TW202228700A - 治療及預防異體抗體所驅動之慢性移植體對抗宿主疾病之方法 - Google Patents

治療及預防異體抗體所驅動之慢性移植體對抗宿主疾病之方法 Download PDF

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TW202228700A
TW202228700A TW110135203A TW110135203A TW202228700A TW 202228700 A TW202228700 A TW 202228700A TW 110135203 A TW110135203 A TW 110135203A TW 110135203 A TW110135203 A TW 110135203A TW 202228700 A TW202228700 A TW 202228700A
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Taiwan
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cgvhd
substituted
unsubstituted
patient
inhibitor
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TW110135203A
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English (en)
Chinese (zh)
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布魯斯 R 布雷札
萊恩 富林
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美商製藥公司
美國明尼蘇達大學評議委員會
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Publication of TW202228700A publication Critical patent/TW202228700A/zh

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
TW110135203A 2013-12-02 2014-12-02 治療及預防異體抗體所驅動之慢性移植體對抗宿主疾病之方法 TW202228700A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361910944P 2013-12-02 2013-12-02
US61/910,944 2013-12-02
US201461973178P 2014-03-31 2014-03-31
US61/973,178 2014-03-31

Publications (1)

Publication Number Publication Date
TW202228700A true TW202228700A (zh) 2022-08-01

Family

ID=53270044

Family Applications (3)

Application Number Title Priority Date Filing Date
TW110135203A TW202228700A (zh) 2013-12-02 2014-12-02 治療及預防異體抗體所驅動之慢性移植體對抗宿主疾病之方法
TW103141826A TWI743019B (zh) 2013-12-02 2014-12-02 治療及預防異體抗體所驅動之慢性移植體對抗宿主疾病之方法
TW112113060A TW202402295A (zh) 2013-12-02 2014-12-02 治療及預防異體抗體所驅動之慢性移植體對抗宿主疾病之方法

Family Applications After (2)

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TW103141826A TWI743019B (zh) 2013-12-02 2014-12-02 治療及預防異體抗體所驅動之慢性移植體對抗宿主疾病之方法
TW112113060A TW202402295A (zh) 2013-12-02 2014-12-02 治療及預防異體抗體所驅動之慢性移植體對抗宿主疾病之方法

Country Status (14)

Country Link
US (6) US20150157634A1 (https=)
EP (1) EP3076975A4 (https=)
JP (5) JP2017501140A (https=)
KR (2) KR20230104754A9 (https=)
CN (2) CN105939717B (https=)
AU (4) AU2014360758B2 (https=)
BR (1) BR112016012158A2 (https=)
CA (2) CA3210338A1 (https=)
EA (1) EA201691020A1 (https=)
IL (4) IL315228A (https=)
MX (2) MX389020B (https=)
PH (2) PH12020552048A1 (https=)
TW (3) TW202228700A (https=)
WO (1) WO2015084857A1 (https=)

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KR20210033067A (ko) 2012-06-04 2021-03-25 파마싸이클릭스 엘엘씨 브루톤 타이로신 키나아제 저해제의 결정 형태
JP2016538270A (ja) 2013-10-25 2016-12-08 ファーマサイクリックス エルエルシー 移植片対宿主病を処置し予防する方法
AR102871A1 (es) 2014-12-03 2017-03-29 Pharmacyclics Llc Métodos de tratamiento de fibrosis
EP3868374A3 (en) * 2016-03-22 2021-11-10 Mayo Foundation for Medical Education and Research Using fatty acid synthase inhibitors to treat fibrosis
WO2018002958A1 (en) * 2016-06-30 2018-01-04 Sun Pharma Advanced Research Company Limited Novel hydrazide containing compounds as btk inhibitors
WO2018075888A1 (en) * 2016-10-21 2018-04-26 Regents Of The University Of Minnesota Materials and methods for treating or preventing graft-versus-host-disease
CZ2017787A3 (cs) 2017-12-08 2019-06-19 Zentiva, K.S. Farmaceutické kompozice obsahující ibrutinib
WO2021038540A1 (en) 2019-08-31 2021-03-04 Sun Pharma Advanced Research Company Limited Cycloalkylidene carboxylic acids and derivatives as btk inhibitors
US12496303B2 (en) 2020-10-19 2025-12-16 Washington University Conditioning agents for use in allogeneic hematopoietic stem cell transplantation
WO2022119931A1 (en) * 2020-12-01 2022-06-09 City Of Hope Prevention and treatment of graft-versus-host disease (gvhd)
WO2022161484A1 (en) * 2021-01-30 2022-08-04 Beigene, Ltd. Methods of treating chronic active antibody-mediated rejection using btk inhibitors
US20240287781A1 (en) 2023-02-28 2024-08-29 Toto Ltd. Wall-mounted flush toilet

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US6326469B1 (en) 1994-04-22 2001-12-04 Sugen, Inc. Megakaryocytic protein tyrosine kinases
US20060182723A1 (en) * 2005-01-25 2006-08-17 Spellberg Brad J Methods for treating refractory infections in neutropenic individuals
KR20080098490A (ko) * 2006-01-13 2008-11-10 파마시클릭스, 인코포레이티드 티로신 키나제 억제제 및 이의 용도
DK2526933T3 (en) 2006-09-22 2015-05-18 Pharmacyclics Inc Inhibitors of Bruton's tyrosine kinase
CA2730930C (en) * 2008-07-16 2015-01-13 Pharmacyclics, Inc. Inhibitors of bruton's tyrosine kinase for the treatment of solid tumors
US8765754B2 (en) * 2009-04-29 2014-07-01 Locus Pharmaceuticals, Inc. Pyrrolotriazine compounds
CA2772204A1 (en) * 2009-08-31 2011-03-03 Amplimmune, Inc. Methods and compositions for the inhibition of transplant rejection
CA3007787C (en) * 2010-06-03 2020-03-10 Pharmacyclics Llc The use of inhibitors of bruton's tyrosine kinase (btk)
US20120071497A1 (en) * 2010-06-03 2012-03-22 Pharmacyclics, Inc. Methods of treating abc-dlbcl using inhibitors of bruton's tyrosine kinase
ES2548414T3 (es) * 2011-07-08 2015-10-16 Novartis Ag Novedosos derivados de pirrolo pirimidina
WO2013155347A1 (en) * 2012-04-11 2013-10-17 Izumi Raquel Bruton's tyrosine kinase inhibitors for hematopoietic mobilization
AU2013266069B2 (en) * 2012-05-25 2018-03-15 Sloan Kettering Institute For Cancer Research Methods for treating GI syndrome and graft versus host disease
CA2898472C (en) * 2013-02-15 2023-03-07 Immunomedics, Inc. Chimeric and humanized anti-histone antibodies
JP2016538270A (ja) * 2013-10-25 2016-12-08 ファーマサイクリックス エルエルシー 移植片対宿主病を処置し予防する方法
IL315294A (en) * 2015-03-03 2024-10-01 Pharmacyclics Llc Pharmaceutical formulations of bruton's tyrosine kinase inhibitor

Also Published As

Publication number Publication date
IL292522A (en) 2022-06-01
US20240293409A1 (en) 2024-09-05
US20180078558A1 (en) 2018-03-22
CN110478353B (zh) 2022-12-30
IL245715A0 (en) 2016-07-31
TWI743019B (zh) 2021-10-21
TW202402295A (zh) 2024-01-16
JP2025118595A (ja) 2025-08-13
CN105939717A (zh) 2016-09-14
JP2024072291A (ja) 2024-05-27
TW201605454A (zh) 2016-02-16
IL315228A (en) 2024-10-01
CA3210338A1 (en) 2015-06-11
AU2020204276A1 (en) 2020-07-16
KR20230104754A9 (ko) 2024-11-15
MX389020B (es) 2025-03-20
AU2024278490A1 (en) 2025-01-09
EP3076975A1 (en) 2016-10-12
US20250381188A1 (en) 2025-12-18
CA2932255C (en) 2023-10-10
PH12020552048A1 (en) 2022-05-11
MX2016006955A (es) 2016-09-07
WO2015084857A1 (en) 2015-06-11
MX2022000209A (es) 2022-02-03
AU2022203810B2 (en) 2024-10-03
AU2014360758B2 (en) 2020-03-26
US20210177854A1 (en) 2021-06-17
CN105939717B (zh) 2019-09-13
KR20160085817A (ko) 2016-07-18
AU2022203810A1 (en) 2022-06-23
US20230100137A1 (en) 2023-03-30
US20150157634A1 (en) 2015-06-11
EP3076975A4 (en) 2017-05-03
PH12016501051A1 (en) 2016-08-15
JP2023029899A (ja) 2023-03-07
JP2020105181A (ja) 2020-07-09
CA2932255A1 (en) 2015-06-11
AU2014360758A1 (en) 2016-06-16
IL276683A (en) 2020-09-30
KR20230104754A (ko) 2023-07-10
BR112016012158A2 (pt) 2017-09-26
JP2017501140A (ja) 2017-01-12
EA201691020A1 (ru) 2017-01-30
CN110478353A (zh) 2019-11-22

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