPPGSP 7568 RSN-2736 GSAPTTGRAGTATNLPPSGLTTPATSGSETPGT 7321 RSC-2736 GTAEAASASGTTGRAGTATNLPPSGLTTTPPGSP 7569 RSN-2737 GSAPTTARAGEAENLSPSGLTAPATSGSETPGT 7322 RSC-2737 GTAEAASASGTTARAGEAENLSPSGLTAPPPGSP 7570 RSN-2738 GSAPTTGRAGGAGNLAPGGLTEPATSGSETPGT 7323 RSC-2738 GTAEAASASGTTGRAGGAGNLAPGGLTEPPGSP 7571 RSN-2739 GSAPTTGRAGTATNLPPEGLTGPATSGSETPGT 7324 RSC-2739 GTAEAASASGTTGRAGTATNLPPEGLTGPPGSP 7572 RSN-2740 GSAPTTGRAGGAANLAPTGLTEPATSGSETPGT 7325 RSC-2740 GTAEAASASGTTGRAGGAANLAPTGLTEPPGSP 7573 RSN-2741 GSAPTTGRAGTAENLAPSGLTTPATSGSETPGT 7326 RSC-2741 GTAEAASASGTTGRAGTAENLAPSGLTTPPGSP 7574 RSN-2742 GSAPTTGRAGSATNLPGGGLTGPATSGSETPGT 7327 RSC-2742 GTAEAASASGTTGRAGSATNLPGGGLTGPPGSP 7575 RSN-2743 GSAPTTARAGGAENLTPAGLTEPATSGSETPGT 7328 RSC-2743 GTAEAASASGTTARAGGAENLTPAGLTEPPGSP 7576 RSN-2744 GSAPTTARAGSAENLSPSGLTGPATSGSETPGT 7329 RSC-2744 GTAEAASASGTTARAGSAENLSPSGLTGPPGSP 7577 RSN-2745 GSAPTTARAGGAGNLAPEGLTTPATSGSETPGT 7330 RSC-2745 GTAEAASASGTTARAGGAGNLAPEGLTTPPGSP 7578 RSN-2746 GSAPTTSRAGAAENLTPTGLTGPATSGSETPGT 7331 RSC-2746 GTAEAASASGTTSRAGAAENLTPTGLTGPPGSP 7579 RSN-2747 GSAPTYGRTTTPGNEPPASLEAEATSGSETPGT 7332 RSC-2747 GTAEAASASGTYGRTTTTPGNEPPASLEAEPGSP 7580 RSN-2748 GSAPTYSRGESGPNEPPPGLTGPATSGSETPGT 7333 RSC-2748 GTAEAASASGTYSRGESGPNEPPPGLTGPPGSP 7581 RSN-2749 GSAPAWGRTGASENETPAPLGGEATSGSETPGT 7334 RSC-2749 GTAEAASASGAWGRTGASENETPAPLGGEPGSP 7582 RSN-2750 GSAPRWGRAETTPNTPPEGLETEATSGSETPGT 7335 RSC-2750 GTAEAASASGRWGRAETTPNTPPEGLETEPGSP 7583 RSN-2751 GSAPESGRAANHTGAEPPELGAGATSGSETPGT 7336 RSC-2751 GTAEAASASGESGRAANHTGAEPPELGAPGGSP 7584 RSN-2754 GSAPTTGRAGEAANLTPAGLTESATSGSETPGT 7337 RSC-2754 GTAEAASASGTTGRAGEAANLTPAGLTESPGSP 7585 RSN-2755 GSAPTTGRAGEAANLTPAALTESATSGSETPGT 7338 RSC-2755 GTAEAASASGTTGRAGEAANLTPAALTESPGSP 7586 RSN-2756 GSAPTTGRAGEAANLTPAPLTESATSGSETPGT 7339 RSC-2756 GTAEAASASGTTGRAGEAANLTPAPLTESPGSP 7587 RSN-2757 GSAPTTGRAGEAANLTPEPLTESATSGSETPGT 7340 RSC-2757 GTAEAASASGTTGRAGEAANLTPEPLTESPGSP 7588 RSN-2758 GSAPTTGRAGEAANLTPAGLTGAATSGSETPGT 7341 RSC-2758 GTAEAASASGTTGRAGEAANLTPAGLTGAPGSP 7589 RSN-2759 GSAPTTGRAGEAANLTPEGLTGAATSGSETPGT 7342 RSC-2759 GTAEAASASGTTGRAGEAANLTPEGLTGAPGSP 7590 RSN-2760 GSAPTTGRAGEAANLTPEPLTGAATSGSETPGT 7343 RSC-2760 GTAEAASASGTTGRAGEAANLTPEPLTGAPGSP 7591 RSN-2761 GSAPTTGRAGEAANLTPAGLTEAATSGSETPGT 7344 RSC-2761 GTAEAASASGTTGRAGEAANLTPAGLTEAPGSP 7592 RSN-2762 GSAPTTGRAGEAANLTPEGLTEAATSGSETPGT 7345 RSC-2762 GTAEAASASGTTGRAGEAANLTPEGLTEAPGSP 7593 RSN-2763 GSAPTTGRAGEAANLTPAPLTEAATSGSETPGT 7346 RSC-2763 GTAEAASASGTTGRAGEAANLTPAPLTEAPGSP 7594 RSN-2764 GSAPTTGRAGEAANLTPEPLTEAATSGSETPGT 7347 RSC-2764 GTAEAASASGTTGRAGEAANLTPEPLTEAPGSP 7595 RSN-2765 GSAPTTGRAGEAANLTPEPLTGPATSGSETPGT 7348 RSC-2765 GTAEAASASGTTGRAGEAANLTPEPLTGPPGSP 7596 RSN-2766 GSAPTTGRAGEAANLTPAGLTGGATSGSETPGT 7349 RSC-2766 GTAEAASASGTTGRAGEAANLTPAGLTGGPGSP 7597 RSN-2767 GSAPTTGRAGEAANLTPEGLTGGATSGSETPGT 7350 RSC-2767 GTAEAASASGTTGRAGEAANLTPEGLTGGPGSP 7598 RSN-2768 GSAPTTGRAGEAANLTPEALTGGATSGSETPGT 7351 RSC-2768 GTAEAASASGTTGRAGEAANLTPEALTGGPGSP 7599 RSN-2769 GSAPTTGRAGEAANLTPEPLTGGATSGSETPGT 7352 RSC-2769 GTAEAASASGTTGRAGEAANLTPEPLTGGPGSP 7600 RSN-2770 GSAPTTGRAGEAANLTPAGLTEGATSGSETPGT 7353 RSC-2770 GTAEAASASGTTGRAGEAANLTPAGLTEGPGSP 7601 RSN-2771 GSAPTTGRAGEAANLTPEGLTEGATSGSETPGT 7354 RSC-2771 GTAEAASASGTTGRAGEAANLTPEGLTEGPGSP 7602 RSN-2772 GSAPTTGRAGEAANLTPAPLTEGATSGSETPGT 7355 RSC-2772 GTAEAASASGTTGRAGEAANLTPAPLTEGPGSP 7603 RSN-2773 GSAPTTGRAGEAANLTPEPLTEGATSGSETPGT 7356 RSC-2773 GTAEAASASGTTGRAGEAANLTPEPLTEGPGSP 7604 RSN-3047 GSAPTTGRAGEAEGATSAGATGPATSGSETPGT 7357 RSC-3047 GTAEAASASGTTGRAGEAEGATSAGATGPPGSP 7605 RSN-2783 GSAPEAGRSAEATSAGATGPATSGSETPGT 7358 RSC-2783 GTAEAASASGEAGRSAEATSAGATGPPGSP 7606 RSN-3107 GSAPSASGTYSRGESGPGSPATSGSETPGT 7359 RSC-3107 GTAEAASASGSASGTYSRGESGPGSPPGSP 7607 RSN-3103 GSAPSASGEAGRTDTHPGSPATSGSETPGT 7360 RSC-3103 GTAEAASASGSASGEAGRTDTHPGSPPGSP 7608 RSN-3102 GSAPSASGEPGRAAEHPGSPATSGSETPGT 7361 RSC-3102 GTAEAASASGSASGEPGRAAEHPGSPPGSP 7609 RSN-3119 GSAPSPAGESSRGTTIAGSPATSGSETPGT 7362 RSC-3119 GTAEAASASGSPAGESSRGTTIAGSPPPGSP 7610 RSN-3043 GSAPTTGEAGEAAGLTPAGLTGPATSGSETPGT 7363 RSC-3043 GTAEAASASGTTGEAGEAAGLTPAGLTGPPGSP 7611 RSN-2789 GSAPEAGESAGATPAGLTGPATSGSETPGT 7364 RSC-2789 GTAEAASASGEAGESAGATPAGLTGPPGSP 7612 RSN-3109 GSAPSASGAPLELEAGPGSPATSGSETPGT 7365 RSC-3109 GTAEAASASGSASGAPLELEAGPGSPPGSP 7613 RSN-3110 GSAPSASGEPPELGAGPGSPATSGSETPGT 7366 RSC-3110 GTAEAASASGSASGEPPELGAGPGSPPPGSP 7614 RSN-3111 GSAPSASGEPSGLTEGPGSPATSGSETPGT 7367 RSC-3111 GTAEAASASGSASGEPSGLTEGPGSPPPGSP 7615 RSN-3112 GSAPSASGTPAPLTEPPGSPATSGSETPGT 7368 RSC-3112 GTAEAASASGSASGTPAPLTEPPGSPPGSP 7616 RSN-3113 GSAPSASGTPAELTEPPGSPATSGSETPGT 7369 RSC-3113 GTAEAASASGSASGTPAELTEPPGSPPGSP 7617 RSN-3114 GSAPSASGPPPGLTGPPGSPATSGSETPGT 7370 RSC-3114 GTAEAASASGSASGPPPGLTGPPGSPPGSP 7618 RSN-3115 GSAPSASGTPAPLGGEPGSPATSGSETPGT 7371 RSC-3115 GTAEAASASGSASGTPAPLGGEPGSPPGSP 7619 RSN-3125 GSAPSPAGAPEGLTGPAGSPATSGSETPGT 7372 RSC-3125 GTAEAASASGSPAGAPEGLTGPAGSPPGSP 7620 RSN-3126 GSAPSPAGPPEGLETEAGSPATSGSETPGT 7373 RSC-3126 GTAEAASASGSPAGPPEGLETEAGSPPGSP 7621 RSN-3127 GSAPSPTSGQGGLTGPGSEPATSGSETPGT 7374 RSC-3127 GTAEAASASGSPTSGQGGLTGPGSEPPGSP 7622 RSN-3131 GSAPSEAPPEGLETESTEPATSGSETPGT 7375 RSC-3131 GTAEAASASGSSEAPPEGLETESTEPPGSP 7623 RSN-3132 GSAPSEGSEPLELGAASETPATSGSETPGT 7376 RSC-3132 GTAEAASASGSEGSEPLELGAASETPPGSP 7624 RSN-3133 GSAPSEGSGPAGLEAPSETPATSGSETPGT 7377 RSC-3133 GTAEAASASGSEGSGPAGLEAPSETPPGSP 7625 RSN-3138 GSAPSEPTPPASLEAEPGSPATSGSETPGT 7378 RSC-3138 GTAEAASASGSSEPTPASLEAEPGSPPPGSP 7626

In some embodiments, RSs incorporated into recombinant polypeptides of the invention can be designed to be selectively sensitive to have different cleavage rates and different cleavage efficiencies for the various proteases for which they are substrates. Since a given protease may be present in different concentrations in diseased tissues including but not limited to tumors, blood cancers or inflamed tissues or sites of inflammation compared to healthy tissues or in the circulation, the present invention provides RSs that make individual amino acid sequences Engineered to have a higher or lower cleavage efficiency for a given protease compared to the rate of cleavage of RS in healthy tissue or circulation to ensure that the recombinant polypeptide is preferentially cleaved from the precursor in proximity to the target cell or tissue and its co-localized protease The drug form is converted to the active form (i.e., by separating and releasing the binding moiety and XTEN from the recombinant polypeptide after RS cleavage), so that the released antibody fragment binding moiety is more active than the pre-drug form remaining in circulation. Great ability to bind to ligands in diseased tissue. By such selective design, the therapeutic index of the resulting composition can be improved, causing fewer side effects relative to conventional therapeutic agents that do not incorporate this site-specific activation.

。因此，-1之裂解效率意謂與對照受質之量相比，測試裂解受質之量為50%，而+1之裂解效率意謂與對照受質之量相比，測試裂解受質之量為200%。測試蛋白酶相對於對照而言更高的裂解速率將引起更高的裂解效率，且測試蛋白酶相對於對照而言更慢的裂解速率將引起更低的裂解效率。如實例中所詳述，當在 活體外生物化學分析中測試個別蛋白酶之裂解速率時，具有胺基酸序列EAGRSANHEPLGLVAT (SEQ ID NO: 7001)之對照RS序列AC1611 (RSR-1517)經確立為具有適當基線的蛋白酶豆莢蛋白、MMP-2、MMP-7、MMP-9、MMP-14、uPA及間質蛋白酶裂解效率。藉由RS肽中之個別位置處之選擇性胺基酸取代，創建RS文庫且針對7種蛋白酶組進行評估(更完整地詳述於實例中)，從而產生用於為適當胺基酸取代建立指南以便達成具有所需裂解效率之RS的概況。在製造具有所需裂解效率之RS中，使用親水性胺基酸A、E、G、P、S及T進行之取代為較佳的，然而，其他L-胺基酸可在給定位置經取代以調整裂解效率，只要RS對於蛋白酶裂解保留至少一些易感性即可。用於保留或實現活性之肽中之保守胺基酸取代完全在熟習此項技術者之知識及能力內。在一個實施例中，本發明提供RS，其中在 活體外生物化學競爭性分析中，與具備具有序列EAGRSANHEPLGLVAT (SEQ ID NO. 7001)之對照序列RSR-1517的相同蛋白酶裂解相比，RS以高至少0.2 log ₂或0.4 log ₂或0.8 log ₂或1.0 log ₂之裂解效率經蛋白酶裂解，該蛋白酶包括但不限於豆莢蛋白、MMP-1、MMP-2、MMP-7、MMP-9、MMP-11、MMP-14、uPA或間質蛋白酶。在一些實施例中，本發明提供RS，其中在 活體外生物化學競爭性分析中，與具備具有序列EAGRSANHEPLGLVAT (SEQ ID NO. 7001)之對照序列RSR-1517的相同蛋白酶裂解相比，RS以低至少0.2 log ₂或0.4 log ₂或0.8 log ₂或1.0 log ₂之裂解效率經蛋白酶裂解，該蛋白酶包括但不限於豆莢蛋白、MMP-1、MMP-2、MMP-7、MMP-9、MMP-11、MMP-14、uPA或間質蛋白酶。在一個實施例中，本發明提供RS，其中與具有序列EAGRSANHEPLGLVAT (SEQ ID NO. 7001)之對照序列RSR-1517相比，RS之蛋白酶裂解速率快至少2倍、或至少4倍、或至少8倍、或至少16倍，該蛋白酶包括但不限於豆莢蛋白、MMP-1、MMP-2、MMP-7、MMP-9、MMP-11、MMP-14、uPA或間質蛋白酶。在一些實施例中，本發明提供RS，其中與具有序列EAGRSANHEPLGLVAT (SEQ ID NO. 7001)之對照序列RSR-1517相比，RS之蛋白酶裂解速率慢至少2倍、或至少4倍、或至少8倍、或至少16倍，該蛋白酶包括但不限於豆莢蛋白、MMP-1、MMP-2、MMP-7、MMP-9、MMP-11、MMP-14、uPA或間質蛋白酶。 Cleavage efficiency as used herein is defined as the test substrate comprising cleavage RS when each of the test substrate comprising cleavage RS and the control substrate cleavage AC1611 are subjected to a protease (further detailed in the Examples) in a biochemical assay performing the reaction. The log ₂ value of the ratio of the percentage of substrate to the percentage of AC1611 cleaved by the control substrate, where the initial substrate concentration was 6 µM, the reaction was incubated at 37°C for 2 hours, and then stopped by the addition of EDTA, wherein the non-reducing SDS- The amount of digested product and unlysed substrate was analyzed by PAGE to establish a ratio of percent cleavage. The cleavage efficiency was calculated as follows:

. Thus, a cleavage efficiency of -1 means that the amount of the test cleaved substrate is 50% compared to the amount of the control substrate, and a lysis efficiency of +1 means that the amount of the test cleaved substrate is 50% higher than the amount of the control substrate. The amount is 200%. A higher cleavage rate by the test protease relative to the control will result in a higher cleavage efficiency, and a slower cleavage rate by the test protease relative to the control will result in a lower cleavage efficiency. As detailed in the Examples, a control RS sequence AC1611 (RSR-1517) having the amino acid sequence EAGRSANHEPLGLVAT (SEQ ID NO: 7001) was established as having the cleavage rate of individual proteases in an in vitro biochemical assay. Protease cleavage efficiencies for appropriate baselines pod protein, MMP-2, MMP-7, MMP-9, MMP-14, uPA, and interstitial proteases. With selective amino acid substitutions at individual positions in the RS peptide, an RS library was created and evaluated against a panel of seven proteases (detailed more fully in the Examples), resulting in a set of phenotypes for the appropriate amino acid substitutions. guideline in order to arrive at a profile of RS with the desired cleavage efficiency. Substitution with the hydrophilic amino acids A, E, G, P, S, and T is preferred in producing an RS with the desired cleavage efficiency, however, other L-amino acids can be modified at a given position. Substitution to adjust cleavage efficiency as long as the RS retains at least some susceptibility to protease cleavage. Conservative amino acid substitutions in peptides to retain or achieve activity are well within the knowledge and ability of those skilled in the art. In one embodiment, the invention provides RS, wherein in an in vitro biochemical competition assay, the RS is cleaved at a high rate compared to the same protease cleavage with the control sequence RSR-1517 having the sequence EAGRSANHEPLGLVAT (SEQ ID NO. 7001) Cleavage efficiency of at least 0.2 log ₂ or 0.4 log ₂ or 0.8 log ₂ or 1.0 log ₂ is cleaved by proteases including but not limited to pod protein, MMP-1, MMP-2, MMP-7, MMP-9, MMP- 11. MMP-14, uPA or interstitial protease. In some embodiments, the invention provides RS, wherein in an in vitro biochemical competition assay, the RS is cleaved at a low Cleavage efficiency of at least 0.2 log ₂ or 0.4 log ₂ or 0.8 log ₂ or 1.0 log ₂ is cleaved by proteases including but not limited to pod protein, MMP-1, MMP-2, MMP-7, MMP-9, MMP- 11. MMP-14, uPA or interstitial protease. In one embodiment, the invention provides RS, wherein the rate of proteolytic cleavage of RS is at least 2 times faster, or at least 4 times faster, or at least 8 times faster than the control sequence RSR-1517 having the sequence EAGRSANHEPLGLVAT (SEQ ID NO. 7001) times, or at least 16 times, the proteases include but are not limited to podin, MMP-1, MMP-2, MMP-7, MMP-9, MMP-11, MMP-14, uPA or interstitial proteases. In some embodiments, the invention provides RS, wherein the protease cleavage rate of RS is at least 2 times slower, or at least 4 times slower, or at least 8 times slower than the control sequence RSR-1517 having the sequence EAGRSANHEPLGLVAT (SEQ ID NO. 7001) times, or at least 16 times, the proteases include but are not limited to podin, MMP-1, MMP-2, MMP-7, MMP-9, MMP-11, MMP-14, uPA or interstitial proteases.

In some embodiments, the invention provides AACs comprising multiple RSs, wherein each RS sequence is identified herein by the group of sequences set forth in Table 8a and the RS is identified by 1 to 6 as glycine, serine The amino acids of alanine, alanine, and threonine are linked to each other. In one embodiment, the AAC comprises a first RS and a second RS different from the first RS, wherein each RS sequence is identified herein by the sequence set forth in Table 8a and the RS is represented by 1 to 6 as Gan The amino acids of amino acid, serine, alanine and threonine are linked to each other. In some embodiments, the AAC comprises a first RS, a second RS different from the first RS, and a third RS different from the first RS and the second RS, wherein each sequence is set forth herein by Table 8a The sequences are identified and the first RS and the second RS and the third RS are connected to each other by 1 to 6 amino acids as glycine, serine, alanine and threonine. It is specifically contemplated that multiple RSs of an AAC can be joined to form a sequence that can be cleaved by various proteases at different rates or efficiencies. In some embodiments, the invention provides an AAC comprising RS1 and RS2 identified herein by the sequences set forth in Tables 8a-8b and XTEN 1 and XTEN 1 such as described above or elsewhere herein. XTEN 1 and XTEN 2 of XTEN 2, wherein RS1 is fused between XTEN1 and the binding moiety and RS2 is fused between XTEN2 and the binding moiety. It is contemplated that such compositions will be more readily cleaved by diseased target tissue expressing multiple proteases than healthy tissue or when in normal circulation, and thus the resulting fragments carrying the binding moiety will more readily penetrate target tissue such as a tumor, And have an enhanced ability to bind and link target cells and effector cells (or only target cells in the case of AACs designed with a single binding moiety).

The RS of the invention are suitable for inclusion in recombinant polypeptides as therapeutic agents for the treatment of cancer, autoimmune diseases, inflammatory diseases and other conditions requiring localized activation of recombinant polypeptides. Compositions of the invention address an unmet need and are superior to conventional antibody therapeutics or bispecific antibody therapeutics that are active after injection in one or more aspects, including enhanced terminal half-life, targeted delivery and improved therapeutic ratio and reduced toxicity to healthy tissues.

In some embodiments, the (fusion) polypeptide comprises a first release segment (RS1 ) located between the (first) XTEN and the biologically active polypeptide. In some embodiments, the polypeptide further comprises a second release segment (RS2) located between the biologically active polypeptide and the second XTEN. In some embodiments, the sequences of RS1 and RS2 are identical. In some embodiments, the sequences of RS1 and RS2 are not identical. In some embodiments, RS1 comprises at least 90%, 91%, 92%, 93%, 94%, 95%, 96% of a sequence identified herein by a sequence in Tables 8a-8b or a subset thereof Amino acid sequences with %, 97%, 98%, 99% or 100% sequence identity. In some embodiments, RS2 comprises at least 90%, 91%, 92%, 93%, 94%, 95%, 96% of a sequence identified herein by a sequence in Tables 8a-8b or a subset thereof Amino acid sequences with %, 97%, 98%, 99% or 100% sequence identity. In some embodiments, RS1 and RS2 are each substrates for cleavage by proteases at one, two or three cleavage sites within each release segment sequence.

reference fragment

In some embodiments, the (fusion) polypeptide further comprises one or more reference fragments that are releasable from the polypeptide following protease digestion. In some embodiments, the one or more reference fragments each comprise a portion of a biologically active polypeptide. In some embodiments, the one or more reference fragments are a single reference fragment that differs in sequence and molecular weight from all other peptide fragments that may be released from the polypeptide following protease digestion of the polypeptide.

Exemplary Polypeptides

In some embodiments of the compositions of the invention, the polypeptide is an amine comprising at least (about) 80% sequence identity to the sequence set forth in Table D (consisting of SEQ ID NOs: 12-47 ), or a subset thereof amino acid sequences of recombinant polypeptides. The polypeptide may comprise at least (about) 81%, at least (about) 82%, at least (about) 83%, at least (about) 84%, at least (about) 85%, at least (about) 86%, at least (about) 87%, at least (about) 88%, at least (about) 89%, at least (about) 90%, at least (about) 91 %, at least (about) 92%, at least (about) 93%, at least (about) 94%, at least (about) 95%, at least (about) 96%, at least (about) 97%, at least (about) 98% , an amino acid sequence having at least (about) 99% or (about) 100% sequence identity. The polypeptide may comprise at least (about) 90%, at least (about) 91%, at least (about) 92%, at least (about) 93%, at least (about) 94%, at least (about) 95%, at least (about) 96%, at least (about) 97%, at least (about) 98%, at least (about) 99% or (about) 100% Amino acid sequence of sequence identity. A polypeptide may comprise an amino acid sequence identical to the sequences set forth in Table D ( SEQ ID NOs: 12-47 ) or a subset thereof. With particular consideration, compositions of the invention may comprise sequence variants of the amino acid sequences set forth in Table D , such as having a linker sequence(s) inserted or having a purification tag sequence(s) attached thereto, It is sufficient that the variants exhibit one or more substantially similar or identical biological activities and/or activation mechanisms. Table D: Exemplary Amino Acid Sequences of Polypeptides SEQ ID NO. amino acid sequence 12 ASSPAGSPTSTESGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSTPAESGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGGSAPLGGRADNHEPPELGAGATSGSETPGTDIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQHYTTPPTFGQGTKVEIKGATPPETGAETESPGETTGGSAESEPPGEGEVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVRQAPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQGTLVTVSSGGGSELVVTQEPSLTVSPGGTVTLTCRSSTGAVTTSNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSSLGGSAALTLSGVQPEDEAEYYCALWYSNLWVFGGGTKLTVLGATPPETGAETESPGETTGGSAESEPPGEGEVQLQESGGGLVQPGGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYVSWFAYWGQGTLVTVSSGTAEAASASGLGGRADNHEPPELGAGSAGSPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSE SATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSTETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTATESPEGSAPGTSESATPESGPGTSTEPSEGSAPGTSAESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEP SEGSAPGTSESATPESGPGTESAS 13 ASSPAGSPTSTESGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSTPAESGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGEEPATSGSTPEGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGGSAPASTRGENAGPAGLEAPATSGSETPGTDIQMTQSPSSLSASVGDRVTITCKASQDVSIGVAWYQQKPGKAPKLLIYSASYRYTGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYYIYPYTFGQGTKVEIKGATPPETGAETESPGETTGGSAESEPPGEGEVQLVESGGGLVQPGGSLRLSCAASGFTFTDYTMDWVRQAPGKGLEWVADVNPNSGGSIYNQRFKGRFTLSVDRSKNTLYLQMNSLRAEDTAVYYCARNLGPSFYFDYWGQGTLVTVSSGGGSELVVTQEPSLTVSPGGTVTLTCRSSNGAVTSSNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSLLGGKAALTLSGVQPEDEAVYYCALWYPNLWVFGGGTKLTVLGATPPETGAETESPGETTGGSAESEPPGEGEVQLLESGGGIVQPGGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTVYLQMNNLKTEDTAVYYCVRHENFGNSYVSWFAHWGQGTLVTVSSGTAEAASASGASTRGENAGPAGLEAPPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTS TEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTESTPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGEPEA 14 ASSPAGSPTSTESGTSESATPESGPGTETEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSTPAESGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGESPATSGSTPEGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGGSAPEAGRSANHTPAGLTGPATSGSETPGTEIVLTQSPATLSLSPGERATLSCKASQDVSIGVAWYQQKPGQAPRLLIYSASYRYSGVPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQYYIYPYTFGQGTKVEIKGATPPETGAETESPGETTGGSAESEPPGEGQVQLVQSGVEVKKPGASVKVSCKASGFTFTDYTMDWVRQAPGQGLEWMADVNPNSGGSIYNQRFKGRVTLTTDSSTTTAYMELKSLQFDDTAVYYCARNLGPSFYFDYWGQGTLVTVSSGGGSELVVTQEPSLTVSPGGTVTLTCRSSNGAVTSSNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSSLGGKAALTLSGVQPEDEAVYYCALWYPNLWVFGGGTKLTVLGATPPETGAETESPGETTGGSAESEPPGEGEVQLQESGGGIVQPGGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTVYLQMNNLKTEDTAVYYCVRHENFGNSYVSWFAHWGQGTLVTVSSGTAEAASASGEAGRSANHTPAGLTGPTPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTST EPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSESATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESA 15 SPAGSPTSTESGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSTPAESGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGGSAPLFGRNDNHEPLELGGGATSGSETPGTDIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQHYTTPPTFGQGTKVEIKGATPPETGAETESPGETTGGSAESEPPGEGEVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVRQAPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQGTLVTVSSGGGSELVVTQEPSLTVSPGGTVTLTCRSSTGAVTTSNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSSLGGSAALTLSGVQPEDEAEYYCALWYSNLWVFGGGTKLTVLGATPPETGAETESPGETTGGSAESEPPGEGEVQLQESGGGLVQPGGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYVSWFAYWGQGTLVTVSSGTAEAASASGLFGRNDNHEPLELGGGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTST EEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTESTPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPG 16 ASSPAGSPTSTESGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSTPAESGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGGSAPRTGRTGESANETPAGLGGPATSGSETPGTEIVLTQSPATLSLSPGERATLSCKASQDVSIGVAWYQQKPGQAPRLLIYSASYRYSGVPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQYYIYPYTFGQGTKVEIKGATPPETGAETESPGETTGGSAESEPPGEGQVQLVQSGVEVKKPGASVKVSCKASGFTFTDYTMDWVRQAPGQGLEWMADVNPNSGGSIYNQRFKGRVTLTTDSSTTTAYMELKSLQFDDTAVYYCARNLGPSFYFDYWGQGTLVTVSSGGGSELVVTQEPSLTVSPGGTVTLTCRSSNGAVTSSNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSLLGGKAALTLSGVQPEDEAVYYCALWYPNLWVFGGGTKLTVLGATPPETGAETESPGETTGGSAESEPPGEGEVQLLESGGGIVQPGGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTVYLQMNNLKTEDTAVYYCVRHENFGNSYVSWFAHWGQGTLVTVSSGTAEAASASGRTGRTGESANETPAGLGGPGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESG PGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSTETGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATS 17 ASSPAGSPTSTESGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSTPAESGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGGSAPGAGRTDNHEPLELGAAATSGSETPGTDIQMTQSPSSLSASVGDRVTITCKASQDVSIGVAWYQQKPGKAPKLLIYSASYRYTGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYYIYPYTFGQGTKVEIKGATPPETGAETESPGETTGGSAESEPPGEGEVQLVESGGGLVQPGGSLRLSCAASGFTFTDYTMDWVRQAPGKGLEWVADVNPNSGGSIYNQRFKGRFTLSVDRSKNTLYLQMNSLRAEDTAVYYCARNLGPSFYFDYWGQGTLVTVSSGGGSELVVTQEPSLTVSPGGTVTLTCRSSTGAVTTSNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCALWYSNLWVFGGGTKLTVLGATPPETGAETESPGETTGGSAESEPPGEGEVQLLESGGGLVQPGGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYVSWFAYWGQGTLVTVSSGTAEAASASGGAGRTDNHEPLELGAATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTST EPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSESATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESA 18 GSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSESATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPESGRAANTGPPTLTAPATSGSETPGTDIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQHYTTPPTFGQGTKVEIKGAT PPETGAETESPGETTGGSAESEPPGEGEVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVRQAPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQGTLVTVSSGGGSELVVTQEPSLTVSPGGTVTLTCRSSNGAVTSSNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSSLGGKAALTLSGVQPEDEAVYYCALWYPNLWVFGGGTKLTVLGATPPETGAETESPGETTGGSAESEPPGEGEVQLQESGGGIVQPGGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTVYLQMNNLKTEDTAVYYCVRHENFGNSYVSWFAHWGQGTLVTVSSGTAEAASASGESGRAANTGPPTLTAPPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESA TPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTESTPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPG 19 ASSPAGSPTSTESGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSTPAESGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGGSAPASGRSTNAGPPGLTGPATSGSETPGTDIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQHYTTPPTFGQGTKVEIKGATPPETGAETESPGETTGGSAESEPPGEGEVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVRQAPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQGTLVTVSSGGGSELVVTQEPSLTVSPGGTVTLTCRSSTGAVTTSNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCALWYSNLWVFGGGTKLTVLGATPPETGAETESPGETTGGSAESEPPGEGEVQLLESGGGLVQPGGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYVSWFAYWGQGTLVTVSSGTAEAASASGASGRSTNAGPPGLTGPPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPT STEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTESTPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPG 20 SAGSPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSTPAESGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSTETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPES GPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTESASLFGRNDNHEPLELGGGATSGSETPGTEIVLTQSPATLSLSPGERATLSCKASQDVSIGVAWYQQKPGQAPRLLIYSASYRYSGVPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQYYIYPYTFGQGTKVEIKGATPPETGAETESPGETTGGSAESEPPGEGQVQLVQSGVEVKKPGASVKVSCKASGFTFTDYTMDWVRQAPGQGLEWMADVNPNSGGSIYNQRFKGRVTLTTDSSTTTAYMELKSLQFDDTAVYYCARNLGPSFYFDYWGQGTLVTVSSGGGSELVVTQEPSLTVSPGGTVTLTCRSSNGAVTSSNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSLLGGKAALTLSGVQPEDEAVYYCALWYPNLWVFGGGTKLTVLGATPPETGAETESPGETTGGSAESEPPGEGEVQLLESGGGIVQPGGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTVYLQMNNLKTEDTAVYYCVRHENFGNSYVSWFAHWGQGTLVTVSSGTAEAASASGLFGRNDNHEPLELGGGEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSE PATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESASPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESAT twenty one GSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPATSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESASPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPTTGRAGEAEGATSAGATGPATSGSETPGTDIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQHYTTPPTFGQGTKVEIK GATPPETGAETESPGETTGGSAESEPPGEGEVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVRQAPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQGTLVTVSSGGGSELVVTQEPSLTVSPGGTVTLTCRSSTGAVTTSNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCALWYSNLWVFGGGTKLTVLGATPPETGAETESPGETTGGSAESEPPGEGEVQLLESGGGLVQPGGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYVSWFAYWGQGTLVTVSSGTAEAASASGTTGRAGEAEGATSAGATGPGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSTETGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPT STEEGTSESATPESGPGSEPATS twenty two ASSPAGSPTSTESGTSESATPESGPGTETEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSTPAESGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGESPATSGSTPEGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGGSAPASGRGTNAGPAGLTGPATSGSETPGTDIQMTQSPSSLSASVGDRVTITCKASQDVSIGVAWYQQKPGKAPKLLIYSASYRYTGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYYIYPYTFGQGTKVEIKGATPPETGAETESPGETTGGSAESEPPGEGEVQLVESGGGLVQPGGSLRLSCAASGFTFTDYTMDWVRQAPGKGLEWVADVNPNSGGSIYNQRFKGRFTLSVDRSKNTLYLQMNSLRAEDTAVYYCARNLGPSFYFDYWGQGTLVTVSSGGGSELVVTQEPSLTVSPGGTVTLTCRSSNGAVTSSNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSSLGGKAALTLSGVQPEDEAVYYCALWYPNLWVFGGGTKLTVLGATPPETGAETESPGETTGGSAESEPPGEGEVQLQESGGGIVQPGGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTVYLQMNNLKTEDTAVYYCVRHENFGNSYVSWFAHWGQGTLVTVSSGTAEAASASGASGRGTNAGPAGLTGPPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPE SGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTESTPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPG twenty three ASSPAGSPTSTESGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSTPAESGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGEEPATSGSTPEGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGGSAPGAGRTDNHEPLELGAAATSGSETPGTDIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQHYTTPPTFGQGTKVEIKGATPPETGAETESPGETTGGSAESEPPGEGEVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVRQAPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQGTLVTVSSGGGSELVVTQEPSLTVSPGGTVTLTCRSSTGAVTTSNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSSLGGSAALTLSGVQPEDEAEYYCALWYSNLWVFGGGTKLTVLGATPPETGAETESPGETTGGSAESEPPGEGEVQLQESGGGLVQPGGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYVSWFAYWGQGTLVTVSSGTAEAASASGGAGRTDNHEPLELGAAPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATP ESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGftabTSESATPESGPGSEPATSGPTESGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTESTPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGEPEA twenty four SAGSPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSTPAESGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSTETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPES GPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTESASASGRAANETPPGLTGAATSGSETPGTEIVLTQSPATLSLSPGERATLSCKASQDVSIGVAWYQQKPGQAPRLLIYSASYRYSGVPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQYYIYPYTFGQGTKVEIKGATPPETGAETESPGETTGGSAESEPPGEGQVQLVQSGVEVKKPGASVKVSCKASGFTFTDYTMDWVRQAPGQGLEWMADVNPNSGGSIYNQRFKGRVTLTTDSSTTTAYMELKSLQFDDTAVYYCARNLGPSFYFDYWGQGTLVTVSSGGGSELVVTQEPSLTVSPGGTVTLTCRSSNGAVTSSNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSLLGGKAALTLSGVQPEDEAVYYCALWYPNLWVFGGGTKLTVLGATPPETGAETESPGETTGGSAESEPPGEGEVQLLESGGGIVQPGGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTVYLQMNNLKTEDTAVYYCVRHENFGNSYVSWFAHWGQGTLVTVSSGTAEAASASGASGRAANETPPGLTGAGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTS TEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSTETGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATS 25 GSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPATSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESASPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPASGRSTNAGPPGLTGPATSGSETPGTEIVLTQSPATLSLSPGERATLSCKASQDVSIGVAWYQQKPGQAPRLLIYSASYRYSGVPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQYYIYPYTFGQGTKVEIKGAT PPETGAETESPGETTGGSAESEPPGEGQVQLVQSGVEVKKPGASVKVSCKASGFTFTDYTMDWVRQAPGQGLEWMADVNPNSGGSIYNQRFKGRVTLTTDSSTTTAYMELKSLQFDDTAVYYCARNLGPSFYFDYWGQGTLVTVSSGGGSELVVTQEPSLTVSPGGTVTLTCRSSNGAVTSSNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSSLGGKAALTLSGVQPEDEAVYYCALWYPNLWVFGGGTKLTVLGATPPETGAETESPGETTGGSAESEPPGEGEVQLQESGGGIVQPGGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTVYLQMNNLKTEDTAVYYCVRHENFGNSYVSWFAHWGQGTLVTVSSGTAEAASASGASGRSTNAGPPGLTGPGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSTETGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTS ESATPESGPGSEPATS 26 ASSPAGSPTSTESGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSTPAESGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGEEPATSGSTPEGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGGSAPRTGRTGESANETPAGLGGPATSGSETPGTEIVLTQSPATLSLSPGERATLSCKASQDVSIGVAWYQQKPGQAPRLLIYSASYRYSGVPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQYYIYPYTFGQGTKVEIKGATPPETGAETESPGETTGGSAESEPPGEGQVQLVQSGVEVKKPGASVKVSCKASGFTFTDYTMDWVRQAPGQGLEWMADVNPNSGGSIYNQRFKGRVTLTTDSSTTTAYMELKSLQFDDTAVYYCARNLGPSFYFDYWGQGTLVTVSSGGGSELVVTQEPSLTVSPGGTVTLTCRSSTGAVTTSNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSSLGGSAALTLSGVQPEDEAEYYCALWYSNLWVFGGGTKLTVLGATPPETGAETESPGETTGGSAESEPPGEGEVQLQESGGGLVQPGGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYVSWFAYWGQGTLVTVSSGTAEAASASGRTGRTGESANETPAGLGGPPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSP AGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTESTPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPG 27 ASSPAGSPTSTESGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSTPAESGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGGSAPLFGRNDNHEPLELGGGATSGSETPGTDIQMTQSPSSLSASVGDRVTITCKASQDVSIGVAWYQQKPGKAPKLLIYSASYRYTGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYYIYPYTFGQGTKVEIKGATPPETGAETESPGETTGGSAESEPPGEGEVQLVESGGGLVQPGGSLRLSCAASGFTFTDYTMDWVRQAPGKGLEWVADVNPNSGGSIYNQRFKGRFTLSVDRSKNTLYLQMNSLRAEDTAVYYCARNLGPSFYFDYWGQGTLVTVSSGGGSELVVTQEPSLTVSPGGTVTLTCRSSTGAVTTSNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCALWYSNLWVFGGGTKLTVLGATPPETGAETESPGETTGGSAESEPPGEGEVQLLESGGGLVQPGGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYVSWFAYWGQGTLVTVSSGTAEAASASGLFGRNDNHEPLELGGGPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPE SGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGftabTSESATPESGPGSEPATSGPTESGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTESTPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGEPEA 28 ASSPAGSPTSTESGTSESATPESGPGTETEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSTPAESGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGESPATSGSTPEGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGGSAPTTGRAGEAANATSAGATGPATSGSETPGTDIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQHYTTPPTFGQGTKVEIKGATPPETGAETESPGETTGGSAESEPPGEGEVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVRQAPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQGTLVTVSSGGGSELVVTQEPSLTVSPGGTVTLTCRSSNGAVTSSNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSLLGGKAALTLSGVQPEDEAVYYCALWYPNLWVFGGGTKLTVLGATPPETGAETESPGETTGGSAESEPPGEGEVQLLESGGGIVQPGGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTVYLQMNNLKTEDTAVYYCVRHENFGNSYVSWFAHWGQGTLVTVSSGTAEAASASGTTGRAGEAANATSAGATGPSAGSPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTST EEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSTETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTATESPEGSAPGTSESATPESGPGTSTEPSEGSAPGTSAESATPESGPGSEPATSGSETPGTSTEPSEGSAP GTSTEPSEGSAPGTSESATPESGPGTESAS 29 SPAGSPTSTESGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSTPAESGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGGSAPTTGRATEAANATPAGLTGPATSGSETPGTDIQMTQSPSSLSASVGDRVTITCKASQDVSIGVAWYQQKPGKAPKLLIYSASYRYTGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYYIYPYTFGQGTKVEIKGATPPETGAETESPGETTGGSAESEPPGEGEVQLVESGGGLVQPGGSLRLSCAASGFTFTDYTMDWVRQAPGKGLEWVADVNPNSGGSIYNQRFKGRFTLSVDRSKNTLYLQMNSLRAEDTAVYYCARNLGPSFYFDYWGQGTLVTVSSGGGSELVVTQEPSLTVSPGGTVTLTCRSSTGAVTTSNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSSLGGSAALTLSGVQPEDEAEYYCALWYSNLWVFGGGTKLTVLGATPPETGAETESPGETTGGSAESEPPGEGEVQLQESGGGLVQPGGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYVSWFAYWGQGTLVTVSSGTAEAASASGTTGRATEAANATPAGLTGPTPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAP GTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSESATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESA 30 GSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSESATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPTTARAGSAENLSPSGLTGPATSGSETPGTDIQMTQSPSSLSASVGDRVTITCKASQDVSIGVAWYQQKPGKAPKLLIYSASYRYTGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYYIYPYTFGQGTKVEIK GATPPETGAETESPGETTGGSAESEPPGEGEVQLVESGGGLVQPGGSLRLSCAASGFTFTDYTMDWVRQAPGKGLEWVADVNPNSGGSIYNQRFKGRFTLSVDRSKNTLYLQMNSLRAEDTAVYYCARNLGPSFYFDYWGQGTLVTVSSGGGSELVVTQEPSLTVSPGGTVTLTCRSSNGAVTSSNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSSLGGKAALTLSGVQPEDEAVYYCALWYPNLWVFGGGTKLTVLGATPPETGAETESPGETTGGSAESEPPGEGEVQLQESGGGIVQPGGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTVYLQMNNLKTEDTAVYYCVRHENFGNSYVSWFAHWGQGTLVTVSSGTAEAASASGTTARAGSAENLSPSGLTGPEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESASPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEG SAPGTSESATPESGPGTSESAT 31 GSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSESATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPTTGRAGEAEGATSAGATGPATSGSETPGTDIQMTQSPSSLSASVGDRVTITCKASQDVSIGVAWYQQKPGKAPKLLIYSASYRYTGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYYIYPYTFGQGTKVEIK GATPPETGAETESPGETTGGSAESEPPGEGEVQLVESGGGLVQPGGSLRLSCAASGFTFTDYTMDWVRQAPGKGLEWVADVNPNSGGSIYNQRFKGRFTLSVDRSKNTLYLQMNSLRAEDTAVYYCARNLGPSFYFDYWGQGTLVTVSSGGGSELVVTQEPSLTVSPGGTVTLTCRSSTGAVTTSNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCALWYSNLWVFGGGTKLTVLGATPPETGAETESPGETTGGSAESEPPGEGEVQLLESGGGLVQPGGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYVSWFAYWGQGTLVTVSSGTAEAASASGTTGRAGEAEGATSAGATGPPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEG TSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTESTPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPG 32 ASSPAGSPTSTESGTSESATPESGPGTETEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSTPAESGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGESPATSGSTPEGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGGSAPPTGRSGEGANATPSGLTGPATSGSETPGTDIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQHYTTPPTFGQGTKVEIKGATPPETGAETESPGETTGGSAESEPPGEGEVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVRQAPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQGTLVTVSSGGGSELVVTQEPSLTVSPGGTVTLTCRSSTGAVTTSNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCALWYSNLWVFGGGTKLTVLGATPPETGAETESPGETTGGSAESEPPGEGEVQLLESGGGLVQPGGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYVSWFAYWGQGTLVTVSSGTAEAASASGPTGRSGEGANATPSGLTGPPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGT SESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGftabTSESATPESGPGSEPATSGPTESGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTESTPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGEPEA 33 ASSPAGSPTSTESGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSTPAESGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGGSAPLGGRADNHEPPELGAGATSGSETPGTDIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQHYTTPPTFGQGTKVEIKGATPPETGAETESPGETTGGSAESEPPGEGEVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVRQAPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQGTLVTVSSGGGSELVVTQEPSLTVSPGGTVTLTCRSSNGAVTSSNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSLLGGKAALTLSGVQPEDEAVYYCALWYPNLWVFGGGTKLTVLGATPPETGAETESPGETTGGSAESEPPGEGEVQLLESGGGIVQPGGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTVYLQMNNLKTEDTAVYYCVRHENFGNSYVSWFAHWGQGTLVTVSSGTAEAASASGLGGRADNHEPPELGAGTPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTS TEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSESATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESA 34 ASSPAGSPTSTESGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSTPAESGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGGSAPEAGRSANHTPAGLTGPATSGSETPGTDIQMTQSPSSLSASVGDRVTITCKASQDVSIGVAWYQQKPGKAPKLLIYSASYRYTGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYYIYPYTFGQGTKVEIKGATPPETGAETESPGETTGGSAESEPPGEGEVQLVESGGGLVQPGGSLRLSCAASGFTFTDYTMDWVRQAPGKGLEWVADVNPNSGGSIYNQRFKGRFTLSVDRSKNTLYLQMNSLRAEDTAVYYCARNLGPSFYFDYWGQGTLVTVSSGGGGSELVVTQEPSLTVSPGGTVTLTCRSSNGAVTSSNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSLLGGKAALTLSGVQPEDEAVYYCALWYPNLWVFGGGTKLTVLGATPPETGAETESPGETTGGSAESEPPGEGEVQLLESGGGIVQPGGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTVYLQMNNLKTEDTAVYYCVRHENFGNSYVSWFAHWGQGTLVTVSSGTAEAASASGEAGRSANHTPAGLTGPPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPT STEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTESTPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGEPEA 35 ASSPAGSPTSTESGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSTPAESGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGGSAPGAGRTDNHEPLELGAAATSGSETPGTEIVLTQSPATLSLSPGERATLSCKASQDVSIGVAWYQQKPGQAPRLLIYSASYRYSGVPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQYYIYPYTFGQGTKVEIKGATPPETGAETESPGETTGGSAESEPPGEGQVQLVQSGVEVKKPGASVKVSCKASGFTFTDYTMDWVRQAPGQGLEWMADVNPNSGGSIYNQRFKGRVTLTTDSSTTTAYMELKSLQFDDTAVYYCARNLGPSFYFDYWGQGTLVTVSSGGGSELVVTQEPSLTVSPGGTVTLTCRSSTGAVTTSNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSSLGGSAALTLSGVQPEDEAEYYCALWYSNLWVFGGGTKLTVLGATPPETGAETESPGETTGGSAESEPPGEGEVQLQESGGGLVQPGGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYVSWFAYWGQGTLVTVSSGTAEAASASGGAGRTDNHEPLELGAAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTS TEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTESTPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGEPEA 36 GSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPATSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESASPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPASGRAANETPPGLTGAATSGSETPGTEIVLTQSPATLSLSPGERATLSCKASQDVSIGVAWYQQKPGQAPRLLIYSASYRYSGVPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQYYIYPYTFGQGTKVEIKGAT PPETGAETESPGETTGGSAESEPPGEGQVQLVQSGVEVKKPGASVKVSCKASGFTFTDYTMDWVRQAPGQGLEWMADVNPNSGGSIYNQRFKGRVTLTTDSSTTTAYMELKSLQFDDTAVYYCARNLGPSFYFDYWGQGTLVTVSSGGGSELVVTQEPSLTVSPGGTVTLTCRSSNGAVTSSNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSSLGGKAALTLSGVQPEDEAVYYCALWYPNLWVFGGGTKLTVLGATPPETGAETESPGETTGGSAESEPPGEGEVQLQESGGGIVQPGGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTVYLQMNNLKTEDTAVYYCVRHENFGNSYVSWFAHWGQGTLVTVSSGTAEAASASGASGRAANETPPGLTGASAGSPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTS ESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSTETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTATESPEGSAPGTSESATPESGPGTSTEPSEGSAPGTSAESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTESAS 37 SAGSPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSTPAESGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSTETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPES GPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTESASESGRAANTGPPTLTAPATSGSETPGTDIQMTQSPSSLSASVGDRVTITCKASQDVSIGVAWYQQKPGKAPKLLIYSASYRYTGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYYIYPYTFGQGTKVEIKGATPPETGAETESPGETTGGSAESEPPGEGEVQLVESGGGLVQPGGSLRLSCAASGFTFTDYTMDWVRQAPGKGLEWVADVNPNSGGSIYNQRFKGRFTLSVDRSKNTLYLQMNSLRAEDTAVYYCARNLGPSFYFDYWGQGTLVTVSSGGGSELVVTQEPSLTVSPGGTVTLTCRSSNGAVTSSNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSSLGGKAALTLSGVQPEDEAVYYCALWYPNLWVFGGGTKLTVLGATPPETGAETESPGETTGGSAESEPPGEGEVQLQESGGGIVQPGGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTVYLQMNNLKTEDTAVYYCVRHENFGNSYVSWFAHWGQGTLVTVSSGTAEAASASGESGRAANTGPPTLTAPSAGSPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTS ESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSTETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTATESPEGSAPGTSESATPESGPGTSTEPSEGSAPGTSAESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTESAS 38 ASSPAGSPTSTESGTSESATPESGPGTETEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSTPAESGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGESPATSGSTPEGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGGSAPASGRGTNAGPAGLTGPATSGSETPGTEIVLTQSPATLSLSPGERATLSCKASQDVSIGVAWYQQKPGQAPRLLIYSASYRYSGVPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQYYIYPYTFGQGTKVEIKGATPPETGAETESPGETTGGSAESEPPGEGQVQLVQSGVEVKKPGASVKVSCKASGFTFTDYTMDWVRQAPGQGLEWMADVNPNSGGSIYNQRFKGRVTLTTDSSTTTAYMELKSLQFDDTAVYYCARNLGPSFYFDYWGQGTLVTVSSGGGSELVVTQEPSLTVSPGGTVTLTCRSSTGAVTTSNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCALWYSNLWVFGGGTKLTVLGATPPETGAETESPGETTGGSAESEPPGEGEVQLLESGGGLVQPGGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYVSWFAYWGQGTLVTVSSGTAEAASASGASGRGTNAGPAGLTGPEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSES ATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESASPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESAT 39 ASSPAGSPTSTESGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSTPAESGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGEEPATSGSTPEGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGGSAPEAGRSANHTPAGLTGPATSGSETPGTDIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQHYTTPPTFGQGTKVEIKGATPPETGAETESPGETTGGSAESEPPGEGEVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVRQAPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQGTLVTVSSGGGSELVVTQEPSLTVSPGGTVTLTCRSSNGAVTSSNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSLLGGKAALTLSGVQPEDEAVYYCALWYPNLWVFGGGTKLTVLGATPPETGAETESPGETTGGSAESEPPGEGEVQLLESGGGIVQPGGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTVYLQMNNLKTEDTAVYYCVRHENFGNSYVSWFAHWGQGTLVTVSSGTAEAASASGEAGRSANHTPAGLTGPSAGSPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSE SATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSTETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTATESPEGSAPGTSESATPESGPGTSTEPSEGSAPGTSAESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEP SEGSAPGTSESATPESGPGTESAS 40 ASSPAGSPTSTESGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSTPAESGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGGSAPASTRGENAGPAGLEAPATSGSETPGTDIQMTQSPSSLSASVGDRVTITCKASQDVSIGVAWYQQKPGKAPKLLIYSASYRYTGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYYIYPYTFGQGTKVEIKGATPPETGAETESPGETTGGSAESEPPGEGEVQLVESGGGLVQPGGSLRLSCAASGFTFTDYTMDWVRQAPGKGLEWVADVNPNSGGSIYNQRFKGRFTLSVDRSKNTLYLQMNSLRAEDTAVYYCARNLGPSFYFDYWGQGTLVTVSSGGGSELVVTQEPSLTVSPGGTVTLTCRSSTGAVTTSNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSSLGGSAALTLSGVQPEDEAEYYCALWYSNLWVFGGGTKLTVLGATPPETGAETESPGETTGGSAESEPPGEGEVQLQESGGGLVQPGGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYVSWFAYWGQGTLVTVSSGTAEAASASGASTRGENAGPAGLEAPPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPE SGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGftabTSESATPESGPGSEPATSGPTESGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTESTPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGEPEA 41 GSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSESATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPPTGRSGEGANATPSGLTGPATSGSETPGTEIVLTQSPATLSLSPGERATLSCKASQDVSIGVAWYQQKPGQAPRLLIYSASYRYSGVPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQYYIYPYTFGQGTKVEIK GATPPETGAETESPGETTGGSAESEPPGEGQVQLVQSGVEVKKPGASVKVSCKASGFTFTDYTMDWVRQAPGQGLEWMADVNPNSGGSIYNQRFKGRVTLTTDSSTTTAYMELKSLQFDDTAVYYCARNLGPSFYFDYWGQGTLVTVSSGGGSELVVTQEPSLTVSPGGTVTLTCRSSNGAVTSSNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSSLGGKAALTLSGVQPEDEAVYYCALWYPNLWVFGGGTKLTVLGATPPETGAETESPGETTGGSAESEPPGEGEVQLQESGGGIVQPGGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTVYLQMNNLKTEDTAVYYCVRHENFGNSYVSWFAHWGQGTLVTVSSGTAEAASASGPTGRSGEGANATPSGLTGPPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTESTPSEGSAPGSEPATSGSETPG TSESATPESGPGTSTEPSEGSAPG 42 SPAGSPTSTESGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSTPAESGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGGSAPRTGRTGESANETPAGLGGPATSGSETPGTDIQMTQSPSSLSASVGDRVTITCKASQDVSIGVAWYQQKPGKAPKLLIYSASYRYTGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYYIYPYTFGQGTKVEIKGATPPETGAETESPGETTGGSAESEPPGEGEVQLVESGGGLVQPGGSLRLSCAASGFTFTDYTMDWVRQAPGKGLEWVADVNPNSGGSIYNQRFKGRFTLSVDRSKNTLYLQMNSLRAEDTAVYYCARNLGPSFYFDYWGQGTLVTVSSGGGSELVVTQEPSLTVSPGGTVTLTCRSSNGAVTSSNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSLLGGKAALTLSGVQPEDEAVYYCALWYPNLWVFGGGTKLTVLGATPPETGAETESPGETTGGSAESEPPGEGEVQLLESGGGIVQPGGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTVYLQMNNLKTEDTAVYYCVRHENFGNSYVSWFAHWGQGTLVTVSSGTAEAASASGRTGRTGESANETPAGLGGPPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAG SPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTESTPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGEPEA 43 ASSPAGSPTSTESGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSTPAESGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGGSAPTTARAGSAENLSPSGLTGPATSGSETPGTDIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQHYTTPPTFGQGTKVEIKGATPPETGAETESPGETTGGSAESEPPGEGEVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVRQAPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQGTLVTVSSGGGSELVVTQEPSLTVSPGGTVTLTCRSSTGAVTTSNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCALWYSNLWVFGGGTKLTVLGATPPETGAETESPGETTGGSAESEPPGEGEVQLLESGGGLVQPGGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYVSWFAYWGQGTLVTVSSGTAEAASASGTTARAGSAENLSPSGLTGPPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGT SESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTESTPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPG 44 ASSPAGSPTSTESGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSTPAESGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGEEPATSGSTPEGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGGSAPLGGRADNHEPPELGAGATSGSETPGTDIQMTQSPSSLSASVGDRVTITCKASQDVSIGVAWYQQKPGKAPKLLIYSASYRYTGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYYIYPYTFGQGTKVEIKGATPPETGAETESPGETTGGSAESEPPGEGEVQLVESGGGLVQPGGSLRLSCAASGFTFTDYTMDWVRQAPGKGLEWVADVNPNSGGSIYNQRFKGRFTLSVDRSKNTLYLQMNSLRAEDTAVYYCARNLGPSFYFDYWGQGTLVTVSSGGGSELVVTQEPSLTVSPGGTVTLTCRSSNGAVTSSNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSSLGGKAALTLSGVQPEDEAVYYCALWYPNLWVFGGGTKLTVLGATPPETGAETESPGETTGGSAESEPPGEGEVQLQESGGGIVQPGGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTVYLQMNNLKTEDTAVYYCVRHENFGNSYVSWFAHWGQGTLVTVSSGTAEAASASGLGGRADNHEPPELGAGTPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTST EPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSESATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESA 45 SPAGSPTSTESGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSTPAESGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGGSAPTTGRAGEAEGATSAGATGPATSGSETPGTDIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQHYTTPPTFGQGTKVEIKGATPPETGAETESPGETTGGSAESEPPGEGEVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVRQAPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQGTLVTVSSGGGSELVVTQEPSLTVSPGGTVTLTCRSSTGAVTTSNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSSLGGSAALTLSGVQPEDEAEYYCALWYSNLWVFGGGTKLTVLGATPPETGAETESPGETTGGSAESEPPGEGEVQLQESGGGLVQPGGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYVSWFAYWGQGTLVTVSSGTAEAASASGTTGRAGEAEGATSAGATGPEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEE GTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESASPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESAT 46 SAGSPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSTPAESGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSTETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPES GPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTESASTTGRAGEAANATSAGATGPATSGSETPGTDIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQHYTTPPTFGQGTKVEIKGATPPETGAETESPGETTGGSAESEPPGEGEVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVRQAPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQGTLVTVSSGGGSELVVTQEPSLTVSPGGTVTLTCRSSTGAVTTSNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCALWYSNLWVFGGGTKLTVLGATPPETGAETESPGETTGGSAESEPPGEGEVQLLESGGGLVQPGGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYVSWFAYWGQGTLVTVSSGTAEAASASGTTGRAGEAANATSAGATGPPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAP GTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGftabTSESATPESGPGSEPATSGPTESGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTESTPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGEPEA 47 ASSPAGSPTSTESGTSESATPESGPGTETEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSTPAESGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGESPATSGSTPEGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGGSAPTTGRATEAANATPAGLTGPATSGSETPGTEIVLTQSPATLSLSPGERATLSCKASQDVSIGVAWYQQKPGQAPRLLIYSASYRYSGVPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQYYIYPYTFGQGTKVEIKGATPPETGAETESPGETTGGSAESEPPGEGQVQLVQSGVEVKKPGASVKVSCKASGFTFTDYTMDWVRQAPGQGLEWMADVNPNSGGSIYNQRFKGRVTLTTDSSTTTAYMELKSLQFDDTAVYYCARNLGPSFYFDYWGQGTLVTVSSGGGSELVVTQEPSLTVSPGGTVTLTCRSSNGAVTSSNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSLLGGKAALTLSGVQPEDEAVYYCALWYPNLWVFGGGTKLTVLGATPPETGAETESPGETTGGSAESEPPGEGEVQLLESGGGIVQPGGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTVYLQMNNLKTEDTAVYYCVRHENFGNSYVSWFAHWGQGTLVTVSSGTAEAASASGTTGRATEAANATPAGLTGPPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSP AGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTESTPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGEPEA Peptide mixture

The disclosure herein includes a mixture comprising a plurality of polypeptides of different lengths; the mixture comprising a first set of polypeptides and a second set of polypeptides. In some embodiments, each polypeptide in the first set of polypeptides comprises a barcode segment that (a) is releasable from the polypeptide by digestion with a protease, and (b) has a different allotropy than that releasable from the first set of polypeptides. Sequence and molecular weight of other fragments. In some embodiments, the second set of polypeptides does not have the barcode segment of the first set of polypeptides (eg, due to truncation). In some embodiments, both the first set of polypeptides and the second set of polypeptides each comprise a reference fragment that is (a) common to the first set of polypeptides and the second set of polypeptides and (b) digestible by digestion with a protease And release. In some embodiments, the ratio of the first set of polypeptides to polypeptides comprising the reference fragment is greater than 0.70. In some embodiments, the ratio of the first set of polypeptides to polypeptides comprising the reference fragment is greater than 0.80, 0.90, 0.95, or 0.98. In some embodiments, the reference fragment occurs no more than once in each polypeptide of the first set of polypeptides and the second set of polypeptides. In some embodiments, the protease is a protease that cleaves on the C-terminal side of glutamic acid residues. In some embodiments, the protease is Glu-C protease. In some embodiments, the protease is not trypsin. In some embodiments, polypeptides of varying lengths comprise polypeptides comprising at least one expanded recombinant polypeptide (XTEN), such as any XTEN described above or described anywhere else herein. In some embodiments, the first set of polypeptides comprises full-length polypeptides, wherein the barcode segment is a portion of the full-length polypeptides. In some embodiments, the full length polypeptide is a (fusion) polypeptide such as any (fusion) polypeptide described above or described anywhere else herein. In some embodiments, the barcode fragment does not have (does not include) both the N-terminal amino acid and the C-terminal amino acid of the full-length polypeptide. In some embodiments, mixtures of polypeptides of different lengths differ from each other by N-terminal truncations, C-terminal truncations, or both N-terminal and C-terminal truncations of the full-length polypeptide. In some embodiments, the first set of polypeptides may differ from the second set of polypeptides by one or more pharmacological properties. Non-limiting exemplary properties are included. Peptide Characterization Methods

The disclosure herein includes a method for assessing the relative amounts of a first set of polypeptides in a mixture to a second set of polypeptides in a mixture in a mixture comprising polypeptides of different lengths, wherein (1) each polypeptide of the first set of polypeptides co-occurs in the polypeptide one and only one barcode segment and (2) each polypeptide in the second set of polypeptides does not have a barcode segment common to polypeptides in the first set, wherein individual polypeptides in both the first polypeptide and the second set of polypeptides each Contains reference snippets. The method may comprise contacting the mixture with a protease to generate a plurality of proteolytic fragments resulting from cleavage of the first set of polypeptides and the second set of polypeptides, wherein the plurality of proteolytic fragments comprises a plurality of reference fragments and multiple barcode segments. The method may further comprise determining the ratio of the amount of barcode fragments to the amount of reference fragments, thereby estimating the relative amounts of the first set of polypeptides and the second set of polypeptides. In some embodiments, the barcode segment occurs no more than once in each polypeptide in the first set of polypeptides. In some embodiments, the reference fragment occurs no more than once in each polypeptide of the first set of polypeptides and the second set of polypeptides. In some embodiments, the plurality of proteolytic fragments comprises a plurality of reference fragments and a plurality of barcode fragments. In some embodiments, the protease cleaves the first set of polypeptides and the second set of polypeptides (or polypeptides of different lengths) on the C-terminal side of a glutamic acid residue not followed by a proline residue. In some embodiments, the protease is Glu-C protease. In some embodiments, the protease is not trypsin. In some embodiments, the step of determining the ratio of the amount of barcode fragments to the amount of reference fragments comprises identifying barcode fragments and reference fragments from the mixture after the mixture has been contacted with a protease. In some embodiments, barcode fragments and reference fragments are identified based on their respective qualities. In some embodiments, barcode fragments and reference fragments are identified via mass spectrometry. In some embodiments, barcode fragments and reference fragments are identified by liquid chromatography-mass spectrometry (LC-MS). In some embodiments, the step of determining the ratio of barcode fragments to reference fragments comprises isobaric labeling. In some embodiments, the step of determining the ratio of barcode fragments to reference fragments comprises spiking the mixture with one or both of isotopically labeled reference fragments and isotopically labeled barcode fragments. In some embodiments, polypeptides of varying lengths comprise polypeptides comprising at least one expanded recombinant polypeptide (XTEN) as described above or anywhere else herein. In some embodiments, the XTEN is characterized in that: (i) it comprises at least 100 or at least 150 amino acids; (ii) at least 90% of the amino acid residues of the XTEN are glycine (G), propylamine acid (A), serine (S), threonine (T), glutamic acid (E) or proline (P); and (iii) which comprise at least 4 different types of amino acids, the The amino acids are G, A, S, T, E or P. In some embodiments, the barcode segment, when present, is part of the XTEN. In some embodiments, the mixture of polypeptides of different lengths comprises a polypeptide that is any of the polypeptides described above or described anywhere else herein. In some embodiments, polypeptides of different lengths comprise full-length polypeptides and truncated fragments thereof. In some embodiments, the polypeptides of different lengths consist essentially of the full-length polypeptide and truncated fragments thereof. In some embodiments, mixtures of polypeptides of different lengths differ from each other by N-terminal truncations, C-terminal truncations, or both N-terminal and C-terminal truncations of the full-length polypeptide. In some embodiments, the full-length polypeptide is a polypeptide as described above or described anywhere else herein. In some embodiments, the ratio of the amount of barcode fragments to reference fragments is greater than 0.50, 0.60, 0.70, 0.80, 0.90, 0.95, 0.98, or 0.99. Peptide quantification based on isobaric labeling

In some embodiments, isobaric labels can be used to determine the ratio of barcode fragments to reference fragments. Those of ordinary skill will appreciate that isobaric labeling is a mass spectrometry strategy used in quantitative proteomics in which peptides or proteins (or portions thereof) are labeled with various chemical groups that are isobaric (same mass) However, it is different in terms of the distribution of heavy isotopes around its structure. These tags, often referred to as tandem mass tags, are designed such that the mass tag fragments at specific linker regions after high energy collision-induced dissociation (CID) during tandem mass spectrometry, thereby generating reporter ions of different masses. One of ordinary skill will understand that one of the most common isobaric tags is an amine-reactive tag.

The enhanced ability to detect and quantify truncated products (e.g., via isobaric labeling) can generate knowledge that can aid in the design of manufacturing processes including purification steps to eliminate unwanted variants in purified drug substances/products presence is minimized. recombinant production

The disclosure herein includes nucleic acids. The nucleic acid may comprise a polynucleotide (or polynucleotide sequence) encoding a (fusion) polypeptide such as any (fusion) polypeptide described above or described anywhere else herein; or the nucleic acid may comprise such a polynucleotide (or The reverse complement of the polynucleotide sequence).

The disclosure herein includes expression vectors comprising a polynucleotide sequence, such as any of the polynucleotide sequences described in the preceding paragraph, and regulatory sequences operably linked to the polynucleotide sequence.

The disclosure herein includes host cells comprising an expression vector such as any of the expression vectors described in the preceding paragraph. In some embodiments, the host cell is a prokaryotic cell. In some embodiments, the host cell is E. coli. In some embodiments, the host cell is a mammalian cell.

In some embodiments, the invention provides methods of making compositions of the invention. In one embodiment, the method comprises culturing a host cell comprising a nucleic acid construct encoding a polypeptide or an XTEN-containing composition of any of the embodiments described herein under conditions that promote expression of the polypeptide or BPXTEN fusion polypeptide, followed by using Standard purification methods (such as column chromatography, HPLC and the like) recover the polypeptide or BPXTEN fusion polypeptide, wherein the composition is recovered, wherein at least 70% of the binding fragment of the expressed polypeptide or BPXTEN fusion polypeptide, or at least 80%, or at least 90%, or at least 95%, or at least 97%, or at least 99% properly folded. In some embodiments of the method of manufacture, the expressed polypeptide or BPXTEN fusion polypeptide is recovered, wherein at least or at least 90%, or at least 95%, or at least 97%, or at least 99% of the polypeptide or BPXTEN fusion polypeptide is monomeric The soluble form was recovered.

In some embodiments, the present invention relates to methods of producing polypeptides and BPXTEN fusion polypeptides using E. coli or mammalian host cells at high fermentative expression of functional proteins and providing expression vectors encoding constructs suitable for use in In a method for producing a cytotoxic active polypeptide construct composition at high expression. In one embodiment, the method comprises the following steps: 1) preparing a polynucleotide encoding the polypeptide of any one of the embodiments disclosed herein; 2) cloning the polynucleotide into an expression vector, the expression The vector can be a plastid or other vector under the control of transcription and translation sequences suitable for high-level protein expression in biological systems; 3) use the expression vector to transform appropriate host cells; The host cells are cultured in conventional nutrient media under the desired conditions. When necessary, the host cell is Escherichia coli. Expressing the polypeptide by this method allows the expression product of the host cell to have at least 0.05 g/L, or at least 0.1 g/L, or at least 0.2 g/L, or at least 0.3 g/L, or at least 0.5 g/L, or at least 0.6 g/L, or at least 0.7 g/L, or at least 0.8 g/L, or at least 0.9 g/L, or at least 1 g/L, or at least 2 g/L, or at least 3 g/L, or at least 4 g /L, or a fermentability value of at least 5 g/L, and wherein at least 70%, or at least 80%, or at least 90%, or at least 95%, or at least 97%, or at least 99% of the expressed protein Properly folded. The term "properly folded" as used herein means that the antigen-binding fragment component of the composition is capable of specifically binding its target ligand. In some embodiments, the present invention provides a method of producing a polypeptide or BPXTEN fusion polypeptide comprising a fermentation reaction that effectively exhibits an optical density in excess of about 10 when the fermentation reaction reaches an optical density of at least 130 at a wavelength of 600 nm. Milligrams per gram dry weight of host cells (mg/g), or at least about 250 mg/g, or about 300 mg/g, or about 350 mg/g, or about 400 mg/g, or about 450 mg/g, or Cultivating a host cell under the condition of a polypeptide product at a polypeptide concentration of about 500 mg/g, the host cell comprising a vector encoding a polypeptide comprising the aforementioned polypeptide or a BPXTEN fusion polypeptide; and wherein the antigen-binding fragment of the expressed protein is properly folded . In some embodiments, the present invention provides a method of producing a polypeptide or BPXTEN fusion polypeptide comprising a fermentation reaction that effectively exhibits an optical density in excess of about 10 when the fermentation reaction reaches an optical density of at least 130 at a wavelength of 600 nm. Milligrams per gram dry weight of host cells (mg/g), or at least about 250 mg/g, or about 300 mg/g, or about 350 mg/g, or about 400 mg/g, or about 450 mg/g, or A host cell comprising a vector encoding the composition is cultured under conditions where the polypeptide product is present at a concentration of about 500 mg/g of the polypeptide; and wherein the expressed polypeptide product is soluble. pharmaceutical composition

The disclosure herein includes pharmaceutical compositions comprising a (fusion) polypeptide, such as any of the (fusion) polypeptides described above or described anywhere else herein, and one or more pharmaceutically acceptable excipients. peptide. In some embodiments, pharmaceutical compositions are formulated for intradermal, subcutaneous, oral, intravenous, intraarterial, intraperitoneal, intraperitoneal, intravitreal, intrathecal, or intramuscular administration. In some embodiments, pharmaceutical compositions are in liquid form or frozen. In some embodiments, the pharmaceutical composition is in a device that is implanted in the eye or another body part. In some embodiments, the pharmaceutical composition is in a prefilled syringe for single injection. In some embodiments, pharmaceutical compositions are formulated as lyophilized powders to be reconstituted prior to administration.

In some embodiments, the dosage is administered intradermally, subcutaneously, orally, intravenously, intravitreally (or otherwise injected into the eye), intraarterially, intraperitoneally, intraperitoneally, intrathecally, or intramuscularly. In some embodiments, pharmaceutical compositions are administered using devices implanted in the eye or other body part. In some embodiments, the individual is a mouse, rat, monkey or human.

Pharmaceutical compositions can be administered by any suitable route for therapy. In addition, the pharmaceutical composition may also contain other pharmaceutically active compounds or a plurality of compounds of the present invention.

In some embodiments, pharmaceutical compositions can be administered subcutaneously, orally, intramuscularly, or intravenously. In one embodiment, the pharmaceutical composition is administered in a therapeutically effective dosage. In some instances of the foregoing, the therapeutically effective dose results in an increase in time spent within the therapeutic window of the fusion protein compared to the corresponding BP with the fusion protein not linked to XTEN and administered to the individual at comparable doses. The increase in time spent within the therapeutic window may be at least three times greater than the corresponding BP not linked to XTEN, or alternatively at least four times, or five times, or six times, or seven times greater than the corresponding BP not linked to XTEN times, or eight times, or nine times, or at least 10 times, or at least 20 times.

In some embodiments, the present invention provides methods of treating a disease, disorder or condition comprising administering to a subject a pharmaceutical composition described above using multiple consecutive doses of the pharmaceutical composition, the doses being therapeutically effective Dosage regimen to administer. In one embodiment of the foregoing, the therapeutically effective dosage regimen may be at least two times the blood level of the fusion protein compared to the corresponding BP with the fusion protein not linked to the XTEN(s) and administered to the subject at a comparable dosage regimen. At least three-fold, or alternatively at least four-fold, or five-fold, or six-fold, or seven-fold, or eight-fold, or nine-fold, or at least 10-fold increase in time between successive C _peaks and/or C _mm troughs times or at least 20 times. In some embodiments of the foregoing, less frequent dosing or less frequent administration is used than the corresponding biologically active protein component(s) not linked to the XTEN(s) and administered to the individual using a therapeutically effective regimen for the individual. Fusion Proteins of Pharmaceutical Compositions at Low Total Molar Doses Administration of the fusion protein results in a considerable improvement in at least one measured parameter.

In one embodiment, the pharmaceutical composition is administered subcutaneously. In this embodiment, the composition may be supplied as a lyophilized powder to be reconstituted prior to administration. The compositions may also be supplied in liquid or frozen form for direct administration to the patient. In one embodiment, the composition is supplied in liquid form in a prefilled syringe so that the patient can easily self-administer the composition.

Extended release formulations suitable for use in the present invention may be oral formulations comprising a matrix and a coating composition. Suitable base materials may include waxes (such as camauba, beeswax, paraffin, ceresine, shellac wax, fatty acids and fatty alcohols), oils, hardened oils or fats (such as hardened rapeseed oil, castor oil, sesame oil, tallow, palm oil, and soybean oil) and polymers (such as hydroxypropylcellulose, polyvinylpyrrolidone, hydroxypropylmethylcellulose, and polyethylene glycol). Other suitable matrix tablet materials are microcrystalline cellulose, powdered cellulose, hydroxypropyl cellulose, ethyl cellulose and other carriers and fillers. Tablets may also contain granules, coated powders or aggregates. Tablets may also be multilayered. Multilayer lozenges are especially preferred when the active ingredients have significantly different pharmacokinetic profiles. The finished lozenges may be coated or uncoated, as appropriate.

Coating compositions may comprise insoluble matrix polymers and/or water soluble materials. Water soluble materials can be polymers such as polyethylene glycol, hydroxypropylcellulose, hydroxypropylmethylcellulose, polyvinylpyrrolidone, polyvinyl alcohol; or monomeric materials such as sugars (e.g., lactose, sucrose, , fructose, mannitol and similar sugars), salts ( such as sodium chloride, potassium chloride and similar salts), organic acids (such as fumaric acid, succinic acid, lactic acid and tartaric acid), and mixtures thereof . Enteric polymers may optionally be incorporated into the coating composition. Suitable enteric polymers include hydroxypropylmethylcellulose, acetate succinate, hydroxypropylmethylcellulose, phthalates, polyvinyl acetate phthalate, ortho Cellulose acetate phthalate, cellulose acetate trimellitate, shellac, zein, and polymethacrylates containing carboxyl groups. The coating composition can be plasticized by adding suitable plasticizers such as diethyl phthalate, citric acid esters, polyethylene glycol, glycerin, acetylated glycerides, ethyl Acyl citrate, dibutyl sebacate and castor oil. The coating composition may also include fillers, which may be insoluble materials such as silicon dioxide, titanium dioxide, talc, kaolin, aluminum oxide, starch, powdered cellulose, MCC or polacrilin potassium. The coating composition can be applied as a solution or latex in an organic or aqueous solvent or a mixture thereof. Solvents such as water, lower alcohols, lower chlorinated hydrocarbons, ketones or mixtures thereof can be used.

The BPXTEN polypeptide of the present invention can be formulated according to known methods for preparing pharmaceutically applicable compositions, so that the polypeptide can be mixed with a pharmaceutically acceptable carrier such as aqueous solution or buffer solution, pharmaceutically acceptable suspension and emulsion. Mixture of agents and media. Examples of non-aqueous solvents include propyl glycol, polyethylene glycol, and vegetable oils. Therapeutic formulations are prepared for storage as lyophilized formulations or as aqueous solutions by mixing the active ingredient with the desired degree of purity and optionally with physiologically acceptable carriers, excipients or stabilizers. , as described in Remington's Pharmaceutical Sciences 16th Ed., Osol, A. Ed. (1980). The compositions of the present invention can be formulated using a variety of excipients. Suitable excipients include microcrystalline cellulose (e.g. Avicel PH 102, Avicel PH101), polymethacrylates, poly(ethyl acrylate, methyl methacrylate, trimethylammonium ethyl methacrylate chloride) (such as Eudragit RS-30D), hydroxypropyl methylcellulose (Methocel K10OM, Premium CR Methocel K10OM, Methocel E5, Opadry®), magnesium stearate, talc, triethyl citrate, aqueous ethylcellulose dispersion solution (Surelease®) and protamine sulfate. Slow release formulations may also comprise a carrier which may include, for example, solvents, dispersion media, coatings, antibacterial and antifungal agents, isotonic and absorption delaying agents. Pharmaceutically acceptable salts can also be used in these slow release preparations, such pharmaceutically acceptable salts are: inorganic salts such as hydrochloride, hydrobromide, phosphate or sulfate; and organic Salts of acids such as acetates, propionates, malonates or benzoates. The compositions may also contain liquids such as water, saline, glycerol and ethanol, and substances such as wetting agents, emulsifying agents or pH buffering agents. Liposomes can also be used as carriers.

唑啉、聚乙基

唑啉、聚羥丙基

唑啉、聚羥丙基甲基丙烯醯胺、聚甲基丙烯醯胺、聚二甲基丙烯醯胺、聚羥丙基甲基丙烯酸酯、聚羥乙基丙烯酸酯、羥甲基纖維素羥乙基纖維素、聚乙二醇、聚天冬醯胺及親水性肽序列，如美國專利第6,316,024號；第6,126,966號；第6,056,973號；第6,043,094號中所描述，該等專利之內容以全文引用之方式併入。 In some embodiments, compositions of the invention are encapsulated in liposomes that exhibit utility in delivering beneficial active agents in a controlled manner over an extended period of time. Liposomes are closed bilayer membranes containing an trapped aqueous volume. Liposomes can also be unilamellar vesicles having a single membrane bilayer or multilamellar vesicles having multiple membrane bilayers, each membrane bilayer being separated from the next by an aqueous layer. The structure of the resulting membrane bilayer is such that the hydrophobic (non-polar) tails of the lipids are oriented towards the center of the bilayer, while the hydrophilic (polar) heads are oriented towards the aqueous phase. In one embodiment, liposomes can be coated with a flexible water-soluble polymer to avoid uptake by organs of the mononuclear phagocyte system, mainly the liver and spleen. Suitable hydrophilic polymers for enclosing liposomes include, but are not limited to, PEG, polyvinylpyrrolidone, polyvinylmethyl ether, polymethyl

oxazoline, polyethyl

Azoline, polyhydroxypropyl

Azoline, polyhydroxypropylmethacrylamide, polymethacrylamide, polydimethylacrylamide, polyhydroxypropylmethacrylate, polyhydroxyethylacrylate, hydroxymethylcellulose Ethylcellulose, polyethylene glycol, polyasparagine, and hydrophilic peptide sequences, as described in U.S. Patent Nos. 6,316,024; 6,126,966; 6,056,973; 6,043,094, the contents of which are reproduced in their entirety Incorporated by reference.

Liposomes can be composed of any lipid or combination of lipids known in the art. For example, the vesicle-forming lipids can be naturally occurring lipids or synthetic lipids, including lipids such as phosphatidylcholine, phosphatidylethanolamine, phosphatidic acid, phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, and sphingolipids. Phospholipids of phospholipids are disclosed in US Pat. Nos. 6,056,973 and 5,874,104. Vesicle-forming lipids may also be glycolipids, cerebrosides, or cationic lipids, such as 1,2-dioleyloxy-3-(trimethylamino)propane (DOTAP); N-[1-(2,3 ,-di(tetradecyl)oxy)propyl]-N,N-dimethyl-N-hydroxyethylammonium bromide (DMRIE); N-[1[(2,3,-dioleyloxy N-[1-(2,3-dioleyloxy)propyl]-N,N, N-trimethylammonium chloride (DOTMA); 3 [N-(N',N'-dimethylaminoethane)carbamoyl]cholesterol (DC-Choi); or dimethylbis(octadecyl base) ammonium (DDAB), as also disclosed in US Patent No. 6,056,973. Cholesterol can also be present in appropriate ranges to impart stability to vesicles, as disclosed in US Pat. Nos. 5,916,588 and 5,874,104.

Additional liposome technology is described in US Patent Nos. 6,759,057; 6,406,713; 6,352,716; 6,316,024; 6,294,191; 6,126,966; No. 5,215,680; and No. 4,684,479, the contents of which are incorporated herein by reference. These patents describe liposomes and lipid-encapsulated microvesicles and methods for their manufacture. Accordingly, it is contemplated by those skilled in the art that both the disclosure of the present invention and the disclosure of these other patents may result in liposomes for extended release of the polypeptides of the invention. For liquid formulations, the desired characteristic is that the formulation be supplied in a form that can be passed through a 25, 28, 30, 31, 32 gauge needle for intravenous, intramuscular, intraarticular or subcutaneous administration.

Administration via transdermal formulations can be performed using methods also known in the art, including methods generally described in, for example, U.S. Pat. The methods of No. 4,284,444 and WO 89/09051, which are incorporated herein by reference in their entirety. Transdermal patches are a particularly suitable example for polypeptides with absorption problems. Patches can be manufactured to control the release of the skin-penetrating active ingredient over a 12 hour, 24 hour, 3 day and 7 day period. In one example, a 2-fold excess per day of a polypeptide of the invention is placed in a non-volatile fluid. The compositions of the present invention are provided in the form of viscous, non-volatile liquids. The penetration rate of a particular formulation through the skin can be measured by methods standard in the art (eg, Franz et al., J. Invest. Derm. 64: 194-195 (1975)). Examples of suitable patches are passive transfer skin patches, iontophoresis skin patches or patches with microneedles such as Nicoderm. In other embodiments, the compositions may be delivered to the brain via intranasal, buccal, or sublingual routes to enable transfer of the active agent into the CNS via the olfactory channel and reduce systemic administration. Devices commonly used for this route of administration are included in US Patent No. 6,715,485. Compositions delivered via this route may enable increased CNS delivery or reduced overall systemic burden, thereby reducing the risk of systemic toxicity associated with certain drugs. Preparation of pharmaceutical compositions for delivery in subdermal implantable devices can be performed using methods known in the art, such as described in, for example, U.S. Patent Nos. 3,992,518; 5,660,848; and 5,756,115 The method in the number.

Osmotic pumps are available as slow release agents in the form of tablets, pills, capsules or implantable devices. Osmotic pumps are well known in the art and are readily available from companies of ordinary skill in the art who have their own experience in providing osmotic pumps for extended release drug delivery. Examples are DUROS™ from ALZA; OROS™ from ALZA; the Osmodex™ system from Osmotica Pharmaceutical; the EnSoTrol™ system from Shire Laboratories; and Alzet™. Patents describing osmotic pump technology are U.S. Patent Nos. 6,890,918; 6,838,093; 6,814,979; 6,713,086; 6,534,090; 6,110,498; 5,573,776; 4,200,0984; and 4,088,864, the contents of which are incorporated herein by reference. It will be appreciated by those skilled in the art that both the disclosure of the present invention and the disclosures of these other patents may result in osmotic pumps for the extended release of polypeptides of the invention.

A syringe pump can also be used as a slow release agent. These devices are described in U.S. Patent Nos. 4,976,696; 4,933,185; 5,017,378; 6,309,370; 6,254,573; 4,435,173; ; No. 5,318,540; and No. 4,988,337, the contents of which are incorporated herein by reference. It will be appreciated by those skilled in the art that both the disclosure of the present invention and the disclosures of these other patents may result in a syringe pump for extended release of the compositions of the present invention. medicine set

In some embodiments, the invention provides kits that facilitate the use of BPXTEN polypeptides. In one embodiment, the kit comprises, in at least a first container: (a) an amount of a BPXTEN fusion protein composition sufficient to treat a disease, condition or disorder upon administration to an individual in need thereof; and (b) A certain amount of pharmaceutically acceptable carrier; together constitute a formulation ready for injection or reconstituted with sterile water, buffer or dextrose; and a label identifying the BPXTEN drug and storage and handling conditions and the approved application of the drug Symptom table, BPXTEN drug reconstitution and/or administration instructions for prophylaxis and/or treatment of approved indications, appropriate dosage and safety information, and information identifying the batch and expiration date of the drug. In some embodiments of the foregoing, the kit can include a second container that can carry a diluent suitable for the BPXTEN composition, which second container will provide the user with the appropriate concentration of BPXTEN to be delivered to the individual. treatment method

The disclosure herein includes the use of a polypeptide, such as any polypeptide described above or anywhere else herein, for the manufacture of a medicament for treating a disease in a subject. In some embodiments, the particular disease to be treated will depend on the choice of bioactive protein. In some embodiments, the disease is cancer (including any form thereof). In some instances, a cancer or tumor can be characterized by low, intermediate or high expression of HER2.

The disclosure herein includes methods of treating a disease in a subject comprising administering to a subject in need thereof one or more therapeutically effective doses of a pharmaceutical composition, such as any of the pharmaceutical compositions described above or described anywhere else herein . In some embodiments, the disease is cancer (including any form thereof). In some embodiments, the individual is a mouse, a rat, a monkey, and a human. In some instances, a cancer or tumor can be characterized by low, intermediate or high expression of HER2.

In certain embodiments, the HER-2 targeting bispecific compositions of the invention (and in particular AMX818) may advantageously be combined with a second therapeutic agent effective in treating or ameliorating the effects of cancer. The additional therapeutic agent may be selected from the group consisting of antibodies, antibody fragments, antibody conjugates, cytotoxic agents, toxins, radionuclear species, immunomodulators, photosensitizing therapeutic agents, radiosensitizers, hormones, anti-angiogenic agents, and its combination. Particularly preferred second or additional therapeutic agents include other HER2 targeting agents, chemotherapeutics, radiotherapeutics, and agents targeting HER3 and other targets involved in resistance to HER2 driven cancer therapy.

Examples of therapeutic antibodies that may be used in the present invention include rituximab (Rituxan), Brentuximab Vedotin (Adcetriz), trastuzumab Ado-trastuzumab emtansine (Kadcyla), Cetuximab (Erbitux), bevacizumab (Avastin (Avastin), Ibritumomab (Zevalin), Vedolizumab (Entyvio), Ipilimumab (Evoy ( Yervoy), Nivolumab (Opdivo), Pembrolizumab (Keytruda), Alemtuzamab atezolizumab ( Tecentriq), avelumab (Bavencio), durvalumab (Imfinzi), B-701, avelumab (Ofatumumab), Atezolizumab (Obinutuzumab) (Gazyva) Panitumumab (Panitumumab), Prazalizumab (plozalizumab), BI-754091, OREG-103, COM-701, BI- 754111 and combinations thereof.

According to some embodiments, the antibody, fragment thereof, or conjugate thereof is selected from the group consisting of: rituximab (Rituximab), vedotin (Bentuximab), trastuzumab-Mituximab Tansin (Kadekla), Ipilimumab (Evoy), Nivolumab (Opdivo), Pembrolizumab (Korida), Alemtuzumab Atezolizumab (Taisheng Odd), durvalumab (Infineon), ofatumumab, atezolizumab (Gazeva), panitumumab, and combinations thereof.

In other embodiments, additional agents may be DNA damaging agents, antimetabolites, antimicrotubule agents, antibiotic agents, and the like. DNA damaging agents include alkylating agents, platinum-based agents, intercalators, and DNA replication inhibitors. Non-limiting examples of DNA alkylating agents include cyclophosphamide, dichloromethyldiethylamine, uramustine, melphalan, merulinate, ifosfamide , carmustine (carmustine), lomustine (lomustine), streptozotocin, butacaine sulfate (busulfan), temozolomide (temozolomide), their pharmaceutically acceptable salts, prodrugs and combination. Non-limiting examples of platinum-based agents include cisplatin, carboplatin, oxaliplatin, nedaplatin, satraplatin, triplatin tetranitrate, pharmaceutically acceptable Salts, prodrugs and combinations thereof. Non-limiting examples of intercalators include cranberries, daunorubicin, idarubicin, mitoxantrone, pharmaceutically acceptable salts thereof, prodrugs, and combinations thereof . Non-limiting examples of DNA replication inhibitors include irinotecan, topotecan, amsacrine, etoposide, etoposide phosphate, teniposide ), pharmaceutically acceptable salts, prodrugs and combinations thereof. Antimetabolites include: folate antagonists, such as methotrexate and premetrexed; purine antagonists, such as 6-mercaptopurine, dacarbazine, and fludarabine; and pyrimidines Antagonists such as 5-fluorouracil, cytarabine, capecitabine, gemcitabine, decitabine, pharmaceutically acceptable salts thereof, prodrugs, and combinations thereof. Anti-microtubule agents include, but are not limited to, vinca alkaloids, paclitaxel (Taxol®), docetaxel (Taxotere®), and ixabepilone (Ixempra®). Antibiotic agents include, but are not limited to, actinomycin, anthracycline, valrubicin, epirubicin, bleomycin, plicamycin, mitomycin Suspensions, pharmaceutically acceptable salts thereof, prodrugs and combinations thereof.

Exemplary cytotoxic agents are known to those skilled in the art and may, for example, be selected from the group consisting of: cyclophosphamide, dichloromethyldiethylamine, uramustine, melphalan, chlormustine Butyric acid, ifosfamide, carmustine, lomustine, streptozotocin, butacaine sulfate, temozolomide, cisplatin, carboplatin, oxaliplatin, nedaplatin, satite Platinum, triplatinum tetranitrate, cranberry, daunomycin, adamycin, mitoxantrone, methotrexate, pemetrexed, 6-mercaptopurine, dacarbazine, fludarabine, 5-fluorouracil, cytarabine, capecitabine, gemcitabine, decitabine, vinca alkaloids, paclitaxel (paclitaxel), docetaxel (Taxotere), ixabepilone ( Ixempra), actinomycin, anthracycline, valrubicin, epirubicin, bleomycin, plicamycin, mitomycin, its pharmaceutically acceptable salts, prodrugs and combinations thereof.

Cytotoxic agents of the present invention also include PI3K/Akt pathway inhibitors. Non-limiting examples of PI3K/Akt pathway inhibitors include A-674563 (CAS No. 552325-73-2), AGL 2263, AMG-319 (Amgen, Thousand Oaks, Calif.), AS-041164 (5-benzo[ 1,3]dioxol-5-ylmethylene-thiazolidin-2,4-dione), AS-604850 (5-(2,2-difluoro-benzo[1,3 ]Dioxol-5-ylmethylene)-thiazolidine-2,4-dione), AS-605240 (5-quinoxaline-6-methylene-1,3-thiazolidine -2,4-dione), AT7867 (CAS No. 857531-00-1); benzimidazole series, Genentech (Roche Holdings, South San Francisco, Calif.), BML-257 (CAS No. 32387-96-5 ), BVD-723, CAL-120 (Gilead Sciences, Foster City, Calif.), CAL-129 (Gilead Sciences), CAL-130 (Gilead Sciences), CAL-253 (Gilead Sciences), CAL-263 (Gilead Sciences ), CAS No. 612847-09-3, CAS No. 681281-88-9, CAS No. 75747-14-7, CAS No. 925681-41-0, CAS No. 98510-80-6, CCT128930 (CAS No. 885499-61- 6), CH5132799 (CAS No. 1007207-67-1), CHR-4432 (Chroma Therapeutics Limited, Abingdon, UK), FPA 124 (CAS No. 902779-59-3), GS-1101 (CAL-101) (Gilead Sciences), GSK 690693 (CAS No. 937174-76-0), H-89 (CAS No. 127243-85-0), Honokiol, IC87114 (Gilead Science), IPI-145 (Intellikine), KAR-4139 (Karus Therapeutics, Chilworth, UK), KAR-4141 (Karus Therapeutics), KIN-1 (Karus Therapeutics), KT 5720 (CAS No. 108068 -98-0), Miltefosine, MK-2206 Dihydrochloride (CAS No. 1032350-13-2), ML-9 (CAS No. 105637-50-1), Natrindole Hydrochloride Salt (Naltrindole Hydrochloride), OXY-111A (NormOxys Company, Brighton, Mass.), Perifosine (perifosine), PHT-427 (CAS number 1191951-57-1); PI3 kinase delta inhibitor, Merck KGaA (Merck & Co., Whitehouse Station, N.J.); PI3 Kinase Delta Inhibitor, Genentech (Roche Holdings); PI3 Kinase Delta Inhibitor, Incozen (Incozen Therapeutics, Pvt. Ltd., Hydrabad, India); PI3 Kinase Delta Inhibitor- 2, Incozen (Incozen Therapeutics); PI3 kinase inhibitor, Roche-4 (Roche Holdings company); PI3 kinase inhibitor, Roche (Roche Holdings company); PI3 kinase inhibitor, Roche-5 (Roche Holdings company); α/δ inhibitor, Pathway Therapeutics (Pathway Therapeutics Co., Ltd., South San Francisco, Calif.); PI3-δ inhibitor, Cellzome (Cellzome AG, Heidelberg, Germany); PI3-δ inhibitor, Intellikine (Intellikine Company, La Jolla, Calif.); PI3-δ Inhibitor, Pathway Therapeutics-1 (Pathway Therapeutics Inc.); PI3-δ Inhibitor, Pathway Therapeutics-2 (Pathway Therapeutics Inc.); PI3-δ/γ Inhibitor, Cellzome ( Cellzome AG); PI3-δ/γ Inhibitor, Cellzome (Cellzome AG); PI3-δ/γ Inhibitor, Intellikine (Intellikine); PI3-δ/γ Inhibitor, Intellikine (Intellikine); Gamma Inhibitor, Pathway Thera peutics (Pathway Therapeutics, Inc.); PI3-delta/gamma inhibitor, Pathway Therapeutics (Pathway Therapeutics, Inc.); PI3-gamma inhibitor, Evotec (Evotec); PI3-gamma inhibitor, Cellzome (Cellzome AG); Inhibitor, Pathway Therapeutics (Pathway Therapeutics Limited); PI3K δ/γ Inhibitor, Intellikine-1 (Intellikine); PI3K δ/γ Inhibitor, Intellikine-1 (Intellikine); Pictilisib ( Roche Holdings), PIK-90 (CAS No. 677338-12-4), SC-103980 (Pfizer, New York, N.Y.), SF-1126 (Semafore Pharmaceuticals, Indianapolis, Ind.), SH-5, SH-6 , Tetrahydrocurcumin, TG100-115 (Targegen, San Diego, Calif.), Triciribine (Triciribine), X-339 (Xcovery, West Palm Beach, Fla.), XL-499 (Evotech, Hamburg, Germany), its pharmaceutically acceptable salts and combinations thereof.

Additional agents in combination therapy may be poisons or venoms of plant or animal origin. Examples are diphtheria toxin or parts thereof. In other examples, the additional agent may be a "radioactive species," that is, a radioactive substance administered to the patient, such as intravenously or orally, which then penetrates through the patient's normal metabolism into the target organ or tissue, where it It delivers localized radiation in tissue for short periods of time. Examples of radionuclides include, but are not limited to, I-125, At-211, Lu-177, Cu-67, I-131, Sm-153, Re-186, P-32, Re-188, In-114m, and Y- 90.

The term "immunomodulator" means a substance that alters the immune response by enhancing or decreasing the ability of the immune system to produce antibodies or sensitized cells that recognize and react with the antigen that triggered its production. Immunomodulators can be recombinant, synthetic, or natural agents, and include cytokines, corticosteroids, cytotoxic agents, thymosin, and immunoglobulins. Some immunomodulators occur naturally in the body, and some of these immunomodulators are useful in pharmacological formulations. Examples of immunomodulators include, but are not limited to, granule colony stimulating factor (G-CSF), LAG-3, IMP-321, JCAR-014, ASLAN-002 (BMS-777607), interferon, imiquimod ) and cell membrane fractions from bacteria, IL-2, IL-7, IL-12, CCL3, CCL26, CXCL7, synthetic cytosine-guanosine (CpG), immune checkpoint inhibitors, and combinations thereof. Targeted cytokine therapy targeting especially lymphotoxin and LiGHT may also be used in combination with the composition of the invention.

In some combination treatments, the additional agent may be a "radiosensitizer" that makes tumor cells more sensitive to radiation therapy. Examples of radiosensitizers include misonidazole, metronidazole, tirapazamine, and trans-sodium crocetin, and combinations thereof.

In yet other embodiments, the additional agent is an "anti-angiogenic" agent that reduces or inhibits the growth of new blood vessels such as vascular endothelial growth factor (VEGF) inhibitors and endothelial cell migration inhibitors. Antiangiogenic agents include, but are not limited to, 2-methoxyestradiol, angiostatin, bevacizumab, cartilage-derived inhibitor of angiogenesis, endostatin, IFN-α, IL-12, itraconazole ( itraconazole), linomide, platelet factor-4, prolactin, SU5416, suramin, tasquinimod, tecogalan, tetrathiomolybdate, thalidomide Thalidomide, thrombospondin, thrombospondin, TNP-470, ziv-aflibercept, pharmaceutically acceptable salts thereof, prodrugs, and combinations thereof.

In particularly preferred embodiments, the HER2-targeting bispecific composition of the present invention can be combined with checkpoint inhibitors such as anti-PD-1/anti-PD-L1 compositions, CTLA-4, OX40 and their analogs . In specific embodiments of such combination therapy, compositions of the invention may be combined with antagonists of the cell surface receptor programmed cell death protein 1 (also known as PD-1 ) and antagonists of PD-L1 .

PD-1 plays an important role in downregulating the immune system and promoting self-tolerance by inhibiting T cell inflammatory activity. Binding of PD-1 ligands PD-L1 and PD-L2 present in T cells to PD-1 receptors inhibits T cell proliferation and cytokine production. Upregulation of PD-1 ligands occurs in some tumors, and signaling through this pathway may contribute to the suppression of active T cell immune surveillance of tumors. Anti-PD-1 antibodies bind to the PD-1 receptor and block its interaction with PD-L1 and PD-L3, thereby releasing PD-1 pathway-mediated suppression of immune responses, including anti-tumor immunity reaction.

Those skilled in the art are aware of the various anti-PD-1 antibodies that can be used. In some embodiments, an exemplary anti-PD-1 antibody used in combination with the compounds of the invention is pembrolizumab (Keytruda®). In other embodiments, the anti-PD-1 antibody used in combination with the compounds described above is nivolumab (Opdivo®). In other embodiments, the anti-PD-1 antibody used in combination with the compounds described above is Piritizumab (Medivation).

Additional PD-1 antibodies known to those skilled in the art include AGEN-2034 (Agenus), AMP-224 (Medimmune), BCD-100 (Biocad), BGBA-317 (Beigene), BI-754091 (Boehringer Ingelheim), CBT -501 (Genor Biopharma), CC-90006 (Celgene), cemiplimab (Regeneron Pharmaceuticals), durvalumab+MEDI-0680 (Medimmune), GLS-010 (Harbin Gloria Pharmaceuticals), IBI- 308 (Eli Lilly), JNJ-3283 (Johnson & Johnson), JS-001 (Shanghai Junshi Bioscience), MEDI-0680 (Medimmune), MGA-012 (MacroGenics), MGD-013 (Marcogenics), Pazopanib (pazopanib) hydrochloride + pembrolizumab (Novartis), PDR-001 (Novartis), PF-06801591 (Pfizer), REGN-2810 (Regeneron), SHR-1210 (Jiangsu Hengrui Medicine Company), TSR-042 ( Tesaro), LZM-009 (Livzon Pharmaceutical Group) and ABBV-181 (AbbVie). Each possibility represents an independent embodiment of the invention.

In a preferred embodiment, for the combination therapy of the present invention, the anti-PD-1 antibody is pembrolizumab (Keytruda®).

In other embodiments, compositions of the invention are combined with anti-PD-L1 antibodies. Exemplary such anti-PD-L1 antibodies for use in the combinations of the invention may be selected from the group consisting of durvalumab (MedImmune LLC), atezolizumab (Hoffmann-La Roche Ltd, Chugai Pharmaceutical Co., Ltd.), Avelumab (Merck KGaA), CX-072 (CytomX Therapeutics Co., Ltd.), BMS-936559 (ViiV Healthcare Co., Ltd.), SHR-1316 (Jiangsu Hengrui Medicine Co., Ltd.), M-7824 ( Merck KGaA), LY-3300054 (Eli Lilly and Co), FAZ-053 (Novartis AG), KN-035 (AlphaMab Limited), CA-170 (Curis), CK-301 (TG Therapeutics), CS- 1001 (CStone Pharmaceuticals Co., Ltd.), HLX-10 (Shanghai Henlius Biotech Co., Ltd.), MCLA-145 (Merus NV), MSB-2311 (MabSpace Biosciences (Suzhou) Co., Ltd.), and MEDI-4736 (Medimmune).

In certain other embodiments, the combination therapies of the invention may include other HER2-directed therapies. For example, it may be advantageous to combine a composition of the invention with trastuzumab and related HER2-based therapies (ie, therapies targeting trastuzumab epitopes), such as trastuzumab mAbs, trastuzumab-based ADCs, Kadekla, Enhertu; HER2 tyrosine kinase inhibitors such as lapatinib, neratinib, Tuca Tucatinib; immune conjugates targeting HER2, such as TLRs; and cytokines. Other immunotherapies and checkpoint inhibitor-based therapies that may be used in combination with the compositions of the invention include CTLA4, TIGIT, OX40, PD1, PDL1, TIM3-based therapies. The composition of the present invention can be further combined with CAR-T, NK or T cell based therapy and immunotherapy vaccine. Combinations with interleukins and interleukin-targeting therapies are also contemplated. Attention can be TGFb, VEGF and VEGFR1-3 and anti-angiogenic targeted therapy such as Avastin (Avastin), Ramucirumab (Ramucirumab) or such as axitinib (axitinib), lenvati The use of tyrosine kinase inhibitors such as lenvatinib, cabozantinib, regorafenib, sunitib, and sorafenib. In other embodiments, CDK4/6 inhibitors such as palbocoxib and its analogs may be used. EGFR inhibitors such as cetuximab, panitumumab, erlotinib and osimertinib may also be used in combination therapy.

The following are examples of compositions and evaluations of compositions of the invention. It is understood that various other embodiments may be practiced, given the general description provided above. example Example 1. Design of barcoded XTEN from universal XTEN with minimal mutations

This example illustrates an exemplary design approach for barcoded XTENs with minimal mutation(s) to the amino acid sequence of a universal XTEN, such as the one in Table 3b above. Relevant criteria for performing minimal mutation(s) include one or more of: (a) minimizing sequence changes corresponding to XTEN; (b) minimizing amino acid composition changes corresponding to XTEN; (c) substantially maintain the net charge of the corresponding XTEN; (d) substantially maintain the low immunogenicity of the corresponding XTEN; (e) substantially maintain the pharmacokinetic properties provided by the XTEN.

For example, barcoded XTENs were constructed by performing one or more mutations to the universal XTEN in Table 9 , the one or more mutations comprising deletion of glutamic acid residues, insertion of glutamic acid residues, glutamic acid residues The residues are substituted or substituted for glutamic acid residues or any combination thereof. Table 9. Four Generic XTENs for Engineered XTENs with Barcodes SEQ ID NO. XTEN name amino acid sequence 676 AE144 GSEPATSGSETPGTSESATPESGPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGSEPATSGSETPGSEPATSGSETPGSEPATSGSETPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAP 677 AE288_1 GTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGPSEPATSGSETPGSPAGSPTSTEEGSPTSTEPSSEPGTSEPG 678 AE576 GSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAP 679 AE864 GSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAP Example 2. Sequence analysis of barcoded XTENs and their selection for fusion with biologically active polypeptides ("BPs")

This example illustrates the design and selection of barcoded XTENs for fusion to biologically active polypeptides (and the assembly of more than one barcoded XTEN into a set). Depending on the location of the barcode segment(s) within the XTEN(s) and the manner in which the XTEN(s) are fused to the biologically active protein to form an XTEN-containing construct such as the XTEN-activated protease-activated T-cell engager (XPAT), The barcode fragment(s) may indicate truncation(s) of XTEN.

In silico GluC digestion analysis was performed on two exemplary XTENs (XTEN864 and XTEN288_1) to identify releasable peptide fragments following complete digestion of the XTEN by GluC. In silico analysis will take into account that, for XTENs with consecutive glutamate residues (eg, "EE"), GluC can be cleaved after any of the glutamate residues. As shown in the results summarized in Table 10 below, the 10-mer peptide sequence "TPGTSTEPSE" (SEQ ID NO: 96) and the 14-mer peptide sequence "GSAPGSEPATSGSE" (SEQ ID NO: 97) each occur once in the longer XTEN864 and only once, while all other peptide sequences appeared two or more times in XTEN864. And the 14-mer peptide sequence "GSAPGSEPATSGSE" (SEQ ID NO: 97) also appeared once and only once in the shorter XTEN288_1.

Candidate barcodes were assessed for uniqueness relative to all other peptide fragments that could be released from the XTEN-containing constructs. Thus, a barcode sequence in one XTEN cannot occur anywhere else in an XTEN-containing construct, including between any other XTEN contained therein, any biologically active protein contained therein, or its adjacent components. any connections. For example, Table 11 shows a list of peptide "uniqueness" for the set of two XTENs. Since the 14-mer peptide sequence "GSAPGSEPATSGSE" (SEQ ID NO: 97) is present in both XTEN864 and XTEN288, it is not unique to the group of XTENs comprising both XTEN864 and XTEN288, and therefore, may not be used In detecting truncated barcodes in polypeptide products containing both XTEN sequences.

Selecting a code (or set of barcodes) may further involve identifying and determining the appropriate location(s) of the candidate barcode(s) within the XTEN. The location of candidate barcodes can be correlated with pharmacologically relevant information for XTEN (and XTEN-containing constructs as a whole), such as truncations of XTEN beyond critical lengths and/or deletion(s) in the XTEN sequence . If XTEN864 is placed at the N-terminus of the XTEN-containing product and if the truncation of 238 amino acids from the N-terminus of the product does not significantly affect the pharmacological properties of the product, the 10-mer peptide "TPGTSTEPSE" (SEQ ID NO : 96) can serve as a suitable barcode segment. Table 10. Representative XTEN sequences for in silico GluC digestion analysis Exemplary XTEN amino acid sequence XTEN864 GSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSE TPGTSTEPSE GSAPGSEPATSGSE TPGTSESATPESGPGTSTEPSEGSAP (SEQ ID NO: 98) AE288_1 GTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSE GSAPGSEPATSGSE TPGTSESATPESGPGTSTEPSEGSAP (SEQ ID NO: 99) Table 11. Peptide "uniqueness" analysis peptide fragment SEQ ID NO: XTEN AE288_1 XTEN864 both SATPE 125 9 twenty three 32 SGPGSEPATSGSE 126 4 9 13 GSAPGTSTESE 127 1 10 11 TPGTSE 128 4 7 11 SGPGTSTEPSSE 129 2 8 10 GSAP GTSE 130 1 8 9 GT STEP SE 131 2 5 7 GSAPGSPAGSPTSTEE 132 1 4 5 GSPAGSPTSTEE 133 1 4 5 SGP GTSE 134 2 3 5 SGPGSPAGSPTSTEE 135 1 3 4 TPGSEPATSGSE 136 1 2 3 TPGSPAGSPTSTEE 137 1 2 3 GSAPGSEPATSGSE 138 1 1 2 TPGTSTEPSSE 139 1 1 All underlined sequences generate unique GluC peptides Non-XTEN core underlined and italicized barcode Peptides in bold

Exemplary barcoded peptide sequences are depicted in Table 12 below. These barcode sequences should be flanked according to the structural formula (I): AAA-Glu-barcode peptide-BBB, wherein "AAA" means Gly, Ala, Ser, Thr or Pro and "BBB" means Gly, Ala, Ser or Thr, It is configured for efficient release of barcoded peptides by GluC digestion. Notably, insertion of each barcode peptide into the XTEN can generate additional unique sequences directly preceding or following the inserted barcode peptide. Table 12. List of non-limiting examples of barcoded peptides Candidate barcoded peptide(s) SEQ ID NO: SPATSGSTPE 140 GSAPATSE 141 GSAP GTATE 142 GSAPGTE 143 PATSGPTE 144 SASPE 145 PATSGSTE 146 GSAPGTSAE 147 SATS GSE 148 SGPGSTPAE 149 Example 3: Design and Selection of XTEN(s) in Fully Sequence XTENylated Polypeptide Constructs

This example illustrates the design of a full sequence polypeptide construct containing two XTENs, one at the N-terminus and the other at the C-terminus.

Table 13 below illustrates the XTEN sequences used in a representative barcoded BPXTEN (containing a barcoded XTEN at both the N- and C-terminus) and a reference BPXTEN (containing a universal XTEN at both the N- and C-terminus). In a representative barcoded BPXTEN, a barcoded XTEN ( SEQ ID No. 8014 ) was fused at the N-terminus of the BP, and another barcoded XTEN ( SEQ ID No. 8015 ) was fused at the C-terminus of the BP. In the reference BPXTEN, the "Ref-N" XTEN was fused at the N-terminus of the BP, and the "Ref-C" XTEN was fused at the C-terminus of the BP. The length of "Ref-N" XTEN is equivalent to the length of XTEN SEQ ID No. 8014 with barcode; and the length of "Ref-C" XTEN is equivalent to the length of XTEN SEQ ID No. 8015 with barcode. The barcoded BPXTEN and the reference BPXTEN each contain a reference sequence in the BP component. The reference sequence is unique and differs from all other peptide fragments that can be released from the corresponding BPXTEN after complete GluC protease digestion by molecular weight (eg according to Example 5 ). The uniqueness of the reference sequence was assessed relative to all other peptide fragments that could be released from the BPXTEN construct. Table 13. Representative N-terminal XTEN and C-terminal XTEN groups used in full-length BPXTEN constructs *Barcoded peptides in bold All underlined sequences result in unique GluC peptides; SEQ ID NO. XTEN type amino acid sequence Total number of AAs 8014 (from Table 3a ) N-terminal XTEN SPAGSPTSTESGTSE SATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPE SGPGSTPAESGSE TPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTEEGSPAGSPTTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPEPSGPGSEPATSGSETPGSPAGTSAPGSAPGSAPGSAPGS 292 8015 (from Table 3a ) C-terminal XTEN PGSPAGSPTSTEE GTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSE GSAPGTE STPSEGSAPGSEPATSGSE TPGTSESATPESGPGTSTEPSE GSAPGEPEA 582 8021 Ref-N N-terminal XTEN SPAGSPTSTEE GTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSEGSPTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSEPSSEGSPEGSPASTGTAPSAPG 292 8022 Ref-C C-terminal XTEN PGSPAGSPTSTEE GTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSE TPGTSTEPSE GSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSE GSAPGAAEPEA 584 Example 4: Recombinant construction and production of XTENized fusion polypeptide with barcode

Example 4 illustrates the recombinant construction, production and purification of an XTENylated fusion polypeptide containing a barcoded XTEN at the C-terminus and another barcoded XTEN at the N-terminus using the methods disclosed herein.

Representation: Encoding contains anti-CD3 sequence (such as described in Table 6a-6e ), anti-HER2 sequence (such as described in Table 6f ), a barcoded XTEN at the C-terminus (such as described in Table 3a ) and at N The construction of an XTENylated fusion polypeptide with a barcoded XTEN at the terminus (such as described in Table 3a ) was expressed in a dedicated E. coli AmE098 strain and via the N-terminal secretory leader (MKKNIAFLLASMFVFSIATNAYA) (SEQ ID NO: 100 ) is partitioned in the periplasm, which is cleaved during translocation. Fermentation cultures were grown at 37°C with complex animal-free medium and the temperature was shifted to 26°C prior to phosphate depletion. During harvest, the fermented whole broth was centrifuged to pellet the cells. At harvest, total volume and wet cell weight (WCW; ratio of pellets to supernatant) were recorded, and pelleted cells were collected and frozen at -80°C.

Recovery: Frozen cell pellets were resuspended in lysis buffer (100 mM citric acid), aiming at 30% wet cell weight. The resuspension was equilibrated at pH 4.4, followed by homogenization at 17,000±200 bar while monitoring and maintaining the outlet temperature at 15±5°C. The pH of the homogenate was confirmed to be within the specified range (pH 4.4±0.1).

Clarification: To reduce endotoxin and host cell impurities, the homogenate was subjected to low temperature (10±5°C), acidic (pH 4.4±0.1) flocculation overnight (15-20 hours). To remove the insoluble fraction, the floc homogenate was centrifuged at 8,000 RCF and 2-8°C for 40 minutes, and the supernatant was retained. To remove nucleic acids, lipids and endotoxins and act as a filter aid, the supernatant was adjusted to 0.1% (m/m) diatomaceous earth. To keep the filter aid in suspension, the supernatant was mixed via an impeller and allowed to equilibrate for 30 minutes. Assemble a filter train consisting of a depth filter followed by a 0.22 µm filter followed by an MQ rinse. The supernatant was pumped through the filter train while adjusting flow to maintain a pressure drop of 25 ± 5 psig.

purification

Protein-L capture: To remove host cell proteins, endotoxins and nucleic acids, protein-L was used to capture the kappa domain present within the aHER2 scFv of the BPXTEN molecule. In this paper, protein-L stationary phase (Tosoh TP AF-rProtein L-650F), protein-L mobile phase A (11.5 mM citric acid, 24.5 mM Na₂HPO₄, 125 mM NaCl, 0.005% polysorbate 80, pH 5.0) and Protein-L Mobile Phase B (11 mM phosphoric acid, 0.005% polysorbate 80, pH 2.0). Equilibrate the column with Protein-L Mobile Phase A. The filtrate was adjusted to pH 5.5±0.2 and loaded onto a protein-L column with a target of 2-4 g/L-resin, followed by additional protein-L mobile phase A until the absorbance at 280 nm (A280) returned to (local ) baseline. Bound material was eluted with mobile phase B and collected as 2 CV fractions pre-spiked with 0.4 CV of 0.5 M Na2HPO₄ and analyzed by SDS-PAGE.

C-tag intermediate purification: To ensure C-terminal integrity, the C-terminal-EPEA tag was captured using C-tag affinity chromatography. In this paper, C-tag stationary phase (Thermo C-tagXL), C-tag mobile phase A (50 mM histidine, 200 mM NaCl, 0.005% polysorbate 80, pH 6.5) and C-tag mobile phase B ( 20 mM Tris, 0.6 M MgCl₂, 0.005% polysorbate 80, pH 7.0). Equilibrate the column with C-label mobile phase A. The IMAC eluent was loaded onto a C-tag column targeting 2 g/L-resin, and additional C-tag mobile phase A was added until the absorbance at 280 nm (A280) returned to the (local) baseline. Elute bound material with C-labeled mobile phase B. C-tag eluates were collected as 2 CV fractions and analyzed by SDS-PAGE.

AEX Polishing: To separate dimers and aggregates from monomeric products, anion exchange (AEX) chromatography was used to capture the negatively charged N-terminal and C-terminal XTEN domains. AEX1 stationary phase (BIA QA-80), AEX1 mobile phase A (50 mM histidine, 200 mM NaCl, 0.005% polysorbate 80, pH 6.5) and AEX1 mobile phase B (50 mM histidine, 500 mM NaCl, 0.005% polysorbate 80, pH 6.5). Equilibrate the column with AEX mobile phase A. The C-tag eluent was diluted to 10 mS/cm with MQ, loaded with a target of 2 g/L-resin, and then additional AEX mobile phase A was added until the absorbance at 280 nm returned to the (local) baseline. Bound material was eluted using a gradient from 0% B to 100% B over 60 CV. Eluate was collected in 1 CV aliquots when A280 was ≥ 2 mAU above (local) baseline. Fractions were analyzed by SDS-PAGE and SE-HPLC, and those found to be > 98% monomer were pooled (AEX pool) for further processing.

Formulation: To exchange the product into the formulation buffer and bring the product to the target concentration (0.5 g/L), ultrafiltration/diafiltration (UF/DF) was used. Using a 10 kDa membrane with an area of 0.1 m² and a TMP target of 15 psi, the AEX pool was concentrated to 0.5 g/L and then filled with conditioning buffer (50 mM histidine, 200 mM NaCl, 0.005% polysorbate 80 , pH 6.5) was diluted 10 times. The AEX pool was concentrated 10-fold and re-diluted 10-fold twice. The recovered formulated product was 0.22 µm filtered in the BSC, aliquoted, labeled and stored as Bulk Drug Substance (BDS) at -80°C. Confirm that the BDS meets all batch release criteria by various analytical methods. Overall quality was analyzed by SDS-PAGE, ratio of monomers to dimers and aggregates by SE-HPLC, and N-terminal quality and product homogeneity by HI-HPLC. Identity was confirmed by ESI-MS. Example 5. Release of barcoded peptides by protease digestion

This example illustrates the release of barcode fragment(s) and reference fragment(s) from a mixture of polypeptides containing XTEN-containing constructs of different lengths or truncated forms using the methods disclosed herein.

Samples containing XTEN constructs were reduced and alkylated by sequential incubation in DTT followed by iodoacetamide. Samples were then buffer exchanged and desalted using size exclusion spin filter cartridges. Glu-C protease was added to the samples at an enzyme:substrate ratio of 1:5 and the samples were incubated at 37°C for digestion. Subsequently, samples were moved to 4°C to stop proteolytic reactions and placed in autosampler vials for analysis. Example 6. Detection and Quantification of Barcode Peptide(s) and Reference Peptide(s)

This example illustrates mass spectrometry used to generate quantitative measurements of individual barcoded peptides. The LC-Parallel Reaction Monitoring (PRM) method was programmed into a High Resolution Accurate Mass (HRAM) mass spectrometer. Unlike traditional data-dependent acquisition (DDA) mass spectrometry, the PRM method focuses on a specific set of 15-30 peptides in one run, and each peptide is sequenced by MS-MS once per work cycle. Thus, this method generates extracted ion chromatograms (XIC) of the unfragmented precursor ion of the intact peptide as well as the individual fragment ions of the peptide to confirm its sequence. Fragment ion XIC is often quantified more sensitively and selectively than precursor ion fragments. The LC-PRM method used included light and heavy chain versions of the seven barcoded peptides. The chromatographic peak areas of all fragment ions of these 14 peptides were measured after acquisition and the strongest fragment ion was used for quantitative measurement. Next, the peak area ratios of XTEN barcoded peptides to PAT barcoded peptides were calculated for the relative XTEN:PAT abundance at each point in the XTEN molecule. Example 7. Stable isotope labeling for quantification of peptides by mass spectrometry (MS)

This example illustrates a stable isotope labeling scheme that enables absolute (rather than relative) quantification of barcoded peptides from XTEN-containing polypeptides. Synthetic analogues of barcoded peptides in which the C-terminal glutamic acid is replaced by ( ¹³ C) ₅ H ₇ ( ¹⁵ N)O ₃ heavy chain tagged analogs will be obtained from specific suppliers using standard heavy chain tagged amino acid quantitation protocols . A calibration curve will be prepared in which polypeptides containing known amounts of XTEN barcodes are serially diluted into a matrix in which the heavy chain-tagged synthetic peptide is maintained at a constant concentration. Precise quantification can be performed by chromatographic peak area heavy chain:light chain ratios against calibration curves of research samples containing heavy chain labeled peptides with the same spine content. Example 8. Quantification of truncations of XTEN-containing polypeptides

This example demonstrates the quantification of length variants or truncated variants in mixtures containing XTEN polypeptides.

For example, the barcoded peptide "SGPGSTPAESGSE" (SEQ ID NO: 150) is located at 76 amino acids in the representative barcoded BPXTEN sequence described in and obtained from Example 3 to indicate that the XTEN is at the N-terminus of the BPXTEN harsh truncation. The potential barcode fragment "SPAGSPTSTESGTSE" (SEQ ID NO: 151 ), which is located at the N-terminus, was also considered. Following the procedure of Example 6 , the abundance measurement of each barcoded peptide relative to a unique reference peptide sequence derived from a biologically active protein (e.g., scFv fragment) sequence is indicative of the full-length polypeptide and has a cutoff that may affect pharmacological efficacy in the sample mixture. Total amount of short variants. The abundance measurement of at least one reference fragment is used to indicate the total amount of all variants of the polypeptide in the sample mixture. Thus, the differential abundance between the reference fragment and the barcode fragment informs the amount of the truncated polypeptide variant. The LC-MS data are analyzed to determine the ratio of the amount of barcode fragments to reference fragments, which is indicative of the relative amount of pharmacologically effective variants in the polypeptide mixture.

A set of two (or three) barcodes is used to indicate polypeptide truncations at different positions. LC-MS data were used to determine the ratio of the amount of each barcode fragment to the amount of the reference fragment, thereby quantifying the distribution of truncating variants in the polypeptide mixture. Example 9. In vitro cytotoxicity of XTENylated (masked) XPAT and de-XTENylated (unmasked, activated) XPAT (protease-activated T cell engager) against target cells

This example demonstrates the shielding of XTEN on the XTENylated protease-activated T-cell engager ("XPAT") in general and on HER2-XPAT in particular. This example illustrates the difference in cytotoxicity of XTENylated (masked) HER2-XPAT (eg, as set forth in Table D) and the corresponding deXTENylated (unmasked) HER2-PAT.

Cytotoxicity of XTENyPAT (as set forth in Table D) and corresponding de-XTENyPAT (protease treated) was determined using an in vitro cytotoxicity assay utilizing the ATP present in wells of target cells lysed after treatment The amount was used as a representative measure of cell viability. HER2-expressing target cells were seeded at different densities (BT474: 20k cells/well and SKOV3: 10k cells/well) _on white opaque bottom plates and incubated overnight (18-24 Hour). Peripheral blood mononuclear cells (PBMCs) were thawed and incubated overnight at 37°C, 5% CO ₂ before the end of the overnight incubation. PBMC were isolated from screened healthy donors by Ficoll density gradient centrifugation from whole blood or lymphocyte-enriched skin-colored blood layer preparations obtained from BioIVT. A 10× XTENylation and de-XTENylation PAT titration was prepared using a 9-point, 3-fold titration (point 10 is no treatment), where the starting concentration of XTENylation PAT was 2400 nM and the starting concentration of de-XTENylation PAT was 10 nM . PBMCs were seeded into the wells at a 1:1 effector:target ratio. Titrate 10-fold dilutions of 10× XTENylation PAT and de-XTENylation PAT into the wells, starting at 240 nM and 1 nM, respectively. Plates were incubated for 48 hours at 37°C, 5% _CO2 . After the 48 hour incubation, the plates were washed 3 times with 1×PBS, and 100 μL of 1×PBS was added to all wells. Add 100 µL of CellTiter-Glo® Fluorescent Substrate Solution to all wells and incubate the plate at room temperature for 1-5 minutes. The plate was then shaken on a plate shaker at 300-500 rpm for 30-60 seconds to mix the contents of the wells and then read photometrically using an integration time of 100 ms. The intensity of the signal generated correlates with the amount of viable cells present in the well. The mean value of the signal from all non-treated wells was calculated and used to determine the % viable cells of the treated wells ((mean of treated signal/non-treated signal) x 100 = % viable). % survival was plotted by concentration, and half-maximal response (EC50) values were derived with a 4-parameter logistic regression equation using GraphPad Prism software.

XTENylated PAT and the corresponding de-XTENylated PAT exhibited large differences in cytotoxicity across all HER2-expressing cell lines tested, confirming that XTENylated resulted in reduced cytolytic activity (inactivated state) of masked bispecific antibodies. As shown in Figures 5A-5B , cytotoxicity of deXTENylated (unmasked, activated) PAT on BT-474 and SK-OV-3 cells was observed in a dose-dependent manner, where ~ 80% of the maximum kill. As shown in Figures 5A-5B , de-XTENyPAT exhibited EC50 values of 4.8 pM (BT474) and 3.4 pM (SKOV3), while XTENyPAT exhibited EC50 values of 49,370 pM (BT474) and 44,474 pM (SKOV3). The observations confirmed that de-XTENylated HER2-PAT has cytotoxic activity on HER2-expressing cell lines, and that XTENylated masks (or shields) can form immune synapses, thereby causing reduced cytotoxicity. Example 10. In vitro cytotoxicity of XTENylated (masked) XPAT and de-XTENylated (unmasked, activated) XPAT against target cells expressing low levels of target antigen

Example 10a:

Normal human cardiomyocytes express low levels of HER2, and thus, rare cases of cardiotoxicity have been observed in patients treated with some HER2-targeting therapies. Given the known cardiotoxic potential of agents targeting HER2, AMX-818 toxicity was assessed against HER2 expressing human cardiomyocytes. Consistent with the absence of cardiotoxicity in non-human primate (NHP) preclinical studies, AMX-818 exhibited limited cytotoxicity in vitro on human cardiomyocytes, even at micromolar doses. In contrast, the unmasked TCE counterpart exhibited significantly greater cytotoxic activity (EC50 of ~100 pM)

This example demonstrates the sensitivity of primary cardiomyocytes to T cell-directed cytotoxicity in response to increased concentrations of HER2-XPAT (such as described in Table D) and its active proteolytic product, ie, the corresponding HER2-PAT.

Normal human cardiomyocytes purchased from FujiFilm Cellular Dynamics were used. Cardiomyocytes (iCell cardiomyocytes, Cellular Dynamics International) were revived from liquid nitrogen and plated at 20,000 cells/96 well for 7 days and processed according to manufacturer's instructions. Human peripheral blood lymphocytes were added to iCell cardiomyocytes at a 1:1 effector:target ratio with a 3-fold increase in the concentration of XTENylated HER2-XPAT or the corresponding de-XTENylated HER2-PAT and at 37°C, 5% CO Incubate at ₂ for 48 hours. Assays were performed in RPMI (Roswell Park Memorial Institute) medium with 10% heat-inactivated fetal bovine serum. Cardiomyocyte cell viability was quantified via ATP and performed with the Cell Titer-Glo Luminescent Cell Viability Assay System (Promega). Cell supernatant was aspirated and cells were washed twice with phosphate buffered saline (PBS), aspirated and then PBS was added (100 μl/well). Automated dish washing was performed using a LS405 micro-quantitative dish washer dispenser (BioTek). Add Cell Titer-Glo reagent (100 µl/well) and incubate the assay plate at room temperature for 5 minutes. Luminescence was quantified with a multilabel reader (Molecular Devices) and a luminescence detector. For cytotoxicity assays, % viable cells were calculated from relative luminescence units (RLU). Survival % = (RLU of test wells/RLU of target cells only) × 100. For _EC50 determinations, data were converted in Microsoft Excel and analyzed with Graph Pad Prism 8.3.1 software 'log(agonist) versus response variable slope (four parameters).

As shown in Figure 6A , cardiomyocytes were killed by T cell-directed cytolysis in response to deXTENylated HER2-PAT at an EC50 concentration of approximately 64 pM, while cardiomyocytes remained refractory to XTENylation at concentrations up to 1 µM Treatment with HER2-XPAT killing demonstrated that XTENylated PAT activity was lower in cardiomyocytes compared to cancer cell lines.

Example 10b : This example illustrates another cell line MCF7 with a relatively low level of HER2 expression in response to increased concentrations of HER2-XPAT (such as described in Table D) and its active proteolyzate, ie the corresponding HER2-PAT Sensitivity to T cell-directed cytotoxicity.

MCF-7 cells were cultured according to established protocols. Concentration-response curves and EC50 values were measured and analyzed according to the method outlined in Example 10a.

As shown in Figure 6B , MCF-7 cells were efficiently killed by T cell-directed cytolysis in response to EC50 concentrations between 0.01 nM and 0.1 nM of proteolytically deXTENylated HER2-XPAT (closed circles) . XTENylation on HER2-XPAT (eg, as described in Table D) reduced T cell-mediated cytotoxicity by at least 104 ^- fold, as indicated by a rightward shift of the dose-response curve (solid squares).

Example 10c:

This example illustrates that MDA-MB-453, another cell line expressing moderate levels of HER2, responds to increased concentrations of HER2-XPAT (such as described in Table D) and its active proteolytic product, i.e., the corresponding HER2-PAT. Sensitivity to T cell-directed cytotoxicity. MDA-MB-453 is a breast cancer cell line with moderate HER2 expression.

Cytotoxicity of XTENyPAT (as set forth in Table D) and corresponding de-XTENyPAT (protease treated) was determined using an in vitro cytotoxicity assay utilizing the ATP present in wells of target cells lysed after treatment The amount was used as a representative measure of cell viability. Target cells expressing HER2 (MDA-MB-453 strain) were seeded at 10k cells/well on white opaque bottom dishes and incubated overnight (18-24 hours) at 37°C, 5% CO ₂ . Peripheral blood mononuclear cells (PBMCs) were thawed and incubated at 37°C, 5% _CO2 for 3-4 hours before the end of the overnight incubation. PBMC were isolated from screened healthy donors by Ficoll density gradient centrifugation from whole blood or lymphocyte-enriched skin-colored blood layer preparations obtained from BioIVT. A 10x XTENyL and deXTENyPAT titration was prepared using a 7-point, 5-fold titration with a starting concentration of 3000 nM for XTENyPAT and 10 nM for deXTENyPAT. PBMCs were seeded into the wells at a 10:1 effector:target ratio. Titrate 10-fold dilutions of 10× XTENylation PAT and de-XTENylation PAT into the wells, starting at 300 nM and 1 nM, respectively. Plates were incubated for 48 hours at 37°C, 5% _CO2 . After the 48 hour incubation, the plates were washed 3 times with 1×PBS, and 100 μL of 1×PBS was added to all wells. Add 100 µL of CellTiter-Glo® Fluorescent Substrate Solution to all wells and incubate the plate at room temperature for 1-5 minutes. The plate was then shaken on a plate shaker at 300-500 rpm for 30-60 seconds to mix the contents of the wells and then read in a photometer using an integration time of 100 ms. The intensity of the signal generated correlates with the amount of viable cells present in the well. The mean value of the signal from all non-treated wells was calculated and used to determine the % viable cells of the treated wells ((mean of treated signal/non-treated signal) x 100 = % viable). % survival was plotted by concentration, and half-maximal response (EC50) values were derived with a 4-parameter logistic regression equation using GraphPad Prism software.

Concentration-response curves for de-XTENylated HER2-XPAT (closed circles) and XTENylated HER2-PAT (closed squares) are shown in Figure 6C , respectively.

The HER2 expression levels of the cell lines tested herein are known in the art. For example, Hendriks et al. (Mol. Cancer Ther. 2013 Sep. 1;12(9):1816-1828), which is incorporated herein by reference in its entirety, details mean the various HER2 content of cells (X-axis indicates the number of HER2 receptors per cell). BT-474 may have a relatively high HER2 content of "3+" (immunohistochemical test score); cardiomyocytes may have a "2+" HER2 content; and MCF-7 may have a relatively low "1+/0" HER2 content. Example 11. Tumor regression induced in individuals by administration of XTENyXPAT

This example demonstrates tumor regression induced in individuals by administration of vehicle, non-cleavable XTENylated HER2-PAT, cleavable XTENylated HER2-PAT, and unmasked HER2-PAT. The non-cleavable constructs used in the experiments were the same as the corresponding cleavable constructs, but the release sites had been replaced by GASTEP amino acids (glycine, alanine, serine, threonine, glutamic acid and/or Proline) produced non-cleavable sequence substitutions of similar length.

Example 11a : One day before tumor inoculation, estrogen-packaging particles (17β-estradiol, 60-day release) were implanted into the right flank of mice. BT-474 tumor cells were inoculated subcutaneously in the right flank region of each mouse at a concentration of 2×10 ⁷ BT-474/200 μl RPMI 1640 and Matrigel (1:1)/mouse for tumor development. The date of tumor cell inoculation is represented as day 0 (D0).

When tumors became palpable on D8 (mean tumor volume (MTV) = 117 mm ³ ), PBMCs were implanted intravenously at 1×10 ⁷ PBMCs/200 μl RPMI 1640/mouse. One group of mice was not injected with PBMCs ("no hPBMC" group) and this group of mice underwent the remainder of the experimental treatment at the same time as the PBMC-injected mice. When the average tumor volume reached 147 mm ⁽ D10), vehicle (diluent) was administered to the "no hPBMC" group of mice (solid squares in Figure 7A ); and the PBMC-injected mice were randomly divided into four Each group was administered with vehicle (diluent) (solid circle in Figure 7A ), unmasked bispecific body (solid triangle in Figure 7A ), cleavable XTENylated bispecific body (solid triangle in Figure 7A ) and non-cleavable XTENylated bispecifics (diamonds in Figure 7A ). All five groups received equimolar doses of 15 nmol/Kg.

As depicted in Figure 7A , by the end of the study, i.e. D35, both the cleavable XTENylated HER2-PAT (eg, as set forth in Table D) and the unmasked bispecifics were comparable to the control (with or without Vehicle with hPBMC) and non-cleavable XTENylated bispecific counterparts exhibited significant antitumor efficacy when compared. The non-cleavable XTENylated bispecific constructs did not have any tumor growth inhibition supporting the following: The antitumor efficacy observed on the XTENylated HER2 bispecifics was driven by proteolytic cleavage.

Example 11b : An experimental setup similar to that described in Example 11a was implemented. One day before tumor inoculation, estrogen-harvesting granules (17β-estradiol, 60-day release) were implanted into the right flank of the mice. BT-474 tumor cells were inoculated subcutaneously in the right flank region of each mouse at a concentration of 2×10 ⁷ BT-474/200 μl RPMI 1640 and Matrigel (1:1)/mouse for tumor development. The date of tumor cell inoculation is represented as day 0 (D0). When tumors became palpable (MTV = 94 mm ³ ) on D8, PBMCs were implanted intravenously at 1×10 ⁷ PBMCs/200 μl RPMI 1640/mouse. One group of mice was not injected with PBMCs ("no hPBMC" group) and this group of mice underwent the remainder of the experimental treatment at the same time as the PBMC-injected mice. When the MTV reached 444 ^mm3 (D20), PBMC-injected mice were randomized into groups, and vehicle (diluent) and test article treatments were delivered as a single dose to all groups on D21.

Figure 7B shows that cleavable XTENylated HER2-XPAT (such as described in Table D) after a single dose even in larger established tumors (such as Significant antitumor efficacy in mean tumor volume (MTV) > 400 mm ³ ). The absence of appreciable levels of tumor growth inhibition by non-cleavable XTENylated HER2-PAT supports the following: The antitumor efficacy of cleavable XTENylated HER2-PAT is driven by proteolytic cleavage.

Example 11c : Examples 11a and 11b used xenografts generated from breast cancer cell lines expressing relatively high levels of HER2, in this example a tumor regression study was performed using a colorectal xenograft model characterized by low levels of HER2 expression. Mice were inoculated subcutaneously at the right flank region of each mouse for tumor development at a concentration of ⁵ x 106 HT-55/200 μl RPMI 1640 and Matrigel (1:1)/mouse. The date of tumor cell inoculation is represented as day 0 (D0).

When tumors became palpable on D6 (mean tumor volume (MTV) = 82 mm ³ ), PBMCs were implanted intravenously at 1×10 ⁷ PBMCs/200 μl RPMI 1640/mouse. One group of mice was not injected with PBMCs ("no hPBMC" group) and this group of mice underwent the remainder of the experimental treatment at the same time as the PBMC-injected mice. When the average tumor volume reached 130 mm ⁽ D10), vehicle (diluent) was administered to the "no hPBMC" group of mice (solid squares in Figure 7C ); and the PBMC-injected mice were randomly divided into five groups. Each group was administered with vehicle (diluent) (closed circles in Figure 7C ), 15 nmol/Kg unmasked bispecific (closed triangles in Figure 7C ), 15 nmol/Kg cleavable XTENCL Bispecifics (triangles in Figure 7C ), 36 nmol/Kg cleavable XTENylated bispecifics (hexagons in Figure 7C ), and non-cleavable XTENylated bispecifics (diamonds in Figure 7A ).

As depicted in Figure 7C , by the end of the study, both XTENylated HER2-PAT (such as described in Table D) and unmasked bispecifics (at both 15 nmol/Kg and 36 nmol/Kg) could be cleaved. ) exhibited significant antitumor efficacy when compared to controls (vehicle with or without hPBMCs) and non-cleavable XTENylated bispecific counterparts. The non-cleavable XTENylated bispecific constructs did not have any tumor growth inhibition supporting the following: The antitumor efficacy observed on the XTENylated HER2 bispecifics was driven by proteolytic cleavage.

In additional in vivo experiments, it was shown that HER2-XPAT (i.e., XTENylated or masked HER2-PAT) is preferentially unmasked in tumor tissue with significantly greater cleavage seen in tumor compared to normal tissue . BT-474 tumors were established in NSG mice. Mice were injected with HER2-XPAT site-specifically labeled with an IR dye. After a 2-day period, tissues (tumor, brain, heart, and liver) were harvested, homogenized, and BT-474 was assessed for the presence of unmasked HER2-PAT in each tissue. In addition, in order to determine whether cleavage/unmasking of HER2-XPAT occurs in vivo in the tumor or whether it is an artifact of tissue homogenization when the tissue has been harvested, differently labeled HER2-XPAT was added to the outside of the sample prior to sample preparation . Figure 7D demonstrates that HER2-XPAT is preferentially cleaved in tumor tissue over unmasked PAT compared to that seen in brain, heart and liver tissues. Furthermore, Figure 7D also demonstrates that lysis occurs in vivo in tissue as opposed to ex vivo, due to homogenization or other manipulations. In addition, there was strong evidence of XPAT cleavage in fresh tumor samples.

Examples 11a-11c demonstrate that cleavable XTENylated HER2-PAT induces robust tumor regression in tumor models expressing low levels of HER2 as well as tumors characterized as having high HER2 expression. Thus, no tumor regression was observed in test subjects treated with non-cleavable XPAT. Furthermore, the data presented herein demonstrate that, in the tumor microenvironment, HER2-XPAT is preferentially unmasked in vivo. The experimental design of Examples 11a-11c is further discussed in Example 17 below. Example 12. Lymphocyte landing induced in individuals by administration of XTENyXPAT

This example illustrates the administration of XTENylated HER2-PAT (e.g., as set forth in Table 6), e.g., by intravenous (IV) infusion of a single dose (e.g., at 25 mg/kg at a dose volume of 10 ml/kg) Lymphocyte bordering was induced in individuals (eg, female monkeys and male monkeys).

Test article dosing formulations were prepared by diluting the XPAT of interest according to established protocols to meet dose level requirements. Test articles (HER2-XPAT of interest) and appropriate diluents were provided as single-use aliquots and stored in a freezer set to maintain -80°C until use. Once thawed, aliquots were stored at 2°C-8°C and not refrozen. Dosing formulations are prepared on the day of dosing. On the day of use, aliquots of XPAT stock solutions and appropriate diluents were thawed at room temperature and appropriate amounts of test articles were diluted to obtain appropriate concentrations. Dosing formulations were mixed by gently inverting the tube several times. The IV exposure route was selected as the candidate class exposure route.

As shown in Figure 8 , HER2-XPAT-related changes in hematological parameters including lymphopenia (summarized in the table immediately below) following a single dose (25 mg/kg) were observed at 6 hours post-dose Started (0.5-0.2 x pre-dose level) and continued at 24 hours post-dose (0.27-0.1 x pre-dose level) and 48 hours after dosing (0.09-0.36 x pre-dose level). Lymphocyte levels remained low (0.3-0.1 x pre-dose levels) at 72 hours post-dose. Table 14. Hematology: Lymphocyte Changes Associated with HER2-XPAT Administration parameter point in time Dose (25 mg/kg) m f lymphocyte count Before administration 7.22 7.31 6 hours after administration 1.49 3.87 24 hours after administration 0.7 1.98 48 hours after administration 0.67 2.63 72 hours after administration 0.84 2.27 Example 13. Assessment of Toxicity and Pharmacokinetics of XTENylated PAT (XPAT) in Individuals

Toxicity and pharmacokinetics of XTENylated HER2-PAT (such as described in Table D) were assessed in cynomolgus monkeys. Animals were dosed with 25 mg/kg of cleavable XTENylated HER2-PAT or the corresponding non-cleavable XTENylated counterpart over 1 hour. Blood for plasma was collected before administration and at 5 minutes, 2 hours, 4 hours, 6 hours, 24 hours, 48 hours, 96 hours, 144 hours, 168 hours and 240 hours after the end of the infusion. All blood was collected at time +/- 2 minutes. Plasma samples were analyzed for the concentration of cleavable and non-cleavable XTENylated bispecific constructs. Plasma drug concentrations were measured by ECLIA (electrochemiluminescence immunoassay) using recombinant HER2 as capture and antibodies against the XTEN mask for detection. As shown in Figure 9 , in cynomolgus monkeys, HER2-XPAT (eg, as set forth in Table D) exhibited a pharmacokinetic profile similar to the corresponding non-cleavable form due to its stability in peripheral tissues. Were it not for the fact that the release site had been replaced by a non-cleavable sequence of similar length produced by GASTEP amino acids (glycine, alanine, serine, threonine, glutamic acid and/or proline), the experimental The non-cleavable constructs used were the same as the corresponding cleavable constructs. The presence of proteolytic metabolites in circulation after two independent doses was also monitored and is shown in Figure 9B as a percentage of total HER2-XPAT. As shown in Figure 9B , the presence of 1x metabolites was less than 4% of total HER2-XPAT. Example 14. XTEN Masked Amplification Safety Margins of HER2 - XPAT vs. HER2-PAT

Additional data showed that HER2-XPAT was well tolerated in cynomolgus monkeys and provided a 450-fold higher tolerance Cmax than that seen with unmasked PAT. HER2-XPAT was administered IV, single dose/animal (dose of 2.5-42 mpk) and twice weekly at 50 mpk. *At doses of 21 mpk and higher, a variant of HER2-XPAT with a shorter C-terminal XTEN mask was used. HER2-PAT is administered by continuous infusion due to its short half-life. Plasma concentrations of HER2-XPAT were measured by ECLIA* using recombinant HER2 captures and antibodies against the XTEN mask for detection. The Cmax values of HER2 PAT were determined by ECLIA using a-idiotypic Ab against a-CD3 scFv as capture and recombinant HER2 as detector. *ECLIA = electrochemiluminescence immunoassay. Figure 10A shows that at the maximum tolerated dose of 42 mg/kg, virtually no overt CRS was seen even at 50 mg/kg. In contrast, in Figure 10B , the maximum tolerated dose of unmasked HER2-PAT was 0.2 mg/kg. Figure 10C shows plasma concentrations of shielded HER2-PAT (at a 450-fold higher tolerated Cmax) compared to unshielded HER2-PAT.

In Figures 13A- 13B , there is additional evidence supporting the safety profile of the preferred HER2- XPAT of the present invention. HER2-XPAT or its non-cleavable counterpart, HER2-XPAT-non-cleavable site, was administered as a single IV dose of 25 or 42 mg/kg. Dose normalized plasma drug concentrations were measured by ECLIA* using recombinant HER2 as capture and antibodies against the XTEN mask for detection. *ECLIA = electrochemiluminescence immunoassay. The data in Figure 12A show comparable PK between HER2-XPAT and non-cleavable HER2-PAT formats, suggesting that even at high doses, the protease release site remains largely stable in the Cynomolgus monkey circulation. In Figure 12B, the concentrations of individually cleaved HER2-XPAT (1X-C) and HER2-XPAT (1X-N) were measured in plasma from cynomolgus monkeys administered HER2-XPAT. Western quantification was performed using an antibody recognizing anti-HER2 scFv using standards prepared from recombinant versions of the individually cleaved molecules. Results are expressed as percentage of total XTENylated species as measured by ECLIA as described above. Figure 12B shows that even at high doses of HER2 XPAT there is very limited systemic accumulation of metabolites not masked by one or two XTENs. Example 15. HER2-XPAT does not induce interleukin release syndrome

Consistent with the tolerance of HER2-XPAT, the present examples show that in a pilot NHP toxicology study, HER2-XPAT minimized activation of circulating T cells in NHP, even at a much lower The dose also caused significant T cell activation. Consistent with this masking of T cell activation, interleukin release following administration of HER2-XPAT was also robustly reduced relative to that observed for its unmasked counterpart. There was no overt cytokine release syndrome (CRS) in the case of HER2-XPAT, even at an MTD of 42 mg/kg, but its unmasked TCE counterpart resulted in CRS-induced disease at doses as low as 0.3 mg/kg. cause death. Overall, AMX-818 was well tolerated in the NHP study at doses that would be significantly higher than expected clinically relevant doses, with no overt or microscopic findings in HER2-expressing tissues such as the heart, where Other approved agents targeting HER2 have demonstrated clinical toxicity.

Thus, even at 50 mg/kg, administration of HER2-XPAT did not induce interleukin release or systemic T cell activation. This supports the following: XPAT presents the lowest CRS risk relative to standard TCE. Only 1-3% of the individually cleaved XPAT metabolites were detected in plasma from NHPs administered high doses of HER2-XPAT (25 and 42 mg/kg). For this study, peripheral T cell activation (CD25 ⁺ %) was assessed by flow cytometry 24 hours after HER2-XPAT treatment. 11A and 11B show CD25 ⁺ CD4 ⁺ T cells ( FIG. 11A ) and CD25 ⁺ CD8 ⁺ ( FIG. 11B ) T cells in the presence of HER2-XPAT versus HER2-PAT.

Interleukin analysis was performed on plasma samples using the Luminex® Suspension Array System. Figures 11C-11E show IL-6 ( Figure 11C ), TNF-a ( Figure 11D ) and IFN-g ( Figure 11E ) levels in plasma in response to HER2-XPAT versus HER2-PAT. Data presented are maximum measurements between 6-24 hours at each dose evaluated. In an additional GLP toxicology study (data not shown), AMX-818 was administered weekly to NHPs in 3 doses (0.5 mg/kg, 2 mg/kg, and 6 mg/kg) over a 31-day period. The results of these GLP toxicology studies were consistent with previous lead NHP studies, and based on standard toxicology endpoints including histopathological examination, there were no adverse findings related to AMX-818, and all clinicopathological findings were reversible.

Also consistent with the safety profile of AMX-818 in NHPs up to 42 mg/kg, AMX-818 is largely stable in protease inhibitor-replete circulation, as evidenced by limited systemic accumulation of active metabolites. Because individuals administered to healthy NHPs and to be treated with AMX-818 may also suffer from systemic inflammation , the stability of AMX-818 was determined by plasma samples obtained from patients with cancer and inflammatory diseases and our induced In vitro analysis of systemic inflammatory NHP. As shown in Figure 12 , AMX-818-like stability was observed in plasma samples from healthy NHPs, inflammatory NHPs, healthy humans, and human patients with cancer or inflammatory diseases in a stability study where We incubated AMX-818 with plasma samples at 37°C for seven days.

For this experiment, AMX-818 with a fluorescent label (DyL650) attached to the tandem scFv was incubated in the indicated plasma samples for seven days at 37°C. Subsequently, samples were run on a gel and metabolites similar in size to the unmasked active form of AMX-818 were quantified using a LI-COR detector. Inflammatory diseases Human samples were derived from patients with rheumatoid arthritis, lupus, inflammatory bowel disease and multiple sclerosis. Cancer human samples were derived from patients with lung, breast and colon tumors. Sample size: healthy NHP N=4, healthy human N=4, "inflamed" NHP N=6, "inflamed" human N=27, cancer human N=11.

In all four plasma groups, products similar in size to active unmasked HER2 TCEs ranged from only approximately 2% to 4% of the total AMX-818 species present. This small percentage reflects an overestimation of the potential in vivo accumulation of unmasked TCE, since renal filtration will rapidly eliminate these products from circulation (the half-life of the unmasked form in NHP is approximately seven hours). These data suggest that the risk of significant systemic accumulation of the active, unmasked form of AMX-818 in cancer patients is limited. Example 16. AMX-818 and 818-PAT induce PD-1 and CD69 surface expression on T cells in response to SKOV3 tumor cells

Surface PD-1 expression on CD4+ T cells and CD8+ T cells was assessed by flow cytometry after co-incubation of PBMC and SKOV3 cells with indicated concentrations of test articles at a 5:1 effector:target ratio for 48 hours. On CD4 T cells and CD8 T cell subsets, 818-PAT and AMX-818 increased the frequency of T cells expressing surface PD-1, where the AMX-818 curve was shifted by approximately 2.5 logs relative to 818-PAT, which indicated that Significant shadowing of the prodrug relative to its activated counterpart is indicated. The maximal activation of T cells by AMX-818(PAT) was achieved at a concentration of 625 pM, while the maximal activation of AMX-818 was achieved at a concentration of 150-600 nM.

Histograms comparing the surface levels of PD-1 on CD4 T cells and CD8 T cells at the indicated drug concentrations are shown in Figures 14A-14D .

AMX-818(PAT) and the prodrug AMX-818 induced comparable levels of CD69 and PD-1 expression on the surface of CD4+ T cells and CD8+ T cell subsets. However, the dose-response curve for AMX-818 was shifted on average >400-fold relative to that of activated AMX-818 (PAT), suggesting effective functional masking by AMX-818 ( Figure 14A and Figure 14C Data shown for CD8 T cells in ). Maximal upregulation of the activation marker CD69 and the inhibitory receptor PD-1 by AMX-818 (PAT) was observed at a concentration of 0.62 nM, whereas comparable induction of AMX-818 required concentrations of 150-600 nM ( FIGS. 14B and 14D ).

AMX-818(PAT) also potently induces the surface expression of PD-L1 on SKOV3 tumor cells, with an EC ₅₀ value of 19.7 pM, while XTEN-based AMX-818 is less potent than 650 times ( see Figures 15A-15C ). In future clinical studies, it is expected that AMX-818’s induction of PD-1 on T cells and induction of PD-L1 on target tumor cells attenuates its activity and provides the basis for PD-1 blockade therapy combined with AMX-818. principle.

AMX-818(PAT) and AMX-818 induce PD-1 to a considerable level and maximum percentage in human CD4 ⁺ T cells and CD8 ⁺ T cell subsets. However, AMX-818 was on average >400-fold less potent than AMX-818(PAT). AMX-818(PAT) potently induces PD-L1 surface expression on HER2-highly expressing SKOV3 tumor cells with an _EC50 value of 19.7 pM, whereas comparable induction by AMX-818 is >650-fold less potent. AMX-818's induction of PD-1 on T cells and induction of PD-L1 on target tumor cells is expected to attenuate their activity and provide a rationale for combining PD-1 blockade therapy with AMX-818. Example 17. XPAT was unmasked from TCE in human tumors implanted in live mice with minimal lysis observed in healthy tissue.

The present examples summarize the potent in vivo efficacy of the HER2-XPAT of the present invention. To assess antitumor activity, immunocompromised mice are injected with tumor cells expressing the target of interest. When tumors were sufficiently large and well established (over 100 ^mm3 ), human PBMCs were injected and intravenous dosing of HER2-XPAT and various control molecules began. These studies demonstrate that XPAT targeting HER2 drives tumor regression and many complete responses. AMX-818 variants without protease-cleavable linkers were inactive, indicating protease cleavage-driven activity of the linker.

In addition, HER2-XPAT expands in vivo with a safety margin. HER2 has a relatively limited expression in healthy tissue. When HER2-XPAT and its unmasked TCE counterparts were injected into NHPs, and tolerance was assessed to determine the maximum tolerated dose of each molecule. XTEN masking on XPAT significantly enhanced TCE tolerance, enabling more than 400-fold higher Cmax at MTD relative to that observed with unmasked HER2 TCE. To demonstrate that protease-cleavable linkers can be cleaved in a broad range of human tumors, XPAT cleavage was analyzed in fresh human tumor samples as well as patient-derived and xenografted tumors. In fresh human tumor explants, XPAT induces protease-cleavable linker-dependent cytokine release from tumor-resident T cells similar to that induced by a positive control (anti-CD3 antibody) of directly activated T cells intermediary hormone release.

To quantify the extent of preferential unmasking of XPAT present in tumors, XPAT cleavage in live mice was assessed. Fluorophore-labeled XPAT was injected into mice, and tumor and healthy tissues were harvested two days later to measure the levels of XPAT and cleavage products. In order to specifically quantify the lysis that occurred in live mice and to control any lysis that occurred after harvesting the tissue, we also analyzed the lysis of control XPAT added during tissue processing. In 31 mice with nine different tumor types, an average of 20% of XPAT was cleaved to the unmasked TCE form in tumors of live mice, while minimal cleavage of XPAT was observed in healthy tissue. The demonstration of limited to no lysis of control XPAT demonstrates that lysis of injected XPAT does not occur in live mice during tissue processing. The study design and data are shown in Figures 16A-C .

While preferred embodiments of the invention have been shown and described herein, it will be obvious to those skilled in the art that these embodiments are provided by way of example only. It is intended that the invention not be limited by the specific examples provided in this specification. While the invention has been described with reference to the foregoing specification, the description and illustration of the examples herein are not intended to be construed in a limiting sense. Numerous variations, changes, and substitutions will now occur to those skilled in the art without departing from the invention. Furthermore, it should be understood that all aspects of the invention are not limited to the specific depictions, configurations or relative proportions set forth herein which are subject to various conditions and variables. It should be understood that various alternatives to the embodiments of the invention described herein may be employed in practicing the invention. Accordingly, the invention should also be considered to cover any such alternatives, modifications, variations or equivalents. It is intended that the following claims define the scope of the invention and that methods and structures within the scope of these claims and their equivalents be covered thereby.

Various features of the present invention are described in detail in the appended claims. A better understanding of the features and advantages of the present invention will be obtained by reference to the following description, which sets forth illustrative examples in which the principles of the invention are utilized, and the accompanying drawings:

Figure 1 depicts a mixture of XTENylated Protease-Activating T-cell Engager ("XPAT") polypeptides with XTENs of different lengths. The full length XPAT (top) contains a 288 amino acid long XTEN at the N-terminus and an 864 amino acid long XTEN at the C-terminus. Various truncations may be present in XPAT in either or both of the N-terminal and C-terminal XTEN, for example during fermentation, purification or other steps in product preparation. While products with limited truncations (truncations near the XTEN distal end) may function in a manner similar to the full-length constructs, harsh truncations (truncations closer to the XTEN proximal end) may have their full-length counterparts. significantly different pharmacological properties. The presence of truncations poses a challenge to quantify pharmacologically effective and ineffective variants in the XPAT product. As depicted in Figure 1 using full-length XPAT, each XTEN has a proximal end and a distal end, where the proximal end is closer to a biologically active polypeptide (e.g., T cell zygote, interleukin, monoclonal antibody ( mAb), antibody fragments, or other XTENylated proteins).

Figure 2 depicts a mixture of barcoded XTEN XPAT polypeptides with different lengths. In the full-length XPAT (top), the 288 amino acid long N-terminal XTEN contains three cleavable fusion barcode sequences, namely "NA", "NB" and "NC" (from distal to proximal), And the C-terminal XTEN with a length of 864 amino acids contains three barcode sequences that can be cleaved and fused, namely "CC", "CB" and "CA" (from proximal to distal). Each barcode was positioned to indicate the pharmacologically relevant length of the corresponding XTEN. For example, a minor N-terminal truncation product of XPAT that does not have the barcode "NA" (e.g., due to truncation) but has the more proximal barcodes "NB" and "NC" can be shown to be substantially identical to the full-length construct. same pharmacological properties. In contrast, the major N-terminal truncation product of XPAT, for example, which does not have all three barcodes at the N-terminus (eg, due to truncation), is distinguishably different in pharmacological activity from the full-length construct. A unique proteolytically cleavable sequence is identified from the biologically active polypeptide of XPAT, here a tandem scFv comprising the active portion of the T cell zygote. Because a unique proteolytically cleavable sequence is present in all length variants of XPAT, including full-length XPAT, its minor truncations, and major truncations, it can be used to quantify various species relative to the total amount of biologically active protein. Reference for the amount of truncated product.

Figure 3 depicts a potential design of a barcoded XTEN utilizing the insertion of a barcode-generating sequence into a universal (or common) XTEN. An exemplary universal (or common) XTEN (top) contains a non-overlapping 12-mer motif in the sequence "BCDABDCDABDCBDCDABDCB", where sequence motifs "A", "B", "C" and "D" occur 3, 6 times, respectively , 5 and 7 times. The Glu-C protease digest of an exemplary universal XTEN (upper panel) yielded no unique peptides except for the two termini ("NT" and "CT"). Insertion of a barcode-generating sequence "X" (eg, a unique 12-mer) into the XTEN results in a unique proteolytically cleavable sequence (or barcode sequence) that does not appear anywhere else in the XTEN. The sequence "X" generating the barcode can be positioned such that the resulting barcode marks a pharmacologically relevant length of XTEN. For example, an XTEN without a barcode due to truncation may be functionally different from a corresponding XTEN with a barcode. Those of ordinary skill in the art will understand that the barcode-generating sequence ("X") can itself be a barcode sequence. Alternatively, the sequence from which the barcode is generated ("X") can be different from the resulting barcode sequence. For example, a barcode sequence may overlap with a preceding or following 12-mer motif and thus contain a portion of the 12-mer motif.

Figures 4A-4B depict quantification of the truncation level of N-terminal XTEN. Figure 4A demonstrates that a barcoded XTEN (bottom panel) can be modified by substituting a sequence motif (e.g., a third sequence motif from the N-terminus, "D") in the general XTEN (top panel) with the barcode-generating motif "X". ) to construct; and in this example, the motif ("X") generating the barcode is itself a unique proteolytically cleavable barcode sequence. As shown in the lower panel of Figure 4A, the barcodes were positioned such that all harshly truncated forms of XTEN did not have a barcode, and all limitedly truncated forms of XTEN contained a barcode. Figure 4B depicts the relative abundance of various cleavage products in two different mixtures of XPAT. In one of these mixtures, the barcode was present in 99% of the constructs containing the biologically active protein. In another of the mixtures, 13% of the constructs did not have a barcode (eg, due to truncation). Figures 4A-4B depict the use of barcoded XTENs to distinguish between two mixtures of polypeptides with substantially similar average molecular weights but with discernibly different pharmacological activities.

Figures 5A-5B and 6A-6C depict the dose dependence of masked (XTENylated) bispecific T cell engagers and unmasked bispecific T cell engagers against target cells with various levels of target antigen expression sex cytotoxicity. Proteolytically unmasked (de-XTENylated) bispecifics exhibited potent cytotoxicity against various tumor lines, for example where the EC50 was in the single digit pM range when tested with SK-OV-3 and BT-474 cells. XTENylation further exhibits robust masking capabilities, for example in preventing the formation of immune synapses by bispecific T cell engagers, thereby resulting in reduced toxicity, as indicated by a rightward shift in the concentration-response curve.

Figures 5A-5B depict efficient shielding of XTEN on XTENylated protease-activated T-cell engager ("XPAT") in general and HER2-XPAT in particular. For example, XTENylated (masked) HER2-XPAT (such as set forth in Table D) and corresponding de-XTENylated (e.g., cancer) cell lines for two different HER2 expressing (e.g., cancer) cell lines were observed in a dose-dependent manner (Unmasked, Activated) Cytotoxicity of HER2-PAT. Unmasked de-XTENylated PAT (indicated as a solid circle) produced EC50 values of 3.4 picomoles (pM) (SKOV3 cells) ( Fig. 5A ) and 4.8 pM (BT474 cells) ( Fig. 5B ), respectively, while the corresponding Shaded XTENPAT (indicated as solid squares) produced EC50 values of 44,474 pM (SKOV3 cells) and 49,370 pM (BT474 cells), indicating at least a 104 ^- fold shadowing effect.

Figure 6A depicts the efficient masking of XTEN on bispecific T cell engagers when exposed to non-cancerous tissue (cardiomyocytes). More specifically, Figure 6A shows the cytotoxicity of XTENylated (masked) HER2-XPAT (such as set forth in Table D) and corresponding de-XTENylated (unmasked, activated) HER2-PAT against cardiomyocytes. Killing of cardiomyocytes in response to T cell-directed cytolysis of unmasked de-XTENylated PAT was observed (with an EC50 concentration of approximately 64 pM) compared to tumor cells at up to 1 micromolar It is still difficult to treat with masked XTEN-PAT killing at concentrations (µM).

Figures 6B-6C depict robust masking of XTEN on bispecific T cell engagers with target cells engaging in relatively moderate or low levels of target antigen expression. For example, FIG. 6B depicts the cytotoxic effect of XTENylated and deXTENylated protease-activated T-cell engagers (PAT) on the cancer cell line MCF-7 with low levels of HER2 expression, which were masked with XTEN polypeptides to test T cell-mediated cytotoxicity of HER2-XPAT was reduced approximately 104 ^- fold. As another example, XTENylated (masked) HER2-XPAT and the corresponding deXTENylated (unmasked, activated) HER2 were assayed against another cancer cell line MDA-MB-453 with intermediate HER2 expression - Cytotoxicity of PAT ( FIG. 6C ).

Figures 7A-7D depict proteolytic activation of XTENylated bispecifics in individuals and the robust tumor regression induced thereby. Figure 7A shows that moderate molar administration in mice bearing (eg, BT-474) cleavages XTENylated HER2 T cell zygotes ("HER2-XPAT", indicated as hexagons) and corresponding untreated mice. Comparable efficacy was induced with shadowing of the HER2 T cell zygote ("HER2-PAT", indicated as a triangle). (** indicates p < 0.01). Notably, between the two tested XTENylated bispecifics, when the XTENylated construct was cleavable (indicated as hexagons) but not when the non-cleavable XTENylated counterpart (indicated as diamonds) Tumor regression was observed, indicating that proteolytic unmasking (de-XTENylation) is a prerequisite for efficacy. Figure 7B depicts the efficacy of a cleavable XTENylated bispecific (eg, HER2-XPAT) against large tumors at a single dose (eg, 2.1 mg/kg (mpk)). The non-cleavable constructs used in the experiments were the same as the corresponding cleavable constructs, but the release sites had been replaced by GASTEP amino acids (glycine, alanine, serine, threonine, glutamic acid and/or Proline) produced non-cleavable sequence substitutions of similar length. Figure 7C shows the ratio of masked HER2-PAT (solid triangles) at two different concentrations (15 nmol/Kg and 36 nmol/Kg) compared to unmasked HER2-PAT (solid squares) and non-cleavable XPAT (solid diamonds). effect. Data for vehicle and vehicle+PBMC treated tumors are also shown. Figure 7D shows the percentage of HER2-PAT cleavage in vivo in BT-474 tumor bearing mice.

Figure 8 depicts lymphocyte margination induced by administration of XTENylated HER2-XPAT in individuals. For example, following a single dose of XTENylated HER2-XPAT (eg, as set forth in Table D) intravenous infusion (eg, 25 mg/kg at a dose volume of 10 ml/kg), in female and male monkey subjects Decreased lymphocyte counts (blood disease) were observed in both (as indicated by triangles and squares, respectively), beginning 6 hours post-dose and continuing until at least 24-72 hours post-dose.

Figures 9A-9B . Figure 9A depicts the stability of circulating XTENylated protease-activated T cell engagers (PAT) in plasma (eg, at a dose of 25 mg/kg) in individuals (eg, cynomolgus monkeys). The lack of significant increase in clearance of XTENPAT relative to the non-cleavable form of XTENPAT indicates minimal cleavage in the periphery. Comparable pharmacokinetics were observed between the cleavable HER2-XPAT tested (solid triangles and solid squares) and the non-cleavable counterparts (unfilled triangles and unfilled squares). The non-cleavable constructs used in the experiments were the same as the corresponding cleavable constructs, but the release sites had been replaced by GASTEP amino acids (glycine, alanine, serine, threonine, glutamic acid and/or Proline) produced non-cleavable sequence substitutions of similar length. Figure 9B shows that there is still a low frequency of HER2-XPAT proteolytic metabolites in circulation even 96 hours after administration.

Figures 10A-10C . Figure 10A shows a single dose of single subject HER2-XPAT dose escalation and demonstrated tolerance to all doses up to 42 mg/kg. FIG. 10B shows a schematic diagram of HER2-PAT decline in a single individual, where the maximum tolerated dose of unmasked HER2-PAT is 0.2 mg/kg. Figure 10C shows plasma concentrations of shielded HER2-PAT (at a 450-fold higher tolerated Cmax) compared to unshielded HER2-PAT.

Figures 11A-11E . Figures 1 IA and 1 IB show peripheral T cell activation data showing the absence of peripheral T cell activation in response to HER2-XPAT compared to HER2-PAT. Figures 11C-11E show the levels of interleukin IL-6 ( Figure 11C ), TNF-α ( Figure 11D ) and IFN-γ ( Figure 11E ) in individuals treated with different concentrations of HER2-XPAT and HER2-PAT, indicating that Even HER2-XPAT at 50 mg/kg did not induce cytokine release. Note that the normal range of interleukin content: IL-6 ≤ 6 pg/ml, TNFα 1-10 pg/ml, IFNγ ≤ 10 pg/ml.

Figure 12. AMX-818 grown ex vivo in plasma samples from NHP and humans shows minimal cleavage to unmasked TCE, even under inflammatory conditions. AMX-818 with a fluorescent label (DyL650) attached to the tandem scFv was incubated in the indicated plasma samples for seven days at 37°C. Subsequently, samples were run on a gel and metabolites similar in size to the unmasked active form of AMX-818 were quantified using a LI-COR detector. Inflammatory diseases Human samples were derived from patients with rheumatoid arthritis, lupus, inflammatory bowel disease and multiple sclerosis. Cancer human samples were derived from patients with lung, breast and colon tumors. Sample size: healthy NHP N=4, healthy human N=4, "inflamed" NHP N=6, "inflamed" human N=27, cancer human N=11.

Figures 13A- 13B. Provide additional information supporting the safety profile of the preferred HER2- XPAT of the present invention. The data in Figure 13A show comparable PK between HER2-XPAT and non-cleavable HER2-PAT forms, suggesting that even at high doses, the protease release site remains largely stable in cynomolgus monkey circulation. Figure 13B shows that even at high doses of HER2 XPAT there is very limited systemic accumulation of metabolites not masked by one or two XTENs.

Figures 14A-14D. AMX818 and 818-PAT induce surface PD-1 expression on T cells in response to SKOV3 tumor cells. Surface PD-1 expression on CD4+ T cells and CD8+ T cells was assessed by flow cytometry after PBMC and SKOV3 cells were co-incubated at a 5:1 effector:target ratio for 48 hours with the indicated concentrations of test substances. Figures 14A and 14C show surface PD1 expression on CD4+ T cells in the presence of AMX818 and 818-PAT. Figures 14B and 14D show surface PDl expression on CD8+ T cells in the presence of AMX818 and 818-PAT.

Figures 13A-13C . AMX818 and 818-PAT induce surface PD-L1 expression on T cells in response to SKOV3 tumor cells. Figures 15A and 15B show PD-L1 expression on SKOV3 cells at a 5:1 effector:target ratio with the indicated concentrations of test articles. Figure 15C shows surface HER2 expression on SKOV3 tumor cells.

Figures 16A-16C. XPAT is preferentially cleaved to unmasked TCE in human tumors implanted in live mice, with minimal cleavage observed in healthy tissue. A single dose of 1.8 mg/kg (13 nM) of XPAT labeled with a red fluorophore (Alexa) was injected into mice implanted with human tumors ( FIG. 16A ). Two days later, tumors and healthy organs were harvested to measure protease cleavage in vivo (results are shown in Figure 16B ). Green fluorophore-labeled (Dyl800) XPAT was added after harvesting the tissue in the presence of protease inhibitors to account for artificial lysis that may be caused by the release of unrelated intracellular proteases during processing. By comparing the cleavage products generated for both red fluorophore-labeled XPAT and green fluorophore-labeled XPAT, we were able to determine the cleavage that occurs in various tissues in vivo versus artificially during tissue processing. By day 2 after injection into tumor-implanted mice, an average of 20% of XPAT was activated in tumors (n=31 in 9 tumor types; FIG. 16C ).

The patent or application file contains at least one drawing in color. Copies of this patent or patent application publication with color drawing(s) will be provided by the Office upon request and payment of the necessary fee.

         
           <![CDATA[ <110> Amunix Pharmaceuticals Inc.]]>
           <![CDATA[ <120> Bispecific composition targeting HER-2 and methods for its manufacture and use]]>
           <![CDATA[ <130> 20-1832-WO]]>
           <![CDATA[ <150> 63/196408]]>
           <![CDATA[ <151> 2021-06-03]]>
           <![CDATA[ <150> 63/166857]]>
           <![CDATA[ <151> 2021-03-26]]>
           <![CDATA[ <160> 8022 ]]>
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           <![CDATA[ <400> 12]]> Ala Ser Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Ser Gly Thr Ser 1 5 10 15 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 20 25 30 Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 35 40 45 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 50 55 60 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Thr Pro Ala Glu Ser 65 70 75 80 Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 85 90 95 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro 100 105 110 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr 115 120 125 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 130 135 140 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro 145 150 155 160 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro 165 170 175 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 180 185 190 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 195 200 205 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr 210 215 220 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 225 230 235 240 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro 245 250 255 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser 260 265 270 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Ser Ala 275 280 285 Pro Gly Gly Ser Ala Pro Leu Gly Gly Arg Ala Asp Asn His Glu Pro 290 295 300 Pro Glu Leu Gly Ala Gly Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 305 310 315 320 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 325 330 335 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 340 345 350 Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 355 360 365 Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 370 375 380 Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Leu Gln Pro 385 390 395 400 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 405 410 415 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Ala Thr Pro Pro 420 425 430 Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly Glu Thr Thr Gly Gly Ser 435 440 445 Ala Glu Ser Glu Pro Pro Gly Glu Gly Glu Val Gln Leu Val Glu Ser 450 455 460 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 465 470 475 480 Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln 485 490 495 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn 500 505 510 Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 515 520 525 Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg 530 535 540 Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly 545 550 555 560 Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 565 570 575 Ser Gly Gly Gly Ser Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr 580 585 590 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly 595 600 605 Ala Val Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly 610 615 620 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly 625 630 635 640 Thr Pro Ala Arg Phe Ser Gly Ser Ser Leu Gly Gly Ser Ala Ala Leu 645 650 655 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala 660 665 670 Leu Trp Tyr Ser Asn Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 675 680 685 Val Leu Gly Ala Thr Pro Pro Glu Thr Gly Ala Glu Thr Glu Ser Pro 690 695 700 Gly Glu Thr Thr Gly Gly Ser Ala Glu Ser Glu Pro Pro Gly Glu Gly 705 710 715 720 Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 725 730 735 Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 74 0 745 750 Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 755 760 765 Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 770 775 780 Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 785 790 795 800 Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 805 810 815 Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 823 0 Ala 8 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Thr Ala 835 840 845 Glu Ala Ala Ser Ala Ser Gly Leu Gly Arg Ala Asp Asn His Glu 850 855 860 Pro Pro Glu Leu Gly Ala Gly Ser Ala Gly Ser Pro Gly Ser Pro Ala 865 870 875 880 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Al a Thr Pro 885 890 895 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 900 905 910 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr 915 920 925 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 930 935 940 Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 945 950 955 960 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro 965 970 975 Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr 980 985 990 Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 995 1000 1005 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 1010 1015 1020 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser 1025 1030 1035 Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Se r Glu Gly 1040 1045 1050 Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 1055 1060 1065 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 1070 1075 1080 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala 1085 1090 1095 Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 1100 1105 1110 Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 1115 1120 1125 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 1130 1135 1140 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala 1145 1150 1155 Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 1160 1165 1170 Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 1175 1180 1185 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 1190 1195 1200 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro 1205 1210 1215 Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 1220 1225 1230 Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 1235 1240 1245 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 1250 1255 1260 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro 1265 1270 1275 Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 1280 1285 1290 Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 1295 1300 1305 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu 1310 1315 1320 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala 1325 1330 1335 Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 1340 1345 1350 Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 1355 1360 1365 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 1370 1375 1380 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser 1385 1390 1395 Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser 1400 1405 1410 Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 1415 1420 1425 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 1430 1435 1440 Thr Glu Pro Ser Glu Gly S er Ala Pro Gly Thr Ser Glu Ser Ala 1445 1450 1455 Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 1460 1465 1470 Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 1475 1480 1485 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 1490 1495 1500 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro 1505 1510 1515 Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 1520 1525 1530 Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 1535 1540 1545 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 1550 1555 1560 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser 1565 1570 1575 Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser 1580 1585 1590 Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 1595 1600 1605 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 1610 1615 1620 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala 1625 1630 1635 Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Se r Gly Ser 1640 1645 1650 Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 1655 1660 1665 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 1670 1675 1680 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro 1685 1690 1695 Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 1700 1705 1710 Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 1715 1720 1725 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro 1730 1735 1740 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala 1745 1750 1755 Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 1760 1765 1770 Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 1775 1780 1785 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 1790 1795 1800 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala 1805 1810 1815 Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 1820 1825 1830 Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Thr Glu Thr 1835 1840 1845 Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr 1850 1855 1860 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu 1865 1870 1875 Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 1880 1885 1890 Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 1895 1900 1905 Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr 1910 1915 1920 Ala Thr Glu Ser Pro Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser 1925 1930 1935 Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 1940 1945 1950 Gly Ser Ala Pro Gly Thr Ser Ala Glu Ser Ala Thr Pro Glu Ser 1955 1960 1965 Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 1970 1975 1980 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 1985 1990 1995 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 2000 2005 2010 Pro Glu Ser Gly Pro Gly Thr Glu Ser Ala Ser 2015 2020 <![CDATA[ <210> 13]]>
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          Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  35 40 45
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
              50 55 60
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Thr Pro Ala Glu Ser
          65 70 75 80
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                          85 90 95
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro
                      100 105 110
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
                  115 120 125
          Pro Glu Ser Gly Pro Gly Glu Glu Pro Ala Thr Ser Gly Ser Thr Pro
              130 135 140
          Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro
          145 150 155 160
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro
                          165 170 175
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
                      180 185 190
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                  195 200 205
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr
              210 215 220
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
          225 230 235 240
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro
                          245 250 255
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser
                      260 265 270
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                  275 280 285
          Pro Gly Gly Ser Ala Pro Ala Ser Thr Arg Gly Glu Asn Ala Gly Pro
              290 295 300
          Ala Gly Leu Glu Ala Pro Ala Thr Ser Ser Gly Ser Glu Thr Pro Gly Thr
          305 310 315 320
          Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
                          325 330 335
          Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ile Gly
                      340 345 350
          Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
                  355 360 365
          Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly
              370 375 380
          Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
          385 390 395 400
          Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ile Tyr Pro Tyr
                          405 410 415
          Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Ala Thr Pro Pro
                      420 425 430
          Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly Glu Thr Thr Gly Gly Ser
                  435 440 445
          Ala Glu Ser Glu Pro Pro Gly Glu Gly Glu Val Gln Leu Val Glu Ser
              450 455 460
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala
          465 470 475 480
          Ala Ser Gly Phe Thr Phe Thr Asp Tyr Thr Met Asp Trp Val Arg Gln
                          485 490 495
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Asp Val Asn Pro Asn Ser
                      500 505 510
          Gly Gly Ser Ile Tyr Asn Gln Arg Phe Lys Gly Arg Phe Thr Leu Ser
                  515 520 525
          Val Asp Arg Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg
              530 535 540
          Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn Leu Gly Pro Ser
          545 550 555 560
          Phe Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                          565 570 575
          Gly Gly Gly Ser Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val
                      580 585 590
          Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser Ser Asn Gly Ala
                  595 600 605
          Val Thr Ser Ser Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln
              610 615 620
          Ala Pro Arg Gly Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr
          625 630 635 640
          Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr
                          645 650 655
          Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Val Tyr Tyr Cys Ala Leu
                      660 665 670
          Trp Tyr Pro Asn Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val
                  675 680 685
          Leu Gly Ala Thr Pro Pro Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly
              690 695 700
          Glu Thr Thr Gly Gly Ser Ala Glu Ser Glu Pro Pro Gly Glu Gly Glu
          705 710 715 720
          Val Gln Leu Leu Glu Ser Gly Gly Gly Ile Val Gln Pro Gly Gly Ser
                          725 730 735
          Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr Ala
                      740 745 750
          Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala
                  755 760 765
          Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser
              770 775 780
          Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Val
          785 790 795 800
          Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr
                          805 810 815
          Cys Val Arg His Glu Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala
                      820 825 830
          His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Thr Ala Glu
                  835 840 845
          Ala Ala Ser Ala Ser Gly Ala Ser Thr Arg Gly Glu Asn Ala Gly Pro
              850 855 860
          Ala Gly Leu Glu Ala Pro Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser
          865 870 875 880
          Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly
                          885 890 895
          Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser
                      900 905 910
          Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly
                  915 920 925
          Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
              930 935 940
          Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu
          945 950 955 960
          Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly
                          965 970 975
          Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
                      980 985 990
          Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu
                  995 1000 1005
          Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro
              1010 1015 1020
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
              1025 1030 1035
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser
              1040 1045 1050
          Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser
              1055 1060 1065
          Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu
              1070 1075 1080
          Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
              1085 1090 1095
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser
              1100 1105 1110
          Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly
              1115 1120 1125
          Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro
              1130 1135 1140
          Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
              1145 1150 1155
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser
              1160 1165 1170
          Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser
              1175 1180 1185
          Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly
              1190 1195 1200
          Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
              1205 1210 1215
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser
              1220 1225 1230
          Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser
              1235 1240 1245
          Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly
              1250 1255 1260
          Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
              1265 1270 1275
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser
              1280 1285 1290
          Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu
              1295 1300 1305
          Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro
              1310 1315 1320
          Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
              1325 1330 1335
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser
              1340 1345 1350
          Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala
              1355 1360 1365
          Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr
              1370 1375 1380
          Ser Thr Glu Glu Gly Thr Ser Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
              1385 1390 1395
          Pro Gly Thr Glu Ser Thr Pro Ser Glu Gly Ser Ala Pro Gly Ser
              1400 1405 1410
          Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser
              1415 1420 1425
          Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu
              1430 1435 1440
          Gly Ser Ala Pro Gly Glu Pro Glu Ala
              1445 1450
           <![CDATA[ <210> 14]]>
           <![CDATA[ <211> 1446]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 14]]>
          Ala Ser Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Ser Gly Thr Ser
          1 5 10 15
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Glu Thr Glu Pro Ser
                      20 25 30
          Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  35 40 45
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
              50 55 60
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Thr Pro Ala Glu Ser
          65 70 75 80
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                          85 90 95
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro
                      100 105 110
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
                  115 120 125
          Pro Glu Ser Gly Pro Gly Glu Ser Pro Ala Thr Ser Gly Ser Thr Pro
              130 135 140
          Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro
          145 150 155 160
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro
                          165 170 175
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
                      180 185 190
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                  195 200 205
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr
              210 215 220
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
          225 230 235 240
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro
                          245 250 255
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser
                      260 265 270
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                  275 280 285
          Pro Gly Gly Ser Ala Pro Glu Ala Gly Arg Ser Ala Asn His Thr Pro
              290 295 300
          Ala Gly Leu Thr Gly Pro Ala Thr Ser Ser Gly Ser Glu Thr Pro Gly Thr
          305 310 315 320
          Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
                          325 330 335
          Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Asp Val Ser Ile Gly
                      340 345 350
          Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
                  355 360 365
          Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ala Arg Phe Ser Gly
              370 375 380
          Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
          385 390 395 400
          Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Ile Tyr Pro Tyr
                          405 410 415
          Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Ala Thr Pro Pro
                      420 425 430
          Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly Glu Thr Thr Gly Gly Ser
                  435 440 445
          Ala Glu Ser Glu Pro Pro Gly Glu Gly Gln Val Gln Leu Val Gln Ser
              450 455 460
          Gly Val Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys
          465 470 475 480
          Ala Ser Gly Phe Thr Phe Thr Asp Tyr Thr Met Asp Trp Val Arg Gln
                          485 490 495
          Ala Pro Gly Gln Gly Leu Glu Trp Met Ala Asp Val Asn Pro Asn Ser
                      500 505 510
          Gly Gly Ser Ile Tyr Asn Gln Arg Phe Lys Gly Arg Val Thr Leu Thr
                  515 520 525
          Thr Asp Ser Ser Thr Thr Thr Ala Tyr Met Glu Leu Lys Ser Leu Gln
              530 535 540
          Phe Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn Leu Gly Pro Ser
          545 550 555 560
          Phe Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                          565 570 575
          Gly Gly Gly Ser Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val
                      580 585 590
          Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser Ser Asn Gly Ala
                  595 600 605
          Val Thr Ser Ser Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln
              610 615 620
          Ala Pro Arg Gly Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr
          625 630 635 640
          Pro Ala Arg Phe Ser Gly Ser Ser Leu Gly Gly Lys Ala Ala Leu Thr
                          645 650 655
          Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Val Tyr Tyr Cys Ala Leu
                      660 665 670
          Trp Tyr Pro Asn Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val
                  675 680 685
          Leu Gly Ala Thr Pro Pro Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly
              690 695 700
          Glu Thr Thr Gly Gly Ser Ala Glu Ser Glu Pro Pro Gly Glu Gly Glu
          705 710 715 720
          Val Gln Leu Gln Glu Ser Gly Gly Gly Ile Val Gln Pro Gly Gly Ser
                          725 730 735
          Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr Ala
                      740 745 750
          Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala
                  755 760 765
          Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser
              770 775 780
          Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Val
          785 790 795 800
          Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr
                          805 810 815
          Cys Val Arg His Glu Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala
                      820 825 830
          His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Thr Ala Glu
                  835 840 845
          Ala Ala Ser Ala Ser Gly Glu Ala Gly Arg Ser Ala Asn His Thr Pro
              850 855 860
          Ala Gly Leu Thr Gly Pro Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu
          865 870 875 880
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr
                          885 890 895
          Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                      900 905 910
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu
                  915 920 925
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu
              930 935 940
          Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
          945 950 955 960
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Ser Thr
                          965 970 975
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu
                      980 985 990
          Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
                  995 1000 1005
          Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
              1010 1015 1020
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala
              1025 1030 1035
          Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser
              1040 1045 1050
          Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
              1055 1060 1065
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
              1070 1075 1080
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro
              1085 1090 1095
          Ser Glu Gly Ser Ala Pro Gly Thr Ser Ser Glu Ser Ala Thr Pro Glu
              1100 1105 1110
          Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
              1115 1120 1125
          Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro
              1130 1135 1140
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala
              1145 1150 1155
          Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly
              1160 1165 1170
          Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
              1175 1180 1185
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
              1190 1195 1200
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr
              1205 1210 1215
          Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr Pro Glu
              1220 1225 1230
          Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
              1235 1240 1245
          Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
              1250 1255 1260
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr
              1265 1270 1275
          Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr Pro Glu
              1280 1285 1290
          Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
              1295 1300 1305
          Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
              1310 1315 1320
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala
              1325 1330 1335
          Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu
              1340 1345 1350
          Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
              1355 1360 1365
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu
              1370 1375 1380
          Ser Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser
              1385 1390 1395
          Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly
              1400 1405 1410
          Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
              1415 1420 1425
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
              1430 1435 1440
          Glu Ser Ala
              1445
           <![CDATA[ <210> 15]]>
           <![CDATA[ <211> 1447]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 15]]>
          Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Ser Gly Thr Ser Glu Ser
          1 5 10 15
          Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly
                      20 25 30
          Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly
                  35 40 45
          Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser
              50 55 60
          Ala Thr Pro Glu Ser Gly Pro Gly Ser Thr Pro Ala Glu Ser Gly Ser
          65 70 75 80
          Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly
                          85 90 95
          Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly
                      100 105 110
          Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu
                  115 120 125
          Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
              130 135 140
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly
          145 150 155 160
          Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser
                          165 170 175
          Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
                      180 185 190
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser
                  195 200 205
          Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu
              210 215 220
          Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
          225 230 235 240
          Ser Glu Pro Ala Thr Ser Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly
                          245 250 255
          Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Thr Glu Gly
                      260 265 270
          Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
                  275 280 285
          Gly Ser Ala Pro Leu Phe Gly Arg Asn Asp Asn His Glu Pro Leu Glu
              290 295 300
          Leu Gly Gly Gly Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Asp Ile
          305 310 315 320
          Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg
                          325 330 335
          Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala
                      340 345 350
          Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser
                  355 360 365
          Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg
              370 375 380
          Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp
          385 390 395 400
          Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe
                          405 410 415
          Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Ala Thr Pro Pro Glu Thr
                      420 425 430
          Gly Ala Glu Thr Glu Ser Pro Gly Glu Thr Thr Thr Gly Gly Ser Ala Glu
                  435 440 445
          Ser Glu Pro Pro Gly Glu Gly Glu Val Gln Leu Val Glu Ser Gly Gly
              450 455 460
          Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser
          465 470 475 480
          Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro
                          485 490 495
          Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr
                      500 505 510
          Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp
                  515 520 525
          Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu
              530 535 540
          Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr
          545 550 555 560
          Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly
                          565 570 575
          Gly Gly Ser Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser
                      580 585 590
          Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val
                  595 600 605
          Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala
              610 615 620
          Pro Arg Gly Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro
          625 630 635 640
          Ala Arg Phe Ser Gly Ser Ser Leu Gly Gly Ser Ala Ala Leu Thr Leu
                          645 650 655
          Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp
                      660 665 670
          Tyr Ser Asn Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
                  675 680 685
          Gly Ala Thr Pro Pro Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly Glu
              690 695 700
          Thr Thr Gly Gly Ser Ala Glu Ser Glu Pro Pro Gly Glu Gly Glu Val
          705 710 715 720
          Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu
                          725 730 735
          Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr Ala Met
                      740 745 750
          Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg
                  755 760 765
          Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val
              770 775 780
          Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr
          785 790 795 800
          Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys
                          805 810 815
          Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr
                      820 825 830
          Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Thr Ala Glu Ala
                  835 840 845
          Ala Ser Ala Ser Gly Leu Phe Gly Arg Asn Asp Asn His Glu Pro Leu
              850 855 860
          Glu Leu Gly Gly Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr
          865 870 875 880
          Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser
                          885 890 895
          Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala
                      900 905 910
          Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser
                  915 920 925
          Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr
              930 935 940
          Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro
          945 950 955 960
          Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser
                          965 970 975
          Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser
                      980 985 990
          Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro
                  995 1000 1005
          Ser Glu Gly Ser Ala Pro Gly Thr Ser Ser Glu Ser Ala Thr Pro Glu
              1010 1015 1020
          Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro
              1025 1030 1035
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu
              1040 1045 1050
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala
              1055 1060 1065
          Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly
              1070 1075 1080
          Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
              1085 1090 1095
          Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro
              1100 1105 1110
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser
              1115 1120 1125
          Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu
              1130 1135 1140
          Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
              1145 1150 1155
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu
              1160 1165 1170
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala
              1175 1180 1185
          Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser
              1190 1195 1200
          Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
              1205 1210 1215
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro
              1220 1225 1230
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala
              1235 1240 1245
          Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser
              1250 1255 1260
          Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
              1265 1270 1275
          Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro
              1280 1285 1290
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro
              1295 1300 1305
          Ser Glu Gly Ser Ala Pro Gly Thr Ser Ser Glu Ser Ala Thr Pro Glu
              1310 1315 1320
          Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
              1325 1330 1335
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu
              1340 1345 1350
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr
              1355 1360 1365
          Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser
              1370 1375 1380
          Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
              1385 1390 1395
          Gly Thr Glu Ser Thr Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu
              1400 1405 1410
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala
              1415 1420 1425
          Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly
              1430 1435 1440
          Ser Ala Pro Gly
              1445
           <![CDATA[ <210> 16]]>
           <![CDATA[ <211> 1452]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 16]]>
          Ala Ser Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Ser Gly Thr Ser
          1 5 10 15
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
                      20 25 30
          Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  35 40 45
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
              50 55 60
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Thr Pro Ala Glu Ser
          65 70 75 80
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                          85 90 95
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro
                      100 105 110
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
                  115 120 125
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
              130 135 140
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro
          145 150 155 160
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro
                          165 170 175
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
                      180 185 190
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                  195 200 205
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr
              210 215 220
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
          225 230 235 240
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro
                          245 250 255
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser
                      260 265 270
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                  275 280 285
          Pro Gly Gly Ser Ala Pro Arg Thr Gly Arg Thr Gly Glu Ser Ala Asn
              290 295 300
          Glu Thr Pro Ala Gly Leu Gly Gly Pro Ala Thr Ser Gly Ser Glu Thr
          305 310 315 320
          Pro Gly Thr Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu
                          325 330 335
          Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Asp Val
                      340 345 350
          Ser Ile Gly Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg
                  355 360 365
          Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ala Arg
              370 375 380
          Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser
          385 390 395 400
          Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Ile
                          405 410 415
          Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Ala
                      420 425 430
          Thr Pro Pro Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly Glu Thr Thr
                  435 440 445
          Gly Gly Ser Ala Glu Ser Glu Pro Pro Gly Glu Gly Gln Val Gln Leu
              450 455 460
          Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val
          465 470 475 480
          Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Asp Tyr Thr Met Asp Trp
                          485 490 495
          Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Ala Asp Val Asn
                      500 505 510
          Pro Asn Ser Gly Gly Ser Ile Tyr Asn Gln Arg Phe Lys Gly Arg Val
                  515 520 525
          Thr Leu Thr Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr Met Glu Leu Lys
              530 535 540
          Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn Leu
          545 550 555 560
          Gly Pro Ser Phe Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr
                          565 570 575
          Val Ser Ser Gly Gly Gly Ser Glu Leu Val Val Thr Gln Glu Pro Ser
                      580 585 590
          Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser Ser
                  595 600 605
          Asn Gly Ala Val Thr Ser Ser Asn Tyr Ala Asn Trp Val Gln Gln Lys
              610 615 620
          Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Asn Lys Arg Ala
          625 630 635 640
          Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala
                          645 650 655
          Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Val Tyr Tyr
                      660 665 670
          Cys Ala Leu Trp Tyr Pro Asn Leu Trp Val Phe Gly Gly Gly Thr Lys
                  675 680 685
          Leu Thr Val Leu Gly Ala Thr Pro Pro Glu Thr Gly Ala Glu Thr Glu
              690 695 700
          Ser Pro Gly Glu Thr Thr Gly Gly Ser Ala Glu Ser Glu Pro Pro Gly
          705 710 715 720
          Glu Gly Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Ile Val Gln Pro
                          725 730 735
          Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn
                      740 745 750
          Thr Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu
                  755 760 765
          Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr
              770 775 780
          Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys
          785 790 795 800
          Asn Thr Val Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala
                          805 810 815
          Val Tyr Tyr Cys Val Arg His Glu Asn Phe Gly Asn Ser Tyr Val Ser
                      820 825 830
          Trp Phe Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly
                  835 840 845
          Thr Ala Glu Ala Ala Ser Ala Ser Gly Arg Thr Gly Arg Thr Gly Glu
              850 855 860
          Ser Ala Asn Glu Thr Pro Ala Gly Leu Gly Gly Pro Gly Ser Glu Thr
          865 870 875 880
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
                          885 890 895
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
                      900 905 910
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                  915 920 925
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
              930 935 940
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser
          945 950 955 960
          Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                          965 970 975
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                      980 985 990
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
                  995 1000 1005
          Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser
              1010 1015 1020
          Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
              1025 1030 1035
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu
              1040 1045 1050
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro
              1055 1060 1065
          Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser
              1070 1075 1080
          Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
              1085 1090 1095
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr
              1100 1105 1110
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser
              1115 1120 1125
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser
              1130 1135 1140
          Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
              1145 1150 1155
          Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr
              1160 1165 1170
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro
              1175 1180 1185
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser
              1190 1195 1200
          Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly
              1205 1210 1215
          Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu
              1220 1225 1230
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
              1235 1240 1245
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser
              1250 1255 1260
          Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
              1265 1270 1275
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala
              1280 1285 1290
          Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro
              1295 1300 1305
          Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr
              1310 1315 1320
          Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly
              1325 1330 1335
          Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu
              1340 1345 1350
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
              1355 1360 1365
          Gly Ser Thr Glu Thr Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser
              1370 1375 1380
          Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
              1385 1390 1395
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr
              1400 1405 1410
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro
              1415 1420 1425
          Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser
              1430 1435 1440
          Gly Pro Gly Ser Glu Pro Ala Thr Ser
              1445 1450
           <![CDATA[ <210> 17]]>
           <![CDATA[ <211> 1446]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 17]]>
          Ala Ser Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Ser Gly Thr Ser
          1 5 10 15
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
                      20 25 30
          Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  35 40 45
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
              50 55 60
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Thr Pro Ala Glu Ser
          65 70 75 80
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                          85 90 95
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro
                      100 105 110
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
                  115 120 125
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
              130 135 140
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro
          145 150 155 160
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro
                          165 170 175
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
                      180 185 190
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                  195 200 205
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr
              210 215 220
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
          225 230 235 240
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro
                          245 250 255
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser
                      260 265 270
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                  275 280 285
          Pro Gly Gly Ser Ala Pro Gly Ala Gly Arg Thr Asp Asn His Glu Pro
              290 295 300
          Leu Glu Leu Gly Ala Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
          305 310 315 320
          Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
                          325 330 335
          Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ile Gly
                      340 345 350
          Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
                  355 360 365
          Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly
              370 375 380
          Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
          385 390 395 400
          Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ile Tyr Pro Tyr
                          405 410 415
          Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Ala Thr Pro Pro
                      420 425 430
          Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly Glu Thr Thr Gly Gly Ser
                  435 440 445
          Ala Glu Ser Glu Pro Pro Gly Glu Gly Glu Val Gln Leu Val Glu Ser
              450 455 460
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala
          465 470 475 480
          Ala Ser Gly Phe Thr Phe Thr Asp Tyr Thr Met Asp Trp Val Arg Gln
                          485 490 495
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Asp Val Asn Pro Asn Ser
                      500 505 510
          Gly Gly Ser Ile Tyr Asn Gln Arg Phe Lys Gly Arg Phe Thr Leu Ser
                  515 520 525
          Val Asp Arg Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg
              530 535 540
          Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn Leu Gly Pro Ser
          545 550 555 560
          Phe Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                          565 570 575
          Gly Gly Gly Ser Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val
                      580 585 590
          Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala
                  595 600 605
          Val Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln
              610 615 620
          Ala Pro Arg Gly Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr
          625 630 635 640
          Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr
                          645 650 655
          Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu
                      660 665 670
          Trp Tyr Ser Asn Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val
                  675 680 685
          Leu Gly Ala Thr Pro Pro Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly
              690 695 700
          Glu Thr Thr Gly Gly Ser Ala Glu Ser Glu Pro Pro Gly Glu Gly Glu
          705 710 715 720
          Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser
                          725 730 735
          Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr Ala
                      740 745 750
          Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala
                  755 760 765
          Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser
              770 775 780
          Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala
          785 790 795 800
          Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr
                          805 810 815
          Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala
                      820 825 830
          Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Thr Ala Glu
                  835 840 845
          Ala Ala Ser Ala Ser Gly Gly Ala Gly Arg Thr Asp Asn His Glu Pro
              850 855 860
          Leu Glu Leu Gly Ala Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu
          865 870 875 880
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr
                          885 890 895
          Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                      900 905 910
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu
                  915 920 925
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu
              930 935 940
          Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
          945 950 955 960
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Ser Thr
                          965 970 975
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu
                      980 985 990
          Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
                  995 1000 1005
          Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
              1010 1015 1020
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala
              1025 1030 1035
          Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser
              1040 1045 1050
          Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
              1055 1060 1065
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
              1070 1075 1080
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro
              1085 1090 1095
          Ser Glu Gly Ser Ala Pro Gly Thr Ser Ser Glu Ser Ala Thr Pro Glu
              1100 1105 1110
          Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
              1115 1120 1125
          Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro
              1130 1135 1140
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala
              1145 1150 1155
          Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly
              1160 1165 1170
          Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
              1175 1180 1185
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
              1190 1195 1200
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr
              1205 1210 1215
          Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr Pro Glu
              1220 1225 1230
          Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
              1235 1240 1245
          Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
              1250 1255 1260
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr
              1265 1270 1275
          Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr Pro Glu
              1280 1285 1290
          Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
              1295 1300 1305
          Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
              1310 1315 1320
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala
              1325 1330 1335
          Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu
              1340 1345 1350
          Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
              1355 1360 1365
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu
              1370 1375 1380
          Ser Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser
              1385 1390 1395
          Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly
              1400 1405 1410
          Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
              1415 1420 1425
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
              1430 1435 1440
          Glu Ser Ala
              1445
           <![CDATA[ <210> 18]]>
           <![CDATA[ <211> 2307]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 18]]> Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 1 5 10 15 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 20 25 30 Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 35 40 45 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 50 55 60 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 65 70 75 80 Glu Ser Gly Pro Gly Ser Glu Ser Ala Thr Ser Gly Ser Glu Thr Pro 85 90 95 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala 100 105 110 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 115 120 125 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Ser Ala Pro 130 135 140 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala 145 150 155 160 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu 165 170 175 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 180 185 190 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 195 200 205 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 210 215 220 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 225 230 235 240 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 245 250 255 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 260 265 270 Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 275 280 285 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 290 295 300 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 305 310 315 320 Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 325 330 335 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 340 345 350 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 355 360 365 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 370 375 380 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 385 390 395 400 Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 405 410 415 Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 420 425 430 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 435 440 445 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 450 455 460 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 465 470 475 480 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 485 490 495 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 500 505 510 Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 515 520 525 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala 530 535 540 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 545 550 555 560 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 565 570 575 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 580 585 590 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 595 600 605 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 610 615 620 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 625 630 635 640 Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 645 650 655 Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 660 665 670 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu 675 680 685 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr 690 695 700 Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Thr Glu Glu 705 710 715 720 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 725 730 735 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro 74 0 745 750 Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 755 760 765 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro 770 775 780 Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr 785 790 795 800 Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 805 810 815 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro 820 825 830 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 835 840 845 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 850 855 860 Glu Ser Gly Arg Ala Ala Asn Thr Gly Pro Pro Thr Leu Thr Ala Pro 865 870 875 880 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Asp Ile Gln Me t Thr Gln 885 890 895 Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 900 905 910 Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln 915 920 925 Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu 930 935 940 Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp 945 950 955 960 Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 965 970 975 Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr 980 985 990 Lys Val Glu Ile Lys Gly Ala Thr Pro Pro Glu Thr Gly Ala Glu Thr 995 1000 1005 Glu Ser Pro Gly Glu Thr Thr Gly Gly Ser Ala Glu Ser Glu Pro 1010 1015 1020 Pro Gly Glu Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 1025 1030 1035 Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Al a Ser Gly 1040 1045 1050 Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro 1055 1060 1065 Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly 1070 1075 1080 Tyr Val Thr Asp Tyr Ala Lys Gly Arg Phe Thr Ile Ser 1085 1090 1095 Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu 1100 1105 1110 Arg Ala Glu Asp Thr Ala Val Tyr Cys Ser Arg Trp Gly Gly 1115 1120 Gly Phe 1125 Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 1130 1135 1140 Thr Val Ser Ser Gly Gly Gly Ser Glu Leu Val Val Thr Gln Glu 1145 1150 1155 Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys 1160 1165 1 Arg Ser Ser Asn Gly Ala Val Thr Ser Ser Asn Tyr Ala Asn Trp 1175 1180 1185 Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 1190 1195 1200 Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser 1205 1210 1215 Ser Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro 1220 1225 1230 Glu Asp Glu Ala Val Tyr Tyr Cys Ala Leu Trp Tyr Pro Asn Leu 1235 1240 1245 Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ala Thr 1250 1255 1260 Pro Pro Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly Glu Thr Thr 1265 1270 1275 Gly Gly Ser Ala Glu Ser Glu Pro Pro Gly Glu Gly Glu Val Gln 1280 1285 1290 Leu Gln Glu Ser Gly Gly Gly Ile Val Gln Pro Gly Gly Ser Leu 1295 1300 1305 Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr Ala 1310 1315 1320 Met Asn Trp Valla Arg Gln A Gly Leu Glu Trp Val 1325 1330 1335 Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala 1340 1345 1350 Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys 1355 1360 Val Gn 1365 Asn Le Thr Met Asn Asn Leu Lys Thr Glu Asp Thr 1370 1375 1380 Ala Val Tyr Tyr Cys Val Arg His Glu Asn Phe Gly Asn Ser Tyr 1385 1390 1395 Val Ser Trp Phe Ala His Trp Gly Gln Gly Thr Leu Val Thr 1400 Ser 14 Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Glu Ser Gly 1415 1420 1425 Arg Ala Ala Asn Thr Gly Pro Pro Thr Leu Thr Ala Pro Pro Gly 1430 1435 1440 Ser Pro Ala Gly Ser Pro T hr Ser Thr Glu Glu Gly Thr Ser Glu 1445 1450 1455 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 1460 1465 1470 Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 1475 1480 1485 Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 1490 1495 1500 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 1505 1510 1515 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 1520 1525 1530 Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 1535 1540 1545 Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 1550 1555 1560 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 1565 1570 1575 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser 1580 1585 1590 Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 1595 1600 1605 Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 1610 1615 1620 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 1625 1630 1635 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Gl u Pro Ser 1640 1645 1650 Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 1655 1660 1665 Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 1670 1675 1680 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 1685 1690 1695 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 1700 1705 1710 Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 1715 1720 1725 Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 1730 1735 1740 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 1745 1750 1755 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 1760 1765 1770 Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 1775 1780 1785 Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 1790 1795 1800 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 1805 1810 1815 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser 1820 1825 1830 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 1835 1840 1845 Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 1850 1855 1860 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 1865 1870 1875 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 1880 1885 1890 Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 1895 1900 1905 Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 1910 1915 1920 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 1925 1930 1935 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 1940 1945 1950 Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 1955 1960 1965 Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 1970 1975 1980 Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 1985 1990 1995 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 2000 2005 2010 Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 2015 2020 2025 Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 2030 2035 2040 Thr Ser Glu Ser Ala Thr P ro Glu Ser Gly Pro Gly Ser Glu Pro 2045 2050 2055 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 2060 2065 2070 Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 2075 2080 2085 Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 2090 2095 2100 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 2105 2110 2115 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 2120 2125 2130 Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 2135 2140 2145 Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 2150 2155 2160 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 2165 2170 2175 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr 2180 2185 2190 Pro Glu Ser Gly Pro Gly Thr Ser Ser Glu Ser Ala Thr Pro Glu Ser 2195 2200 2205 Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 2210 2215 2220 Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala 2225 2230 2235 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Gl u Pro Ser 2240 2245 2250 Glu Gly Ser Ala Pro Gly Thr Glu Ser Thr Pro Ser Glu Gly Ser 2255 2260 2265 Ala Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 2270 2275 2280 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 2285 2290 2295 Glu Pro Ser Glu Gly Ser Ala Pro Gly 2300 2305 <![CDATA[ <210> 19]]>
           <![CDATA[ <211> 1449]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 19]]>
          Ala Ser Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Ser Gly Thr Ser
          1 5 10 15
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
                      20 25 30
          Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  35 40 45
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
              50 55 60
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Thr Pro Ala Glu Ser
          65 70 75 80
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                          85 90 95
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro
                      100 105 110
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
                  115 120 125
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
              130 135 140
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro
          145 150 155 160
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro
                          165 170 175
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
                      180 185 190
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                  195 200 205
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr
              210 215 220
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
          225 230 235 240
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro
                          245 250 255
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser
                      260 265 270
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                  275 280 285
          Pro Gly Gly Ser Ala Pro Ala Ser Gly Arg Ser Thr Asn Ala Gly Pro
              290 295 300
          Pro Gly Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
          305 310 315 320
          Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
                          325 330 335
          Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala
                      340 345 350
          Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
                  355 360 365
          Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly
              370 375 380
          Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
          385 390 395 400
          Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro
                          405 410 415
          Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Ala Thr Pro Pro
                      420 425 430
          Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly Glu Thr Thr Gly Gly Ser
                  435 440 445
          Ala Glu Ser Glu Pro Pro Gly Glu Gly Glu Val Gln Leu Val Glu Ser
              450 455 460
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala
          465 470 475 480
          Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln
                          485 490 495
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn
                      500 505 510
          Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser
                  515 520 525
          Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg
              530 535 540
          Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly
          545 550 555 560
          Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
                          565 570 575
          Ser Gly Gly Gly Ser Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr
                      580 585 590
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly
                  595 600 605
          Ala Val Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly
              610 615 620
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly
          625 630 635 640
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu
                          645 650 655
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala
                      660 665 670
          Leu Trp Tyr Ser Asn Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr
                  675 680 685
          Val Leu Gly Ala Thr Pro Pro Glu Thr Gly Ala Glu Thr Glu Ser Pro
              690 695 700
          Gly Glu Thr Thr Gly Gly Ser Ala Glu Ser Glu Pro Pro Gly Glu Gly
          705 710 715 720
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
                          725 730 735
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr
                      740 745 750
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
                  755 760 765
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp
              770 775 780
          Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
          785 790 795 800
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr
                          805 810 815
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe
                      820 825 830
          Ala Tyr Trp Gly Gly Gly Gly Thr Leu Val Thr Val Ser Ser Ser Gly Thr Ala
                  835 840 845
          Glu Ala Ala Ser Ala Ser Gly Ala Ser Gly Arg Ser Thr Asn Ala Gly
              850 855 860
          Pro Pro Gly Leu Thr Gly Pro Pro Gly Ser Pro Ala Gly Ser Pro Thr
          865 870 875 880
          Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                          885 890 895
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu
                      900 905 910
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu
                  915 920 925
          Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
              930 935 940
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Ser Thr
          945 950 955 960
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu
                          965 970 975
          Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
                      980 985 990
          Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr
                  995 1000 1005
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
              1010 1015 1020
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu
              1025 1030 1035
          Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly
              1040 1045 1050
          Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu
              1055 1060 1065
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
              1070 1075 1080
          Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser
              1085 1090 1095
          Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly
              1100 1105 1110
          Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala
              1115 1120 1125
          Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
              1130 1135 1140
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser
              1145 1150 1155
          Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly
              1160 1165 1170
          Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu
              1175 1180 1185
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
              1190 1195 1200
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser
              1205 1210 1215
          Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
              1220 1225 1230
          Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu
              1235 1240 1245
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
              1250 1255 1260
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser
              1265 1270 1275
          Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly
              1280 1285 1290
          Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr
              1295 1300 1305
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
              1310 1315 1320
          Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser
              1325 1330 1335
          Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly
              1340 1345 1350
          Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro
              1355 1360 1365
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro
              1370 1375 1380
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser
              1385 1390 1395
          Ala Pro Gly Thr Glu Ser Thr Pro Ser Glu Gly Ser Ala Pro Gly
              1400 1405 1410
          Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu
              1415 1420 1425
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
              1430 1435 1440
          Glu Gly Ser Ala Pro Gly
              1445
           <![CDATA[ <210> 20]]>
           <![CDATA[ <211> 2304]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 20]]> Ser Ala Gly Ser Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 1 5 10 15 Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 20 25 30 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro 35 40 45 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 50 55 60 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 65 70 75 80 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Thr Pro Ala Glu Ser 85 90 95 Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 100 105 110 Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 115 120 125 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 130 135 140 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 145 150 155 160 Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 165 170 175 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser 180 185 190 Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 195 200 205 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 210 215 220 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 225 230 235 240 Gly Ser Thr Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 245 250 255 Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr 260 265 270 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala 275 280 285 Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 290 295 300 Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser 305 310 315 320 Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala 325 330 335 Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 340 345 350 Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr 355 360 365 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro 370 375 380 Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 385 390 395 400 Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser 405 410 415 Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro 420 425 430 Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 435 440 445 Gly Pro Gly Ser Glu Pro Ala Thr Ser Ser Gly Ser Glu Thr Pro Gly Thr 450 455 460 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr 465 470 475 480 Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 485 490 495 Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr 500 505 510 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser 515 520 525 Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 530 535 540 Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr 545 550 555 560 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro 565 570 575 Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 580 585 590 Gly Pro Gly Ser Glu Pro Ala Thr Ser Ser Gly Ser Glu Thr Pro Gly Thr 595 600 605 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr 610 615 620 Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 625 630 635 640 Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser 645 650 655 Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala 660 665 670 Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 675 680 685 Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser 690 695 700 Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser 705 710 715 720 Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 725 730 735 Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr 74 0 745 750 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala 755 760 765 Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 770 775 780 Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser 785 790 795 800 Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro 805 810 815 Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 820 825 830 Ala Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 835 840 845 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro 850 855 860 Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 865 870 875 880 Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pr o Gly Thr 885 890 895 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser 900 905 910 Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 915 920 925 Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr 930 935 940 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr 945 950 955 960 Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 965 970 975 Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr 980 985 990 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro 995 1000 1005 Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 1010 1015 1020 Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 1025 1030 1035 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gl y Thr Ser 1040 1045 1050 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala 1055 1060 1065 Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 1070 1075 1080 Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 1085 1090 1095 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 1100 1105 1110 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro 1115 1120 1125 Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 1130 1135 1140 Ser Gly Pro Gly Thr Glu Ser Ala Ser Leu Phe Gly Arg Asn Asp 1145 1150 1155 Asn His Glu Pro Leu Glu Leu Gly Gly Gly Ala Thr Ser Gly Ser 1160 1165 1170 Glu Thr Pro Gly Thr Glu Ile Val Leu Thr Gln Ser Pro Ala Thr 1175 1180 1185 Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Lys Ala 1190 1195 1200 Ser Gln Asp Val Ser Ile Gly Val Ala Trp Tyr Gln Gln Lys Pro 1205 1210 1215 Gly Gln Ala Pro Arg Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr 1220 1225 1230 Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 1235 1240 1245 Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val 1250 1255 1260 Tyr Tyr Cys Gln Gln Tyr Tyr Ile Tyr Pro Tyr Thr Phe Gly Gln 1265 1270 1275 Gly Thr Lys Val Glu Ile Lys Gly Ala Thr Pro Pro Glu Thr Gly 1280 1285 1290 Ala Glu Thr Glu Ser Pro Gly Glu Thr Thr Gly Gly Ser Ala Glu 1295 1300 1305 Ser Glu Pro Pro Gly Glu Gly Gln Val Gln Leu Val Gln Ser Gly 1310 1315 1320 Val Glu Val Lys Lys Pro Gly Ala Ser Lys Val Ser Cys Lys 1325 1330 1335 Ala Ser Gly Phe Thr Phe Thr Asp Tyr Thr Met Asp Trp Val Arg 1340 1345 1350 Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Ala Asp Val Asn Pro 1355 1360 1365 Aslyn Ser Ile Gly Tyr Asn Gln Arg Phe Lys Gly Arg Val 1370 1375 1380 Thr Leu Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr Met Glu Leu 1385 1390 1395 Lys Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg 1400 4105 Leu Gly Pro Ser Phe Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 1415 1420 1425 Leu Val Thr Val Ser Ser Gly Gly Gly Ser Glu Leu Val Val Thr 1430 1435 1440 Gln Glu Pro Ser Leu Thr V al Ser Pro Gly Gly Thr Val Thr Leu 1445 1450 1455 Thr Cys Arg Ser Ser Asn Gly Ala Val Thr Ser Ser Asn Tyr Ala 1460 1465 1470 Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile 1475 1580 Gly Gly 148 Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe Ser 1490 1495 1500 Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 1505 1510 1515 Gln Pro Glu Asp Glu Ala Val Tyr Tyr Cys Ala Leu Trp Tyr Pro 1520 1525 1530 Asn Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 1535 1540 1545 Ala Thr Pro Pro Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly Glu 1550 1555 1560 Thr Thr Gly Gly Ser Ala Glu Ser Glu Pro Pro Gly Glu Gly Glu 1565 1570 1575 Val Gln Leu Leu Glu Ser Gly Gly Gly Ile Val Gln Pro Gly Gly 1580 1585 1590 Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr 1595 1600 1605 Tyr Ala Met Val Arg Asn Gl Trp Ala Pro Gly Lys Gly Leu Glu 1610 1615 1620 Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr 1625 1630 1635 Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Ar g Asp Asp 1640 1645 1650 Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu 1655 1660 1665 Asp Thr Ala Val Tyr Tyr Cys Val Arg His Glu Asn Phe Gly Asn 1670 1675 1680 Serla Hp A Tr Val Ser Trp Gly Gln Gly Thr Leu Val 1685 1690 1695 Thr Val Ser Ser Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Leu 1700 1705 1710 Phe Gly Arg Asn Asp Asn His Glu Pro Leu Glu Leu Gly Gly Gly 1715 1720 1725 Ala Gly S Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 1730 1735 1740 Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 1745 1750 1755 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 1760 1765 1770 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 1775 1780 1785 Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 1790 1795 1800 Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 1805 1810 1815 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu 1820 1825 1830 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro 1835 1840 1845 Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 1850 1855 1860 Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 1865 1870 1875 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 1880 1885 1890 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser 1895 1900 1905 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 1910 1915 1920 Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 1925 1930 1935 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 1940 1945 1950 Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro 1955 1960 1965 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 1970 1975 1980 Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 1985 1990 1995 Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu 2000 2005 2010 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 2015 2020 2025 Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 2030 2035 2040 Gly Pro Gly Thr Ser Thr G lu Pro Ser Glu Gly Ser Ala Pro Gly 2045 2050 2055 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala 2060 2065 2070 Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro 2075 2080 2085 Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 2090 2095 2100 Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 2105 2110 2115 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 2120 2125 2130 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 2135 2140 2145 Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 2150 2155 2160 Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 2165 2170 2175 Thr Ser Glu Ser Ala Ser Pro Glu Ser Gly Pro Gly Thr Ser Thr 2180 2185 2190 Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro 2195 2200 2205 Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 2210 2215 2220 Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 2225 2230 2235 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Se r Pro Ala 2240 2245 2250 Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro 2255 2260 2265 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 2270 2275 2280 Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 2285 2290 2295 Thr Ser Glu Ser Ala Thr 2300 <![CDATA[ <210> 21]]>
           <![CDATA[ <211> 2023]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 21]]> Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 1 5 10 15 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 20 25 30 Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 35 40 45 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 50 55 60 Glu Pro Ser Glu Gly Ser Ala Pro Ala Thr Ser Glu Ser Ala Thr Pro 65 70 75 80 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 85 90 95 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala 100 105 110 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Ser Pro 115 120 125 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Ser Ala Pro 130 135 140 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala 145 150 155 160 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu 165 170 175 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 180 185 190 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 195 200 205 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 210 215 220 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 225 230 235 240 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 245 250 255 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 260 265 270 Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 275 280 285 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 290 295 300 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 305 310 315 320 Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 325 330 335 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 340 345 350 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 355 360 365 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 370 375 380 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 385 390 395 400 Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 405 410 415 Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 420 425 430 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 435 440 445 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 450 455 460 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 465 470 475 480 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 485 490 495 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 500 505 510 Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 515 520 525 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala 530 535 540 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 545 550 555 560 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 565 570 575 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 580 585 590 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 595 600 605 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 610 615 620 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 625 630 635 640 Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 645 650 655 Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 660 665 670 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu 675 680 685 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr 690 695 700 Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Thr Glu Glu 705 710 715 720 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 725 730 735 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro 74 0 745 750 Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 755 760 765 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro 770 775 780 Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr 785 790 795 800 Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 805 810 815 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro 820 825 830 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 835 840 845 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 850 855 860 Thr Thr Gly Arg Ala Gly Glu Ala Glu Gly Ala Thr Ser Ala Gly Ala 865 870 875 880 Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr As p Ile Gln 885 890 895 Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 900 905 910 Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp 915 920 925 Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala 930 935 940 Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser 945 950 955 960 Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 965 970 975 Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly 980 985 990 Gln Gly Thr Lys Val Glu Ile Lys Gly Ala Thr Pro Pro Glu Thr Gly 995 1000 1005 Ala Glu Thr Glu Ser Pro Gly Glu Thr Thr Gly Gly Ser Ala Glu 1010 1015 1020 Ser Glu Pro Pro Gly Glu Gly Glu Val Gln Leu Val Glu Ser Gly 1025 1030 1035 Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Se r Cys Ala 1040 1045 1050 Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg 1055 1060 1065 Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro 1070 1075 1080 Thr Asn Arg Gly Tyr Ar Thr Asp Ser Val Lys Gly Arg Phe 1085 1090 1095 Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met 1100 1105 1110 Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg 1115 1120 Gly Gly Glysp Asp Tr Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gly Gly 1130 1135 1140 Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Glu Leu Val Val 1145 1150 1155 Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr 1160 17065 1 Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr 1175 1180 1185 Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu 1190 1195 1200 Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe 1205 1210 1215 Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly 1220 1225 1230 Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr 1235 1240 1245 Ser Asn Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 1250 1255 1260 Gly Ala Thr Pro Pro Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly 1265 1270 1275 Glu Thr Gly Gly Ser Ala Glu Ser Glu Pro Pro Pro Gly Glu Gly 1280 1285 1290 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 1295 1300 1305 Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn 1310 1315 1320 Thr Tyr Ala Met Asg Gln Arla Val Pro Gly Lys Gly Leu 1325 1330 1335 Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 1340 1345 1350 Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp 1355 1360 Thlays Asp Ser A L Tyr Leu Gln Met Asn Asn Leu Lys Thr 1370 1375 1380 Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly 1385 1390 1395 Asn Ser Tyr Val Ser Trp Phe Ala Tyr Trp Gly Gl1 Val Thr Leu 1400 Val Ser Ser Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly 1415 1420 1425 Thr Thr Gly Arg Ala Gly Glu Ala Glu Gly Ala Thr Ser Ala Gly 1430 1435 1440 Ala Thr Gly Pro Gly Ser G lu Thr Pro Gly Ser Pro Ala Gly Ser 1445 1450 1455 Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu 1460 1465 1470 Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 1475 1480 1485 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro 1490 1495 1500 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro 1505 1510 1515 Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 1520 1525 1530 Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 1535 1540 1545 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 1550 1555 1560 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr 1565 1570 1575 Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 1580 1585 1590 Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 1595 1600 1605 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 1610 1615 1620 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser 1625 1630 1635 Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Th r Pro Glu 1640 1645 1650 Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 1655 1660 1665 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 1670 1675 1680 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro 1685 1690 1695 Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 1700 1705 1710 Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 1715 1720 1725 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 1730 1735 1740 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser 1745 1750 1755 Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly 1760 1765 1770 Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 1775 1780 1785 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 1790 1795 1800 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr 1805 1810 1815 Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 1820 1825 1830 Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 1835 1840 1845 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro 1850 1855 1860 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser 1865 1870 1875 Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser 1880 1885 1890 Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 1895 1900 1905 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 1910 1915 1920 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr 1925 1930 1935 Ser Gly Ser Thr Glu Thr Gly Thr Ser Glu Ser Ala Thr Pro Glu 1940 1945 1950 Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Ser Gly Ser Glu Thr Pro 1955 1960 1965 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 1970 1975 1980 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser 1985 1990 1995 Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu 2000 2005 2010 Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 2015 2020 <![CDATA[ <210> 22]]>
           <![CDATA[ <211> 1736]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 22]]> Ala Ser Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Ser Gly Thr Ser 1 5 10 15 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Glu Thr Glu Pro Ser 20 25 30 Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 35 40 45 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 50 55 60 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Thr Pro Ala Glu Ser 65 70 75 80 Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 85 90 95 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro 100 105 110 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr 115 120 125 Pro Glu Ser Gly Pro Gly Glu Ser Pro Ala Thr Ser Gly Ser Thr Pro 130 135 140 Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro 145 150 155 160 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro 165 170 175 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 180 185 190 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 195 200 205 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr 210 215 220 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 225 230 235 240 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro 245 250 255 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser 260 265 270 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 275 280 285 Pro Gly Gly Ser Ala Pro Ala Ser Gly Arg Gly Thr Asn Ala Gly Pro 290 295 300 Ala Gly Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 305 310 315 320 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 325 330 335 Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ile Gly 340 345 350 Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 355 360 365 Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 370 375 380 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 385 390 395 400 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ile Tyr Pro Tyr 405 410 415 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Ala Thr Pro 420 425 430 Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly Glu Thr Thr Gly Gly Ser 435 440 445 Ala Glu Ser Glu Pro Pro Gly Glu Gly Glu Val Gln Leu Val Glu Ser 450 455 460 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 465 470 475 480 Ala Ser Gly Phe Thr Phe Thr Asp Tyr Thr Met Asp Trp Val Arg Gln 485 490 495 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Asp Val Asn Pro Asn Ser 500 505 510 Gly Gly Ser Ile Tyr Asn Gln Arg Phe Lys Gly Arg Phe Thr Leu Ser 515 520 525 Val Asp Arg Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 530 535 540 Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn Leu Gly Pro Ser 545 550 555 560 Phe Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 565 570 575 Gly Gly Gly Ser Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val 580 585 590 Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser Ser Asn Gly Ala 595 600 605 Val Thr Ser Ser Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln 610 615 620 Ala Pro Arg Gly Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr 625 630 635 640 Pro Ala Arg Phe Ser Gly Ser Ser Leu Gly Gly Lys Ala Ala Leu Thr 645 650 655 Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Val Tyr Tyr Cys Ala Leu 660 665 670 Trp Tyr Pro Asn Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val 675 680 685 Leu Gly Ala Thr Pro Pro Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly 690 695 700 Glu Thr Thr Gly Gly Ser Ala Glu Ser Glu Pro Pro Gly Glu Gly Glu 705 710 715 720 Val Gln Leu Gln Glu Ser Gly Gly Gly Ile Val Gln Pro Gly Gly Ser 725 730 735 Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr Ala 74 0 745 750 Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 755 760 765 Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 770 775 780 Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Val 785 790 795 800 Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr 805 810 815 Cys Val Arg His Glu Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala 823 0 His 8 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Gly Thr Ala Glu 835 840 845 Ala Ala Ser Ala Ser Gly Ala Ser Gly Arg Gly Thr Asn Ala Gly Pro 850 855 860 Ala Gly Leu Thr Gly Pro Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 865 870 875 880 Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gl y Pro Gly 885 890 895 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly 900 905 910 Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Ser Thr Glu Pro Ser Glu Gly 915 920 925 Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 930 935 940 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala 945 950 955 960 Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 965 970 975 Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 980 985 990 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu 995 1000 1005 Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 1010 1015 1020 Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 1025 1030 1035 Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pr o Gly Thr 1040 1045 1050 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser 1055 1060 1065 Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 1070 1075 1080 Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 1085 1090 1095 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 1100 1105 1110 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu 1115 1120 1125 Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 1130 1135 1140 Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 1145 1150 1155 Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr 1160 1165 1170 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala 1175 1180 1185 Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 1190 1195 1200 Glu Ser Gly Pro Gly Thr Ser Thr Ser Gly Pro Ser Glu Gly Ser Ala 1205 1210 1215 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr 1220 1225 1230 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu 1235 1240 1245 Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 1250 1255 1260 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 1265 1270 1275 Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr 1280 1285 1290 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser 1295 1300 1305 Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 1310 1315 1320 Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 1325 1330 1335 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 1340 1345 1350 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu 1355 1360 1365 Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 1370 1375 1380 Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 1385 1390 1395 Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser 1400 1405 1410 Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser 1415 1420 1425 Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 1430 1435 1440 Gly Ser Ala Pro Gly Thr S er Glu Ser Ala Thr Pro Glu Ser Gly 1445 1450 1455 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 1460 1465 1470 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala 1475 1480 1485 Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 1490 1495 1500 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 1505 1510 1515 Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr 1520 1525 1530 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala 1535 1540 1545 Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr Pro 1550 1555 1560 Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 1565 1570 1575 Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr 1580 1585 1590 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser 1595 1600 1605 Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro 1610 1615 1620 Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 1625 1630 1635 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pr o Gly Ser 1640 1645 1650 Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly 1655 1660 1665 Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu 1670 1675 1680 Gly Ser Ala Pro Gly Thr Glu Ser Thr Pro Ser Glu Gly Ser Ala 1685 1690 1695 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 1700 1705 1710 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu 1715 1720 1725 Pro Ser Glu Gly Ser Ala Pro Gly 1730 1735 <![CDATA[ <210> 23]]>
           <![CDATA[ <211> 1745]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 23]]> Ala Ser Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Ser Gly Thr Ser 1 5 10 15 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 20 25 30 Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 35 40 45 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 50 55 60 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Thr Pro Ala Glu Ser 65 70 75 80 Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 85 90 95 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro 100 105 110 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr 115 120 125 Pro Glu Ser Gly Pro Gly Glu Glu Pro Ala Thr Ser Gly Ser Thr Pro 130 135 140 Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro 145 150 155 160 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro 165 170 175 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 180 185 190 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 195 200 205 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr 210 215 220 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 225 230 235 240 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro 245 250 255 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser 260 265 270 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Ser Ala 275 280 285 Pro Gly Gly Ser Ala Pro Gly Ala Gly Arg Thr Asp Asn His Glu Pro 290 295 300 Leu Glu Leu Gly Ala Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 305 310 315 320 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 325 330 335 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 340 345 350 Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 355 360 365 Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 370 375 380 Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Leu Gln Pro 385 390 395 400 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 405 410 415 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Ala Thr Pro Pro 420 425 430 Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly Glu Thr Thr Gly Gly Ser 435 440 445 Ala Glu Ser Glu Pro Pro Gly Glu Gly Glu Val Gln Leu Val Glu Ser 450 455 460 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 465 470 475 480 Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln 485 490 495 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn 500 505 510 Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 515 520 525 Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg 530 535 540 Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly 545 550 555 560 Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 565 570 575 Ser Gly Gly Gly Ser Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr 580 585 590 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly 595 600 605 Ala Val Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly 610 615 620 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly 625 630 635 640 Thr Pro Ala Arg Phe Ser Gly Ser Ser Leu Gly Gly Ser Ala Ala Leu 645 650 655 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala 660 665 670 Leu Trp Tyr Ser Asn Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 675 680 685 Val Leu Gly Ala Thr Pro Pro Glu Thr Gly Ala Glu Thr Glu Ser Pro 690 695 700 Gly Glu Thr Thr Gly Gly Ser Ala Glu Ser Glu Pro Pro Gly Glu Gly 705 710 715 720 Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 725 730 735 Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 74 0 745 750 Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 755 760 765 Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 770 775 780 Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 785 790 795 800 Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 805 810 815 Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 823 0 Ala 8 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Thr Ala 835 840 845 Glu Ala Ala Ser Ala Ser Gly Gly Ala Gly Arg Thr Asp Asn His Glu 850 855 860 Pro Leu Glu Leu Gly Ala Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 865 870 875 880 Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Se r Gly Pro 885 890 895 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala 900 905 910 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu 915 920 925 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 930 935 940 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 945 950 955 960 Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly 965 970 975 Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 980 985 990 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 995 1000 1005 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser 1010 1015 1020 Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 1025 1030 1035 Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Al a Pro Gly 1040 1045 1050 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 1055 1060 1065 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 1070 1075 1080 Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 1085 1090 1095 Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 1100 1105 1110 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 1115 1120 1125 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 1130 1135 1140 Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 1145 1150 1155 Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 1160 1165 1170 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 1175 1180 1185 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 1190 1195 1200 Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 1205 1210 1215 Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 1220 1225 1230 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 1235 1240 1245 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser 1250 1255 1260 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 1265 1270 1275 Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 1280 1285 1290 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 1295 1300 1305 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 1310 1315 1320 Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 1325 1330 1335 Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 1340 1345 1350 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 1355 1360 1365 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 1370 1375 1380 Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 1385 1390 1395 Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 1400 1405 1410 Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 1415 1420 1425 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 1430 1435 1440 Glu Gly Ser Ala Pro Gly T hr Ser Glu Ser Ala Thr Pro Glu Ser 1445 1450 1455 Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 1460 1465 1470 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 1475 1480 1485 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 1490 1495 1500 Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 1505 1510 1515 Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 1520 1525 1530 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 1535 1540 1545 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 1550 1555 1560 Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 1565 1570 1575 Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 1580 1585 1590 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 1595 1600 1605 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr 1610 1615 1620 Pro Glu Ser Gly Pro Gly Phe Thr Ala Asx Thr Ser Glu Ser Ala 1625 1630 1635 Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Se r Gly Pro 1640 1645 1650 Thr Glu Ser Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 1655 1660 1665 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 1670 1675 1680 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Glu Ser Thr Pro 1685 1690 1695 Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 1700 1705 1710 Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 1715 1720 1725 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Glu Pro 1730 1735 1740 Glu Ala 1745 <![CDATA[ <210> 24]]>
           <![CDATA[ <211> 2304]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 24]]> Ser Ala Gly Ser Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 1 5 10 15 Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 20 25 30 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro 35 40 45 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 50 55 60 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 65 70 75 80 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Thr Pro Ala Glu Ser 85 90 95 Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 100 105 110 Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 115 120 125 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 130 135 140 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 145 150 155 160 Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 165 170 175 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser 180 185 190 Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 195 200 205 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 210 215 220 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 225 230 235 240 Gly Ser Thr Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 245 250 255 Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr 260 265 270 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala 275 280 285 Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 290 295 300 Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser 305 310 315 320 Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala 325 330 335 Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 340 345 350 Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr 355 360 365 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro 370 375 380 Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 385 390 395 400 Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser 405 410 415 Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro 420 425 430 Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 435 440 445 Gly Pro Gly Ser Glu Pro Ala Thr Ser Ser Gly Ser Glu Thr Pro Gly Thr 450 455 460 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr 465 470 475 480 Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 485 490 495 Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr 500 505 510 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser 515 520 525 Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 530 535 540 Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr 545 550 555 560 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro 565 570 575 Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 580 585 590 Gly Pro Gly Ser Glu Pro Ala Thr Ser Ser Gly Ser Glu Thr Pro Gly Thr 595 600 605 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr 610 615 620 Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 625 630 635 640 Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser 645 650 655 Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala 660 665 670 Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 675 680 685 Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser 690 695 700 Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser 705 710 715 720 Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 725 730 735 Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr 74 0 745 750 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala 755 760 765 Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 770 775 780 Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser 785 790 795 800 Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro 805 810 815 Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 820 825 830 Ala Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 835 840 845 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro 850 855 860 Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 865 870 875 880 Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pr o Gly Thr 885 890 895 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser 900 905 910 Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 915 920 925 Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr 930 935 940 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr 945 950 955 960 Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 965 970 975 Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr 980 985 990 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro 995 1000 1005 Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 1010 1015 1020 Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 1025 1030 1035 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gl y Thr Ser 1040 1045 1050 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala 1055 1060 1065 Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 1070 1075 1080 Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 1085 1090 1095 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 1100 1105 1110 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro 1115 1120 1125 Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 1130 1135 1140 Ser Gly Pro Gly Thr Glu Ser Ala Ser Ala Ser Gly Arg Ala Ala 1145 1150 1155 Asn Glu Thr Pro Pro Gly Leu Thr Gly Ala Ala Thr Ser Gly Ser 1160 1165 1170 Glu Thr Pro Gly Thr Glu Ile Val Leu Thr Gln Ser Pro Ala Thr 1175 1180 1185 Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Lys Ala 1190 1195 1200 Ser Gln Asp Val Ser Ile Gly Val Ala Trp Tyr Gln Gln Lys Pro 1205 1210 1215 Gly Gln Ala Pro Arg Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr 1220 1225 1230 Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 1235 1240 1245 Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val 1250 1255 1260 Tyr Tyr Cys Gln Gln Tyr Tyr Ile Tyr Pro Tyr Thr Phe Gly Gln 1265 1270 1275 Gly Thr Lys Val Glu Ile Lys Gly Ala Thr Pro Pro Glu Thr Gly 1280 1285 1290 Ala Glu Thr Glu Ser Pro Gly Glu Thr Thr Gly Gly Ser Ala Glu 1295 1300 1305 Ser Glu Pro Pro Gly Glu Gly Gln Val Gln Leu Val Gln Ser Gly 1310 1315 1320 Val Glu Val Lys Lys Pro Gly Ala Ser Lys Val Ser Cys Lys 1325 1330 1335 Ala Ser Gly Phe Thr Phe Thr Asp Tyr Thr Met Asp Trp Val Arg 1340 1345 1350 Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Ala Asp Val Asn Pro 1355 1360 1365 Aslyn Ser Ile Gly Tyr Asn Gln Arg Phe Lys Gly Arg Val 1370 1375 1380 Thr Leu Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr Met Glu Leu 1385 1390 1395 Lys Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg 1400 4105 Leu Gly Pro Ser Phe Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 1415 1420 1425 Leu Val Thr Val Ser Ser Gly Gly Gly Ser Glu Leu Val Val Thr 1430 1435 1440 Gln Glu Pro Ser Leu Thr V al Ser Pro Gly Gly Thr Val Thr Leu 1445 1450 1455 Thr Cys Arg Ser Ser Asn Gly Ala Val Thr Ser Ser Asn Tyr Ala 1460 1465 1470 Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile 1475 1580 Gly Gly 148 Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe Ser 1490 1495 1500 Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 1505 1510 1515 Gln Pro Glu Asp Glu Ala Val Tyr Tyr Cys Ala Leu Trp Tyr Pro 1520 1525 1530 Asn Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 1535 1540 1545 Ala Thr Pro Pro Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly Glu 1550 1555 1560 Thr Thr Gly Gly Ser Ala Glu Ser Glu Pro Pro Gly Glu Gly Glu 1565 1570 1575 Val Gln Leu Leu Glu Ser Gly Gly Gly Ile Val Gln Pro Gly Gly 1580 1585 1590 Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr 1595 1600 1605 Tyr Ala Met Val Arg Asn Gl Trp Ala Pro Gly Lys Gly Leu Glu 1610 1615 1620 Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr 1625 1630 1635 Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Ar g Asp Asp 1640 1645 1650 Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu 1655 1660 1665 Asp Thr Ala Val Tyr Tyr Cys Val Arg His Glu Asn Phe Gly Asn 1670 1675 1680 Serla Hp A Tr Val Ser Trp Gly Gln Gly Thr Leu Val 1685 1690 1695 Thr Val Ser Ser Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ala 1700 1705 1710 Ser Gly Arg Ala Ala Asn Glu Thr Pro Gly Leu Thr Gly Thr Ala 1715 1720 1725 Gly Ser Glu Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 1730 1735 1740 Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 1745 1750 1755 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 1760 1765 1770 Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro 1775 1780 1785 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 1790 1795 1800 Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 1805 1810 1815 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 1820 1825 1830 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 1835 1840 1845 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 1850 1855 1860 Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 1865 1870 1875 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 1880 1885 1890 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr 1895 1900 1905 Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 1910 1915 1920 Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 1925 1930 1935 Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu 1940 1945 1950 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 1955 1960 1965 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 1970 1975 1980 Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 1985 1990 1995 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 2000 2005 2010 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser 2015 2020 2025 Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 2030 2035 2040 Glu Glu Gly Thr Ser Thr G lu Pro Ser Glu Gly Ser Ala Pro Gly 2045 2050 2055 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 2060 2065 2070 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 2075 2080 2085 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 2090 2095 2100 Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 2105 2110 2115 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 2120 2125 2130 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro 2135 2140 2145 Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 2150 2155 2160 Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 2165 2170 2175 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 2180 2185 2190 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 2195 2200 2205 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Thr 2210 2215 2220 Glu Thr Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 2225 2230 2235 Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Th r Ser Glu 2240 2245 2250 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 2255 2260 2265 Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 2270 2275 2280 Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 2285 2290 2295 Ser Glu Pro Ala Thr Ser 2300 <![CDATA[ <210> 25]]>
           <![CDATA[ <211> 2016]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 25]]> Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 1 5 10 15 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 20 25 30 Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 35 40 45 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 50 55 60 Glu Pro Ser Glu Gly Ser Ala Pro Ala Thr Ser Glu Ser Ala Thr Pro 65 70 75 80 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 85 90 95 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala 100 105 110 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Ser Pro 115 120 125 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Ser Ala Pro 130 135 140 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala 145 150 155 160 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu 165 170 175 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 180 185 190 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 195 200 205 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 210 215 220 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 225 230 235 240 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 245 250 255 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 260 265 270 Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 275 280 285 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 290 295 300 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 305 310 315 320 Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 325 330 335 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 340 345 350 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 355 360 365 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 370 375 380 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 385 390 395 400 Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 405 410 415 Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 420 425 430 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 435 440 445 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 450 455 460 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 465 470 475 480 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 485 490 495 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 500 505 510 Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 515 520 525 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala 530 535 540 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 545 550 555 560 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 565 570 575 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 580 585 590 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 595 600 605 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 610 615 620 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 625 630 635 640 Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 645 650 655 Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 660 665 670 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu 675 680 685 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr 690 695 700 Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Thr Glu Glu 705 710 715 720 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 725 730 735 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro 74 0 745 750 Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 755 760 765 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro 770 775 780 Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr 785 790 795 800 Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 805 810 815 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro 820 825 830 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 835 840 845 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 850 855 860 Ala Ser Gly Arg Ser Thr Asn Ala Gly Pro Pro Gly Leu Thr Gly Pro 865 870 875 880 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Glu Ile Val Le u Thr Gln 885 890 895 Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 900 905 910 Cys Lys Ala Ser Gln Asp Val Ser Ile Gly Val Ala Trp Tyr Gln Gln 915 920 925 Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Ser Ala Ser Tyr Arg 930 935 940 Tyr Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 945 950 955 960 Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr 965 970 975 Tyr Cys Gln Gln Tyr Tyr Ile Tyr Pro Tyr Thr Phe Gly Gln Gly Thr 980 985 990 Lys Val Glu Ile Lys Gly Ala Thr Pro Pro Glu Thr Gly Ala Glu Thr 995 1000 1005 Glu Ser Pro Gly Glu Thr Thr Thr Gly Gly Ser Ala Glu Ser Glu Pro 1010 1015 1020 Pro Gly Glu Gly Gln Val Gln Leu Val Gln Ser Gly Val Glu Val 1025 1030 1035 Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Al a Ser Gly 1040 1045 1050 Phe Thr Phe Thr Asp Tyr Thr Met Asp Trp Val Arg Gln Ala Pro 1055 1060 1065 Gly Gln Gly Leu Glu Trp Met Ala Asp Val Asn Pro Asn Ser Gly 1070 1075 1080 Gly Ser Phe Gln Tyr Asn Lys Gly Arg Val Thr Leu Thr 1085 1090 1095 Thr Asp Ser Ser Thr Thr Thr Ala Tyr Met Glu Leu Lys Ser Leu 1100 1105 1110 Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn Leu Gly 1115 1120 Phe Tyr Pro Ser Phe Asp Tyr Trp Gly Gly Gly Gly Thr Leu Val Thr 1130 1135 1140 Val Ser Ser Gly Gly Gly Gly Ser Glu Leu Val Thr Gln Glu Pro 1145 1150 1155 Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Arg 1160 1165 1 Ser Ser Asn Gly Ala Val Thr Ser Ser Ser Asn Tyr Ala Asn Trp Val 1175 1180 1185 Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr 1190 1195 1200 Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Ser 1205 1210 1215 Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu 1220 1225 1230 Asp Glu Ala Val Tyr Tyr Cys Ala Leu Trp Tyr Pro Asn Leu Trp 1235 1240 1245 Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ala Thr Pro 1250 1255 1260 Pro Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly Glu Thr Thr Gly 1265 1270 1275 Gly Ser Ala Glu Ser Glu Pro Pro Gly Glu Gly Glu Val Gln Leu 1280 1285 1290 Gln Glu Ser Gly Gly Gly Ile Val Gln Pro Gly Gly Ser Leu Lys 1295 1300 1305 Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr Ala Met 1310 1315 1320 Asn Trp Val Argly Gln Gla Pro G Leu Glu Trp Val Ala 1325 1330 1335 Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 1340 1345 1350 Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn 1355 1360 Val Tyr Tyr Tyr Ala Asp 1355 1360 Val Tyr Tyr Tyr M Leu Thr G Asn Asn Leu Lys Thr Glu Asp Thr Ala 1370 1375 1380 Val Tyr Tyr Cys Val Arg His Glu Asn Phe Gly Asn Ser Tyr Val 1385 1390 1395 Ser Trp Phe Ala His Trp Gly Gly Gly Thr Leu Val S5 Thr Val Ser 1400 G1400 41 14 Thr Ala Glu Ala Ala Ser Ala Ser Gly Ala Ser Gly Arg 1415 1420 1425 Ser Thr Asn Ala Gly Pro Pro Gly Leu Thr Gly Pro Gly Ser Glu 1430 1435 1440 Thr Pro Gly Ser Pro Ala G ly Ser Pro Thr Ser Thr Glu Glu Gly 1445 1450 1455 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 1460 1465 1470 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser 1475 1480 1485 Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 1490 1495 1500 Glu Glu Gly Thr Ser Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 1505 1510 1515 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 1520 1525 1530 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 1535 1540 1545 Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 1550 1555 1560 Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 1565 1570 1575 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 1580 1585 1590 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 1595 1600 1605 Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 1610 1615 1620 Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 1625 1630 1635 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Se r Glu Pro 1640 1645 1650 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 1655 1660 1665 Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 1670 1675 1680 Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 1685 1690 1695 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 1700 1705 1710 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser 1715 1720 1725 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 1730 1735 1740 Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 1745 1750 1755 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 1760 1765 1770 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 1775 1780 1785 Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 1790 1795 1800 Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 1805 1810 1815 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 1820 1825 1830 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 1835 1840 1845 Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 1850 1855 1860 Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 1865 1870 1875 Ser Pro Ala Gly Ser Pro Thr Ser Ser Thr Glu Glu Gly Thr Ser Glu 1880 1885 1890 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 1895 1900 1905 Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 1910 1915 1920 Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Thr Glu Thr Gly 1925 1930 1935 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 1940 1945 1950 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 1955 1960 1965 Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 1970 1975 1980 Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 1985 1990 1995 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 2000 2005 2010 Ala Thr Ser 2015 <![CDATA[ <210> 26]]>
           <![CDATA[ <211> 1454]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 26]]>
          Ala Ser Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Ser Gly Thr Ser
          1 5 10 15
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
                      20 25 30
          Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  35 40 45
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
              50 55 60
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Thr Pro Ala Glu Ser
          65 70 75 80
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                          85 90 95
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro
                      100 105 110
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
                  115 120 125
          Pro Glu Ser Gly Pro Gly Glu Glu Pro Ala Thr Ser Gly Ser Thr Pro
              130 135 140
          Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro
          145 150 155 160
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro
                          165 170 175
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
                      180 185 190
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                  195 200 205
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr
              210 215 220
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
          225 230 235 240
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro
                          245 250 255
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser
                      260 265 270
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                  275 280 285
          Pro Gly Gly Ser Ala Pro Arg Thr Gly Arg Thr Gly Glu Ser Ala Asn
              290 295 300
          Glu Thr Pro Ala Gly Leu Gly Gly Pro Ala Thr Ser Gly Ser Glu Thr
          305 310 315 320
          Pro Gly Thr Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu
                          325 330 335
          Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Asp Val
                      340 345 350
          Ser Ile Gly Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg
                  355 360 365
          Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ala Arg
              370 375 380
          Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser
          385 390 395 400
          Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Ile
                          405 410 415
          Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Ala
                      420 425 430
          Thr Pro Pro Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly Glu Thr Thr
                  435 440 445
          Gly Gly Ser Ala Glu Ser Glu Pro Pro Gly Glu Gly Gln Val Gln Leu
              450 455 460
          Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val
          465 470 475 480
          Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Asp Tyr Thr Met Asp Trp
                          485 490 495
          Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Ala Asp Val Asn
                      500 505 510
          Pro Asn Ser Gly Gly Ser Ile Tyr Asn Gln Arg Phe Lys Gly Arg Val
                  515 520 525
          Thr Leu Thr Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr Met Glu Leu Lys
              530 535 540
          Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn Leu
          545 550 555 560
          Gly Pro Ser Phe Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr
                          565 570 575
          Val Ser Ser Gly Gly Gly Ser Glu Leu Val Val Thr Gln Glu Pro Ser
                      580 585 590
          Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser Ser
                  595 600 605
          Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Gln Lys
              610 615 620
          Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Asn Lys Arg Ala
          625 630 635 640
          Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Ser Leu Gly Gly Ser Ala
                          645 650 655
          Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr
                      660 665 670
          Cys Ala Leu Trp Tyr Ser Asn Leu Trp Val Phe Gly Gly Gly Thr Lys
                  675 680 685
          Leu Thr Val Leu Gly Ala Thr Pro Pro Glu Thr Gly Ala Glu Thr Glu
              690 695 700
          Ser Pro Gly Glu Thr Thr Gly Gly Ser Ala Glu Ser Glu Pro Pro Gly
          705 710 715 720
          Glu Gly Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro
                          725 730 735
          Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn
                      740 745 750
          Thr Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu
                  755 760 765
          Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr
              770 775 780
          Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys
          785 790 795 800
          Asn Thr Ala Tyr Leu Gln Met Asn Asn Asn Leu Lys Thr Glu Asp Thr Ala
                          805 810 815
          Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser
                      820 825 830
          Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly
                  835 840 845
          Thr Ala Glu Ala Ala Ser Ala Ser Gly Arg Thr Gly Arg Thr Gly Glu
              850 855 860
          Ser Ala Asn Glu Thr Pro Ala Gly Leu Gly Gly Pro Pro Gly Ser Pro
          865 870 875 880
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
                          885 890 895
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
                      900 905 910
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                  915 920 925
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser
              930 935 940
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
          945 950 955 960
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                          965 970 975
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser
                      980 985 990
          Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
                  995 1000 1005
          Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr
              1010 1015 1020
          Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala
              1025 1030 1035
          Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro
              1040 1045 1050
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
              1055 1060 1065
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr
              1070 1075 1080
          Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser
              1085 1090 1095
          Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr
              1100 1105 1110
          Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
              1115 1120 1125
          Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr
              1130 1135 1140
          Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu
              1145 1150 1155
          Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro
              1160 1165 1170
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
              1175 1180 1185
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser
              1190 1195 1200
          Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser
              1205 1210 1215
          Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu
              1220 1225 1230
          Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
              1235 1240 1245
          Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser
              1250 1255 1260
          Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser
              1265 1270 1275
          Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr
              1280 1285 1290
          Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
              1295 1300 1305
          Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr
              1310 1315 1320
          Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser
              1325 1330 1335
          Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro
              1340 1345 1350
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
              1355 1360 1365
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser
              1370 1375 1380
          Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu
              1385 1390 1395
          Pro Ser Glu Gly Ser Ala Pro Gly Thr Glu Ser Thr Pro Ser Glu
              1400 1405 1410
          Gly Ser Ala Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
              1415 1420 1425
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr
              1430 1435 1440
          Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
              1445 1450
           <![CDATA[ <210> 27]]>
           <![CDATA[ <211> 1744]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 27]]> Ala Ser Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Ser Gly Thr Ser 1 5 10 15 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 20 25 30 Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 35 40 45 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 50 55 60 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Thr Pro Ala Glu Ser 65 70 75 80 Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 85 90 95 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro 100 105 110 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr 115 120 125 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 130 135 140 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro 145 150 155 160 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro 165 170 175 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 180 185 190 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 195 200 205 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr 210 215 220 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 225 230 235 240 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro 245 250 255 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser 260 265 270 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Ser Ala 275 280 285 Pro Gly Gly Ser Ala Pro Leu Phe Gly Arg Asn Asp Asn His Glu Pro 290 295 300 Leu Glu Leu Gly Gly Gly Gly Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 305 310 315 320 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 325 330 335 Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ile Gly 340 345 350 Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 355 360 365 Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 370 375 380 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 385 390 395 400 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ile Tyr Pro Tyr 405 410 415 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Ala Thr Pro 420 425 430 Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly Glu Thr Thr Gly Gly Ser 435 440 445 Ala Glu Ser Glu Pro Pro Gly Glu Gly Glu Val Gln Leu Val Glu Ser 450 455 460 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 465 470 475 480 Ala Ser Gly Phe Thr Phe Thr Asp Tyr Thr Met Asp Trp Val Arg Gln 485 490 495 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Asp Val Asn Pro Asn Ser 500 505 510 Gly Gly Ser Ile Tyr Asn Gln Arg Phe Lys Gly Arg Phe Thr Leu Ser 515 520 525 Val Asp Arg Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 530 535 540 Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn Leu Gly Pro Ser 545 550 555 560 Phe Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 565 570 575 Gly Gly Gly Ser Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val 580 585 590 Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala 595 600 605 Val Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln 610 615 620 Ala Pro Arg Gly Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr 625 630 635 640 Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr 645 650 655 Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu 660 665 670 Trp Tyr Ser Asn Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val 675 680 685 Leu Gly Ala Thr Pro Pro Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly 690 695 700 Glu Thr Thr Gly Gly Ser Ala Glu Ser Glu Pro Pro Gly Glu Gly Glu 705 710 715 720 Val Gln Leu Leu Glu Ser Pro Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 725 730 735 Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr Ala 74 0 745 750 Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 755 760 765 Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 770 775 780 Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala 785 790 795 800 Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr 805 810 815 Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala 823 0 Tyr 8 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Gly Thr Ala Glu 835 840 845 Ala Ala Ser Ala Ser Gly Leu Phe Gly Arg Asn Asp Asn His Glu Pro 850 855 860 Leu Glu Leu Gly Gly Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 865 870 875 880 Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gl y Pro Gly 885 890 895 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly 900 905 910 Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Ser Thr Glu Pro Ser Glu Gly 915 920 925 Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 930 935 940 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala 945 950 955 960 Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 965 970 975 Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 980 985 990 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu 995 1000 1005 Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 1010 1015 1020 Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 1025 1030 1035 Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pr o Gly Thr 1040 1045 1050 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser 1055 1060 1065 Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 1070 1075 1080 Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 1085 1090 1095 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 1100 1105 1110 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu 1115 1120 1125 Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 1130 1135 1140 Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 1145 1150 1155 Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr 1160 1165 1170 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala 1175 1180 1185 Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 1190 1195 1200 Glu Ser Gly Pro Gly Thr Ser Thr Ser Gly Pro Ser Glu Gly Ser Ala 1205 1210 1215 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr 1220 1225 1230 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu 1235 1240 1245 Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 1250 1255 1260 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 1265 1270 1275 Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr 1280 1285 1290 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser 1295 1300 1305 Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 1310 1315 1320 Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 1325 1330 1335 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 1340 1345 1350 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu 1355 1360 1365 Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 1370 1375 1380 Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 1385 1390 1395 Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser 1400 1405 1410 Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser 1415 1420 1425 Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 1430 1435 1440 Gly Ser Ala Pro Gly Thr S er Glu Ser Ala Thr Pro Glu Ser Gly 1445 1450 1455 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 1460 1465 1470 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala 1475 1480 1485 Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 1490 1495 1500 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 1505 1510 1515 Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr 1520 1525 1530 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala 1535 1540 1545 Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr Pro 1550 1555 1560 Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 1565 1570 1575 Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr 1580 1585 1590 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser 1595 1600 1605 Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro 1610 1615 1620 Glu Ser Gly Pro Gly Phe Thr Ala Asx Thr Ser Glu Ser Ala Thr 1625 1630 1635 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gl y Pro Thr 1640 1645 1650 Glu Ser Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 1655 1660 1665 Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr 1670 1675 1680 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Glu Ser Thr Pro Ser 1685 1690 1695 Glu Gly Ser Ala Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 1700 1705 1710 Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 1715 1720 1725 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Glu Pro Glu 1730 1735 1740 Ala <![CDATA[ <210> 28]]>
           <![CDATA[ <211> 2030]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 28]]> Ala Ser Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Ser Gly Thr Ser 1 5 10 15 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Glu Thr Glu Pro Ser 20 25 30 Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 35 40 45 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 50 55 60 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Thr Pro Ala Glu Ser 65 70 75 80 Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 85 90 95 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro 100 105 110 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr 115 120 125 Pro Glu Ser Gly Pro Gly Glu Ser Pro Ala Thr Ser Gly Ser Thr Pro 130 135 140 Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro 145 150 155 160 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro 165 170 175 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 180 185 190 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 195 200 205 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr 210 215 220 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 225 230 235 240 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro 245 250 255 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser 260 265 270 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 275 280 285 Pro Gly Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn 290 295 300 Ala Thr Ser Ala Gly Ala Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr 305 310 315 320 Pro Gly Thr Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 325 330 335 Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val 340 345 350 Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 355 360 365 Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg 370 375 380 Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 385 390 395 400 Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr 405 410 415 Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Ala 420 425 430 Thr Pro Pro Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly Glu Thr Thr 435 440 445 Gly Gly Ser Ala Glu Ser Glu Pro Pro Gly Glu Gly Glu Val Gln Leu 450 455 460 Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 465 470 475 480 Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp 485 490 495 Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr 500 505 510 Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe 515 520 525 Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn 530 535 540 Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly 545 550 555 560 Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 565 570 575 Thr Val Ser Ser Gly Gly Gly Ser Glu Leu Val Val Thr Gln Glu Pro 580 585 590 Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser 595 600 605 Ser Asn Gly Ala Val Thr Ser Ser Asn Tyr Ala Asn Trp Val Gln Gln 610 615 620 Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Asn Lys Arg 625 630 635 640 Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys 645 650 655 Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Val Tyr 660 665 670 Tyr Cys Ala Leu Trp Tyr Pro Asn Leu Trp Val Phe Gly Gly Gly Thr 675 680 685 Lys Leu Thr Val Leu Gly Ala Thr Pro Pro Glu Thr Gly Ala Glu Thr 690 695 700 Glu Ser Pro Gly Glu Thr Thr Thr Gly Gly Ser Ala Glu Ser Glu Pro Pro 705 710 715 720 Gly Glu Gly Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Ile Val Gln 725 730 735 Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 74 0 745 750 Asn Thr Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 755 760 765 Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr 770 775 780 Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser 785 790 795 800 Lys Asn Thr Val Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr 805 810 815 Ala Val Tyr Tyr Cys Val Arg His Glu Asn Phe Gly Asn Ser Tyr Val 820 825 83 Trp Phe Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 835 840 845 Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly 850 855 860 Glu Ala Ala Asn Ala Thr Ser Ala Gly Ala Thr Gly Pro Ser Ala Gly 865 870 875 880 Ser Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Gl u Gly Thr 885 890 895 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro 900 905 910 Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 915 920 925 Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr 930 935 940 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala 945 950 955 960 Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 965 970 975 Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser 980 985 990 Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala 995 1000 1005 Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 1010 1015 1020 Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 1025 1030 1035 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gl y Thr Ser 1040 1045 1050 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro 1055 1060 1065 Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 1070 1075 1080 Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 1085 1090 1095 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu 1100 1105 1110 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu Pro 1115 1120 1125 Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 1130 1135 1140 Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 1145 1150 1155 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro 1160 1165 1170 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala 1175 1180 1185 Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 1190 1195 1200 Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 1205 1210 1215 Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala Pro Gly Thr Ser 1220 1225 1230 Thr Glu Pro Ser Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro 1235 1240 1245 Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 1250 1255 1260 Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 1265 1270 1275 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro 1280 1285 1290 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro 1295 1300 1305 Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 1310 1315 1320 Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 1325 1330 1335 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu 1340 1345 1350 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala 1355 1360 1365 Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 1370 1375 1380 Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 1385 1390 1395 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro 1400 1405 1410 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser 1415 1420 1425 Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu 1430 1435 1440 Ser Gly Pro Gly Thr Ser T hr Glu Pro Ser Glu Gly Ser Ala Pro 1445 1450 1455 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu 1460 1465 1470 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala 1475 1480 1485 Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 1490 1495 1500 Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 1505 1510 1515 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro 1520 1525 1530 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala 1535 1540 1545 Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 1550 1555 1560 Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 1565 1570 1575 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro 1580 1585 1590 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Ser Thr Glu Pro 1595 1600 1605 Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 1610 1615 1620 Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 1625 1630 1635 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gl y Ser Glu 1640 1645 1650 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr 1655 1660 1665 Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 1670 1675 1680 Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 1685 1690 1695 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu 1700 1705 1710 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala 1715 1720 1725 Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 1730 1735 1740 Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 1745 1750 1755 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 1760 1765 1770 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser 1775 1780 1785 Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly 1790 1795 1800 Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 1805 1810 1815 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu 1820 1825 1830 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr 1835 1840 1845 Ser Gly Ser Thr Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr 1850 1855 1860 Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 1865 1870 1875 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr 1880 1885 1890 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly 1895 1900 1905 Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu 1910 1915 1920 Gly Ser Ala Pro Gly Thr Ala Thr Glu Ser Pro Glu Gly Ser Ala 1925 1930 1935 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr 1940 1945 1950 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Ala Glu 1955 1960 1965 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 1970 1975 1980 Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 1985 1990 1995 Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 2000 2005 2010 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Glu Ser 2015 2020 2025 Ala Ser 2030 <![CDATA[ <210> 29]]>
           <![CDATA[ <211> 1450]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 29]]>
          Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Ser Gly Thr Ser Glu Ser
          1 5 10 15
          Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly
                      20 25 30
          Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly
                  35 40 45
          Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser
              50 55 60
          Ala Thr Pro Glu Ser Gly Pro Gly Ser Thr Pro Ala Glu Ser Gly Ser
          65 70 75 80
          Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly
                          85 90 95
          Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly
                      100 105 110
          Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu
                  115 120 125
          Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
              130 135 140
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly
          145 150 155 160
          Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser
                          165 170 175
          Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
                      180 185 190
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser
                  195 200 205
          Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu
              210 215 220
          Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
          225 230 235 240
          Ser Glu Pro Ala Thr Ser Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly
                          245 250 255
          Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Thr Glu Gly
                      260 265 270
          Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
                  275 280 285
          Gly Ser Ala Pro Thr Thr Gly Arg Ala Thr Glu Ala Ala Asn Ala Thr
              290 295 300
          Pro Ala Gly Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
          305 310 315 320
          Thr Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
                          325 330 335
          Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ile
                      340 345 350
          Gly Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
                  355 360 365
          Ile Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser
              370 375 380
          Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln
          385 390 395 400
          Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ile Tyr Pro
                          405 410 415
          Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Ala Thr Pro
                      420 425 430
          Pro Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly Glu Thr Thr Gly Gly
                  435 440 445
          Ser Ala Glu Ser Glu Pro Pro Gly Glu Gly Glu Val Gln Leu Val Glu
              450 455 460
          Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys
          465 470 475 480
          Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr Thr Met Asp Trp Val Arg
                          485 490 495
          Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Asp Val Asn Pro Asn
                      500 505 510
          Ser Gly Gly Ser Ile Tyr Asn Gln Arg Phe Lys Gly Arg Phe Thr Leu
                  515 520 525
          Ser Val Asp Arg Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu
              530 535 540
          Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn Leu Gly Pro
          545 550 555 560
          Ser Phe Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
                          565 570 575
          Ser Gly Gly Gly Ser Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr
                      580 585 590
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly
                  595 600 605
          Ala Val Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly
              610 615 620
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly
          625 630 635 640
          Thr Pro Ala Arg Phe Ser Gly Ser Ser Leu Gly Gly Ser Ala Ala Leu
                          645 650 655
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala
                      660 665 670
          Leu Trp Tyr Ser Asn Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr
                  675 680 685
          Val Leu Gly Ala Thr Pro Pro Glu Thr Gly Ala Glu Thr Glu Ser Pro
              690 695 700
          Gly Glu Thr Thr Gly Gly Ser Ala Glu Ser Glu Pro Pro Gly Glu Gly
          705 710 715 720
          Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
                          725 730 735
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr
                      740 745 750
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
                  755 760 765
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp
              770 775 780
          Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
          785 790 795 800
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr
                          805 810 815
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe
                      820 825 830
          Ala Tyr Trp Gly Gly Gly Gly Thr Leu Val Thr Val Ser Ser Ser Gly Thr Ala
                  835 840 845
          Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Thr Glu Ala Ala
              850 855 860
          Asn Ala Thr Pro Ala Gly Leu Thr Gly Pro Thr Pro Glu Ser Gly Pro
          865 870 875 880
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala
                          885 890 895
          Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro
                      900 905 910
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro
                  915 920 925
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Ser Thr
              930 935 940
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu
          945 950 955 960
          Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
                          965 970 975
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Ser Thr
                      980 985 990
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu
                  995 1000 1005
          Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
              1010 1015 1020
          Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr
              1025 1030 1035
          Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala
              1040 1045 1050
          Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro
              1055 1060 1065
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
              1070 1075 1080
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr
              1085 1090 1095
          Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser
              1100 1105 1110
          Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr
              1115 1120 1125
          Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
              1130 1135 1140
          Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr
              1145 1150 1155
          Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu
              1160 1165 1170
          Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro
              1175 1180 1185
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
              1190 1195 1200
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser
              1205 1210 1215
          Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser
              1220 1225 1230
          Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu
              1235 1240 1245
          Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
              1250 1255 1260
          Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser
              1265 1270 1275
          Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser
              1280 1285 1290
          Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr
              1295 1300 1305
          Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
              1310 1315 1320
          Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr
              1325 1330 1335
          Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser
              1340 1345 1350
          Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro
              1355 1360 1365
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
              1370 1375 1380
          Pro Gly Ser Glu Ser Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser
              1385 1390 1395
          Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu
              1400 1405 1410
          Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu
              1415 1420 1425
          Gly Ser Ala Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
              1430 1435 1440
          Pro Gly Thr Ser Glu Ser Ala
              1445 1450
           <![CDATA[ <210> 30]]>
           <![CDATA[ <211> 2022]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 30]]> Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 1 5 10 15 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 20 25 30 Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 35 40 45 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 50 55 60 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 65 70 75 80 Glu Ser Gly Pro Gly Ser Glu Ser Ala Thr Ser Gly Ser Glu Thr Pro 85 90 95 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala 100 105 110 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 115 120 125 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Ser Ala Pro 130 135 140 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala 145 150 155 160 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu 165 170 175 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 180 185 190 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 195 200 205 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 210 215 220 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 225 230 235 240 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 245 250 255 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 260 265 270 Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 275 280 285 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 290 295 300 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 305 310 315 320 Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 325 330 335 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 340 345 350 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 355 360 365 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 370 375 380 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 385 390 395 400 Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 405 410 415 Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 420 425 430 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 435 440 445 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 450 455 460 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 465 470 475 480 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 485 490 495 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 500 505 510 Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 515 520 525 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala 530 535 540 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 545 550 555 560 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 565 570 575 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 580 585 590 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 595 600 605 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 610 615 620 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 625 630 635 640 Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 645 650 655 Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 660 665 670 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu 675 680 685 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr 690 695 700 Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Thr Glu Glu 705 710 715 720 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 725 730 735 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro 74 0 745 750 Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 755 760 765 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro 770 775 780 Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr 785 790 795 800 Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 805 810 815 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro 820 825 830 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 835 840 845 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 850 855 860 Thr Thr Ala Arg Ala Gly Ser Ala Glu Asn Leu Ser Pro Ser Gly Leu 865 870 875 880 Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr As p Ile Gln 885 890 895 Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 900 905 910 Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ile Gly Val Ala Trp 915 920 925 Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala 930 935 940 Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 945 950 955 960 Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 965 970 975 Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ile Tyr Pro Tyr Thr Phe Gly 980 985 990 Gln Gly Thr Lys Val Glu Ile Lys Gly Ala Thr Pro Pro Glu Thr Gly 995 1000 1005 Ala Glu Thr Glu Ser Pro Gly Glu Thr Thr Gly Gly Ser Ala Glu 1010 1015 1020 Ser Glu Pro Pro Gly Glu Gly Glu Val Gln Leu Val Glu Ser Gly 1025 1030 1035 Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Se r Cys Ala 1040 1045 1050 Ala Ser Gly Phe Thr Phe Thr Asp Tyr Thr Met Asp Trp Val Arg 1055 1060 1065 Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Asp Val Asn Pro 1070 1075 1080 Asn Ser Gly Tyr Ser Ile Gln Arg Phe Lys Gly Arg Phe 1085 1090 1095 Thr Leu Ser Val Asp Arg Ser Lys Asn Thr Leu Tyr Leu Gln Met 1100 1105 1110 Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 1115 1120 Asn Leu G Ser Phe Tyr Phe Asp Tyr Trp Gly Gly Gly Thr 1130 1135 1140 Leu Val Thr Val Ser Ser Ser Gly Gly Gly Ser Glu Leu Val Val Thr 1145 1150 1155 Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 1161 17065 Thr Cys Arg Ser Ser Asn Gly Ala Val Thr Ser Ser Asn Tyr Ala 1175 1180 1185 Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile 1190 1195 1200 Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe Ser 1205 1210 1215 Gly Ser Ser Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 1220 1225 1230 Gln Pro Glu Asp Glu Ala Val Tyr Tyr Cys Ala Leu Trp Tyr Pro 1235 1240 1245 Asn Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 1250 1255 1260 Ala Thr Pro Pro Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly Glu 1265 1270 1275 Thr Thr Gly Gly Ser Ala Glu Ser Glu Pro Pro Gly Glu Gly Glu 1280 1285 1290 Val Gln Leu Gln Glu Ser Gly Gly Gly Ile Val Gln Pro Gly Gly 1295 1300 1305 Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr 1310 1315 1320 Tyr Ala Met Asn Gln Trp A la Val Arg Gly Lys Gly Leu Glu 1325 1330 1335 Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr 1340 1345 1350 Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 1355 1360 Val Thr 1365 Ser Lys Leu Gln Met Asn Asn Leu Lys Thr Glu 1370 1375 1380 Asp Thr Ala Val Tyr Tyr Cys Val Arg His Glu Asn Phe Gly Asn 1385 1390 1395 Ser Tyr Val Ser Trp Phe Ala His Trp Gly Gln Gly Thr Leu Val 1500 1 Ser Ser Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr 1415 1420 1425 Thr Ala Arg Ala Gly Ser Ala Glu Asn Leu Ser Pro Ser Gly Leu 1430 1435 1440 Thr Gly Pro Glu Gly Ser A la Pro Gly Thr Ser Thr Glu Ser 1445 1450 1455 Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 1460 1465 1470 Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 1475 1480 1485 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 1490 1495 1500 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser 1505 1510 1515 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 1520 1525 1530 Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 1535 1540 1545 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala 1550 1555 1560 Gly Ser Pro Thr Ser Thr Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr 1565 1570 1575 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 1580 1585 1590 Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 1595 1600 1605 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 1610 1615 1620 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser 1625 1630 1635 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Gl u Gly Ser 1640 1645 1650 Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 1655 1660 1665 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala 1670 1675 1680 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser 1685 1690 1695 Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 1700 1705 1710 Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 1715 1720 1725 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 1730 1735 1740 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 1745 1750 1755 Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 1760 1765 1770 Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 1775 1780 1785 Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala 1790 1795 1800 Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro 1805 1810 1815 Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 1820 1825 1830 Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 1835 1840 1845 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 1850 1855 1860 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 1865 1870 1875 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 1880 1885 1890 Thr Pro Gly Thr Ser Glu Ser Ala Ser Pro Glu Ser Gly Pro Gly 1895 1900 1905 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala 1910 1915 1920 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr 1925 1930 1935 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Ser Gly Ser Glu 1940 1945 1950 Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 1955 1960 1965 Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala 1970 1975 1980 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser 1985 1990 1995 Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 2000 2005 2010 Gly Pro Gly Thr Ser Glu Ser Ala Thr 2015 2020 <![CDATA[ <210> 31]]>
           <![CDATA[ <211> 2312]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 31]]> Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 1 5 10 15 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 20 25 30 Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 35 40 45 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 50 55 60 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 65 70 75 80 Glu Ser Gly Pro Gly Ser Glu Ser Ala Thr Ser Gly Ser Glu Thr Pro 85 90 95 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala 100 105 110 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 115 120 125 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Ser Ala Pro 130 135 140 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala 145 150 155 160 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu 165 170 175 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 180 185 190 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 195 200 205 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 210 215 220 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 225 230 235 240 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 245 250 255 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 260 265 270 Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 275 280 285 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 290 295 300 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 305 310 315 320 Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 325 330 335 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 340 345 350 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 355 360 365 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 370 375 380 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 385 390 395 400 Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 405 410 415 Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 420 425 430 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 435 440 445 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 450 455 460 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 465 470 475 480 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 485 490 495 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 500 505 510 Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 515 520 525 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala 530 535 540 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 545 550 555 560 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 565 570 575 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 580 585 590 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 595 600 605 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 610 615 620 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 625 630 635 640 Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 645 650 655 Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 660 665 670 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu 675 680 685 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr 690 695 700 Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Thr Glu Glu 705 710 715 720 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 725 730 735 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro 74 0 745 750 Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 755 760 765 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro 770 775 780 Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr 785 790 795 800 Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 805 810 815 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro 820 825 830 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 835 840 845 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 850 855 860 Thr Thr Gly Arg Ala Gly Glu Ala Glu Gly Ala Thr Ser Ala Gly Ala 865 870 875 880 Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr As p Ile Gln 885 890 895 Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 900 905 910 Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ile Gly Val Ala Trp 915 920 925 Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala 930 935 940 Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 945 950 955 960 Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 965 970 975 Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ile Tyr Pro Tyr Thr Phe Gly 980 985 990 Gln Gly Thr Lys Val Glu Ile Lys Gly Ala Thr Pro Pro Glu Thr Gly 995 1000 1005 Ala Glu Thr Glu Ser Pro Gly Glu Thr Thr Gly Gly Ser Ala Glu 1010 1015 1020 Ser Glu Pro Pro Gly Glu Gly Glu Val Gln Leu Val Glu Ser Gly 1025 1030 1035 Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Se r Cys Ala 1040 1045 1050 Ala Ser Gly Phe Thr Phe Thr Asp Tyr Thr Met Asp Trp Val Arg 1055 1060 1065 Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Asp Val Asn Pro 1070 1075 1080 Asn Ser Gly Tyr Ser Ile Gln Arg Phe Lys Gly Arg Phe 1085 1090 1095 Thr Leu Ser Val Asp Arg Ser Lys Asn Thr Leu Tyr Leu Gln Met 1100 1105 1110 Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 1115 1120 Asn Leu G Ser Phe Tyr Phe Asp Tyr Trp Gly Gly Gly Thr 1130 1135 1140 Leu Val Thr Val Ser Ser Ser Gly Gly Gly Ser Glu Leu Val Val Thr 1145 1150 1155 Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 1161 17065 Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Ser Asn Tyr Ala 1175 1180 1185 Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile 1190 1195 1200 Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe Ser 1205 1210 1215 Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 1220 1225 1230 Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser 1235 1240 1245 Asn Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 1250 1255 1260 Ala Thr Pro Pro Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly Glu 1265 1270 1275 Thr Thr Gly Gly Ser Ala Glu Ser Glu Pro Pro Gly Glu Gly Glu 1280 1285 1290 Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1295 1300 1305 Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr 1310 1315 1320 Tyr Ala Met Asn Trp A Val G Gly Lys Gly Leu Glu 1325 1330 1335 Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr 1340 1345 1350 Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 1355 1360 ThAsyn 1365 Ser Ala Lys Leu Gln Met Asn Asn Leu Lys Thr Glu 1370 1375 1380 Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn 1385 1390 1395 Ser Tyr Val Ser Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 1400 4 Ser Ser Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr 1415 1420 1425 Thr Gly Arg Ala Gly Glu Ala Glu Gly Ala Thr Ser Ala Gly Ala 1430 1435 1440 Thr Gly Pro Pro Gly Ser P ro Ala Gly Ser Pro Thr Ser Thr Glu 1445 1450 1455 Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr 1460 1465 1470 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly 1475 1480 1485 Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu 1490 1495 1500 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 1505 1510 1515 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser 1520 1525 1530 Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala 1535 1540 1545 Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr 1550 1555 1560 Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 1565 1570 1575 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr 1580 1585 1590 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly 1595 1600 1605 Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu 1610 1615 1620 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 1625 1630 1635 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pr o Gly Thr 1640 1645 1650 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser 1655 1660 1665 Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 1670 1675 1680 Ser Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 1685 1690 1695 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr 1700 1705 1710 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser 1715 1720 1725 Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr 1730 1735 1740 Ser Thr Glu Glu Gly Thr Ser Ser Glu Ser Ala Thr Pro Glu Ser Gly 1745 1750 1755 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 1760 1765 1770 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu 1775 1780 1785 Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 1790 1795 1800 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 1805 1810 1815 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr 1820 1825 1830 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu 1835 1840 1845 Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 1850 1855 1860 Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 1865 1870 1875 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser 1880 1885 1890 Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 1895 1900 1905 Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 1910 1915 1920 Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 1925 1930 1935 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr 1940 1945 1950 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly 1955 1960 1965 Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr 1970 1975 1980 Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 1985 1990 1995 Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr 2000 2005 2010 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser 2015 2020 2025 Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 2030 2035 2040 Ser Glu Thr Pro Gly Thr S er Glu Ser Ala Thr Pro Glu Ser Gly 2045 2050 2055 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 2060 2065 2070 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu 2075 2080 2085 Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 2090 2095 2100 Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 2105 2110 2115 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 2120 2125 2130 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly 2135 2140 2145 Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr 2150 2155 2160 Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 2165 2170 2175 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr 2180 2185 2190 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser 2195 2200 2205 Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 2210 2215 2220 Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 2225 2230 2235 Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Gl u Gly Thr 2240 2245 2250 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Glu Ser Thr 2255 2260 2265 Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro Ala Thr Ser Gly 2270 2275 2280 Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 2285 2290 2295 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 2300 2305 2310 <![CDATA[ <210> 32]]>
           <![CDATA[ <211> 1751]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 32]]> Ala Ser Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Ser Gly Thr Ser 1 5 10 15 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Glu Thr Glu Pro Ser 20 25 30 Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 35 40 45 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 50 55 60 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Thr Pro Ala Glu Ser 65 70 75 80 Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 85 90 95 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro 100 105 110 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr 115 120 125 Pro Glu Ser Gly Pro Gly Glu Ser Pro Ala Thr Ser Gly Ser Thr Pro 130 135 140 Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro 145 150 155 160 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro 165 170 175 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 180 185 190 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 195 200 205 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr 210 215 220 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 225 230 235 240 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro 245 250 255 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser 260 265 270 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 275 280 285 Pro Gly Gly Ser Ala Pro Pro Thr Gly Arg Ser Gly Glu Gly Ala Asn 290 295 300 Ala Thr Pro Ser Gly Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr 305 310 315 320 Pro Gly Thr Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 325 330 335 Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val 340 345 350 Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 355 360 365 Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg 370 375 380 Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 385 390 395 400 Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr 405 410 415 Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Ala 420 425 430 Thr Pro Pro Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly Glu Thr Thr 435 440 445 Gly Gly Ser Ala Glu Ser Glu Pro Pro Gly Glu Gly Glu Val Gln Leu 450 455 460 Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 465 470 475 480 Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp 485 490 495 Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr 500 505 510 Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe 515 520 525 Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn 530 535 540 Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly 545 550 555 560 Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 565 570 575 Thr Val Ser Ser Gly Gly Gly Ser Glu Leu Val Val Thr Gln Glu Pro 580 585 590 Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser 595 600 605 Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Gln 610 615 620 Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Asn Lys Arg 625 630 635 640 Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys 645 650 655 Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr 660 665 670 Tyr Cys Ala Leu Trp Tyr Ser Asn Leu Trp Val Phe Gly Gly Gly Thr 675 680 685 Lys Leu Thr Val Leu Gly Ala Thr Pro Pro Glu Thr Gly Ala Glu Thr 690 695 700 Glu Ser Pro Gly Glu Thr Thr Thr Gly Gly Ser Ala Glu Ser Glu Pro Pro 705 710 715 720 Gly Glu Gly Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln 725 730 735 Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 74 0 745 750 Asn Thr Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 755 760 765 Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr 770 775 780 Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser 785 790 795 800 Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr 805 810 815 Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val 820 825 83 Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 835 840 845 Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Pro Thr Gly Arg Ser Gly 850 855 860 Glu Gly Ala Asn Ala Thr Pro Ser Gly Leu Thr Gly Pro Pro Gly Ser 865 870 875 880 Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Gl u Ser Ala 885 890 895 Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 900 905 910 Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr 915 920 925 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro 930 935 940 Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 945 950 955 960 Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser 965 970 975 Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser 980 985 990 Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 995 1000 1005 Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 1010 1015 1020 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala 1025 1030 1035 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Gl u Pro Ser 1040 1045 1050 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 1055 1060 1065 Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 1070 1075 1080 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 1085 1090 1095 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 1100 1105 1110 Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 1115 1120 1125 Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 1130 1135 1140 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu 1145 1150 1155 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro 1160 1165 1170 Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 1175 1180 1185 Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 1190 1195 1200 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 1205 1210 1215 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser 1220 1225 1230 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 1235 1240 1245 Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 1250 1255 1260 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 1265 1270 1275 Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro 1280 1285 1290 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 1295 1300 1305 Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 1310 1315 1320 Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu 1325 1330 1335 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 1340 1345 1350 Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 1355 1360 1365 Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 1370 1375 1380 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala 1385 1390 1395 Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro 1400 1405 1410 Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 1415 1420 1425 Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 1430 1435 1440 Thr Ser Thr Glu Pro Ser G lu Gly Ser Ala Pro Gly Thr Ser Glu 1445 1450 1455 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 1460 1465 1470 Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 1475 1480 1485 Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 1490 1495 1500 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 1505 1510 1515 Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro 1520 1525 1530 Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 1535 1540 1545 Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 1550 1555 1560 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala 1565 1570 1575 Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro 1580 1585 1590 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 1595 1600 1605 Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 1610 1615 1620 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Phe Thr Ala 1625 1630 1635 Asx Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly y Ser Glu 1640 1645 1650 Pro Ala Thr Ser Gly Pro Thr Glu Ser Gly Ser Glu Pro Ala Thr 1655 1660 1665 Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 1670 1675 1680 Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 1685 1690 1695 Gly Thr Glu Ser Thr Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu 1700 1705 1710 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala 1715 1720 1725 Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 1730 1735 1740 Ser Ala Pro Gly Glu Pro Glu Ala 1745 1750 <![CDATA[ <210> 33]]>
           <![CDATA[ <211> 1447]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 33]]>
          Ala Ser Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Ser Gly Thr Ser
          1 5 10 15
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
                      20 25 30
          Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  35 40 45
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
              50 55 60
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Thr Pro Ala Glu Ser
          65 70 75 80
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                          85 90 95
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro
                      100 105 110
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
                  115 120 125
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
              130 135 140
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro
          145 150 155 160
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro
                          165 170 175
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
                      180 185 190
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                  195 200 205
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr
              210 215 220
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
          225 230 235 240
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro
                          245 250 255
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser
                      260 265 270
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                  275 280 285
          Pro Gly Gly Ser Ala Pro Leu Gly Gly Arg Ala Asp Asn His Glu Pro
              290 295 300
          Pro Glu Leu Gly Ala Gly Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
          305 310 315 320
          Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
                          325 330 335
          Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala
                      340 345 350
          Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
                  355 360 365
          Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly
              370 375 380
          Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
          385 390 395 400
          Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro
                          405 410 415
          Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Ala Thr Pro Pro
                      420 425 430
          Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly Glu Thr Thr Gly Gly Ser
                  435 440 445
          Ala Glu Ser Glu Pro Pro Gly Glu Gly Glu Val Gln Leu Val Glu Ser
              450 455 460
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala
          465 470 475 480
          Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln
                          485 490 495
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn
                      500 505 510
          Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser
                  515 520 525
          Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg
              530 535 540
          Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly
          545 550 555 560
          Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
                          565 570 575
          Ser Gly Gly Gly Ser Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr
                      580 585 590
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser Ser Asn Gly
                  595 600 605
          Ala Val Thr Ser Ser Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly
              610 615 620
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly
          625 630 635 640
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu
                          645 650 655
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Val Tyr Tyr Cys Ala
                      660 665 670
          Leu Trp Tyr Pro Asn Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr
                  675 680 685
          Val Leu Gly Ala Thr Pro Pro Glu Thr Gly Ala Glu Thr Glu Ser Pro
              690 695 700
          Gly Glu Thr Thr Gly Gly Ser Ala Glu Ser Glu Pro Pro Gly Glu Gly
          705 710 715 720
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Ile Val Gln Pro Gly Gly
                          725 730 735
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr
                      740 745 750
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
                  755 760 765
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp
              770 775 780
          Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
          785 790 795 800
          Val Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr
                          805 810 815
          Tyr Cys Val Arg His Glu Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe
                      820 825 830
          Ala His Trp Gly Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Thr Ala
                  835 840 845
          Glu Ala Ala Ser Ala Ser Gly Leu Gly Gly Arg Ala Asp Asn His Glu
              850 855 860
          Pro Pro Glu Leu Gly Ala Gly Thr Pro Glu Ser Gly Pro Gly Thr Ser
          865 870 875 880
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro
                          885 890 895
          Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                      900 905 910
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
                  915 920 925
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
              930 935 940
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
          945 950 955 960
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                          965 970 975
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser
                      980 985 990
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                  995 1000 1005
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr
              1010 1015 1020
          Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser
              1025 1030 1035
          Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly
              1040 1045 1050
          Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
              1055 1060 1065
          Pro Gly Ser Glu Pro Ala Thr Ser Ser Gly Ser Glu Thr Pro Gly Thr
              1070 1075 1080
          Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu
              1085 1090 1095
          Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro
              1100 1105 1110
          Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
              1115 1120 1125
          Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser
              1130 1135 1140
          Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser
              1145 1150 1155
          Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu
              1160 1165 1170
          Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
              1175 1180 1185
          Pro Gly Ser Glu Pro Ala Thr Ser Ser Gly Ser Glu Thr Pro Gly Thr
              1190 1195 1200
          Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala
              1205 1210 1215
          Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro
              1220 1225 1230
          Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
              1235 1240 1245
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr
              1250 1255 1260
          Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala
              1265 1270 1275
          Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro
              1280 1285 1290
          Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
              1295 1300 1305
          Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr
              1310 1315 1320
          Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser
              1325 1330 1335
          Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro
              1340 1345 1350
          Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
              1355 1360 1365
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser
              1370 1375 1380
          Glu Ser Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly
              1385 1390 1395
          Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu
              1400 1405 1410
          Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
              1415 1420 1425
          Pro Gly Ser Glu Pro Ala Thr Ser Ser Gly Ser Glu Thr Pro Gly Thr
              1430 1435 1440
          Ser Glu Ser Ala
              1445
           <![CDATA[ <210> 34]]>
           <![CDATA[ <211> 1453]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 34]]>
          Ala Ser Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Ser Gly Thr Ser
          1 5 10 15
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
                      20 25 30
          Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  35 40 45
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
              50 55 60
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Thr Pro Ala Glu Ser
          65 70 75 80
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                          85 90 95
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro
                      100 105 110
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
                  115 120 125
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
              130 135 140
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro
          145 150 155 160
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro
                          165 170 175
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
                      180 185 190
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                  195 200 205
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr
              210 215 220
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
          225 230 235 240
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro
                          245 250 255
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser
                      260 265 270
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                  275 280 285
          Pro Gly Gly Ser Ala Pro Glu Ala Gly Arg Ser Ala Asn His Thr Pro
              290 295 300
          Ala Gly Leu Thr Gly Pro Ala Thr Ser Ser Gly Ser Glu Thr Pro Gly Thr
          305 310 315 320
          Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
                          325 330 335
          Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ile Gly
                      340 345 350
          Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
                  355 360 365
          Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly
              370 375 380
          Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
          385 390 395 400
          Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ile Tyr Pro Tyr
                          405 410 415
          Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Ala Thr Pro Pro
                      420 425 430
          Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly Glu Thr Thr Gly Gly Ser
                  435 440 445
          Ala Glu Ser Glu Pro Pro Gly Glu Gly Glu Val Gln Leu Val Glu Ser
              450 455 460
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala
          465 470 475 480
          Ala Ser Gly Phe Thr Phe Thr Asp Tyr Thr Met Asp Trp Val Arg Gln
                          485 490 495
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Asp Val Asn Pro Asn Ser
                      500 505 510
          Gly Gly Ser Ile Tyr Asn Gln Arg Phe Lys Gly Arg Phe Thr Leu Ser
                  515 520 525
          Val Asp Arg Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg
              530 535 540
          Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn Leu Gly Pro Ser
          545 550 555 560
          Phe Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                          565 570 575
          Gly Gly Gly Gly Ser Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr
                      580 585 590
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser Ser Asn Gly
                  595 600 605
          Ala Val Thr Ser Ser Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly
              610 615 620
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly
          625 630 635 640
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu
                          645 650 655
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Val Tyr Tyr Cys Ala
                      660 665 670
          Leu Trp Tyr Pro Asn Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr
                  675 680 685
          Val Leu Gly Ala Thr Pro Pro Glu Thr Gly Ala Glu Thr Glu Ser Pro
              690 695 700
          Gly Glu Thr Thr Gly Gly Ser Ala Glu Ser Glu Pro Pro Gly Glu Gly
          705 710 715 720
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Ile Val Gln Pro Gly Gly
                          725 730 735
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr
                      740 745 750
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
                  755 760 765
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp
              770 775 780
          Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
          785 790 795 800
          Val Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr
                          805 810 815
          Tyr Cys Val Arg His Glu Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe
                      820 825 830
          Ala His Trp Gly Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Thr Ala
                  835 840 845
          Glu Ala Ala Ser Ala Ser Gly Glu Ala Gly Arg Ser Ala Asn His Thr
              850 855 860
          Pro Ala Gly Leu Thr Gly Pro Pro Gly Ser Pro Ala Gly Ser Pro Thr
          865 870 875 880
          Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                          885 890 895
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu
                      900 905 910
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu
                  915 920 925
          Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
              930 935 940
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Ser Thr
          945 950 955 960
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu
                          965 970 975
          Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
                      980 985 990
          Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr
                  995 1000 1005
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
              1010 1015 1020
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu
              1025 1030 1035
          Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly
              1040 1045 1050
          Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu
              1055 1060 1065
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
              1070 1075 1080
          Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser
              1085 1090 1095
          Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly
              1100 1105 1110
          Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala
              1115 1120 1125
          Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
              1130 1135 1140
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser
              1145 1150 1155
          Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly
              1160 1165 1170
          Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu
              1175 1180 1185
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
              1190 1195 1200
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser
              1205 1210 1215
          Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
              1220 1225 1230
          Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu
              1235 1240 1245
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
              1250 1255 1260
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser
              1265 1270 1275
          Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly
              1280 1285 1290
          Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr
              1295 1300 1305
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
              1310 1315 1320
          Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser
              1325 1330 1335
          Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly
              1340 1345 1350
          Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro
              1355 1360 1365
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro
              1370 1375 1380
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser
              1385 1390 1395
          Ala Pro Gly Thr Glu Ser Thr Pro Ser Glu Gly Ser Ala Pro Gly
              1400 1405 1410
          Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu
              1415 1420 1425
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
              1430 1435 1440
          Glu Gly Ser Ala Pro Gly Glu Pro Glu Ala
              1445 1450
           <![CDATA[ <210> 35]]>
           <![CDATA[ <211> 1452]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 35]]>
          Ala Ser Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Ser Gly Thr Ser
          1 5 10 15
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
                      20 25 30
          Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  35 40 45
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
              50 55 60
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Thr Pro Ala Glu Ser
          65 70 75 80
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                          85 90 95
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro
                      100 105 110
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
                  115 120 125
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
              130 135 140
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro
          145 150 155 160
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro
                          165 170 175
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
                      180 185 190
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                  195 200 205
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr
              210 215 220
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
          225 230 235 240
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro
                          245 250 255
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser
                      260 265 270
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                  275 280 285
          Pro Gly Gly Ser Ala Pro Gly Ala Gly Arg Thr Asp Asn His Glu Pro
              290 295 300
          Leu Glu Leu Gly Ala Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
          305 310 315 320
          Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
                          325 330 335
          Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Asp Val Ser Ile Gly
                      340 345 350
          Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
                  355 360 365
          Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ala Arg Phe Ser Gly
              370 375 380
          Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
          385 390 395 400
          Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Ile Tyr Pro Tyr
                          405 410 415
          Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Ala Thr Pro Pro
                      420 425 430
          Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly Glu Thr Thr Gly Gly Ser
                  435 440 445
          Ala Glu Ser Glu Pro Pro Gly Glu Gly Gln Val Gln Leu Val Gln Ser
              450 455 460
          Gly Val Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys
          465 470 475 480
          Ala Ser Gly Phe Thr Phe Thr Asp Tyr Thr Met Asp Trp Val Arg Gln
                          485 490 495
          Ala Pro Gly Gln Gly Leu Glu Trp Met Ala Asp Val Asn Pro Asn Ser
                      500 505 510
          Gly Gly Ser Ile Tyr Asn Gln Arg Phe Lys Gly Arg Val Thr Leu Thr
                  515 520 525
          Thr Asp Ser Ser Thr Thr Thr Ala Tyr Met Glu Leu Lys Ser Leu Gln
              530 535 540
          Phe Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn Leu Gly Pro Ser
          545 550 555 560
          Phe Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                          565 570 575
          Gly Gly Gly Ser Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val
                      580 585 590
          Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala
                  595 600 605
          Val Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln
              610 615 620
          Ala Pro Arg Gly Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr
          625 630 635 640
          Pro Ala Arg Phe Ser Gly Ser Ser Leu Gly Gly Ser Ala Ala Leu Thr
                          645 650 655
          Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu
                      660 665 670
          Trp Tyr Ser Asn Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val
                  675 680 685
          Leu Gly Ala Thr Pro Pro Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly
              690 695 700
          Glu Thr Thr Gly Gly Ser Ala Glu Ser Glu Pro Pro Gly Glu Gly Glu
          705 710 715 720
          Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser
                          725 730 735
          Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr Ala
                      740 745 750
          Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala
                  755 760 765
          Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser
              770 775 780
          Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala
          785 790 795 800
          Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr
                          805 810 815
          Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala
                      820 825 830
          Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Thr Ala Glu
                  835 840 845
          Ala Ala Ser Ala Ser Gly Gly Ala Gly Arg Thr Asp Asn His Glu Pro
              850 855 860
          Leu Glu Leu Gly Ala Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser
          865 870 875 880
          Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly
                          885 890 895
          Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser
                      900 905 910
          Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly
                  915 920 925
          Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
              930 935 940
          Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu
          945 950 955 960
          Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly
                          965 970 975
          Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
                      980 985 990
          Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu
                  995 1000 1005
          Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro
              1010 1015 1020
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
              1025 1030 1035
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser
              1040 1045 1050
          Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser
              1055 1060 1065
          Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu
              1070 1075 1080
          Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
              1085 1090 1095
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser
              1100 1105 1110
          Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly
              1115 1120 1125
          Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro
              1130 1135 1140
          Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
              1145 1150 1155
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser
              1160 1165 1170
          Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser
              1175 1180 1185
          Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly
              1190 1195 1200
          Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
              1205 1210 1215
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser
              1220 1225 1230
          Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser
              1235 1240 1245
          Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly
              1250 1255 1260
          Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
              1265 1270 1275
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser
              1280 1285 1290
          Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu
              1295 1300 1305
          Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro
              1310 1315 1320
          Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
              1325 1330 1335
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser
              1340 1345 1350
          Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala
              1355 1360 1365
          Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr
              1370 1375 1380
          Ser Thr Glu Glu Gly Thr Ser Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
              1385 1390 1395
          Pro Gly Thr Glu Ser Thr Pro Ser Glu Gly Ser Ala Pro Gly Ser
              1400 1405 1410
          Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser
              1415 1420 1425
          Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu
              1430 1435 1440
          Gly Ser Ala Pro Gly Glu Pro Glu Ala
              1445 1450
           <![CDATA[ <210> 36]]>
           <![CDATA[ <211> 2593]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 36]]> Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 1 5 10 15 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 20 25 30 Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 35 40 45 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 50 55 60 Glu Pro Ser Glu Gly Ser Ala Pro Ala Thr Ser Glu Ser Ala Thr Pro 65 70 75 80 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 85 90 95 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala 100 105 110 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Ser Pro 115 120 125 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Ser Ala Pro 130 135 140 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala 145 150 155 160 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu 165 170 175 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 180 185 190 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 195 200 205 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 210 215 220 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 225 230 235 240 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 245 250 255 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 260 265 270 Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 275 280 285 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 290 295 300 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 305 310 315 320 Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 325 330 335 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 340 345 350 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 355 360 365 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 370 375 380 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 385 390 395 400 Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 405 410 415 Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 420 425 430 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 435 440 445 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 450 455 460 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 465 470 475 480 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 485 490 495 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 500 505 510 Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 515 520 525 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala 530 535 540 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 545 550 555 560 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 565 570 575 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 580 585 590 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 595 600 605 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 610 615 620 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 625 630 635 640 Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 645 650 655 Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 660 665 670 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu 675 680 685 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr 690 695 700 Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Thr Glu Glu 705 710 715 720 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 725 730 735 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro 74 0 745 750 Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 755 760 765 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro 770 775 780 Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr 785 790 795 800 Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 805 810 815 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro 820 825 830 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 835 840 845 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 850 855 860 Ala Ser Gly Arg Ala Ala Asn Glu Thr Pro Pro Gly Leu Thr Gly Ala 865 870 875 880 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Glu Ile Val Le u Thr Gln 885 890 895 Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 900 905 910 Cys Lys Ala Ser Gln Asp Val Ser Ile Gly Val Ala Trp Tyr Gln Gln 915 920 925 Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Ser Ala Ser Tyr Arg 930 935 940 Tyr Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 945 950 955 960 Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr 965 970 975 Tyr Cys Gln Gln Tyr Tyr Ile Tyr Pro Tyr Thr Phe Gly Gln Gly Thr 980 985 990 Lys Val Glu Ile Lys Gly Ala Thr Pro Pro Glu Thr Gly Ala Glu Thr 995 1000 1005 Glu Ser Pro Gly Glu Thr Thr Thr Gly Gly Ser Ala Glu Ser Glu Pro 1010 1015 1020 Pro Gly Glu Gly Gln Val Gln Leu Val Gln Ser Gly Val Glu Val 1025 1030 1035 Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Al a Ser Gly 1040 1045 1050 Phe Thr Phe Thr Asp Tyr Thr Met Asp Trp Val Arg Gln Ala Pro 1055 1060 1065 Gly Gln Gly Leu Glu Trp Met Ala Asp Val Asn Pro Asn Ser Gly 1070 1075 1080 Gly Ser Phe Gln Tyr Asn Lys Gly Arg Val Thr Leu Thr 1085 1090 1095 Thr Asp Ser Ser Thr Thr Thr Ala Tyr Met Glu Leu Lys Ser Leu 1100 1105 1110 Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn Leu Gly 1115 1120 Phe Tyr Pro Ser Phe Asp Tyr Trp Gly Gly Gly Gly Thr Leu Val Thr 1130 1135 1140 Val Ser Ser Gly Gly Gly Gly Ser Glu Leu Val Thr Gln Glu Pro 1145 1150 1155 Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Arg 1160 1165 1 Ser Ser Asn Gly Ala Val Thr Ser Ser Ser Asn Tyr Ala Asn Trp Val 1175 1180 1185 Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr 1190 1195 1200 Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Ser 1205 1210 1215 Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu 1220 1225 1230 Asp Glu Ala Val Tyr Tyr Cys Ala Leu Trp Tyr Pro Asn Leu Trp 1235 1240 1245 Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ala Thr Pro 1250 1255 1260 Pro Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly Glu Thr Thr Gly 1265 1270 1275 Gly Ser Ala Glu Ser Glu Pro Pro Gly Glu Gly Glu Val Gln Leu 1280 1285 1290 Gln Glu Ser Gly Gly Gly Ile Val Gln Pro Gly Gly Ser Leu Lys 1295 1300 1305 Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr Ala Met 1310 1315 1320 Asn Trp Val Argly Gln Gla Pro G Leu Glu Trp Val Ala 1325 1330 1335 Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 1340 1345 1350 Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn 1355 1360 Val Tyr Tyr Tyr Ala Asp 1355 1360 Val Tyr Tyr Tyr M Leu Thr G Asn Asn Leu Lys Thr Glu Asp Thr Ala 1370 1375 1380 Val Tyr Tyr Cys Val Arg His Glu Asn Phe Gly Asn Ser Tyr Val 1385 1390 1395 Ser Trp Phe Ala His Trp Gly Gly Gly Thr Leu Val S5 Thr Val Ser 1400 G1400 41 14 Thr Ala Glu Ala Ala Ser Ala Ser Gly Ala Ser Gly Arg 1415 1420 1425 Ala Ala Asn Glu Thr Pro Pro Gly Leu Thr Gly Ala Ser Ala Gly 1430 1435 1440 Ser Pro Gly Ser Pro Ala G ly Ser Pro Thr Ser Thr Glu Glu Gly 1445 1450 1455 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 1460 1465 1470 Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro 1475 1480 1485 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 1490 1495 1500 Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 1505 1510 1515 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 1520 1525 1530 Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser 1535 1540 1545 Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 1550 1555 1560 Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 1565 1570 1575 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 1580 1585 1590 Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro 1595 1600 1605 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 1610 1615 1620 Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 1625 1630 1635 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Th r Ser Thr 1640 1645 1650 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 1655 1660 1665 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 1670 1675 1680 Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 1685 1690 1695 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 1700 1705 1710 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr 1715 1720 1725 Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 1730 1735 1740 Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 1745 1750 1755 Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu 1760 1765 1770 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 1775 1780 1785 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 1790 1795 1800 Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 1805 1810 1815 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 1820 1825 1830 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser 1835 1840 1845 Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 1850 1855 1860 Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 1865 1870 1875 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 1880 1885 1890 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 1895 1900 1905 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 1910 1915 1920 Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 1925 1930 1935 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 1940 1945 1950 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro 1955 1960 1965 Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 1970 1975 1980 Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 1985 1990 1995 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 2000 2005 2010 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 2015 2020 2025 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 2030 2035 2040 Thr Pro Gly Thr Ser Glu S er Ala Thr Pro Glu Ser Gly Pro Gly 2045 2050 2055 Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu 2060 2065 2070 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 2075 2080 2085 Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 2090 2095 2100 Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 2105 2110 2115 Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu 2120 2125 2130 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro 2135 2140 2145 Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 2150 2155 2160 Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 2165 2170 2175 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu 2180 2185 2190 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr 2195 2200 2205 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 2210 2215 2220 Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 2225 2230 2235 Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Th r Ser Thr 2240 2245 2250 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser 2255 2260 2265 Glu Gly Ser Ala Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 2270 2275 2280 Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 2285 2290 2295 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala 2300 2305 2310 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr 2315 2320 2325 Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 2330 2335 2340 Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 2345 2350 2355 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 2360 2365 2370 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 2375 2380 2385 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 2390 2395 2400 Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Thr Glu Thr Pro 2405 2410 2415 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 2420 2425 2430 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro 2435 2440 2445 Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Ser Thr Glu Pro Ser Glu Gly 2450 2455 2460 Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 2465 2470 2475 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ala 2480 2485 2490 Thr Glu Ser Pro Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala 2495 2500 2505 Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 2510 2515 2520 Ser Ala Pro Gly Thr Ser Ala Glu Ser Ala Thr Pro Glu Ser Gly 2525 2530 2535 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 2540 2545 2550 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu 2555 2560 2565 Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 2570 2575 2580 Glu Ser Gly Pro Gly Thr Glu Ser Ala Ser 2585 2590 <![CDATA[ <210> 37]]>
           <![CDATA[ <211> 2881]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 37]]> Ser Ala Gly Ser Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 1 5 10 15 Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 20 25 30 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro 35 40 45 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 50 55 60 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 65 70 75 80 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Thr Pro Ala Glu Ser 85 90 95 Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 100 105 110 Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 115 120 125 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 130 135 140 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 145 150 155 160 Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 165 170 175 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser 180 185 190 Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 195 200 205 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 210 215 220 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 225 230 235 240 Gly Ser Thr Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 245 250 255 Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr 260 265 270 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala 275 280 285 Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 290 295 300 Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser 305 310 315 320 Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala 325 330 335 Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 340 345 350 Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr 355 360 365 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro 370 375 380 Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 385 390 395 400 Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser 405 410 415 Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro 420 425 430 Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 435 440 445 Gly Pro Gly Ser Glu Pro Ala Thr Ser Ser Gly Ser Glu Thr Pro Gly Thr 450 455 460 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr 465 470 475 480 Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 485 490 495 Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr 500 505 510 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser 515 520 525 Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 530 535 540 Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr 545 550 555 560 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro 565 570 575 Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 580 585 590 Gly Pro Gly Ser Glu Pro Ala Thr Ser Ser Gly Ser Glu Thr Pro Gly Thr 595 600 605 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr 610 615 620 Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 625 630 635 640 Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser 645 650 655 Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala 660 665 670 Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 675 680 685 Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser 690 695 700 Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser 705 710 715 720 Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 725 730 735 Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr 74 0 745 750 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala 755 760 765 Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 770 775 780 Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser 785 790 795 800 Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro 805 810 815 Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 820 825 830 Ala Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 835 840 845 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro 850 855 860 Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 865 870 875 880 Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pr o Gly Thr 885 890 895 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser 900 905 910 Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 915 920 925 Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr 930 935 940 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr 945 950 955 960 Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 965 970 975 Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr 980 985 990 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro 995 1000 1005 Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 1010 1015 1020 Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 1025 1030 1035 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gl y Thr Ser 1040 1045 1050 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala 1055 1060 1065 Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 1070 1075 1080 Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 1085 1090 1095 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 1100 1105 1110 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro 1115 1120 1125 Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 1130 1135 1140 Ser Gly Pro Gly Thr Glu Ser Ala Ser Glu Ser Gly Arg Ala Ala 1145 1150 1155 Asn Thr Gly Pro Pro Thr Leu Thr Ala Pro Ala Thr Ser Gly Ser 1160 1165 1170 Glu Thr Pro Gly Thr Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 1175 1180 1185 Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala 1190 1195 1200 Ser Gln Asp Val Ser Ile Gly Val Ala Trp Tyr Gln Gln Lys Pro 1205 1210 1215 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr 1220 1225 1230 Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 1235 1240 1245 Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 1250 1255 1260 Tyr Tyr Cys Gln Gln Tyr Tyr Ile Tyr Pro Tyr Thr Phe Gly Gln 1265 1270 1275 Gly Thr Lys Val Glu Ile Lys Gly Ala Thr Pro Pro Glu Thr Gly 1280 1285 1290 Ala Glu Thr Glu Ser Pro Gly Glu Thr Thr Gly Gly Ser Ala Glu 1295 1300 1305 Ser Glu Pro Pro Gly Glu Gly Glu Val Gln Leu Val Glu Ser Gly 1310 1315 1320 Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 1325 1330 1335 Ala Ser Gly Phe Thr Phe Thr Asp Tyr Thr Met Asp Trp Val Arg 1340 1345 1350 Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Asp Val Asn Pro 1355 1360 1365 Asn Serle I Gly G Tyr Asn Gln Arg Phe Lys Gly Arg Phe 1370 1375 1380 Thr Leu Ser Val Asp Arg Ser Lys Asn Thr Leu Tyr Leu Gln Met 1385 1390 1395 Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 1400 410 140 Gly Pro Ser Phe Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 1415 1420 1425 Leu Val Thr Val Ser Ser Gly Gly Gly Ser Glu Leu Val Val Thr 1430 1435 1440 Gln Glu Pro Ser Leu Thr V al Ser Pro Gly Gly Thr Val Thr Leu 1445 1450 1455 Thr Cys Arg Ser Ser Asn Gly Ala Val Thr Ser Ser Asn Tyr Ala 1460 1465 1470 Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile 1475 1580 Gly Gly 148 Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe Ser 1490 1495 1500 Gly Ser Ser Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 1505 1510 1515 Gln Pro Glu Asp Glu Ala Val Tyr Tyr Cys Ala Leu Trp Tyr Pro 1520 1525 1530 Asn Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 1535 1540 1545 Ala Thr Pro Pro Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly Glu 1550 1555 1560 Thr Thr Gly Gly Ser Ala Glu Ser Glu Pro Pro Gly Glu Gly Glu 1565 1570 1575 Val Gln Leu Gln Glu Ser Gly Gly Gly Ile Val Gln Pro Gly Gly 1580 1585 1590 Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr 1595 1600 1605 Tyr Ala Val Met Arg Asn Gl Trp Ala Pro Gly Lys Gly Leu Glu 1610 1615 1620 Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr 1625 1630 1635 Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Ar g Asp Asp 1640 1645 1650 Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu 1655 1660 1665 Asp Thr Ala Val Tyr Tyr Cys Val Arg His Glu Asn Phe Gly Asn 1670 1675 1680 Serla Hp A Tr Val Ser Trp Gly Gln Gly Thr Leu Val 1685 1690 1695 Thr Val Ser Ser Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Glu 1700 1705 1710 Ser Gly Arg Ala Ala Asn Thr Gly Pro Thr Leu Thr Ala Pro 1715 1720 1725 Ser Ala Gly Ser Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 1730 1735 1740 Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 1745 1750 1755 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala 1760 1765 1770 Gly Ser Pro Thr Ser Thr Glu Glu Glu Gly Thr Ser Thr Glu Pro Ser 1775 1780 1785 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 1790 1795 1800 Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 1805 1810 1815 Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro 1820 1825 1830 Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro 1835 1840 1845 Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 1850 1855 1860 Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 1865 1870 1875 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala 1880 1885 1890 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser 1895 1900 1905 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 1910 1915 1920 Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 1925 1930 1935 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 1940 1945 1950 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 1955 1960 1965 Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 1970 1975 1980 Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 1985 1990 1995 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu 2000 2005 2010 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro 2015 2020 2025 Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 2030 2035 2040 Gly Pro Gly Ser Glu Pro A la Thr Ser Gly Ser Glu Thr Pro Gly 2045 2050 2055 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 2060 2065 2070 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser 2075 2080 2085 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 2090 2095 2100 Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 2105 2110 2115 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 2120 2125 2130 Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro 2135 2140 2145 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 2150 2155 2160 Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 2165 2170 2175 Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu 2180 2185 2190 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 2195 2200 2205 Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 2210 2215 2220 Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 2225 2230 2235 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Se r Pro Ala 2240 2245 2250 Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro 2255 2260 2265 Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 2270 2275 2280 Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 2285 2290 2295 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 2300 2305 2310 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 2315 2320 2325 Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 2330 2335 2340 Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 2345 2350 2355 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 2360 2365 2370 Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Ala Gly Ser Pro 2375 2380 2385 Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 2390 2395 2400 Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 2405 2410 2415 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala 2420 2425 2430 Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro 2435 2440 2445 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 2450 2455 2460 Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 2465 2470 2475 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu 2480 2485 2490 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 2495 2500 2505 Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 2510 2515 2520 Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 2525 2530 2535 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 2540 2545 2550 Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro Ala Thr Ser 2555 2560 2565 Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 2570 2575 2580 Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 2585 2590 2595 Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 2600 2605 2610 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 2615 2620 2625 Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 2630 2635 2640 Glu Glu Gly Thr Ser Thr G lu Pro Ser Glu Gly Ser Ala Pro Gly 2645 2650 2655 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 2660 2665 2670 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 2675 2680 2685 Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Thr 2690 2695 2700 Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Ser Glu Glu 2705 2710 2715 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 2720 2725 2730 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro 2735 2740 2745 Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 2750 2755 2760 Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 2765 2770 2775 Gly Thr Ala Thr Glu Ser Pro Glu Gly Ser Ala Pro Gly Thr Ser 2780 2785 2790 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro 2795 2800 2805 Ser Glu Gly Ser Ala Pro Gly Thr Ser Ala Glu Ser Ala Thr Pro 2810 2815 2820 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 2825 2830 2835 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pr o Gly Thr 2840 2845 2850 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser 2855 2860 2865 Ala Thr Pro Glu Ser Gly Pro Gly Thr Glu Ser Ala Ser 2870 2875 2880 <![CDATA[ <210> 38]]>
           <![CDATA[ <211> 1446]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 38]]>
          Ala Ser Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Ser Gly Thr Ser
          1 5 10 15
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Glu Thr Glu Pro Ser
                      20 25 30
          Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  35 40 45
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
              50 55 60
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Thr Pro Ala Glu Ser
          65 70 75 80
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                          85 90 95
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro
                      100 105 110
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
                  115 120 125
          Pro Glu Ser Gly Pro Gly Glu Ser Pro Ala Thr Ser Gly Ser Thr Pro
              130 135 140
          Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro
          145 150 155 160
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro
                          165 170 175
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
                      180 185 190
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                  195 200 205
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr
              210 215 220
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
          225 230 235 240
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro
                          245 250 255
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser
                      260 265 270
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                  275 280 285
          Pro Gly Gly Ser Ala Pro Ala Ser Gly Arg Gly Thr Asn Ala Gly Pro
              290 295 300
          Ala Gly Leu Thr Gly Pro Ala Thr Ser Ser Gly Ser Glu Thr Pro Gly Thr
          305 310 315 320
          Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
                          325 330 335
          Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Asp Val Ser Ile Gly
                      340 345 350
          Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
                  355 360 365
          Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ala Arg Phe Ser Gly
              370 375 380
          Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
          385 390 395 400
          Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Ile Tyr Pro Tyr
                          405 410 415
          Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Ala Thr Pro Pro
                      420 425 430
          Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly Glu Thr Thr Gly Gly Ser
                  435 440 445
          Ala Glu Ser Glu Pro Pro Gly Glu Gly Gln Val Gln Leu Val Gln Ser
              450 455 460
          Gly Val Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys
          465 470 475 480
          Ala Ser Gly Phe Thr Phe Thr Asp Tyr Thr Met Asp Trp Val Arg Gln
                          485 490 495
          Ala Pro Gly Gln Gly Leu Glu Trp Met Ala Asp Val Asn Pro Asn Ser
                      500 505 510
          Gly Gly Ser Ile Tyr Asn Gln Arg Phe Lys Gly Arg Val Thr Leu Thr
                  515 520 525
          Thr Asp Ser Ser Thr Thr Thr Ala Tyr Met Glu Leu Lys Ser Leu Gln
              530 535 540
          Phe Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn Leu Gly Pro Ser
          545 550 555 560
          Phe Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                          565 570 575
          Gly Gly Gly Ser Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val
                      580 585 590
          Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala
                  595 600 605
          Val Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln
              610 615 620
          Ala Pro Arg Gly Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr
          625 630 635 640
          Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr
                          645 650 655
          Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu
                      660 665 670
          Trp Tyr Ser Asn Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val
                  675 680 685
          Leu Gly Ala Thr Pro Pro Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly
              690 695 700
          Glu Thr Thr Gly Gly Ser Ala Glu Ser Glu Pro Pro Gly Glu Gly Glu
          705 710 715 720
          Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser
                          725 730 735
          Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr Ala
                      740 745 750
          Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala
                  755 760 765
          Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser
              770 775 780
          Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala
          785 790 795 800
          Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr
                          805 810 815
          Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala
                      820 825 830
          Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Thr Ala Glu
                  835 840 845
          Ala Ala Ser Ala Ser Gly Ala Ser Gly Arg Gly Thr Asn Ala Gly Pro
              850 855 860
          Ala Gly Leu Thr Gly Pro Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu
          865 870 875 880
          Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu
                          885 890 895
          Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
                      900 905 910
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala
                  915 920 925
          Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly
              930 935 940
          Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
          945 950 955 960
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser
                          965 970 975
          Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser
                      980 985 990
          Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly
                  995 1000 1005
          Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu
              1010 1015 1020
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
              1025 1030 1035
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser
              1040 1045 1050
          Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
              1055 1060 1065
          Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr
              1070 1075 1080
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser
              1085 1090 1095
          Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr
              1100 1105 1110
          Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
              1115 1120 1125
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro
              1130 1135 1140
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr
              1145 1150 1155
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu
              1160 1165 1170
          Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly
              1175 1180 1185
          Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu
              1190 1195 1200
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro
              1205 1210 1215
          Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr
              1220 1225 1230
          Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly
              1235 1240 1245
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr
              1250 1255 1260
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
              1265 1270 1275
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu
              1280 1285 1290
          Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly
              1295 1300 1305
          Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu
              1310 1315 1320
          Ser Ala Ser Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
              1325 1330 1335
          Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr
              1340 1345 1350
          Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly
              1355 1360 1365
          Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu
              1370 1375 1380
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro
              1385 1390 1395
          Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr
              1400 1405 1410
          Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
              1415 1420 1425
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu
              1430 1435 1440
          Ser Ala Thr
              1445
           <![CDATA[ <210> 39]]>
           <![CDATA[ <211> 2024]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 39]]> Ala Ser Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Ser Gly Thr Ser 1 5 10 15 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 20 25 30 Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 35 40 45 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 50 55 60 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Thr Pro Ala Glu Ser 65 70 75 80 Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 85 90 95 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro 100 105 110 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr 115 120 125 Pro Glu Ser Gly Pro Gly Glu Glu Pro Ala Thr Ser Gly Ser Thr Pro 130 135 140 Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro 145 150 155 160 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro 165 170 175 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 180 185 190 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 195 200 205 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr 210 215 220 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 225 230 235 240 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro 245 250 255 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser 260 265 270 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 275 280 285 Pro Gly Gly Ser Ala Pro Glu Ala Gly Arg Ser Ala Asn His Thr Pro 290 295 300 Ala Gly Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 305 310 315 320 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 325 330 335 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 340 345 350 Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 355 360 365 Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 370 375 380 Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Leu Gln Pro 385 390 395 400 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 405 410 415 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Ala Thr Pro Pro 420 425 430 Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly Glu Thr Thr Gly Gly Ser 435 440 445 Ala Glu Ser Glu Pro Pro Gly Glu Gly Glu Val Gln Leu Val Glu Ser 450 455 460 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 465 470 475 480 Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln 485 490 495 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn 500 505 510 Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 515 520 525 Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg 530 535 540 Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly 545 550 555 560 Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 565 570 575 Ser Gly Gly Gly Ser Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr 580 585 590 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser Ser Asn Gly 595 600 605 Ala Val Thr Ser Ser Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly 610 615 620 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly 625 630 635 640 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 645 650 655 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Val Tyr Tyr Cys Ala 660 665 670 Leu Trp Tyr Pro Asn Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 675 680 685 Val Leu Gly Ala Thr Pro Pro Glu Thr Gly Ala Glu Thr Glu Ser Pro 690 695 700 Gly Glu Thr Thr Gly Gly Ser Ala Glu Ser Glu Pro Pro Gly Glu Gly 705 710 715 720 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Ile Val Gln Pro Gly Gly 725 730 735 Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 74 0 745 750 Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 755 760 765 Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 770 775 780 Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 785 790 795 800 Val Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 805 810 815 Tyr Cys Val Arg His Glu Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 823 0 Ala 8 His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Thr Ala 835 840 845 Glu Ala Ala Ser Ala Ser Gly Glu Ala Gly Arg Ser Ala Asn His Thr 850 855 860 Pro Ala Gly Leu Thr Gly Pro Ser Ala Gly Ser Pro Gly Ser Pro Ala 865 870 875 880 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Al a Thr Pro 885 890 895 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 900 905 910 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr 915 920 925 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 930 935 940 Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 945 950 955 960 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro 965 970 975 Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr 980 985 990 Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 995 1000 1005 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 1010 1015 1020 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser 1025 1030 1035 Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Se r Glu Gly 1040 1045 1050 Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 1055 1060 1065 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 1070 1075 1080 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala 1085 1090 1095 Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 1100 1105 1110 Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 1115 1120 1125 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 1130 1135 1140 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala 1145 1150 1155 Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 1160 1165 1170 Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 1175 1180 1185 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 1190 1195 1200 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro 1205 1210 1215 Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 1220 1225 1230 Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 1235 1240 1245 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 1250 1255 1260 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro 1265 1270 1275 Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 1280 1285 1290 Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 1295 1300 1305 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu 1310 1315 1320 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala 1325 1330 1335 Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 1340 1345 1350 Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 1355 1360 1365 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 1370 1375 1380 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser 1385 1390 1395 Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser 1400 1405 1410 Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 1415 1420 1425 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 1430 1435 1440 Thr Glu Pro Ser Glu Gly S er Ala Pro Gly Thr Ser Glu Ser Ala 1445 1450 1455 Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 1460 1465 1470 Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 1475 1480 1485 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 1490 1495 1500 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro 1505 1510 1515 Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 1520 1525 1530 Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 1535 1540 1545 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 1550 1555 1560 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser 1565 1570 1575 Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser 1580 1585 1590 Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 1595 1600 1605 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 1610 1615 1620 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala 1625 1630 1635 Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Se r Gly Ser 1640 1645 1650 Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 1655 1660 1665 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 1670 1675 1680 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro 1685 1690 1695 Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 1700 1705 1710 Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 1715 1720 1725 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro 1730 1735 1740 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala 1745 1750 1755 Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 1760 1765 1770 Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 1775 1780 1785 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 1790 1795 1800 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala 1805 1810 1815 Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 1820 1825 1830 Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Thr Glu Thr 1835 1840 1845 Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr 1850 1855 1860 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu 1865 1870 1875 Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 1880 1885 1890 Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 1895 1900 1905 Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr 1910 1915 1920 Ala Thr Glu Ser Pro Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser 1925 1930 1935 Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 1940 1945 1950 Gly Ser Ala Pro Gly Thr Ser Ala Glu Ser Ala Thr Pro Glu Ser 1955 1960 1965 Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 1970 1975 1980 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 1985 1990 1995 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 2000 2005 2010 Pro Glu Ser Gly Pro Gly Thr Glu Ser Ala Ser 2015 2020 <![CDATA[ <210> 40]]>
           <![CDATA[ <211> 1744]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 40]]> Ala Ser Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Ser Gly Thr Ser 1 5 10 15 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 20 25 30 Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 35 40 45 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 50 55 60 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Thr Pro Ala Glu Ser 65 70 75 80 Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 85 90 95 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro 100 105 110 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr 115 120 125 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 130 135 140 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro 145 150 155 160 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro 165 170 175 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 180 185 190 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 195 200 205 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr 210 215 220 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 225 230 235 240 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro 245 250 255 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser 260 265 270 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 275 280 285 Pro Gly Gly Ser Ala Pro Ala Ser Thr Arg Gly Glu Asn Ala Gly Pro 290 295 300 Ala Gly Leu Glu Ala Pro Ala Thr Ser Ser Gly Ser Glu Thr Pro Gly Thr 305 310 315 320 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 325 330 335 Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ile Gly 340 345 350 Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 355 360 365 Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 370 375 380 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 385 390 395 400 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ile Tyr Pro Tyr 405 410 415 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Ala Thr Pro 420 425 430 Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly Glu Thr Thr Gly Gly Ser 435 440 445 Ala Glu Ser Glu Pro Pro Gly Glu Gly Glu Val Gln Leu Val Glu Ser 450 455 460 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 465 470 475 480 Ala Ser Gly Phe Thr Phe Thr Asp Tyr Thr Met Asp Trp Val Arg Gln 485 490 495 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Asp Val Asn Pro Asn Ser 500 505 510 Gly Gly Ser Ile Tyr Asn Gln Arg Phe Lys Gly Arg Phe Thr Leu Ser 515 520 525 Val Asp Arg Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 530 535 540 Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn Leu Gly Pro Ser 545 550 555 560 Phe Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 565 570 575 Gly Gly Gly Ser Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val 580 585 590 Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala 595 600 605 Val Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln 610 615 620 Ala Pro Arg Gly Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr 625 630 635 640 Pro Ala Arg Phe Ser Gly Ser Ser Leu Gly Gly Ser Ala Ala Leu Thr 645 650 655 Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu 660 665 670 Trp Tyr Ser Asn Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val 675 680 685 Leu Gly Ala Thr Pro Pro Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly 690 695 700 Glu Thr Thr Gly Gly Ser Ala Glu Ser Glu Pro Pro Gly Glu Gly Glu 705 710 715 720 Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 725 730 735 Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr Ala 74 0 745 750 Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 755 760 765 Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 770 775 780 Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala 785 790 795 800 Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr 805 810 815 Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala 823 0 Tyr 8 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Gly Thr Ala Glu 835 840 845 Ala Ala Ser Ala Ser Gly Ala Ser Thr Arg Gly Glu Asn Ala Gly Pro 850 855 860 Ala Gly Leu Glu Ala Pro Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 865 870 875 880 Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gl y Pro Gly 885 890 895 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly 900 905 910 Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Ser Thr Glu Pro Ser Glu Gly 915 920 925 Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 930 935 940 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala 945 950 955 960 Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 965 970 975 Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 980 985 990 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu 995 1000 1005 Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 1010 1015 1020 Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 1025 1030 1035 Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pr o Gly Thr 1040 1045 1050 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser 1055 1060 1065 Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 1070 1075 1080 Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 1085 1090 1095 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 1100 1105 1110 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu 1115 1120 1125 Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 1130 1135 1140 Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 1145 1150 1155 Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr 1160 1165 1170 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala 1175 1180 1185 Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 1190 1195 1200 Glu Ser Gly Pro Gly Thr Ser Thr Ser Gly Pro Ser Glu Gly Ser Ala 1205 1210 1215 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr 1220 1225 1230 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu 1235 1240 1245 Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 1250 1255 1260 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 1265 1270 1275 Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr 1280 1285 1290 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser 1295 1300 1305 Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 1310 1315 1320 Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 1325 1330 1335 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 1340 1345 1350 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu 1355 1360 1365 Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 1370 1375 1380 Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 1385 1390 1395 Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser 1400 1405 1410 Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser 1415 1420 1425 Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 1430 1435 1440 Gly Ser Ala Pro Gly Thr S er Glu Ser Ala Thr Pro Glu Ser Gly 1445 1450 1455 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 1460 1465 1470 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala 1475 1480 1485 Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 1490 1495 1500 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 1505 1510 1515 Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr 1520 1525 1530 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala 1535 1540 1545 Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr Pro 1550 1555 1560 Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 1565 1570 1575 Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr 1580 1585 1590 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser 1595 1600 1605 Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro 1610 1615 1620 Glu Ser Gly Pro Gly Phe Thr Ala Asx Thr Ser Glu Ser Ala Thr 1625 1630 1635 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gl y Pro Thr 1640 1645 1650 Glu Ser Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 1655 1660 1665 Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr 1670 1675 1680 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Glu Ser Thr Pro Ser 1685 1690 1695 Glu Gly Ser Ala Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 1700 1705 1710 Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 1715 1720 1725 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Glu Pro Glu 1730 1735 1740 Ala <![CDATA[ <210> 41]]>
           <![CDATA[ <211> 2024]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 41]]> Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 1 5 10 15 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 20 25 30 Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 35 40 45 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 50 55 60 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 65 70 75 80 Glu Ser Gly Pro Gly Ser Glu Ser Ala Thr Ser Gly Ser Glu Thr Pro 85 90 95 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala 100 105 110 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 115 120 125 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Ser Ala Pro 130 135 140 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala 145 150 155 160 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu 165 170 175 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 180 185 190 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 195 200 205 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 210 215 220 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 225 230 235 240 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 245 250 255 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 260 265 270 Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 275 280 285 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 290 295 300 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 305 310 315 320 Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 325 330 335 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 340 345 350 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 355 360 365 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 370 375 380 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 385 390 395 400 Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 405 410 415 Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 420 425 430 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 435 440 445 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 450 455 460 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 465 470 475 480 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 485 490 495 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 500 505 510 Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 515 520 525 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala 530 535 540 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 545 550 555 560 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 565 570 575 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 580 585 590 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 595 600 605 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 610 615 620 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 625 630 635 640 Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 645 650 655 Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 660 665 670 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu 675 680 685 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr 690 695 700 Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Thr Glu Glu 705 710 715 720 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 725 730 735 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro 74 0 745 750 Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 755 760 765 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro 770 775 780 Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr 785 790 795 800 Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 805 810 815 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro 820 825 830 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 835 840 845 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 850 855 860 Pro Thr Gly Arg Ser Gly Glu Gly Ala Asn Ala Thr Pro Ser Gly Leu 865 870 875 880 Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Gl u Ile Val 885 890 895 Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala 900 905 910 Thr Leu Ser Cys Lys Ala Ser Gln Asp Val Ser Ile Gly Val Ala Trp 915 920 925 Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Ser Ala 930 935 940 Ser Tyr Arg Tyr Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser 945 950 955 960 Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 965 970 975 Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Ile Tyr Pro Tyr Thr Phe Gly 980 985 990 Gln Gly Thr Lys Val Glu Ile Lys Gly Ala Thr Pro Pro Glu Thr Gly 995 1000 1005 Ala Glu Thr Glu Ser Pro Gly Glu Thr Thr Gly Gly Ser Ala Glu 1010 1015 1020 Ser Glu Pro Pro Gly Glu Gly Gln Val Gln Leu Val Gln Ser Gly 1025 1030 1035 Val Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Se r Cys Lys 1040 1045 1050 Ala Ser Gly Phe Thr Phe Thr Asp Tyr Thr Met Asp Trp Val Arg 1055 1060 1065 Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Ala Asp Val Asn Pro 1070 1075 1080 Asn Ser Gly Tyr Ser I Gln Arg Phe Lys Gly Arg Val 1085 1090 1095 Thr Leu Thr Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr Met Glu Leu 1100 1105 1110 Lys Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg 1115 1120 1125 Leu Gly Pron As Ser Phe Tyr Phe Asp Tyr Trp Gly Gly Gly Thr 1130 1135 1140 Leu Val Thr Val Ser Ser Ser Gly Gly Gly Ser Glu Leu Val Val Thr 1145 1150 1155 Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 1161 17065 Thr Cys Arg Ser Ser Asn Gly Ala Val Thr Ser Ser Asn Tyr Ala 1175 1180 1185 Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile 1190 1195 1200 Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe Ser 1205 1210 1215 Gly Ser Ser Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 1220 1225 1230 Gln Pro Glu Asp Glu Ala Val Tyr Tyr Cys Ala Leu Trp Tyr Pro 1235 1240 1245 Asn Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 1250 1255 1260 Ala Thr Pro Pro Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly Glu 1265 1270 1275 Thr Thr Gly Gly Ser Ala Glu Ser Glu Pro Pro Gly Glu Gly Glu 1280 1285 1290 Val Gln Leu Gln Glu Ser Gly Gly Gly Ile Val Gln Pro Gly Gly 1295 1300 1305 Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr 1310 1315 1320 Tyr Ala Met Asn Gln Trp A la Val Arg Gly Lys Gly Leu Glu 1325 1330 1335 Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr 1340 1345 1350 Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 1355 1360 Val Thr 1365 Ser Lys Leu Gln Met Asn Asn Leu Lys Thr Glu 1370 1375 1380 Asp Thr Ala Val Tyr Tyr Cys Val Arg His Glu Asn Phe Gly Asn 1385 1390 1395 Ser Tyr Val Ser Trp Phe Ala His Trp Gly Gln Gly Thr Leu Val 1500 1 Ser Ser Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Pro 1415 1420 1425 Thr Gly Arg Ser Gly Glu Gly Ala Asn Ala Thr Pro Ser Gly Leu 1430 1435 1440 Thr Gly Pro Pro Gly Ser P ro Ala Gly Ser Pro Thr Ser Thr Glu 1445 1450 1455 Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser 1460 1465 1470 Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 1475 1480 1485 Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 1490 1495 1500 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 1505 1510 1515 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr 1520 1525 1530 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu 1535 1540 1545 Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 1550 1555 1560 Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 1565 1570 1575 Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr 1580 1585 1590 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala 1595 1600 1605 Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 1610 1615 1620 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 1625 1630 1635 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pr o Gly Thr 1640 1645 1650 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser 1655 1660 1665 Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr 1670 1675 1680 Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 1685 1690 1695 Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr 1700 1705 1710 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu 1715 1720 1725 Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 1730 1735 1740 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 1745 1750 1755 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser 1760 1765 1770 Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 1775 1780 1785 Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 1790 1795 1800 Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 1805 1810 1815 Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser 1820 1825 1830 Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 1835 1840 1845 Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr 1850 1855 1860 Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 1865 1870 1875 Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr 1880 1885 1890 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser 1895 1900 1905 Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro 1910 1915 1920 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 1925 1930 1935 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser 1940 1945 1950 Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu 1955 1960 1965 Pro Ser Glu Gly Ser Ala Pro Gly Thr Glu Ser Thr Pro Ser Glu 1970 1975 1980 Gly Ser Ala Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 1985 1990 1995 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr 2000 2005 2010 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 2015 2020 <![CDATA[ <210> 42]]>
           <![CDATA[ <211> 1456]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 42]]>
          Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Ser Gly Thr Ser Glu Ser
          1 5 10 15
          Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly
                      20 25 30
          Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly
                  35 40 45
          Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser
              50 55 60
          Ala Thr Pro Glu Ser Gly Pro Gly Ser Thr Pro Ala Glu Ser Gly Ser
          65 70 75 80
          Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly
                          85 90 95
          Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly
                      100 105 110
          Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu
                  115 120 125
          Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
              130 135 140
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly
          145 150 155 160
          Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser
                          165 170 175
          Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
                      180 185 190
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser
                  195 200 205
          Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu
              210 215 220
          Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
          225 230 235 240
          Ser Glu Pro Ala Thr Ser Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly
                          245 250 255
          Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Thr Glu Gly
                      260 265 270
          Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
                  275 280 285
          Gly Ser Ala Pro Arg Thr Gly Arg Thr Gly Glu Ser Ala Asn Glu Thr
              290 295 300
          Pro Ala Gly Leu Gly Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
          305 310 315 320
          Thr Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
                          325 330 335
          Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ile
                      340 345 350
          Gly Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
                  355 360 365
          Ile Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser
              370 375 380
          Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln
          385 390 395 400
          Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ile Tyr Pro
                          405 410 415
          Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Ala Thr Pro
                      420 425 430
          Pro Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly Glu Thr Thr Gly Gly
                  435 440 445
          Ser Ala Glu Ser Glu Pro Pro Gly Glu Gly Glu Val Gln Leu Val Glu
              450 455 460
          Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys
          465 470 475 480
          Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr Thr Met Asp Trp Val Arg
                          485 490 495
          Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Asp Val Asn Pro Asn
                      500 505 510
          Ser Gly Gly Ser Ile Tyr Asn Gln Arg Phe Lys Gly Arg Phe Thr Leu
                  515 520 525
          Ser Val Asp Arg Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu
              530 535 540
          Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn Leu Gly Pro
          545 550 555 560
          Ser Phe Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
                          565 570 575
          Ser Gly Gly Gly Ser Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr
                      580 585 590
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser Ser Asn Gly
                  595 600 605
          Ala Val Thr Ser Ser Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly
              610 615 620
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly
          625 630 635 640
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu
                          645 650 655
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Val Tyr Tyr Cys Ala
                      660 665 670
          Leu Trp Tyr Pro Asn Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr
                  675 680 685
          Val Leu Gly Ala Thr Pro Pro Glu Thr Gly Ala Glu Thr Glu Ser Pro
              690 695 700
          Gly Glu Thr Thr Gly Gly Ser Ala Glu Ser Glu Pro Pro Gly Glu Gly
          705 710 715 720
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Ile Val Gln Pro Gly Gly
                          725 730 735
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr
                      740 745 750
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
                  755 760 765
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp
              770 775 780
          Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
          785 790 795 800
          Val Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr
                          805 810 815
          Tyr Cys Val Arg His Glu Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe
                      820 825 830
          Ala His Trp Gly Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Thr Ala
                  835 840 845
          Glu Ala Ala Ser Ala Ser Gly Arg Thr Gly Arg Thr Gly Glu Ser Ala
              850 855 860
          Asn Glu Thr Pro Ala Gly Leu Gly Gly Pro Pro Gly Ser Pro Ala Gly
          865 870 875 880
          Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu
                          885 890 895
          Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      900 905 910
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu
                  915 920 925
          Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly
              930 935 940
          Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
          945 950 955 960
          Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu
                          965 970 975
          Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly
                      980 985 990
          Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly
                  995 1000 1005
          Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu
              1010 1015 1020
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
              1025 1030 1035
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser
              1040 1045 1050
          Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
              1055 1060 1065
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr
              1070 1075 1080
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
              1085 1090 1095
          Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr
              1100 1105 1110
          Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly
              1115 1120 1125
          Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu
              1130 1135 1140
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
              1145 1150 1155
          Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser
              1160 1165 1170
          Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
              1175 1180 1185
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro
              1190 1195 1200
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr
              1205 1210 1215
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser
              1220 1225 1230
          Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly
              1235 1240 1245
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro
              1250 1255 1260
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr
              1265 1270 1275
          Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr
              1280 1285 1290
          Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly
              1295 1300 1305
          Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu
              1310 1315 1320
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Ser Glu Ser Ala Thr
              1325 1330 1335
          Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser
              1340 1345 1350
          Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
              1355 1360 1365
          Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala
              1370 1375 1380
          Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser
              1385 1390 1395
          Glu Gly Ser Ala Pro Gly Thr Glu Ser Thr Pro Ser Glu Gly Ser
              1400 1405 1410
          Ala Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
              1415 1420 1425
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr
              1430 1435 1440
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Glu Pro Glu Ala
              1445 1450 1455
           <![CDATA[ <210> 43]]>
           <![CDATA[ <211> 1743]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 43]]> Ala Ser Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Ser Gly Thr Ser 1 5 10 15 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 20 25 30 Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 35 40 45 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 50 55 60 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Thr Pro Ala Glu Ser 65 70 75 80 Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 85 90 95 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro 100 105 110 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr 115 120 125 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 130 135 140 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro 145 150 155 160 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro 165 170 175 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 180 185 190 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 195 200 205 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr 210 215 220 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 225 230 235 240 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro 245 250 255 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser 260 265 270 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Ser Ala 275 280 285 Pro Gly Gly Ser Ala Pro Thr Thr Ala Arg Ala Gly Ser Ala Glu Asn 290 295 300 Leu Ser Pro Ser Gly Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr 305 310 315 320 Pro Gly Thr Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 325 330 335 Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val 340 345 350 Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 355 360 365 Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg 370 375 380 Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 385 390 395 400 Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr 405 410 415 Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Ala 420 425 430 Thr Pro Pro Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly Glu Thr Thr 435 440 445 Gly Gly Ser Ala Glu Ser Glu Pro Pro Gly Glu Gly Glu Val Gln Leu 450 455 460 Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 465 470 475 480 Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp 485 490 495 Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr 500 505 510 Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe 515 520 525 Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn 530 535 540 Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly 545 550 555 560 Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 565 570 575 Thr Val Ser Ser Gly Gly Gly Ser Glu Leu Val Val Thr Gln Glu Pro 580 585 590 Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser 595 600 605 Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Gln 610 615 620 Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Asn Lys Arg 625 630 635 640 Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys 645 650 655 Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr 660 665 670 Tyr Cys Ala Leu Trp Tyr Ser Asn Leu Trp Val Phe Gly Gly Gly Thr 675 680 685 Lys Leu Thr Val Leu Gly Ala Thr Pro Pro Glu Thr Gly Ala Glu Thr 690 695 700 Glu Ser Pro Gly Glu Thr Thr Thr Gly Gly Ser Ala Glu Ser Glu Pro Pro 705 710 715 720 Gly Glu Gly Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln 725 730 735 Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 74 0 745 750 Asn Thr Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 755 760 765 Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr 770 775 780 Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser 785 790 795 800 Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr 805 810 815 Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val 820 825 83 Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 835 840 845 Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Ala Arg Ala Gly 850 855 860 Ser Ala Glu Asn Leu Ser Pro Ser Gly Leu Thr Gly Pro Pro Gly Ser 865 870 875 880 Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Gl u Ser Ala 885 890 895 Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 900 905 910 Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr 915 920 925 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro 930 935 940 Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 945 950 955 960 Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser 965 970 975 Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser 980 985 990 Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 995 1000 1005 Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 1010 1015 1020 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala 1025 1030 1035 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Gl u Pro Ser 1040 1045 1050 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 1055 1060 1065 Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 1070 1075 1080 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 1085 1090 1095 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 1100 1105 1110 Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 1115 1120 1125 Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 1130 1135 1140 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu 1145 1150 1155 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro 1160 1165 1170 Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 1175 1180 1185 Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 1190 1195 1200 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 1205 1210 1215 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser 1220 1225 1230 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 1235 1240 1245 Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 1250 1255 1260 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 1265 1270 1275 Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro 1280 1285 1290 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 1295 1300 1305 Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 1310 1315 1320 Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu 1325 1330 1335 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 1340 1345 1350 Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 1355 1360 1365 Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 1370 1375 1380 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala 1385 1390 1395 Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro 1400 1405 1410 Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 1415 1420 1425 Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 1430 1435 1440 Thr Ser Thr Glu Pro Ser G lu Gly Ser Ala Pro Gly Thr Ser Glu 1445 1450 1455 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 1460 1465 1470 Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 1475 1480 1485 Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 1490 1495 1500 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 1505 1510 1515 Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro 1520 1525 1530 Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 1535 1540 1545 Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 1550 1555 1560 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala 1565 1570 1575 Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro 1580 1585 1590 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 1595 1600 1605 Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 1610 1615 1620 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu 1625 1630 1635 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Al a Thr Ser 1640 1645 1650 Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 1655 1660 1665 Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 1670 1675 1680 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Glu Ser 1685 1690 1695 Thr Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro Ala Thr Ser 1700 1705 1710 Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 1715 1720 1725 Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 1730 1735 1740 <![CDATA[ <210> 44]]>
           <![CDATA[ <211> 1446]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 44]]>
          Ala Ser Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Ser Gly Thr Ser
          1 5 10 15
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
                      20 25 30
          Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  35 40 45
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
              50 55 60
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Thr Pro Ala Glu Ser
          65 70 75 80
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                          85 90 95
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro
                      100 105 110
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
                  115 120 125
          Pro Glu Ser Gly Pro Gly Glu Glu Pro Ala Thr Ser Gly Ser Thr Pro
              130 135 140
          Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro
          145 150 155 160
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro
                          165 170 175
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
                      180 185 190
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                  195 200 205
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr
              210 215 220
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
          225 230 235 240
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro
                          245 250 255
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser
                      260 265 270
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                  275 280 285
          Pro Gly Gly Ser Ala Pro Leu Gly Gly Arg Ala Asp Asn His Glu Pro
              290 295 300
          Pro Glu Leu Gly Ala Gly Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
          305 310 315 320
          Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
                          325 330 335
          Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ile Gly
                      340 345 350
          Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
                  355 360 365
          Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly
              370 375 380
          Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
          385 390 395 400
          Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ile Tyr Pro Tyr
                          405 410 415
          Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Ala Thr Pro Pro
                      420 425 430
          Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly Glu Thr Thr Gly Gly Ser
                  435 440 445
          Ala Glu Ser Glu Pro Pro Gly Glu Gly Glu Val Gln Leu Val Glu Ser
              450 455 460
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala
          465 470 475 480
          Ala Ser Gly Phe Thr Phe Thr Asp Tyr Thr Met Asp Trp Val Arg Gln
                          485 490 495
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Asp Val Asn Pro Asn Ser
                      500 505 510
          Gly Gly Ser Ile Tyr Asn Gln Arg Phe Lys Gly Arg Phe Thr Leu Ser
                  515 520 525
          Val Asp Arg Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg
              530 535 540
          Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn Leu Gly Pro Ser
          545 550 555 560
          Phe Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                          565 570 575
          Gly Gly Gly Ser Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val
                      580 585 590
          Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser Ser Asn Gly Ala
                  595 600 605
          Val Thr Ser Ser Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln
              610 615 620
          Ala Pro Arg Gly Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr
          625 630 635 640
          Pro Ala Arg Phe Ser Gly Ser Ser Leu Gly Gly Lys Ala Ala Leu Thr
                          645 650 655
          Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Val Tyr Tyr Cys Ala Leu
                      660 665 670
          Trp Tyr Pro Asn Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val
                  675 680 685
          Leu Gly Ala Thr Pro Pro Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly
              690 695 700
          Glu Thr Thr Gly Gly Ser Ala Glu Ser Glu Pro Pro Gly Glu Gly Glu
          705 710 715 720
          Val Gln Leu Gln Glu Ser Gly Gly Gly Ile Val Gln Pro Gly Gly Ser
                          725 730 735
          Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr Ala
                      740 745 750
          Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala
                  755 760 765
          Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser
              770 775 780
          Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Val
          785 790 795 800
          Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr
                          805 810 815
          Cys Val Arg His Glu Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala
                      820 825 830
          His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Thr Ala Glu
                  835 840 845
          Ala Ala Ser Ala Ser Gly Leu Gly Gly Arg Ala Asp Asn His Glu Pro
              850 855 860
          Pro Glu Leu Gly Ala Gly Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu
          865 870 875 880
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr
                          885 890 895
          Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                      900 905 910
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu
                  915 920 925
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu
              930 935 940
          Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
          945 950 955 960
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Ser Thr
                          965 970 975
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu
                      980 985 990
          Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
                  995 1000 1005
          Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
              1010 1015 1020
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala
              1025 1030 1035
          Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser
              1040 1045 1050
          Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
              1055 1060 1065
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
              1070 1075 1080
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro
              1085 1090 1095
          Ser Glu Gly Ser Ala Pro Gly Thr Ser Ser Glu Ser Ala Thr Pro Glu
              1100 1105 1110
          Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
              1115 1120 1125
          Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro
              1130 1135 1140
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala
              1145 1150 1155
          Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly
              1160 1165 1170
          Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
              1175 1180 1185
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
              1190 1195 1200
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr
              1205 1210 1215
          Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr Pro Glu
              1220 1225 1230
          Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
              1235 1240 1245
          Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
              1250 1255 1260
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr
              1265 1270 1275
          Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr Pro Glu
              1280 1285 1290
          Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
              1295 1300 1305
          Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
              1310 1315 1320
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala
              1325 1330 1335
          Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu
              1340 1345 1350
          Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
              1355 1360 1365
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu
              1370 1375 1380
          Ser Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser
              1385 1390 1395
          Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly
              1400 1405 1410
          Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
              1415 1420 1425
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
              1430 1435 1440
          Glu Ser Ala
              1445
           <![CDATA[ <210> 45]]>
           <![CDATA[ <211> 1451]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 45]]>
          Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Ser Gly Thr Ser Glu Ser
          1 5 10 15
          Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly
                      20 25 30
          Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly
                  35 40 45
          Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser
              50 55 60
          Ala Thr Pro Glu Ser Gly Pro Gly Ser Thr Pro Ala Glu Ser Gly Ser
          65 70 75 80
          Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly
                          85 90 95
          Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly
                      100 105 110
          Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu
                  115 120 125
          Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
              130 135 140
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly
          145 150 155 160
          Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser
                          165 170 175
          Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
                      180 185 190
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser
                  195 200 205
          Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu
              210 215 220
          Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
          225 230 235 240
          Ser Glu Pro Ala Thr Ser Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly
                          245 250 255
          Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Thr Glu Gly
                      260 265 270
          Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
                  275 280 285
          Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Glu Ala Glu Gly Ala Thr
              290 295 300
          Ser Ala Gly Ala Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
          305 310 315 320
          Thr Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
                          325 330 335
          Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr
                      340 345 350
          Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
                  355 360 365
          Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser
              370 375 380
          Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln
          385 390 395 400
          Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro
                          405 410 415
          Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Ala Thr Pro
                      420 425 430
          Pro Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly Glu Thr Thr Gly Gly
                  435 440 445
          Ser Ala Glu Ser Glu Pro Pro Gly Glu Gly Glu Val Gln Leu Val Glu
              450 455 460
          Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys
          465 470 475 480
          Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg
                          485 490 495
          Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr
                      500 505 510
          Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile
                  515 520 525
          Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu
              530 535 540
          Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp
          545 550 555 560
          Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val
                          565 570 575
          Ser Ser Gly Gly Gly Ser Glu Leu Val Val Thr Gln Glu Pro Ser Leu
                      580 585 590
          Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser Ser Thr
                  595 600 605
          Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro
              610 615 620
          Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro
          625 630 635 640
          Gly Thr Pro Ala Arg Phe Ser Gly Ser Ser Leu Gly Gly Ser Ala Ala
                          645 650 655
          Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys
                      660 665 670
          Ala Leu Trp Tyr Ser Asn Leu Trp Val Phe Gly Gly Gly Thr Lys Leu
                  675 680 685
          Thr Val Leu Gly Ala Thr Pro Pro Glu Thr Gly Ala Glu Thr Glu Ser
              690 695 700
          Pro Gly Glu Thr Thr Gly Gly Ser Ala Glu Ser Glu Pro Pro Gly Glu
          705 710 715 720
          Gly Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
                          725 730 735
          Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr
                      740 745 750
          Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
                  755 760 765
          Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala
              770 775 780
          Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn
          785 790 795 800
          Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val
                          805 810 815
          Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp
                      820 825 830
          Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Thr
                  835 840 845
          Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly Glu Ala
              850 855 860
          Glu Gly Ala Thr Ser Ala Gly Ala Thr Gly Pro Glu Gly Ser Ala Pro
          865 870 875 880
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu
                          885 890 895
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu
                      900 905 910
          Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                  915 920 925
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Thr
              930 935 940
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu
          945 950 955 960
          Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                          965 970 975
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala
                      980 985 990
          Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro
                  995 1000 1005
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
              1010 1015 1020
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr
              1025 1030 1035
          Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu
              1040 1045 1050
          Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu
              1055 1060 1065
          Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
              1070 1075 1080
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr
              1085 1090 1095
          Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly
              1100 1105 1110
          Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu
              1115 1120 1125
          Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
              1130 1135 1140
          Pro Gly Ser Glu Pro Ala Thr Ser Ser Gly Ser Glu Thr Pro Gly Thr
              1145 1150 1155
          Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala
              1160 1165 1170
          Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro
              1175 1180 1185
          Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
              1190 1195 1200
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser
              1205 1210 1215
          Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly
              1220 1225 1230
          Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr
              1235 1240 1245
          Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
              1250 1255 1260
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr
              1265 1270 1275
          Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala
              1280 1285 1290
          Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro
              1295 1300 1305
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
              1310 1315 1320
          Pro Gly Thr Ser Glu Ser Ala Ser Pro Glu Ser Gly Pro Gly Thr
              1325 1330 1335
          Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly
              1340 1345 1350
          Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro
              1355 1360 1365
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
              1370 1375 1380
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser
              1385 1390 1395
          Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly
              1400 1405 1410
          Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu
              1415 1420 1425
          Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
              1430 1435 1440
          Pro Gly Thr Ser Glu Ser Ala Thr
              1445 1450
           <![CDATA[ <210> 46]]>
           <![CDATA[ <211> 2609]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 46]]> Ser Ala Gly Ser Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 1 5 10 15 Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 20 25 30 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro 35 40 45 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 50 55 60 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 65 70 75 80 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Thr Pro Ala Glu Ser 85 90 95 Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 100 105 110 Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 115 120 125 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 130 135 140 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 145 150 155 160 Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 165 170 175 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser 180 185 190 Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 195 200 205 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 210 215 220 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 225 230 235 240 Gly Ser Thr Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 245 250 255 Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr 260 265 270 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala 275 280 285 Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 290 295 300 Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser 305 310 315 320 Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala 325 330 335 Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 340 345 350 Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr 355 360 365 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro 370 375 380 Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 385 390 395 400 Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser 405 410 415 Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro 420 425 430 Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 435 440 445 Gly Pro Gly Ser Glu Pro Ala Thr Ser Ser Gly Ser Glu Thr Pro Gly Thr 450 455 460 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr 465 470 475 480 Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 485 490 495 Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr 500 505 510 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser 515 520 525 Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 530 535 540 Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr 545 550 555 560 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro 565 570 575 Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 580 585 590 Gly Pro Gly Ser Glu Pro Ala Thr Ser Ser Gly Ser Glu Thr Pro Gly Thr 595 600 605 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr 610 615 620 Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 625 630 635 640 Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser 645 650 655 Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala 660 665 670 Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 675 680 685 Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser 690 695 700 Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser 705 710 715 720 Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 725 730 735 Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr 74 0 745 750 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala 755 760 765 Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 770 775 780 Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser 785 790 795 800 Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro 805 810 815 Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 820 825 830 Ala Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 835 840 845 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro 850 855 860 Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 865 870 875 880 Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pr o Gly Thr 885 890 895 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser 900 905 910 Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 915 920 925 Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr 930 935 940 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr 945 950 955 960 Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 965 970 975 Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr 980 985 990 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro 995 1000 1005 Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 1010 1015 1020 Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 1025 1030 1035 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gl y Thr Ser 1040 1045 1050 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala 1055 1060 1065 Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 1070 1075 1080 Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 1085 1090 1095 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 1100 1105 1110 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro 1115 1120 1125 Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 1130 1135 1140 Ser Gly Pro Gly Thr Glu Ser Ala Ser Thr Thr Gly Arg Ala Gly 1145 1150 1155 Glu Ala Ala Asn Ala Thr Ser Ala Gly Ala Thr Gly Pro Ala Thr 1160 1165 1170 Ser Gly Ser Glu Thr Pro Gly Thr Asp Ile Gln Met Thr Gln Ser 1175 1180 1185 Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 1190 1195 1200 Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln 1205 1210 1215 Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser 1220 1225 1230 Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser 1235 1240 1245 Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 1250 1255 1260 Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr 1265 1270 1275 Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Ala Thr Pro Pro 1280 1285 1290 Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly Glu Thr Thr Gly Gly 1295 1300 1305 Ser Ala Glu Ser Glu Pro Pro Gly Glu Gly Glu Val Gln Leu Val 1310 1315 1320 Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 1325 1330 1335 Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His 1340 1345 1350 Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg 1355 1360 1365 Ile Asn Tyr G Pro Thr Tyr Thr Arg Tyr Ala Asp Ser Val Lys 1370 1375 1380 Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 1385 1390 1395 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 1401 410 C5 Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp 1415 1420 1425 Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Gly Gly Ser Glu 1430 1435 1440 Leu Val Val Thr Gln Glu P ro Ser Leu Thr Val Ser Pro Gly Gly 1445 1450 1455 Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr 1460 1465 1470 Ser Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro 1475 148 Arg0 Gly 1485 Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro 1490 1495 1500 Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr 1505 1510 1515 Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala 1520 1525 1530 Leu Trp Tyr Ser Asn Leu Trp Val Phe Gly Gly Gly Thr Lys Leu 1535 1540 1545 Thr Val Leu Gly Ala Thr Pro Pro Glu Thr Gly Ala Glu Thr Glu 1550 1555 1560 Ser Pro Gly Glu Thr Thr Thr Gly Gly Ser Ala Glu Ser Glu Pro Pro 1565 1570 1575 Gly Glu Gly Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val 1580 1585 1590 Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe 1595 1600 1605 Thr Phe Asn Thr Tyr Asn Ala Met Trp Val Arg Gln Ala Pro Gly 1610 1615 1620 Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn 1625 1630 1635 Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Ph e Thr Ile 1640 1645 1650 Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 1655 1660 1665 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly 1670 1675 1680 Val Ser Pheer Tyr Asn Trp Phe Ala Tyr Trp Gly Gln 1685 1690 1695 Gly Thr Leu Val Thr Val Ser Ser Gly Thr Ala Glu Ala Ala Ser 1700 1705 1710 Ala Ser Gly Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Ala Thr 1715 1720 1725 Ala Gly Ala Ser Thr Gly Pro Pro Gly Ser Pro Ala Gly Ser Pro 1730 1735 1740 Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 1745 1750 1755 Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 1760 1765 1770 Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr 1775 1780 1785 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser 1790 1795 1800 Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 1805 1810 1815 Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 1820 1825 1830 Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala 1835 1840 1845 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr 1850 1855 1860 Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 1865 1870 1875 Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 1880 1885 1890 Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr 1895 1900 1905 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser 1910 1915 1920 Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 1925 1930 1935 Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 1940 1945 1950 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 1955 1960 1965 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser 1970 1975 1980 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 1985 1990 1995 Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 2000 2005 2010 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala 2015 2020 2025 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr 2030 2035 2040 Pro Glu Ser Gly Pro Gly S er Glu Pro Ala Thr Ser Gly Ser Glu 2045 2050 2055 Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 2060 2065 2070 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 2075 2080 2085 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser 2090 2095 2100 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 2105 2110 2115 Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 2120 2125 2130 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala 2135 2140 2145 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser 2150 2155 2160 Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 2165 2170 2175 Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 2180 2185 2190 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 2195 2200 2205 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 2210 2215 2220 Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 2225 2230 2235 Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gl y Pro Gly 2240 2245 2250 Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala 2255 2260 2265 Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro 2270 2275 2280 Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 2285 2290 2295 Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 2300 2305 2310 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 2315 2320 2325 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 2330 2335 2340 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 2345 2350 2355 Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 2360 2365 2370 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala 2375 2380 2385 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr 2390 2395 2400 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 2405 2410 2415 Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 2420 2425 2430 Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala 2435 2440 2445 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser 2450 2455 2460 Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 2465 2470 2475 Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 2480 2485 2490 Phe Thr Ala Asx Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 2495 2500 2505 Gly Ser Glu Pro Ala Thr Ser Gly Pro Thr Glu Ser Gly Ser Glu 2510 2515 2520 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser 2525 2530 2535 Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly 2540 2545 2550 Ser Ala Pro Gly Thr Glu Ser Thr Pro Ser Glu Gly Ser Ala Pro 2555 2560 2565 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 2570 2575 2580 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro 2585 2590 2595 Ser Glu Gly Ser Ala Pro Gly Glu Pro Glu Ala 2600 2605 <![CDATA[ <210> 47]]>
           <![CDATA[ <211> 1458]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 47]]>
          Ala Ser Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Ser Gly Thr Ser
          1 5 10 15
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Glu Thr Glu Pro Ser
                      20 25 30
          Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  35 40 45
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
              50 55 60
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Thr Pro Ala Glu Ser
          65 70 75 80
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                          85 90 95
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro
                      100 105 110
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
                  115 120 125
          Pro Glu Ser Gly Pro Gly Glu Ser Pro Ala Thr Ser Gly Ser Thr Pro
              130 135 140
          Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro
          145 150 155 160
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro
                          165 170 175
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
                      180 185 190
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                  195 200 205
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr
              210 215 220
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
          225 230 235 240
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro
                          245 250 255
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser
                      260 265 270
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                  275 280 285
          Pro Gly Gly Ser Ala Pro Thr Thr Gly Arg Ala Thr Glu Ala Ala Asn
              290 295 300
          Ala Thr Pro Ala Gly Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr
          305 310 315 320
          Pro Gly Thr Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu
                          325 330 335
          Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Asp Val
                      340 345 350
          Ser Ile Gly Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg
                  355 360 365
          Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ala Arg
              370 375 380
          Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser
          385 390 395 400
          Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Ile
                          405 410 415
          Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Ala
                      420 425 430
          Thr Pro Pro Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly Glu Thr Thr
                  435 440 445
          Gly Gly Ser Ala Glu Ser Glu Pro Pro Gly Glu Gly Gln Val Gln Leu
              450 455 460
          Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val
          465 470 475 480
          Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Asp Tyr Thr Met Asp Trp
                          485 490 495
          Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Ala Asp Val Asn
                      500 505 510
          Pro Asn Ser Gly Gly Ser Ile Tyr Asn Gln Arg Phe Lys Gly Arg Val
                  515 520 525
          Thr Leu Thr Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr Met Glu Leu Lys
              530 535 540
          Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn Leu
          545 550 555 560
          Gly Pro Ser Phe Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr
                          565 570 575
          Val Ser Ser Gly Gly Gly Ser Glu Leu Val Val Thr Gln Glu Pro Ser
                      580 585 590
          Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser Ser
                  595 600 605
          Asn Gly Ala Val Thr Ser Ser Asn Tyr Ala Asn Trp Val Gln Gln Lys
              610 615 620
          Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Asn Lys Arg Ala
          625 630 635 640
          Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala
                          645 650 655
          Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Val Tyr Tyr
                      660 665 670
          Cys Ala Leu Trp Tyr Pro Asn Leu Trp Val Phe Gly Gly Gly Thr Lys
                  675 680 685
          Leu Thr Val Leu Gly Ala Thr Pro Pro Glu Thr Gly Ala Glu Thr Glu
              690 695 700
          Ser Pro Gly Glu Thr Thr Gly Gly Ser Ala Glu Ser Glu Pro Pro Gly
          705 710 715 720
          Glu Gly Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Ile Val Gln Pro
                          725 730 735
          Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn
                      740 745 750
          Thr Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu
                  755 760 765
          Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr
              770 775 780
          Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys
          785 790 795 800
          Asn Thr Val Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala
                          805 810 815
          Val Tyr Tyr Cys Val Arg His Glu Asn Phe Gly Asn Ser Tyr Val Ser
                      820 825 830
          Trp Phe Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly
                  835 840 845
          Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Thr Glu
              850 855 860
          Ala Ala Asn Ala Thr Pro Ala Gly Leu Thr Gly Pro Pro Gly Ser Pro
          865 870 875 880
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
                          885 890 895
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
                      900 905 910
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                  915 920 925
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser
              930 935 940
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
          945 950 955 960
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                          965 970 975
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser
                      980 985 990
          Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
                  995 1000 1005
          Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr
              1010 1015 1020
          Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala
              1025 1030 1035
          Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro
              1040 1045 1050
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
              1055 1060 1065
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr
              1070 1075 1080
          Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser
              1085 1090 1095
          Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr
              1100 1105 1110
          Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
              1115 1120 1125
          Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr
              1130 1135 1140
          Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu
              1145 1150 1155
          Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro
              1160 1165 1170
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
              1175 1180 1185
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser
              1190 1195 1200
          Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser
              1205 1210 1215
          Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu
              1220 1225 1230
          Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
              1235 1240 1245
          Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser
              1250 1255 1260
          Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser
              1265 1270 1275
          Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr
              1280 1285 1290
          Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
              1295 1300 1305
          Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr
              1310 1315 1320
          Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser
              1325 1330 1335
          Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro
              1340 1345 1350
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
              1355 1360 1365
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser
              1370 1375 1380
          Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu
              1385 1390 1395
          Pro Ser Glu Gly Ser Ala Pro Gly Thr Glu Ser Thr Pro Ser Glu
              1400 1405 1410
          Gly Ser Ala Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
              1415 1420 1425
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr
              1430 1435 1440
          Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Glu Pro Glu Ala
              1445 1450 1455
           <![CDATA[ <210> 48]]>
           <![CDATA[ <211> 6]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 48]]>
          His His His His His His His His
          1 5
           <![CDATA[ <210> 49]]>
           <![CDATA[ <211> 8]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 49]]>
          His His His His His His His His His His His
          1 5
           <![CDATA[ <210> 50]]>
           <![CDATA[ <211> 11]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 50]]>
          Arg Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn
          1 5 10
           <![CDATA[ <210> 51]]>
           <![CDATA[ <211> 22]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 51]]>
          Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly
          1 5 10 15
          Thr Val Thr Leu Thr Cys
                      20
           <![CDATA[ <210> 52]]>
           <![CDATA[ <211> 15]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 52]]>
          Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly
          1 5 10 15
           <![CDATA[ <210> 53]]>
           <![CDATA[ <211> 32]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 53]]>
          Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala
          1 5 10 15
          Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Val Tyr Tyr Cys
                      20 25 30
           <![CDATA[ <210> 54]]>
           <![CDATA[ <211> 32]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 54]]>
          Gly Thr Pro Ala Arg Phe Ser Gly Ser Ser Ser Leu Gly Gly Lys Ala Ala
          1 5 10 15
          Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Val Tyr Tyr Cys
                      20 25 30
           <![CDATA[ <210> 55]]>
           <![CDATA[ <211> 32]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 55]]>
          Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Ser Ala Ala
          1 5 10 15
          Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Val Tyr Tyr Cys
                      20 25 30
           <![CDATA[ <210> 56]]>
           <![CDATA[ <211> 32]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 56]]>
          Gly Thr Pro Ala Arg Phe Ser Gly Ser Ser Leu Gly Gly Ser Ala Ala
          1 5 10 15
          Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Val Tyr Tyr Cys
                      20 25 30
           <![CDATA[ <210> 57]]>
           <![CDATA[ <211> 32]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 57]]>
          Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala
          1 5 10 15
          Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys
                      20 25 30
           <![CDATA[ <210> 58]]>
           <![CDATA[ <211> 32]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 58]]>
          Gly Thr Pro Ala Arg Phe Ser Gly Ser Ser Leu Gly Gly Ser Ala Ala
          1 5 10 15
          Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys
                      20 25 30
           <![CDATA[ <210> 59]]>
           <![CDATA[ <211> 9]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 59]]>
          Gly Gly Gly Thr Lys Leu Thr Val Leu
          1 5
           <![CDATA[ <210> 60]]>
           <![CDATA[ <211> 25]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 60]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Ile Val Gln Pro Gly Gly
          1 5 10 15
          Ser Leu Lys Leu Ser Cys Ala Ala Ser
                      20 25
           <![CDATA[ <210> 61]]>
           <![CDATA[ <211> 25]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 61]]>
          Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Ile Val Gln Pro Gly Gly
          1 5 10 15
          Ser Leu Lys Leu Ser Cys Ala Ala Ser
                      20 25
           <![CDATA[ <210> 62]]>
           <![CDATA[ <211> 25]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 62]]>
          Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
          1 5 10 15
          Ser Leu Lys Leu Ser Cys Ala Ala Ser
                      20 25
           <![CDATA[ <210> 63]]>
           <![CDATA[ <211> 25]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 63]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
          1 5 10 15
          Ser Leu Lys Leu Ser Cys Ala Ala Ser
                      20 25
           <![CDATA[ <210> 64]]>
           <![CDATA[ <211> 14]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 64]]>
          Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala
          1 5 10
           <![CDATA[ <210> 65]]>
           <![CDATA[ <211> 32]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 65]]>
          Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Val Tyr Leu Gln
          1 5 10 15
          Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg
                      20 25 30
           <![CDATA[ <210> 66]]>
           <![CDATA[ <211> 32]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 66]]>
          Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln
          1 5 10 15
          Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg
                      20 25 30
           <![CDATA[ <210> 67]]>
           <![CDATA[ <211> 11]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 67]]>
          Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
          1 5 10
           <![CDATA[ <210> 68]]>
           <![CDATA[ <211> 10]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 68]]>
          Ser Pro Ala Thr Ser Gly Ser Thr Pro Glu
          1 5 10
           <![CDATA[ <210> 69]]>
           <![CDATA[ <211> 8]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 69]]>
          Gly Ser Ala Pro Ala Thr Ser Glu
          1 5
           <![CDATA[ <210> 70]]>
           <![CDATA[ <211> 9]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 70]]>
          Gly Ser Ala Pro Gly Thr Ala Thr Glu
          1 5
           <![CDATA[ <210> 71]]>
           <![CDATA[ <211> 7]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 71]]>
          Gly Ser Ala Pro Gly Thr Glu
          1 5
           <![CDATA[ <210> 72]]>
           <![CDATA[ <211> 8]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 72]]>
          Pro Ala Thr Ser Gly Pro Thr Glu
          1 5
           <![CDATA[ <210> 73]]>
           <![CDATA[ <211> 5]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 73]]>
          Ser Ala Ser Pro Glu
          1 5
           <![CDATA[ <210> 74]]>
           <![CDATA[ <211> 8]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 74]]>
          Pro Ala Thr Ser Gly Ser Thr Glu
          1 5
           <![CDATA[ <210> 75]]>
           <![CDATA[ <211> 9]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 75]]>
          Gly Ser Ala Pro Gly Thr Ser Ala Glu
          1 5
           <![CDATA[ <210> 76]]>
           <![CDATA[ <211> 7]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 76]]>
          Ser Ala Thr Ser Ser Gly Ser Glu
          1 5
           <![CDATA[ <210> 77]]>
           <![CDATA[ <211> 9]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 77]]>
          Ser Gly Pro Gly Ser Thr Pro Ala Glu
          1 5
           <![CDATA[ <210> 78]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 78]]>
          Tyr Thr Ser Arg Leu Glu Ser Gln Gln Gly Asn Thr Leu Pro Trp Thr
          1 5 10 15
           <![CDATA[ <210> 79]]>
           <![CDATA[ <211> 10]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 79]]>
          Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn
          1 5 10
           <![CDATA[ <210> 80]]>
           <![CDATA[ <211> 10]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 80]]>
          Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr
          1 5 10
           <![CDATA[ <210> 81]]>
           <![CDATA[ <211> 13]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 81]]>
          Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val
          1 5 10
           <![CDATA[ <210> 82]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 82]]>
          Gly Ser Gly Glu Gly Ser Glu Gly Glu Gly Gly Gly Gly Glu Gly Ser Glu
          1 5 10 15
          Gly Glu Gly Ser Gly Glu Gly Gly Glu Gly Glu Gly Ser Gly
                      20 25 30
           <![CDATA[ <210> 83]]>
           <![CDATA[ <211> 32]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 83]]>
          Thr Gly Ser Gly Glu Gly Ser Glu Gly Glu Gly Gly Gly Glu Gly Ser
          1 5 10 15
          Glu Gly Glu Gly Ser Gly Glu Gly Gly Glu Gly Glu Gly Ser Gly Thr
                      20 25 30
           <![CDATA[ <210> 84]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 84]]>
          Gly Ala Thr Pro Pro Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly Glu
          1 5 10 15
          Thr Thr Gly Gly Ser Ala Glu Ser Glu Pro Pro Gly Glu Gly
                      20 25 30
           <![CDATA[ <210> 85]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 85]]>
          Gly Ser Ala Ala Pro Thr Ala Gly Thr Thr Pro Ser Ala Ser Pro Ala
          1 5 10 15
          Pro Pro Thr Gly Gly Ser Ser Ala Ala Gly Ser Pro Ser Thr
                      20 25 30
           <![CDATA[ <210> 86]]>
           <![CDATA[ <211> 6]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 86]]>
          Ser Gly Gly Gly Gly Ser
          1 5
           <![CDATA[ <210> 87]]>
           <![CDATA[ <211> 5]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 87]]>
          Gly Gly Gly Gly Ser
          1 5
           <![CDATA[ <210> 88]]>
           <![CDATA[ <211> 6]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 88]]>
          Gly Gly Ser Gly Gly Ser
          1 5
           <![CDATA[ <210> 89]]>
           <![CDATA[ <211> 5]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 89]]>
          Ser Thr Glu Pro Ser
          1 5
           <![CDATA[ <210> 90]]>
           <![CDATA[ <211> 10]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 90]]>
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr
          1 5 10
           <![CDATA[ <210> 91]]>
           <![CDATA[ <211> 10]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 91]]>
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
          1 5 10
           <![CDATA[ <210> 92]]>
           <![CDATA[ <211> 10]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 92]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly
          1 5 10
           <![CDATA[ <210> 93]]>
           <![CDATA[ <211> 13]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 93]]>
          Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
          1 5 10
           <![CDATA[ <210> 94]]>
           <![CDATA[ <211> 6]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 94]]>
          Ser Gly Pro Gly Thr Ser
          1 5
           <![CDATA[ <210> 95]]>
           <![CDATA[ <211> 7]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 95]]>
          Gly Thr Ser Thr Glu Pro Ser
          1 5
           <![CDATA[ <210> 96]]>
           <![CDATA[ <211> 10]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 96]]>
          Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu
          1 5 10
           <![CDATA[ <210> 97]]>
           <![CDATA[ <211> 14]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 97]]>
          Gly Ser Ala Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu
          1 5 10
           <![CDATA[ <210> 98]]>
           <![CDATA[ <211> 864]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 98]]>
          Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu
          1 5 10 15
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu
                      20 25 30
          Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
                  35 40 45
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Ser Thr
              50 55 60
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro
          65 70 75 80
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro
                          85 90 95
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala
                      100 105 110
          Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro
                  115 120 125
          Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
              130 135 140
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala
          145 150 155 160
          Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu
                          165 170 175
          Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
                      180 185 190
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Ser Thr
                  195 200 205
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro
              210 215 220
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro
          225 230 235 240
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Ser Thr
                          245 250 255
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro
                      260 265 270
          Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                  275 280 285
          Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu
              290 295 300
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly
          305 310 315 320
          Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                          325 330 335
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Ser Thr
                      340 345 350
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu
                  355 360 365
          Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
              370 375 380
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Ser Thr
          385 390 395 400
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr
                          405 410 415
          Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala Pro
                      420 425 430
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro
                  435 440 445
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro
              450 455 460
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro
          465 470 475 480
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Ser Thr
                          485 490 495
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro
                      500 505 510
          Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
                  515 520 525
          Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala
              530 535 540
          Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro
          545 550 555 560
          Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
                          565 570 575
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro
                      580 585 590
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro
                  595 600 605
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro
              610 615 620
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Ser Thr
          625 630 635 640
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr
                          645 650 655
          Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                      660 665 670
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu
                  675 680 685
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr
              690 695 700
          Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
          705 710 715 720
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu
                          725 730 735
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Ser Glu Ser Ala Thr Pro
                      740 745 750
          Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                  755 760 765
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro
              770 775 780
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr
          785 790 795 800
          Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala Pro
                          805 810 815
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro
                      820 825 830
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro
                  835 840 845
          Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
              850 855 860
           <![CDATA[ <210> 99]]>
           <![CDATA[ <211> 288]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 99]]>
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro
          1 5 10 15
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro
                      20 25 30
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro
                  35 40 45
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Ser Thr
              50 55 60
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr
          65 70 75 80
          Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                          85 90 95
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu
                      100 105 110
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr
                  115 120 125
          Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
              130 135 140
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu
          145 150 155 160
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Ser Glu Ser Ala Thr Pro
                          165 170 175
          Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                      180 185 190
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro
                  195 200 205
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr
              210 215 220
          Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala Pro
          225 230 235 240
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro
                          245 250 255
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro
                      260 265 270
          Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
                  275 280 285
           <![CDATA[ <210> 100]]>
           <![CDATA[ <211> 23]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 100]]>
          Met Lys Lys Asn Ile Ala Phe Leu Leu Ala Ser Met Phe Val Phe Ser
          1 5 10 15
          Ile Ala Thr Asn Ala Tyr Ala
                      20
           <![CDATA[ <210> 101]]>
           <![CDATA[ <211> 109]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 101]]>
          Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly
          1 5 10 15
          Thr Val Thr Leu Thr Cys Arg Ser Ser Asn Gly Ala Val Thr Ser Ser
                      20 25 30
          Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly
                  35 40 45
          Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe
              50 55 60
          Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val
          65 70 75 80
          Gln Pro Glu Asp Glu Ala Val Tyr Tyr Cys Ala Leu Trp Tyr Pro Asn
                          85 90 95
          Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
                      100 105
           <![CDATA[ <210> 102]]>
           <![CDATA[ <211> 125]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 102]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Ile Val Gln Pro Gly Gly
          1 5 10 15
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr
                      20 25 30
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
                  35 40 45
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp
              50 55 60
          Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
          65 70 75 80
          Val Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr
                          85 90 95
          Tyr Cys Val Arg His Glu Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe
                      100 105 110
          Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                  115 120 125
           <![CDATA[ <210> 103]]>
           <![CDATA[ <211> 109]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 103]]>
          Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly
          1 5 10 15
          Thr Val Thr Leu Thr Cys Arg Ser Ser Asn Gly Glu Val Thr Thr Ser
                      20 25 30
          Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly
                  35 40 45
          Leu Ile Gly Gly Thr Ile Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe
              50 55 60
          Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val
          65 70 75 80
          Gln Pro Glu Asp Glu Ala Val Tyr Tyr Cys Ala Leu Trp Tyr Pro Asn
                          85 90 95
          Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
                      100 105
           <![CDATA[ <210> 104]]>
           <![CDATA[ <211> 109]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 104]]>
          Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly
          1 5 10 15
          Thr Val Thr Leu Thr Cys Arg Ser Ser Asn Gly Ala Val Thr Ser Ser
                      20 25 30
          Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly
                  35 40 45
          Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe
              50 55 60
          Ser Gly Ser Ser Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val
          65 70 75 80
          Gln Pro Glu Asp Glu Ala Val Tyr Tyr Cys Ala Leu Trp Tyr Pro Asn
                          85 90 95
          Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
                      100 105
           <![CDATA[ <210> 105]]>
           <![CDATA[ <211> 125]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 105]]>
          Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Ile Val Gln Pro Gly Gly
          1 5 10 15
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr
                      20 25 30
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
                  35 40 45
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp
              50 55 60
          Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
          65 70 75 80
          Val Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr
                          85 90 95
          Tyr Cys Val Arg His Glu Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe
                      100 105 110
          Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                  115 120 125
           <![CDATA[ <210> 106]]>
           <![CDATA[ <211> 109]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 106]]>
          Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly
          1 5 10 15
          Thr Val Thr Leu Thr Cys Arg Ser Ser Asn Gly Ala Val Thr Ser Ser
                      20 25 30
          Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly
                  35 40 45
          Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe
              50 55 60
          Ser Gly Ser Leu Leu Gly Gly Ser Ala Ala Leu Thr Leu Ser Gly Val
          65 70 75 80
          Gln Pro Glu Asp Glu Ala Val Tyr Tyr Cys Ala Leu Trp Tyr Pro Asn
                          85 90 95
          Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
                      100 105
           <![CDATA[ <210> 107]]>
           <![CDATA[ <211> 109]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 107]]>
          Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly
          1 5 10 15
          Thr Val Thr Leu Thr Cys Arg Ser Ser Asn Gly Ala Val Thr Ser Ser
                      20 25 30
          Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly
                  35 40 45
          Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe
              50 55 60
          Ser Gly Ser Ser Leu Gly Gly Ser Ala Ala Leu Thr Leu Ser Gly Val
          65 70 75 80
          Gln Pro Glu Asp Glu Ala Val Tyr Tyr Cys Ala Leu Trp Tyr Pro Asn
                          85 90 95
          Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
                      100 105
           <![CDATA[ <210> 108]]>
           <![CDATA[ <211> 109]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 108]]>
          Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly
          1 5 10 15
          Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser
                      20 25 30
          Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly
                  35 40 45
          Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe
              50 55 60
          Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val
          65 70 75 80
          Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn
                          85 90 95
          Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
                      100 105
           <![CDATA[ <210> 109]]>
           <![CDATA[ <211> 125]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 109]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
          1 5 10 15
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr
                      20 25 30
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
                  35 40 45
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp
              50 55 60
          Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
          65 70 75 80
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr
                          85 90 95
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe
                      100 105 110
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                  115 120 125
           <![CDATA[ <210> 110]]>
           <![CDATA[ <211> 109]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 110]]>
          Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly
          1 5 10 15
          Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser
                      20 25 30
          Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly
                  35 40 45
          Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe
              50 55 60
          Ser Gly Ser Ser Leu Gly Gly Ser Ala Ala Leu Thr Leu Ser Gly Val
          65 70 75 80
          Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn
                          85 90 95
          Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
                      100 105
           <![CDATA[ <210> 111]]>
           <![CDATA[ <211> 125]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 111]]>
          Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
          1 5 10 15
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr
                      20 25 30
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
                  35 40 45
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp
              50 55 60
          Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
          65 70 75 80
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr
                          85 90 95
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe
                      100 105 110
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                  115 120 125
           <![CDATA[ <210> 112]]>
           <![CDATA[ <211> 15]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 112]]>
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          1 5 10 15
           <![CDATA[ <210> 113]]>
           <![CDATA[ <211> 18]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 113]]>
          Gly Glu Gly Thr Ser Thr Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly
          1 5 10 15
          Ala Asp
           <![CDATA[ <210> 114]]>
           <![CDATA[ <211> 18]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 114]]>
          Val Glu Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly
          1 5 10 15
          Val Asp
           <![CDATA[ <210> 115]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 115]]>
          Arg Thr Ser Gly Pro Gly Asp Gly Gly Lys Gly Gly Pro Gly Lys Gly
          1 5 10 15
          Pro Gly Gly Glu Gly Thr Lys Gly Thr Gly Pro Gly Gly
                      20 25
           <![CDATA[ <210> 116]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 116]]>
          Gly Ser Gly Glu Gly Ser Glu Gly Glu Gly Gly Gly Gly Glu Gly Ser Glu
          1 5 10 15
          Gly Glu Gly Ser Gly Glu Gly Gly Glu Gly Glu Gly Ser Gly
                      20 25 30
           <![CDATA[ <210> 117]]>
           <![CDATA[ <211> 32]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 117]]>
          Thr Gly Ser Gly Glu Gly Ser Glu Gly Glu Gly Gly Gly Glu Gly Ser
          1 5 10 15
          Glu Gly Glu Gly Ser Gly Glu Gly Gly Glu Gly Glu Gly Ser Gly Thr
                      20 25 30
           <![CDATA[ <210> 118]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 118]]>
          Gly Ala Thr Pro Pro Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly Glu
          1 5 10 15
          Thr Thr Gly Gly Ser Ala Glu Ser Glu Pro Pro Gly Glu Gly
                      20 25 30
           <![CDATA[ <210> 119]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 119]]>
          Gly Ser Ala Ala Pro Thr Ala Gly Thr Thr Pro Ser Ala Ser Pro Ala
          1 5 10 15
          Pro Pro Thr Gly Gly Ser Ser Ala Ala Gly Ser Pro Ser Thr
                      20 25 30
           <![CDATA[ <210> 120]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 120]]>
          Gly Glu Gly Gly Glu Ser Gly Gly Ser Glu Gly Glu Gly Ser Gly Glu
          1 5 10 15
          Gly Glu Gly Gly Ser Gly Gly Glu Gly Glu Ser Glu Gly Gly
                      20 25 30
           <![CDATA[ <210> 121]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 121]]>
          Ser Thr Glu Thr Ser Pro Ser Thr Pro Thr Glu Ser Pro Glu Ala Gly
          1 5 10 15
          Ser Gly Ser Gly Ser Pro Glu Ser Pro Ser Gly Thr Glu Ala
                      20 25 30
           <![CDATA[ <210> 122]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 122]]>
          Pro Thr Gly Thr Thr Gly Glu Pro Ser Gly Glu Gly Ser Glu Pro Glu
          1 5 10 15
          Gly Ser Ala Pro Thr Ser Ser Thr Ser Glu Ala Thr Pro Ser
                      20 25 30
           <![CDATA[ <210> 123]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 123]]>
          Ser Glu Ser Glu Ser Glu Gly Glu Ala Pro Thr Gly Pro Gly Ala Ser
          1 5 10 15
          Thr Thr Pro Glu Pro Ser Glu Ser Pro Thr Pro Glu Thr Ser
                      20 25 30
           <![CDATA[ <210> 124]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 124]]>
          Pro Glu Gly Gly Glu Ser Gly Glu Gly Thr Gly Pro Gly Thr Gly Gly
          1 5 10 15
          Glu Pro Glu Gly Glu Gly Gly Pro Gly Gly Glu Gly Gly Thr
                      20 25 30
           <![CDATA[ <210> 125]]>
           <![CDATA[ <211> 5]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 125]]>
          Ser Ala Thr Pro Glu
          1 5
           <![CDATA[ <210> 126]]>
           <![CDATA[ <211> 13]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 126]]>
          Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu
          1 5 10
           <![CDATA[ <210> 127]]>
           <![CDATA[ <211> 12]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 127]]>
          Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu
          1 5 10
           <![CDATA[ <210> 128]]>
           <![CDATA[ <211> 6]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 128]]>
          Thr Pro Gly Thr Ser Glu
          1 5
           <![CDATA[ <210> 129]]>
           <![CDATA[ <211> 11]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 129]]>
          Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu
          1 5 10
           <![CDATA[ <210> 130]]>
           <![CDATA[ <211> 8]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 130]]>
          Gly Ser Ala Pro Gly Thr Ser Glu
          1 5
           <![CDATA[ <210> 131]]>
           <![CDATA[ <211> 8]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 131]]>
          Gly Thr Ser Thr Glu Pro Ser Glu
          1 5
           <![CDATA[ <210> 132]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 132]]>
          Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
          1 5 10 15
           <![CDATA[ <210> 133]]>
           <![CDATA[ <211> 12]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 133]]>
          Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
          1 5 10
           <![CDATA[ <210> 134]]>
           <![CDATA[ <211> 7]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 134]]>
          Ser Gly Pro Gly Thr Ser Glu
          1 5
           <![CDATA[ <210> 135]]>
           <![CDATA[ <211> 15]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 135]]>
          Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
          1 5 10 15
           <![CDATA[ <210> 136]]>
           <![CDATA[ <211> 12]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 136]]>
          Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu
          1 5 10
           <![CDATA[ <210> 137]]>
           <![CDATA[ <211> 14]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 137]]>
          Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
          1 5 10
           <![CDATA[ <210> 138]]>
           <![CDATA[ <211> 14]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 138]]>
          Gly Ser Ala Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu
          1 5 10
           <![CDATA[ <210> 139]]>
           <![CDATA[ <211> 10]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 139]]>
          Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu
          1 5 10
           <![CDATA[ <210> 140]]>
           <![CDATA[ <211> 10]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 140]]>
          Ser Pro Ala Thr Ser Gly Ser Thr Pro Glu
          1 5 10
           <![CDATA[ <210> 141]]>
           <![CDATA[ <211> 8]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 141]]>
          Gly Ser Ala Pro Ala Thr Ser Glu
          1 5
           <![CDATA[ <210> 142]]>
           <![CDATA[ <211> 9]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 142]]>
          Gly Ser Ala Pro Gly Thr Ala Thr Glu
          1 5
           <![CDATA[ <210> 143]]>
           <![CDATA[ <211> 7]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 143]]>
          Gly Ser Ala Pro Gly Thr Glu
          1 5
           <![CDATA[ <210> 144]]>
           <![CDATA[ <211> 8]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 144]]>
          Pro Ala Thr Ser Gly Pro Thr Glu
          1 5
           <![CDATA[ <210> 145]]>
           <![CDATA[ <211> 5]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 145]]>
          Ser Ala Ser Pro Glu
          1 5
           <![CDATA[ <210> 146]]>
           <![CDATA[ <211> 8]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 146]]>
          Pro Ala Thr Ser Gly Ser Thr Glu
          1 5
           <![CDATA[ <210> 147]]>
           <![CDATA[ <211> 9]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 147]]>
          Gly Ser Ala Pro Gly Thr Ser Ala Glu
          1 5
           <![CDATA[ <210> 148]]>
           <![CDATA[ <211> 7]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 148]]>
          Ser Ala Thr Ser Ser Gly Ser Glu
          1 5
           <![CDATA[ <210> 149]]>
           <![CDATA[ <211> 9]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 149]]>
          Ser Gly Pro Gly Ser Thr Pro Ala Glu
          1 5
           <![CDATA[ <210> 150]]>
           <![CDATA[ <211> 13]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 150]]>
          Ser Gly Pro Gly Ser Thr Pro Ala Glu Ser Gly Ser Glu
          1 5 10
           <![CDATA[ <210> 151]]>
           <![CDATA[ <211> 15]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 151]]>
          Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Ser Gly Thr Ser Glu
          1 5 10 15
           <![CDATA[ <210> 152]]>
           <![CDATA[ <400> 152]]>
          000
           <![CDATA[ <210> 153]]>
           <![CDATA[ <400> 153]]>
          000
           <![CDATA[ <210> 154]]>
           <![CDATA[ <400> 154]]>
          000
           <![CDATA[ <210> 155]]>
           <![CDATA[ <400> 155]]>
          000
           <![CDATA[ <210> 156]]>
           <![CDATA[ <400> 156]]>
          000
           <![CDATA[ <210> 157]]>
           <![CDATA[ <400> 157]]>
          000
           <![CDATA[ <210> 158]]>
           <![CDATA[ <400> 158]]>
          000
           <![CDATA[ <210> 159]]>
           <![CDATA[ <400> 159]]>
          000
           <![CDATA[ <210> 160]]>
           <![CDATA[ <400> 160]]>
          000
           <![CDATA[ <210> 161]]>
           <![CDATA[ <400> 161]]>
          000
           <![CDATA[ <210> 162]]>
           <![CDATA[ <400> 162]]>
          000
           <![CDATA[ <210> 163]]>
           <![CDATA[ <400> 163]]>
          000
           <![CDATA[ <210> 164]]>
           <![CDATA[ <400> 164]]>
          000
           <![CDATA[ <210> 165]]>
           <![CDATA[ <400> 165]]>
          000
           <![CDATA[ <210> 166]]>
           <![CDATA[ <400> 166]]>
          000
           <![CDATA[ <210> 167]]>
           <![CDATA[ <400> 167]]>
          000
           <![CDATA[ <210> 168]]>
           <![CDATA[ <400> 168]]>
          000
           <![CDATA[ <210> 169]]>
           <![CDATA[ <400> 169]]>
          000
           <![CDATA[ <210> 170]]>
           <![CDATA[ <400> 170]]>
          000
           <![CDATA[ <210> 171]]>
           <![CDATA[ <400> 171]]>
          000
           <![CDATA[ <210> 172]]>
           <![CDATA[ <400> 172]]>
          000
           <![CDATA[ <210> 173]]>
           <![CDATA[ <400> 173]]>
          000
           <![CDATA[ <210> 174]]>
           <![CDATA[ <400> 174]]>
          000
           <![CDATA[ <210> 175]]>
           <![CDATA[ <400> 175]]>
          000
           <![CDATA[ <210> 176]]>
           <![CDATA[ <400> 176]]>
          000
           <![CDATA[ <210> 177]]>
           <![CDATA[ <400> 177]]>
          000
           <![CDATA[ <210> 178]]>
           <![CDATA[ <400> 178]]>
          000
           <![CDATA[ <210> 179]]>
           <![CDATA[ <211> 12]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 179]]>
          Gly Ser Glu Thr Pro Ser Gly Pro Ser Glu Thr Ala
          1 5 10
           <![CDATA[ <210> 180]]>
           <![CDATA[ <211> 12]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 180]]>
          Gly Pro Ser Glu Thr Ser Thr Ser Glu Pro Gly Ala
          1 5 10
           <![CDATA[ <210> 181]]>
           <![CDATA[ <211> 12]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 181]]>
          Gly Ser Pro Ser Glu Pro Thr Glu Gly Thr Ser Ala
          1 5 10
           <![CDATA[ <210> 182]]>
           <![CDATA[ <211> 12]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 182]]>
          Gly Glu Ser Pro Gly Gly Ser Ser Gly Ser Glu Ser
          1 5 10
           <![CDATA[ <210> 183]]>
           <![CDATA[ <211> 12]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 183]]>
          Gly Ser Glu Gly Ser Ser Gly Pro Gly Glu Ser Ser
          1 5 10
           <![CDATA[ <210> 184]]>
           <![CDATA[ <211> 12]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 184]]>
          Gly Ser Ser Glu Ser Ser Gly Ser Ser Glu Gly Gly Pro
          1 5 10
           <![CDATA[ <210> 185]]>
           <![CDATA[ <211> 12]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 185]]>
          Gly Ser Gly Gly Glu Pro Ser Glu Ser Gly Ser Ser
          1 5 10
           <![CDATA[ <210> 186]]>
           <![CDATA[ <211> 12]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 186]]>
          Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
          1 5 10
           <![CDATA[ <210> 187]]>
           <![CDATA[ <211> 12]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 187]]>
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro
          1 5 10
           <![CDATA[ <210> 188]]>
           <![CDATA[ <211> 12]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 188]]>
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
          1 5 10
           <![CDATA[ <210> 189]]>
           <![CDATA[ <211> 12]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 189]]>
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
          1 5 10
           <![CDATA[ <210> 190]]>
           <![CDATA[ <211> 12]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 190]]>
          Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro
          1 5 10
           <![CDATA[ <210> 191]]>
           <![CDATA[ <211> 12]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 191]]>
          Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro
          1 5 10
           <![CDATA[ <210> 192]]>
           <![CDATA[ <211> 12]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 192]]>
          Gly Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro
          1 5 10
           <![CDATA[ <210> 193]]>
           <![CDATA[ <211> 12]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 193]]>
          Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro
          1 5 10
           <![CDATA[ <210> 194]]>
           <![CDATA[ <211> 12]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 194]]>
          Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro
          1 5 10
           <![CDATA[ <210> 195]]>
           <![CDATA[ <211> 12]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 195]]>
          Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro
          1 5 10
           <![CDATA[ <210> 196]]>
           <![CDATA[ <211> 12]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 196]]>
          Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro
          1 5 10
           <![CDATA[ <210> 197]]>
           <![CDATA[ <211> 12]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 197]]>
          Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro
          1 5 10
           <![CDATA[ <210> 198]]>
           <![CDATA[ <211> 12]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 198]]>
          Gly Glu Pro Ala Gly Ser Pro Thr Ser Thr Ser Glu
          1 5 10
           <![CDATA[ <210> 199]]>
           <![CDATA[ <211> 12]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 199]]>
          Gly Thr Gly Glu Pro Ser Ser Thr Pro Ala Ser Glu
          1 5 10
           <![CDATA[ <210> 200]]>
           <![CDATA[ <211> 12]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 200]]>
          Gly Ser Gly Pro Ser Thr Glu Ser Ala Pro Thr Glu
          1 5 10
           <![CDATA[ <210> 201]]>
           <![CDATA[ <211> 264]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 201]]>
          Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly
          1 5 10 15
          Thr Val Thr Leu Thr Cys Arg Ser Ser Asn Gly Ala Val Thr Ser Ser
                      20 25 30
          Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly
                  35 40 45
          Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe
              50 55 60
          Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val
          65 70 75 80
          Gln Pro Glu Asp Glu Ala Val Tyr Tyr Cys Ala Leu Trp Tyr Pro Asn
                          85 90 95
          Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ala Thr
                      100 105 110
          Pro Pro Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly Glu Thr Thr Gly
                  115 120 125
          Gly Ser Ala Glu Ser Glu Pro Pro Gly Glu Gly Glu Val Gln Leu Leu
              130 135 140
          Glu Ser Gly Gly Gly Ile Val Gln Pro Gly Gly Ser Leu Lys Leu Ser
          145 150 155 160
          Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr Ala Met Asn Trp Val
                          165 170 175
          Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser
                      180 185 190
          Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg
                  195 200 205
          Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Val Tyr Leu Gln Met
              210 215 220
          Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His
          225 230 235 240
          Glu Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His Trp Gly Gln
                          245 250 255
          Gly Thr Leu Val Thr Val Ser Ser
                      260
           <![CDATA[ <210> 202]]>
           <![CDATA[ <211> 264]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 202]]>
          Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly
          1 5 10 15
          Thr Val Thr Leu Thr Cys Arg Ser Ser Asn Gly Glu Val Thr Thr Ser
                      20 25 30
          Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly
                  35 40 45
          Leu Ile Gly Gly Thr Ile Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe
              50 55 60
          Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val
          65 70 75 80
          Gln Pro Glu Asp Glu Ala Val Tyr Tyr Cys Ala Leu Trp Tyr Pro Asn
                          85 90 95
          Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ala Thr
                      100 105 110
          Pro Pro Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly Glu Thr Thr Gly
                  115 120 125
          Gly Ser Ala Glu Ser Glu Pro Pro Gly Glu Gly Glu Val Gln Leu Leu
              130 135 140
          Glu Ser Gly Gly Gly Ile Val Gln Pro Gly Gly Ser Leu Lys Leu Ser
          145 150 155 160
          Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr Ala Met Asn Trp Val
                          165 170 175
          Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser
                      180 185 190
          Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg
                  195 200 205
          Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Val Tyr Leu Gln Met
              210 215 220
          Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His
          225 230 235 240
          Glu Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His Trp Gly Gln
                          245 250 255
          Gly Thr Leu Val Thr Val Ser Ser
                      260
           <![CDATA[ <210> 203]]>
           <![CDATA[ <211> 264]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 203]]>
          Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly
          1 5 10 15
          Thr Val Thr Leu Thr Cys Arg Ser Ser Asn Gly Ala Val Thr Ser Ser
                      20 25 30
          Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly
                  35 40 45
          Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe
              50 55 60
          Ser Gly Ser Ser Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val
          65 70 75 80
          Gln Pro Glu Asp Glu Ala Val Tyr Tyr Cys Ala Leu Trp Tyr Pro Asn
                          85 90 95
          Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ala Thr
                      100 105 110
          Pro Pro Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly Glu Thr Thr Gly
                  115 120 125
          Gly Ser Ala Glu Ser Glu Pro Pro Gly Glu Gly Glu Val Gln Leu Gln
              130 135 140
          Glu Ser Gly Gly Gly Ile Val Gln Pro Gly Gly Ser Leu Lys Leu Ser
          145 150 155 160
          Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr Ala Met Asn Trp Val
                          165 170 175
          Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser
                      180 185 190
          Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg
                  195 200 205
          Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Val Tyr Leu Gln Met
              210 215 220
          Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His
          225 230 235 240
          Glu Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His Trp Gly Gln
                          245 250 255
          Gly Thr Leu Val Thr Val Ser Ser
                      260
           <![CDATA[ <210> 204]]>
           <![CDATA[ <211> 264]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 204]]>
          Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly
          1 5 10 15
          Thr Val Thr Leu Thr Cys Arg Ser Ser Asn Gly Ala Val Thr Ser Ser
                      20 25 30
          Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly
                  35 40 45
          Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe
              50 55 60
          Ser Gly Ser Leu Leu Gly Gly Ser Ala Ala Leu Thr Leu Ser Gly Val
          65 70 75 80
          Gln Pro Glu Asp Glu Ala Val Tyr Tyr Cys Ala Leu Trp Tyr Pro Asn
                          85 90 95
          Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ala Thr
                      100 105 110
          Pro Pro Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly Glu Thr Thr Gly
                  115 120 125
          Gly Ser Ala Glu Ser Glu Pro Pro Gly Glu Gly Glu Val Gln Leu Gln
              130 135 140
          Glu Ser Gly Gly Gly Ile Val Gln Pro Gly Gly Ser Leu Lys Leu Ser
          145 150 155 160
          Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr Ala Met Asn Trp Val
                          165 170 175
          Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser
                      180 185 190
          Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg
                  195 200 205
          Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Val Tyr Leu Gln Met
              210 215 220
          Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His
          225 230 235 240
          Glu Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His Trp Gly Gln
                          245 250 255
          Gly Thr Leu Val Thr Val Ser Ser
                      260
           <![CDATA[ <210> 205]]>
           <![CDATA[ <211> 264]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 205]]>
          Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly
          1 5 10 15
          Thr Val Thr Leu Thr Cys Arg Ser Ser Asn Gly Ala Val Thr Ser Ser
                      20 25 30
          Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly
                  35 40 45
          Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe
              50 55 60
          Ser Gly Ser Ser Leu Gly Gly Ser Ala Ala Leu Thr Leu Ser Gly Val
          65 70 75 80
          Gln Pro Glu Asp Glu Ala Val Tyr Tyr Cys Ala Leu Trp Tyr Pro Asn
                          85 90 95
          Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ala Thr
                      100 105 110
          Pro Pro Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly Glu Thr Thr Gly
                  115 120 125
          Gly Ser Ala Glu Ser Glu Pro Pro Gly Glu Gly Glu Val Gln Leu Gln
              130 135 140
          Glu Ser Gly Gly Gly Ile Val Gln Pro Gly Gly Ser Leu Lys Leu Ser
          145 150 155 160
          Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr Ala Met Asn Trp Val
                          165 170 175
          Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser
                      180 185 190
          Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg
                  195 200 205
          Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Val Tyr Leu Gln Met
              210 215 220
          Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His
          225 230 235 240
          Glu Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala His Trp Gly Gln
                          245 250 255
          Gly Thr Leu Val Thr Val Ser Ser
                      260
           <![CDATA[ <210> 206]]>
           <![CDATA[ <211> 264]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 206]]>
          Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly
          1 5 10 15
          Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser
                      20 25 30
          Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly
                  35 40 45
          Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe
              50 55 60
          Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val
          65 70 75 80
          Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn
                          85 90 95
          Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ala Thr
                      100 105 110
          Pro Pro Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly Glu Thr Thr Gly
                  115 120 125
          Gly Ser Ala Glu Ser Glu Pro Pro Gly Glu Gly Glu Val Gln Leu Leu
              130 135 140
          Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser
          145 150 155 160
          Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr Ala Met Asn Trp Val
                          165 170 175
          Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser
                      180 185 190
          Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg
                  195 200 205
          Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met
              210 215 220
          Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His
          225 230 235 240
          Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr Trp Gly Gln
                          245 250 255
          Gly Thr Leu Val Thr Val Ser Ser
                      260
           <![CDATA[ <210> 207]]>
           <![CDATA[ <211> 264]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 207]]>
          Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly
          1 5 10 15
          Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser
                      20 25 30
          Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly
                  35 40 45
          Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe
              50 55 60
          Ser Gly Ser Ser Leu Gly Gly Ser Ala Ala Leu Thr Leu Ser Gly Val
          65 70 75 80
          Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn
                          85 90 95
          Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ala Thr
                      100 105 110
          Pro Pro Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly Glu Thr Thr Gly
                  115 120 125
          Gly Ser Ala Glu Ser Glu Pro Pro Gly Glu Gly Glu Val Gln Leu Gln
              130 135 140
          Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser
          145 150 155 160
          Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr Ala Met Asn Trp Val
                          165 170 175
          Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser
                      180 185 190
          Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg
                  195 200 205
          Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met
              210 215 220
          Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His
          225 230 235 240
          Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr Trp Gly Gln
                          245 250 255
          Gly Thr Leu Val Thr Val Ser Ser
                      260
           <![CDATA[ <210> 208]]>
           <![CDATA[ <211> 256]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 208]]>
          Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
          1 5 10 15
          Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn
                      20 25 30
          Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
                  35 40 45
          Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
              50 55 60
          Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
          65 70 75 80
          Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu
                          85 90 95
          Ser Gly Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly
                      100 105 110
          Ala Thr Pro Pro Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly Glu Thr
                  115 120 125
          Thr Gly Gly Ser Ala Glu Ser Glu Pro Pro Gly Glu Gly Gln Val Gln
              130 135 140
          Leu Gln Gln Trp Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg
          145 150 155 160
          Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ser Met Asn
                          165 170 175
          Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Arg Ile
                      180 185 190
          Asn Ser Asp Gly Ser Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg
                  195 200 205
          Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met
              210 215 220
          Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu
          225 230 235 240
          Leu Arg Trp Gly Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                          245 250 255
           <![CDATA[ <210> 209]]>
           <![CDATA[ <211> 255]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 209]]>
          Gln Ala Gly Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
          1 5 10 15
          Arg Val Thr Leu Ser Cys Ser Gly Ser Tyr Ser Asn Ile Gly Thr Tyr
                      20 25 30
          Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
                  35 40 45
          Ile Tyr Ser Asn Asp Gln Arg Leu Ser Gly Val Pro Asp Arg Phe Ser
              50 55 60
          Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
          65 70 75 80
          Ser Glu Asp Glu Ala Ala Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu
                          85 90 95
          Asn Gly Trp Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ala
                      100 105 110
          Thr Pro Pro Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly Glu Thr Thr
                  115 120 125
          Gly Gly Ser Ala Glu Ser Glu Pro Pro Gly Glu Gly Gln Val Gln Leu
              130 135 140
          Gln Gln Trp Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu
          145 150 155 160
          Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ser Met Asn Trp
                          165 170 175
          Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Arg Ile Asn
                      180 185 190
          Ser Asp Gly Ser Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe
                  195 200 205
          Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn
              210 215 220
          Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Leu
          225 230 235 240
          Arg Trp Gly Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                          245 250 255
           <![CDATA[ <210> 210]]>
           <![CDATA[ <211> 255]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 210]]>
          Gln Pro Gly Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
          1 5 10 15
          Arg Val Thr Leu Ser Cys Ser Gly Arg Ser Ser Asn Ile Gly Ser Tyr
                      20 25 30
          Tyr Val Tyr Trp Tyr Gln His Leu Pro Gly Met Ala Pro Lys Leu Leu
                  35 40 45
          Ile Tyr Arg Asn Ser Arg Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
              50 55 60
          Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Val Ile Ser Gly Leu Gln
          65 70 75 80
          Ser Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu
                          85 90 95
          Lys Ser Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ala
                      100 105 110
          Thr Pro Pro Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly Glu Thr Thr
                  115 120 125
          Gly Gly Ser Ala Glu Ser Glu Pro Pro Gly Glu Gly Gln Val Gln Leu
              130 135 140
          Gln Gln Trp Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu
          145 150 155 160
          Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ser Met Asn Trp
                          165 170 175
          Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Arg Ile Asn
                      180 185 190
          Ser Asp Gly Ser Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe
                  195 200 205
          Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn
              210 215 220
          Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Leu
          225 230 235 240
          Arg Trp Gly Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                          245 250 255
           <![CDATA[ <210> 211]]>
           <![CDATA[ <211> 255]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 211]]>
          Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
          1 5 10 15
          Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Thr Asn
                      20 25 30
          Tyr Val Tyr Trp Tyr Gln Gln Phe Pro Gly Thr Ala Pro Lys Leu Leu
                  35 40 45
          Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
              50 55 60
          Gly Ser Lys Ser Gly Thr Ser Gly Ser Leu Ala Ile Ser Gly Leu Gln
          65 70 75 80
          Ser Glu Asp Glu Ala Asp Tyr Ser Cys Ala Ala Trp Asp Asp Ser Leu
                          85 90 95
          Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ala
                      100 105 110
          Thr Pro Pro Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly Glu Thr Thr
                  115 120 125
          Gly Gly Ser Ala Glu Ser Glu Pro Pro Gly Glu Gly Gln Val Gln Leu
              130 135 140
          Val Gln Trp Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu
          145 150 155 160
          Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ser Met Asn Trp
                          165 170 175
          Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Arg Ile Asn
                      180 185 190
          Ser Asp Gly Ser Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe
                  195 200 205
          Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn
              210 215 220
          Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Leu
          225 230 235 240
          Arg Trp Gly Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                          245 250 255
           <![CDATA[ <210> 212]]>
           <![CDATA[ <211> 255]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 212]]>
          Gln Pro Gly Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
          1 5 10 15
          Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn
                      20 25 30
          Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
                  35 40 45
          Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Leu Ser
              50 55 60
          Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
          65 70 75 80
          Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu
                          85 90 95
          Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ala
                      100 105 110
          Thr Pro Pro Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly Glu Thr Thr
                  115 120 125
          Gly Gly Ser Ala Glu Ser Glu Pro Pro Gly Glu Gly Gln Val Gln Leu
              130 135 140
          Val Gln Trp Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu
          145 150 155 160
          Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ser Met Asn Trp
                          165 170 175
          Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Arg Ile Asn
                      180 185 190
          Ser Asp Gly Ser Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe
                  195 200 205
          Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn
              210 215 220
          Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Leu
          225 230 235 240
          Arg Trp Gly Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                          245 250 255
           <![CDATA[ <210> 213]]>
           <![CDATA[ <211> 256]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 213]]>
          Gln Ala Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
          1 5 10 15
          Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Tyr
                      20 25 30
          Tyr Val Tyr Trp Tyr Gln Gln Val Pro Gly Ala Ala Pro Lys Leu Leu
                  35 40 45
          Met Arg Leu Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
              50 55 60
          Gly Ala Lys Ser Gly Thr Ser Ala Ser Leu Val Ile Ser Gly Leu Arg
          65 70 75 80
          Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu
                          85 90 95
          Ser Gly Gln Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly
                      100 105 110
          Ala Thr Pro Pro Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly Glu Thr
                  115 120 125
          Thr Gly Gly Ser Ala Glu Ser Glu Pro Pro Gly Glu Gly Gln Val Gln
              130 135 140
          Leu Gln Gln Trp Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg
          145 150 155 160
          Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ser Met Asn
                          165 170 175
          Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Arg Ile
                      180 185 190
          Asn Ser Asp Gly Ser Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg
                  195 200 205
          Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met
              210 215 220
          Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu
          225 230 235 240
          Leu Arg Trp Gly Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                          245 250 255
           <![CDATA[ <210> 214]]>
           <![CDATA[ <211> 255]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 214]]>
          Gln Ala Gly Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
          1 5 10 15
          Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn
                      20 25 30
          Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
                  35 40 45
          Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
              50 55 60
          Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
          65 70 75 80
          Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Ala Ser Leu
                          85 90 95
          Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ala
                      100 105 110
          Thr Pro Pro Glu Thr Gly Ala Glu Thr Glu Ser Pro Gly Glu Thr Thr
                  115 120 125
          Gly Gly Ser Ala Glu Ser Glu Pro Pro Gly Glu Gly Glu Val Gln Leu
              130 135 140
          Val Gln Trp Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu
          145 150 155 160
          Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ser Met Asn Trp
                          165 170 175
          Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Arg Ile Asn
                      180 185 190
          Ser Asp Gly Ser Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe
                  195 200 205
          Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn
              210 215 220
          Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Leu
          225 230 235 240
          Arg Trp Gly Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                          245 250 255
           <![CDATA[ <210> 215]]>
           <![CDATA[ <400> 215]]>
          000
           <![CDATA[ <210> 216]]>
           <![CDATA[ <400> 216]]>
          000
           <![CDATA[ <210> 217]]>
           <![CDATA[ <400> 217]]>
          000
           <![CDATA[ <210> 218]]>
           <![CDATA[ <400> 218]]>
          000
           <![CDATA[ <210> 219]]>
           <![CDATA[ <400> 219]]>
          000
           <![CDATA[ <210> 220]]>
           <![CDATA[ <400> 220]]>
          000
           <![CDATA[ <210> 221]]>
           <![CDATA[ <400> 221]]>
          000
           <![CDATA[ <210> 222]]>
           <![CDATA[ <211> 8]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 222]]>
          Leu Thr Pro Arg Ser Leu Leu Val
          1 5
           <![CDATA[ <210> 223]]>
           <![CDATA[ <400> 223]]>
          000
           <![CDATA[ <210> 224]]>
           <![CDATA[ <211> 8]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 224]]>
          Lys Leu Thr Arg Val Val Gly Gly
          1 5
           <![CDATA[ <210> 225]]>
           <![CDATA[ <211> 8]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 225]]>
          Thr Met Thr Arg Ile Val Gly Gly
          1 5
           <![CDATA[ <210> 226]]>
           <![CDATA[ <211> 8]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 226]]>
          Ser Pro Phe Arg Ser Thr Gly Gly
          1 5
           <![CDATA[ <210> 227]]>
           <![CDATA[ <211> 8]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 227]]>
          Leu Gln Val Arg Ile Val Gly Gly
          1 5
           <![CDATA[ <210> 228]]>
           <![CDATA[ <211> 8]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 228]]>
          Pro Leu Gly Arg Ile Val Gly Gly
          1 5
           <![CDATA[ <210> 229]]>
           <![CDATA[ <211> 8]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 229]]>
          Ile Glu Gly Arg Thr Val Gly Gly
          1 5
           <![CDATA[ <210> 230]]>
           <![CDATA[ <211> 8]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 230]]>
          Leu Thr Pro Arg Ser Leu Leu Val
          1 5
           <![CDATA[ <210> 231]]>
           <![CDATA[ <211> 8]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 231]]>
          Leu Gly Pro Val Ser Gly Val Pro
          1 5
           <![CDATA[ <210> 232]]>
           <![CDATA[ <211> 8]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 232]]>
          Val Ala Gly Asp Ser Leu Glu Glu
          1 5
           <![CDATA[ <210> 233]]>
           <![CDATA[ <211> 8]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 233]]>
          Gly Pro Ala Gly Leu Gly Gly Ala
          1 5
           <![CDATA[ <210> 234]]>
           <![CDATA[ <211> 8]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 234]]>
          Gly Pro Ala Gly Leu Arg Gly Ala
          1 5
           <![CDATA[ <210> 235]]>
           <![CDATA[ <211> 8]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 235]]>
          Ala Pro Leu Gly Leu Arg Leu Arg
          1 5
           <![CDATA[ <210> 236]]>
           <![CDATA[ <211> 8]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 236]]>
          Pro Ala Leu Pro Leu Val Ala Gln
          1 5
           <![CDATA[ <210> 237]]>
           <![CDATA[ <211> 7]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 237]]>
          Glu Asn Leu Tyr Phe Gln Gly
          1 5
           <![CDATA[ <210> 238]]>
           <![CDATA[ <211> 8]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 238]]>
          Asp Asp Asp Lys Ile Val Gly Gly
          1 5
           <![CDATA[ <210> 239]]>
           <![CDATA[ <211> 8]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 239]]>
          Leu Glu Val Leu Phe Gln Gly Pro
          1 5
           <![CDATA[ <210> 240]]>
           <![CDATA[ <211> 8]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 240]]>
          Leu Pro Lys Thr Gly Ser Glu Ser
          1 5
           <![CDATA[ <210> 241]]>
           <![CDATA[ <211> 8]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> MISC_FEATURE]]>
           <![CDATA[ <222> (2)..(2)]]>
           <![CDATA[ <223> X is P or A]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> MISC_FEATURE]]>
           <![CDATA[ <222> (3)..(3)]]>
           <![CDATA[ <223> X is any amino acid]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> MISC_FEATURE]]>
           <![CDATA[ <222> (6)..(6)]]>
           <![CDATA[ <223> X is any amino acid]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> MISC_FEATURE]]>
           <![CDATA[ <222> (8)..(8)]]>
           <![CDATA[ <223> X is any amino acid]]>
           <![CDATA[ <400> 241]]>
          Gly Xaa Xaa Gly Leu Xaa Gly Xaa
          1 5
           <![CDATA[ <210> 242]]>
           <![CDATA[ <211> 8]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> MISC_FEATURE]]>
           <![CDATA[ <222> (3)..(3)]]>
           <![CDATA[ <223> X is any amino acid]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> MISC_FEATURE]]>
           <![CDATA[ <222> (6)..(6)]]>
           <![CDATA[ <223> X is any amino acid]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> MISC_FEATURE]]>
           <![CDATA[ <222> (7)..(7)]]>
           <![CDATA[ <223> X is G or A]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> MISC_FEATURE]]>
           <![CDATA[ <222> (8)..(8)]]>
           <![CDATA[ <223> X is any amino acid]]>
           <![CDATA[ <400> 242]]>
          Gly Pro Xaa Gly Leu Xaa Xaa Xaa
          1 5
           <![CDATA[ <210> 243]]>
           <![CDATA[ <211> 7]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> MISC_FEATURE]]>
           <![CDATA[ <222> (7)..(7)]]>
           <![CDATA[ <223> X is G or S]]>
           <![CDATA[ <400> 243]]>
          Glu Asn Leu Tyr Phe Gln Xaa
          1 5
           <![CDATA[ <210> 244]]>
           <![CDATA[ <211> 8]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> MISC_FEATURE]]>
           <![CDATA[ <222> (1)..(1)]]>
           <![CDATA[ <223> X is K or D]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> MISC_FEATURE]]>
           <![CDATA[ <222> (2)..(2)]]>
           <![CDATA[ <223> X is F or L]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> MISC_FEATURE]]>
           <![CDATA[ <222> (5)..(5)]]>
           <![CDATA[ <223> X is V or A]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> MISC_FEATURE]]>
           <![CDATA[ <222> (6)..(6)]]>
           <![CDATA[ <223> X is V or E]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> MISC_FEATURE]]>
           <![CDATA[ <222> (7)..(7)]]>
           <![CDATA[ <223> X is G or T]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> MISC_FEATURE]]>
           <![CDATA[ <222> (8)..(8)]]>
           <![CDATA[ <223> X is G or V]]>
           <![CDATA[ <400> 244]]>
          Xaa Xaa Thr Arg Xaa Xaa Xaa Xaa
          1 5
           <![CDATA[ <210> 245]]>
           <![CDATA[ <211> 8]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> MISC_FEATURE]]>
           <![CDATA[ <222> (1)..(2)]]>
           <![CDATA[ <223> X is any amino acid]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> MISC_FEATURE]]>
           <![CDATA[ <222> (3)..(3)]]>
           <![CDATA[ <223> X is F or L]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> MISC_FEATURE]]>
           <![CDATA[ <222> (4)..(4)]]>
           <![CDATA[ <223> X is R or Y]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> MISC_FEATURE]]>
           <![CDATA[ <222> (5)..(5)]]>
           <![CDATA[ <223> X is R or S]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> MISC_FEATURE]]>
           <![CDATA[ <222> (6)..(6)]]>
           <![CDATA[ <223> X is R or T]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> MISC_FEATURE]]>
           <![CDATA[ <222> (7)..(8)]]>
           <![CDATA[ <223> X is any amino acid]]>
           <![CDATA[ <400> 245]]>
          Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
          1 5
           <![CDATA[ <210> 246]]>
           <![CDATA[ <211> 8]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> MISC_FEATURE]]>
           <![CDATA[ <222> (3)..(3)]]>
           <![CDATA[ <223> X is K, E, A or D]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> MISC_FEATURE]]>
           <![CDATA[ <222> (6)..(6)]]>
           <![CDATA[ <223> X is any amino acid]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> MISC_FEATURE]]>
           <![CDATA[ <222> (7)..(7)]]>
           <![CDATA[ <223> X is K, E or S]]>
           <![CDATA[ <400> 246]]>
          Leu Pro Xaa Thr Gly Xaa Xaa Ser
          1 5
           <![CDATA[ <210> 247]]>
           <![CDATA[ <211> 8]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> MISC_FEATURE]]>
           <![CDATA[ <222> (1)..(2)]]>
           <![CDATA[ <223> X is any amino acid]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> MISC_FEATURE]]>
           <![CDATA[ <222> (5)..(8)]]>
           <![CDATA[ <223> X is any amino acid]]>
           <![CDATA[ <400> 247]]>
          Xaa Xaa Gly Arg Xaa Xaa Xaa Xaa
          1 5
           <![CDATA[ <210> 248]]>
           <![CDATA[ <211> 8]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> MISC_FEATURE]]>
           <![CDATA[ <222> (1)..(1)]]>
           <![CDATA[ <223> X is I or A]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> MISC_FEATURE]]>
           <![CDATA[ <222> (3)..(3)]]>
           <![CDATA[ <223> X is G, F or P]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> MISC_FEATURE]]>
           <![CDATA[ <222> (5)..(5)]]>
           <![CDATA[ <223> X is S, T or I]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> MISC_FEATURE]]>
           <![CDATA[ <222> (6)..(6)]]>
           <![CDATA[ <223> X is V, F or S]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> MISC_FEATURE]]>
           <![CDATA[ <222> (7)..(7)]]>
           <![CDATA[ <223> X is any amino acid]]>
           <![CDATA[ <400> 248]]>
          Xaa Glu Xaa Arg Xaa Xaa Xaa Gly
          1 5
           <![CDATA[ <210> 249]]>
           <![CDATA[ <211> 8]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> MISC_FEATURE]]>
           <![CDATA[ <222> (1)..(2)]]>
           <![CDATA[ <223> X is any amino acid]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> MISC_FEATURE]]>
           <![CDATA[ <222> (3)..(3)]]>
           <![CDATA[ <223> X is P, L or A]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> MISC_FEATURE]]>
           <![CDATA[ <222> (5)..(5)]]>
           <![CDATA[ <223> X is S, G or A]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> MISC_FEATURE]]>
           <![CDATA[ <222> (6)..(8)]]>
           <![CDATA[ <223> X is any amino acid]]>
           <![CDATA[ <400> 249]]>
          Xaa Xaa Xaa Arg Xaa Xaa Xaa Xaa
          1 5
           <![CDATA[ <210> 250]]>
           <![CDATA[ <211> 8]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> MISC_FEATURE]]>
           <![CDATA[ <222> (1)..(3)]]>
           <![CDATA[ <223> X is any amino acid]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> MISC_FEATURE]]>
           <![CDATA[ <222> (4)..(4)]]>
           <![CDATA[ <223> X is V, A, I or T]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> MISC_FEATURE]]>
           <![CDATA[ <222> (5)..(8)]]>
           <![CDATA[ <223> X is any amino acid]]>
           <![CDATA[ <400> 250]]>
          Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
          1 5
           <![CDATA[ <210> 251]]>
           <![CDATA[ <211> 8]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> MISC_FEATURE]]>
           <![CDATA[ <222> (2)..(3)]]>
           <![CDATA[ <223> X is any amino acid]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> MISC_FEATURE]]>
           <![CDATA[ <222> (5)..(8)]]>
           <![CDATA[ <223> X is any amino acid]]>
           <![CDATA[ <400> 251]]>
          Val Xaa Xaa Asp Xaa Xaa Xaa Xaa
          1 5
           <![CDATA[ <210> 252]]>
           <![CDATA[ <211> 8]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> MISC_FEATURE]]>
           <![CDATA[ <222> (1)..(1)]]>
           <![CDATA[ <223> X is any amino acid]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> MISC_FEATURE]]>
           <![CDATA[ <222> (2)..(2)]]>
           <![CDATA[ <223> X is P or S]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> MISC_FEATURE]]>
           <![CDATA[ <222> (3)..(4)]]>
           <![CDATA[ <223> X is any amino acid]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> MISC_FEATURE]]>
           <![CDATA[ <222> (5)..(5)]]>
           <![CDATA[ <223> X is L or Q]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> MISC_FEATURE]]>
           <![CDATA[ <222> (6)..(6)]]>
           <![CDATA[ <223> X is any amino acid]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> MISC_FEATURE]]>
           <![CDATA[ <222> (7)..(7)]]>
           <![CDATA[ <223> X is L or T]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <221> MISC_FEATURE]]>
           <![CDATA[ <222> (8)..(8)]]>
           <![CDATA[ <223> X is any amino acid]]>
           <![CDATA[ <400> 252]]>
          Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
          1 5
           <![CDATA[ <210> 253]]>
           <![CDATA[ <400> 253]]>
          000
           <![CDATA[ <210> 254]]>
           <![CDATA[ <400> 254]]>
          000
           <![CDATA[ <210> 255]]>
           <![CDATA[ <400> 255]]>
          000
           <![CDATA[ <210> 256]]>
           <![CDATA[ <400> 256]]>
          000
           <![CDATA[ <210> 257]]>
           <![CDATA[ <400> 257]]>
          000
           <![CDATA[ <210> 258]]>
           <![CDATA[ <400> 258]]>
          000
           <![CDATA[ <210> 259]]>
           <![CDATA[ <400> 259]]>
          000
           <![CDATA[ <210> 260]]>
           <![CDATA[ <400> 260]]>
          000
           <![CDATA[ <210> 261]]>
           <![CDATA[ <400> 261]]>
          000
           <![CDATA[ <210> 262]]>
           <![CDATA[ <400> 262]]>
          000
           <![CDATA[ <210> 263]]>
           <![CDATA[ <400> 263]]>
          000
           <![CDATA[ <210> 264]]>
           <![CDATA[ <400> 264]]>
          000
           <![CDATA[ <210> 265]]>
           <![CDATA[ <400> 265]]>
          000
           <![CDATA[ <210> 266]]>
           <![CDATA[ <400> 266]]>
          000
           <![CDATA[ <210> 267]]>
           <![CDATA[ <400> 267]]>
          000
           <![CDATA[ <210> 268]]>
           <![CDATA[ <400> 268]]>
          000
           <![CDATA[ <210> 269]]>
           <![CDATA[ <400> 269]]>
          000
           <![CDATA[ <210> 270]]>
           <![CDATA[ <400> 270]]>
          000
           <![CDATA[ <210> 271]]>
           <![CDATA[ <400> 271]]>
          000
           <![CDATA[ <210> 272]]>
           <![CDATA[ <400> 272]]>
          000
           <![CDATA[ <210> 273]]>
           <![CDATA[ <400> 273]]>
          000
           <![CDATA[ <210> 274]]>
           <![CDATA[ <400> 274]]>
          000
           <![CDATA[ <210> 275]]>
           <![CDATA[ <400> 275]]>
          000
           <![CDATA[ <210> 276]]>
           <![CDATA[ <400> 276]]>
          000
           <![CDATA[ <210> 277]]>
           <![CDATA[ <400> 277]]>
          000
           <![CDATA[ <210> 278]]>
           <![CDATA[ <400> 278]]>
          000
           <![CDATA[ <210> 279]]>
           <![CDATA[ <400> 279]]>
          000
           <![CDATA[ <210> 280]]>
           <![CDATA[ <400> 280]]>
          000
           <![CDATA[ <210> 281]]>
           <![CDATA[ <400> 281]]>
          000
           <![CDATA[ <210> 282]]>
           <![CDATA[ <400> 282]]>
          000
           <![CDATA[ <210> 283]]>
           <![CDATA[ <400> 283]]>
          000
           <![CDATA[ <210> 284]]>
           <![CDATA[ <400> 284]]>
          000
           <![CDATA[ <210> 285]]>
           <![CDATA[ <400> 285]]>
          000
           <![CDATA[ <210> 286]]>
           <![CDATA[ <400> 286]]>
          000
           <![CDATA[ <210> 287]]>
           <![CDATA[ <400> 287]]>
          000
           <![CDATA[ <210> 288]]>
           <![CDATA[ <400> 288]]>
          000
           <![CDATA[ <210> 289]]>
           <![CDATA[ <400> 289]]>
          000
           <![CDATA[ <210> 290]]>
           <![CDATA[ <400> 290]]>
          000
           <![CDATA[ <210> 291]]>
           <![CDATA[ <400> 291]]>
          000
           <![CDATA[ <210> 292]]>
           <![CDATA[ <400> 292]]>
          000
           <![CDATA[ <210> 293]]>
           <![CDATA[ <400> 293]]>
          000
           <![CDATA[ <210> 294]]>
           <![CDATA[ <400> 294]]>
          000
           <![CDATA[ <210> 295]]>
           <![CDATA[ <400> 295]]>
          000
           <![CDATA[ <210> 296]]>
           <![CDATA[ <400> 296]]>
          000
           <![CDATA[ <210> 297]]>
           <![CDATA[ <400> 297]]>
          000
           <![CDATA[ <210> 298]]>
           <![CDATA[ <400> 298]]>
          000
           <![CDATA[ <210> 299]]>
           <![CDATA[ <400> 299]]>
          000
           <![CDATA[ <210> 300]]>
           <![CDATA[ <400> 300]]>
          000
           <![CDATA[ <210> 301]]>
           <![CDATA[ <211> 119]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 301]]>
          Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg
          1 5 10 15
          Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr
                      20 25 30
          Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
                  35 40 45
          Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Val
              50 55 60
          Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ala Phe
          65 70 75 80
          Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys
                          85 90 95
          Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly
                      100 105 110
          Thr Pro Val Thr Val Ser Ser
                  115
           <![CDATA[ <210> 302]]>
           <![CDATA[ <211> 122]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 302]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
          1 5 10 15
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Phe Thr Gly Tyr
                      20 25 30
          Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
                  35 40 45
          Ala Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe
              50 55 60
          Lys Asp Arg Phe Thr Ile Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr
          65 70 75 80
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                          85 90 95
          Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp
                      100 105 110
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                  115 120
           <![CDATA[ <210> 303]]>
           <![CDATA[ <211> 119]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 303]]>
          Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg
          1 5 10 15
          Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
                      20 25 30
          Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
                  35 40 45
          Gly Tyr Ile Asn Pro Ser Ser Gly Tyr Thr Lys Tyr Asn Gln Lys Phe
              50 55 60
          Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe
          65 70 75 80
          Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys
                          85 90 95
          Ala Arg Trp Gln Asp Tyr Asp Val Tyr Phe Asp Tyr Trp Gly Gln Gly
                      100 105 110
          Thr Pro Val Thr Val Ser Ser
                  115
           <![CDATA[ <210> 304]]>
           <![CDATA[ <211> 119]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 304]]>
          Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala
          1 5 10 15
          Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr
                      20 25 30
          Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
                  35 40 45
          Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe
              50 55 60
          Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr
          65 70 75 80
          Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                          85 90 95
          Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly
                      100 105 110
          Thr Thr Leu Thr Val Ser Ser
                  115
           <![CDATA[ <210> 305]]>
           <![CDATA[ <211> 119]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 305]]>
          Asp Ile Lys Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala
          1 5 10 15
          Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Arg Tyr
                      20 25 30
          Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
                  35 40 45
          Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe
              50 55 60
          Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr
          65 70 75 80
          Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                          85 90 95
          Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly
                      100 105 110
          Thr Thr Leu Thr Val Ser Ser
                  115
           <![CDATA[ <210> 306]]>
           <![CDATA[ <211> 119]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 306]]>
          Asp Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
          1 5 10 15
          Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr
                      20 25 30
          Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile
                  35 40 45
          Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Ala Asp Ser Val
              50 55 60
          Lys Gly Arg Phe Thr Ile Thr Thr Asp Lys Ser Thr Ser Thr Ala Tyr
          65 70 75 80
          Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys
                          85 90 95
          Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly
                      100 105 110
          Thr Thr Val Thr Val Ser Ser
                  115
           <![CDATA[ <210> 307]]>
           <![CDATA[ <211> 125]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 307]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
          1 5 10 15
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr
                      20 25 30
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
                  35 40 45
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp
              50 55 60
          Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
          65 70 75 80
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr
                          85 90 95
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp
                      100 105 110
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                  115 120 125
           <![CDATA[ <210> 308]]>
           <![CDATA[ <211> 125]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 308]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
          1 5 10 15
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr
                      20 25 30
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
                  35 40 45
          Gly Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp
              50 55 60
          Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
          65 70 75 80
          Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                          85 90 95
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe
                      100 105 110
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                  115 120 125
           <![CDATA[ <210> 309]]>
           <![CDATA[ <211> 125]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 309]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
          1 5 10 15
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr
                      20 25 30
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
                  35 40 45
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp
              50 55 60
          Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
          65 70 75 80
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr
                          85 90 95
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe
                      100 105 110
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                  115 120 125
           <![CDATA[ <210> 310]]>
           <![CDATA[ <211> 125]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 310]]>
          Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly
          1 5 10 15
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr
                      20 25 30
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
                  35 40 45
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp
              50 55 60
          Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Ile
          65 70 75 80
          Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr
                          85 90 95
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe
                      100 105 110
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                  115 120 125
           <![CDATA[ <210> 311]]>
           <![CDATA[ <400> 311]]>
          000
           <![CDATA[ <210> 312]]>
           <![CDATA[ <400> 312]]>
          000
           <![CDATA[ <210> 313]]>
           <![CDATA[ <400> 313]]>
          000
           <![CDATA[ <210> 314]]>
           <![CDATA[ <400> 314]]>
          000
           <![CDATA[ <210> 315]]>
           <![CDATA[ <400> 315]]>
          000
           <![CDATA[ <210> 316]]>
           <![CDATA[ <400> 316]]>
          000
           <![CDATA[ <210> 317]]>
           <![CDATA[ <400> 317]]>
          000
           <![CDATA[ <210> 318]]>
           <![CDATA[ <400> 318]]>
          000
           <![CDATA[ <210> 319]]>
           <![CDATA[ <400> 319]]>
          000
           <![CDATA[ <210> 320]]>
           <![CDATA[ <400> 320]]>
          000
           <![CDATA[ <210> 321]]>
           <![CDATA[ <400> 321]]>
          000
           <![CDATA[ <210> 322]]>
           <![CDATA[ <400> 322]]>
          000
           <![CDATA[ <210> 323]]>
           <![CDATA[ <400> 323]]>
          000
           <![CDATA[ <210> 324]]>
           <![CDATA[ <400> 324]]>
          000
           <![CDATA[ <210> 325]]>
           <![CDATA[ <400> 325]]>
          000
           <![CDATA[ <210> 326]]>
           <![CDATA[ <400> 326]]>
          000
           <![CDATA[ <210> 327]]>
           <![CDATA[ <400> 327]]>
          000
           <![CDATA[ <210> 328]]>
           <![CDATA[ <400> 328]]>
          000
           <![CDATA[ <210> 329]]>
           <![CDATA[ <400> 329]]>
          000
           <![CDATA[ <210> 330]]>
           <![CDATA[ <400> 330]]>
          000
           <![CDATA[ <210> 331]]>
           <![CDATA[ <400> 331]]>
          000
           <![CDATA[ <210> 332]]>
           <![CDATA[ <400> 332]]>
          000
           <![CDATA[ <210> 333]]>
           <![CDATA[ <400> 333]]>
          000
           <![CDATA[ <210> 334]]>
           <![CDATA[ <400> 334]]>
          000
           <![CDATA[ <210> 335]]>
           <![CDATA[ <400> 335]]>
          000
           <![CDATA[ <210> 336]]>
           <![CDATA[ <400> 336]]>
          000
           <![CDATA[ <210> 337]]>
           <![CDATA[ <400> 337]]>
          000
           <![CDATA[ <210> 338]]>
           <![CDATA[ <400> 338]]>
          000
           <![CDATA[ <210> 339]]>
           <![CDATA[ <400> 339]]>
          000
           <![CDATA[ <210> 340]]>
           <![CDATA[ <400> 340]]>
          000
           <![CDATA[ <210> 341]]>
           <![CDATA[ <400> 341]]>
          000
           <![CDATA[ <210> 342]]>
           <![CDATA[ <400> 342]]>
          000
           <![CDATA[ <210> 343]]>
           <![CDATA[ <400> 343]]>
          000
           <![CDATA[ <210> 344]]>
           <![CDATA[ <400> 344]]>
          000
           <![CDATA[ <210> 345]]>
           <![CDATA[ <400> 345]]>
          000
           <![CDATA[ <210> 346]]>
           <![CDATA[ <400> 346]]>
          000
           <![CDATA[ <210> 347]]>
           <![CDATA[ <400> 347]]>
          000
           <![CDATA[ <210> 348]]>
           <![CDATA[ <400> 348]]>
          000
           <![CDATA[ <210> 349]]>
           <![CDATA[ <400> 349]]>
          000
           <![CDATA[ <210> 350]]>
           <![CDATA[ <400> 350]]>
          000
           <![CDATA[ <210> 351]]>
           <![CDATA[ <211> 107]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 351]]>
          Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
          1 5 10 15
          Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      20 25 30
          Asn Trp Tyr Gln Gln Thr Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr
                  35 40 45
          Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
              50 55 60
          Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu
          65 70 75 80
          Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr
                          85 90 95
          Phe Gly Gln Gly Thr Lys Leu Gln Ile Thr Arg
                      100 105
           <![CDATA[ <210> 352]]>
           <![CDATA[ <211> 107]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 352]]>
          Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
          1 5 10 15
          Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr
                      20 25 30
          Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
                  35 40 45
          Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
              50 55 60
          Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro
          65 70 75 80
          Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp
                          85 90 95
          Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
                      100 105
           <![CDATA[ <210> 353]]>
           <![CDATA[ <211> 107]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 353]]>
          Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
          1 5 10 15
          Asp Arg Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met
                      20 25 30
          His Trp Tyr Gln Gln Thr Pro Gly Lys Ala Pro Lys Pro Trp Ile Tyr
                  35 40 45
          Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
              50 55 60
          Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu
          65 70 75 80
          Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr
                          85 90 95
          Phe Gly Gln Gly Thr Lys Leu Gln Ile Thr Arg
                      100 105
           <![CDATA[ <210> 354]]>
           <![CDATA[ <211> 107]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 354]]>
          Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
          1 5 10 15
          Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      20 25 30
          Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr
                  35 40 45
          Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser
              50 55 60
          Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly Met Glu Ala Glu
          65 70 75 80
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr
                          85 90 95
          Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn Arg
                      100 105
           <![CDATA[ <210> 355]]>
           <![CDATA[ <211> 106]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 355]]>
          Asp Ile Gln Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
          1 5 10 15
          Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met
                      20 25 30
          Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr
                  35 40 45
          Asp Thr Ser Lys Val Ala Ser Gly Val Pro Tyr Arg Phe Ser Gly Ser
              50 55 60
          Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu
          65 70 75 80
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr
                          85 90 95
          Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
                      100 105
           <![CDATA[ <210> 356]]>
           <![CDATA[ <211> 106]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 356]]>
          Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
          1 5 10 15
          Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Tyr Met
                      20 25 30
          Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr
                  35 40 45
          Asp Thr Ser Lys Val Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
              50 55 60
          Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Asn Ser Leu Glu Ala Glu
          65 70 75 80
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr
                          85 90 95
          Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
                      100 105
           <![CDATA[ <210> 357]]>
           <![CDATA[ <211> 109]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 357]]>
          Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly
          1 5 10 15
          Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly
                      20 25 30
          Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly
                  35 40 45
          Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe
              50 55 60
          Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val
          65 70 75 80
          Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn
                          85 90 95
          Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
                      100 105
           <![CDATA[ <210> 358]]>
           <![CDATA[ <211> 109]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 358]]>
          Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly
          1 5 10 15
          Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser
                      20 25 30
          Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly
                  35 40 45
          Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Val Pro Ala Arg Phe
              50 55 60
          Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala
          65 70 75 80
          Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn
                          85 90 95
          Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
                      100 105
           <![CDATA[ <210> 359]]>
           <![CDATA[ <211> 109]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 359]]>
          Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly
          1 5 10 15
          Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser
                      20 25 30
          Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly
                  35 40 45
          Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe
              50 55 60
          Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val
          65 70 75 80
          Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn
                          85 90 95
          Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
                      100 105
           <![CDATA[ <210> 360]]>
           <![CDATA[ <211> 109]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 360]]>
          Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu
          1 5 10 15
          Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser
                      20 25 30
          Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly
                  35 40 45
          Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Val Pro Ala Arg Phe
              50 55 60
          Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala
          65 70 75 80
          Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn
                          85 90 95
          Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
                      100 105
           <![CDATA[ <210> 361]]>
           <![CDATA[ <400> 361]]>
          000
           <![CDATA[ <210> 362]]>
           <![CDATA[ <400> 362]]>
          000
           <![CDATA[ <210> 363]]>
           <![CDATA[ <400> 363]]>
          000
           <![CDATA[ <210> 364]]>
           <![CDATA[ <400> 364]]>
          000
           <![CDATA[ <210> 365]]>
           <![CDATA[ <400> 365]]>
          000
           <![CDATA[ <210> 366]]>
           <![CDATA[ <400> 366]]>
          000
           <![CDATA[ <210> 367]]>
           <![CDATA[ <400> 367]]>
          000
           <![CDATA[ <210> 368]]>
           <![CDATA[ <400> 368]]>
          000
           <![CDATA[ <210> 369]]>
           <![CDATA[ <400> 369]]>
          000
           <![CDATA[ <210> 370]]>
           <![CDATA[ <400> 370]]>
          000
           <![CDATA[ <210> 371]]>
           <![CDATA[ <400> 371]]>
          000
           <![CDATA[ <210> 372]]>
           <![CDATA[ <400> 372]]>
          000
           <![CDATA[ <210> 373]]>
           <![CDATA[ <400> 373]]>
          000
           <![CDATA[ <210> 374]]>
           <![CDATA[ <400> 374]]>
          000
           <![CDATA[ <210> 375]]>
           <![CDATA[ <400> 375]]>
          000
           <![CDATA[ <210> 376]]>
           <![CDATA[ <400> 376]]>
          000
           <![CDATA[ <210> 377]]>
           <![CDATA[ <400> 377]]>
          000
           <![CDATA[ <210> 378]]>
           <![CDATA[ <400> 378]]>
          000
           <![CDATA[ <210> 379]]>
           <![CDATA[ <400> 379]]>
          000
           <![CDATA[ <210> 380]]>
           <![CDATA[ <400> 380]]>
          000
           <![CDATA[ <210> 381]]>
           <![CDATA[ <400> 381]]>
          000
           <![CDATA[ <210> 382]]>
           <![CDATA[ <400> 382]]>
          000
           <![CDATA[ <210> 383]]>
           <![CDATA[ <400> 383]]>
          000
           <![CDATA[ <210> 384]]>
           <![CDATA[ <400> 384]]>
          000
           <![CDATA[ <210> 385]]>
           <![CDATA[ <400> 385]]>
          000
           <![CDATA[ <210> 386]]>
           <![CDATA[ <400> 386]]>
          000
           <![CDATA[ <210> 387]]>
           <![CDATA[ <400> 387]]>
          000
           <![CDATA[ <210> 388]]>
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           <![CDATA[ <210> 578]]>
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           <![CDATA[ <210> 579]]>
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          000
           <![CDATA[ <210> 588]]>
           <![CDATA[ <400> 588]]>
          000
           <![CDATA[ <210> 589]]>
           <![CDATA[ <400> 589]]>
          000
           <![CDATA[ <210> 590]]>
           <![CDATA[ <400> 590]]>
          000
           <![CDATA[ <210> 591]]>
           <![CDATA[ <400> 591]]>
          000
           <![CDATA[ <210> 592]]>
           <![CDATA[ <400> 592]]>
          000
           <![CDATA[ <210> 593]]>
           <![CDATA[ <400> 593]]>
          000
           <![CDATA[ <210> 594]]>
           <![CDATA[ <400> 594]]>
          000
           <![CDATA[ <210> 595]]>
           <![CDATA[ <400> 595]]>
          000
           <![CDATA[ <210> 596]]>
           <![CDATA[ <400> 596]]>
          000
           <![CDATA[ <210> 597]]>
           <![CDATA[ <400> 597]]>
          000
           <![CDATA[ <210> 598]]>
           <![CDATA[ <400> 598]]>
          000
           <![CDATA[ <210> 599]]>
           <![CDATA[ <400> 599]]>
          000
           <![CDATA[ <210> 600]]>
           <![CDATA[ <400> 600]]>
          000
           <![CDATA[ <210> 601]]>
           <![CDATA[ <211> 144]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 601]]>
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu
          1 5 10 15
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly
                      20 25 30
          Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
                  35 40 45
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro
              50 55 60
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly
          65 70 75 80
          Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro
                          85 90 95
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu
                      100 105 110
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly
                  115 120 125
          Ser Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
              130 135 140
           <![CDATA[ <210> 602]]>
           <![CDATA[ <211> 144]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 602]]>
          Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser
          1 5 10 15
          Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly
                      20 25 30
          Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly
                  35 40 45
          Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu
              50 55 60
          Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu
          65 70 75 80
          Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                          85 90 95
          Ser Glu Pro Ala Thr Ser Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly
                      100 105 110
          Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu
                  115 120 125
          Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
              130 135 140
           <![CDATA[ <210> 603]]>
           <![CDATA[ <211> 144]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 603]]>
          Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly
          1 5 10 15
          Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Thr Glu Gly
                      20 25 30
          Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
                  35 40 45
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu
              50 55 60
          Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu
          65 70 75 80
          Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                          85 90 95
          Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu
                      100 105 110
          Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu
                  115 120 125
          Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly
              130 135 140
           <![CDATA[ <210> 604]]>
           <![CDATA[ <211> 144]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 604]]>
          Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly
          1 5 10 15
          Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Thr Glu Gly
                      20 25 30
          Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
                  35 40 45
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu
              50 55 60
          Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu
          65 70 75 80
          Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                          85 90 95
          Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu
                      100 105 110
          Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu
                  115 120 125
          Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly
              130 135 140
           <![CDATA[ <210> 605]]>
           <![CDATA[ <211> 144]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 605]]>
          Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser
          1 5 10 15
          Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser
                      20 25 30
          Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly
                  35 40 45
          Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu
              50 55 60
          Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly
          65 70 75 80
          Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
                          85 90 95
          Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu
                      100 105 110
          Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser
                  115 120 125
          Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
              130 135 140
           <![CDATA[ <210> 606]]>
           <![CDATA[ <211> 144]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 606]]>
          Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser
          1 5 10 15
          Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser
                      20 25 30
          Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly
                  35 40 45
          Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu
              50 55 60
          Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly
          65 70 75 80
          Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
                          85 90 95
          Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu
                      100 105 110
          Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser
                  115 120 125
          Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
              130 135 140
           <![CDATA[ <210> 607]]>
           <![CDATA[ <211> 144]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 607]]>
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala
          1 5 10 15
          Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu
                      20 25 30
          Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                  35 40 45
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu
              50 55 60
          Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu
          65 70 75 80
          Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly
                          85 90 95
          Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly
                      100 105 110
          Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu
                  115 120 125
          Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
              130 135 140
           <![CDATA[ <210> 608]]>
           <![CDATA[ <211> 144]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 608]]>
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala
          1 5 10 15
          Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu
                      20 25 30
          Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                  35 40 45
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu
              50 55 60
          Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu
          65 70 75 80
          Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly
                          85 90 95
          Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly
                      100 105 110
          Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu
                  115 120 125
          Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
              130 135 140
           <![CDATA[ <210> 609]]>
           <![CDATA[ <211> 144]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 609]]>
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala
          1 5 10 15
          Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu
                      20 25 30
          Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                  35 40 45
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu
              50 55 60
          Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser
          65 70 75 80
          Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly
                          85 90 95
          Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser
                      100 105 110
          Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser
                  115 120 125
          Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly
              130 135 140
           <![CDATA[ <210> 610]]>
           <![CDATA[ <211> 144]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 610]]>
          Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser
          1 5 10 15
          Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu
                      20 25 30
          Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly
                  35 40 45
          Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala
              50 55 60
          Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser
          65 70 75 80
          Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
                          85 90 95
          Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro Ala
                      100 105 110
          Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu
                  115 120 125
          Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
              130 135 140
           <![CDATA[ <210> 611]]>
           <![CDATA[ <211> 288]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 611]]>
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro
          1 5 10 15
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro
                      20 25 30
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro
                  35 40 45
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Ser Thr
              50 55 60
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr
          65 70 75 80
          Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                          85 90 95
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu
                      100 105 110
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr
                  115 120 125
          Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
              130 135 140
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu
          145 150 155 160
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Ser Glu Ser Ala Thr Pro
                          165 170 175
          Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                      180 185 190
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro
                  195 200 205
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr
              210 215 220
          Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala Pro
          225 230 235 240
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro
                          245 250 255
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro
                      260 265 270
          Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
                  275 280 285
           <![CDATA[ <210> 612]]>
           <![CDATA[ <211> 288]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 612]]>
          Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu
          1 5 10 15
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly
                      20 25 30
          Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                  35 40 45
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Ser Thr
              50 55 60
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu
          65 70 75 80
          Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
                          85 90 95
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Ser Thr
                      100 105 110
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr
                  115 120 125
          Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala Pro
              130 135 140
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro
          145 150 155 160
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro
                          165 170 175
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro
                      180 185 190
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Ser Thr
                  195 200 205
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro
              210 215 220
          Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
          225 230 235 240
          Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala
                          245 250 255
          Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro
                      260 265 270
          Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
                  275 280 285
           <![CDATA[ <210> 613]]>
           <![CDATA[ <211> 576]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 613]]>
          Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu
          1 5 10 15
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu
                      20 25 30
          Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
                  35 40 45
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Ser Thr
              50 55 60
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro
          65 70 75 80
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro
                          85 90 95
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala
                      100 105 110
          Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro
                  115 120 125
          Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
              130 135 140
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala
          145 150 155 160
          Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu
                          165 170 175
          Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
                      180 185 190
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Ser Thr
                  195 200 205
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro
              210 215 220
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro
          225 230 235 240
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Ser Thr
                          245 250 255
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro
                      260 265 270
          Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                  275 280 285
          Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu
              290 295 300
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly
          305 310 315 320
          Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                          325 330 335
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Ser Thr
                      340 345 350
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu
                  355 360 365
          Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
              370 375 380
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Ser Thr
          385 390 395 400
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr
                          405 410 415
          Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala Pro
                      420 425 430
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro
                  435 440 445
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro
              450 455 460
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro
          465 470 475 480
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Ser Thr
                          485 490 495
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro
                      500 505 510
          Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
                  515 520 525
          Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala
              530 535 540
          Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro
          545 550 555 560
          Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
                          565 570 575
           <![CDATA[ <210> 614]]>
           <![CDATA[ <211> 625]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 614]]>
          Met Ala Glu Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Pro
          1 5 10 15
          Gly Ser Gly Thr Ala Ser Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly
                      20 25 30
          Ala Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser
                  35 40 45
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
              50 55 60
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
          65 70 75 80
          Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
                          85 90 95
          Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                      100 105 110
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
                  115 120 125
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
              130 135 140
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro
          145 150 155 160
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
                          165 170 175
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                      180 185 190
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro
                  195 200 205
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser
              210 215 220
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
          225 230 235 240
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                          245 250 255
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
                      260 265 270
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
                  275 280 285
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
              290 295 300
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
          305 310 315 320
          Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                          325 330 335
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
                      340 345 350
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
                  355 360 365
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
              370 375 380
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
          385 390 395 400
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser
                          405 410 415
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                      420 425 430
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                  435 440 445
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro
              450 455 460
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
          465 470 475 480
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu
                          485 490 495
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr
                      500 505 510
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
                  515 520 525
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
              530 535 540
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
          545 550 555 560
          Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
                          565 570 575
          Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro
                      580 585 590
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
                  595 600 605
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
              610 615 620
          Pro
          625
           <![CDATA[ <210> 615]]>
           <![CDATA[ <211> 864]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 615]]>
          Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu
          1 5 10 15
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu
                      20 25 30
          Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
                  35 40 45
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Ser Thr
              50 55 60
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro
          65 70 75 80
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro
                          85 90 95
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala
                      100 105 110
          Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro
                  115 120 125
          Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
              130 135 140
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala
          145 150 155 160
          Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu
                          165 170 175
          Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
                      180 185 190
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Ser Thr
                  195 200 205
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro
              210 215 220
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro
          225 230 235 240
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Ser Thr
                          245 250 255
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro
                      260 265 270
          Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                  275 280 285
          Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu
              290 295 300
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly
          305 310 315 320
          Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                          325 330 335
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Ser Thr
                      340 345 350
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu
                  355 360 365
          Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
              370 375 380
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Ser Thr
          385 390 395 400
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr
                          405 410 415
          Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala Pro
                      420 425 430
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro
                  435 440 445
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro
              450 455 460
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro
          465 470 475 480
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Ser Thr
                          485 490 495
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro
                      500 505 510
          Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
                  515 520 525
          Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala
              530 535 540
          Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro
          545 550 555 560
          Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
                          565 570 575
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro
                      580 585 590
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro
                  595 600 605
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro
              610 615 620
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Ser Thr
          625 630 635 640
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr
                          645 650 655
          Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                      660 665 670
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu
                  675 680 685
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr
              690 695 700
          Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
          705 710 715 720
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu
                          725 730 735
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Ser Glu Ser Ala Thr Pro
                      740 745 750
          Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                  755 760 765
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro
              770 775 780
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr
          785 790 795 800
          Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala Pro
                          805 810 815
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro
                      820 825 830
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro
                  835 840 845
          Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
              850 855 860
           <![CDATA[ <210> 616]]>
           <![CDATA[ <211> 865]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 616]]>
          Gly Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
          1 5 10 15
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
                      20 25 30
          Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
                  35 40 45
          Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
              50 55 60
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
          65 70 75 80
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
                          85 90 95
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro
                      100 105 110
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
                  115 120 125
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
              130 135 140
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro
          145 150 155 160
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser
                          165 170 175
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                      180 185 190
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                  195 200 205
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
              210 215 220
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
          225 230 235 240
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                          245 250 255
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
                      260 265 270
          Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  275 280 285
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
              290 295 300
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
          305 310 315 320
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                          325 330 335
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                      340 345 350
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser
                  355 360 365
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
              370 375 380
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
          385 390 395 400
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro
                          405 410 415
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
                      420 425 430
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu
                  435 440 445
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr
              450 455 460
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
          465 470 475 480
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                          485 490 495
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
                      500 505 510
          Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
                  515 520 525
          Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro
              530 535 540
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
          545 550 555 560
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                          565 570 575
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu
                      580 585 590
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr
                  595 600 605
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
              610 615 620
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
          625 630 635 640
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro
                          645 650 655
          Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                      660 665 670
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
                  675 680 685
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro
              690 695 700
          Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
          705 710 715 720
          Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                          725 730 735
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr
                      740 745 750
          Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  755 760 765
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu
              770 775 780
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro
          785 790 795 800
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
                          805 810 815
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu
                      820 825 830
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr
                  835 840 845
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
              850 855 860
          Pro
          865
           <![CDATA[ <210> 617]]>
           <![CDATA[ <211> 866]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 617]]>
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
          1 5 10 15
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
                      20 25 30
          Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
                  35 40 45
          Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
              50 55 60
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
          65 70 75 80
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
                          85 90 95
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro
                      100 105 110
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
                  115 120 125
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
              130 135 140
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro
          145 150 155 160
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser
                          165 170 175
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                      180 185 190
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                  195 200 205
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
              210 215 220
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
          225 230 235 240
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                          245 250 255
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
                      260 265 270
          Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  275 280 285
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
              290 295 300
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
          305 310 315 320
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                          325 330 335
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                      340 345 350
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser
                  355 360 365
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
              370 375 380
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
          385 390 395 400
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro
                          405 410 415
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
                      420 425 430
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu
                  435 440 445
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr
              450 455 460
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
          465 470 475 480
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                          485 490 495
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
                      500 505 510
          Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
                  515 520 525
          Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro
              530 535 540
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
          545 550 555 560
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                          565 570 575
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu
                      580 585 590
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr
                  595 600 605
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
              610 615 620
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
          625 630 635 640
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro
                          645 650 655
          Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                      660 665 670
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
                  675 680 685
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro
              690 695 700
          Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
          705 710 715 720
          Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                          725 730 735
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr
                      740 745 750
          Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  755 760 765
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu
              770 775 780
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro
          785 790 795 800
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
                          805 810 815
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu
                      820 825 830
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr
                  835 840 845
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
              850 855 860
          Pro Gly
          865
           <![CDATA[ <210> 618]]>
           <![CDATA[ <211> 1152]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 618]]>
          Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu
          1 5 10 15
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu
                      20 25 30
          Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
                  35 40 45
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Ser Thr
              50 55 60
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro
          65 70 75 80
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro
                          85 90 95
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala
                      100 105 110
          Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro
                  115 120 125
          Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
              130 135 140
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala
          145 150 155 160
          Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu
                          165 170 175
          Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
                      180 185 190
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Ser Thr
                  195 200 205
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro
              210 215 220
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro
          225 230 235 240
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Ser Thr
                          245 250 255
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro
                      260 265 270
          Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                  275 280 285
          Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu
              290 295 300
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly
          305 310 315 320
          Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                          325 330 335
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Ser Thr
                      340 345 350
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu
                  355 360 365
          Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
              370 375 380
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Ser Thr
          385 390 395 400
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr
                          405 410 415
          Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala Pro
                      420 425 430
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro
                  435 440 445
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro
              450 455 460
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro
          465 470 475 480
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Ser Thr
                          485 490 495
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro
                      500 505 510
          Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
                  515 520 525
          Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala
              530 535 540
          Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro
          545 550 555 560
          Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
                          565 570 575
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro
                      580 585 590
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro
                  595 600 605
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro
              610 615 620
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Ser Thr
          625 630 635 640
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr
                          645 650 655
          Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                      660 665 670
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu
                  675 680 685
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr
              690 695 700
          Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
          705 710 715 720
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu
                          725 730 735
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Ser Glu Ser Ala Thr Pro
                      740 745 750
          Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                  755 760 765
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro
              770 775 780
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr
          785 790 795 800
          Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala Pro
                          805 810 815
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro
                      820 825 830
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro
                  835 840 845
          Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
              850 855 860
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro
          865 870 875 880
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro
                          885 890 895
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro
                      900 905 910
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Ser Thr
                  915 920 925
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr
              930 935 940
          Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
          945 950 955 960
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu
                          965 970 975
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr
                      980 985 990
          Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
                  995 1000 1005
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
              1010 1015 1020
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala
              1025 1030 1035
          Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu
              1040 1045 1050
          Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro
              1055 1060 1065
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro
              1070 1075 1080
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro
              1085 1090 1095
          Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly
              1100 1105 1110
          Ser Ala Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro
              1115 1120 1125
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
              1130 1135 1140
          Thr Glu Pro Ser Glu Gly Ser Ala Pro
              1145 1150
           <![CDATA[ <210> 619]]>
           <![CDATA[ <211> 144]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 619]]>
          Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser
          1 5 10 15
          Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser
                      20 25 30
          Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser
                  35 40 45
          Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala
              50 55 60
          Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu
          65 70 75 80
          Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr
                          85 90 95
          Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala
                      100 105 110
          Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr
                  115 120 125
          Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser
              130 135 140
           <![CDATA[ <210> 620]]>
           <![CDATA[ <211> 144]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 620]]>
          Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser
          1 5 10 15
          Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser
                      20 25 30
          Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly
                  35 40 45
          Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly
              50 55 60
          Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu
          65 70 75 80
          Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                          85 90 95
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly
                      100 105 110
          Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser
                  115 120 125
          Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
              130 135 140
           <![CDATA[ <210> 621]]>
           <![CDATA[ <211> 180]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 621]]>
          Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
          1 5 10 15
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
                      20 25 30
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro
                  35 40 45
          Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
              50 55 60
          Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
          65 70 75 80
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr
                          85 90 95
          Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                      100 105 110
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu
                  115 120 125
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro
              130 135 140
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
          145 150 155 160
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu
                          165 170 175
          Pro Ala Thr Ser
                      180
           <![CDATA[ <210> 622]]>
           <![CDATA[ <211> 216]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 622]]>
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
          1 5 10 15
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
                      20 25 30
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
                  35 40 45
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
              50 55 60
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro
          65 70 75 80
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser
                          85 90 95
          Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                      100 105 110
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                  115 120 125
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
              130 135 140
          Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
          145 150 155 160
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
                          165 170 175
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser
                      180 185 190
          Glu Gly Ser Ala Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
                  195 200 205
          Pro Gly Thr Ser Glu Ser Ala Thr
              210 215
           <![CDATA[ <210> 623]]>
           <![CDATA[ <211> 252]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 623]]>
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro
          1 5 10 15
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Ser Thr
                      20 25 30
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr
                  35 40 45
          Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
              50 55 60
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu
          65 70 75 80
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr
                          85 90 95
          Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
                      100 105 110
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu
                  115 120 125
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Ser Glu Ser Ala Thr Pro
              130 135 140
          Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
          145 150 155 160
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro
                          165 170 175
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr
                      180 185 190
          Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala Pro
                  195 200 205
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro
              210 215 220
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro
          225 230 235 240
          Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu
                          245 250
           <![CDATA[ <210> 624]]>
           <![CDATA[ <211> 288]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 624]]>
          Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser
          1 5 10 15
          Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser
                      20 25 30
          Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala
                  35 40 45
          Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu
              50 55 60
          Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr
          65 70 75 80
          Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser
                          85 90 95
          Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser
                      100 105 110
          Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                  115 120 125
          Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser
              130 135 140
          Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr
          145 150 155 160
          Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr
                          165 170 175
          Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala
                      180 185 190
          Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser
                  195 200 205
          Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser
              210 215 220
          Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser
          225 230 235 240
          Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser
                          245 250 255
          Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser
                      260 265 270
          Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala
                  275 280 285
           <![CDATA[ <210> 625]]>
           <![CDATA[ <211> 324]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 625]]>
          Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
          1 5 10 15
          Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro
                      20 25 30
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
                  35 40 45
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
              50 55 60
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu
          65 70 75 80
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr
                          85 90 95
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
                      100 105 110
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                  115 120 125
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro
              130 135 140
          Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
          145 150 155 160
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
                          165 170 175
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro
                      180 185 190
          Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
                  195 200 205
          Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
              210 215 220
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr
          225 230 235 240
          Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                          245 250 255
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu
                      260 265 270
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro
                  275 280 285
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
              290 295 300
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu
          305 310 315 320
          Pro Ala Thr Ser
           <![CDATA[ <210> 626]]>
           <![CDATA[ <211> 360]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 626]]>
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
          1 5 10 15
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro
                      20 25 30
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro
                  35 40 45
          Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
              50 55 60
          Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
          65 70 75 80
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
                          85 90 95
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
                      100 105 110
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu
                  115 120 125
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr
              130 135 140
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
          145 150 155 160
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
                          165 170 175
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
                      180 185 190
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  195 200 205
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro
              210 215 220
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser
          225 230 235 240
          Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                          245 250 255
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                      260 265 270
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
                  275 280 285
          Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
              290 295 300
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
          305 310 315 320
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser
                          325 330 335
          Glu Gly Ser Ala Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
                      340 345 350
          Pro Gly Thr Ser Glu Ser Ala Thr
                  355 360
           <![CDATA[ <210> 627]]>
           <![CDATA[ <211> 360]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 627]]>
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
          1 5 10 15
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                      20 25 30
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
                  35 40 45
          Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
              50 55 60
          Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro
          65 70 75 80
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
                          85 90 95
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                      100 105 110
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu
                  115 120 125
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr
              130 135 140
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
          145 150 155 160
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                          165 170 175
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro
                      180 185 190
          Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  195 200 205
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
              210 215 220
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro
          225 230 235 240
          Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
                          245 250 255
          Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                      260 265 270
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr
                  275 280 285
          Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
              290 295 300
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu
          305 310 315 320
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro
                          325 330 335
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
                      340 345 350
          Pro Gly Thr Ser Thr Glu Pro Ser
                  355 360
           <![CDATA[ <210> 628]]>
           <![CDATA[ <211> 432]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 628]]>
          Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
          1 5 10 15
          Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                      20 25 30
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
                  35 40 45
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
              50 55 60
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
          65 70 75 80
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
                          85 90 95
          Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                      100 105 110
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro
                  115 120 125
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro
              130 135 140
          Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
          145 150 155 160
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                          165 170 175
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
                      180 185 190
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  195 200 205
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
              210 215 220
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
          225 230 235 240
          Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
                          245 250 255
          Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu
                      260 265 270
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr
                  275 280 285
          Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
              290 295 300
          Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
          305 310 315 320
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
                          325 330 335
          Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                      340 345 350
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu
                  355 360 365
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser
              370 375 380
          Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
          385 390 395 400
          Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                          405 410 415
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro Ala Thr Ser
                      420 425 430
           <![CDATA[ <210> 629]]>
           <![CDATA[ <211> 468]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 629]]>
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
          1 5 10 15
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro
                      20 25 30
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser
                  35 40 45
          Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
              50 55 60
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
          65 70 75 80
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
                          85 90 95
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                      100 105 110
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                  115 120 125
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro
              130 135 140
          Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
          145 150 155 160
          Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
                          165 170 175
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
                      180 185 190
          Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  195 200 205
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
              210 215 220
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
          225 230 235 240
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                          245 250 255
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro
                      260 265 270
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
                  275 280 285
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
              290 295 300
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro
          305 310 315 320
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro
                          325 330 335
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
                      340 345 350
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                  355 360 365
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr
              370 375 380
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
          385 390 395 400
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro
                          405 410 415
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser
                      420 425 430
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                  435 440 445
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
              450 455 460
          Glu Ser Ala Thr
          465
           <![CDATA[ <210> 630]]>
           <![CDATA[ <211> 504]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 630]]>
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
          1 5 10 15
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                      20 25 30
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser
                  35 40 45
          Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
              50 55 60
          Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
          65 70 75 80
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
                          85 90 95
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                      100 105 110
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
                  115 120 125
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
              130 135 140
          Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
          145 150 155 160
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro
                          165 170 175
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro
                      180 185 190
          Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  195 200 205
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
              210 215 220
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
          225 230 235 240
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                          245 250 255
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
                      260 265 270
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
                  275 280 285
          Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
              290 295 300
          Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu
          305 310 315 320
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr
                          325 330 335
          Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
                      340 345 350
          Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
                  355 360 365
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
              370 375 380
          Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
          385 390 395 400
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu
                          405 410 415
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser
                      420 425 430
          Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
                  435 440 445
          Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
              450 455 460
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro Ala Thr Ser
          465 470 475 480
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                          485 490 495
          Pro Gly Thr Ser Thr Glu Pro Ser
                      500
           <![CDATA[ <210> 631]]>
           <![CDATA[ <211> 540]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 631]]>
          Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr
          1 5 10 15
          Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser
                      20 25 30
          Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala
                  35 40 45
          Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser
              50 55 60
          Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr
          65 70 75 80
          Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro
                          85 90 95
          Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser
                      100 105 110
          Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser
                  115 120 125
          Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro
              130 135 140
          Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser
          145 150 155 160
          Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                          165 170 175
          Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr
                      180 185 190
          Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser
                  195 200 205
          Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr
              210 215 220
          Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser
          225 230 235 240
          Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr
                          245 250 255
          Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr
                      260 265 270
          Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro
                  275 280 285
          Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser
              290 295 300
          Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
          305 310 315 320
          Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr
                          325 330 335
          Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser
                      340 345 350
          Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser
                  355 360 365
          Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala
              370 375 380
          Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu
          385 390 395 400
          Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser
                          405 410 415
          Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser
                      420 425 430
          Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser
                  435 440 445
          Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr
              450 455 460
          Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala
          465 470 475 480
          Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu
                          485 490 495
          Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser
                      500 505 510
          Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro
                  515 520 525
          Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro
              530 535 540
           <![CDATA[ <210> 632]]>
           <![CDATA[ <211> 576]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 632]]>
          Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser
          1 5 10 15
          Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr
                      20 25 30
          Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr
                  35 40 45
          Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser
              50 55 60
          Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr
          65 70 75 80
          Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro
                          85 90 95
          Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser
                      100 105 110
          Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr
                  115 120 125
          Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser
              130 135 140
          Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser
          145 150 155 160
          Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser
                          165 170 175
          Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala
                      180 185 190
          Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu
                  195 200 205
          Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr
              210 215 220
          Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala
          225 230 235 240
          Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr
                          245 250 255
          Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser
                      260 265 270
          Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala
                  275 280 285
          Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser
              290 295 300
          Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser
          305 310 315 320
          Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala
                          325 330 335
          Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu
                      340 345 350
          Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr
                  355 360 365
          Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser
              370 375 380
          Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser
          385 390 395 400
          Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                          405 410 415
          Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser
                      420 425 430
          Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr
                  435 440 445
          Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr
              450 455 460
          Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala
          465 470 475 480
          Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser
                          485 490 495
          Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser
                      500 505 510
          Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser
                  515 520 525
          Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser
              530 535 540
          Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser
          545 550 555 560
          Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala
                          565 570 575
           <![CDATA[ <210> 633]]>
           <![CDATA[ <211> 612]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 633]]>
          Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
          1 5 10 15
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                      20 25 30
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr
                  35 40 45
          Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
              50 55 60
          Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu
          65 70 75 80
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr
                          85 90 95
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                      100 105 110
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                  115 120 125
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser
              130 135 140
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
          145 150 155 160
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro
                          165 170 175
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser
                      180 185 190
          Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  195 200 205
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
              210 215 220
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
          225 230 235 240
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                          245 250 255
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                      260 265 270
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro
                  275 280 285
          Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
              290 295 300
          Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
          305 310 315 320
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
                          325 330 335
          Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                      340 345 350
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
                  355 360 365
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
              370 375 380
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
          385 390 395 400
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro
                          405 410 415
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
                      420 425 430
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
                  435 440 445
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro
              450 455 460
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro
          465 470 475 480
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
                          485 490 495
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                      500 505 510
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr
                  515 520 525
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
              530 535 540
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro
          545 550 555 560
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser
                          565 570 575
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                      580 585 590
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
                  595 600 605
          Glu Ser Ala Thr
              610
           <![CDATA[ <210> 634]]>
           <![CDATA[ <211> 648]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 634]]>
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
          1 5 10 15
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu
                      20 25 30
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser
                  35 40 45
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
              50 55 60
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
          65 70 75 80
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro
                          85 90 95
          Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                      100 105 110
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
                  115 120 125
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
              130 135 140
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
          145 150 155 160
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                          165 170 175
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser
                      180 185 190
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                  195 200 205
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
              210 215 220
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
          225 230 235 240
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
                          245 250 255
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu
                      260 265 270
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr
                  275 280 285
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
              290 295 300
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro
          305 310 315 320
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro
                          325 330 335
          Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
                      340 345 350
          Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                  355 360 365
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
              370 375 380
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
          385 390 395 400
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu
                          405 410 415
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr
                      420 425 430
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                  435 440 445
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
              450 455 460
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
          465 470 475 480
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                          485 490 495
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro
                      500 505 510
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser
                  515 520 525
          Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
              530 535 540
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
          545 550 555 560
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
                          565 570 575
          Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
                      580 585 590
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
                  595 600 605
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser
              610 615 620
          Glu Gly Ser Ala Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
          625 630 635 640
          Pro Gly Thr Ser Glu Ser Ala Thr
                          645
           <![CDATA[ <210> 635]]>
           <![CDATA[ <211> 684]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 635]]>
          Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
          1 5 10 15
          Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                      20 25 30
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
                  35 40 45
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
              50 55 60
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu
          65 70 75 80
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser
                          85 90 95
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                      100 105 110
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                  115 120 125
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro
              130 135 140
          Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
          145 150 155 160
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
                          165 170 175
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
                      180 185 190
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                  195 200 205
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
              210 215 220
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser
          225 230 235 240
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                          245 250 255
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
                      260 265 270
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
                  275 280 285
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
              290 295 300
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu
          305 310 315 320
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr
                          325 330 335
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                      340 345 350
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro
                  355 360 365
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro
              370 375 380
          Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
          385 390 395 400
          Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                          405 410 415
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
                      420 425 430
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
                  435 440 445
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu
              450 455 460
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr
          465 470 475 480
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                          485 490 495
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
                      500 505 510
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
                  515 520 525
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
              530 535 540
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro
          545 550 555 560
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser
                          565 570 575
          Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                      580 585 590
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                  595 600 605
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
              610 615 620
          Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
          625 630 635 640
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
                          645 650 655
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser
                      660 665 670
          Glu Gly Ser Ala Pro Gly Ser Glu Pro Ala Thr Ser
                  675 680
           <![CDATA[ <210> 636]]>
           <![CDATA[ <211> 720]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 636]]>
          Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser
          1 5 10 15
          Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly
                      20 25 30
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu
                  35 40 45
          Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly
              50 55 60
          Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly
          65 70 75 80
          Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu
                          85 90 95
          Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu
                      100 105 110
          Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
                  115 120 125
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala
              130 135 140
          Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly
          145 150 155 160
          Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
                          165 170 175
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser
                      180 185 190
          Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser
                  195 200 205
          Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly
              210 215 220
          Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser
          225 230 235 240
          Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly
                          245 250 255
          Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
                      260 265 270
          Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu
                  275 280 285
          Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly
              290 295 300
          Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
          305 310 315 320
          Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu
                          325 330 335
          Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu
                      340 345 350
          Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                  355 360 365
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala
              370 375 380
          Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu
          385 390 395 400
          Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
                          405 410 415
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly
                      420 425 430
          Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser
                  435 440 445
          Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly
              450 455 460
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu
          465 470 475 480
          Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu
                          485 490 495
          Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      500 505 510
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala
                  515 520 525
          Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu
              530 535 540
          Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
          545 550 555 560
          Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser
                          565 570 575
          Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser
                      580 585 590
          Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly
                  595 600 605
          Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly
              610 615 620
          Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Thr Glu Gly
          625 630 635 640
          Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly
                          645 650 655
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser
                      660 665 670
          Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser
                  675 680 685
          Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
              690 695 700
          Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu
          705 710 715 720
           <![CDATA[ <210> 637]]>
           <![CDATA[ <211> 756]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 637]]>
          Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser
          1 5 10 15
          Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly
                      20 25 30
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu
                  35 40 45
          Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly
              50 55 60
          Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly
          65 70 75 80
          Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu
                          85 90 95
          Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu
                      100 105 110
          Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
                  115 120 125
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala
              130 135 140
          Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly
          145 150 155 160
          Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
                          165 170 175
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser
                      180 185 190
          Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser
                  195 200 205
          Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly
              210 215 220
          Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser
          225 230 235 240
          Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly
                          245 250 255
          Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
                      260 265 270
          Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu
                  275 280 285
          Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly
              290 295 300
          Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
          305 310 315 320
          Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu
                          325 330 335
          Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu
                      340 345 350
          Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                  355 360 365
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala
              370 375 380
          Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu
          385 390 395 400
          Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
                          405 410 415
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly
                      420 425 430
          Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser
                  435 440 445
          Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly
              450 455 460
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu
          465 470 475 480
          Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu
                          485 490 495
          Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      500 505 510
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala
                  515 520 525
          Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu
              530 535 540
          Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
          545 550 555 560
          Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser
                          565 570 575
          Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser
                      580 585 590
          Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly
                  595 600 605
          Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly
              610 615 620
          Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Thr Glu Gly
          625 630 635 640
          Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly
                          645 650 655
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser
                      660 665 670
          Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser
                  675 680 685
          Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
              690 695 700
          Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu
          705 710 715 720
          Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly
                          725 730 735
          Ser Ala Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      740 745 750
          Thr Ser Glu Ser
                  755
           <![CDATA[ <210> 638]]>
           <![CDATA[ <211> 792]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 638]]>
          Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
          1 5 10 15
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu
                      20 25 30
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro
                  35 40 45
          Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
              50 55 60
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
          65 70 75 80
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro
                          85 90 95
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
                      100 105 110
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                  115 120 125
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
              130 135 140
          Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
          145 150 155 160
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
                          165 170 175
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser
                      180 185 190
          Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  195 200 205
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro
              210 215 220
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
          225 230 235 240
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
                          245 250 255
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                      260 265 270
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser
                  275 280 285
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
              290 295 300
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
          305 310 315 320
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser
                          325 330 335
          Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
                      340 345 350
          Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                  355 360 365
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
              370 375 380
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
          385 390 395 400
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
                          405 410 415
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
                      420 425 430
          Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  435 440 445
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro
              450 455 460
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro
          465 470 475 480
          Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                          485 490 495
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                      500 505 510
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
                  515 520 525
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
              530 535 540
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
          545 550 555 560
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
                          565 570 575
          Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
                      580 585 590
          Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu
                  595 600 605
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr
              610 615 620
          Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
          625 630 635 640
          Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
                          645 650 655
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
                      660 665 670
          Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  675 680 685
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu
              690 695 700
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser
          705 710 715 720
          Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
                          725 730 735
          Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                      740 745 750
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro Ala Thr Ser
                  755 760 765
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
              770 775 780
          Pro Gly Thr Ser Thr Glu Pro Ser
          785 790
           <![CDATA[ <210> 639]]>
           <![CDATA[ <211> 828]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 639]]>
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
          1 5 10 15
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
                      20 25 30
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser
                  35 40 45
          Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
              50 55 60
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu
          65 70 75 80
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro
                          85 90 95
          Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                      100 105 110
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                  115 120 125
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro
              130 135 140
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
          145 150 155 160
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                          165 170 175
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
                      180 185 190
          Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  195 200 205
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
              210 215 220
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser
          225 230 235 240
          Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                          245 250 255
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro
                      260 265 270
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
                  275 280 285
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
              290 295 300
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
          305 310 315 320
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser
                          325 330 335
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                      340 345 350
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                  355 360 365
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser
              370 375 380
          Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
          385 390 395 400
          Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                          405 410 415
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
                      420 425 430
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  435 440 445
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
              450 455 460
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
          465 470 475 480
          Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                          485 490 495
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro
                      500 505 510
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro
                  515 520 525
          Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
              530 535 540
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
          545 550 555 560
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
                          565 570 575
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                      580 585 590
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
                  595 600 605
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
              610 615 620
          Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
          625 630 635 640
          Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu
                          645 650 655
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr
                      660 665 670
          Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
                  675 680 685
          Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
              690 695 700
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
          705 710 715 720
          Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                          725 730 735
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu
                      740 745 750
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser
                  755 760 765
          Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
              770 775 780
          Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
          785 790 795 800
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro Ala Thr Ser
                          805 810 815
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr
                      820 825
           <![CDATA[ <210> 640]]>
           <![CDATA[ <211> 869]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 640]]>
          Gly Ser Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly
          1 5 10 15
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu
                      20 25 30
          Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser
                  35 40 45
          Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
              50 55 60
          Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser
          65 70 75 80
          Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser
                          85 90 95
          Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      100 105 110
          Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser
                  115 120 125
          Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly
              130 135 140
          Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
          145 150 155 160
          Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu
                          165 170 175
          Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly
                      180 185 190
          Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly
                  195 200 205
          Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser
              210 215 220
          Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser
          225 230 235 240
          Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
                          245 250 255
          Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser
                      260 265 270
          Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu
                  275 280 285
          Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly
              290 295 300
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala
          305 310 315 320
          Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu
                          325 330 335
          Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
                      340 345 350
          Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu
                  355 360 365
          Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly
              370 375 380
          Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
          385 390 395 400
          Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly
                          405 410 415
          Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Thr Glu Gly
                      420 425 430
          Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly
                  435 440 445
          Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser
              450 455 460
          Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser
          465 470 475 480
          Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly
                          485 490 495
          Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser
                      500 505 510
          Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser
                  515 520 525
          Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly
              530 535 540
          Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser
          545 550 555 560
          Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly
                          565 570 575
          Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly
                      580 585 590
          Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser
                  595 600 605
          Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser
              610 615 620
          Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly
          625 630 635 640
          Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly
                          645 650 655
          Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu
                      660 665 670
          Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                  675 680 685
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly
              690 695 700
          Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser
          705 710 715 720
          Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
                          725 730 735
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser
                      740 745 750
          Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu
                  755 760 765
          Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
              770 775 780
          Ser Glu Pro Ala Thr Ser Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly
          785 790 795 800
          Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Thr Glu Gly
                          805 810 815
          Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
                      820 825 830
          Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser
                  835 840 845
          Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly
              850 855 860
          Ser Ala Pro Gly Arg
          865
           <![CDATA[ <210> 641]]>
           <![CDATA[ <211> 144]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 641]]>
          Ser Ala Gly Ser Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
          1 5 10 15
          Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                      20 25 30
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro
                  35 40 45
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
              50 55 60
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
          65 70 75 80
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
                          85 90 95
          Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
                      100 105 110
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
                  115 120 125
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Glu Ser Ala Ser Arg
              130 135 140
           <![CDATA[ <210> 642]]>
           <![CDATA[ <211> 288]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 642]]>
          Ser Ala Gly Ser Pro Thr Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly
          1 5 10 15
          Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                      20 25 30
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu
                  35 40 45
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu
              50 55 60
          Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
          65 70 75 80
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro
                          85 90 95
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro
                      100 105 110
          Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
                  115 120 125
          Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr
              130 135 140
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro
          145 150 155 160
          Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                          165 170 175
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro
                      180 185 190
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly
                  195 200 205
          Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
              210 215 220
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Ser Thr
          225 230 235 240
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro Ala Thr Ser Ser Gly
                          245 250 255
          Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                      260 265 270
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Ser Ala Ser Arg
                  275 280 285
           <![CDATA[ <210> 643]]>
           <![CDATA[ <211> 432]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 643]]>
          Ser Ala Gly Ser Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
          1 5 10 15
          Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                      20 25 30
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro
                  35 40 45
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
              50 55 60
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
          65 70 75 80
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
                          85 90 95
          Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
                      100 105 110
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
                  115 120 125
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
              130 135 140
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
          145 150 155 160
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
                          165 170 175
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser
                      180 185 190
          Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  195 200 205
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
              210 215 220
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
          225 230 235 240
          Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                          245 250 255
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                      260 265 270
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr
                  275 280 285
          Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
              290 295 300
          Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu
          305 310 315 320
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr
                          325 330 335
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                      340 345 350
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                  355 360 365
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser
              370 375 380
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
          385 390 395 400
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro
                          405 410 415
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Glu Ser Ala Ser Arg
                      420 425 430
           <![CDATA[ <210> 644]]>
           <![CDATA[ <211> 576]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 644]]>
          Ser Ala Gly Ser Pro Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro
          1 5 10 15
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro
                      20 25 30
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Ser Thr
                  35 40 45
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu
              50 55 60
          Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
          65 70 75 80
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Ser Thr
                          85 90 95
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu
                      100 105 110
          Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
                  115 120 125
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu
              130 135 140
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly
          145 150 155 160
          Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                          165 170 175
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu
                      180 185 190
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu
                  195 200 205
          Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
              210 215 220
          Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala
          225 230 235 240
          Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr
                          245 250 255
          Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                      260 265 270
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu
                  275 280 285
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly
              290 295 300
          Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
          305 310 315 320
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu
                          325 330 335
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu
                      340 345 350
          Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
                  355 360 365
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro
              370 375 380
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro
          385 390 395 400
          Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
                          405 410 415
          Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr
                      420 425 430
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro
                  435 440 445
          Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
              450 455 460
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro
          465 470 475 480
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly
                          485 490 495
          Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
                      500 505 510
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Ser Thr
                  515 520 525
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro Ala Thr Ser Ser Gly
              530 535 540
          Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
          545 550 555 560
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Ser Ala Ser Arg
                          565 570 575
           <![CDATA[ <210> 645]]>
           <![CDATA[ <211> 864]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 645]]>
          Ser Ala Gly Ser Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
          1 5 10 15
          Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                      20 25 30
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro
                  35 40 45
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
              50 55 60
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
          65 70 75 80
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
                          85 90 95
          Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
                      100 105 110
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
                  115 120 125
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
              130 135 140
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
          145 150 155 160
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
                          165 170 175
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser
                      180 185 190
          Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  195 200 205
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
              210 215 220
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
          225 230 235 240
          Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                          245 250 255
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                      260 265 270
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr
                  275 280 285
          Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
              290 295 300
          Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu
          305 310 315 320
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr
                          325 330 335
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                      340 345 350
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                  355 360 365
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser
              370 375 380
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
          385 390 395 400
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro
                          405 410 415
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser
                      420 425 430
          Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  435 440 445
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
              450 455 460
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
          465 470 475 480
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                          485 490 495
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                      500 505 510
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro
                  515 520 525
          Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
              530 535 540
          Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
          545 550 555 560
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
                          565 570 575
          Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                      580 585 590
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
                  595 600 605
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
              610 615 620
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
          625 630 635 640
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro
                          645 650 655
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
                      660 665 670
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
                  675 680 685
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro
              690 695 700
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro
          705 710 715 720
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
                          725 730 735
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                      740 745 750
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr
                  755 760 765
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
              770 775 780
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro
          785 790 795 800
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser
                          805 810 815
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                      820 825 830
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
                  835 840 845
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Glu Ser Ala Ser Arg
              850 855 860
           <![CDATA[ <210> 646]]>
           <![CDATA[ <211> 712]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 646]]>
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
          1 5 10 15
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
                      20 25 30
          Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
                  35 40 45
          Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
              50 55 60
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
          65 70 75 80
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
                          85 90 95
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro
                      100 105 110
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
                  115 120 125
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
              130 135 140
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro
          145 150 155 160
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser
                          165 170 175
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                      180 185 190
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                  195 200 205
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
              210 215 220
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
          225 230 235 240
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                          245 250 255
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
                      260 265 270
          Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  275 280 285
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
              290 295 300
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
          305 310 315 320
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                          325 330 335
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                      340 345 350
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser
                  355 360 365
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
              370 375 380
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
          385 390 395 400
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro
                          405 410 415
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
                      420 425 430
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu
                  435 440 445
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr
              450 455 460
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
          465 470 475 480
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                          485 490 495
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
                      500 505 510
          Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
                  515 520 525
          Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro
              530 535 540
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
          545 550 555 560
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                          565 570 575
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu
                      580 585 590
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr
                  595 600 605
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
              610 615 620
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
          625 630 635 640
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro
                          645 650 655
          Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                      660 665 670
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
                  675 680 685
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro
              690 695 700
          Thr Ser Thr Glu Ala His His His
          705 710
           <![CDATA[ <210> 647]]>
           <![CDATA[ <211> 864]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 647]]>
          Gly Ser Pro Gly Ala Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
          1 5 10 15
          Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                      20 25 30
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro
                  35 40 45
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
              50 55 60
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
          65 70 75 80
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
                          85 90 95
          Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
                      100 105 110
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
                  115 120 125
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
              130 135 140
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
          145 150 155 160
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
                          165 170 175
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser
                      180 185 190
          Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  195 200 205
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
              210 215 220
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
          225 230 235 240
          Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                          245 250 255
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                      260 265 270
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr
                  275 280 285
          Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
              290 295 300
          Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu
          305 310 315 320
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr
                          325 330 335
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                      340 345 350
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                  355 360 365
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser
              370 375 380
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
          385 390 395 400
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro
                          405 410 415
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser
                      420 425 430
          Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  435 440 445
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
              450 455 460
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
          465 470 475 480
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                          485 490 495
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                      500 505 510
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro
                  515 520 525
          Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
              530 535 540
          Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
          545 550 555 560
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
                          565 570 575
          Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                      580 585 590
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
                  595 600 605
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
              610 615 620
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
          625 630 635 640
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro
                          645 650 655
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
                      660 665 670
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
                  675 680 685
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro
              690 695 700
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro
          705 710 715 720
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
                          725 730 735
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                      740 745 750
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr
                  755 760 765
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
              770 775 780
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro
          785 790 795 800
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser
                          805 810 815
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                      820 825 830
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
                  835 840 845
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Glu Ser Ala Ser Arg
              850 855 860
           <![CDATA[ <210> 648]]>
           <![CDATA[ <211> 288]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 648]]>
          Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser
          1 5 10 15
          Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly
                      20 25 30
          Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly
                  35 40 45
          Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser
              50 55 60
          Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser
          65 70 75 80
          Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly
                          85 90 95
          Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly
                      100 105 110
          Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu
                  115 120 125
          Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
              130 135 140
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly
          145 150 155 160
          Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser
                          165 170 175
          Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
                      180 185 190
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser
                  195 200 205
          Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu
              210 215 220
          Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
          225 230 235 240
          Ser Glu Pro Ala Thr Ser Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly
                          245 250 255
          Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Thr Glu Gly
                      260 265 270
          Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
                  275 280 285
           <![CDATA[ <210> 649]]>
           <![CDATA[ <211> 284]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 649]]>
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro
          1 5 10 15
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro
                      20 25 30
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro
                  35 40 45
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Ser Thr
              50 55 60
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr
          65 70 75 80
          Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                          85 90 95
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu
                      100 105 110
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr
                  115 120 125
          Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
              130 135 140
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu
          145 150 155 160
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Ser Glu Ser Ala Thr Pro
                          165 170 175
          Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                      180 185 190
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro
                  195 200 205
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr
              210 215 220
          Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala Pro
          225 230 235 240
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro
                          245 250 255
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro
                      260 265 270
          Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu
                  275 280
           <![CDATA[ <210> 650]]>
           <![CDATA[ <211> 292]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 650]]>
          Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser
          1 5 10 15
          Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly
                      20 25 30
          Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly
                  35 40 45
          Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser
              50 55 60
          Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser
          65 70 75 80
          Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly
                          85 90 95
          Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly
                      100 105 110
          Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu
                  115 120 125
          Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
              130 135 140
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly
          145 150 155 160
          Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser
                          165 170 175
          Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
                      180 185 190
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser
                  195 200 205
          Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu
              210 215 220
          Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
          225 230 235 240
          Ser Glu Pro Ala Thr Ser Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly
                          245 250 255
          Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Thr Glu Gly
                      260 265 270
          Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
                  275 280 285
          Gly Ser Ala Pro
              290
           <![CDATA[ <210> 651]]>
           <![CDATA[ <211> 864]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 651]]>
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
          1 5 10 15
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                      20 25 30
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
                  35 40 45
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser
              50 55 60
          Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
          65 70 75 80
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu
                          85 90 95
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro
                      100 105 110
          Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  115 120 125
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
              130 135 140
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro
          145 150 155 160
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
                          165 170 175
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                      180 185 190
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
                  195 200 205
          Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
              210 215 220
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
          225 230 235 240
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser
                          245 250 255
          Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                      260 265 270
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro
                  275 280 285
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
              290 295 300
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
          305 310 315 320
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                          325 330 335
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser
                      340 345 350
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                  355 360 365
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
              370 375 380
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser
          385 390 395 400
          Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
                          405 410 415
          Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                      420 425 430
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
                  435 440 445
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
              450 455 460
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
          465 470 475 480
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
                          485 490 495
          Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                      500 505 510
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro
                  515 520 525
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro
              530 535 540
          Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
          545 550 555 560
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                          565 570 575
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
                      580 585 590
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  595 600 605
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
              610 615 620
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
          625 630 635 640
          Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
                          645 650 655
          Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu
                      660 665 670
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr
                  675 680 685
          Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
              690 695 700
          Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
          705 710 715 720
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
                          725 730 735
          Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                      740 745 750
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu
                  755 760 765
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser
              770 775 780
          Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
          785 790 795 800
          Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                          805 810 815
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro Ala Thr Ser
                      820 825 830
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  835 840 845
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ala Ala Glu Pro Glu Ala
              850 855 860
           <![CDATA[ <210> 652]]>
           <![CDATA[ <211> 867]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 652]]>
          Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu
          1 5 10 15
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu
                      20 25 30
          Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
                  35 40 45
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Ser Thr
              50 55 60
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro
          65 70 75 80
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro
                          85 90 95
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala
                      100 105 110
          Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro
                  115 120 125
          Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
              130 135 140
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala
          145 150 155 160
          Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu
                          165 170 175
          Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
                      180 185 190
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Ser Thr
                  195 200 205
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro
              210 215 220
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro
          225 230 235 240
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Ser Thr
                          245 250 255
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro
                      260 265 270
          Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                  275 280 285
          Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu
              290 295 300
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly
          305 310 315 320
          Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                          325 330 335
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Ser Thr
                      340 345 350
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu
                  355 360 365
          Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
              370 375 380
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Ser Thr
          385 390 395 400
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr
                          405 410 415
          Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala Pro
                      420 425 430
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro
                  435 440 445
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro
              450 455 460
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro
          465 470 475 480
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Ser Thr
                          485 490 495
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro
                      500 505 510
          Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
                  515 520 525
          Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala
              530 535 540
          Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro
          545 550 555 560
          Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
                          565 570 575
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro
                      580 585 590
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro
                  595 600 605
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro
              610 615 620
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Ser Thr
          625 630 635 640
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr
                          645 650 655
          Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                      660 665 670
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu
                  675 680 685
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr
              690 695 700
          Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
          705 710 715 720
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu
                          725 730 735
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Ser Glu Ser Ala Thr Pro
                      740 745 750
          Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                  755 760 765
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro
              770 775 780
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr
          785 790 795 800
          Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala Pro
                          805 810 815
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro
                      820 825 830
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro
                  835 840 845
          Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ala Ala Glu
              850 855 860
          Pro Glu Ala
          865
           <![CDATA[ <210> 653]]>
           <![CDATA[ <211> 867]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 653]]>
          Ser Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr
          1 5 10 15
          Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro
                      20 25 30
          Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Ser Thr
                  35 40 45
          Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr
              50 55 60
          Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala
          65 70 75 80
          Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu
                          85 90 95
          Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser
                      100 105 110
          Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala
                  115 120 125
          Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser
              130 135 140
          Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser
          145 150 155 160
          Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro
                          165 170 175
          Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser
                      180 185 190
          Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr
                  195 200 205
          Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala
              210 215 220
          Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu
          225 230 235 240
          Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr
                          245 250 255
          Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala
                      260 265 270
          Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser
                  275 280 285
          Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr
              290 295 300
          Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr
          305 310 315 320
          Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser
                          325 330 335
          Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr
                      340 345 350
          Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro
                  355 360 365
          Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser
              370 375 380
          Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr
          385 390 395 400
          Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser
                          405 410 415
          Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser
                      420 425 430
          Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser
                  435 440 445
          Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala
              450 455 460
          Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu
          465 470 475 480
          Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr
                          485 490 495
          Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala
                      500 505 510
          Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr
                  515 520 525
          Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser
              530 535 540
          Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala
          545 550 555 560
          Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser
                          565 570 575
          Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser
                      580 585 590
          Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala
                  595 600 605
          Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu
              610 615 620
          Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr
          625 630 635 640
          Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser
                          645 650 655
          Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser
                      660 665 670
          Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                  675 680 685
          Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser
              690 695 700
          Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr
          705 710 715 720
          Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr
                          725 730 735
          Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala
                      740 745 750
          Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser
                  755 760 765
          Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser
              770 775 780
          Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser
          785 790 795 800
          Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser
                          805 810 815
          Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser
                      820 825 830
          Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala
                  835 840 845
          Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser
              850 855 860
          Ala Pro Gly
          865
           <![CDATA[ <210> 654]]>
           <![CDATA[ <211> 868]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 654]]>
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
          1 5 10 15
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
                      20 25 30
          Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
                  35 40 45
          Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
              50 55 60
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
          65 70 75 80
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
                          85 90 95
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro
                      100 105 110
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
                  115 120 125
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
              130 135 140
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro
          145 150 155 160
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser
                          165 170 175
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                      180 185 190
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                  195 200 205
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
              210 215 220
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
          225 230 235 240
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                          245 250 255
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
                      260 265 270
          Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  275 280 285
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
              290 295 300
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
          305 310 315 320
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                          325 330 335
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                      340 345 350
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser
                  355 360 365
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
              370 375 380
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
          385 390 395 400
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro
                          405 410 415
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
                      420 425 430
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu
                  435 440 445
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr
              450 455 460
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
          465 470 475 480
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                          485 490 495
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
                      500 505 510
          Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
                  515 520 525
          Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro
              530 535 540
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
          545 550 555 560
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                          565 570 575
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu
                      580 585 590
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr
                  595 600 605
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
              610 615 620
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
          625 630 635 640
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro
                          645 650 655
          Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                      660 665 670
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
                  675 680 685
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro
              690 695 700
          Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
          705 710 715 720
          Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                          725 730 735
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr
                      740 745 750
          Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  755 760 765
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu
              770 775 780
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro
          785 790 795 800
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
                          805 810 815
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu
                      820 825 830
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr
                  835 840 845
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ala Ala
              850 855 860
          Glu Pro Glu Ala
          865
           <![CDATA[ <210> 655]]>
           <![CDATA[ <211> 144]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 655]]>
          Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu
          1 5 10 15
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu
                      20 25 30
          Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
                  35 40 45
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Ser Thr
              50 55 60
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro
          65 70 75 80
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro
                          85 90 95
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala
                      100 105 110
          Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro
                  115 120 125
          Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
              130 135 140
           <![CDATA[ <210> 656]]>
           <![CDATA[ <211> 292]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 656]]>
          Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser
          1 5 10 15
          Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly
                      20 25 30
          Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly
                  35 40 45
          Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser
              50 55 60
          Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser
          65 70 75 80
          Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly
                          85 90 95
          Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly
                      100 105 110
          Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu
                  115 120 125
          Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
              130 135 140
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly
          145 150 155 160
          Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser
                          165 170 175
          Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
                      180 185 190
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser
                  195 200 205
          Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu
              210 215 220
          Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
          225 230 235 240
          Ser Glu Pro Ala Thr Ser Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly
                          245 250 255
          Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Thr Glu Gly
                      260 265 270
          Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
                  275 280 285
          Gly Ser Ala Pro
              290
           <![CDATA[ <210> 657]]>
           <![CDATA[ <211> 293]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 657]]>
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
          1 5 10 15
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
                      20 25 30
          Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
                  35 40 45
          Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
              50 55 60
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
          65 70 75 80
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
                          85 90 95
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro
                      100 105 110
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
                  115 120 125
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
              130 135 140
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro
          145 150 155 160
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser
                          165 170 175
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                      180 185 190
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                  195 200 205
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
              210 215 220
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
          225 230 235 240
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                          245 250 255
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
                      260 265 270
          Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Gly Ala
                  275 280 285
          Ala Glu Pro Glu Ala
              290
           <![CDATA[ <210> 658]]>
           <![CDATA[ <211> 300]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 658]]>
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
          1 5 10 15
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
                      20 25 30
          Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
                  35 40 45
          Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
              50 55 60
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
          65 70 75 80
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
                          85 90 95
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro
                      100 105 110
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
                  115 120 125
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
              130 135 140
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro
          145 150 155 160
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser
                          165 170 175
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                      180 185 190
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                  195 200 205
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
              210 215 220
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
          225 230 235 240
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                          245 250 255
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
                      260 265 270
          Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  275 280 285
          Pro Gly Ser Pro Ala Gly Ala Ala Glu Pro Glu Ala
              290 295 300
           <![CDATA[ <210> 659]]>
           <![CDATA[ <211> 584]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 659]]>
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
          1 5 10 15
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
                      20 25 30
          Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
                  35 40 45
          Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
              50 55 60
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
          65 70 75 80
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
                          85 90 95
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro
                      100 105 110
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
                  115 120 125
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
              130 135 140
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro
          145 150 155 160
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser
                          165 170 175
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                      180 185 190
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                  195 200 205
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
              210 215 220
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
          225 230 235 240
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                          245 250 255
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
                      260 265 270
          Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  275 280 285
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
              290 295 300
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
          305 310 315 320
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                          325 330 335
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                      340 345 350
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser
                  355 360 365
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
              370 375 380
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
          385 390 395 400
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro
                          405 410 415
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
                      420 425 430
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu
                  435 440 445
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr
              450 455 460
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
          465 470 475 480
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                          485 490 495
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
                      500 505 510
          Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
                  515 520 525
          Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro
              530 535 540
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
          545 550 555 560
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                          565 570 575
          Pro Gly Ala Ala Glu Pro Glu Ala
                      580
           <![CDATA[ <210> 660]]>
           <![CDATA[ <400> 660]]>
          000
           <![CDATA[ <210> 661]]>
           <![CDATA[ <400> 661]]>
          000
           <![CDATA[ <210> 662]]>
           <![CDATA[ <400> 662]]>
          000
           <![CDATA[ <210> 663]]>
           <![CDATA[ <400> 663]]>
          000
           <![CDATA[ <210> 664]]>
           <![CDATA[ <400> 664]]>
          000
           <![CDATA[ <210> 665]]>
           <![CDATA[ <400> 665]]>
          000
           <![CDATA[ <210> 666]]>
           <![CDATA[ <400> 666]]>
          000
           <![CDATA[ <210> 667]]>
           <![CDATA[ <400> 667]]>
          000
           <![CDATA[ <210> 668]]>
           <![CDATA[ <400> 668]]>
          000
           <![CDATA[ <210> 669]]>
           <![CDATA[ <400> 669]]>
          000
           <![CDATA[ <210> 670]]>
           <![CDATA[ <400> 670]]>
          000
           <![CDATA[ <210> 671]]>
           <![CDATA[ <400> 671]]>
          000
           <![CDATA[ <210> 672]]>
           <![CDATA[ <400> 672]]>
          000
           <![CDATA[ <210> 673]]>
           <![CDATA[ <400> 673]]>
          000
           <![CDATA[ <210> 674]]>
           <![CDATA[ <400> 674]]>
          000
           <![CDATA[ <210> 675]]>
           <![CDATA[ <400> 675]]>
          000
           <![CDATA[ <210> 676]]>
           <![CDATA[ <211> 144]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 676]]>
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu
          1 5 10 15
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly
                      20 25 30
          Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
                  35 40 45
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro
              50 55 60
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly
          65 70 75 80
          Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro
                          85 90 95
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu
                      100 105 110
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly
                  115 120 125
          Ser Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
              130 135 140
           <![CDATA[ <210> 677]]>
           <![CDATA[ <211> 288]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 677]]>
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro
          1 5 10 15
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro
                      20 25 30
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro
                  35 40 45
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Ser Thr
              50 55 60
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr
          65 70 75 80
          Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                          85 90 95
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu
                      100 105 110
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr
                  115 120 125
          Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
              130 135 140
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu
          145 150 155 160
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Ser Glu Ser Ala Thr Pro
                          165 170 175
          Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                      180 185 190
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro
                  195 200 205
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr
              210 215 220
          Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala Pro
          225 230 235 240
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro
                          245 250 255
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro
                      260 265 270
          Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
                  275 280 285
           <![CDATA[ <210> 678]]>
           <![CDATA[ <211> 576]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 678]]>
          Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu
          1 5 10 15
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu
                      20 25 30
          Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
                  35 40 45
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Ser Thr
              50 55 60
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro
          65 70 75 80
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro
                          85 90 95
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala
                      100 105 110
          Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro
                  115 120 125
          Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
              130 135 140
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala
          145 150 155 160
          Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu
                          165 170 175
          Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
                      180 185 190
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Ser Thr
                  195 200 205
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro
              210 215 220
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro
          225 230 235 240
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Ser Thr
                          245 250 255
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro
                      260 265 270
          Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                  275 280 285
          Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu
              290 295 300
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly
          305 310 315 320
          Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                          325 330 335
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Ser Thr
                      340 345 350
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu
                  355 360 365
          Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
              370 375 380
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Ser Thr
          385 390 395 400
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr
                          405 410 415
          Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala Pro
                      420 425 430
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro
                  435 440 445
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro
              450 455 460
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro
          465 470 475 480
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Ser Thr
                          485 490 495
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro
                      500 505 510
          Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
                  515 520 525
          Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala
              530 535 540
          Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro
          545 550 555 560
          Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
                          565 570 575
           <![CDATA[ <210> 679]]>
           <![CDATA[ <211> 864]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 679]]>
          Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu
          1 5 10 15
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu
                      20 25 30
          Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
                  35 40 45
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Ser Thr
              50 55 60
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro
          65 70 75 80
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro
                          85 90 95
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala
                      100 105 110
          Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro
                  115 120 125
          Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
              130 135 140
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala
          145 150 155 160
          Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu
                          165 170 175
          Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
                      180 185 190
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Ser Thr
                  195 200 205
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro
              210 215 220
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro
          225 230 235 240
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Ser Thr
                          245 250 255
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro
                      260 265 270
          Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                  275 280 285
          Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu
              290 295 300
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly
          305 310 315 320
          Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                          325 330 335
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Ser Thr
                      340 345 350
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu
                  355 360 365
          Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
              370 375 380
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Ser Thr
          385 390 395 400
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr
                          405 410 415
          Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala Pro
                      420 425 430
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro
                  435 440 445
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro
              450 455 460
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro
          465 470 475 480
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Ser Thr
                          485 490 495
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro
                      500 505 510
          Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
                  515 520 525
          Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala
              530 535 540
          Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro
          545 550 555 560
          Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
                          565 570 575
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro
                      580 585 590
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro
                  595 600 605
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro
              610 615 620
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Ser Thr
          625 630 635 640
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr
                          645 650 655
          Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                      660 665 670
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu
                  675 680 685
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr
              690 695 700
          Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
          705 710 715 720
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu
                          725 730 735
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Ser Glu Ser Ala Thr Pro
                      740 745 750
          Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                  755 760 765
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro
              770 775 780
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr
          785 790 795 800
          Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala Pro
                          805 810 815
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro
                      820 825 830
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro
                  835 840 845
          Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
              850 855 860
           <![CDATA[ <210> 680]]>
           <![CDATA[ <400> 680]]>
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           <![CDATA[ <210> 681]]>
           <![CDATA[ <400> 681]]>
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           <![CDATA[ <400> 682]]>
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           <![CDATA[ <400> 690]]>
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           <![CDATA[ <400> 692]]>
          000
           <![CDATA[ <210> 693]]>
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          000
           <![CDATA[ <210> 694]]>
           <![CDATA[ <400> 694]]>
          000
           <![CDATA[ <210> 695]]>
           <![CDATA[ <400> 695]]>
          000
           <![CDATA[ <210> 696]]>
           <![CDATA[ <400> 696]]>
          000
           <![CDATA[ <210> 697]]>
           <![CDATA[ <400> 697]]>
          000
           <![CDATA[ <210> 698]]>
           <![CDATA[ <400> 698]]>
          000
           <![CDATA[ <210> 699]]>
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          000
           <![CDATA[ <210> 700]]>
           <![CDATA[ <400> 700]]>
          000
           <![CDATA[ <210> 701]]>
           <![CDATA[ <400> 701]]>
          000
           <![CDATA[ <210> 702]]>
           <![CDATA[ <400> 702]]>
          000
           <![CDATA[ <210> 703]]>
           <![CDATA[ <400> 703]]>
          000
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           <![CDATA[ <400> 704]]>
          000
           <![CDATA[ <210> 705]]>
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          000
           <![CDATA[ <210> 706]]>
           <![CDATA[ <400> 706]]>
          000
           <![CDATA[ <210> 707]]>
           <![CDATA[ <400> 707]]>
          000
           <![CDATA[ <210> 708]]>
           <![CDATA[ <400> 708]]>
          000
           <![CDATA[ <210> 709]]>
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          000
           <![CDATA[ <210> 710]]>
           <![CDATA[ <400> 710]]>
          000
           <![CDATA[ <210> 711]]>
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          000
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           <![CDATA[ <400> 712]]>
          000
           <![CDATA[ <210> 713]]>
           <![CDATA[ <400> 713]]>
          000
           <![CDATA[ <210> 714]]>
           <![CDATA[ <400> 714]]>
          000
           <![CDATA[ <210> 715]]>
           <![CDATA[ <400> 715]]>
          000
           <![CDATA[ <210> 716]]>
           <![CDATA[ <400> 716]]>
          000
           <![CDATA[ <210> 717]]>
           <![CDATA[ <400> 717]]>
          000
           <![CDATA[ <210> 718]]>
           <![CDATA[ <400> 718]]>
          000
           <![CDATA[ <210> 719]]>
           <![CDATA[ <400> 719]]>
          000
           <![CDATA[ <210> 720]]>
           <![CDATA[ <400> 720]]>
          000
           <![CDATA[ <210> 721]]>
           <![CDATA[ <400> 721]]>
          000
           <![CDATA[ <210> 722]]>
           <![CDATA[ <400> 722]]>
          000
           <![CDATA[ <210> 723]]>
           <![CDATA[ <400> 723]]>
          000
           <![CDATA[ <210> 724]]>
           <![CDATA[ <400> 724]]>
          000
           <![CDATA[ <210> 725]]>
           <![CDATA[ <400> 725]]>
          000
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           <![CDATA[ <400> 726]]>
          000
           <![CDATA[ <210> 727]]>
           <![CDATA[ <400> 727]]>
          000
           <![CDATA[ <210> 728]]>
           <![CDATA[ <400> 728]]>
          000
           <![CDATA[ <210> 729]]>
           <![CDATA[ <400> 729]]>
          000
           <![CDATA[ <210> 730]]>
           <![CDATA[ <400> 730]]>
          000
           <![CDATA[ <210> 731]]>
           <![CDATA[ <400> 731]]>
          000
           <![CDATA[ <210> 732]]>
           <![CDATA[ <400> 732]]>
          000
           <![CDATA[ <210> 733]]>
           <![CDATA[ <400> 733]]>
          000
           <![CDATA[ <210> 734]]>
           <![CDATA[ <400> 734]]>
          000
           <![CDATA[ <210> 735]]>
           <![CDATA[ <400> 735]]>
          000
           <![CDATA[ <210> 736]]>
           <![CDATA[ <400> 736]]>
          000
           <![CDATA[ <210> 737]]>
           <![CDATA[ <400> 737]]>
          000
           <![CDATA[ <210> 738]]>
           <![CDATA[ <400> 738]]>
          000
           <![CDATA[ <210> 739]]>
           <![CDATA[ <400> 739]]>
          000
           <![CDATA[ <210> 740]]>
           <![CDATA[ <400> 740]]>
          000
           <![CDATA[ <210> 741]]>
           <![CDATA[ <400> 741]]>
          000
           <![CDATA[ <210> 742]]>
           <![CDATA[ <400> 742]]>
          000
           <![CDATA[ <210> 743]]>
           <![CDATA[ <400> 743]]>
          000
           <![CDATA[ <210> 744]]>
           <![CDATA[ <400> 744]]>
          000
           <![CDATA[ <210> 745]]>
           <![CDATA[ <400> 745]]>
          000
           <![CDATA[ <210> 746]]>
           <![CDATA[ <400> 746]]>
          000
           <![CDATA[ <210> 747]]>
           <![CDATA[ <400> 747]]>
          000
           <![CDATA[ <210> 748]]>
           <![CDATA[ <400> 748]]>
          000
           <![CDATA[ <210> 749]]>
           <![CDATA[ <400> 749]]>
          000
           <![CDATA[ <210> 750]]>
           <![CDATA[ <400> 750]]>
          000
           <![CDATA[ <210> 751]]>
           <![CDATA[ <400> 751]]>
          000
           <![CDATA[ <210> 752]]>
           <![CDATA[ <400> 752]]>
          000
           <![CDATA[ <210> 753]]>
           <![CDATA[ <400> 753]]>
          000
           <![CDATA[ <210> 754]]>
           <![CDATA[ <400> 754]]>
          000
           <![CDATA[ <210> 755]]>
           <![CDATA[ <400> 755]]>
          000
           <![CDATA[ <210> 756]]>
           <![CDATA[ <400> 756]]>
          000
           <![CDATA[ <210> 757]]>
           <![CDATA[ <400> 757]]>
          000
           <![CDATA[ <210> 758]]>
           <![CDATA[ <400> 758]]>
          000
           <![CDATA[ <210> 759]]>
           <![CDATA[ <400> 759]]>
          000
           <![CDATA[ <210> 760]]>
           <![CDATA[ <400> 760]]>
          000
           <![CDATA[ <210> 761]]>
           <![CDATA[ <400> 761]]>
          000
           <![CDATA[ <210> 762]]>
           <![CDATA[ <400> 762]]>
          000
           <![CDATA[ <210> 763]]>
           <![CDATA[ <400> 763]]>
          000
           <![CDATA[ <210> 764]]>
           <![CDATA[ <400> 764]]>
          000
           <![CDATA[ <210> 765]]>
           <![CDATA[ <400> 765]]>
          000
           <![CDATA[ <210> 766]]>
           <![CDATA[ <400> 766]]>
          000
           <![CDATA[ <210> 767]]>
           <![CDATA[ <400> 767]]>
          000
           <![CDATA[ <210> 768]]>
           <![CDATA[ <400> 768]]>
          000
           <![CDATA[ <210> 769]]>
           <![CDATA[ <400> 769]]>
          000
           <![CDATA[ <210> 770]]>
           <![CDATA[ <400> 770]]>
          000
           <![CDATA[ <210> 771]]>
           <![CDATA[ <400> 771]]>
          000
           <![CDATA[ <210> 772]]>
           <![CDATA[ <400> 772]]>
          000
           <![CDATA[ <210> 773]]>
           <![CDATA[ <400> 773]]>
          000
           <![CDATA[ <210> 774]]>
           <![CDATA[ <400> 774]]>
          000
           <![CDATA[ <210> 775]]>
           <![CDATA[ <400> 775]]>
          000
           <![CDATA[ <210> 776]]>
           <![CDATA[ <400> 776]]>
          000
           <![CDATA[ <210> 777]]>
           <![CDATA[ <400> 777]]>
          000
           <![CDATA[ <210> 778]]>
           <![CDATA[ <211> 119]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 778]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
          1 5 10 15
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
                      20 25 30
          Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
                  35 40 45
          Ser Ser Ile Ser Gly Ser Ser Arg Tyr Ile Tyr Tyr Ala Asp Ser Val
              50 55 60
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
          65 70 75 80
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                          85 90 95
          Ala Lys Met Asp Ala Ser Gly Ser Tyr Phe Asn Phe Trp Gly Gln Gly
                      100 105 110
          Thr Leu Val Thr Val Ser Ser
                  115
           <![CDATA[ <210> 779]]>
           <![CDATA[ <211> 115]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 779]]>
          Gln Val Gln Leu Leu Gln Ser Ala Ala Glu Val Lys Lys Pro Gly Glu
          1 5 10 15
          Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr
                      20 25 30
          Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
                  35 40 45
          Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe
              50 55 60
          Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
          65 70 75 80
          Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Val Tyr Tyr Cys
                          85 90 95
          Ala Arg Trp Arg Asp Ser Pro Leu Trp Gly Gln Gly Thr Leu Val Thr
                      100 105 110
          Val Ser Ser
                  115
           <![CDATA[ <210> 780]]>
           <![CDATA[ <211> 120]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 780]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
          1 5 10 15
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr
                      20 25 30
          Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
                  35 40 45
          Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val
              50 55 60
          Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
          65 70 75 80
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                          85 90 95
          Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln
                      100 105 110
          Gly Thr Leu Val Thr Val Ser Ser
                  115 120
           <![CDATA[ <210> 781]]>
           <![CDATA[ <211> 120]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 781]]>
          Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
          1 5 10 15
          Ser Leu Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Thr
                      20 25 30
          Tyr Ile His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile
                  35 40 45
          Gly Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Asp Pro Lys Phe
              50 55 60
          Gln Asp Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Ser Asn Thr Ala Tyr
          65 70 75 80
          Leu Gln Val Ser Arg Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                          85 90 95
          Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln
                      100 105 110
          Gly Ala Ser Val Thr Val Ser Ser
                  115 120
           <![CDATA[ <210> 782]]>
           <![CDATA[ <211> 119]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 782]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
          1 5 10 15
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Tyr
                      20 25 30
          Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
                  35 40 45
          Ser Ala Ile Ser Gly Arg Gly Asp Asn Thr Tyr Tyr Ala Asp Ser Val
              50 55 60
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
          65 70 75 80
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                          85 90 95
          Ala Lys Met Thr Ser Asn Ala Phe Ala Phe Asp Tyr Trp Gly Gln Gly
                      100 105 110
          Thr Leu Val Thr Val Ser Ser
                  115
           <![CDATA[ <210> 783]]>
           <![CDATA[ <211> 119]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 783]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
          1 5 10 15
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr
                      20 25 30
          Thr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
                  35 40 45
          Ala Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Tyr Asn Gln Arg Phe
              50 55 60
          Lys Gly Arg Phe Thr Leu Ser Val Asp Arg Ser Lys Asn Thr Leu Tyr
          65 70 75 80
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                          85 90 95
          Ala Arg Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr Trp Gly Gln Gly
                      100 105 110
          Thr Leu Val Thr Val Ser Ser
                  115
           <![CDATA[ <210> 784]]>
           <![CDATA[ <400> 784]]>
          000
           <![CDATA[ <210> 785]]>
           <![CDATA[ <400> 785]]>
          000
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           <![CDATA[ <400> 786]]>
          000
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           <![CDATA[ <400> 787]]>
          000
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           <![CDATA[ <400> 788]]>
          000
           <![CDATA[ <210> 789]]>
           <![CDATA[ <400> 789]]>
          000
           <![CDATA[ <210> 790]]>
           <![CDATA[ <400> 790]]>
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           <![CDATA[ <400> 791]]>
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           <![CDATA[ <400> 792]]>
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           <![CDATA[ <400> 793]]>
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           <![CDATA[ <400> 795]]>
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           <![CDATA[ <400> 800]]>
          000
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          000
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           <![CDATA[ <400> 802]]>
          000
           <![CDATA[ <210> 803]]>
           <![CDATA[ <400> 803]]>
          000
           <![CDATA[ <210> 804]]>
           <![CDATA[ <400> 804]]>
          000
           <![CDATA[ <210> 805]]>
           <![CDATA[ <400> 805]]>
          000
           <![CDATA[ <210> 806]]>
           <![CDATA[ <400> 806]]>
          000
           <![CDATA[ <210> 807]]>
           <![CDATA[ <400> 807]]>
          000
           <![CDATA[ <210> 808]]>
           <![CDATA[ <400> 808]]>
          000
           <![CDATA[ <210> 809]]>
           <![CDATA[ <400> 809]]>
          000
           <![CDATA[ <210> 810]]>
           <![CDATA[ <400> 810]]>
          000
           <![CDATA[ <210> 811]]>
           <![CDATA[ <400> 811]]>
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          Gln Ser Pro Ser Phe Leu Ser Ala Phe Val Gly Asp Arg Ile Thr Ile
          1 5 10 15
          Thr Cys Arg Ala Ser Pro Gly Ile Arg Asn Tyr Leu Ala Trp Tyr Gln
                      20 25 30
          Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Thr
                  35 40 45
          Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr
              50 55 60
          Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr
          65 70 75 80
          Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu Ser Phe Gly Gly Gly
                          85 90 95
          Thr Lys Val Glu Ile Lys
                      100
           <![CDATA[ <210> 879]]>
           <![CDATA[ <211> 110]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 879]]>
          Gln Ala Val Val Thr Gln Glu Pro Ser Phe Ser Val Ser Pro Gly Gly
          1 5 10 15
          Thr Val Thr Leu Thr Cys Gly Leu Ser Ser Gly Ser Val Ser Thr Ser
                      20 25 30
          Tyr Tyr Pro Ser Trp Tyr Gln Gln Thr Pro Gly Gln Ala Pro Arg Thr
                  35 40 45
          Leu Ile Tyr Ser Thr Asn Thr Arg Ser Ser Gly Val Pro Asp Arg Phe
              50 55 60
          Ser Gly Ser Ile Leu Gly Asn Lys Ala Ala Leu Thr Ile Thr Gly Ala
          65 70 75 80
          Gln Ala Asp Asp Glu Ser Asp Tyr Tyr Cys Val Leu Tyr Met Gly Ser
                          85 90 95
          Gly Gln Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
                      100 105 110
           <![CDATA[ <210> 880]]>
           <![CDATA[ <211> 107]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 880]]>
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          1 5 10 15
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                      20 25 30
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                  35 40 45
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              50 55 60
          Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
          65 70 75 80
          Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro
                          85 90 95
          Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
                      100 105
           <![CDATA[ <210> 881]]>
           <![CDATA[ <211> 107]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 881]]>
          Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly
          1 5 10 15
          Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Asn Thr Ala
                      20 25 30
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                  35 40 45
          Tyr Ser Ala Ser Phe Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly
              50 55 60
          Ser Arg Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala
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          Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro
                          85 90 95
          Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
                      100 105
           <![CDATA[ <210> 882]]>
           <![CDATA[ <211> 111]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 882]]>
          Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
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          Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly
                      20 25 30
          Tyr Gly Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu
                  35 40 45
          Leu Ile Tyr Gly Asn Thr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
              50 55 60
          Ser Gly Phe Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
          65 70 75 80
          Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Phe Tyr Asp Ser Ser
                          85 90 95
          Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
                      100 105 110
           <![CDATA[ <210> 883]]>
           <![CDATA[ <211> 107]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 883]]>
          Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
          1 5 10 15
          Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ile Gly
                      20 25 30
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                  35 40 45
          Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly
              50 55 60
          Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
          65 70 75 80
          Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ile Tyr Pro Tyr
                          85 90 95
          Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
                      100 105
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          Gly Thr Ser Glu Pro Ser Thr Ser Glu Pro Gly Ala
          1 5 10
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          Gly Thr Ser Thr Glu Pro Ser Glu Pro Gly Ser Ala
          1 5 10
           <![CDATA[ <210> 1719]]>
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          Gly Ser Thr Ala Gly Ser Glu Thr Ser Thr Glu Ala
          1 5 10
           <![CDATA[ <210> 1720]]>
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          Gly Ser Glu Thr Ala Thr Ser Gly Ser Glu Thr Ala
          1 5 10
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           <![CDATA[ <400> 1721]]>
          Gly Thr Ser Glu Ser Ala Thr Ser Glu Ser Gly Ala
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           <![CDATA[ <400> 6741]]>
          000
           <![CDATA[ <210> 6742]]>
           <![CDATA[ <400> 6742]]>
          000
           <![CDATA[ <210> 6743]]>
           <![CDATA[ <400> 6743]]>
          000
           <![CDATA[ <210> 6744]]>
           <![CDATA[ <400> 6744]]>
          000
           <![CDATA[ <210> 6745]]>
           <![CDATA[ <400> 6745]]>
          000
           <![CDATA[ <210> 6746]]>
           <![CDATA[ <400> 6746]]>
          000
           <![CDATA[ <210> 6747]]>
           <![CDATA[ <400> 6747]]>
          000
           <![CDATA[ <210> 6748]]>
           <![CDATA[ <400> 6748]]>
          000
           <![CDATA[ <210> 6749]]>
           <![CDATA[ <400> 6749]]>
          000
           <![CDATA[ <210> 6750]]>
           <![CDATA[ <400> 6750]]>
          000
           <![CDATA[ <210> 6751]]>
           <![CDATA[ <400> 6751]]>
          000
           <![CDATA[ <210> 6752]]>
           <![CDATA[ <400> 6752]]>
          000
           <![CDATA[ <210> 6753]]>
           <![CDATA[ <400> 6753]]>
          000
           <![CDATA[ <210> 6754]]>
           <![CDATA[ <400> 6754]]>
          000
           <![CDATA[ <210> 6755]]>
           <![CDATA[ <400> 6755]]>
          000
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           <![CDATA[ <400> 6756]]>
          000
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           <![CDATA[ <400> 6757]]>
          000
           <![CDATA[ <210> 6758]]>
           <![CDATA[ <400> 6758]]>
          000
           <![CDATA[ <210> 6759]]>
           <![CDATA[ <400> 6759]]>
          000
           <![CDATA[ <210> 6760]]>
           <![CDATA[ <400> 6760]]>
          000
           <![CDATA[ <210> 6761]]>
           <![CDATA[ <400> 6761]]>
          000
           <![CDATA[ <210> 6762]]>
           <![CDATA[ <400> 6762]]>
          000
           <![CDATA[ <210> 6763]]>
           <![CDATA[ <400> 6763]]>
          000
           <![CDATA[ <210> 6764]]>
           <![CDATA[ <400> 6764]]>
          000
           <![CDATA[ <210> 6765]]>
           <![CDATA[ <400> 6765]]>
          000
           <![CDATA[ <210> 6766]]>
           <![CDATA[ <400> 6766]]>
          000
           <![CDATA[ <210> 6767]]>
           <![CDATA[ <400> 6767]]>
          000
           <![CDATA[ <210> 6768]]>
           <![CDATA[ <400> 6768]]>
          000
           <![CDATA[ <210> 6769]]>
           <![CDATA[ <400> 6769]]>
          000
           <![CDATA[ <210> 6770]]>
           <![CDATA[ <400> 6770]]>
          000
           <![CDATA[ <210> 6771]]>
           <![CDATA[ <400> 6771]]>
          000
           <![CDATA[ <210> 6772]]>
           <![CDATA[ <400> 6772]]>
          000
           <![CDATA[ <210> 6773]]>
           <![CDATA[ <400> 6773]]>
          000
           <![CDATA[ <210> 6774]]>
           <![CDATA[ <400> 6774]]>
          000
           <![CDATA[ <210> 6775]]>
           <![CDATA[ <400> 6775]]>
          000
           <![CDATA[ <210> 6776]]>
           <![CDATA[ <400> 6776]]>
          000
           <![CDATA[ <210> 6777]]>
           <![CDATA[ <400> 6777]]>
          000
           <![CDATA[ <210> 6778]]>
           <![CDATA[ <400> 6778]]>
          000
           <![CDATA[ <210> 6779]]>
           <![CDATA[ <400> 6779]]>
          000
           <![CDATA[ <210> 6780]]>
           <![CDATA[ <400> 6780]]>
          000
           <![CDATA[ <210> 6781]]>
           <![CDATA[ <400> 6781]]>
          000
           <![CDATA[ <210> 6782]]>
           <![CDATA[ <400> 6782]]>
          000
           <![CDATA[ <210> 6783]]>
           <![CDATA[ <400> 6783]]>
          000
           <![CDATA[ <210> 6784]]>
           <![CDATA[ <400> 6784]]>
          000
           <![CDATA[ <210> 6785]]>
           <![CDATA[ <400> 6785]]>
          000
           <![CDATA[ <210> 6786]]>
           <![CDATA[ <400> 6786]]>
          000
           <![CDATA[ <210> 6787]]>
           <![CDATA[ <400> 6787]]>
          000
           <![CDATA[ <210> 6788]]>
           <![CDATA[ <400> 6788]]>
          000
           <![CDATA[ <210> 6789]]>
           <![CDATA[ <400> 6789]]>
          000
           <![CDATA[ <210> 6790]]>
           <![CDATA[ <400> 6790]]>
          000
           <![CDATA[ <210> 6791]]>
           <![CDATA[ <400> 6791]]>
          000
           <![CDATA[ <210> 6792]]>
           <![CDATA[ <400> 6792]]>
          000
           <![CDATA[ <210> 6793]]>
           <![CDATA[ <400> 6793]]>
          000
           <![CDATA[ <210> 6794]]>
           <![CDATA[ <400> 6794]]>
          000
           <![CDATA[ <210> 6795]]>
           <![CDATA[ <400> 6795]]>
          000
           <![CDATA[ <210> 6796]]>
           <![CDATA[ <400> 6796]]>
          000
           <![CDATA[ <210> 6797]]>
           <![CDATA[ <400> 6797]]>
          000
           <![CDATA[ <210> 6798]]>
           <![CDATA[ <400> 6798]]>
          000
           <![CDATA[ <210> 6799]]>
           <![CDATA[ <400> 6799]]>
          000
           <![CDATA[ <210> 6800]]>
           <![CDATA[ <400> 6800]]>
          000
           <![CDATA[ <210> 6801]]>
           <![CDATA[ <400> 6801]]>
          000
           <![CDATA[ <210> 6802]]>
           <![CDATA[ <400> 6802]]>
          000
           <![CDATA[ <210> 6803]]>
           <![CDATA[ <400> 6803]]>
          000
           <![CDATA[ <210> 6804]]>
           <![CDATA[ <400> 6804]]>
          000
           <![CDATA[ <210> 6805]]>
           <![CDATA[ <400> 6805]]>
          000
           <![CDATA[ <210> 6806]]>
           <![CDATA[ <400> 6806]]>
          000
           <![CDATA[ <210> 6807]]>
           <![CDATA[ <400> 6807]]>
          000
           <![CDATA[ <210> 6808]]>
           <![CDATA[ <400> 6808]]>
          000
           <![CDATA[ <210> 6809]]>
           <![CDATA[ <400> 6809]]>
          000
           <![CDATA[ <210> 6810]]>
           <![CDATA[ <400> 6810]]>
          000
           <![CDATA[ <210> 6811]]>
           <![CDATA[ <400> 6811]]>
          000
           <![CDATA[ <210> 6812]]>
           <![CDATA[ <400> 6812]]>
          000
           <![CDATA[ <210> 6813]]>
           <![CDATA[ <400> 6813]]>
          000
           <![CDATA[ <210> 6814]]>
           <![CDATA[ <400> 6814]]>
          000
           <![CDATA[ <210> 6815]]>
           <![CDATA[ <400> 6815]]>
          000
           <![CDATA[ <210> 6816]]>
           <![CDATA[ <400> 6816]]>
          000
           <![CDATA[ <210> 6817]]>
           <![CDATA[ <400> 6817]]>
          000
           <![CDATA[ <210> 6818]]>
           <![CDATA[ <400> 6818]]>
          000
           <![CDATA[ <210> 6819]]>
           <![CDATA[ <400> 6819]]>
          000
           <![CDATA[ <210> 6820]]>
           <![CDATA[ <400> 6820]]>
          000
           <![CDATA[ <210> 6821]]>
           <![CDATA[ <400> 6821]]>
          000
           <![CDATA[ <210> 6822]]>
           <![CDATA[ <400> 6822]]>
          000
           <![CDATA[ <210> 6823]]>
           <![CDATA[ <400> 6823]]>
          000
           <![CDATA[ <210> 6824]]>
           <![CDATA[ <400> 6824]]>
          000
           <![CDATA[ <210> 6825]]>
           <![CDATA[ <400> 6825]]>
          000
           <![CDATA[ <210> 6826]]>
           <![CDATA[ <400> 6826]]>
          000
           <![CDATA[ <210> 6827]]>
           <![CDATA[ <400> 6827]]>
          000
           <![CDATA[ <210> 6828]]>
           <![CDATA[ <400> 6828]]>
          000
           <![CDATA[ <210> 6829]]>
           <![CDATA[ <400> 6829]]>
          000
           <![CDATA[ <210> 6830]]>
           <![CDATA[ <400> 6830]]>
          000
           <![CDATA[ <210> 6831]]>
           <![CDATA[ <400> 6831]]>
          000
           <![CDATA[ <210> 6832]]>
           <![CDATA[ <400> 6832]]>
          000
           <![CDATA[ <210> 6833]]>
           <![CDATA[ <400> 6833]]>
          000
           <![CDATA[ <210> 6834]]>
           <![CDATA[ <400> 6834]]>
          000
           <![CDATA[ <210> 6835]]>
           <![CDATA[ <400> 6835]]>
          000
           <![CDATA[ <210> 6836]]>
           <![CDATA[ <400> 6836]]>
          000
           <![CDATA[ <210> 6837]]>
           <![CDATA[ <400> 6837]]>
          000
           <![CDATA[ <210> 6838]]>
           <![CDATA[ <400> 6838]]>
          000
           <![CDATA[ <210> 6839]]>
           <![CDATA[ <400> 6839]]>
          000
           <![CDATA[ <210> 6840]]>
           <![CDATA[ <400> 6840]]>
          000
           <![CDATA[ <210> 6841]]>
           <![CDATA[ <400> 6841]]>
          000
           <![CDATA[ <210> 6842]]>
           <![CDATA[ <400> 6842]]>
          000
           <![CDATA[ <210> 6843]]>
           <![CDATA[ <400> 6843]]>
          000
           <![CDATA[ <210> 6844]]>
           <![CDATA[ <400> 6844]]>
          000
           <![CDATA[ <210> 6845]]>
           <![CDATA[ <400> 6845]]>
          000
           <![CDATA[ <210> 6846]]>
           <![CDATA[ <400> 6846]]>
          000
           <![CDATA[ <210> 6847]]>
           <![CDATA[ <400> 6847]]>
          000
           <![CDATA[ <210> 6848]]>
           <![CDATA[ <400> 6848]]>
          000
           <![CDATA[ <210> 6849]]>
           <![CDATA[ <400> 6849]]>
          000
           <![CDATA[ <210> 6850]]>
           <![CDATA[ <400> 6850]]>
          000
           <![CDATA[ <210> 6851]]>
           <![CDATA[ <400> 6851]]>
          000
           <![CDATA[ <210> 6852]]>
           <![CDATA[ <400> 6852]]>
          000
           <![CDATA[ <210> 6853]]>
           <![CDATA[ <400> 6853]]>
          000
           <![CDATA[ <210> 6854]]>
           <![CDATA[ <400> 6854]]>
          000
           <![CDATA[ <210> 6855]]>
           <![CDATA[ <400> 6855]]>
          000
           <![CDATA[ <210> 6856]]>
           <![CDATA[ <400> 6856]]>
          000
           <![CDATA[ <210> 6857]]>
           <![CDATA[ <400> 6857]]>
          000
           <![CDATA[ <210> 6858]]>
           <![CDATA[ <400> 6858]]>
          000
           <![CDATA[ <210> 6859]]>
           <![CDATA[ <400> 6859]]>
          000
           <![CDATA[ <210> 6860]]>
           <![CDATA[ <400> 6860]]>
          000
           <![CDATA[ <210> 6861]]>
           <![CDATA[ <400> 6861]]>
          000
           <![CDATA[ <210> 6862]]>
           <![CDATA[ <400> 6862]]>
          000
           <![CDATA[ <210> 6863]]>
           <![CDATA[ <400> 6863]]>
          000
           <![CDATA[ <210> 6864]]>
           <![CDATA[ <400> 6864]]>
          000
           <![CDATA[ <210> 6865]]>
           <![CDATA[ <400> 6865]]>
          000
           <![CDATA[ <210> 6866]]>
           <![CDATA[ <400> 6866]]>
          000
           <![CDATA[ <210> 6867]]>
           <![CDATA[ <400> 6867]]>
          000
           <![CDATA[ <210> 6868]]>
           <![CDATA[ <400> 6868]]>
          000
           <![CDATA[ <210> 6869]]>
           <![CDATA[ <400> 6869]]>
          000
           <![CDATA[ <210> 6870]]>
           <![CDATA[ <400> 6870]]>
          000
           <![CDATA[ <210> 6871]]>
           <![CDATA[ <400> 6871]]>
          000
           <![CDATA[ <210> 6872]]>
           <![CDATA[ <400> 6872]]>
          000
           <![CDATA[ <210> 6873]]>
           <![CDATA[ <400> 6873]]>
          000
           <![CDATA[ <210> 6874]]>
           <![CDATA[ <400> 6874]]>
          000
           <![CDATA[ <210> 6875]]>
           <![CDATA[ <400> 6875]]>
          000
           <![CDATA[ <210> 6876]]>
           <![CDATA[ <400> 6876]]>
          000
           <![CDATA[ <210> 6877]]>
           <![CDATA[ <400> 6877]]>
          000
           <![CDATA[ <210> 6878]]>
           <![CDATA[ <400> 6878]]>
          000
           <![CDATA[ <210> 6879]]>
           <![CDATA[ <400> 6879]]>
          000
           <![CDATA[ <210> 6880]]>
           <![CDATA[ <400> 6880]]>
          000
           <![CDATA[ <210> 6881]]>
           <![CDATA[ <400> 6881]]>
          000
           <![CDATA[ <210> 6882]]>
           <![CDATA[ <400> 6882]]>
          000
           <![CDATA[ <210> 6883]]>
           <![CDATA[ <400> 6883]]>
          000
           <![CDATA[ <210> 6884]]>
           <![CDATA[ <400> 6884]]>
          000
           <![CDATA[ <210> 6885]]>
           <![CDATA[ <400> 6885]]>
          000
           <![CDATA[ <210> 6886]]>
           <![CDATA[ <400> 6886]]>
          000
           <![CDATA[ <210> 6887]]>
           <![CDATA[ <400> 6887]]>
          000
           <![CDATA[ <210> 6888]]>
           <![CDATA[ <400> 6888]]>
          000
           <![CDATA[ <210> 6889]]>
           <![CDATA[ <400> 6889]]>
          000
           <![CDATA[ <210> 6890]]>
           <![CDATA[ <400> 6890]]>
          000
           <![CDATA[ <210> 6891]]>
           <![CDATA[ <400> 6891]]>
          000
           <![CDATA[ <210> 6892]]>
           <![CDATA[ <400> 6892]]>
          000
           <![CDATA[ <210> 6893]]>
           <![CDATA[ <400> 6893]]>
          000
           <![CDATA[ <210> 6894]]>
           <![CDATA[ <400> 6894]]>
          000
           <![CDATA[ <210> 6895]]>
           <![CDATA[ <400> 6895]]>
          000
           <![CDATA[ <210> 6896]]>
           <![CDATA[ <400> 6896]]>
          000
           <![CDATA[ <210> 6897]]>
           <![CDATA[ <400> 6897]]>
          000
           <![CDATA[ <210> 6898]]>
           <![CDATA[ <400> 6898]]>
          000
           <![CDATA[ <210> 6899]]>
           <![CDATA[ <400> 6899]]>
          000
           <![CDATA[ <210> 6900]]>
           <![CDATA[ <400> 6900]]>
          000
           <![CDATA[ <210> 6901]]>
           <![CDATA[ <400> 6901]]>
          000
           <![CDATA[ <210> 6902]]>
           <![CDATA[ <400> 6902]]>
          000
           <![CDATA[ <210> 6903]]>
           <![CDATA[ <400> 6903]]>
          000
           <![CDATA[ <210> 6904]]>
           <![CDATA[ <400> 6904]]>
          000
           <![CDATA[ <210> 6905]]>
           <![CDATA[ <400> 6905]]>
          000
           <![CDATA[ <210> 6906]]>
           <![CDATA[ <400> 6906]]>
          000
           <![CDATA[ <210> 6907]]>
           <![CDATA[ <400> 6907]]>
          000
           <![CDATA[ <210> 6908]]>
           <![CDATA[ <400> 6908]]>
          000
           <![CDATA[ <210> 6909]]>
           <![CDATA[ <400> 6909]]>
          000
           <![CDATA[ <210> 6910]]>
           <![CDATA[ <400> 6910]]>
          000
           <![CDATA[ <210> 6911]]>
           <![CDATA[ <400> 6911]]>
          000
           <![CDATA[ <210> 6912]]>
           <![CDATA[ <400> 6912]]>
          000
           <![CDATA[ <210> 6913]]>
           <![CDATA[ <400> 6913]]>
          000
           <![CDATA[ <210> 6914]]>
           <![CDATA[ <400> 6914]]>
          000
           <![CDATA[ <210> 6915]]>
           <![CDATA[ <400> 6915]]>
          000
           <![CDATA[ <210> 6916]]>
           <![CDATA[ <400> 6916]]>
          000
           <![CDATA[ <210> 6917]]>
           <![CDATA[ <400> 6917]]>
          000
           <![CDATA[ <210> 6918]]>
           <![CDATA[ <400> 6918]]>
          000
           <![CDATA[ <210> 6919]]>
           <![CDATA[ <400> 6919]]>
          000
           <![CDATA[ <210> 6920]]>
           <![CDATA[ <400> 6920]]>
          000
           <![CDATA[ <210> 6921]]>
           <![CDATA[ <400> 6921]]>
          000
           <![CDATA[ <210> 6922]]>
           <![CDATA[ <400> 6922]]>
          000
           <![CDATA[ <210> 6923]]>
           <![CDATA[ <400> 6923]]>
          000
           <![CDATA[ <210> 6924]]>
           <![CDATA[ <400> 6924]]>
          000
           <![CDATA[ <210> 6925]]>
           <![CDATA[ <400> 6925]]>
          000
           <![CDATA[ <210> 6926]]>
           <![CDATA[ <400> 6926]]>
          000
           <![CDATA[ <210> 6927]]>
           <![CDATA[ <400> 6927]]>
          000
           <![CDATA[ <210> 6928]]>
           <![CDATA[ <400> 6928]]>
          000
           <![CDATA[ <210> 6929]]>
           <![CDATA[ <400> 6929]]>
          000
           <![CDATA[ <210> 6930]]>
           <![CDATA[ <400> 6930]]>
          000
           <![CDATA[ <210> 6931]]>
           <![CDATA[ <400> 6931]]>
          000
           <![CDATA[ <210> 6932]]>
           <![CDATA[ <400> 6932]]>
          000
           <![CDATA[ <210> 6933]]>
           <![CDATA[ <400> 6933]]>
          000
           <![CDATA[ <210> 6934]]>
           <![CDATA[ <400> 6934]]>
          000
           <![CDATA[ <210> 6935]]>
           <![CDATA[ <400> 6935]]>
          000
           <![CDATA[ <210> 6936]]>
           <![CDATA[ <400> 6936]]>
          000
           <![CDATA[ <210> 6937]]>
           <![CDATA[ <400> 6937]]>
          000
           <![CDATA[ <210> 6938]]>
           <![CDATA[ <400> 6938]]>
          000
           <![CDATA[ <210> 6939]]>
           <![CDATA[ <400> 6939]]>
          000
           <![CDATA[ <210> 6940]]>
           <![CDATA[ <400> 6940]]>
          000
           <![CDATA[ <210> 6941]]>
           <![CDATA[ <400> 6941]]>
          000
           <![CDATA[ <210> 6942]]>
           <![CDATA[ <400> 6942]]>
          000
           <![CDATA[ <210> 6943]]>
           <![CDATA[ <400> 6943]]>
          000
           <![CDATA[ <210> 6944]]>
           <![CDATA[ <400> 6944]]>
          000
           <![CDATA[ <210> 6945]]>
           <![CDATA[ <400> 6945]]>
          000
           <![CDATA[ <210> 6946]]>
           <![CDATA[ <400> 6946]]>
          000
           <![CDATA[ <210> 6947]]>
           <![CDATA[ <400> 6947]]>
          000
           <![CDATA[ <210> 6948]]>
           <![CDATA[ <400> 6948]]>
          000
           <![CDATA[ <210> 6949]]>
           <![CDATA[ <400> 6949]]>
          000
           <![CDATA[ <210> 6950]]>
           <![CDATA[ <400> 6950]]>
          000
           <![CDATA[ <210> 6951]]>
           <![CDATA[ <400> 6951]]>
          000
           <![CDATA[ <210> 6952]]>
           <![CDATA[ <400> 6952]]>
          000
           <![CDATA[ <210> 6953]]>
           <![CDATA[ <400> 6953]]>
          000
           <![CDATA[ <210> 6954]]>
           <![CDATA[ <400> 6954]]>
          000
           <![CDATA[ <210> 6955]]>
           <![CDATA[ <400> 6955]]>
          000
           <![CDATA[ <210> 6956]]>
           <![CDATA[ <400> 6956]]>
          000
           <![CDATA[ <210> 6957]]>
           <![CDATA[ <400> 6957]]>
          000
           <![CDATA[ <210> 6958]]>
           <![CDATA[ <400> 6958]]>
          000
           <![CDATA[ <210> 6959]]>
           <![CDATA[ <400> 6959]]>
          000
           <![CDATA[ <210> 6960]]>
           <![CDATA[ <400> 6960]]>
          000
           <![CDATA[ <210> 6961]]>
           <![CDATA[ <400> 6961]]>
          000
           <![CDATA[ <210> 6962]]>
           <![CDATA[ <400> 6962]]>
          000
           <![CDATA[ <210> 6963]]>
           <![CDATA[ <400> 6963]]>
          000
           <![CDATA[ <210> 6964]]>
           <![CDATA[ <400> 6964]]>
          000
           <![CDATA[ <210> 6965]]>
           <![CDATA[ <400> 6965]]>
          000
           <![CDATA[ <210> 6966]]>
           <![CDATA[ <400> 6966]]>
          000
           <![CDATA[ <210> 6967]]>
           <![CDATA[ <400> 6967]]>
          000
           <![CDATA[ <210> 6968]]>
           <![CDATA[ <400> 6968]]>
          000
           <![CDATA[ <210> 6969]]>
           <![CDATA[ <400> 6969]]>
          000
           <![CDATA[ <210> 6970]]>
           <![CDATA[ <400> 6970]]>
          000
           <![CDATA[ <210> 6971]]>
           <![CDATA[ <400> 6971]]>
          000
           <![CDATA[ <210> 6972]]>
           <![CDATA[ <400> 6972]]>
          000
           <![CDATA[ <210> 6973]]>
           <![CDATA[ <400> 6973]]>
          000
           <![CDATA[ <210> 6974]]>
           <![CDATA[ <400> 6974]]>
          000
           <![CDATA[ <210> 6975]]>
           <![CDATA[ <400> 6975]]>
          000
           <![CDATA[ <210> 6976]]>
           <![CDATA[ <400> 6976]]>
          000
           <![CDATA[ <210> 6977]]>
           <![CDATA[ <400> 6977]]>
          000
           <![CDATA[ <210> 6978]]>
           <![CDATA[ <400> 6978]]>
          000
           <![CDATA[ <210> 6979]]>
           <![CDATA[ <400> 6979]]>
          000
           <![CDATA[ <210> 6980]]>
           <![CDATA[ <400> 6980]]>
          000
           <![CDATA[ <210> 6981]]>
           <![CDATA[ <400> 6981]]>
          000
           <![CDATA[ <210> 6982]]>
           <![CDATA[ <400> 6982]]>
          000
           <![CDATA[ <210> 6983]]>
           <![CDATA[ <400> 6983]]>
          000
           <![CDATA[ <210> 6984]]>
           <![CDATA[ <400> 6984]]>
          000
           <![CDATA[ <210> 6985]]>
           <![CDATA[ <400> 6985]]>
          000
           <![CDATA[ <210> 6986]]>
           <![CDATA[ <400> 6986]]>
          000
           <![CDATA[ <210> 6987]]>
           <![CDATA[ <400> 6987]]>
          000
           <![CDATA[ <210> 6988]]>
           <![CDATA[ <400> 6988]]>
          000
           <![CDATA[ <210> 6989]]>
           <![CDATA[ <400> 6989]]>
          000
           <![CDATA[ <210> 6990]]>
           <![CDATA[ <400> 6990]]>
          000
           <![CDATA[ <210> 6991]]>
           <![CDATA[ <400> 6991]]>
          000
           <![CDATA[ <210> 6992]]>
           <![CDATA[ <400> 6992]]>
          000
           <![CDATA[ <210> 6993]]>
           <![CDATA[ <400> 6993]]>
          000
           <![CDATA[ <210> 6994]]>
           <![CDATA[ <400> 6994]]>
          000
           <![CDATA[ <210> 6995]]>
           <![CDATA[ <400> 6995]]>
          000
           <![CDATA[ <210> 6996]]>
           <![CDATA[ <400> 6996]]>
          000
           <![CDATA[ <210> 6997]]>
           <![CDATA[ <400> 6997]]>
          000
           <![CDATA[ <210> 6998]]>
           <![CDATA[ <400> 6998]]>
          000
           <![CDATA[ <210> 6999]]>
           <![CDATA[ <400> 6999]]>
          000
           <![CDATA[ <210> 7000]]>
           <![CDATA[ <400> 7000]]>
          000
           <![CDATA[ <210> 7001]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7001]]>
          Glu Ala Gly Arg Ser Ala Asn His Glu Pro Leu Gly Leu Val Ala Thr
          1 5 10 15
           <![CDATA[ <210> 7002]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7002]]>
          Ala Ser Gly Arg Ser Thr Asn Ala Gly Pro Ser Gly Leu Ala Gly Pro
          1 5 10 15
           <![CDATA[ <210> 7003]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7003]]>
          Ala Ser Gly Arg Ser Thr Asn Ala Gly Pro Gln Gly Leu Ala Gly Gln
          1 5 10 15
           <![CDATA[ <210> 7004]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7004]]>
          Ala Ser Gly Arg Ser Thr Asn Ala Gly Pro Pro Gly Leu Thr Gly Pro
          1 5 10 15
           <![CDATA[ <210> 7005]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7005]]>
          Ala Ser Ser Arg Gly Thr Asn Ala Gly Pro Ala Gly Leu Thr Gly Pro
          1 5 10 15
           <![CDATA[ <210> 7006]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7006]]>
          Ala Ser Ser Arg Thr Thr Asn Thr Gly Pro Ser Thr Leu Thr Gly Pro
          1 5 10 15
           <![CDATA[ <210> 7007]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7007]]>
          Ala Ala Gly Arg Ser Asp Asn Gly Thr Pro Leu Glu Leu Val Ala Pro
          1 5 10 15
           <![CDATA[ <210> 7008]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7008]]>
          Glu Ala Gly Arg Ser Ala Asn His Glu Pro Leu Gly Leu Val Ala Thr
          1 5 10 15
           <![CDATA[ <210> 7009]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7009]]>
          Ala Ser Gly Arg Gly Thr Asn Ala Gly Pro Ala Gly Leu Thr Gly Pro
          1 5 10 15
           <![CDATA[ <210> 7010]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7010]]>
          Leu Phe Gly Arg Asn Asp Asn His Glu Pro Leu Glu Leu Gly Gly Gly
          1 5 10 15
           <![CDATA[ <210> 7011]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7011]]>
          Thr Ala Gly Arg Ser Asp Asn Leu Glu Pro Leu Gly Leu Val Phe Gly
          1 5 10 15
           <![CDATA[ <210> 7012]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7012]]>
          Leu Asp Gly Arg Ser Asp Asn Phe His Pro Pro Glu Leu Val Ala Gly
          1 5 10 15
           <![CDATA[ <210> 7013]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7013]]>
          Leu Glu Gly Arg Ser Asp Asn Glu Glu Pro Glu Asn Leu Val Ala Gly
          1 5 10 15
           <![CDATA[ <210> 7014]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7014]]>
          Leu Lys Gly Arg Ser Asp Asn Asn Ala Pro Leu Ala Leu Val Ala Gly
          1 5 10 15
           <![CDATA[ <210> 7015]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7015]]>
          Val Tyr Ser Arg Gly Thr Asn Ala Gly Pro His Gly Leu Thr Gly Arg
          1 5 10 15
           <![CDATA[ <210> 7016]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7016]]>
          Ala Asn Ser Arg Gly Thr Asn Lys Gly Phe Ala Gly Leu Ile Gly Pro
          1 5 10 15
           <![CDATA[ <210> 7017]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7017]]>
          Ala Ser Ser Arg Leu Thr Asn Glu Ala Pro Ala Gly Leu Thr Ile Pro
          1 5 10 15
           <![CDATA[ <210> 7018]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7018]]>
          Asp Gln Ser Arg Gly Thr Asn Ala Gly Pro Glu Gly Leu Thr Asp Pro
          1 5 10 15
           <![CDATA[ <210> 7019]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7019]]>
          Glu Ser Ser Arg Gly Thr Asn Ile Gly Gln Gly Gly Leu Thr Gly Pro
          1 5 10 15
           <![CDATA[ <210> 7020]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7020]]>
          Ser Ser Ser Arg Gly Thr Asn Gln Asp Pro Ala Gly Leu Thr Ile Pro
          1 5 10 15
           <![CDATA[ <210> 7021]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7021]]>
          Ala Ser Ser Arg Gly Gln Asn His Ser Pro Met Gly Leu Thr Gly Pro
          1 5 10 15
           <![CDATA[ <210> 7022]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7022]]>
          Ala Tyr Ser Arg Gly Pro Asn Ala Gly Pro Ala Gly Leu Glu Gly Arg
          1 5 10 15
           <![CDATA[ <210> 7023]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7023]]>
          Ala Ser Glu Arg Gly Asn Asn Ala Gly Pro Ala Asn Leu Thr Gly Phe
          1 5 10 15
           <![CDATA[ <210> 7024]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7024]]>
          Ala Ser His Arg Gly Thr Asn Pro Lys Pro Ala Ile Leu Thr Gly Pro
          1 5 10 15
           <![CDATA[ <210> 7025]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7025]]>
          Met Ser Ser Arg Arg Thr Asn Ala Asn Pro Ala Gln Leu Thr Gly Pro
          1 5 10 15
           <![CDATA[ <210> 7026]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7026]]>
          Gly Ala Gly Arg Thr Asp Asn His Glu Pro Leu Glu Leu Gly Ala Ala
          1 5 10 15
           <![CDATA[ <210> 7027]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7027]]>
          Leu Ala Gly Arg Ser Glu Asn Thr Ala Pro Leu Glu Leu Thr Ala Gly
          1 5 10 15
           <![CDATA[ <210> 7028]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7028]]>
          Leu Glu Gly Arg Pro Asp Asn His Glu Pro Leu Ala Leu Val Ala Ser
          1 5 10 15
           <![CDATA[ <210> 7029]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7029]]>
          Leu Ser Gly Arg Ser Asp Asn Glu Glu Pro Leu Ala Leu Pro Ala Gly
          1 5 10 15
           <![CDATA[ <210> 7030]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7030]]>
          Glu Ala Gly Arg Thr Asp Asn His Glu Pro Leu Glu Leu Ser Ala Pro
          1 5 10 15
           <![CDATA[ <210> 7031]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7031]]>
          Glu Gly Gly Arg Ser Asp Asn His Gly Pro Leu Glu Leu Val Ser Gly
          1 5 10 15
           <![CDATA[ <210> 7032]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7032]]>
          Leu Ser Gly Arg Ser Asp Asn Glu Ala Pro Leu Glu Leu Glu Ala Gly
          1 5 10 15
           <![CDATA[ <210> 7033]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7033]]>
          Leu Gly Gly Arg Ala Asp Asn His Glu Pro Pro Glu Leu Gly Ala Gly
          1 5 10 15
           <![CDATA[ <210> 7034]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7034]]>
          Pro Pro Ser Arg Gly Thr Asn Ala Glu Pro Ala Gly Leu Thr Gly Glu
          1 5 10 15
           <![CDATA[ <210> 7035]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7035]]>
          Ala Ser Thr Arg Gly Glu Asn Ala Gly Pro Ala Gly Leu Glu Ala Pro
          1 5 10 15
           <![CDATA[ <210> 7036]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7036]]>
          Glu Ser Ser Arg Gly Thr Asn Gly Ala Pro Glu Gly Leu Thr Gly Pro
          1 5 10 15
           <![CDATA[ <210> 7037]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7037]]>
          Ala Ser Ser Arg Ala Thr Asn Glu Ser Pro Ala Gly Leu Thr Gly Glu
          1 5 10 15
           <![CDATA[ <210> 7038]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7038]]>
          Ala Ser Ser Arg Gly Glu Asn Pro Pro Pro Gly Gly Leu Thr Gly Pro
          1 5 10 15
           <![CDATA[ <210> 7039]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7039]]>
          Ala Ala Ser Arg Gly Thr Asn Thr Gly Pro Ala Glu Leu Thr Gly Ser
          1 5 10 15
           <![CDATA[ <210> 7040]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7040]]>
          Ala Gly Ser Arg Thr Thr Asn Ala Gly Pro Gly Gly Leu Glu Gly Pro
          1 5 10 15
           <![CDATA[ <210> 7041]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7041]]>
          Ala Pro Ser Arg Gly Glu Asn Ala Gly Pro Ala Thr Leu Thr Gly Ala
          1 5 10 15
           <![CDATA[ <210> 7042]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7042]]>
          Glu Ser Gly Arg Ala Ala Asn Thr Gly Pro Pro Thr Leu Thr Ala Pro
          1 5 10 15
           <![CDATA[ <210> 7043]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7043]]>
          Asn Pro Gly Arg Ala Ala Asn Glu Gly Pro Pro Gly Leu Pro Gly Ser
          1 5 10 15
           <![CDATA[ <210> 7044]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7044]]>
          Glu Ser Ser Arg Ala Ala Asn Leu Thr Pro Pro Glu Leu Thr Gly Pro
          1 5 10 15
           <![CDATA[ <210> 7045]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7045]]>
          Ala Ser Gly Arg Ala Ala Asn Glu Thr Pro Pro Gly Leu Thr Gly Ala
          1 5 10 15
           <![CDATA[ <210> 7046]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7046]]>
          Asn Ser Gly Arg Gly Glu Asn Leu Gly Ala Pro Gly Leu Thr Gly Thr
          1 5 10 15
           <![CDATA[ <210> 7047]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7047]]>
          Thr Thr Gly Arg Ala Ala Asn Leu Thr Pro Ala Gly Leu Thr Gly Pro
          1 5 10 15
           <![CDATA[ <210> 7048]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7048]]>
          Glu Ala Gly Arg Ser Ala Asn His Thr Pro Ala Gly Leu Thr Gly Pro
          1 5 10 15
           <![CDATA[ <210> 7049]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7049]]>
          Glu Ser Gly Arg Ala Ala Asn Thr Thr Pro Ala Gly Leu Thr Gly Pro
          1 5 10 15
           <![CDATA[ <210> 7050]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7050]]>
          Thr Thr Gly Arg Ala Thr Glu Ala Ala Asn Leu Thr Pro Ala Gly Leu
          1 5 10 15
          Thr Gly Pro
           <![CDATA[ <210> 7051]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7051]]>
          Thr Thr Gly Arg Ala Glu Glu Ala Ala Asn Leu Thr Pro Ala Gly Leu
          1 5 10 15
          Thr Gly Pro
           <![CDATA[ <210> 7052]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7052]]>
          Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr Pro Ala Gly Leu
          1 5 10 15
          Thr Gly Pro
           <![CDATA[ <210> 7053]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7053]]>
          Thr Thr Gly Arg Ala Thr Glu Ala Ala Asn Ala Thr Pro Ala Gly Leu
          1 5 10 15
          Thr Gly Pro
           <![CDATA[ <210> 7054]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7054]]>
          Thr Thr Gly Arg Ala Gly Glu Ala Glu Gly Ala Thr Ser Ala Gly Ala
          1 5 10 15
          Thr Gly Pro
           <![CDATA[ <210> 7055]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7055]]>
          Thr Thr Gly Glu Ala Gly Glu Ala Ala Asn Ala Thr Ser Ala Gly Ala
          1 5 10 15
          Thr Gly Pro
           <![CDATA[ <210> 7056]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7056]]>
          Thr Thr Gly Glu Ala Gly Glu Ala Ala Gly Leu Thr Pro Ala Gly Leu
          1 5 10 15
          Thr Gly Pro
           <![CDATA[ <210> 7057]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7057]]>
          Thr Thr Gly Ala Ala Gly Glu Ala Ala Asn Ala Thr Pro Ala Gly Leu
          1 5 10 15
          Thr Gly Pro
           <![CDATA[ <210> 7058]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7058]]>
          Thr Thr Gly Arg Ala Gly Glu Ala Ala Gly Leu Thr Pro Ala Gly Leu
          1 5 10 15
          Thr Gly Pro
           <![CDATA[ <210> 7059]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7059]]>
          Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Ala Thr Ser Ala Gly Ala
          1 5 10 15
          Thr Gly Pro
           <![CDATA[ <210> 7060]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7060]]>
          Thr Thr Gly Glu Ala Gly Glu Ala Ala Gly Ala Thr Ser Ala Gly Ala
          1 5 10 15
          Thr Gly Pro
           <![CDATA[ <210> 7061]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7061]]>
          Glu Ser Gly Arg Ala Ala Asn Thr Glu Pro Pro Glu Leu Gly Ala Gly
          1 5 10 15
           <![CDATA[ <210> 7062]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7062]]>
          Glu Ser Gly Arg Ala Ala Asn Thr Ala Pro Glu Gly Leu Thr Gly Pro
          1 5 10 15
           <![CDATA[ <210> 7063]]>
           <![CDATA[ <211> 16]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7063]]>
          Glu Pro Gly Arg Ala Ala Asn His Glu Pro Ser Gly Leu Thr Glu Gly
          1 5 10 15
           <![CDATA[ <210> 7064]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7064]]>
          Glu Ser Gly Arg Ala Ala Asn His Thr Gly Ala Pro Pro Gly Gly Leu
          1 5 10 15
          Thr Gly Pro
           <![CDATA[ <210> 7065]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7065]]>
          Thr Thr Gly Arg Thr Gly Glu Gly Ala Asn Ala Thr Pro Gly Gly Leu
          1 5 10 15
          Thr Gly Pro
           <![CDATA[ <210> 7066]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7066]]>
          Arg Thr Gly Arg Ser Gly Glu Ala Ala Asn Glu Thr Pro Glu Gly Leu
          1 5 10 15
          Glu Gly Pro
           <![CDATA[ <210> 7067]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7067]]>
          Arg Thr Gly Arg Thr Gly Glu Ser Ala Asn Glu Thr Pro Ala Gly Leu
          1 5 10 15
          Gly Gly Pro
           <![CDATA[ <210> 7068]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7068]]>
          Ser Thr Gly Arg Thr Gly Glu Pro Ala Asn Glu Thr Pro Ala Gly Leu
          1 5 10 15
          Ser Gly Pro
           <![CDATA[ <210> 7069]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7069]]>
          Thr Thr Gly Arg Ala Gly Glu Pro Ala Asn Ala Thr Pro Thr Gly Leu
          1 5 10 15
          Ser Gly Pro
           <![CDATA[ <210> 7070]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7070]]>
          Arg Thr Gly Arg Pro Gly Glu Gly Ala Asn Ala Thr Pro Thr Gly Leu
          1 5 10 15
          Pro Gly Pro
           <![CDATA[ <210> 7071]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7071]]>
          Arg Thr Gly Arg Gly Gly Glu Ala Ala Asn Ala Thr Pro Ser Gly Leu
          1 5 10 15
          Gly Gly Pro
           <![CDATA[ <210> 7072]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7072]]>
          Ser Thr Gly Arg Ser Gly Glu Ser Ala Asn Ala Thr Pro Gly Gly Leu
          1 5 10 15
          Gly Gly Pro
           <![CDATA[ <210> 7073]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7073]]>
          Arg Thr Gly Arg Thr Gly Glu Glu Ala Asn Ala Thr Pro Ala Gly Leu
          1 5 10 15
          Pro Gly Pro
           <![CDATA[ <210> 7074]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7074]]>
          Ala Thr Gly Arg Pro Gly Glu Pro Ala Asn Thr Thr Pro Glu Gly Leu
          1 5 10 15
          Glu Gly Pro
           <![CDATA[ <210> 7075]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7075]]>
          Ser Thr Gly Arg Ser Gly Glu Pro Ala Asn Ala Thr Pro Gly Gly Leu
          1 5 10 15
          Thr Gly Pro
           <![CDATA[ <210> 7076]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7076]]>
          Pro Thr Gly Arg Gly Gly Glu Gly Ala Asn Thr Thr Pro Thr Gly Leu
          1 5 10 15
          Pro Gly Pro
           <![CDATA[ <210> 7077]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7077]]>
          Pro Thr Gly Arg Ser Gly Glu Gly Ala Asn Ala Thr Pro Ser Gly Leu
          1 5 10 15
          Thr Gly Pro
           <![CDATA[ <210> 7078]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7078]]>
          Thr Thr Gly Arg Ala Ser Glu Gly Ala Asn Ser Thr Pro Ala Pro Leu
          1 5 10 15
          Thr Glu Pro
           <![CDATA[ <210> 7079]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7079]]>
          Thr Tyr Gly Arg Ala Ala Glu Ala Ala Asn Thr Thr Pro Ala Gly Leu
          1 5 10 15
          Thr Ala Pro
           <![CDATA[ <210> 7080]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7080]]>
          Thr Thr Gly Arg Ala Thr Glu Gly Ala Asn Ala Thr Pro Ala Glu Leu
          1 5 10 15
          Thr Glu Pro
           <![CDATA[ <210> 7081]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7081]]>
          Thr Val Gly Arg Ala Ser Glu Glu Ala Asn Thr Thr Pro Ala Ser Leu
          1 5 10 15
          Thr Gly Pro
           <![CDATA[ <210> 7082]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7082]]>
          Thr Thr Gly Arg Ala Pro Glu Ala Ala Asn Ala Thr Pro Ala Pro Leu
          1 5 10 15
          Thr Gly Pro
           <![CDATA[ <210> 7083]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7083]]>
          Thr Trp Gly Arg Ala Thr Glu Pro Ala Asn Ala Thr Pro Ala Pro Leu
          1 5 10 15
          Thr Ser Pro
           <![CDATA[ <210> 7084]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7084]]>
          Thr Val Gly Arg Ala Ser Glu Ser Ala Asn Ala Thr Pro Ala Glu Leu
          1 5 10 15
          Thr Ser Pro
           <![CDATA[ <210> 7085]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7085]]>
          Thr Val Gly Arg Ala Pro Glu Gly Ala Asn Ser Thr Pro Ala Gly Leu
          1 5 10 15
          Thr Gly Pro
           <![CDATA[ <210> 7086]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7086]]>
          Thr Trp Gly Arg Ala Thr Glu Ala Pro Asn Leu Glu Pro Ala Thr Leu
          1 5 10 15
          Thr Thr Pro
           <![CDATA[ <210> 7087]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7087]]>
          Thr Thr Gly Arg Ala Thr Glu Ala Pro Asn Leu Thr Pro Ala Pro Leu
          1 5 10 15
          Thr Glu Pro
           <![CDATA[ <210> 7088]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7088]]>
          Thr Gln Gly Arg Ala Thr Glu Ala Pro Asn Leu Ser Pro Ala Ala Leu
          1 5 10 15
          Thr Ser Pro
           <![CDATA[ <210> 7089]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7089]]>
          Thr Gln Gly Arg Ala Ala Glu Ala Pro Asn Leu Thr Pro Ala Thr Leu
          1 5 10 15
          Thr Ala Pro
           <![CDATA[ <210> 7090]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7090]]>
          Thr Ser Gly Arg Ala Pro Glu Ala Thr Asn Leu Ala Pro Ala Pro Leu
          1 5 10 15
          Thr Gly Pro
           <![CDATA[ <210> 7091]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7091]]>
          Thr Gln Gly Arg Ala Ala Glu Ala Ala Asn Leu Thr Pro Ala Gly Leu
          1 5 10 15
          Thr Glu Pro
           <![CDATA[ <210> 7092]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7092]]>
          Thr Thr Gly Arg Ala Gly Ser Ala Pro Asn Leu Pro Pro Thr Gly Leu
          1 5 10 15
          Thr Thr Pro
           <![CDATA[ <210> 7093]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7093]]>
          Thr Thr Gly Arg Ala Gly Gly Ala Glu Asn Leu Pro Pro Glu Gly Leu
          1 5 10 15
          Thr Ala Pro
           <![CDATA[ <210> 7094]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7094]]>
          Thr Thr Ser Arg Ala Gly Thr Ala Thr Asn Leu Thr Pro Glu Gly Leu
          1 5 10 15
          Thr Ala Pro
           <![CDATA[ <210> 7095]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7095]]>
          Thr Thr Gly Arg Ala Gly Thr Ala Thr Asn Leu Pro Pro Ser Gly Leu
          1 5 10 15
          Thr Thr Pro
           <![CDATA[ <210> 7096]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7096]]>
          Thr Thr Ala Arg Ala Gly Glu Ala Glu Asn Leu Ser Pro Ser Gly Leu
          1 5 10 15
          Thr Ala Pro
           <![CDATA[ <210> 7097]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7097]]>
          Thr Thr Gly Arg Ala Gly Gly Ala Gly Asn Leu Ala Pro Gly Gly Leu
          1 5 10 15
          Thr Glu Pro
           <![CDATA[ <210> 7098]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7098]]>
          Thr Thr Gly Arg Ala Gly Thr Ala Thr Asn Leu Pro Pro Glu Gly Leu
          1 5 10 15
          Thr Gly Pro
           <![CDATA[ <210> 7099]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7099]]>
          Thr Thr Gly Arg Ala Gly Gly Ala Ala Asn Leu Ala Pro Thr Gly Leu
          1 5 10 15
          Thr Glu Pro
           <![CDATA[ <210> 7100]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7100]]>
          Thr Thr Gly Arg Ala Gly Thr Ala Glu Asn Leu Ala Pro Ser Gly Leu
          1 5 10 15
          Thr Thr Pro
           <![CDATA[ <210> 7101]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7101]]>
          Thr Thr Gly Arg Ala Gly Ser Ala Thr Asn Leu Gly Pro Gly Gly Leu
          1 5 10 15
          Thr Gly Pro
           <![CDATA[ <210> 7102]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7102]]>
          Thr Thr Ala Arg Ala Gly Gly Ala Glu Asn Leu Thr Pro Ala Gly Leu
          1 5 10 15
          Thr Glu Pro
           <![CDATA[ <210> 7103]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7103]]>
          Thr Thr Ala Arg Ala Gly Ser Ala Glu Asn Leu Ser Pro Ser Gly Leu
          1 5 10 15
          Thr Gly Pro
           <![CDATA[ <210> 7104]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7104]]>
          Thr Thr Ala Arg Ala Gly Gly Ala Gly Asn Leu Ala Pro Glu Gly Leu
          1 5 10 15
          Thr Thr Pro
           <![CDATA[ <210> 7105]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7105]]>
          Thr Thr Ser Arg Ala Gly Ala Ala Glu Asn Leu Thr Pro Thr Gly Leu
          1 5 10 15
          Thr Gly Pro
           <![CDATA[ <210> 7106]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7106]]>
          Thr Tyr Gly Arg Thr Thr Thr Pro Gly Asn Glu Pro Pro Ala Ser Leu
          1 5 10 15
          Glu Ala Glu
           <![CDATA[ <210> 7107]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7107]]>
          Thr Tyr Ser Arg Gly Glu Ser Gly Pro Asn Glu Pro Pro Pro Gly Leu
          1 5 10 15
          Thr Gly Pro
           <![CDATA[ <210> 7108]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7108]]>
          Ala Trp Gly Arg Thr Gly Ala Ser Glu Asn Glu Thr Pro Ala Pro Leu
          1 5 10 15
          Gly Gly Glu
           <![CDATA[ <210> 7109]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7109]]>
          Arg Trp Gly Arg Ala Glu Thr Thr Pro Asn Thr Pro Pro Glu Gly Leu
          1 5 10 15
          Glu Thr Glu
           <![CDATA[ <210> 7110]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7110]]>
          Glu Ser Gly Arg Ala Ala Asn His Thr Gly Ala Glu Pro Pro Glu Leu
          1 5 10 15
          Gly Ala Gly
           <![CDATA[ <210> 7111]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7111]]>
          Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr Pro Ala Gly Leu
          1 5 10 15
          Thr Glu Ser
           <![CDATA[ <210> 7112]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7112]]>
          Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr Pro Ala Ala Leu
          1 5 10 15
          Thr Glu Ser
           <![CDATA[ <210> 7113]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7113]]>
          Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr Pro Ala Pro Leu
          1 5 10 15
          Thr Glu Ser
           <![CDATA[ <210> 7114]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7114]]>
          Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr Pro Glu Pro Leu
          1 5 10 15
          Thr Glu Ser
           <![CDATA[ <210> 7115]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7115]]>
          Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr Pro Ala Gly Leu
          1 5 10 15
          Thr Gly Ala
           <![CDATA[ <210> 7116]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7116]]>
          Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr Pro Glu Gly Leu
          1 5 10 15
          Thr Gly Ala
           <![CDATA[ <210> 7117]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7117]]>
          Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr Pro Glu Pro Leu
          1 5 10 15
          Thr Gly Ala
           <![CDATA[ <210> 7118]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7118]]>
          Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr Pro Ala Gly Leu
          1 5 10 15
          Thr Glu Ala
           <![CDATA[ <210> 7119]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7119]]>
          Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr Pro Glu Gly Leu
          1 5 10 15
          Thr Glu Ala
           <![CDATA[ <210> 7120]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7120]]>
          Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr Pro Ala Pro Leu
          1 5 10 15
          Thr Glu Ala
           <![CDATA[ <210> 7121]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7121]]>
          Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr Pro Glu Pro Leu
          1 5 10 15
          Thr Glu Ala
           <![CDATA[ <210> 7122]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7122]]>
          Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr Pro Glu Pro Leu
          1 5 10 15
          Thr Gly Pro
           <![CDATA[ <210> 7123]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7123]]>
          Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr Pro Ala Gly Leu
          1 5 10 15
          Thr Gly Gly
           <![CDATA[ <210> 7124]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7124]]>
          Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr Pro Glu Gly Leu
          1 5 10 15
          Thr Gly Gly
           <![CDATA[ <210> 7125]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7125]]>
          Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr Pro Glu Ala Leu
          1 5 10 15
          Thr Gly Gly
           <![CDATA[ <210> 7126]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7126]]>
          Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr Pro Glu Pro Leu
          1 5 10 15
          Thr Gly Gly
           <![CDATA[ <210> 7127]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7127]]>
          Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr Pro Ala Gly Leu
          1 5 10 15
          Thr Glu Gly
           <![CDATA[ <210> 7128]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7128]]>
          Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr Pro Glu Gly Leu
          1 5 10 15
          Thr Glu Gly
           <![CDATA[ <210> 7129]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7129]]>
          Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr Pro Ala Pro Leu
          1 5 10 15
          Thr Glu Gly
           <![CDATA[ <210> 7130]]>
           <![CDATA[ <211> 19]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7130]]>
          Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr Pro Glu Pro Leu
          1 5 10 15
          Thr Glu Gly
           <![CDATA[ <210> 7131]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7131]]>
          Gly Ser Ala Pro Gly Ser Ala Gly Gly Tyr Ala Glu Leu Arg Met Gly
          1 5 10 15
          Gly Ala Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7132]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7132]]>
          Gly Ser Ala Pro Gly Thr Gly Gly Gly Tyr Ala Pro Leu Arg Met Gly
          1 5 10 15
          Gly Gly Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7133]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7133]]>
          Gly Ser Ala Pro Gly Ala Glu Gly Gly Tyr Ala Ala Leu Arg Met Gly
          1 5 10 15
          Gly Glu Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7134]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7134]]>
          Gly Ser Ala Pro Gly Gly Pro Gly Gly Tyr Ala Leu Leu Arg Met Gly
          1 5 10 15
          Gly Pro Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7135]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7135]]>
          Gly Ser Ala Pro Gly Glu Ala Gly Gly Tyr Ala Phe Leu Arg Met Gly
          1 5 10 15
          Gly Ser Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7136]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7136]]>
          Gly Ser Ala Pro Gly Pro Gly Gly Gly Tyr Ala Ser Leu Arg Met Gly
          1 5 10 15
          Gly Thr Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7137]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7137]]>
          Gly Ser Ala Pro Gly Ser Glu Gly Gly Tyr Ala Thr Leu Arg Met Gly
          1 5 10 15
          Gly Ala Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7138]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7138]]>
          Gly Ser Ala Pro Gly Thr Pro Gly Gly Tyr Ala Asn Leu Arg Met Gly
          1 5 10 15
          Gly Gly Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7139]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7139]]>
          Gly Ser Ala Pro Gly Ala Ser Gly Gly Tyr Ala His Leu Arg Met Gly
          1 5 10 15
          Gly Glu Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7140]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7140]]>
          Gly Ser Ala Pro Gly Gly Thr Gly Gly Tyr Gly Glu Leu Arg Met Gly
          1 5 10 15
          Gly Pro Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7141]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7141]]>
          Gly Ser Ala Pro Gly Glu Ala Gly Gly Tyr Pro Glu Leu Arg Met Gly
          1 5 10 15
          Gly Ser Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7142]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7142]]>
          Gly Ser Ala Pro Gly Pro Gly Gly Gly Tyr Val Glu Leu Arg Met Gly
          1 5 10 15
          Gly Thr Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7143]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7143]]>
          Gly Ser Ala Pro Gly Ser Glu Gly Gly Tyr Leu Glu Leu Arg Met Gly
          1 5 10 15
          Gly Ala Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7144]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7144]]>
          Gly Ser Ala Pro Gly Thr Pro Gly Gly Tyr Ser Glu Leu Arg Met Gly
          1 5 10 15
          Gly Gly Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7145]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7145]]>
          Gly Ser Ala Pro Gly Ala Ser Gly Gly Tyr Thr Glu Leu Arg Met Gly
          1 5 10 15
          Gly Glu Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7146]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7146]]>
          Gly Ser Ala Pro Gly Gly Thr Gly Gly Tyr Gln Glu Leu Arg Met Gly
          1 5 10 15
          Gly Pro Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7147]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7147]]>
          Gly Ser Ala Pro Gly Glu Ala Gly Gly Tyr Glu Glu Leu Arg Met Gly
          1 5 10 15
          Gly Ser Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7148]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7148]]>
          Gly Ser Ala Pro Gly Pro Gly Ile Gly Pro Ala Glu Leu Arg Met Gly
          1 5 10 15
          Gly Thr Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7149]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7149]]>
          Gly Ser Ala Pro Gly Ser Glu Ile Gly Ala Ala Glu Leu Arg Met Gly
          1 5 10 15
          Gly Ala Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7150]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7150]]>
          Gly Ser Ala Pro Gly Thr Pro Ile Gly Ser Ala Glu Leu Arg Met Gly
          1 5 10 15
          Gly Gly Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7151]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7151]]>
          Gly Ser Ala Pro Gly Ala Ser Ile Gly Thr Ala Glu Leu Arg Met Gly
          1 5 10 15
          Gly Glu Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7152]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7152]]>
          Gly Ser Ala Pro Gly Gly Thr Ile Gly Asn Ala Glu Leu Arg Met Gly
          1 5 10 15
          Gly Pro Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7153]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7153]]>
          Gly Ser Ala Pro Gly Glu Ala Ile Gly Gln Ala Glu Leu Arg Met Gly
          1 5 10 15
          Gly Ser Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7154]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7154]]>
          Gly Ser Ala Pro Gly Pro Gly Gly Pro Tyr Ala Glu Leu Arg Met Gly
          1 5 10 15
          Gly Thr Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7155]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7155]]>
          Gly Ser Ala Pro Gly Ser Glu Gly Ala Tyr Ala Glu Leu Arg Met Gly
          1 5 10 15
          Gly Ala Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7156]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7156]]>
          Gly Ser Ala Pro Gly Thr Pro Gly Val Tyr Ala Glu Leu Arg Met Gly
          1 5 10 15
          Gly Gly Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7157]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7157]]>
          Gly Ser Ala Pro Gly Ala Ser Gly Leu Tyr Ala Glu Leu Arg Met Gly
          1 5 10 15
          Gly Glu Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7158]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7158]]>
          Gly Ser Ala Pro Gly Gly Thr Gly Ile Tyr Ala Glu Leu Arg Met Gly
          1 5 10 15
          Gly Pro Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7159]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7159]]>
          Gly Ser Ala Pro Gly Glu Ala Gly Phe Tyr Ala Glu Leu Arg Met Gly
          1 5 10 15
          Gly Ser Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7160]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7160]]>
          Gly Ser Ala Pro Gly Pro Gly Gly Tyr Tyr Ala Glu Leu Arg Met Gly
          1 5 10 15
          Gly Thr Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7161]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7161]]>
          Gly Ser Ala Pro Gly Ser Glu Gly Ser Tyr Ala Glu Leu Arg Met Gly
          1 5 10 15
          Gly Ala Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7162]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7162]]>
          Gly Ser Ala Pro Gly Thr Pro Gly Asn Tyr Ala Glu Leu Arg Met Gly
          1 5 10 15
          Gly Gly Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7163]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7163]]>
          Gly Ser Ala Pro Gly Ala Ser Gly Glu Tyr Ala Glu Leu Arg Met Gly
          1 5 10 15
          Gly Glu Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7164]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7164]]>
          Gly Ser Ala Pro Gly Gly Thr Gly His Tyr Ala Glu Leu Arg Met Gly
          1 5 10 15
          Gly Pro Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7165]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7165]]>
          Gly Ser Ala Pro Gly Glu Ala Gly Gly Tyr Ala Glu Ala Arg Met Gly
          1 5 10 15
          Gly Ser Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7166]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7166]]>
          Gly Ser Ala Pro Gly Pro Gly Gly Gly Tyr Ala Glu Val Arg Met Gly
          1 5 10 15
          Gly Thr Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7167]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7167]]>
          Gly Ser Ala Pro Gly Ser Glu Gly Gly Tyr Ala Glu Ile Arg Met Gly
          1 5 10 15
          Gly Ala Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7168]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7168]]>
          Gly Ser Ala Pro Gly Thr Pro Gly Gly Tyr Ala Glu Phe Arg Met Gly
          1 5 10 15
          Gly Gly Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7169]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7169]]>
          Gly Ser Ala Pro Gly Ala Ser Gly Gly Tyr Ala Glu Tyr Arg Met Gly
          1 5 10 15
          Gly Glu Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7170]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7170]]>
          Gly Ser Ala Pro Gly Gly Thr Gly Gly Tyr Ala Glu Ser Arg Met Gly
          1 5 10 15
          Gly Pro Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7171]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7171]]>
          Gly Ser Ala Pro Gly Glu Ala Gly Gly Tyr Ala Glu Thr Arg Met Gly
          1 5 10 15
          Gly Ser Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7172]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7172]]>
          Gly Ser Ala Pro Gly Pro Gly Gly Gly Tyr Ala Glu Leu Ala Met Gly
          1 5 10 15
          Gly Thr Arg Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7173]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7173]]>
          Gly Ser Ala Pro Gly Ser Glu Gly Gly Tyr Ala Glu Leu Val Met Gly
          1 5 10 15
          Gly Ala Arg Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7174]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7174]]>
          Gly Ser Ala Pro Gly Thr Pro Gly Gly Tyr Ala Glu Leu Leu Met Gly
          1 5 10 15
          Gly Gly Arg Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7175]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7175]]>
          Gly Ser Ala Pro Gly Ala Ser Gly Gly Tyr Ala Glu Leu Ile Met Gly
          1 5 10 15
          Gly Glu Arg Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7176]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7176]]>
          Gly Ser Ala Pro Gly Gly Thr Gly Gly Tyr Ala Glu Leu Trp Met Gly
          1 5 10 15
          Gly Pro Arg Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7177]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7177]]>
          Gly Ser Ala Pro Gly Glu Ala Gly Gly Tyr Ala Glu Leu Ser Met Gly
          1 5 10 15
          Gly Ser Arg Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7178]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7178]]>
          Gly Ser Ala Pro Gly Pro Gly Gly Gly Tyr Ala Glu Leu Thr Met Gly
          1 5 10 15
          Gly Thr Arg Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7179]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7179]]>
          Gly Ser Ala Pro Gly Ser Glu Gly Gly Tyr Ala Glu Leu Gln Met Gly
          1 5 10 15
          Gly Ala Arg Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7180]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7180]]>
          Gly Ser Ala Pro Gly Thr Pro Gly Gly Tyr Ala Glu Leu Asn Met Gly
          1 5 10 15
          Gly Gly Arg Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7181]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7181]]>
          Gly Ser Ala Pro Gly Ala Ser Gly Gly Tyr Ala Glu Leu Glu Met Gly
          1 5 10 15
          Gly Glu Arg Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7182]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7182]]>
          Gly Ser Ala Pro Gly Gly Thr Gly Gly Tyr Ala Glu Leu Arg Pro Gly
          1 5 10 15
          Gly Pro Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7183]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7183]]>
          Gly Ser Ala Pro Gly Glu Ala Gly Gly Tyr Ala Glu Leu Arg Ala Gly
          1 5 10 15
          Gly Ser Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7184]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7184]]>
          Gly Ser Ala Pro Gly Pro Gly Gly Gly Tyr Ala Glu Leu Arg Leu Gly
          1 5 10 15
          Gly Thr Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7185]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7185]]>
          Gly Ser Ala Pro Gly Ser Glu Gly Gly Tyr Ala Glu Leu Arg Ile Gly
          1 5 10 15
          Gly Ala Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7186]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7186]]>
          Gly Ser Ala Pro Gly Thr Pro Gly Gly Tyr Ala Glu Leu Arg Ser Gly
          1 5 10 15
          Gly Gly Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7187]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7187]]>
          Gly Ser Ala Pro Gly Ala Ser Gly Gly Tyr Ala Glu Leu Arg Asn Gly
          1 5 10 15
          Gly Glu Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7188]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7188]]>
          Gly Ser Ala Pro Gly Gly Thr Gly Gly Tyr Ala Glu Leu Arg Gln Gly
          1 5 10 15
          Gly Pro Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7189]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7189]]>
          Gly Ser Ala Pro Gly Glu Ala Gly Gly Tyr Ala Glu Leu Arg Asp Gly
          1 5 10 15
          Gly Ser Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7190]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7190]]>
          Gly Ser Ala Pro Gly Pro Gly Gly Gly Tyr Ala Glu Leu Arg Glu Gly
          1 5 10 15
          Gly Thr Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7191]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7191]]>
          Gly Ser Ala Pro Gly Ser Glu Gly Gly Tyr Ala Glu Leu Arg His Gly
          1 5 10 15
          Gly Ala Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7192]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7192]]>
          Gly Ser Ala Pro Gly Thr Pro Gly Gly Tyr Ala Glu Leu Arg Met Pro
          1 5 10 15
          Gly Gly Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7193]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7193]]>
          Gly Ser Ala Pro Gly Ala Ser Gly Gly Tyr Ala Glu Leu Arg Met Ala
          1 5 10 15
          Gly Glu Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7194]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7194]]>
          Gly Ser Ala Pro Gly Gly Thr Gly Gly Tyr Ala Glu Leu Arg Met Val
          1 5 10 15
          Gly Pro Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7195]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7195]]>
          Gly Ser Ala Pro Gly Glu Ala Gly Gly Tyr Ala Glu Leu Arg Met Leu
          1 5 10 15
          Gly Ser Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7196]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7196]]>
          Gly Ser Ala Pro Gly Pro Gly Gly Gly Tyr Ala Glu Leu Arg Met Ile
          1 5 10 15
          Gly Thr Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7197]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7197]]>
          Gly Ser Ala Pro Gly Ser Glu Gly Gly Tyr Ala Glu Leu Arg Met Tyr
          1 5 10 15
          Gly Ala Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7198]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7198]]>
          Gly Ser Ala Pro Gly Thr Pro Gly Gly Tyr Ala Glu Leu Arg Met Ser
          1 5 10 15
          Gly Gly Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7199]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7199]]>
          Gly Ser Ala Pro Gly Ala Ser Gly Gly Tyr Ala Glu Leu Arg Met Asn
          1 5 10 15
          Gly Glu Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7200]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7200]]>
          Gly Ser Ala Pro Gly Gly Thr Gly Gly Tyr Ala Glu Leu Arg Met Gln
          1 5 10 15
          Gly Pro Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7201]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7201]]>
          Gly Ser Ala Pro Gly Ala Asn His Thr Pro Ala Gly Leu Thr Gly Pro
          1 5 10 15
          Gly Ala Arg Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7202]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7202]]>
          Gly Ser Ala Pro Gly Ala Asn Thr Ala Pro Glu Gly Leu Thr Gly Pro
          1 5 10 15
          Ser Thr Arg Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7203]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7203]]>
          Gly Ser Ala Pro Gly Thr Gly Ala Pro Pro Gly Gly Leu Thr Gly Pro
          1 5 10 15
          Gly Thr Arg Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7204]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7204]]>
          Gly Ser Ala Pro Gly Ala Asn His Glu Pro Ser Gly Leu Thr Glu Gly
          1 5 10 15
          Ser Pro Arg Ala Thr Ser Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7205]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7205]]>
          Gly Ser Ala Pro Gly Ala Asn Thr Glu Pro Pro Glu Leu Gly Ala Gly
          1 5 10 15
          Thr Glu Arg Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7206]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7206]]>
          Gly Ser Ala Pro Gly Ala Ser Gly Pro Pro Pro Gly Leu Thr Gly Pro
          1 5 10 15
          Pro Gly Arg Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7207]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7207]]>
          Gly Ser Ala Pro Gly Ala Ser Gly Thr Pro Ala Pro Leu Gly Gly Glu
          1 5 10 15
          Pro Gly Arg Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7208]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7208]]>
          Gly Ser Ala Pro Gly Pro Ala Gly Pro Pro Glu Gly Leu Glu Thr Glu
          1 5 10 15
          Ala Gly Arg Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7209]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7209]]>
          Gly Ser Ala Pro Gly Pro Thr Ser Gly Gln Gly Gly Leu Thr Gly Pro
          1 5 10 15
          Glu Ser Arg Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7210]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7210]]>
          Gly Ser Ala Pro Gly Ser Ala Gly Gly Ala Ala Asn Leu Val Arg Gly
          1 5 10 15
          Gly Ala Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7211]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7211]]>
          Gly Ser Ala Pro Gly Thr Gly Gly Gly Ala Ala Pro Leu Val Arg Gly
          1 5 10 15
          Gly Gly Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7212]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7212]]>
          Gly Ser Ala Pro Gly Ala Glu Gly Gly Ala Ala Ala Leu Val Arg Gly
          1 5 10 15
          Gly Glu Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7213]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7213]]>
          Gly Ser Ala Pro Gly Gly Gly Pro Gly Gly Ala Ala Leu Leu Val Arg Gly
          1 5 10 15
          Gly Pro Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7214]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7214]]>
          Gly Ser Ala Pro Gly Glu Ala Gly Gly Ala Ala Phe Leu Val Arg Gly
          1 5 10 15
          Gly Ser Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7215]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7215]]>
          Gly Ser Ala Pro Gly Pro Gly Gly Gly Ala Ala Ser Leu Val Arg Gly
          1 5 10 15
          Gly Thr Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7216]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7216]]>
          Gly Ser Ala Pro Gly Ser Glu Gly Gly Ala Ala Thr Leu Val Arg Gly
          1 5 10 15
          Gly Ala Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7217]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7217]]>
          Gly Ser Ala Pro Gly Thr Pro Gly Gly Ala Ala Gly Leu Val Arg Gly
          1 5 10 15
          Gly Gly Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7218]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7218]]>
          Gly Ser Ala Pro Gly Ala Ser Gly Gly Ala Ala Asp Leu Val Arg Gly
          1 5 10 15
          Gly Glu Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7219]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7219]]>
          Gly Ser Ala Pro Gly Gly Thr Gly Gly Ala Gly Asn Leu Val Arg Gly
          1 5 10 15
          Gly Pro Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7220]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7220]]>
          Gly Ser Ala Pro Gly Glu Ala Gly Gly Ala Pro Asn Leu Val Arg Gly
          1 5 10 15
          Gly Ser Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7221]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7221]]>
          Gly Ser Ala Pro Gly Pro Gly Gly Gly Ala Val Asn Leu Val Arg Gly
          1 5 10 15
          Gly Thr Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7222]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7222]]>
          Gly Ser Ala Pro Gly Ser Glu Gly Gly Ala Leu Asn Leu Val Arg Gly
          1 5 10 15
          Gly Ala Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7223]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7223]]>
          Gly Ser Ala Pro Gly Thr Pro Gly Gly Ala Ser Asn Leu Val Arg Gly
          1 5 10 15
          Gly Gly Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7224]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7224]]>
          Gly Ser Ala Pro Gly Ala Ser Gly Gly Ala Thr Asn Leu Val Arg Gly
          1 5 10 15
          Gly Glu Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7225]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7225]]>
          Gly Ser Ala Pro Gly Gly Thr Gly Gly Ala Gln Asn Leu Val Arg Gly
          1 5 10 15
          Gly Pro Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7226]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7226]]>
          Gly Ser Ala Pro Gly Glu Ala Gly Gly Ala Glu Asn Leu Val Arg Gly
          1 5 10 15
          Gly Ser Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25
           <![CDATA[ <210> 7227]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7227]]>
          Gly Ser Ala Pro Glu Ala Gly Arg Ser Ala Asn His Glu Pro Leu Gly
          1 5 10 15
          Leu Val Ala Thr Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7228]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7228]]>
          Gly Ser Ala Pro Ala Ser Gly Arg Ser Thr Asn Ala Gly Pro Ser Gly
          1 5 10 15
          Leu Ala Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7229]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7229]]>
          Gly Ser Ala Pro Ala Ser Gly Arg Ser Thr Asn Ala Gly Pro Gln Gly
          1 5 10 15
          Leu Ala Gly Gln Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7230]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7230]]>
          Gly Ser Ala Pro Ala Ser Gly Arg Ser Thr Asn Ala Gly Pro Pro Gly
          1 5 10 15
          Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7231]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7231]]>
          Gly Ser Ala Pro Ala Ser Ser Arg Gly Thr Asn Ala Gly Pro Ala Gly
          1 5 10 15
          Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7232]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7232]]>
          Gly Ser Ala Pro Ala Ser Ser Arg Thr Thr Asn Thr Gly Pro Ser Thr
          1 5 10 15
          Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7233]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7233]]>
          Gly Ser Ala Pro Ala Ala Gly Arg Ser Asp Asn Gly Thr Pro Leu Glu
          1 5 10 15
          Leu Val Ala Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7234]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7234]]>
          Gly Ser Ala Pro Glu Ala Gly Arg Ser Ala Asn His Glu Pro Leu Gly
          1 5 10 15
          Leu Val Ala Thr Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7235]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7235]]>
          Gly Ser Ala Pro Ala Ser Gly Arg Gly Thr Asn Ala Gly Pro Ala Gly
          1 5 10 15
          Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7236]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7236]]>
          Gly Ser Ala Pro Leu Phe Gly Arg Asn Asp Asn His Glu Pro Leu Glu
          1 5 10 15
          Leu Gly Gly Gly Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7237]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7237]]>
          Gly Ser Ala Pro Thr Ala Gly Arg Ser Asp Asn Leu Glu Pro Leu Gly
          1 5 10 15
          Leu Val Phe Gly Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7238]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7238]]>
          Gly Ser Ala Pro Leu Asp Gly Arg Ser Asp Asn Phe His Pro Pro Glu
          1 5 10 15
          Leu Val Ala Gly Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7239]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7239]]>
          Gly Ser Ala Pro Leu Glu Gly Arg Ser Asp Asn Glu Glu Pro Glu Asn
          1 5 10 15
          Leu Val Ala Gly Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7240]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7240]]>
          Gly Ser Ala Pro Leu Lys Gly Arg Ser Asp Asn Asn Ala Pro Leu Ala
          1 5 10 15
          Leu Val Ala Gly Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7241]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7241]]>
          Gly Ser Ala Pro Val Tyr Ser Arg Gly Thr Asn Ala Gly Pro His Gly
          1 5 10 15
          Leu Thr Gly Arg Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7242]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7242]]>
          Gly Ser Ala Pro Ala Asn Ser Arg Gly Thr Asn Lys Gly Phe Ala Gly
          1 5 10 15
          Leu Ile Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7243]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7243]]>
          Gly Ser Ala Pro Ala Ser Ser Arg Leu Thr Asn Glu Ala Pro Ala Gly
          1 5 10 15
          Leu Thr Ile Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7244]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7244]]>
          Gly Ser Ala Pro Asp Gln Ser Arg Gly Thr Asn Ala Gly Pro Glu Gly
          1 5 10 15
          Leu Thr Asp Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7245]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7245]]>
          Gly Ser Ala Pro Glu Ser Ser Arg Gly Thr Asn Ile Gly Gln Gly Gly
          1 5 10 15
          Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7246]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7246]]>
          Gly Ser Ala Pro Ser Ser Ser Arg Gly Thr Asn Gln Asp Pro Ala Gly
          1 5 10 15
          Leu Thr Ile Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7247]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7247]]>
          Gly Ser Ala Pro Ala Ser Ser Arg Gly Gln Asn His Ser Pro Met Gly
          1 5 10 15
          Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7248]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7248]]>
          Gly Ser Ala Pro Ala Tyr Ser Arg Gly Pro Asn Ala Gly Pro Ala Gly
          1 5 10 15
          Leu Glu Gly Arg Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7249]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7249]]>
          Gly Ser Ala Pro Ala Ser Glu Arg Gly Asn Asn Ala Gly Pro Ala Asn
          1 5 10 15
          Leu Thr Gly Phe Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7250]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7250]]>
          Gly Ser Ala Pro Ala Ser His Arg Gly Thr Asn Pro Lys Pro Ala Ile
          1 5 10 15
          Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7251]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7251]]>
          Gly Ser Ala Pro Met Ser Ser Arg Arg Thr Asn Ala Asn Pro Ala Gln
          1 5 10 15
          Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7252]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7252]]>
          Gly Ser Ala Pro Gly Ala Gly Arg Thr Asp Asn His Glu Pro Leu Glu
          1 5 10 15
          Leu Gly Ala Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7253]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7253]]>
          Gly Ser Ala Pro Leu Ala Gly Arg Ser Glu Asn Thr Ala Pro Leu Glu
          1 5 10 15
          Leu Thr Ala Gly Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7254]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7254]]>
          Gly Ser Ala Pro Leu Glu Gly Arg Pro Asp Asn His Glu Pro Leu Ala
          1 5 10 15
          Leu Val Ala Ser Ala Thr Ser Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7255]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7255]]>
          Gly Ser Ala Pro Leu Ser Gly Arg Ser Asp Asn Glu Glu Pro Leu Ala
          1 5 10 15
          Leu Pro Ala Gly Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7256]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7256]]>
          Gly Ser Ala Pro Glu Ala Gly Arg Thr Asp Asn His Glu Pro Leu Glu
          1 5 10 15
          Leu Ser Ala Pro Ala Thr Ser Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7257]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7257]]>
          Gly Ser Ala Pro Glu Gly Gly Arg Ser Asp Asn His Gly Pro Leu Glu
          1 5 10 15
          Leu Val Ser Gly Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7258]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7258]]>
          Gly Ser Ala Pro Leu Ser Gly Arg Ser Asp Asn Glu Ala Pro Leu Glu
          1 5 10 15
          Leu Glu Ala Gly Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7259]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7259]]>
          Gly Ser Ala Pro Leu Gly Gly Arg Ala Asp Asn His Glu Pro Pro Glu
          1 5 10 15
          Leu Gly Ala Gly Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7260]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7260]]>
          Gly Ser Ala Pro Pro Pro Ser Arg Gly Thr Asn Ala Glu Pro Ala Gly
          1 5 10 15
          Leu Thr Gly Glu Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7261]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7261]]>
          Gly Ser Ala Pro Ala Ser Thr Arg Gly Glu Asn Ala Gly Pro Ala Gly
          1 5 10 15
          Leu Glu Ala Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7262]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7262]]>
          Gly Ser Ala Pro Glu Ser Ser Ser Arg Gly Thr Asn Gly Ala Pro Glu Gly
          1 5 10 15
          Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7263]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7263]]>
          Gly Ser Ala Pro Ala Ser Ser Arg Ala Thr Asn Glu Ser Pro Ala Gly
          1 5 10 15
          Leu Thr Gly Glu Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7264]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7264]]>
          Gly Ser Ala Pro Ala Ser Ser Arg Gly Glu Asn Pro Pro Pro Gly Gly
          1 5 10 15
          Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7265]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7265]]>
          Gly Ser Ala Pro Ala Ala Ser Arg Gly Thr Asn Thr Gly Pro Ala Glu
          1 5 10 15
          Leu Thr Gly Ser Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7266]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7266]]>
          Gly Ser Ala Pro Ala Gly Ser Arg Thr Thr Asn Ala Gly Pro Gly Gly
          1 5 10 15
          Leu Glu Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7267]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7267]]>
          Gly Ser Ala Pro Ala Pro Ser Arg Gly Glu Asn Ala Gly Pro Ala Thr
          1 5 10 15
          Leu Thr Gly Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7268]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7268]]>
          Gly Ser Ala Pro Glu Ser Gly Arg Ala Ala Asn Thr Gly Pro Pro Thr
          1 5 10 15
          Leu Thr Ala Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7269]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7269]]>
          Gly Ser Ala Pro Asn Pro Gly Arg Ala Ala Asn Glu Gly Pro Pro Gly
          1 5 10 15
          Leu Pro Gly Ser Ala Thr Ser Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7270]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7270]]>
          Gly Ser Ala Pro Glu Ser Ser Ser Arg Ala Ala Asn Leu Thr Pro Pro Glu
          1 5 10 15
          Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7271]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7271]]>
          Gly Ser Ala Pro Ala Ser Gly Arg Ala Ala Asn Glu Thr Pro Pro Gly
          1 5 10 15
          Leu Thr Gly Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7272]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7272]]>
          Gly Ser Ala Pro Asn Ser Gly Arg Gly Glu Asn Leu Gly Ala Pro Gly
          1 5 10 15
          Leu Thr Gly Thr Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7273]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7273]]>
          Gly Ser Ala Pro Thr Thr Gly Arg Ala Ala Asn Leu Thr Pro Ala Gly
          1 5 10 15
          Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7274]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7274]]>
          Gly Ser Ala Pro Glu Ala Gly Arg Ser Ala Asn His Thr Pro Ala Gly
          1 5 10 15
          Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7275]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7275]]>
          Gly Ser Ala Pro Glu Ser Gly Arg Ala Ala Asn Thr Thr Pro Ala Gly
          1 5 10 15
          Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7276]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7276]]>
          Gly Ser Ala Pro Thr Thr Gly Arg Ala Thr Glu Ala Ala Asn Leu Thr
          1 5 10 15
          Pro Ala Gly Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7277]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7277]]>
          Gly Ser Ala Pro Thr Thr Gly Arg Ala Glu Glu Ala Ala Asn Leu Thr
          1 5 10 15
          Pro Ala Gly Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7278]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7278]]>
          Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr
          1 5 10 15
          Pro Ala Gly Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7279]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7279]]>
          Gly Ser Ala Pro Thr Thr Gly Arg Ala Thr Glu Ala Ala Asn Ala Thr
          1 5 10 15
          Pro Ala Gly Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7280]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7280]]>
          Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Glu Ala Glu Gly Ala Thr
          1 5 10 15
          Ser Ala Gly Ala Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7281]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7281]]>
          Gly Ser Ala Pro Thr Thr Gly Glu Ala Gly Glu Ala Ala Asn Ala Thr
          1 5 10 15
          Ser Ala Gly Ala Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7282]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7282]]>
          Gly Ser Ala Pro Thr Thr Gly Glu Ala Gly Glu Ala Ala Gly Leu Thr
          1 5 10 15
          Pro Ala Gly Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7283]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7283]]>
          Gly Ser Ala Pro Thr Thr Gly Ala Ala Gly Glu Ala Ala Asn Ala Thr
          1 5 10 15
          Pro Ala Gly Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7284]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7284]]>
          Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Glu Ala Ala Gly Leu Thr
          1 5 10 15
          Pro Ala Gly Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7285]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7285]]>
          Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Ala Thr
          1 5 10 15
          Ser Ala Gly Ala Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7286]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7286]]>
          Gly Ser Ala Pro Thr Thr Gly Glu Ala Gly Glu Ala Ala Gly Ala Thr
          1 5 10 15
          Ser Ala Gly Ala Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7287]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7287]]>
          Gly Ser Ala Pro Glu Ser Gly Arg Ala Ala Asn Thr Glu Pro Pro Glu
          1 5 10 15
          Leu Gly Ala Gly Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7288]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7288]]>
          Gly Ser Ala Pro Glu Ser Gly Arg Ala Ala Asn Thr Ala Pro Glu Gly
          1 5 10 15
          Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7289]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7289]]>
          Gly Ser Ala Pro Glu Pro Gly Arg Ala Ala Asn His Glu Pro Ser Gly
          1 5 10 15
          Leu Thr Glu Gly Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7290]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7290]]>
          Gly Ser Ala Pro Glu Ser Gly Arg Ala Ala Asn His Thr Gly Ala Pro
          1 5 10 15
          Pro Gly Gly Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7291]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7291]]>
          Gly Ser Ala Pro Thr Thr Gly Arg Thr Gly Glu Gly Ala Asn Ala Thr
          1 5 10 15
          Pro Gly Gly Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7292]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7292]]>
          Gly Ser Ala Pro Arg Thr Gly Arg Ser Gly Glu Ala Ala Asn Glu Thr
          1 5 10 15
          Pro Glu Gly Leu Glu Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7293]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7293]]>
          Gly Ser Ala Pro Arg Thr Gly Arg Thr Gly Glu Ser Ala Asn Glu Thr
          1 5 10 15
          Pro Ala Gly Leu Gly Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7294]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7294]]>
          Gly Ser Ala Pro Ser Thr Gly Arg Thr Gly Glu Pro Ala Asn Glu Thr
          1 5 10 15
          Pro Ala Gly Leu Ser Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7295]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7295]]>
          Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Glu Pro Ala Asn Ala Thr
          1 5 10 15
          Pro Thr Gly Leu Ser Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7296]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7296]]>
          Gly Ser Ala Pro Arg Thr Gly Arg Pro Gly Glu Gly Ala Asn Ala Thr
          1 5 10 15
          Pro Thr Gly Leu Pro Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7297]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7297]]>
          Gly Ser Ala Pro Arg Thr Gly Arg Gly Gly Glu Ala Ala Asn Ala Thr
          1 5 10 15
          Pro Ser Gly Leu Gly Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7298]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7298]]>
          Gly Ser Ala Pro Ser Thr Gly Arg Ser Gly Glu Ser Ala Asn Ala Thr
          1 5 10 15
          Pro Gly Gly Leu Gly Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7299]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7299]]>
          Gly Ser Ala Pro Arg Thr Gly Arg Thr Gly Glu Glu Ala Asn Ala Thr
          1 5 10 15
          Pro Ala Gly Leu Pro Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7300]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7300]]>
          Gly Ser Ala Pro Ala Thr Gly Arg Pro Gly Glu Pro Ala Asn Thr Thr
          1 5 10 15
          Pro Glu Gly Leu Glu Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7301]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7301]]>
          Gly Ser Ala Pro Ser Thr Gly Arg Ser Gly Glu Pro Ala Asn Ala Thr
          1 5 10 15
          Pro Gly Gly Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7302]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7302]]>
          Gly Ser Ala Pro Pro Thr Gly Arg Gly Gly Glu Gly Ala Asn Thr Thr
          1 5 10 15
          Pro Thr Gly Leu Pro Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7303]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7303]]>
          Gly Ser Ala Pro Pro Thr Gly Arg Ser Gly Glu Gly Ala Asn Ala Thr
          1 5 10 15
          Pro Ser Gly Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7304]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7304]]>
          Gly Ser Ala Pro Thr Thr Gly Arg Ala Ser Glu Gly Ala Asn Ser Thr
          1 5 10 15
          Pro Ala Pro Leu Thr Glu Pro Ala Thr Ser Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7305]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7305]]>
          Gly Ser Ala Pro Thr Tyr Gly Arg Ala Ala Glu Ala Ala Asn Thr Thr
          1 5 10 15
          Pro Ala Gly Leu Thr Ala Pro Ala Thr Ser Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7306]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7306]]>
          Gly Ser Ala Pro Thr Thr Gly Arg Ala Thr Glu Gly Ala Asn Ala Thr
          1 5 10 15
          Pro Ala Glu Leu Thr Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7307]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7307]]>
          Gly Ser Ala Pro Thr Val Gly Arg Ala Ser Glu Glu Ala Asn Thr Thr
          1 5 10 15
          Pro Ala Ser Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7308]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7308]]>
          Gly Ser Ala Pro Thr Thr Gly Arg Ala Pro Glu Ala Ala Asn Ala Thr
          1 5 10 15
          Pro Ala Pro Leu Thr Gly Pro Ala Thr Ser Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7309]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7309]]>
          Gly Ser Ala Pro Thr Trp Gly Arg Ala Thr Glu Pro Ala Asn Ala Thr
          1 5 10 15
          Pro Ala Pro Leu Thr Ser Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7310]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7310]]>
          Gly Ser Ala Pro Thr Val Gly Arg Ala Ser Glu Ser Ala Asn Ala Thr
          1 5 10 15
          Pro Ala Glu Leu Thr Ser Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7311]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7311]]>
          Gly Ser Ala Pro Thr Val Gly Arg Ala Pro Glu Gly Ala Asn Ser Thr
          1 5 10 15
          Pro Ala Gly Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7312]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7312]]>
          Gly Ser Ala Pro Thr Trp Gly Arg Ala Thr Glu Ala Pro Asn Leu Glu
          1 5 10 15
          Pro Ala Thr Leu Thr Thr Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7313]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7313]]>
          Gly Ser Ala Pro Thr Thr Gly Arg Ala Thr Glu Ala Pro Asn Leu Thr
          1 5 10 15
          Pro Ala Pro Leu Thr Glu Pro Ala Thr Ser Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7314]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7314]]>
          Gly Ser Ala Pro Thr Gln Gly Arg Ala Thr Glu Ala Pro Asn Leu Ser
          1 5 10 15
          Pro Ala Ala Leu Thr Ser Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7315]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7315]]>
          Gly Ser Ala Pro Thr Gln Gly Arg Ala Ala Glu Ala Pro Asn Leu Thr
          1 5 10 15
          Pro Ala Thr Leu Thr Ala Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7316]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7316]]>
          Gly Ser Ala Pro Thr Ser Gly Arg Ala Pro Glu Ala Thr Asn Leu Ala
          1 5 10 15
          Pro Ala Pro Leu Thr Gly Pro Ala Thr Ser Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7317]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7317]]>
          Gly Ser Ala Pro Thr Gln Gly Arg Ala Ala Glu Ala Ala Asn Leu Thr
          1 5 10 15
          Pro Ala Gly Leu Thr Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7318]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7318]]>
          Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Ser Ala Pro Asn Leu Pro
          1 5 10 15
          Pro Thr Gly Leu Thr Thr Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7319]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7319]]>
          Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Gly Ala Glu Asn Leu Pro
          1 5 10 15
          Pro Glu Gly Leu Thr Ala Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7320]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7320]]>
          Gly Ser Ala Pro Thr Thr Ser Ser Arg Ala Gly Thr Ala Thr Asn Leu Thr
          1 5 10 15
          Pro Glu Gly Leu Thr Ala Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7321]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7321]]>
          Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Thr Ala Thr Asn Leu Pro
          1 5 10 15
          Pro Ser Gly Leu Thr Thr Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7322]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7322]]>
          Gly Ser Ala Pro Thr Thr Ala Arg Ala Gly Glu Ala Glu Asn Leu Ser
          1 5 10 15
          Pro Ser Gly Leu Thr Ala Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7323]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7323]]>
          Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Gly Ala Gly Asn Leu Ala
          1 5 10 15
          Pro Gly Gly Leu Thr Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7324]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7324]]>
          Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Thr Ala Thr Asn Leu Pro
          1 5 10 15
          Pro Glu Gly Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7325]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7325]]>
          Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Gly Ala Ala Asn Leu Ala
          1 5 10 15
          Pro Thr Gly Leu Thr Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7326]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7326]]>
          Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Thr Ala Glu Asn Leu Ala
          1 5 10 15
          Pro Ser Gly Leu Thr Thr Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7327]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7327]]>
          Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Ser Ala Thr Asn Leu Gly
          1 5 10 15
          Pro Gly Gly Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7328]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7328]]>
          Gly Ser Ala Pro Thr Thr Ala Arg Ala Gly Gly Ala Glu Asn Leu Thr
          1 5 10 15
          Pro Ala Gly Leu Thr Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7329]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7329]]>
          Gly Ser Ala Pro Thr Thr Ala Arg Ala Gly Ser Ala Glu Asn Leu Ser
          1 5 10 15
          Pro Ser Gly Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7330]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7330]]>
          Gly Ser Ala Pro Thr Thr Ala Arg Ala Gly Gly Ala Gly Asn Leu Ala
          1 5 10 15
          Pro Glu Gly Leu Thr Thr Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7331]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7331]]>
          Gly Ser Ala Pro Thr Thr Ser Arg Ala Gly Ala Ala Glu Asn Leu Thr
          1 5 10 15
          Pro Thr Gly Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7332]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7332]]>
          Gly Ser Ala Pro Thr Tyr Gly Arg Thr Thr Thr Pro Gly Asn Glu Pro
          1 5 10 15
          Pro Ala Ser Leu Glu Ala Glu Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7333]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7333]]>
          Gly Ser Ala Pro Thr Tyr Ser Arg Gly Glu Ser Gly Pro Asn Glu Pro
          1 5 10 15
          Pro Pro Gly Leu Thr Gly Pro Ala Thr Ser Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7334]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7334]]>
          Gly Ser Ala Pro Ala Trp Gly Arg Thr Gly Ala Ser Glu Asn Glu Thr
          1 5 10 15
          Pro Ala Pro Leu Gly Gly Glu Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7335]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7335]]>
          Gly Ser Ala Pro Arg Trp Gly Arg Ala Glu Thr Thr Pro Asn Thr Pro
          1 5 10 15
          Pro Glu Gly Leu Glu Thr Glu Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7336]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7336]]>
          Gly Ser Ala Pro Glu Ser Gly Arg Ala Ala Asn His Thr Gly Ala Glu
          1 5 10 15
          Pro Pro Glu Leu Gly Ala Gly Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7337]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7337]]>
          Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr
          1 5 10 15
          Pro Ala Gly Leu Thr Glu Ser Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7338]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7338]]>
          Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr
          1 5 10 15
          Pro Ala Ala Leu Thr Glu Ser Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7339]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7339]]>
          Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr
          1 5 10 15
          Pro Ala Pro Leu Thr Glu Ser Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7340]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7340]]>
          Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr
          1 5 10 15
          Pro Glu Pro Leu Thr Glu Ser Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7341]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7341]]>
          Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr
          1 5 10 15
          Pro Ala Gly Leu Thr Gly Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7342]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7342]]>
          Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr
          1 5 10 15
          Pro Glu Gly Leu Thr Gly Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7343]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7343]]>
          Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr
          1 5 10 15
          Pro Glu Pro Leu Thr Gly Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7344]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7344]]>
          Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr
          1 5 10 15
          Pro Ala Gly Leu Thr Glu Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7345]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7345]]>
          Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr
          1 5 10 15
          Pro Glu Gly Leu Thr Glu Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7346]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7346]]>
          Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr
          1 5 10 15
          Pro Ala Pro Leu Thr Glu Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7347]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7347]]>
          Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr
          1 5 10 15
          Pro Glu Pro Leu Thr Glu Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7348]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7348]]>
          Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr
          1 5 10 15
          Pro Glu Pro Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7349]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7349]]>
          Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr
          1 5 10 15
          Pro Ala Gly Leu Thr Gly Gly Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7350]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7350]]>
          Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr
          1 5 10 15
          Pro Glu Gly Leu Thr Gly Gly Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7351]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7351]]>
          Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr
          1 5 10 15
          Pro Glu Ala Leu Thr Gly Gly Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7352]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7352]]>
          Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr
          1 5 10 15
          Pro Glu Pro Leu Thr Gly Gly Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7353]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7353]]>
          Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr
          1 5 10 15
          Pro Ala Gly Leu Thr Glu Gly Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7354]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7354]]>
          Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr
          1 5 10 15
          Pro Glu Gly Leu Thr Glu Gly Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7355]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7355]]>
          Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr
          1 5 10 15
          Pro Ala Pro Leu Thr Glu Gly Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7356]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7356]]>
          Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr
          1 5 10 15
          Pro Glu Pro Leu Thr Glu Gly Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7357]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7357]]>
          Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Glu Ala Glu Gly Ala Thr
          1 5 10 15
          Ser Ala Gly Ala Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7358]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7358]]>
          Gly Ser Ala Pro Glu Ala Gly Arg Ser Ala Glu Ala Thr Ser Ala Gly
          1 5 10 15
          Ala Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7359]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7359]]>
          Gly Ser Ala Pro Ser Ala Ser Gly Thr Tyr Ser Arg Gly Glu Ser Gly
          1 5 10 15
          Pro Gly Ser Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7360]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7360]]>
          Gly Ser Ala Pro Ser Ala Ser Gly Glu Ala Gly Arg Thr Asp Thr His
          1 5 10 15
          Pro Gly Ser Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7361]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7361]]>
          Gly Ser Ala Pro Ser Ala Ser Gly Glu Pro Gly Arg Ala Ala Glu His
          1 5 10 15
          Pro Gly Ser Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7362]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7362]]>
          Gly Ser Ala Pro Ser Pro Ala Gly Glu Ser Ser Arg Gly Thr Thr Ile
          1 5 10 15
          Ala Gly Ser Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7363]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7363]]>
          Gly Ser Ala Pro Thr Thr Gly Glu Ala Gly Glu Ala Ala Gly Leu Thr
          1 5 10 15
          Pro Ala Gly Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
                      20 25 30
          Thr
           <![CDATA[ <210> 7364]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7364]]>
          Gly Ser Ala Pro Glu Ala Gly Glu Ser Ala Gly Ala Thr Pro Ala Gly
          1 5 10 15
          Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7365]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7365]]>
          Gly Ser Ala Pro Ser Ala Ser Gly Ala Pro Leu Glu Leu Glu Ala Gly
          1 5 10 15
          Pro Gly Ser Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7366]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7366]]>
          Gly Ser Ala Pro Ser Ala Ser Gly Glu Pro Pro Glu Leu Gly Ala Gly
          1 5 10 15
          Pro Gly Ser Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7367]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7367]]>
          Gly Ser Ala Pro Ser Ala Ser Gly Glu Pro Ser Gly Leu Thr Glu Gly
          1 5 10 15
          Pro Gly Ser Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7368]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7368]]>
          Gly Ser Ala Pro Ser Ala Ser Gly Thr Pro Ala Pro Leu Thr Glu Pro
          1 5 10 15
          Pro Gly Ser Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7369]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7369]]>
          Gly Ser Ala Pro Ser Ala Ser Gly Thr Pro Ala Glu Leu Thr Glu Pro
          1 5 10 15
          Pro Gly Ser Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7370]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7370]]>
          Gly Ser Ala Pro Ser Ala Ser Gly Pro Pro Pro Gly Leu Thr Gly Pro
          1 5 10 15
          Pro Gly Ser Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7371]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7371]]>
          Gly Ser Ala Pro Ser Ala Ser Gly Thr Pro Ala Pro Leu Gly Gly Glu
          1 5 10 15
          Pro Gly Ser Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7372]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7372]]>
          Gly Ser Ala Pro Ser Pro Ala Gly Ala Pro Glu Gly Leu Thr Gly Pro
          1 5 10 15
          Ala Gly Ser Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7373]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7373]]>
          Gly Ser Ala Pro Ser Pro Ala Gly Pro Pro Glu Gly Leu Glu Thr Glu
          1 5 10 15
          Ala Gly Ser Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7374]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7374]]>
          Gly Ser Ala Pro Ser Pro Thr Ser Gly Gln Gly Gly Leu Thr Gly Pro
          1 5 10 15
          Gly Ser Glu Pro Ala Thr Ser Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7375]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7375]]>
          Gly Ser Ala Pro Ser Glu Ser Ala Pro Pro Glu Gly Leu Glu Thr Glu
          1 5 10 15
          Ser Thr Glu Pro Ala Thr Ser Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7376]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7376]]>
          Gly Ser Ala Pro Ser Glu Gly Ser Glu Pro Leu Glu Leu Gly Ala Ala
          1 5 10 15
          Ser Glu Thr Pro Ala Thr Ser Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7377]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7377]]>
          Gly Ser Ala Pro Ser Glu Gly Ser Gly Pro Ala Gly Leu Glu Ala Pro
          1 5 10 15
          Ser Glu Thr Pro Ala Thr Ser Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7378]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7378]]>
          Gly Ser Ala Pro Ser Glu Pro Thr Pro Pro Ala Ser Leu Glu Ala Glu
          1 5 10 15
          Pro Gly Ser Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                      20 25 30
           <![CDATA[ <210> 7379]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7379]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ser Ala Gly Gly Tyr
          1 5 10 15
          Ala Glu Leu Arg Met Gly Gly Ala Ile Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7380]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7380]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Thr Gly Gly Gly Tyr
          1 5 10 15
          Ala Pro Leu Arg Met Gly Gly Gly Ala Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7381]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7381]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ala Glu Gly Gly Tyr
          1 5 10 15
          Ala Ala Leu Arg Met Gly Gly Glu Ile Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7382]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7382]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Gly Pro Gly Gly Tyr
          1 5 10 15
          Ala Leu Leu Arg Met Gly Gly Pro Ala Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7383]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7383]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Glu Ala Gly Gly Tyr
          1 5 10 15
          Ala Phe Leu Arg Met Gly Gly Ser Ile Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7384]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7384]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Pro Gly Gly Gly Tyr
          1 5 10 15
          Ala Ser Leu Arg Met Gly Gly Thr Ala Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7385]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7385]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ser Glu Gly Gly Tyr
          1 5 10 15
          Ala Thr Leu Arg Met Gly Gly Ala Ile Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7386]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7386]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Thr Pro Gly Gly Tyr
          1 5 10 15
          Ala Asn Leu Arg Met Gly Gly Gly Ala Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7387]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7387]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ala Ser Gly Gly Tyr
          1 5 10 15
          Ala His Leu Arg Met Gly Gly Glu Ile Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7388]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7388]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Gly Thr Gly Gly Tyr
          1 5 10 15
          Gly Glu Leu Arg Met Gly Gly Pro Ala Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7389]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7389]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Glu Ala Gly Gly Tyr
          1 5 10 15
          Pro Glu Leu Arg Met Gly Gly Ser Ile Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7390]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7390]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Pro Gly Gly Gly Tyr
          1 5 10 15
          Val Glu Leu Arg Met Gly Gly Thr Ala Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7391]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7391]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ser Glu Gly Gly Tyr
          1 5 10 15
          Leu Glu Leu Arg Met Gly Gly Ala Ile Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7392]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7392]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Thr Pro Gly Gly Tyr
          1 5 10 15
          Ser Glu Leu Arg Met Gly Gly Gly Ala Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7393]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7393]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ala Ser Gly Gly Tyr
          1 5 10 15
          Thr Glu Leu Arg Met Gly Gly Glu Ile Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7394]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7394]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Gly Thr Gly Gly Tyr
          1 5 10 15
          Gln Glu Leu Arg Met Gly Gly Pro Ala Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7395]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7395]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Glu Ala Gly Gly Tyr
          1 5 10 15
          Glu Glu Leu Arg Met Gly Gly Ser Ile Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7396]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7396]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Pro Gly Ile Gly Pro
          1 5 10 15
          Ala Glu Leu Arg Met Gly Gly Thr Ala Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7397]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7397]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ser Glu Ile Gly Ala
          1 5 10 15
          Ala Glu Leu Arg Met Gly Gly Ala Ile Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7398]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7398]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Thr Pro Ile Gly Ser
          1 5 10 15
          Ala Glu Leu Arg Met Gly Gly Gly Ala Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7399]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7399]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ala Ser Ile Gly Thr
          1 5 10 15
          Ala Glu Leu Arg Met Gly Gly Glu Ile Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7400]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7400]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Gly Thr Ile Gly Asn
          1 5 10 15
          Ala Glu Leu Arg Met Gly Gly Pro Ala Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7401]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7401]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Glu Ala Ile Gly Gln
          1 5 10 15
          Ala Glu Leu Arg Met Gly Gly Ser Ile Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7402]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7402]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Pro Gly Gly Pro Tyr
          1 5 10 15
          Ala Glu Leu Arg Met Gly Gly Thr Ala Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7403]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7403]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ser Glu Gly Ala Tyr
          1 5 10 15
          Ala Glu Leu Arg Met Gly Gly Ala Ile Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7404]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7404]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Thr Pro Gly Val Tyr
          1 5 10 15
          Ala Glu Leu Arg Met Gly Gly Gly Ala Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7405]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7405]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ala Ser Gly Leu Tyr
          1 5 10 15
          Ala Glu Leu Arg Met Gly Gly Glu Ile Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7406]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7406]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Gly Thr Gly Ile Tyr
          1 5 10 15
          Ala Glu Leu Arg Met Gly Gly Pro Ala Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7407]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7407]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Glu Ala Gly Phe Tyr
          1 5 10 15
          Ala Glu Leu Arg Met Gly Gly Ser Ile Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7408]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7408]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Pro Gly Gly Tyr Tyr
          1 5 10 15
          Ala Glu Leu Arg Met Gly Gly Thr Ala Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7409]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7409]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ser Glu Gly Ser Tyr
          1 5 10 15
          Ala Glu Leu Arg Met Gly Gly Ala Ile Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7410]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7410]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Thr Pro Gly Asn Tyr
          1 5 10 15
          Ala Glu Leu Arg Met Gly Gly Gly Ala Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7411]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7411]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ala Ser Gly Glu Tyr
          1 5 10 15
          Ala Glu Leu Arg Met Gly Gly Glu Ile Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7412]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7412]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Gly Thr Gly His Tyr
          1 5 10 15
          Ala Glu Leu Arg Met Gly Gly Pro Ala Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7413]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7413]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Glu Ala Gly Gly Tyr
          1 5 10 15
          Ala Glu Ala Arg Met Gly Gly Ser Ile Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7414]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7414]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Pro Gly Gly Gly Tyr
          1 5 10 15
          Ala Glu Val Arg Met Gly Gly Thr Ala Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7415]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7415]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ser Glu Gly Gly Tyr
          1 5 10 15
          Ala Glu Ile Arg Met Gly Gly Ala Ile Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7416]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7416]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Thr Pro Gly Gly Tyr
          1 5 10 15
          Ala Glu Phe Arg Met Gly Gly Gly Ala Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7417]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7417]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ala Ser Gly Gly Tyr
          1 5 10 15
          Ala Glu Tyr Arg Met Gly Gly Glu Ile Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7418]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7418]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Gly Thr Gly Gly Tyr
          1 5 10 15
          Ala Glu Ser Arg Met Gly Gly Pro Ala Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7419]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7419]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Glu Ala Gly Gly Tyr
          1 5 10 15
          Ala Glu Thr Arg Met Gly Gly Ser Ile Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7420]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7420]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Pro Gly Gly Gly Tyr
          1 5 10 15
          Ala Glu Leu Ala Met Gly Gly Thr Arg Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7421]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7421]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ser Glu Gly Gly Tyr
          1 5 10 15
          Ala Glu Leu Val Met Gly Gly Ala Arg Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7422]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7422]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Thr Pro Gly Gly Tyr
          1 5 10 15
          Ala Glu Leu Leu Met Gly Gly Gly Arg Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7423]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7423]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ala Ser Gly Gly Tyr
          1 5 10 15
          Ala Glu Leu Ile Met Gly Gly Glu Arg Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7424]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7424]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Gly Thr Gly Gly Tyr
          1 5 10 15
          Ala Glu Leu Trp Met Gly Gly Pro Arg Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7425]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7425]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Glu Ala Gly Gly Tyr
          1 5 10 15
          Ala Glu Leu Ser Met Gly Gly Ser Arg Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7426]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7426]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Pro Gly Gly Gly Tyr
          1 5 10 15
          Ala Glu Leu Thr Met Gly Gly Thr Arg Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7427]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7427]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ser Glu Gly Gly Tyr
          1 5 10 15
          Ala Glu Leu Gln Met Gly Gly Ala Arg Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7428]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7428]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Thr Pro Gly Gly Tyr
          1 5 10 15
          Ala Glu Leu Asn Met Gly Gly Gly Arg Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7429]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7429]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ala Ser Gly Gly Tyr
          1 5 10 15
          Ala Glu Leu Glu Met Gly Gly Glu Arg Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7430]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7430]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Gly Thr Gly Gly Tyr
          1 5 10 15
          Ala Glu Leu Arg Pro Gly Gly Pro Ile Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7431]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7431]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Glu Ala Gly Gly Tyr
          1 5 10 15
          Ala Glu Leu Arg Ala Gly Gly Ser Ala Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7432]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7432]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Pro Gly Gly Gly Tyr
          1 5 10 15
          Ala Glu Leu Arg Leu Gly Gly Thr Ile Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7433]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7433]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ser Glu Gly Gly Tyr
          1 5 10 15
          Ala Glu Leu Arg Ile Gly Gly Ala Ala Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7434]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7434]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Thr Pro Gly Gly Tyr
          1 5 10 15
          Ala Glu Leu Arg Ser Gly Gly Gly Ile Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7435]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7435]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ala Ser Gly Gly Tyr
          1 5 10 15
          Ala Glu Leu Arg Asn Gly Gly Glu Ala Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7436]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7436]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Gly Thr Gly Gly Tyr
          1 5 10 15
          Ala Glu Leu Arg Gln Gly Gly Pro Ile Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7437]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7437]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Glu Ala Gly Gly Tyr
          1 5 10 15
          Ala Glu Leu Arg Asp Gly Gly Ser Ala Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7438]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7438]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Pro Gly Gly Gly Tyr
          1 5 10 15
          Ala Glu Leu Arg Glu Gly Gly Thr Ile Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7439]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7439]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ser Glu Gly Gly Tyr
          1 5 10 15
          Ala Glu Leu Arg His Gly Gly Ala Ala Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7440]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7440]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Thr Pro Gly Gly Tyr
          1 5 10 15
          Ala Glu Leu Arg Met Pro Gly Gly Ile Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7441]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7441]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ala Ser Gly Gly Tyr
          1 5 10 15
          Ala Glu Leu Arg Met Ala Gly Glu Ala Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7442]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7442]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Gly Thr Gly Gly Tyr
          1 5 10 15
          Ala Glu Leu Arg Met Val Gly Pro Ile Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7443]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7443]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Glu Ala Gly Gly Tyr
          1 5 10 15
          Ala Glu Leu Arg Met Leu Gly Ser Ala Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7444]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7444]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Pro Gly Gly Gly Tyr
          1 5 10 15
          Ala Glu Leu Arg Met Ile Gly Thr Ile Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7445]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7445]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ser Glu Gly Gly Tyr
          1 5 10 15
          Ala Glu Leu Arg Met Tyr Gly Ala Ile Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7446]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7446]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Thr Pro Gly Gly Tyr
          1 5 10 15
          Ala Glu Leu Arg Met Ser Gly Gly Ala Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7447]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7447]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ala Ser Gly Gly Tyr
          1 5 10 15
          Ala Glu Leu Arg Met Asn Gly Glu Ile Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7448]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7448]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Gly Thr Gly Gly Tyr
          1 5 10 15
          Ala Glu Leu Arg Met Gln Gly Pro Ala Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7449]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7449]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ala Asn His Thr Pro
          1 5 10 15
          Ala Gly Leu Thr Gly Pro Gly Ala Arg Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7450]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7450]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ala Asn Thr Ala Pro
          1 5 10 15
          Glu Gly Leu Thr Gly Pro Ser Thr Arg Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7451]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7451]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Thr Gly Ala Pro Pro
          1 5 10 15
          Gly Gly Leu Thr Gly Pro Gly Thr Arg Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7452]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7452]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ala Asn His Glu Pro
          1 5 10 15
          Ser Gly Leu Thr Glu Gly Ser Pro Arg Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7453]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7453]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ala Asn Thr Glu Pro
          1 5 10 15
          Pro Glu Leu Gly Ala Gly Thr Glu Arg Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7454]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7454]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ala Ser Gly Pro Pro
          1 5 10 15
          Pro Gly Leu Thr Gly Pro Pro Gly Arg Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7455]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7455]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ala Ser Gly Thr Pro
          1 5 10 15
          Ala Pro Leu Gly Gly Glu Pro Gly Arg Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7456]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7456]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Pro Ala Gly Pro Pro
          1 5 10 15
          Glu Gly Leu Glu Thr Glu Ala Gly Arg Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7457]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7457]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Pro Thr Ser Gly Gln
          1 5 10 15
          Gly Gly Leu Thr Gly Pro Glu Ser Arg Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7458]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7458]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ser Ala Gly Gly Ala
          1 5 10 15
          Ala Asn Leu Val Arg Gly Gly Ala Ile Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7459]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7459]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Thr Gly Gly Gly Ala
          1 5 10 15
          Ala Pro Leu Val Arg Gly Gly Gly Ala Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7460]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7460]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ala Glu Gly Gly Ala
          1 5 10 15
          Ala Ala Leu Val Arg Gly Gly Glu Ile Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7461]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7461]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Gly Pro Gly Gly Ala
          1 5 10 15
          Ala Leu Leu Val Arg Gly Gly Pro Ala Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7462]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7462]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Glu Ala Gly Gly Ala
          1 5 10 15
          Ala Phe Leu Val Arg Gly Gly Ser Ile Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7463]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7463]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Pro Gly Gly Gly Ala
          1 5 10 15
          Ala Ser Leu Val Arg Gly Gly Thr Ala Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7464]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7464]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ser Glu Gly Gly Ala
          1 5 10 15
          Ala Thr Leu Val Arg Gly Gly Ala Ile Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7465]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7465]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Thr Pro Gly Gly Ala
          1 5 10 15
          Ala Gly Leu Val Arg Gly Gly Gly Ala Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7466]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7466]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ala Ser Gly Gly Ala
          1 5 10 15
          Ala Asp Leu Val Arg Gly Gly Glu Ile Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7467]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7467]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Gly Thr Gly Gly Ala
          1 5 10 15
          Gly Asn Leu Val Arg Gly Gly Pro Ala Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7468]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7468]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Glu Ala Gly Gly Ala
          1 5 10 15
          Pro Asn Leu Val Arg Gly Gly Ser Ile Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7469]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7469]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Pro Gly Gly Gly Ala
          1 5 10 15
          Val Asn Leu Val Arg Gly Gly Thr Ala Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7470]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7470]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ser Glu Gly Gly Ala
          1 5 10 15
          Leu Asn Leu Val Arg Gly Gly Ala Ile Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7471]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7471]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Thr Pro Gly Gly Ala
          1 5 10 15
          Ser Asn Leu Val Arg Gly Gly Gly Ala Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7472]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7472]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ala Ser Gly Gly Ala
          1 5 10 15
          Thr Asn Leu Val Arg Gly Gly Glu Ile Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7473]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7473]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Gly Thr Gly Gly Ala
          1 5 10 15
          Gln Asn Leu Val Arg Gly Gly Pro Ala Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7474]]>
           <![CDATA[ <211> 29]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7474]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Glu Ala Gly Gly Ala
          1 5 10 15
          Glu Asn Leu Val Arg Gly Gly Ser Ile Pro Gly Ser Pro
                      20 25
           <![CDATA[ <210> 7475]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7475]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Glu Ala Gly Arg Ser Ala
          1 5 10 15
          Asn His Glu Pro Leu Gly Leu Val Ala Thr Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7476]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7476]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ala Ser Gly Arg Ser Thr
          1 5 10 15
          Asn Ala Gly Pro Ser Gly Leu Ala Gly Pro Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7477]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7477]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ala Ser Gly Arg Ser Thr
          1 5 10 15
          Asn Ala Gly Pro Gln Gly Leu Ala Gly Gln Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7478]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7478]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ala Ser Gly Arg Ser Thr
          1 5 10 15
          Asn Ala Gly Pro Pro Gly Leu Thr Gly Pro Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7479]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7479]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ala Ser Ser Arg Gly Thr
          1 5 10 15
          Asn Ala Gly Pro Ala Gly Leu Thr Gly Pro Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7480]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7480]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ala Ser Ser Arg Thr Thr
          1 5 10 15
          Asn Thr Gly Pro Ser Thr Leu Thr Gly Pro Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7481]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7481]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ala Ala Gly Arg Ser Asp
          1 5 10 15
          Asn Gly Thr Pro Leu Glu Leu Val Ala Pro Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7482]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7482]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Glu Ala Gly Arg Ser Ala
          1 5 10 15
          Asn His Glu Pro Leu Gly Leu Val Ala Thr Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7483]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7483]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ala Ser Gly Arg Gly Thr
          1 5 10 15
          Asn Ala Gly Pro Ala Gly Leu Thr Gly Pro Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7484]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7484]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Leu Phe Gly Arg Asn Asp
          1 5 10 15
          Asn His Glu Pro Leu Glu Leu Gly Gly Gly Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7485]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7485]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Ala Gly Arg Ser Asp
          1 5 10 15
          Asn Leu Glu Pro Leu Gly Leu Val Phe Gly Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7486]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7486]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Leu Asp Gly Arg Ser Asp
          1 5 10 15
          Asn Phe His Pro Pro Glu Leu Val Ala Gly Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7487]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7487]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Leu Glu Gly Arg Ser Asp
          1 5 10 15
          Asn Glu Glu Pro Glu Asn Leu Val Ala Gly Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7488]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7488]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Leu Lys Gly Arg Ser Asp
          1 5 10 15
          Asn Asn Ala Pro Leu Ala Leu Val Ala Gly Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7489]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7489]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Val Tyr Ser Arg Gly Thr
          1 5 10 15
          Asn Ala Gly Pro His Gly Leu Thr Gly Arg Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7490]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7490]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ala Asn Ser Arg Gly Thr
          1 5 10 15
          Asn Lys Gly Phe Ala Gly Leu Ile Gly Pro Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7491]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7491]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ala Ser Ser Arg Leu Thr
          1 5 10 15
          Asn Glu Ala Pro Ala Gly Leu Thr Ile Pro Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7492]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7492]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Asp Gln Ser Arg Gly Thr
          1 5 10 15
          Asn Ala Gly Pro Glu Gly Leu Thr Asp Pro Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7493]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7493]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Glu Ser Ser Arg Gly Thr
          1 5 10 15
          Asn Ile Gly Gln Gly Gly Leu Thr Gly Pro Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7494]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7494]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ser Ser Ser Arg Gly Thr
          1 5 10 15
          Asn Gln Asp Pro Ala Gly Leu Thr Ile Pro Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7495]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7495]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ala Ser Ser Arg Gly Gln
          1 5 10 15
          Asn His Ser Pro Met Gly Leu Thr Gly Pro Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7496]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7496]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ala Tyr Ser Arg Gly Pro
          1 5 10 15
          Asn Ala Gly Pro Ala Gly Leu Glu Gly Arg Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7497]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7497]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ala Ser Glu Arg Gly Asn
          1 5 10 15
          Asn Ala Gly Pro Ala Asn Leu Thr Gly Phe Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7498]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7498]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ala Ser His Arg Gly Thr
          1 5 10 15
          Asn Pro Lys Pro Ala Ile Leu Thr Gly Pro Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7499]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7499]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Met Ser Ser Arg Arg Thr
          1 5 10 15
          Asn Ala Asn Pro Ala Gln Leu Thr Gly Pro Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7500]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7500]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ala Gly Arg Thr Asp
          1 5 10 15
          Asn His Glu Pro Leu Glu Leu Gly Ala Ala Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7501]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7501]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Leu Ala Gly Arg Ser Glu
          1 5 10 15
          Asn Thr Ala Pro Leu Glu Leu Thr Ala Gly Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7502]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7502]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Leu Glu Gly Arg Pro Asp
          1 5 10 15
          Asn His Glu Pro Leu Ala Leu Val Ala Ser Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7503]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7503]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Leu Ser Gly Arg Ser Asp
          1 5 10 15
          Asn Glu Glu Pro Leu Ala Leu Pro Ala Gly Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7504]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7504]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Glu Ala Gly Arg Thr Asp
          1 5 10 15
          Asn His Glu Pro Leu Glu Leu Ser Ala Pro Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7505]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7505]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Glu Gly Gly Arg Ser Asp
          1 5 10 15
          Asn His Gly Pro Leu Glu Leu Val Ser Gly Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7506]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7506]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Leu Ser Gly Arg Ser Asp
          1 5 10 15
          Asn Glu Ala Pro Leu Glu Leu Glu Ala Gly Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7507]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7507]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Leu Gly Gly Arg Ala Asp
          1 5 10 15
          Asn His Glu Pro Pro Glu Leu Gly Ala Gly Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7508]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7508]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Pro Pro Ser Arg Gly Thr
          1 5 10 15
          Asn Ala Glu Pro Ala Gly Leu Thr Gly Glu Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7509]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7509]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ala Ser Thr Arg Gly Glu
          1 5 10 15
          Asn Ala Gly Pro Ala Gly Leu Glu Ala Pro Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7510]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7510]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Glu Ser Ser Arg Gly Thr
          1 5 10 15
          Asn Gly Ala Pro Glu Gly Leu Thr Gly Pro Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7511]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7511]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ala Ser Ser Arg Ala Thr
          1 5 10 15
          Asn Glu Ser Pro Ala Gly Leu Thr Gly Glu Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7512]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7512]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ala Ser Ser Arg Gly Glu
          1 5 10 15
          Asn Pro Pro Pro Gly Gly Leu Thr Gly Pro Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7513]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7513]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ala Ala Ser Arg Gly Thr
          1 5 10 15
          Asn Thr Gly Pro Ala Glu Leu Thr Gly Ser Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7514]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7514]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ala Gly Ser Arg Thr Thr
          1 5 10 15
          Asn Ala Gly Pro Gly Gly Leu Glu Gly Pro Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7515]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7515]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ala Pro Ser Arg Gly Glu
          1 5 10 15
          Asn Ala Gly Pro Ala Thr Leu Thr Gly Ala Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7516]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7516]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Glu Ser Gly Arg Ala Ala
          1 5 10 15
          Asn Thr Gly Pro Pro Thr Leu Thr Ala Pro Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7517]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7517]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Asn Pro Gly Arg Ala Ala
          1 5 10 15
          Asn Glu Gly Pro Pro Gly Leu Pro Gly Ser Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7518]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7518]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Glu Ser Ser Arg Ala Ala
          1 5 10 15
          Asn Leu Thr Pro Pro Glu Leu Thr Gly Pro Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7519]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7519]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ala Ser Gly Arg Ala Ala
          1 5 10 15
          Asn Glu Thr Pro Pro Gly Leu Thr Gly Ala Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7520]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7520]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Asn Ser Gly Arg Gly Glu
          1 5 10 15
          Asn Leu Gly Ala Pro Gly Leu Thr Gly Thr Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7521]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7521]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Ala
          1 5 10 15
          Asn Leu Thr Pro Ala Gly Leu Thr Gly Pro Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7522]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7522]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Glu Ala Gly Arg Ser Ala
          1 5 10 15
          Asn His Thr Pro Ala Gly Leu Thr Gly Pro Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7523]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7523]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Glu Ser Gly Arg Ala Ala
          1 5 10 15
          Asn Thr Thr Pro Ala Gly Leu Thr Gly Pro Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7524]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7524]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Thr
          1 5 10 15
          Glu Ala Ala Asn Leu Thr Pro Ala Gly Leu Thr Gly Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7525]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7525]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Glu
          1 5 10 15
          Glu Ala Ala Asn Leu Thr Pro Ala Gly Leu Thr Gly Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7526]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7526]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly
          1 5 10 15
          Glu Ala Ala Asn Leu Thr Pro Ala Gly Leu Thr Gly Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7527]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7527]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Thr
          1 5 10 15
          Glu Ala Ala Asn Ala Thr Pro Ala Gly Leu Thr Gly Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7528]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7528]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly
          1 5 10 15
          Glu Ala Glu Gly Ala Thr Ser Ala Gly Ala Thr Gly Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7529]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7529]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Glu Ala Gly
          1 5 10 15
          Glu Ala Ala Asn Ala Thr Ser Ala Gly Ala Thr Gly Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7530]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7530]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Glu Ala Gly
          1 5 10 15
          Glu Ala Ala Gly Leu Thr Pro Ala Gly Leu Thr Gly Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7531]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7531]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Ala Ala Gly
          1 5 10 15
          Glu Ala Ala Asn Ala Thr Pro Ala Gly Leu Thr Gly Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7532]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7532]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly
          1 5 10 15
          Glu Ala Ala Gly Leu Thr Pro Ala Gly Leu Thr Gly Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7533]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7533]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly
          1 5 10 15
          Glu Ala Ala Asn Ala Thr Ser Ala Gly Ala Thr Gly Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7534]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7534]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Glu Ala Gly
          1 5 10 15
          Glu Ala Ala Gly Ala Thr Ser Ala Gly Ala Thr Gly Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7535]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7535]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Glu Ser Gly Arg Ala Ala
          1 5 10 15
          Asn Thr Glu Pro Pro Glu Leu Gly Ala Gly Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7536]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7536]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Glu Ser Gly Arg Ala Ala
          1 5 10 15
          Asn Thr Ala Pro Glu Gly Leu Thr Gly Pro Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7537]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7537]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Glu Pro Gly Arg Ala Ala
          1 5 10 15
          Asn His Glu Pro Ser Gly Leu Thr Glu Gly Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7538]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7538]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Glu Ser Gly Arg Ala Ala
          1 5 10 15
          Asn His Thr Gly Ala Pro Pro Gly Gly Leu Thr Gly Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7539]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7539]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Thr Gly
          1 5 10 15
          Glu Gly Ala Asn Ala Thr Pro Gly Gly Leu Thr Gly Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7540]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7540]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Arg Thr Gly Arg Ser Gly
          1 5 10 15
          Glu Ala Ala Asn Glu Thr Pro Glu Gly Leu Glu Gly Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7541]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7541]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Arg Thr Gly Arg Thr Gly
          1 5 10 15
          Glu Ser Ala Asn Glu Thr Pro Ala Gly Leu Gly Gly Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7542]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7542]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ser Thr Gly Arg Thr Gly
          1 5 10 15
          Glu Pro Ala Asn Glu Thr Pro Ala Gly Leu Ser Gly Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7543]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7543]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly
          1 5 10 15
          Glu Pro Ala Asn Ala Thr Pro Thr Gly Leu Ser Gly Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7544]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7544]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Arg Thr Gly Arg Pro Gly
          1 5 10 15
          Glu Gly Ala Asn Ala Thr Pro Thr Gly Leu Pro Gly Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7545]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7545]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Arg Thr Gly Arg Gly Gly
          1 5 10 15
          Glu Ala Ala Asn Ala Thr Pro Ser Gly Leu Gly Gly Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7546]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7546]]>
          Gly Thr Ala Glu Ala Ala Ser Ser Ala Ser Gly Ser Thr Gly Arg Ser Gly
          1 5 10 15
          Glu Ser Ala Asn Ala Thr Pro Gly Gly Leu Gly Gly Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7547]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7547]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Arg Thr Gly Arg Thr Gly
          1 5 10 15
          Glu Glu Ala Asn Ala Thr Pro Ala Gly Leu Pro Gly Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7548]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7548]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ala Thr Gly Arg Pro Gly
          1 5 10 15
          Glu Pro Ala Asn Thr Thr Pro Glu Gly Leu Glu Gly Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7549]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7549]]>
          Gly Thr Ala Glu Ala Ala Ser Ser Ala Ser Gly Ser Thr Gly Arg Ser Gly
          1 5 10 15
          Glu Pro Ala Asn Ala Thr Pro Gly Gly Leu Thr Gly Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7550]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7550]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Pro Thr Gly Arg Gly Gly
          1 5 10 15
          Glu Gly Ala Asn Thr Thr Pro Thr Gly Leu Pro Gly Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7551]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7551]]>
          Gly Thr Ala Glu Ala Ala Ser Ser Ala Ser Gly Pro Thr Gly Arg Ser Gly
          1 5 10 15
          Glu Gly Ala Asn Ala Thr Pro Ser Gly Leu Thr Gly Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7552]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7552]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Ser
          1 5 10 15
          Glu Gly Ala Asn Ser Thr Pro Ala Pro Leu Thr Glu Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7553]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7553]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Tyr Gly Arg Ala Ala
          1 5 10 15
          Glu Ala Ala Asn Thr Thr Pro Ala Gly Leu Thr Ala Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7554]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7554]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Thr
          1 5 10 15
          Glu Gly Ala Asn Ala Thr Pro Ala Glu Leu Thr Glu Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7555]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7555]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Val Gly Arg Ala Ser
          1 5 10 15
          Glu Glu Ala Asn Thr Thr Pro Ala Ser Leu Thr Gly Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7556]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7556]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Pro
          1 5 10 15
          Glu Ala Ala Asn Ala Thr Pro Ala Pro Leu Thr Gly Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7557]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7557]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Trp Gly Arg Ala Thr
          1 5 10 15
          Glu Pro Ala Asn Ala Thr Pro Ala Pro Leu Thr Ser Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7558]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7558]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Val Gly Arg Ala Ser
          1 5 10 15
          Glu Ser Ala Asn Ala Thr Pro Ala Glu Leu Thr Ser Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7559]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7559]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Val Gly Arg Ala Pro
          1 5 10 15
          Glu Gly Ala Asn Ser Thr Pro Ala Gly Leu Thr Gly Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7560]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7560]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Trp Gly Arg Ala Thr
          1 5 10 15
          Glu Ala Pro Asn Leu Glu Pro Ala Thr Leu Thr Thr Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7561]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7561]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Thr
          1 5 10 15
          Glu Ala Pro Asn Leu Thr Pro Ala Pro Leu Thr Glu Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7562]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7562]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Gln Gly Arg Ala Thr
          1 5 10 15
          Glu Ala Pro Asn Leu Ser Pro Ala Ala Leu Thr Ser Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7563]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7563]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Gln Gly Arg Ala Ala
          1 5 10 15
          Glu Ala Pro Asn Leu Thr Pro Ala Thr Leu Thr Ala Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7564]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7564]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Ser Gly Arg Ala Pro
          1 5 10 15
          Glu Ala Thr Asn Leu Ala Pro Ala Pro Leu Thr Gly Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7565]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7565]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Gln Gly Arg Ala Ala
          1 5 10 15
          Glu Ala Ala Asn Leu Thr Pro Ala Gly Leu Thr Glu Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7566]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7566]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly
          1 5 10 15
          Ser Ala Pro Asn Leu Pro Pro Thr Gly Leu Thr Thr Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7567]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7567]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly
          1 5 10 15
          Gly Ala Glu Asn Leu Pro Pro Glu Gly Leu Thr Ala Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7568]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7568]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Ser Arg Ala Gly
          1 5 10 15
          Thr Ala Thr Asn Leu Thr Pro Glu Gly Leu Thr Ala Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7569]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7569]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly
          1 5 10 15
          Thr Ala Thr Asn Leu Pro Pro Ser Gly Leu Thr Thr Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7570]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7570]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Ala Arg Ala Gly
          1 5 10 15
          Glu Ala Glu Asn Leu Ser Pro Ser Gly Leu Thr Ala Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7571]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7571]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly
          1 5 10 15
          Gly Ala Gly Asn Leu Ala Pro Gly Gly Leu Thr Glu Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7572]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7572]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly
          1 5 10 15
          Thr Ala Thr Asn Leu Pro Pro Glu Gly Leu Thr Gly Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7573]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7573]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly
          1 5 10 15
          Gly Ala Ala Asn Leu Ala Pro Thr Gly Leu Thr Glu Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7574]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7574]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly
          1 5 10 15
          Thr Ala Glu Asn Leu Ala Pro Ser Gly Leu Thr Thr Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7575]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7575]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly
          1 5 10 15
          Ser Ala Thr Asn Leu Gly Pro Gly Gly Leu Thr Gly Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7576]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7576]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Ala Arg Ala Gly
          1 5 10 15
          Gly Ala Glu Asn Leu Thr Pro Ala Gly Leu Thr Glu Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7577]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7577]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Ala Arg Ala Gly
          1 5 10 15
          Ser Ala Glu Asn Leu Ser Pro Ser Gly Leu Thr Gly Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7578]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7578]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Ala Arg Ala Gly
          1 5 10 15
          Gly Ala Gly Asn Leu Ala Pro Glu Gly Leu Thr Thr Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7579]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7579]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Ser Arg Ala Gly
          1 5 10 15
          Ala Ala Glu Asn Leu Thr Pro Thr Gly Leu Thr Gly Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7580]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7580]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Tyr Gly Arg Thr Thr
          1 5 10 15
          Thr Pro Gly Asn Glu Pro Pro Ala Ser Leu Glu Ala Glu Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7581]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7581]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Tyr Ser Arg Gly Glu
          1 5 10 15
          Ser Gly Pro Asn Glu Pro Pro Pro Gly Leu Thr Gly Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7582]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7582]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ala Trp Gly Arg Thr Gly
          1 5 10 15
          Ala Ser Glu Asn Glu Thr Pro Ala Pro Leu Gly Gly Glu Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7583]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7583]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Arg Trp Gly Arg Ala Glu
          1 5 10 15
          Thr Thr Pro Asn Thr Pro Pro Glu Gly Leu Glu Thr Glu Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7584]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7584]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Glu Ser Gly Arg Ala Ala
          1 5 10 15
          Asn His Thr Gly Ala Glu Pro Pro Glu Leu Gly Ala Gly Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7585]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7585]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly
          1 5 10 15
          Glu Ala Ala Asn Leu Thr Pro Ala Gly Leu Thr Glu Ser Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7586]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7586]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly
          1 5 10 15
          Glu Ala Ala Asn Leu Thr Pro Ala Ala Leu Thr Glu Ser Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7587]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7587]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly
          1 5 10 15
          Glu Ala Ala Asn Leu Thr Pro Ala Pro Leu Thr Glu Ser Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7588]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7588]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly
          1 5 10 15
          Glu Ala Ala Asn Leu Thr Pro Glu Pro Leu Thr Glu Ser Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7589]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7589]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly
          1 5 10 15
          Glu Ala Ala Asn Leu Thr Pro Ala Gly Leu Thr Gly Ala Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7590]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7590]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly
          1 5 10 15
          Glu Ala Ala Asn Leu Thr Pro Glu Gly Leu Thr Gly Ala Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7591]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7591]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly
          1 5 10 15
          Glu Ala Ala Asn Leu Thr Pro Glu Pro Leu Thr Gly Ala Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7592]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7592]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly
          1 5 10 15
          Glu Ala Ala Asn Leu Thr Pro Ala Gly Leu Thr Glu Ala Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7593]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7593]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly
          1 5 10 15
          Glu Ala Ala Asn Leu Thr Pro Glu Gly Leu Thr Glu Ala Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7594]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7594]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly
          1 5 10 15
          Glu Ala Ala Asn Leu Thr Pro Ala Pro Leu Thr Glu Ala Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7595]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7595]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly
          1 5 10 15
          Glu Ala Ala Asn Leu Thr Pro Glu Pro Leu Thr Glu Ala Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7596]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7596]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly
          1 5 10 15
          Glu Ala Ala Asn Leu Thr Pro Glu Pro Leu Thr Gly Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7597]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7597]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly
          1 5 10 15
          Glu Ala Ala Asn Leu Thr Pro Ala Gly Leu Thr Gly Gly Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7598]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7598]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly
          1 5 10 15
          Glu Ala Ala Asn Leu Thr Pro Glu Gly Leu Thr Gly Gly Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7599]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7599]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly
          1 5 10 15
          Glu Ala Ala Asn Leu Thr Pro Glu Ala Leu Thr Gly Gly Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7600]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7600]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly
          1 5 10 15
          Glu Ala Ala Asn Leu Thr Pro Glu Pro Leu Thr Gly Gly Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7601]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7601]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly
          1 5 10 15
          Glu Ala Ala Asn Leu Thr Pro Ala Gly Leu Thr Glu Gly Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7602]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7602]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly
          1 5 10 15
          Glu Ala Ala Asn Leu Thr Pro Glu Gly Leu Thr Glu Gly Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7603]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7603]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly
          1 5 10 15
          Glu Ala Ala Asn Leu Thr Pro Ala Pro Leu Thr Glu Gly Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7604]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7604]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly
          1 5 10 15
          Glu Ala Ala Asn Leu Thr Pro Glu Pro Leu Thr Glu Gly Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7605]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7605]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly
          1 5 10 15
          Glu Ala Glu Gly Ala Thr Ser Ala Gly Ala Thr Gly Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7606]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7606]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Glu Ala Gly Arg Ser Ala
          1 5 10 15
          Glu Ala Thr Ser Ala Gly Ala Thr Gly Pro Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7607]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7607]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ser Ala Ser Gly Thr Tyr
          1 5 10 15
          Ser Arg Gly Glu Ser Gly Pro Gly Ser Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7608]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7608]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ser Ala Ser Gly Glu Ala
          1 5 10 15
          Gly Arg Thr Asp Thr His Pro Gly Ser Pro Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7609]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7609]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ser Ala Ser Gly Glu Pro
          1 5 10 15
          Gly Arg Ala Ala Glu His Pro Gly Ser Pro Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7610]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7610]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ser Pro Ala Gly Glu Ser
          1 5 10 15
          Ser Arg Gly Thr Thr Ile Ala Gly Ser Pro Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7611]]>
           <![CDATA[ <211> 33]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7611]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Glu Ala Gly
          1 5 10 15
          Glu Ala Ala Gly Leu Thr Pro Ala Gly Leu Thr Gly Pro Pro Gly Ser
                      20 25 30
          Pro
           <![CDATA[ <210> 7612]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7612]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Glu Ala Gly Glu Ser Ala
          1 5 10 15
          Gly Ala Thr Pro Ala Gly Leu Thr Gly Pro Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7613]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7613]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ser Ala Ser Gly Ala Pro
          1 5 10 15
          Leu Glu Leu Glu Ala Gly Pro Gly Ser Pro Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7614]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7614]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ser Ala Ser Gly Glu Pro
          1 5 10 15
          Pro Glu Leu Gly Ala Gly Pro Gly Ser Pro Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7615]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7615]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ser Ala Ser Gly Glu Pro
          1 5 10 15
          Ser Gly Leu Thr Glu Gly Pro Gly Ser Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7616]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7616]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ser Ala Ser Gly Thr Pro
          1 5 10 15
          Ala Pro Leu Thr Glu Pro Pro Gly Ser Pro Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7617]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7617]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ser Ala Ser Gly Thr Pro
          1 5 10 15
          Ala Glu Leu Thr Glu Pro Pro Gly Ser Pro Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7618]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7618]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ser Ala Ser Gly Pro Pro
          1 5 10 15
          Pro Gly Leu Thr Gly Pro Pro Gly Ser Pro Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7619]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7619]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ser Ala Ser Gly Thr Pro
          1 5 10 15
          Ala Pro Leu Gly Gly Glu Pro Gly Ser Pro Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7620]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7620]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ser Pro Ala Gly Ala Pro
          1 5 10 15
          Glu Gly Leu Thr Gly Pro Ala Gly Ser Pro Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7621]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7621]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ser Pro Ala Gly Pro Pro
          1 5 10 15
          Glu Gly Leu Glu Thr Glu Ala Gly Ser Pro Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7622]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7622]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ser Pro Thr Ser Gly Gln
          1 5 10 15
          Gly Gly Leu Thr Gly Pro Gly Ser Glu Pro Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7623]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7623]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ser Glu Ser Ala Pro Pro
          1 5 10 15
          Glu Gly Leu Glu Thr Glu Ser Thr Glu Pro Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7624]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7624]]>
          Gly Thr Ala Glu Ala Ala Ser Ser Ala Ser Gly Ser Glu Gly Ser Glu Pro
          1 5 10 15
          Leu Glu Leu Gly Ala Ala Ser Glu Thr Pro Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7625]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7625]]>
          Gly Thr Ala Glu Ala Ala Ser Ser Ala Ser Ser Gly Ser Glu Gly Ser Gly Pro
          1 5 10 15
          Ala Gly Leu Glu Ala Pro Ser Glu Thr Pro Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7626]]>
           <![CDATA[ <211> 30]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 7626]]>
          Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ser Glu Pro Thr Pro Pro
          1 5 10 15
          Ala Ser Leu Glu Ala Glu Pro Gly Ser Pro Pro Gly Ser Pro
                      20 25 30
           <![CDATA[ <210> 7627]]>
           <![CDATA[ <400> 7627]]>
          000
           <![CDATA[ <210> 7628]]>
           <![CDATA[ <400> 7628]]>
          000
           <![CDATA[ <210> 7629]]>
           <![CDATA[ <400> 7629]]>
          000
           <![CDATA[ <210> 7630]]>
           <![CDATA[ <400> 7630]]>
          000
           <![CDATA[ <210> 7631]]>
           <![CDATA[ <400> 7631]]>
          000
           <![CDATA[ <210> 7632]]>
           <![CDATA[ <400> 7632]]>
          000
           <![CDATA[ <210> 7633]]>
           <![CDATA[ <400> 7633]]>
          000
           <![CDATA[ <210> 7634]]>
           <![CDATA[ <400> 7634]]>
          000
           <![CDATA[ <210> 7635]]>
           <![CDATA[ <400> 7635]]>
          000
           <![CDATA[ <210> 7636]]>
           <![CDATA[ <400> 7636]]>
          000
           <![CDATA[ <210> 7637]]>
           <![CDATA[ <400> 7637]]>
          000
           <![CDATA[ <210> 7638]]>
           <![CDATA[ <400> 7638]]>
          000
           <![CDATA[ <210> 7639]]>
           <![CDATA[ <400> 7639]]>
          000
           <![CDATA[ <210> 7640]]>
           <![CDATA[ <400> 7640]]>
          000
           <![CDATA[ <210> 7641]]>
           <![CDATA[ <400> 7641]]>
          000
           <![CDATA[ <210> 7642]]>
           <![CDATA[ <400> 7642]]>
          000
           <![CDATA[ <210> 7643]]>
           <![CDATA[ <400> 7643]]>
          000
           <![CDATA[ <210> 7644]]>
           <![CDATA[ <400> 7644]]>
          000
           <![CDATA[ <210> 7645]]>
           <![CDATA[ <400> 7645]]>
          000
           <![CDATA[ <210> 7646]]>
           <![CDATA[ <400> 7646]]>
          000
           <![CDATA[ <210> 7647]]>
           <![CDATA[ <400> 7647]]>
          000
           <![CDATA[ <210> 7648]]>
           <![CDATA[ <400> 7648]]>
          000
           <![CDATA[ <210> 7649]]>
           <![CDATA[ <400> 7649]]>
          000
           <![CDATA[ <210> 7650]]>
           <![CDATA[ <400> 7650]]>
          000
           <![CDATA[ <210> 7651]]>
           <![CDATA[ <400> 7651]]>
          000
           <![CDATA[ <210> 7652]]>
           <![CDATA[ <400> 7652]]>
          000
           <![CDATA[ <210> 7653]]>
           <![CDATA[ <400> 7653]]>
          000
           <![CDATA[ <210> 7654]]>
           <![CDATA[ <400> 7654]]>
          000
           <![CDATA[ <210> 7655]]>
           <![CDATA[ <400> 7655]]>
          000
           <![CDATA[ <210> 7656]]>
           <![CDATA[ <400> 7656]]>
          000
           <![CDATA[ <210> 7657]]>
           <![CDATA[ <400> 7657]]>
          000
           <![CDATA[ <210> 7658]]>
           <![CDATA[ <400> 7658]]>
          000
           <![CDATA[ <210> 7659]]>
           <![CDATA[ <400> 7659]]>
          000
           <![CDATA[ <210> 7660]]>
           <![CDATA[ <400> 7660]]>
          000
           <![CDATA[ <210> 7661]]>
           <![CDATA[ <400> 7661]]>
          000
           <![CDATA[ <210> 7662]]>
           <![CDATA[ <400> 7662]]>
          000
           <![CDATA[ <210> 7663]]>
           <![CDATA[ <400> 7663]]>
          000
           <![CDATA[ <210> 7664]]>
           <![CDATA[ <400> 7664]]>
          000
           <![CDATA[ <210> 7665]]>
           <![CDATA[ <400> 7665]]>
          000
           <![CDATA[ <210> 7666]]>
           <![CDATA[ <400> 7666]]>
          000
           <![CDATA[ <210> 7667]]>
           <![CDATA[ <400> 7667]]>
          000
           <![CDATA[ <210> 7668]]>
           <![CDATA[ <400> 7668]]>
          000
           <![CDATA[ <210> 7669]]>
           <![CDATA[ <400> 7669]]>
          000
           <![CDATA[ <210> 7670]]>
           <![CDATA[ <400> 7670]]>
          000
           <![CDATA[ <210> 7671]]>
           <![CDATA[ <400> 7671]]>
          000
           <![CDATA[ <210> 7672]]>
           <![CDATA[ <400> 7672]]>
          000
           <![CDATA[ <210> 7673]]>
           <![CDATA[ <400> 7673]]>
          000
           <![CDATA[ <210> 7674]]>
           <![CDATA[ <400> 7674]]>
          000
           <![CDATA[ <210> 7675]]>
           <![CDATA[ <400> 7675]]>
          000
           <![CDATA[ <210> 7676]]>
           <![CDATA[ <400> 7676]]>
          000
           <![CDATA[ <210> 7677]]>
           <![CDATA[ <400> 7677]]>
          000
           <![CDATA[ <210> 7678]]>
           <![CDATA[ <400> 7678]]>
          000
           <![CDATA[ <210> 7679]]>
           <![CDATA[ <400> 7679]]>
          000
           <![CDATA[ <210> 7680]]>
           <![CDATA[ <400> 7680]]>
          000
           <![CDATA[ <210> 7681]]>
           <![CDATA[ <400> 7681]]>
          000
           <![CDATA[ <210> 7682]]>
           <![CDATA[ <400> 7682]]>
          000
           <![CDATA[ <210> 7683]]>
           <![CDATA[ <400> 7683]]>
          000
           <![CDATA[ <210> 7684]]>
           <![CDATA[ <400> 7684]]>
          000
           <![CDATA[ <210> 7685]]>
           <![CDATA[ <400> 7685]]>
          000
           <![CDATA[ <210> 7686]]>
           <![CDATA[ <400> 7686]]>
          000
           <![CDATA[ <210> 7687]]>
           <![CDATA[ <400> 7687]]>
          000
           <![CDATA[ <210> 7688]]>
           <![CDATA[ <400> 7688]]>
          000
           <![CDATA[ <210> 7689]]>
           <![CDATA[ <400> 7689]]>
          000
           <![CDATA[ <210> 7690]]>
           <![CDATA[ <400> 7690]]>
          000
           <![CDATA[ <210> 7691]]>
           <![CDATA[ <400> 7691]]>
          000
           <![CDATA[ <210> 7692]]>
           <![CDATA[ <400> 7692]]>
          000
           <![CDATA[ <210> 7693]]>
           <![CDATA[ <400> 7693]]>
          000
           <![CDATA[ <210> 7694]]>
           <![CDATA[ <400> 7694]]>
          000
           <![CDATA[ <210> 7695]]>
           <![CDATA[ <400> 7695]]>
          000
           <![CDATA[ <210> 7696]]>
           <![CDATA[ <400> 7696]]>
          000
           <![CDATA[ <210> 7697]]>
           <![CDATA[ <400> 7697]]>
          000
           <![CDATA[ <210> 7698]]>
           <![CDATA[ <400> 7698]]>
          000
           <![CDATA[ <210> 7699]]>
           <![CDATA[ <400> 7699]]>
          000
           <![CDATA[ <210> 7700]]>
           <![CDATA[ <400> 7700]]>
          000
           <![CDATA[ <210> 7701]]>
           <![CDATA[ <400> 7701]]>
          000
           <![CDATA[ <210> 7702]]>
           <![CDATA[ <400> 7702]]>
          000
           <![CDATA[ <210> 7703]]>
           <![CDATA[ <400> 7703]]>
          000
           <![CDATA[ <210> 7704]]>
           <![CDATA[ <400> 7704]]>
          000
           <![CDATA[ <210> 7705]]>
           <![CDATA[ <400> 7705]]>
          000
           <![CDATA[ <210> 7706]]>
           <![CDATA[ <400> 7706]]>
          000
           <![CDATA[ <210> 7707]]>
           <![CDATA[ <400> 7707]]>
          000
           <![CDATA[ <210> 7708]]>
           <![CDATA[ <400> 7708]]>
          000
           <![CDATA[ <210> 7709]]>
           <![CDATA[ <400> 7709]]>
          000
           <![CDATA[ <210> 7710]]>
           <![CDATA[ <400> 7710]]>
          000
           <![CDATA[ <210> 7711]]>
           <![CDATA[ <400> 7711]]>
          000
           <![CDATA[ <210> 7712]]>
           <![CDATA[ <400> 7712]]>
          000
           <![CDATA[ <210> 7713]]>
           <![CDATA[ <400> 7713]]>
          000
           <![CDATA[ <210> 7714]]>
           <![CDATA[ <400> 7714]]>
          000
           <![CDATA[ <210> 7715]]>
           <![CDATA[ <400> 7715]]>
          000
           <![CDATA[ <210> 7716]]>
           <![CDATA[ <400> 7716]]>
          000
           <![CDATA[ <210> 7717]]>
           <![CDATA[ <400> 7717]]>
          000
           <![CDATA[ <210> 7718]]>
           <![CDATA[ <400> 7718]]>
          000
           <![CDATA[ <210> 7719]]>
           <![CDATA[ <400> 7719]]>
          000
           <![CDATA[ <210> 7720]]>
           <![CDATA[ <400> 7720]]>
          000
           <![CDATA[ <210> 7721]]>
           <![CDATA[ <400> 7721]]>
          000
           <![CDATA[ <210> 7722]]>
           <![CDATA[ <400> 7722]]>
          000
           <![CDATA[ <210> 7723]]>
           <![CDATA[ <400> 7723]]>
          000
           <![CDATA[ <210> 7724]]>
           <![CDATA[ <400> 7724]]>
          000
           <![CDATA[ <210> 7725]]>
           <![CDATA[ <400> 7725]]>
          000
           <![CDATA[ <210> 7726]]>
           <![CDATA[ <400> 7726]]>
          000
           <![CDATA[ <210> 7727]]>
           <![CDATA[ <400> 7727]]>
          000
           <![CDATA[ <210> 7728]]>
           <![CDATA[ <400> 7728]]>
          000
           <![CDATA[ <210> 7729]]>
           <![CDATA[ <400> 7729]]>
          000
           <![CDATA[ <210> 7730]]>
           <![CDATA[ <400> 7730]]>
          000
           <![CDATA[ <210> 7731]]>
           <![CDATA[ <400> 7731]]>
          000
           <![CDATA[ <210> 7732]]>
           <![CDATA[ <400> 7732]]>
          000
           <![CDATA[ <210> 7733]]>
           <![CDATA[ <400> 7733]]>
          000
           <![CDATA[ <210> 7734]]>
           <![CDATA[ <400> 7734]]>
          000
           <![CDATA[ <210> 7735]]>
           <![CDATA[ <400> 7735]]>
          000
           <![CDATA[ <210> 7736]]>
           <![CDATA[ <400> 7736]]>
          000
           <![CDATA[ <210> 7737]]>
           <![CDATA[ <400> 7737]]>
          000
           <![CDATA[ <210> 7738]]>
           <![CDATA[ <400> 7738]]>
          000
           <![CDATA[ <210> 7739]]>
           <![CDATA[ <400> 7739]]>
          000
           <![CDATA[ <210> 7740]]>
           <![CDATA[ <400> 7740]]>
          000
           <![CDATA[ <210> 7741]]>
           <![CDATA[ <400> 7741]]>
          000
           <![CDATA[ <210> 7742]]>
           <![CDATA[ <400> 7742]]>
          000
           <![CDATA[ <210> 7743]]>
           <![CDATA[ <400> 7743]]>
          000
           <![CDATA[ <210> 7744]]>
           <![CDATA[ <400> 7744]]>
          000
           <![CDATA[ <210> 7745]]>
           <![CDATA[ <400> 7745]]>
          000
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           <![CDATA[ <400> 7746]]>
          000
           <![CDATA[ <210> 7747]]>
           <![CDATA[ <400> 7747]]>
          000
           <![CDATA[ <210> 7748]]>
           <![CDATA[ <400> 7748]]>
          000
           <![CDATA[ <210> 7749]]>
           <![CDATA[ <400> 7749]]>
          000
           <![CDATA[ <210> 7750]]>
           <![CDATA[ <400> 7750]]>
          000
           <![CDATA[ <210> 7751]]>
           <![CDATA[ <400> 7751]]>
          000
           <![CDATA[ <210> 7752]]>
           <![CDATA[ <400> 7752]]>
          000
           <![CDATA[ <210> 7753]]>
           <![CDATA[ <400> 7753]]>
          000
           <![CDATA[ <210> 7754]]>
           <![CDATA[ <400> 7754]]>
          000
           <![CDATA[ <210> 7755]]>
           <![CDATA[ <400> 7755]]>
          000
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           <![CDATA[ <400> 7756]]>
          000
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           <![CDATA[ <400> 7757]]>
          000
           <![CDATA[ <210> 7758]]>
           <![CDATA[ <400> 7758]]>
          000
           <![CDATA[ <210> 7759]]>
           <![CDATA[ <400> 7759]]>
          000
           <![CDATA[ <210> 7760]]>
           <![CDATA[ <400> 7760]]>
          000
           <![CDATA[ <210> 7761]]>
           <![CDATA[ <400> 7761]]>
          000
           <![CDATA[ <210> 7762]]>
           <![CDATA[ <400> 7762]]>
          000
           <![CDATA[ <210> 7763]]>
           <![CDATA[ <400> 7763]]>
          000
           <![CDATA[ <210> 7764]]>
           <![CDATA[ <400> 7764]]>
          000
           <![CDATA[ <210> 7765]]>
           <![CDATA[ <400> 7765]]>
          000
           <![CDATA[ <210> 7766]]>
           <![CDATA[ <400> 7766]]>
          000
           <![CDATA[ <210> 7767]]>
           <![CDATA[ <400> 7767]]>
          000
           <![CDATA[ <210> 7768]]>
           <![CDATA[ <400> 7768]]>
          000
           <![CDATA[ <210> 7769]]>
           <![CDATA[ <400> 7769]]>
          000
           <![CDATA[ <210> 7770]]>
           <![CDATA[ <400> 7770]]>
          000
           <![CDATA[ <210> 7771]]>
           <![CDATA[ <400> 7771]]>
          000
           <![CDATA[ <210> 7772]]>
           <![CDATA[ <400> 7772]]>
          000
           <![CDATA[ <210> 7773]]>
           <![CDATA[ <400> 7773]]>
          000
           <![CDATA[ <210> 7774]]>
           <![CDATA[ <400> 7774]]>
          000
           <![CDATA[ <210> 7775]]>
           <![CDATA[ <400> 7775]]>
          000
           <![CDATA[ <210> 7776]]>
           <![CDATA[ <400> 7776]]>
          000
           <![CDATA[ <210> 7777]]>
           <![CDATA[ <400> 7777]]>
          000
           <![CDATA[ <210> 7778]]>
           <![CDATA[ <400> 7778]]>
          000
           <![CDATA[ <210> 7779]]>
           <![CDATA[ <400> 7779]]>
          000
           <![CDATA[ <210> 7780]]>
           <![CDATA[ <400> 7780]]>
          000
           <![CDATA[ <210> 7781]]>
           <![CDATA[ <400> 7781]]>
          000
           <![CDATA[ <210> 7782]]>
           <![CDATA[ <400> 7782]]>
          000
           <![CDATA[ <210> 7783]]>
           <![CDATA[ <400> 7783]]>
          000
           <![CDATA[ <210> 7784]]>
           <![CDATA[ <400> 7784]]>
          000
           <![CDATA[ <210> 7785]]>
           <![CDATA[ <400> 7785]]>
          000
           <![CDATA[ <210> 7786]]>
           <![CDATA[ <400> 7786]]>
          000
           <![CDATA[ <210> 7787]]>
           <![CDATA[ <400> 7787]]>
          000
           <![CDATA[ <210> 7788]]>
           <![CDATA[ <400> 7788]]>
          000
           <![CDATA[ <210> 7789]]>
           <![CDATA[ <400> 7789]]>
          000
           <![CDATA[ <210> 7790]]>
           <![CDATA[ <400> 7790]]>
          000
           <![CDATA[ <210> 7791]]>
           <![CDATA[ <400> 7791]]>
          000
           <![CDATA[ <210> 7792]]>
           <![CDATA[ <400> 7792]]>
          000
           <![CDATA[ <210> 7793]]>
           <![CDATA[ <400> 7793]]>
          000
           <![CDATA[ <210> 7794]]>
           <![CDATA[ <400> 7794]]>
          000
           <![CDATA[ <210> 7795]]>
           <![CDATA[ <400> 7795]]>
          000
           <![CDATA[ <210> 7796]]>
           <![CDATA[ <400> 7796]]>
          000
           <![CDATA[ <210> 7797]]>
           <![CDATA[ <400> 7797]]>
          000
           <![CDATA[ <210> 7798]]>
           <![CDATA[ <400> 7798]]>
          000
           <![CDATA[ <210> 7799]]>
           <![CDATA[ <400> 7799]]>
          000
           <![CDATA[ <210> 7800]]>
           <![CDATA[ <400> 7800]]>
          000
           <![CDATA[ <210> 7801]]>
           <![CDATA[ <400> 7801]]>
          000
           <![CDATA[ <210> 7802]]>
           <![CDATA[ <400> 7802]]>
          000
           <![CDATA[ <210> 7803]]>
           <![CDATA[ <400> 7803]]>
          000
           <![CDATA[ <210> 7804]]>
           <![CDATA[ <400> 7804]]>
          000
           <![CDATA[ <210> 7805]]>
           <![CDATA[ <400> 7805]]>
          000
           <![CDATA[ <210> 7806]]>
           <![CDATA[ <400> 7806]]>
          000
           <![CDATA[ <210> 7807]]>
           <![CDATA[ <400> 7807]]>
          000
           <![CDATA[ <210> 7808]]>
           <![CDATA[ <400> 7808]]>
          000
           <![CDATA[ <210> 7809]]>
           <![CDATA[ <400> 7809]]>
          000
           <![CDATA[ <210> 7810]]>
           <![CDATA[ <400> 7810]]>
          000
           <![CDATA[ <210> 7811]]>
           <![CDATA[ <400> 7811]]>
          000
           <![CDATA[ <210> 7812]]>
           <![CDATA[ <400> 7812]]>
          000
           <![CDATA[ <210> 7813]]>
           <![CDATA[ <400> 7813]]>
          000
           <![CDATA[ <210> 7814]]>
           <![CDATA[ <400> 7814]]>
          000
           <![CDATA[ <210> 7815]]>
           <![CDATA[ <400> 7815]]>
          000
           <![CDATA[ <210> 7816]]>
           <![CDATA[ <400> 7816]]>
          000
           <![CDATA[ <210> 7817]]>
           <![CDATA[ <400> 7817]]>
          000
           <![CDATA[ <210> 7818]]>
           <![CDATA[ <400> 7818]]>
          000
           <![CDATA[ <210> 7819]]>
           <![CDATA[ <400> 7819]]>
          000
           <![CDATA[ <210> 7820]]>
           <![CDATA[ <400> 7820]]>
          000
           <![CDATA[ <210> 7821]]>
           <![CDATA[ <400> 7821]]>
          000
           <![CDATA[ <210> 7822]]>
           <![CDATA[ <400> 7822]]>
          000
           <![CDATA[ <210> 7823]]>
           <![CDATA[ <400> 7823]]>
          000
           <![CDATA[ <210> 7824]]>
           <![CDATA[ <400> 7824]]>
          000
           <![CDATA[ <210> 7825]]>
           <![CDATA[ <400> 7825]]>
          000
           <![CDATA[ <210> 7826]]>
           <![CDATA[ <400> 7826]]>
          000
           <![CDATA[ <210> 7827]]>
           <![CDATA[ <400> 7827]]>
          000
           <![CDATA[ <210> 7828]]>
           <![CDATA[ <400> 7828]]>
          000
           <![CDATA[ <210> 7829]]>
           <![CDATA[ <400> 7829]]>
          000
           <![CDATA[ <210> 7830]]>
           <![CDATA[ <400> 7830]]>
          000
           <![CDATA[ <210> 7831]]>
           <![CDATA[ <400> 7831]]>
          000
           <![CDATA[ <210> 7832]]>
           <![CDATA[ <400> 7832]]>
          000
           <![CDATA[ <210> 7833]]>
           <![CDATA[ <400> 7833]]>
          000
           <![CDATA[ <210> 7834]]>
           <![CDATA[ <400> 7834]]>
          000
           <![CDATA[ <210> 7835]]>
           <![CDATA[ <400> 7835]]>
          000
           <![CDATA[ <210> 7836]]>
           <![CDATA[ <400> 7836]]>
          000
           <![CDATA[ <210> 7837]]>
           <![CDATA[ <400> 7837]]>
          000
           <![CDATA[ <210> 7838]]>
           <![CDATA[ <400> 7838]]>
          000
           <![CDATA[ <210> 7839]]>
           <![CDATA[ <400> 7839]]>
          000
           <![CDATA[ <210> 7840]]>
           <![CDATA[ <400> 7840]]>
          000
           <![CDATA[ <210> 7841]]>
           <![CDATA[ <400> 7841]]>
          000
           <![CDATA[ <210> 7842]]>
           <![CDATA[ <400> 7842]]>
          000
           <![CDATA[ <210> 7843]]>
           <![CDATA[ <400> 7843]]>
          000
           <![CDATA[ <210> 7844]]>
           <![CDATA[ <400> 7844]]>
          000
           <![CDATA[ <210> 7845]]>
           <![CDATA[ <400> 7845]]>
          000
           <![CDATA[ <210> 7846]]>
           <![CDATA[ <400> 7846]]>
          000
           <![CDATA[ <210> 7847]]>
           <![CDATA[ <400> 7847]]>
          000
           <![CDATA[ <210> 7848]]>
           <![CDATA[ <400> 7848]]>
          000
           <![CDATA[ <210> 7849]]>
           <![CDATA[ <400> 7849]]>
          000
           <![CDATA[ <210> 7850]]>
           <![CDATA[ <400> 7850]]>
          000
           <![CDATA[ <210> 7851]]>
           <![CDATA[ <400> 7851]]>
          000
           <![CDATA[ <210> 7852]]>
           <![CDATA[ <400> 7852]]>
          000
           <![CDATA[ <210> 7853]]>
           <![CDATA[ <400> 7853]]>
          000
           <![CDATA[ <210> 7854]]>
           <![CDATA[ <400> 7854]]>
          000
           <![CDATA[ <210> 7855]]>
           <![CDATA[ <400> 7855]]>
          000
           <![CDATA[ <210> 7856]]>
           <![CDATA[ <400> 7856]]>
          000
           <![CDATA[ <210> 7857]]>
           <![CDATA[ <400> 7857]]>
          000
           <![CDATA[ <210> 7858]]>
           <![CDATA[ <400> 7858]]>
          000
           <![CDATA[ <210> 7859]]>
           <![CDATA[ <400> 7859]]>
          000
           <![CDATA[ <210> 7860]]>
           <![CDATA[ <400> 7860]]>
          000
           <![CDATA[ <210> 7861]]>
           <![CDATA[ <400> 7861]]>
          000
           <![CDATA[ <210> 7862]]>
           <![CDATA[ <400> 7862]]>
          000
           <![CDATA[ <210> 7863]]>
           <![CDATA[ <400> 7863]]>
          000
           <![CDATA[ <210> 7864]]>
           <![CDATA[ <400> 7864]]>
          000
           <![CDATA[ <210> 7865]]>
           <![CDATA[ <400> 7865]]>
          000
           <![CDATA[ <210> 7866]]>
           <![CDATA[ <400> 7866]]>
          000
           <![CDATA[ <210> 7867]]>
           <![CDATA[ <400> 7867]]>
          000
           <![CDATA[ <210> 7868]]>
           <![CDATA[ <400> 7868]]>
          000
           <![CDATA[ <210> 7869]]>
           <![CDATA[ <400> 7869]]>
          000
           <![CDATA[ <210> 7870]]>
           <![CDATA[ <400> 7870]]>
          000
           <![CDATA[ <210> 7871]]>
           <![CDATA[ <400> 7871]]>
          000
           <![CDATA[ <210> 7872]]>
           <![CDATA[ <400> 7872]]>
          000
           <![CDATA[ <210> 7873]]>
           <![CDATA[ <400> 7873]]>
          000
           <![CDATA[ <210> 7874]]>
           <![CDATA[ <400> 7874]]>
          000
           <![CDATA[ <210> 7875]]>
           <![CDATA[ <400> 7875]]>
          000
           <![CDATA[ <210> 7876]]>
           <![CDATA[ <400> 7876]]>
          000
           <![CDATA[ <210> 7877]]>
           <![CDATA[ <400> 7877]]>
          000
           <![CDATA[ <210> 7878]]>
           <![CDATA[ <400> 7878]]>
          000
           <![CDATA[ <210> 7879]]>
           <![CDATA[ <400> 7879]]>
          000
           <![CDATA[ <210> 7880]]>
           <![CDATA[ <400> 7880]]>
          000
           <![CDATA[ <210> 7881]]>
           <![CDATA[ <400> 7881]]>
          000
           <![CDATA[ <210> 7882]]>
           <![CDATA[ <400> 7882]]>
          000
           <![CDATA[ <210> 7883]]>
           <![CDATA[ <400> 7883]]>
          000
           <![CDATA[ <210> 7884]]>
           <![CDATA[ <400> 7884]]>
          000
           <![CDATA[ <210> 7885]]>
           <![CDATA[ <400> 7885]]>
          000
           <![CDATA[ <210> 7886]]>
           <![CDATA[ <400> 7886]]>
          000
           <![CDATA[ <210> 7887]]>
           <![CDATA[ <400> 7887]]>
          000
           <![CDATA[ <210> 7888]]>
           <![CDATA[ <400> 7888]]>
          000
           <![CDATA[ <210> 7889]]>
           <![CDATA[ <400> 7889]]>
          000
           <![CDATA[ <210> 7890]]>
           <![CDATA[ <400> 7890]]>
          000
           <![CDATA[ <210> 7891]]>
           <![CDATA[ <400> 7891]]>
          000
           <![CDATA[ <210> 7892]]>
           <![CDATA[ <400> 7892]]>
          000
           <![CDATA[ <210> 7893]]>
           <![CDATA[ <400> 7893]]>
          000
           <![CDATA[ <210> 7894]]>
           <![CDATA[ <400> 7894]]>
          000
           <![CDATA[ <210> 7895]]>
           <![CDATA[ <400> 7895]]>
          000
           <![CDATA[ <210> 7896]]>
           <![CDATA[ <400> 7896]]>
          000
           <![CDATA[ <210> 7897]]>
           <![CDATA[ <400> 7897]]>
          000
           <![CDATA[ <210> 7898]]>
           <![CDATA[ <400> 7898]]>
          000
           <![CDATA[ <210> 7899]]>
           <![CDATA[ <400> 7899]]>
          000
           <![CDATA[ <210> 7900]]>
           <![CDATA[ <400> 7900]]>
          000
           <![CDATA[ <210> 7901]]>
           <![CDATA[ <400> 7901]]>
          000
           <![CDATA[ <210> 7902]]>
           <![CDATA[ <400> 7902]]>
          000
           <![CDATA[ <210> 7903]]>
           <![CDATA[ <400> 7903]]>
          000
           <![CDATA[ <210> 7904]]>
           <![CDATA[ <400> 7904]]>
          000
           <![CDATA[ <210> 7905]]>
           <![CDATA[ <400> 7905]]>
          000
           <![CDATA[ <210> 7906]]>
           <![CDATA[ <400> 7906]]>
          000
           <![CDATA[ <210> 7907]]>
           <![CDATA[ <400> 7907]]>
          000
           <![CDATA[ <210> 7908]]>
           <![CDATA[ <400> 7908]]>
          000
           <![CDATA[ <210> 7909]]>
           <![CDATA[ <400> 7909]]>
          000
           <![CDATA[ <210> 7910]]>
           <![CDATA[ <400> 7910]]>
          000
           <![CDATA[ <210> 7911]]>
           <![CDATA[ <400> 7911]]>
          000
           <![CDATA[ <210> 7912]]>
           <![CDATA[ <400> 7912]]>
          000
           <![CDATA[ <210> 7913]]>
           <![CDATA[ <400> 7913]]>
          000
           <![CDATA[ <210> 7914]]>
           <![CDATA[ <400> 7914]]>
          000
           <![CDATA[ <210> 7915]]>
           <![CDATA[ <400> 7915]]>
          000
           <![CDATA[ <210> 7916]]>
           <![CDATA[ <400> 7916]]>
          000
           <![CDATA[ <210> 7917]]>
           <![CDATA[ <400> 7917]]>
          000
           <![CDATA[ <210> 7918]]>
           <![CDATA[ <400> 7918]]>
          000
           <![CDATA[ <210> 7919]]>
           <![CDATA[ <400> 7919]]>
          000
           <![CDATA[ <210> 7920]]>
           <![CDATA[ <400> 7920]]>
          000
           <![CDATA[ <210> 7921]]>
           <![CDATA[ <400> 7921]]>
          000
           <![CDATA[ <210> 7922]]>
           <![CDATA[ <400> 7922]]>
          000
           <![CDATA[ <210> 7923]]>
           <![CDATA[ <400> 7923]]>
          000
           <![CDATA[ <210> 7924]]>
           <![CDATA[ <400> 7924]]>
          000
           <![CDATA[ <210> 7925]]>
           <![CDATA[ <400> 7925]]>
          000
           <![CDATA[ <210> 7926]]>
           <![CDATA[ <400> 7926]]>
          000
           <![CDATA[ <210> 7927]]>
           <![CDATA[ <400> 7927]]>
          000
           <![CDATA[ <210> 7928]]>
           <![CDATA[ <400> 7928]]>
          000
           <![CDATA[ <210> 7929]]>
           <![CDATA[ <400> 7929]]>
          000
           <![CDATA[ <210> 7930]]>
           <![CDATA[ <400> 7930]]>
          000
           <![CDATA[ <210> 7931]]>
           <![CDATA[ <400> 7931]]>
          000
           <![CDATA[ <210> 7932]]>
           <![CDATA[ <400> 7932]]>
          000
           <![CDATA[ <210> 7933]]>
           <![CDATA[ <400> 7933]]>
          000
           <![CDATA[ <210> 7934]]>
           <![CDATA[ <400> 7934]]>
          000
           <![CDATA[ <210> 7935]]>
           <![CDATA[ <400> 7935]]>
          000
           <![CDATA[ <210> 7936]]>
           <![CDATA[ <400> 7936]]>
          000
           <![CDATA[ <210> 7937]]>
           <![CDATA[ <400> 7937]]>
          000
           <![CDATA[ <210> 7938]]>
           <![CDATA[ <400> 7938]]>
          000
           <![CDATA[ <210> 7939]]>
           <![CDATA[ <400> 7939]]>
          000
           <![CDATA[ <210> 7940]]>
           <![CDATA[ <400> 7940]]>
          000
           <![CDATA[ <210> 7941]]>
           <![CDATA[ <400> 7941]]>
          000
           <![CDATA[ <210> 7942]]>
           <![CDATA[ <400> 7942]]>
          000
           <![CDATA[ <210> 7943]]>
           <![CDATA[ <400> 7943]]>
          000
           <![CDATA[ <210> 7944]]>
           <![CDATA[ <400> 7944]]>
          000
           <![CDATA[ <210> 7945]]>
           <![CDATA[ <400> 7945]]>
          000
           <![CDATA[ <210> 7946]]>
           <![CDATA[ <400> 7946]]>
          000
           <![CDATA[ <210> 7947]]>
           <![CDATA[ <400> 7947]]>
          000
           <![CDATA[ <210> 7948]]>
           <![CDATA[ <400> 7948]]>
          000
           <![CDATA[ <210> 7949]]>
           <![CDATA[ <400> 7949]]>
          000
           <![CDATA[ <210> 7950]]>
           <![CDATA[ <400> 7950]]>
          000
           <![CDATA[ <210> 7951]]>
           <![CDATA[ <400> 7951]]>
          000
           <![CDATA[ <210> 7952]]>
           <![CDATA[ <400> 7952]]>
          000
           <![CDATA[ <210> 7953]]>
           <![CDATA[ <400> 7953]]>
          000
           <![CDATA[ <210> 7954]]>
           <![CDATA[ <400> 7954]]>
          000
           <![CDATA[ <210> 7955]]>
           <![CDATA[ <400> 7955]]>
          000
           <![CDATA[ <210> 7956]]>
           <![CDATA[ <400> 7956]]>
          000
           <![CDATA[ <210> 7957]]>
           <![CDATA[ <400> 7957]]>
          000
           <![CDATA[ <210> 7958]]>
           <![CDATA[ <400> 7958]]>
          000
           <![CDATA[ <210> 7959]]>
           <![CDATA[ <400> 7959]]>
          000
           <![CDATA[ <210> 7960]]>
           <![CDATA[ <400> 7960]]>
          000
           <![CDATA[ <210> 7961]]>
           <![CDATA[ <400> 7961]]>
          000
           <![CDATA[ <210> 7962]]>
           <![CDATA[ <400> 7962]]>
          000
           <![CDATA[ <210> 7963]]>
           <![CDATA[ <400> 7963]]>
          000
           <![CDATA[ <210> 7964]]>
           <![CDATA[ <400> 7964]]>
          000
           <![CDATA[ <210> 7965]]>
           <![CDATA[ <400> 7965]]>
          000
           <![CDATA[ <210> 7966]]>
           <![CDATA[ <400> 7966]]>
          000
           <![CDATA[ <210> 7967]]>
           <![CDATA[ <400> 7967]]>
          000
           <![CDATA[ <210> 7968]]>
           <![CDATA[ <400> 7968]]>
          000
           <![CDATA[ <210> 7969]]>
           <![CDATA[ <400> 7969]]>
          000
           <![CDATA[ <210> 7970]]>
           <![CDATA[ <400> 7970]]>
          000
           <![CDATA[ <210> 7971]]>
           <![CDATA[ <400> 7971]]>
          000
           <![CDATA[ <210> 7972]]>
           <![CDATA[ <400> 7972]]>
          000
           <![CDATA[ <210> 7973]]>
           <![CDATA[ <400> 7973]]>
          000
           <![CDATA[ <210> 7974]]>
           <![CDATA[ <400> 7974]]>
          000
           <![CDATA[ <210> 7975]]>
           <![CDATA[ <400> 7975]]>
          000
           <![CDATA[ <210> 7976]]>
           <![CDATA[ <400> 7976]]>
          000
           <![CDATA[ <210> 7977]]>
           <![CDATA[ <400> 7977]]>
          000
           <![CDATA[ <210> 7978]]>
           <![CDATA[ <400> 7978]]>
          000
           <![CDATA[ <210> 7979]]>
           <![CDATA[ <400> 7979]]>
          000
           <![CDATA[ <210> 7980]]>
           <![CDATA[ <400> 7980]]>
          000
           <![CDATA[ <210> 7981]]>
           <![CDATA[ <400> 7981]]>
          000
           <![CDATA[ <210> 7982]]>
           <![CDATA[ <400> 7982]]>
          000
           <![CDATA[ <210> 7983]]>
           <![CDATA[ <400> 7983]]>
          000
           <![CDATA[ <210> 7984]]>
           <![CDATA[ <400> 7984]]>
          000
           <![CDATA[ <210> 7985]]>
           <![CDATA[ <400> 7985]]>
          000
           <![CDATA[ <210> 7986]]>
           <![CDATA[ <400> 7986]]>
          000
           <![CDATA[ <210> 7987]]>
           <![CDATA[ <400> 7987]]>
          000
           <![CDATA[ <210> 7988]]>
           <![CDATA[ <400> 7988]]>
          000
           <![CDATA[ <210> 7989]]>
           <![CDATA[ <400> 7989]]>
          000
           <![CDATA[ <210> 7990]]>
           <![CDATA[ <400> 7990]]>
          000
           <![CDATA[ <210> 7991]]>
           <![CDATA[ <400> 7991]]>
          000
           <![CDATA[ <210> 7992]]>
           <![CDATA[ <400> 7992]]>
          000
           <![CDATA[ <210> 7993]]>
           <![CDATA[ <400> 7993]]>
          000
           <![CDATA[ <210> 7994]]>
           <![CDATA[ <400> 7994]]>
          000
           <![CDATA[ <210> 7995]]>
           <![CDATA[ <400> 7995]]>
          000
           <![CDATA[ <210> 7996]]>
           <![CDATA[ <400> 7996]]>
          000
           <![CDATA[ <210> 7997]]>
           <![CDATA[ <400> 7997]]>
          000
           <![CDATA[ <210> 7998]]>
           <![CDATA[ <400> 7998]]>
          000
           <![CDATA[ <210> 7999]]>
           <![CDATA[ <400> 7999]]>
          000
           <![CDATA[ <210> 8000]]>
           <![CDATA[ <400> 8000]]>
          000
           <![CDATA[ <210> 8001]]>
           <![CDATA[ <211> 874]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 8001]]>
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
          1 5 10 15
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
                      20 25 30
          Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
                  35 40 45
          Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
              50 55 60
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
          65 70 75 80
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
                          85 90 95
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro
                      100 105 110
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
                  115 120 125
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
              130 135 140
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro
          145 150 155 160
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser
                          165 170 175
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                      180 185 190
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                  195 200 205
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
              210 215 220
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
          225 230 235 240
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                          245 250 255
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
                      260 265 270
          Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  275 280 285
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
              290 295 300
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
          305 310 315 320
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                          325 330 335
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                      340 345 350
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser
                  355 360 365
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
              370 375 380
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
          385 390 395 400
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro
                          405 410 415
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
                      420 425 430
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu
                  435 440 445
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr
              450 455 460
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
          465 470 475 480
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                          485 490 495
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
                      500 505 510
          Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
                  515 520 525
          Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro
              530 535 540
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
          545 550 555 560
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                          565 570 575
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu
                      580 585 590
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr
                  595 600 605
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
              610 615 620
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
          625 630 635 640
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro
                          645 650 655
          Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                      660 665 670
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
                  675 680 685
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro
              690 695 700
          Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
          705 710 715 720
          Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                          725 730 735
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr
                      740 745 750
          Pro Glu Ser Gly Pro Gly Phe Thr Ala Asx Thr Ser Glu Ser Ala Thr
                  755 760 765
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Pro Thr Glu
              770 775 780
          Ser Gly Ser Glu Pro Ala Thr Ser Ser Gly Ser Glu Thr Pro Gly Ser Pro
          785 790 795 800
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser
                          805 810 815
          Glu Gly Ser Ala Pro Gly Thr Glu Ser Thr Pro Ser Glu Gly Ser Ala
                      820 825 830
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
                  835 840 845
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
              850 855 860
          Glu Gly Ser Ala Pro Gly Glu Pro Glu Ala
          865 870
           <![CDATA[ <210> 8002]]>
           <![CDATA[ <211> 870]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 8002]]>
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
          1 5 10 15
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
                      20 25 30
          Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
                  35 40 45
          Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
              50 55 60
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
          65 70 75 80
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
                          85 90 95
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro
                      100 105 110
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
                  115 120 125
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
              130 135 140
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro
          145 150 155 160
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser
                          165 170 175
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                      180 185 190
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                  195 200 205
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
              210 215 220
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
          225 230 235 240
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                          245 250 255
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
                      260 265 270
          Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  275 280 285
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
              290 295 300
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
          305 310 315 320
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                          325 330 335
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                      340 345 350
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser
                  355 360 365
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
              370 375 380
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
          385 390 395 400
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro
                          405 410 415
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
                      420 425 430
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu
                  435 440 445
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr
              450 455 460
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
          465 470 475 480
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                          485 490 495
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
                      500 505 510
          Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
                  515 520 525
          Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro
              530 535 540
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
          545 550 555 560
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                          565 570 575
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu
                      580 585 590
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr
                  595 600 605
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
              610 615 620
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
          625 630 635 640
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro
                          645 650 655
          Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                      660 665 670
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
                  675 680 685
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro
              690 695 700
          Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
          705 710 715 720
          Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                          725 730 735
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr
                      740 745 750
          Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  755 760 765
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Pro Thr Glu Ser Gly Ser Glu
              770 775 780
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro
          785 790 795 800
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
                          805 810 815
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu
                      820 825 830
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr
                  835 840 845
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
              850 855 860
          Pro Gly Glu Pro Glu Ala
          865 870
           <![CDATA[ <210> 8003]]>
           <![CDATA[ <211> 870]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 8003]]>
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
          1 5 10 15
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
                      20 25 30
          Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
                  35 40 45
          Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
              50 55 60
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
          65 70 75 80
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
                          85 90 95
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro
                      100 105 110
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
                  115 120 125
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
              130 135 140
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro
          145 150 155 160
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser
                          165 170 175
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                      180 185 190
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                  195 200 205
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
              210 215 220
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
          225 230 235 240
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                          245 250 255
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
                      260 265 270
          Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  275 280 285
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
              290 295 300
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
          305 310 315 320
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                          325 330 335
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                      340 345 350
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser
                  355 360 365
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
              370 375 380
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
          385 390 395 400
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro
                          405 410 415
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
                      420 425 430
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu
                  435 440 445
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr
              450 455 460
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
          465 470 475 480
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                          485 490 495
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
                      500 505 510
          Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
                  515 520 525
          Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro
              530 535 540
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
          545 550 555 560
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                          565 570 575
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu
                      580 585 590
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr
                  595 600 605
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
              610 615 620
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
          625 630 635 640
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro
                          645 650 655
          Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                      660 665 670
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
                  675 680 685
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro
              690 695 700
          Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
          705 710 715 720
          Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                          725 730 735
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr
                      740 745 750
          Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  755 760 765
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu
              770 775 780
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro
          785 790 795 800
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
                          805 810 815
          Pro Gly Thr Glu Ser Thr Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu
                      820 825 830
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr
                  835 840 845
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
              850 855 860
          Pro Gly Glu Pro Glu Ala
          865 870
           <![CDATA[ <210> 8004]]>
           <![CDATA[ <211> 294]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 8004]]>
          Ala Ser Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Ser Gly Thr Ser
          1 5 10 15
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Glu Thr Glu Pro Ser
                      20 25 30
          Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  35 40 45
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
              50 55 60
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Thr Pro Ala Glu Ser
          65 70 75 80
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                          85 90 95
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro
                      100 105 110
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
                  115 120 125
          Pro Glu Ser Gly Pro Gly Glu Ser Pro Ala Thr Ser Gly Ser Thr Pro
              130 135 140
          Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro
          145 150 155 160
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro
                          165 170 175
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
                      180 185 190
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                  195 200 205
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr
              210 215 220
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
          225 230 235 240
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro
                          245 250 255
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser
                      260 265 270
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                  275 280 285
          Pro Gly Gly Ser Ala Pro
              290
           <![CDATA[ <210> 8005]]>
           <![CDATA[ <211> 294]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 8005]]>
          Ala Ser Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Ser Gly Thr Ser
          1 5 10 15
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
                      20 25 30
          Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  35 40 45
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
              50 55 60
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
          65 70 75 80
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                          85 90 95
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro
                      100 105 110
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
                  115 120 125
          Pro Glu Ser Gly Pro Gly Glu Ser Pro Ala Thr Ser Gly Ser Thr Pro
              130 135 140
          Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro
          145 150 155 160
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro
                          165 170 175
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
                      180 185 190
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                  195 200 205
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr
              210 215 220
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
          225 230 235 240
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro
                          245 250 255
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser
                      260 265 270
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                  275 280 285
          Pro Gly Gly Ser Ala Pro
              290
           <![CDATA[ <210> 8006]]>
           <![CDATA[ <211> 294]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 8006]]>
          Ala Ser Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Ser Gly Thr Ser
          1 5 10 15
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
                      20 25 30
          Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  35 40 45
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
              50 55 60
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Thr Pro Ala Glu Ser
          65 70 75 80
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                          85 90 95
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro
                      100 105 110
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
                  115 120 125
          Pro Glu Ser Gly Pro Gly Glu Glu Pro Ala Thr Ser Gly Ser Thr Pro
              130 135 140
          Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro
          145 150 155 160
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro
                          165 170 175
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
                      180 185 190
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                  195 200 205
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr
              210 215 220
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
          225 230 235 240
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro
                          245 250 255
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser
                      260 265 270
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                  275 280 285
          Pro Gly Gly Ser Ala Pro
              290
           <![CDATA[ <210> 8007]]>
           <![CDATA[ <211> 294]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 8007]]>
          Ala Ser Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Ser Gly Thr Ser
          1 5 10 15
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
                      20 25 30
          Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  35 40 45
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
              50 55 60
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Thr Pro Ala Glu Ser
          65 70 75 80
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                          85 90 95
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro
                      100 105 110
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
                  115 120 125
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
              130 135 140
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro
          145 150 155 160
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro
                          165 170 175
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
                      180 185 190
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                  195 200 205
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr
              210 215 220
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
          225 230 235 240
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro
                          245 250 255
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser
                      260 265 270
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                  275 280 285
          Pro Gly Gly Ser Ala Pro
              290
           <![CDATA[ <210> 8008]]>
           <![CDATA[ <211> 866]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 8008]]>
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
          1 5 10 15
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
                      20 25 30
          Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
                  35 40 45
          Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
              50 55 60
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
          65 70 75 80
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
                          85 90 95
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro
                      100 105 110
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
                  115 120 125
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
              130 135 140
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro
          145 150 155 160
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser
                          165 170 175
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                      180 185 190
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                  195 200 205
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
              210 215 220
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
          225 230 235 240
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                          245 250 255
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
                      260 265 270
          Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  275 280 285
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
              290 295 300
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
          305 310 315 320
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                          325 330 335
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                      340 345 350
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser
                  355 360 365
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
              370 375 380
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
          385 390 395 400
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro
                          405 410 415
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
                      420 425 430
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu
                  435 440 445
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr
              450 455 460
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
          465 470 475 480
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                          485 490 495
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
                      500 505 510
          Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
                  515 520 525
          Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro
              530 535 540
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
          545 550 555 560
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                          565 570 575
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu
                      580 585 590
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr
                  595 600 605
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
              610 615 620
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
          625 630 635 640
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro
                          645 650 655
          Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                      660 665 670
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
                  675 680 685
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro
              690 695 700
          Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
          705 710 715 720
          Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                          725 730 735
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr
                      740 745 750
          Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  755 760 765
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu
              770 775 780
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro
          785 790 795 800
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
                          805 810 815
          Pro Gly Thr Glu Ser Thr Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu
                      820 825 830
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr
                  835 840 845
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
              850 855 860
          Pro Gly
          865
           <![CDATA[ <210> 8009]]>
           <![CDATA[ <211> 578]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 8009]]>
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
          1 5 10 15
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
                      20 25 30
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  35 40 45
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
              50 55 60
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser
          65 70 75 80
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                          85 90 95
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                      100 105 110
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro
                  115 120 125
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
              130 135 140
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu
          145 150 155 160
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr
                          165 170 175
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
                      180 185 190
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                  195 200 205
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
              210 215 220
          Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
          225 230 235 240
          Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro
                          245 250 255
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
                      260 265 270
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                  275 280 285
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu
              290 295 300
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr
          305 310 315 320
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
                          325 330 335
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                      340 345 350
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro
                  355 360 365
          Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
              370 375 380
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
          385 390 395 400
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro
                          405 410 415
          Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
                      420 425 430
          Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                  435 440 445
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr
              450 455 460
          Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
          465 470 475 480
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu
                          485 490 495
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro
                      500 505 510
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
                  515 520 525
          Pro Gly Thr Glu Ser Thr Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu
              530 535 540
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr
          545 550 555 560
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                          565 570 575
          Pro Gly
           <![CDATA[ <210> 8010]]>
           <![CDATA[ <211> 1152]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 8010]]>
          Ser Ala Gly Ser Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
          1 5 10 15
          Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                      20 25 30
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro
                  35 40 45
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
              50 55 60
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
          65 70 75 80
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Thr Pro Ala Glu Ser
                          85 90 95
          Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
                      100 105 110
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
                  115 120 125
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
              130 135 140
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
          145 150 155 160
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
                          165 170 175
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser
                      180 185 190
          Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  195 200 205
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
              210 215 220
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
          225 230 235 240
          Gly Ser Thr Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser
                          245 250 255
          Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr
                      260 265 270
          Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala
                  275 280 285
          Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr
              290 295 300
          Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser
          305 310 315 320
          Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala
                          325 330 335
          Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser
                      340 345 350
          Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr
                  355 360 365
          Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro
              370 375 380
          Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser
          385 390 395 400
          Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser
                          405 410 415
          Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro
                      420 425 430
          Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser
                  435 440 445
          Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
              450 455 460
          Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr
          465 470 475 480
          Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser
                          485 490 495
          Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr
                      500 505 510
          Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser
                  515 520 525
          Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr
              530 535 540
          Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr
          545 550 555 560
          Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro
                          565 570 575
          Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser
                      580 585 590
          Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                  595 600 605
          Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr
              610 615 620
          Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser
          625 630 635 640
          Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser
                          645 650 655
          Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala
                      660 665 670
          Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu
                  675 680 685
          Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser
              690 695 700
          Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser
          705 710 715 720
          Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser
                          725 730 735
          Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr
                      740 745 750
          Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala
                  755 760 765
          Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu
              770 775 780
          Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser
          785 790 795 800
          Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro
                          805 810 815
          Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser
                      820 825 830
          Ala Pro Gly Ser Glu Pro Ala Thr Ser Ser Gly Ser Glu Thr Pro Gly Thr
                  835 840 845
          Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro
              850 855 860
          Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Ser Thr
          865 870 875 880
          Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr
                          885 890 895
          Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser
                      900 905 910
          Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser
                  915 920 925
          Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr
              930 935 940
          Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr
          945 950 955 960
          Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu
                          965 970 975
          Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr
                      980 985 990
          Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro
                  995 1000 1005
          Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly
              1010 1015 1020
          Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
              1025 1030 1035
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
              1040 1045 1050
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala
              1055 1060 1065
          Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly
              1070 1075 1080
          Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
              1085 1090 1095
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
              1100 1105 1110
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro
              1115 1120 1125
          Ser Glu Gly Ser Ala Pro Gly Thr Ser Ser Glu Ser Ala Thr Pro Glu
              1130 1135 1140
          Ser Gly Pro Gly Thr Glu Ser Ala Ser
              1145 1150
           <![CDATA[ <210> 8011]]>
           <![CDATA[ <211> 1153]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 8011]]>
          Ser Ala Gly Ser Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
          1 5 10 15
          Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                      20 25 30
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro
                  35 40 45
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
              50 55 60
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
          65 70 75 80
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
                          85 90 95
          Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
                      100 105 110
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
                  115 120 125
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
              130 135 140
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
          145 150 155 160
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
                          165 170 175
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser
                      180 185 190
          Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  195 200 205
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
              210 215 220
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
          225 230 235 240
          Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                          245 250 255
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                      260 265 270
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr
                  275 280 285
          Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
              290 295 300
          Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu
          305 310 315 320
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr
                          325 330 335
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                      340 345 350
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                  355 360 365
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser
              370 375 380
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
          385 390 395 400
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro
                          405 410 415
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser
                      420 425 430
          Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  435 440 445
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
              450 455 460
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
          465 470 475 480
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                          485 490 495
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                      500 505 510
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro
                  515 520 525
          Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
              530 535 540
          Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
          545 550 555 560
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
                          565 570 575
          Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                      580 585 590
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
                  595 600 605
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
              610 615 620
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
          625 630 635 640
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro
                          645 650 655
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
                      660 665 670
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
                  675 680 685
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro
              690 695 700
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro
          705 710 715 720
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
                          725 730 735
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                      740 745 750
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr
                  755 760 765
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
              770 775 780
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro
          785 790 795 800
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser
                          805 810 815
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                      820 825 830
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
                  835 840 845
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
              850 855 860
          Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
          865 870 875 880
          Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                          885 890 895
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro
                      900 905 910
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
                  915 920 925
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
              930 935 940
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
          945 950 955 960
          Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Thr Glu
                          965 970 975
          Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr
                      980 985 990
          Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro
                  995 1000 1005
          Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly
              1010 1015 1020
          Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
              1025 1030 1035
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ala
              1040 1045 1050
          Thr Glu Ser Pro Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala
              1055 1060 1065
          Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly
              1070 1075 1080
          Ser Ala Pro Gly Thr Ser Ala Glu Ser Ala Thr Pro Glu Ser Gly
              1085 1090 1095
          Pro Gly Ser Glu Pro Ala Thr Ser Ser Gly Ser Glu Thr Pro Gly Thr
              1100 1105 1110
          Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu
              1115 1120 1125
          Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro
              1130 1135 1140
          Glu Ser Gly Pro Gly Thr Glu Ser Ala Ser
              1145 1150
           <![CDATA[ <210> 8012]]>
           <![CDATA[ <211> 864]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 8012]]>
          Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu
          1 5 10 15
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu
                      20 25 30
          Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
                  35 40 45
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Ser Thr
              50 55 60
          Glu Pro Ser Glu Gly Ser Ala Pro Ala Thr Ser Glu Ser Ala Thr Pro
          65 70 75 80
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro
                          85 90 95
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala
                      100 105 110
          Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Ser Pro
                  115 120 125
          Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
              130 135 140
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala
          145 150 155 160
          Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu
                          165 170 175
          Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
                      180 185 190
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Ser Thr
                  195 200 205
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro
              210 215 220
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro
          225 230 235 240
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Ser Thr
                          245 250 255
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro
                      260 265 270
          Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                  275 280 285
          Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu
              290 295 300
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly
          305 310 315 320
          Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                          325 330 335
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Ser Thr
                      340 345 350
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu
                  355 360 365
          Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
              370 375 380
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Ser Thr
          385 390 395 400
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr
                          405 410 415
          Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala Pro
                      420 425 430
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro
                  435 440 445
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro
              450 455 460
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro
          465 470 475 480
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Ser Thr
                          485 490 495
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro
                      500 505 510
          Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
                  515 520 525
          Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala
              530 535 540
          Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro
          545 550 555 560
          Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
                          565 570 575
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro
                      580 585 590
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro
                  595 600 605
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro
              610 615 620
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Ser Thr
          625 630 635 640
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr
                          645 650 655
          Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                      660 665 670
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu
                  675 680 685
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr
              690 695 700
          Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
          705 710 715 720
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu
                          725 730 735
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Ser Glu Ser Ala Thr Pro
                      740 745 750
          Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                  755 760 765
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro
              770 775 780
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr
          785 790 795 800
          Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala Pro
                          805 810 815
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro
                      820 825 830
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro
                  835 840 845
          Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
              850 855 860
           <![CDATA[ <210> 8013]]>
           <![CDATA[ <211> 864]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 8013]]>
          Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu
          1 5 10 15
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu
                      20 25 30
          Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
                  35 40 45
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Ser Thr
              50 55 60
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro
          65 70 75 80
          Glu Ser Gly Pro Gly Ser Glu Ser Ala Thr Ser Ser Gly Ser Glu Thr Pro
                          85 90 95
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala
                      100 105 110
          Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro
                  115 120 125
          Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
              130 135 140
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala
          145 150 155 160
          Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu
                          165 170 175
          Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
                      180 185 190
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Ser Thr
                  195 200 205
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro
              210 215 220
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro
          225 230 235 240
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Ser Thr
                          245 250 255
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro
                      260 265 270
          Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                  275 280 285
          Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu
              290 295 300
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly
          305 310 315 320
          Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                          325 330 335
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Ser Thr
                      340 345 350
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu
                  355 360 365
          Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
              370 375 380
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Ser Thr
          385 390 395 400
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr
                          405 410 415
          Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala Pro
                      420 425 430
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro
                  435 440 445
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro
              450 455 460
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro
          465 470 475 480
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Ser Thr
                          485 490 495
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro
                      500 505 510
          Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
                  515 520 525
          Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala
              530 535 540
          Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro
          545 550 555 560
          Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
                          565 570 575
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro
                      580 585 590
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro
                  595 600 605
          Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro
              610 615 620
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Ser Thr
          625 630 635 640
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr
                          645 650 655
          Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                      660 665 670
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu
                  675 680 685
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr
              690 695 700
          Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
          705 710 715 720
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu
                          725 730 735
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Ser Glu Ser Ala Thr Pro
                      740 745 750
          Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                  755 760 765
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro
              770 775 780
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr
          785 790 795 800
          Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala Pro
                          805 810 815
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro
                      820 825 830
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro
                  835 840 845
          Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
              850 855 860
           <![CDATA[ <210> 8014]]>
           <![CDATA[ <211> 292]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 8014]]>
          Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Ser Gly Thr Ser Glu Ser
          1 5 10 15
          Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly
                      20 25 30
          Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly
                  35 40 45
          Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser
              50 55 60
          Ala Thr Pro Glu Ser Gly Pro Gly Ser Thr Pro Ala Glu Ser Gly Ser
          65 70 75 80
          Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly
                          85 90 95
          Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly
                      100 105 110
          Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu
                  115 120 125
          Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
              130 135 140
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly
          145 150 155 160
          Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser
                          165 170 175
          Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
                      180 185 190
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser
                  195 200 205
          Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu
              210 215 220
          Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
          225 230 235 240
          Ser Glu Pro Ala Thr Ser Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly
                          245 250 255
          Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Thr Glu Gly
                      260 265 270
          Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
                  275 280 285
          Gly Ser Ala Pro
              290
           <![CDATA[ <210> 8015]]>
           <![CDATA[ <211> 582]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 8015]]>
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
          1 5 10 15
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
                      20 25 30
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  35 40 45
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
              50 55 60
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser
          65 70 75 80
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                          85 90 95
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                      100 105 110
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro
                  115 120 125
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
              130 135 140
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu
          145 150 155 160
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr
                          165 170 175
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
                      180 185 190
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                  195 200 205
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
              210 215 220
          Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
          225 230 235 240
          Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro
                          245 250 255
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
                      260 265 270
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                  275 280 285
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu
              290 295 300
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr
          305 310 315 320
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
                          325 330 335
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                      340 345 350
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro
                  355 360 365
          Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
              370 375 380
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
          385 390 395 400
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro
                          405 410 415
          Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
                      420 425 430
          Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                  435 440 445
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr
              450 455 460
          Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
          465 470 475 480
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu
                          485 490 495
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro
                      500 505 510
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
                  515 520 525
          Pro Gly Thr Glu Ser Thr Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu
              530 535 540
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr
          545 550 555 560
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                          565 570 575
          Pro Gly Glu Pro Glu Ala
                      580
           <![CDATA[ <210> 8016]]>
           <![CDATA[ <211> 576]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 8016]]>
          Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser
          1 5 10 15
          Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr
                      20 25 30
          Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr
                  35 40 45
          Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser
              50 55 60
          Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr
          65 70 75 80
          Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro
                          85 90 95
          Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser
                      100 105 110
          Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr
                  115 120 125
          Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser
              130 135 140
          Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser
          145 150 155 160
          Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser
                          165 170 175
          Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala
                      180 185 190
          Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu
                  195 200 205
          Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr
              210 215 220
          Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala
          225 230 235 240
          Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr
                          245 250 255
          Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser
                      260 265 270
          Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala
                  275 280 285
          Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser
              290 295 300
          Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser
          305 310 315 320
          Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala
                          325 330 335
          Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu
                      340 345 350
          Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr
                  355 360 365
          Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser
              370 375 380
          Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser
          385 390 395 400
          Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr
                          405 410 415
          Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser
                      420 425 430
          Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr
                  435 440 445
          Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr
              450 455 460
          Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala
          465 470 475 480
          Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser
                          485 490 495
          Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser
                      500 505 510
          Glu Ser Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser
                  515 520 525
          Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser
              530 535 540
          Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser
          545 550 555 560
          Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala
                          565 570 575
           <![CDATA[ <210> 8017]]>
           <![CDATA[ <211> 576]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 8017]]>
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu
          1 5 10 15
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly
                      20 25 30
          Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro
                  35 40 45
          Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu
              50 55 60
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu
          65 70 75 80
          Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
                          85 90 95
          Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr
                      100 105 110
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu
                  115 120 125
          Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
              130 135 140
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu
          145 150 155 160
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly
                          165 170 175
          Ser Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
                      180 185 190
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu
                  195 200 205
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Ser Glu Ser Ala Thr Pro
              210 215 220
          Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
          225 230 235 240
          Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro
                          245 250 255
          Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro
                      260 265 270
          Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
                  275 280 285
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Ser Thr
              290 295 300
          Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu
          305 310 315 320
          Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro
                          325 330 335
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala
                      340 345 350
          Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu
                  355 360 365
          Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
              370 375 380
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu
          385 390 395 400
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly
                          405 410 415
          Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                      420 425 430
          Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu
                  435 440 445
          Ser Ala Ser Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr
              450 455 460
          Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu
          465 470 475 480
          Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu
                          485 490 495
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu
                      500 505 510
          Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                  515 520 525
          Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu
              530 535 540
          Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly
          545 550 555 560
          Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro
                          565 570 575
           <![CDATA[ <210> 8018]]>
           <![CDATA[ <211> 576]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 8018]]>
          Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
          1 5 10 15
          Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                      20 25 30
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser
                  35 40 45
          Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
              50 55 60
          Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
          65 70 75 80
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
                          85 90 95
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                      100 105 110
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu
                  115 120 125
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser
              130 135 140
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
          145 150 155 160
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                          165 170 175
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro
                      180 185 190
          Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  195 200 205
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
              210 215 220
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
          225 230 235 240
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                          245 250 255
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                      260 265 270
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser
                  275 280 285
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
              290 295 300
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
          305 310 315 320
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
                          325 330 335
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
                      340 345 350
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu
                  355 360 365
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr
              370 375 380
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
          385 390 395 400
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro
                          405 410 415
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro
                      420 425 430
          Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
                  435 440 445
          Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
              450 455 460
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
          465 470 475 480
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Thr Glu
                          485 490 495
          Thr Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu
                      500 505 510
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr
                  515 520 525
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
              530 535 540
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
          545 550 555 560
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
                          565 570 575
           <![CDATA[ <210> 8019]]>
           <![CDATA[ <211> 576]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 8019]]>
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
          1 5 10 15
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                      20 25 30
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
                  35 40 45
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
              50 55 60
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
          65 70 75 80
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
                          85 90 95
          Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                      100 105 110
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
                  115 120 125
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
              130 135 140
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
          145 150 155 160
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                          165 170 175
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser
                      180 185 190
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                  195 200 205
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
              210 215 220
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro
          225 230 235 240
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
                          245 250 255
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu
                      260 265 270
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr
                  275 280 285
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
              290 295 300
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
          305 310 315 320
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
                          325 330 335
          Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
                      340 345 350
          Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro
                  355 360 365
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
              370 375 380
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
          385 390 395 400
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu
                          405 410 415
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr
                      420 425 430
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
                  435 440 445
          Pro Gly Thr Ser Glu Ser Ala Ser Pro Glu Ser Gly Pro Gly Thr Ser
              450 455 460
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro
          465 470 475 480
          Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                          485 490 495
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
                      500 505 510
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro
                  515 520 525
          Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
              530 535 540
          Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
          545 550 555 560
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr
                          565 570 575
           <![CDATA[ <210> 8020]]>
           <![CDATA[ <211> 294]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 8020]]>
          Ala Ser Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Ser Gly Thr Ser
          1 5 10 15
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
                      20 25 30
          Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  35 40 45
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser
              50 55 60
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Thr Pro Ala Glu Ser
          65 70 75 80
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                          85 90 95
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro
                      100 105 110
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
                  115 120 125
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
              130 135 140
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro
          145 150 155 160
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro
                          165 170 175
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
                      180 185 190
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                  195 200 205
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr
              210 215 220
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
          225 230 235 240
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro
                          245 250 255
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser
                      260 265 270
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                  275 280 285
          Pro Gly Gly Ser Ala Pro
              290
           <![CDATA[ <210> 8021]]>
           <![CDATA[ <211> 292]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 8021]]>
          Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser
          1 5 10 15
          Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly
                      20 25 30
          Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly
                  35 40 45
          Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser
              50 55 60
          Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser
          65 70 75 80
          Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly
                          85 90 95
          Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly
                      100 105 110
          Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu
                  115 120 125
          Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
              130 135 140
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly
          145 150 155 160
          Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser
                          165 170 175
          Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
                      180 185 190
          Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser
                  195 200 205
          Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu
              210 215 220
          Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly
          225 230 235 240
          Ser Glu Pro Ala Thr Ser Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly
                          245 250 255
          Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Thr Glu Gly
                      260 265 270
          Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly
                  275 280 285
          Gly Ser Ala Pro
              290
           <![CDATA[ <210> 8022]]>
           <![CDATA[ <211> 584]]>
           <![CDATA[ <212> PRT]]>
           <![CDATA[ <213> Artificial Sequence]]>
           <![CDATA[ <220>]]>
           <![CDATA[ <223> Synthesized]]>
           <![CDATA[ <400> 8022]]>
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
          1 5 10 15
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser
                      20 25 30
          Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
                  35 40 45
          Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
              50 55 60
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
          65 70 75 80
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
                          85 90 95
          Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro
                      100 105 110
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
                  115 120 125
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
              130 135 140
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro
          145 150 155 160
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser
                          165 170 175
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                      180 185 190
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                  195 200 205
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
              210 215 220
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
          225 230 235 240
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                          245 250 255
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
                      260 265 270
          Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                  275 280 285
          Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser
              290 295 300
          Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser
          305 310 315 320
          Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly
                          325 330 335
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
                      340 345 350
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser
                  355 360 365
          Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
              370 375 380
          Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser
          385 390 395 400
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro
                          405 410 415
          Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Ser Glu Gly Ser Ala
                      420 425 430
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu
                  435 440 445
          Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Ser Glu Ser Ala Thr
              450 455 460
          Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr
          465 470 475 480
          Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser
                          485 490 495
          Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr
                      500 505 510
          Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu
                  515 520 525
          Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro
              530 535 540
          Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr
          545 550 555 560
          Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala
                          565 570 575
          Pro Gly Ala Ala Glu Pro Glu Ala
                      580
          
      

Claims (142)

A polypeptide having an N-terminal amino acid and a C-terminal amino acid, the polypeptide comprising: (a) an expanded recombinant polypeptide ( XTEN ), comprising: a barcode fragment ( BAR ) that can be released from the polypeptide after protease digestion; (b) a bispecific antibody construct ( BsAb ), which comprises: a first antigen-binding fragment ( AF1 ) that specifically binds to the cluster of differentiation 3 T cell receptor (CD3), and the AF1 comprises a light chain complementarity determining region 1 ( CDR-L1), 2 (CDR-L2) and 3 (CDR-L3) and heavy chain complementarity determining regions 1 (CDR-H1), 2 (CDR-H2) and 3 (CDR-H3), wherein the CDR-H3 comprising the amino acid sequence of SEQ ID NO: 10 ; and a second antigen-binding fragment ( AF2 ) specifically binding to human epidermal growth factor receptor 2 (HER2); and (c) located between the XTEN and the bispecific antibody The release segment ( RS ) between constructs, wherein the XTEN is characterized in that: (i) it comprises at least 100 or at least 150 amino acids; (ii) at least 90% of its amino acid residues are herein identified by glycine (G), alanine (A), serine (S), threonine (T), glutamic acid (E) or proline (P); (iii) its comprising at least 4 different types of amino acids identified herein by G, A, S, T, E or P; and (iv) the XTEN consists of a plurality of each of 9 to 14 amino acids in length Non-overlapping sequence motif formation, wherein the plurality of non-overlapping sequence motifs comprises: (1) a set of non-overlapping sequence motifs, wherein each non-overlapping sequence motif in the set of non-overlapping sequence motifs is repeated in the XTEN at least twice; and (2) a non-overlapping sequence motif that occurs only once within the XTEN; wherein the barcode segment ( BAR ) includes at least a portion of the non-overlapping sequence motif that occurs only once within the XTEN; wherein The barcode fragment ( BAR ) differs in sequence and molecular weight from all other peptide fragments that can be released from the polypeptide after complete digestion of the polypeptide by the protease; and wherein the barcode fragment ( BAR ) does not include the N-terminus of the polypeptide amino acid or the C-terminal amino acid. The polypeptide according to claim 1, wherein the set of non-overlapping sequence motifs are each independently identified herein by SEQ ID NO: 179-200 and 1715-1722 . The polypeptide according to claim 1 or 2, wherein the set of non-overlapping sequence motifs are each independently identified herein by SEQ ID NO: 186-189 . The polypeptide according to claim 3, wherein the set of non-overlapping sequence motifs comprises at least two, at least three or all four of the sequence motifs SEQ ID NO: 186-189 . The polypeptide according to any one of claims 1 to 4, wherein the XTEN comprises 100 to 3,000, 150 to 3,000, 100 to 1,000 or 150 to 1,000 amino acid residues in length. The polypeptide according to any one of claims 1 to 5, wherein the XTEN comprises at least 200, at least 250, at least 300, at least 350, at least 400, at least 450 or at least 500 amino acid residues in length. The polypeptide according to any one of claims 1 to 6, wherein at least 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% Glycine (G), Alanine (A), Serine (S), Threonine (T), Glutamine (E) or Proline (P). The polypeptide according to any one of claims 1 to 7, wherein the XTEN has at least 90%, at least 92%, at least 95%, at least 98%, at least 99% or 100% sequence identity with the sequence set forth in Table 3a . The polypeptide according to any one of claims 1 to 8, wherein the barcode segment ( BAR ) does not include a glutamic acid next to another glutamic acid (if present) in the XTEN. The polypeptide according to any one of claims 1 to 9, wherein the barcode fragment ( BAR ) has glutamic acid at its C-terminus. The polypeptide according to any one of claims 1 to 10, wherein the barcode fragment ( BAR ) has an N-terminal amino acid immediately after the glutamic acid residue. The polypeptide according to any one of claims 1 to 11, wherein the barcode fragment ( BAR ) is positioned at a distance from the N-terminus of the polypeptide or the C-terminus of the polypeptide, wherein the distance is 10 to 150 amino acids or 10 to 125 amino acids in length. The polypeptide according to any one of claims 1 to 12, wherein the barcode segment ( BAR ) is characterized in that: (i) it does not include glutamic acid next to another glutamic acid (if present) in the XTEN; ( ii) it has glutamic acid at its C-terminus; (iii) it has an N-terminal amino acid immediately following the glutamic acid residue; The C-termini are positioned at a distance apart, wherein the distance is 10 to 150 amino acids or 10 to 125 amino acids in length. The polypeptide according to any one of claims 11 to 13, wherein the glutamic acid residue before the N-terminal amino acid of the barcode segment ( BAR ) is not adjacent to another glutamic acid residue. The polypeptide according to any one of claims 1 to 14, wherein the barcode segment ( BAR ) does not include a second glutamic acid residue at a position other than the C-terminus of the barcode segment, unless the second glutamic acid This is followed by proline. The polypeptide according to any one of claims 1 to 15, wherein the XTEN is located at the N-terminus of the bispecific antibody construct ( BsAb ), and wherein the barcode fragment ( BAR ) is located at 200, 150 of the N-terminus of the polypeptide within 1, 100 or 50 amino acids. The polypeptide according to any one of claims 1 to 16, wherein the XTEN is located at the N-terminus of the bispecific antibody construct ( BsAb ), and wherein the barcode fragment ( BAR1 ) is located 10 and 10 distances from the N-terminus of the protein Between 200, between 30 and 200, between 40 and 150, or between 50 and 100 amino acid positions. The polypeptide according to any one of claims 1 to 15, wherein the XTEN is located at the C-terminus of the bispecific antibody construct ( BsAb ), and wherein the barcode fragment ( BAR ) is located at 200, 150 of the C-terminus of the polypeptide within 1, 100 or 50 amino acids. The polypeptide according to any one of claims 1 to 15 and 18, wherein the XTEN is located at the C-terminus of the bispecific antibody construct ( BsAb ), and the barcode fragment ( BAR ) is located at 10 distances from the C-terminus of the protein Between 200 and 200, between 30 and 200, between 40 and 150, or between 50 and 100 amino acid positions. The polypeptide according to any one of claims 1 to 19, wherein the barcode segment ( BAR ) is at least 4 amino acids in length. The polypeptide of claim 20, wherein the length of the barcode segment ( BAR ) is between 4 and 20, between 5 and 15, between 6 and 12 or between 7 and 10 between amino acids. The polypeptide according to any one of claims 1 to 21, wherein the barcode fragment ( BAR ) comprises the amino acid sequence set forth in Table 2 . The polypeptide according to any one of claims 1 to 22, wherein the length of the XTEN is defined by a proximal end and a distal end, wherein (1) the proximal end is closer to the bispecific antibody construct than the distal end ( BsAb ) localization, and wherein (2) the barcode segment ( BAR ) is located between 5% and 50%, between 7% and 40%, or 10% of the length of the XTEN as measured from the distal end within the area of the XTEN extending between and 30%. The polypeptide according to any one of claims 1 to 23, wherein the XTEN further comprises additional one or more barcode fragments, wherein each of the additional one or more barcode fragments is releasable from the polypeptide after the protease completely digests the polypeptide All other peptide fragments differ in sequence and molecular weight. The polypeptide according to any one of claims 1 to 24, wherein the release segment ( RS ) comprises at least 90%, 91%, 92%, An amino acid sequence having 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% sequence identity. The polypeptide according to any one of claims 1 to 25, wherein the protease cleaves on the C-terminal side of the glutamic acid residue not followed by proline. The polypeptide according to claim 26, wherein the protease is Glu-C protease. The polypeptide according to any one of claims 1 to 27, which is expressed as a fusion protein, wherein the fusion protein in an uncleaved state has the expression of AF1-AF2-RS-XTEN, AF2 herein from N-terminus to C-terminus - Structural arrangements identified by AF1-RS-XTEN, XTEN-RS-AF1-AF2 or XTEN-RS-AF2-AF1. The polypeptide according to claims 1 to 28, wherein the release segment ( RS ) is fused to the bispecific antibody construct ( BsAb ) via a spacer. The polypeptide according to claim 29, wherein the spacer comprises at least 4 types of amino acids, and these amino acids are glycine (G), alanine (A), serine (S), threonine (T), glutamic acid (E) or proline (P). The polypeptide of claim 29, wherein the spacer comprises an amino acid sequence having at least 80%, 90% or 100% sequence identity with the sequence set forth in Table C. The polypeptide according to any one of claims 1 to 31, wherein the CDR-H1 and the CDR-H2 of the first antigen-binding fragment ( AF1 ) comprise the amino acid sequences of SEQ ID NO: 8 and 9 , respectively. The polypeptide according to any one of claims 1 to 32, wherein: the CDR-L1 of the AF1 comprises the amino acid sequence of SEQ ID NO: 1 or 2 ; the CDR-L2 of the AF1 comprises SEQ ID NO: 4 or the amino acid sequence of 5 ; and the CDR-L3 of the AF1 comprises the amino acid sequence of SEQ ID NO:6 . The polypeptide according to any one of claims 1 to 32, wherein: the CDR-L1 of the AF1 comprises the amino acid sequence of SEQ ID NO:1 ; the CDR-L2 of the AF1 comprises the amino acid sequence of SEQ ID NO:4 or 5 an amino acid sequence; and the CDR-L3 of the AF1 comprises the amino acid sequence of SEQ ID NO:6 . The polypeptide according to any one of claims 1 to 32, wherein: the CDR-L1 of the AF1 comprises the amino acid sequence of SEQ ID NO:2 ; the CDR-L2 of the AF1 comprises the amino acid sequence of SEQ ID NO:4 or 5 an amino acid sequence; and the CDR-L3 of the AF1 comprises the amino acid sequence of SEQ ID NO:6 . The polypeptide according to any one of claims 1 to 32, wherein: the CDR-L1 of the AF1 comprises the amino acid sequence of SEQ ID NO:1 ; the CDR-L2 of the AF1 comprises the amine group of SEQ ID NO:4 and the CDR-L3 of the AF1 comprises the amino acid sequence of SEQ ID NO:6 . The polypeptide according to any one of claims 1 to 32, wherein: the CDR-L1 of the AF1 comprises the amino acid sequence of SEQ ID NO:2 ; the CDR-L2 of the AF1 comprises the amine group of SEQ ID NO:5 and the CDR-L3 of the AF1 comprises the amino acid sequence of SEQ ID NO:6 . The polypeptide according to any one of claims 1 to 37, wherein the first antigen-binding fragment ( AF1 ) comprises four chain variable domain framework regions 1 (FR-H1), 2 (FR-H2), 3 (FR- H3) and 4 (FR- H4 ) , the framework regions respectively exhibit at least 86 % , 87 %, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99% sequence identity or identity to the amino acid sequence. The polypeptide according to any one of claims 1 to 37, wherein the first antigen-binding fragment ( AF1 ) comprises four chain variable domain framework regions 1 (FR-H1), 2 (FR-H2), 3 (FR- H3) and 4 (FR- H4 ), the framework regions respectively exhibit at least 86 % , 87 %, 88% , 89 % , 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99% sequence identity or identity to the amino acid sequence. The polypeptide according to any one of claims 1 to 39, wherein the first antigen-binding fragment further comprises four light chain variable domain framework regions (FR-L): FR-L1, FR-L2, FR-L3 and FR -L4, each of the framework regions exhibits at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93% of the amino acid sequences of SEQ ID NO: 51 , 52 , 53 , and 59 , respectively %, 94%, 95%, 96%, 97%, 98% or 99% sequence identity or is identical to such amino acid sequences. The polypeptide according to any one of claims 1 to 39, wherein the first antigen-binding fragment further comprises four light chain variable domain framework regions (FR-L): FR-L1, FR-L2, FR-L3 and FR -L4, each of the framework regions exhibits at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93% of the amino acid sequences of SEQ ID NO: 51 , 52 , 54 , and 59 , respectively %, 94%, 95%, 96%, 97%, 98% or 99% sequence identity or is identical to such amino acid sequences. The polypeptide according to any one of claims 1 to 39, wherein the first antigen-binding fragment further comprises four light chain variable domain framework regions (FR-L): FR-L1, FR-L2, FR-L3 and FR -L4, each of the framework regions exhibits at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93% of the amino acid sequences of SEQ ID NO: 51 , 52 , 55 and 59 , respectively %, 94%, 95%, 96%, 97%, 98% or 99% sequence identity or is identical to such amino acid sequences. The polypeptide according to any one of claims 1 to 39, wherein the first antigen-binding fragment further comprises four light chain variable domain framework regions (FR-L): FR-L1, FR-L2, FR-L3 and FR -L4, each of the framework regions exhibits at least 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93% of the amino acid sequence of SEQ ID NO: 51 , 52 , 56 and 59 , respectively %, 94%, 95%, 96%, 97%, 98% or 99% sequence identity or is identical to such amino acid sequences. The polypeptide according to any one of claims 1 to 39, wherein the first antigen-binding fragment ( AF1 ) further comprises light chain framework regions 1 (FR-L1), 2 (FR-L2), 3 (FR-L3) and 4 (FR-L4) and heavy chain framework regions 1 (FR-H1), 2 (FR-H2), 3 (FR-H3) and 4 (FR-H4), wherein: the FR-L1 comprises SEQ ID NO: The amino acid sequence of 51 ; the FR-L2 comprises the amino acid sequence of SEQ ID NO:52 ; the FR-L3 comprises the amino acid sequence of SEQ ID NO:53 , 54 , 55 or 56 ; the FR-L4 comprises The amino acid sequence of SEQ ID NO:59 ; the FR-H1 comprises the amino acid sequence of SEQ ID NO:60 or 61 ; the FR-H2 comprises the amino acid sequence of SEQ ID NO:64 ; the FR-H3 comprises The amino acid sequence of SEQ ID NO:65 ; and the FR-H4 comprises the amino acid sequence of SEQ ID NO:67 . The polypeptide according to any one of claims 1 to 39, wherein the first antigen-binding fragment ( AF1 ) further comprises light chain framework regions 1 (FR-L1), 2 (FR-L2), 3 (FR-L3) and 4 (FR-L4) and heavy chain framework regions 1 (FR-H1), 2 (FR-H2), 3 (FR-H3) and 4 (FR-H4), wherein: the FR-L1 comprises SEQ ID NO: The amino acid sequence of 51 ; the FR-L2 comprises the amino acid sequence of SEQ ID NO:52 ; the FR-L3 comprises the amino acid sequence of SEQ ID NO:53 ; the FR-L4 comprises the amino acid sequence of SEQ ID NO:59 Amino acid sequence; the FR-H1 comprises the amino acid sequence of SEQ ID NO:60 ; the FR-H2 comprises the amino acid sequence of SEQ ID NO:64 ; the FR-H3 comprises the amino acid sequence of SEQ ID NO:65 acid sequence; and the FR-H4 comprises the amino acid sequence of SEQ ID NO:67 . The polypeptide according to any one of claims 1 to 39, wherein the first antigen-binding fragment ( AF1 ) further comprises light chain framework regions 1 (FR-L1), 2 (FR-L2), 3 (FR-L3) and 4 (FR-L4) and heavy chain framework regions 1 (FR-H1), 2 (FR-H2), 3 (FR-H3) and 4 (FR-H4), wherein: the FR-L1 comprises SEQ ID NO: The amino acid sequence of 51 ; the FR-L2 comprises the amino acid sequence of SEQ ID NO:52 ; the FR-L3 comprises the amino acid sequence of SEQ ID NO:54 ; the FR-L4 comprises the amino acid sequence of SEQ ID NO:59 Amino acid sequence; the FR-H1 comprises the amino acid sequence of SEQ ID NO:61 ; the FR-H2 comprises the amino acid sequence of SEQ ID NO:64 ; the FR-H3 comprises the amino acid sequence of SEQ ID NO:65 acid sequence; and the FR-H4 comprises the amino acid sequence of SEQ ID NO:67 . The polypeptide according to any one of claims 1 to 39, wherein the first antigen-binding fragment ( AF1 ) further comprises light chain framework regions 1 (FR-L1), 2 (FR-L2), 3 (FR-L3) and 4 (FR-L4) and heavy chain framework regions 1 (FR-H1), 2 (FR-H2), 3 (FR-H3) and 4 (FR-H4), wherein: the FR-L1 comprises SEQ ID NO: The amino acid sequence of 51 ; the FR-L2 comprises the amino acid sequence of SEQ ID NO:52 ; the FR-L3 comprises the amino acid sequence of SEQ ID NO:55 ; the FR-L4 comprises the amino acid sequence of SEQ ID NO:59 Amino acid sequence; the FR-H1 comprises the amino acid sequence of SEQ ID NO:61 ; the FR-H2 comprises the amino acid sequence of SEQ ID NO:64 ; the FR-H3 comprises the amino acid sequence of SEQ ID NO:65 acid sequence; and the FR-H4 comprises the amino acid sequence of SEQ ID NO:67 . The polypeptide according to any one of claims 1 to 39, wherein the first antigen-binding fragment ( AF1 ) further comprises light chain framework regions 1 (FR-L1), 2 (FR-L2), 3 (FR-L3) and 4 (FR-L4) and heavy chain framework regions 1 (FR-H1), 2 (FR-H2), 3 (FR-H3) and 4 (FR-H4), wherein: the FR-L1 comprises SEQ ID NO: The amino acid sequence of 51 ; the FR-L2 comprises the amino acid sequence of SEQ ID NO:52 ; the FR-L3 comprises the amino acid sequence of SEQ ID NO:56 ; the FR-L4 comprises the amino acid sequence of SEQ ID NO:59 Amino acid sequence; the FR-H1 comprises the amino acid sequence of SEQ ID NO:61 ; the FR-H2 comprises the amino acid sequence of SEQ ID NO:64 ; the FR-H3 comprises the amino acid sequence of SEQ ID NO:65 acid sequence; and the FR-H4 comprises the amino acid sequence of SEQ ID NO:67 . The polypeptide according to any one of claims 1 to 48, wherein the first antigen-binding fragment ( AF1 ) exhibits a higher thermal stability than the anti-CD3 binding fragment consisting of the sequence set forth in SEQ ID NO: 206 , as in In an in vitro assay as demonstrated by: the melting temperature (Tm) of the first antigen-binding fragment is higher relative to the melting temperature ( _Tm ) of the anti-CD3-binding fragment; or After incorporation into a test bispecific antigen binding construct, the Tm of the test bispecific antigen binding construct is higher relative to the _Tm of the control bispecific antigen binding construct, wherein the test bispecific antigen binding The construct comprises the first antigen-binding fragment and a reference antigen-binding fragment that binds to an antigen other than CD3; and wherein the control bispecific antigen-binding construct consists of the anti-CD3 binding fragment and the reference antigen-binding fragment, the anti The CD3 binding fragment consists of the sequence of SEQ ID NO:206 . The polypeptide of claim 49, wherein the _Tm of the first antigen-binding fragment is at least 2°C or at least 3°C or at least 4°C higher than the _Tm of the anti-CD3 binding fragment consisting of the sequence of SEQ ID NO: 206 °C or at least 5 °C. The polypeptide according to any one of claims 1 to 50, wherein the first antigen-binding fragment ( AF1 ) comprises a heavy chain variable region (VH _I ), wherein the VH _I comprises an amino group with SEQ ID NO: 102 or 105 An acid sequence has at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence identity or an amino acid sequence identical to the amino acid sequence. The polypeptide according to any one of claims 1 to 51, wherein the first antigen-binding fragment ( AF1 ) comprises a light chain variable region (VL _I ), wherein the VL _I comprises the same sequence as SEQ ID NO: 101 , 103 , 104 , The amino acid sequence of any of 106 or 107 has at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% sequence identity to or with the amine An amino acid sequence consistent with the amino acid sequence. The polypeptide of claim 51 or 52, wherein the VH _I and the VL _I are connected by a linker, and the linker comprises at least 90%, 91%, 92%, 93%, An amino acid sequence having 94%, 95%, 96%, 97%, 98%, 99% or 100% sequence identity. The polypeptide according to any one of claims 1 to 53, wherein the first antigen-binding fragment ( AF1 ) comprises at least 95%, 96%, 97% of the amino acid sequence of any one of SEQ ID NO: 201-205 %, 98%, 99% sequence identity or an amino acid sequence identical to the amino acid sequence. The polypeptide according to any one of claims 1 to 53, wherein the first antigen-binding fragment ( AF1 ) specifically binds to human or cynomolgus monkey (cyno) CD3. The polypeptide according to claim 55, wherein the first antigen-binding fragment ( AF1 ) specifically binds to human CD3. The polypeptide according to any one of claims 1 to 56, wherein the first antigen-binding fragment ( AF1 ) binds to a CD3 complex subunit identified herein by a CD3ε, CD3δ, CD3γ or CD3ζ unit of CD3. The polypeptide according to claim 57, wherein the first antigen-binding fragment ( AF1 ) binds to the CD3ε fragment of CD3. The polypeptide according to any one of claims 1 to 58, wherein the first antigen-binding fragment ( AF1 ) exhibits an isoelectric point (pi) less than or equal to 6.6. The polypeptide according to claim 59, wherein the first antigen-binding fragment ( AF1 ) exhibits an isoelectric point (pI) between 6.0 and 6.6 inclusive. The polypeptide according to any one of claims 1 to 60, wherein the first antigen-binding fragment ( AF1 ) exhibits an isoelectric point (pI) lower than the reference antigen-binding fragment by at least 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, The pi of 0.7, 0.8, 0.9 or 1.0 pH units, the reference antigen-binding fragment consisting of the sequence shown in SEQ ID NO:206 . The polypeptide according to any one of claims 1 to 61, wherein the first antigen-binding fragment ( AF1 ) specifically binds humans with a dissociation constant (K _d ) constant between about 10 nM and about 400 nM or cyno CD3, as determined in an in vitro antigen binding assay comprising human or cyno CD3 antigen. The polypeptide according to any one of claims 1 to 62, wherein the first antigen-binding fragment ( AF1 ) is less than about 10 nM, or less than about 50 nM, or less than about 100 nM, or less than about 150 nM, or less than about A dissociation constant ( _Kd ) of 200 nM, or less than about 250 nM, or less than about 300 nM, or less than about 350 nM, or less than about 400 nM specifically binds human or cyno CD3 as determined in an in vitro antigen binding assay Determination. The polypeptide according to any one of claims 1 to 63, wherein the first antigen-binding fragment ( AF1 ) exhibits a binding affinity for CD3 relative to the antigen-binding fragment consisting of the amino acid sequence of SEQ ID NO:206 Binding affinity for CD3 that is at least 2-fold, 3-fold, 4-fold, 5-fold, 6-fold, 7-fold, 8-fold, 9-fold, or at least 10-fold weaker, as by respective dissociation in an in vitro antigen binding assay Constant (K _d ) determined. The polypeptide according to any one of claims 1 to 64, wherein the first antigen-binding fragment ( AF1 ) is a chimeric or humanized antigen-binding fragment. The polypeptide according to any one of claims 1 to 65, wherein the first antigen-binding fragment ( AF1 ) is Fv, Fab, Fab', Fab'-SH, linear antibody or single-chain variable fragment (scFv). The polypeptide according to any one of claims 1 to 66, wherein the second antigen-binding fragment ( AF2 ) is Fv, Fab, Fab', Fab'-SH, linear antibody, single domain antibody or single chain variable fragment (scFv ). The polypeptide according to any one of claims 1 to 66, wherein the first antigen-binding fragment and the second antigen-binding fragment are configured as (Fab')2 or a single-chain diabody. The polypeptide according to any one of claims 1 to 68, wherein the second antigen-binding fragment ( AF2 ) comprises: a heavy chain variable region (VH _II ), which is included herein by SEQ ID NO: 778-783 an identified amino acid sequence; and a light chain variable region (VL _II ) comprising the amino acid sequence identified herein by SEQ ID NO: 878-883 . The polypeptide as claimed in claim 69, wherein the VH _II and the VL _II are connected by a linker comprising at least 90%, 91%, 92%, 93%, 94% of the sequence set forth in Table A , 95%, 96%, 97%, 98%, 99% or 100% amino acid sequence identity. The polypeptide according to any one of claims 1 to 70, wherein the first antigen-binding fragment and the second antigen-binding fragment are fused together by a peptide linker. The polypeptide according to claim 70, wherein the peptide linker comprises 2 or 3 types of amino acids, and the amino acids are glycine, serine or proline. The polypeptide of claim 70 or 72, wherein the peptide linker comprises at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% of the sequence set forth in Table B Amino acid sequences with %, 99% or 100% sequence identity. The polypeptide according to any one of claims 1 to 73, wherein: the XTEN is a first expanded recombinant polypeptide ( XTEN1 ); the plurality of non-overlapping sequence motifs forming the XTEN1 are the first plurality of non-overlapping sequence motifs ; the BAR is the first barcode fragment ( BAR1 ); and the RS is the first release segment ( RS1 ); and the polypeptide further comprises: (d) a second expanded recombinant polypeptide ( XTEN2 ), comprising: the protease a second barcode fragment ( BAR2 ) releasable from the polypeptide after digestion; and (e) a second release segment ( RS2 ) located between the second XTEN ( XTEN2 ) and the bispecific antibody construct ( BsAb ) wherein the XTEN2 is characterized in that: (i) it comprises at least 100 or at least 150 amino acids; (ii) at least 90% of its amino acid residues are glycine (G), alanine (A ), serine (S), threonine (T), glutamic acid (E) or proline (P); and (iii) which contain at least 4 different types of amino acids, which Acid is G, A, S, T, E or P; wherein the second barcode fragment ( BAR2 ) differs in sequence and molecular weight from all other peptide fragments that can be released from the polypeptide after complete digestion of the polypeptide by the protease ; and wherein the second barcode fragment ( BAR2 ) does not include the N-terminal amino acid or the C-terminal amino acid of the polypeptide. The polypeptide according to claim 74, wherein the XTEN1 is located at the N-terminal of the bispecific antibody construct, and the XTEN2 is located at the C-terminal of the bispecific antibody construct. The polypeptide according to claim 74, wherein the XTEN1 is located at the C-terminal of the bispecific antibody construct, and the XTEN2 is located at the N-terminal of the bispecific antibody construct. The polypeptide according to any one of claims 74 to 76, wherein: (iv) the XTEN2 is formed by a second plurality of non-overlapping sequence motifs, the length of each of the second plurality of non-overlapping sequence motifs being 9 to 14 Amino acids, wherein the second plurality of non-overlapping sequence motifs comprises: (1) a second set of non-overlapping sequence motifs, wherein each non-overlapping sequence motif in the second set of non-overlapping sequence motifs is within the second set of non-overlapping sequence motifs Two XTENs are repeated at least twice; and (2) a non-overlapping sequence motif that occurs only once in the second XTEN; and wherein the second barcode segment ( BAR2 ) is included in the second XTEN and occurs only once at least a portion of the non-overlapping sequence motif. The polypeptide according to claim 77, wherein the second set of non-overlapping sequence motifs are each independently identified herein by SEQ ID NO: 179-200 and 1715-1722 . The polypeptide according to claim 78, wherein the second set of non-overlapping sequence motifs are each independently identified herein by SEQ ID NO: 186-189 . The polypeptide according to claim 79, wherein the second set of non-overlapping sequence motifs comprises at least two, at least three or all four of the sequence motifs SEQ ID NO: 186-189 . The polypeptide according to any one of claims 74 to 80, wherein the XTEN2 comprises 100 to 3,000, 150 to 3,000, 100 to 1,000 or 150 to 1,000 amino acid residues in length. The polypeptide according to any one of claims 74 to 81, wherein the XTEN2 comprises at least 200, at least 250, at least 300, at least 350, at least 400, at least 450 or at least 500 amino acid residues length. The polypeptide according to any one of claims 74 to 82, wherein at least 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, of the amino acid residues of the XTEN2 99% or 100% Glycine (G), Alanine (A), Serine (S), Threonine (T), Glutamine (E) or Proline (P). The polypeptide according to any one of claims 74 to 83, wherein the XTEN2 has at least 90%, at least 92%, at least 95%, at least 98%, at least 99% or 100% sequence identity with the sequence set forth in Table 3a . The polypeptide according to any one of claims 74 to 84, wherein the second barcode segment ( BAR2 ) does not include a glutamic acid immediately adjacent to another glutamic acid (if present) in the XTEN2. The polypeptide according to any one of claims 74 to 85, wherein the second barcode fragment ( BAR2 ) has glutamic acid at its C-terminus. The polypeptide according to any one of claims 74 to 86, wherein the second barcode segment ( BAR2 ) has an N-terminal amino acid immediately after the glutamic acid residue. The polypeptide according to any one of claims 74 to 87, wherein the second barcode fragment ( BAR2 ) is positioned at a distance from the N-terminus of the polypeptide or the C-terminus of the polypeptide, wherein the distance is 10 to 150 amines amino acids or 10 to 125 amino acids in length. The polypeptide according to any one of claims 74 to 88, wherein the second barcode fragment ( BAR2 ) is characterized in that: (i) it does not include glutamic acid next to another glutamic acid (if present) in the XTEN2 (ii) it has glutamic acid at its C-terminus; (iii) it has an N-terminal amino acid immediately following the glutamic acid residue; The C-termini are positioned at a distance apart, wherein the distance is 10 to 150 amino acids or 10 to 125 amino acids in length. The polypeptide according to any one of claims 87 to 89, wherein the glutamic acid residue preceding the N-terminal amino acid of the BAR2 is not immediately adjacent to another glutamic acid residue. The polypeptide according to any one of claims 74 to 90, wherein the second barcode fragment ( BAR2 ) does not comprise a second glutamic acid residue at a position other than the C-terminus of the second barcode fragment ( BAR2 ), Unless this second glutamic acid is immediately followed by a proline. The polypeptide according to any one of claims 74 to 91, wherein the XTEN2 is located at the N-terminal of the bispecific antibody construct ( BsAb ), and wherein the second barcode fragment ( BAR2 ) is located at the N-terminal 200 of the polypeptide , within 150, 100 or 50 amino acids. The polypeptide according to any one of claims 74 to 92, wherein the XTEN2 is located at the N-terminus of the bispecific antibody construct ( BsAb ), and wherein the second barcode fragment ( BAR2 ) is located at a distance of 10 from the N-terminus of the protein Between 1 and 200, between 30 and 200, between 40 and 150, or between 50 and 100 amino acid positions. The polypeptide according to any one of claims 74 to 93, wherein the XTEN2 is located at the C-terminal of the bispecific antibody construct ( BsAb ), and wherein the second barcode fragment ( BAR2 ) is located at the C-terminal 200 of the polypeptide , within 150, 100 or 50 amino acids. The polypeptide according to any one of claims 74 to 94, wherein the XTEN2 is located at the C-terminus of the bispecific antibody construct ( BsAb ), and the second barcode fragment ( BAR2 ) is located at 10 distances from the C-terminus of the protein Between 200 and 200, between 30 and 200, between 40 and 150, or between 50 and 100 amino acid positions. The polypeptide according to any one of claims 74 to 95, wherein the length of the second barcode segment ( BAR2 ) is at least 4 amino acids. The polypeptide of claim 96, wherein the length of the second barcode segment ( BAR2 ) is between 4 and 20, between 5 and 15, between 6 and 12 or between 7 and 12 Between 10 amino acids. The polypeptide according to any one of claims 74 to 97, wherein the second barcode fragment ( BAR2 ) comprises the amino acid sequence set forth in Table 2 . The polypeptide according to any one of claims 74 to 98, wherein the length of the XTEN2 is defined by a proximal end and a distal end, wherein (1) the proximal end of the XTEN2 is closer to the bispecific than the distal end Antibody construct ( BsAb ) localized and wherein (2) the second barcode fragment ( BAR2 ) is located between 5% and 50%, 7% of the length of the XTEN2 as measured from the distal end of the XTEN2 Within the area of the XTEN2 extending between 40% and 10% and 30%. The polypeptide according to any one of claims 74 to 99, wherein the XTEN2 further comprises additional one or more barcode fragments, wherein each of the additional one or more barcode fragments of the XTEN2 is self-sustainable after the protease completely digests the polypeptide All other peptide fragments released from this polypeptide differ in sequence and molecular weight. The polypeptide according to any one of claims 74 to 100, wherein the first release segment ( RS1 ) is identical in sequence to the second release segment ( RS2 ). The polypeptide according to any one of claims 74 to 100, wherein the sequence of the first release segment ( RS1 ) is different from that of the second release segment ( RS2 ). The polypeptide according to any one of claims 74 to 102, wherein the second release segment ( RS2 ) comprises at least 90%, 91%, 92% of the sequence identified by SEQ ID NO: 7001-7626 herein Amino acid sequences with %, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% sequence identity. The polypeptide according to any one of claims 74 to 103, wherein the first release segment ( RS1 ) and the second release segment ( RS2 ) are each used for one, two or Substrate cleaved by various proteases at three cleavage sites. The polypeptide according to any one of claims 74 to 104, which is expressed as a fusion protein, wherein the fusion protein in an uncleaved state has from the N-terminus to the C-terminus the expression defined herein by XTEN1-RS1-AF1-AF2-RS2 -XTEN2, XTEN1-RS1-AF2-AF1-RS2-XTEN2, XTEN2-RS2-AF1-AF2-RS1-XTEN1, XTEN2-RS2-AF2-AF1-RS1-XTEN1, XTEN1-RS1-Bifunctional Antibody-RS2-XTEN2 or XTEN2-RS2-diabodies-RS1-XTEN1 marked structural arrangement, wherein the diabodies comprise the light chain variable region (VL _I ) of the AF1, the heavy chain variable region (VH _I ) of the AF1, The AF2 light chain variable region (VL _II ) and the AF2 heavy chain variable region (VH _II ). The polypeptide of claims 74 to 105, wherein the spacer of the first release segment ( RS1 ) is a first spacer, and wherein the second release segment ( RS2 ) is connected to the double spacer by a second spacer Specific antibody construct ( BsAb ) fusion. The polypeptide according to claim 106, wherein the second spacer comprises at least 4 types of amino acids, these amino acids are glycine (G), alanine (A), serine (S), threonine amino acid (T), glutamic acid (E) or proline (P). The polypeptide of claim 106, wherein the second spacer comprises at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% of the sequence set forth in Table C , an amino acid sequence with 99% or 100% sequence identity. The polypeptide of claim 74, wherein: (a) the XTEN1 comprises at least about 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, Amino acid sequences of 98%, 99% or 100% sequence identity; (b) the BsAb comprises: (I) the AF1 , which comprises light chain complementarity determining regions 1 (CDR-L1), 2 (CDR-L2) and 3 (CDR-L3) and heavy chain complementarity determining regions 1 (CDR-H1), 2 (CDR-H2) and 3 (CDR-H3), wherein the CDR-H1, the CDR-H2 and the CDR-H3 are respectively comprising the amino acid sequence of SEQ ID NO: 8 , 9 and 10 ; and (II) the AF2 comprising the light chain variable region (VL _II ) identified herein by SEQ ID NO: 778-783 and The heavy chain variable region (VH[g4]II[/g4]) identified herein by SEQ ID NOs: 878-883 ; (c) the RS1 is comprised and identified herein by SEQ ID NOs: 7001- 7626 An amino acid sequence having at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to the identified sequence; (d ) The XTEN2 comprises at least about 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to the sequence set forth in Table 3a and (e) the RS2 comprises at least 90%, 91%, 92%, 93%, 94%, 95%, Amino acid sequences with 96%, 97%, 98%, 99% or 100% sequence identity, wherein the polypeptide has a structural arrangement from N-terminus to C-terminus identified herein by: XTEN1-RS1-AF2 - AF1-RS2-XTEN2, XTEN1-RS1-AF1-AF2-RS2-XTEN2, XTEN2-RS2-AF2-AF1-RS1-XTEN1 or XTEN2-RS2-AF1-AF2-RS1-XTEN1. The polypeptide according to any one of claims 1 to 109, wherein the terminal half-life of the polypeptide is at least two times longer than the terminal half-life of the bispecific antibody construct not linked to any XTEN. The polypeptide according to any one of claims 1 to 110, wherein the immune response of the polypeptide is determined by measuring the production of IgG antibodies that selectively bind to the bispecific antibody construct after administering a comparable dose to the individual The genicity was lower compared to the immunogenicity of the bispecific antibody construct not linked to any XTEN. The polypeptide according to any one of claims 1 to 111, wherein the polypeptide exhibits an apparent molecular weight factor greater than about 3, greater than about 4, greater than about 5, or greater than about 6 under physiological conditions. The polypeptide of claim 1, wherein the polypeptide comprises at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% of the sequence set forth in Table D Or an amino acid sequence with 100% sequence identity. A pharmaceutical composition comprising the polypeptide according to any one of claims 1 to 113 and one or more pharmaceutically suitable excipients. The pharmaceutical composition according to claim 114, wherein the pharmaceutical composition is formulated for intradermal, subcutaneous, oral, intravenous, intraarterial, intraperitoneal, intraperitoneal, intrathecal or intramuscular administration. The pharmaceutical composition according to claim 114 or 115, wherein the pharmaceutical composition is in liquid form or frozen. The pharmaceutical composition according to any one of claims 114 to 116, wherein the pharmaceutical composition is in a prefilled syringe for single injection. The pharmaceutical composition according to claim 117, wherein the pharmaceutical composition is formulated as a freeze-dried powder to be reconstituted before administration. The pharmaceutical composition of claim 114, wherein the composition, at least one additional therapeutic agent constitutes a pharmaceutical combination, and the at least one additional therapeutic agent is selected from the group consisting of antibodies, antibody fragments, antibody conjugates, cytotoxic agents, toxins , radionuclides, immunomodulators, photosensitizing therapeutic agents, radiosensitizers, hormones, anti-angiogenic agents, and combinations thereof. The pharmaceutical composition according to claim 119, wherein the additional therapeutic agent is a PD-1/PD-L1(2) inhibitor. The pharmaceutical combination according to claim 120, wherein the PD-1/PD-L1(2) inhibitor is an anti-PD-1 antibody or an anti-PD-L1 antibody or an anti-PD-L2 antibody. The pharmaceutical combination according to claim 121, wherein the PD-1/PD-L1(2) inhibitor is an anti-PD-1 antibody selected from the group comprising: Nivolumab (Opdivo) , BMS-936558, MDX1106), pembrolizumab (Keytruda, MK-3475, lambrolizumab), pidilizumab (CT-011) , PDR-001, JS001, STI-A1110, AMP-224 and AMP-514 (MEDI0680). The pharmaceutical combination according to claim 121, wherein the PD-1/PD-L1(2) inhibitor is an anti-PD-L1 antibody selected from the group comprising: atezolizumab (Tecentriq ), MPDL3280A), durvalumab (MEDI4736), avelumab (MSB0010718C), BMS-936559 (MDX1105) and LY3300054. The pharmaceutical combination according to claim 121, wherein the PD-1/PD-L1(2) inhibitor is an anti-PD-L2 antibody. The pharmaceutical combination according to claim 119, wherein the combination is a combination package containing components independent of each other. The pharmaceutical combination according to claim 119, wherein the components are administered simultaneously or sequentially in independent dosage forms for the treatment of the same disease. A pharmaceutical combination as claimed in claim 119, which is used as a medicament for treating hyperproliferative disorders. The pharmaceutical combination according to claim 127, wherein the hyperproliferative disorders are selected from the group consisting of breast cancer, respiratory tract cancer, brain cancer, reproductive organ cancer, digestive tract cancer, urinary tract cancer, eye cancer, liver cancer, skin cancer, head and neck cancer carcinoma, thyroid carcinoma, parathyroid carcinoma and their distant metastasis. A use of the polypeptide according to any one of claims 1 to 112 or the pharmaceutical combination according to any one of claims 119 to 128 for preparing a medicament for treating a disease in an individual. As the use of claim 129, wherein the disease is cancer. A method of treating a disease in an individual comprising administering one or more therapeutically effective doses of the pharmaceutical composition according to any one of claims 114 to 118 or any one of claims 119 to 128 to the individual in need The pharmaceutical combination of item. The method of claim 131, wherein the disease is cancer. The method of claim 132, wherein the cancer is selected from the group consisting of glioblastoma, melanoma, cholangiocarcinoma, small cell lung cancer, colorectal cancer, prostate cancer, vaginal cancer, angiosarcoma, non-small cell lung cancer , appendix carcinoma, squamous cell carcinoma, salivary duct carcinoma, adenoid cystic carcinoma, small bowel carcinoma and gallbladder carcinoma. The method of any one of claims 131 to 133, wherein the pharmaceutical composition is administered to the individual in one or more therapeutically effective doses. The method of any one of claims 131 to 134, wherein the pharmaceutical composition is administered to the individual in one or more therapeutically effective doses during the effective administration period. The method according to any one of claims 131 to 134, wherein the individual is a mouse, a rat, a monkey or a human. A nucleic acid comprising (a) a polynucleotide sequence encoding the polypeptide according to any one of claims 1 to 112; or (b) the reverse complement of the (a) polynucleotide sequence. An expression vector comprising the polynucleotide sequence of claims 1 to 112 and a recombination regulatory sequence operably linked to the polynucleotide sequence. A host cell comprising the expression vector according to claim 138. The host cell according to claim 139, wherein the host cell is a prokaryotic cell. The host cell as claimed in claim 140, wherein the host cell is Escherichia coli (E. coli) . The host cell according to claim 139, wherein the host cell is a mammalian cell.

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