TW202225130A - Method and device for manufacturing compounds from isobutyric acid and acetic anhydride - Google Patents

Abstract

A device and a method for manufacturing compounds from isobutyric acid and acetic anhydride are provided. The method for manufacturing compounds from isobutyric acid and acetic anhydride includes the following steps. Isobutyric acid is reacted with acetic anhydride to obtain a first mixture, wherein the first mixture includes isobutyric anhydride and acetic acid. The first mixture is subjected to a first purification process to obtain isobutyric anhydride and acetic acid. The isobutyric anhydride is subjected to a pyrolysis process to obtain a second mixture, wherein the second mixture includes dimethyl ketene, isobutyric acid and isobutyric anhydride. A gas-liquid separation process is performed on the second mixture to obtain dimethyl ketene gas and a liquid, wherein the liquid includes isobutyric acid and isobutyric anhydride. The liquid is collected, and then the isobutyric acid in the liquid is reacted with acetic anhydride.

Description

Method for preparing compounds using isobutyric acid and acetic anhydride and apparatus for preparing compounds using isobutyric acid and acetic anhydride

The present disclosure relates to a method and apparatus for preparing compounds using isobutyric acid and acetic anhydride.

2,2,4,4-Tetramethyl-1,3-cyclobutanediol (2,2,4,4-teramethyl-1,3-cyclobutanediol, CBDO) is a multifunctional intermediate with symmetrical structure, It is widely used in the synthesis of copolyesters, such as high-performance polyesters that can replace polycarbonate (PC). The glass transition temperature of traditional polyester is low, and its application in medium and high temperature fields is limited. Adding 2,2,4,4-tetramethyl-1,3-cyclobutanediol can significantly improve the glass transition temperature, weather resistance and transparency of polyester. Polyester synthesized using 2,2,4,4-tetramethyl-1,3-cyclobutanediol has excellent physical properties similar to bisphenol A, such as high impact strength, excellent dimensional stability, glass transition High temperature.

Continuous improvement and control of chemical reaction processes (eg, environmentally friendly processes, reduced energy consumption and waste emissions, increased yield and purity) is an ongoing goal in the chemical industry. Based on the above, the industry needs a novel process for the preparation of 2,2,4,4-tetramethyl-1,3-cyclobutanediol, so as to improve the yield of the obtained product and reduce the generation of by-products.

According to an embodiment of the present disclosure, the present disclosure provides a method for preparing a compound using isobutyric acid and acetic anhydride. The method for preparing compounds using isobutyric acid and acetic anhydride includes the following steps. The isobutyric acid and acetic anhydride are reacted to obtain a first mixture, wherein the first mixture comprises isobutyric anhydride and acetic acid. A first purification process is performed on the first mixture to obtain isobutyric anhydride and acetic acid; a cracking process is performed on the isobutyric anhydride to obtain a second mixture, wherein the second mixture comprises dimethylketene, isobutyric acid and isobutyl acid anhydride; perform a gas-liquid separation process on the second mixture to obtain dimethyl ketene gas and a liquid, wherein the liquid contains isobutyric acid and isobutyric anhydride; and collect the liquid, and make the isobutyric acid in the liquid Reacts with acetic anhydride. According to an embodiment of the present disclosure, the method for preparing a compound using isobutyric acid and acetic anhydride may further include at least one of the following steps. After the first purification process, the acetic acid is collected. A jet suction process is used to collect the dimethylketene gas at 5°C to 25°C and atmospheric pressure (eg, about 750 Torr to 770 Torr). Dimerization of dimethylketene yields 2,2,4,4-tetramethyl-1,3-cyclobutanedione. The 2,2,4,4-tetramethyl-1,3-cyclobutanedione is mixed with a solvent to obtain a solution, wherein the solid content of the solution is 5 wt % to 20 wt %. The solution is hydrogenated with hydrogen to obtain a third mixture, wherein the third mixture comprises 2,2,4,4-tetramethyl-1,3-cyclobutanediol, hydrogen, and a solvent. A second purification process is performed on the third mixture to obtain 2,2,4,4-tetramethyl-1,3-cyclobutanediol.

According to an embodiment of the present disclosure, the present disclosure provides an apparatus for preparing compounds from isobutyric acid and acetic anhydride. The device for preparing compounds from isobutyric acid and acetic anhydride comprises a feeding unit; a first reaction unit, wherein the feeding unit is connected with the first reaction unit, so as to introduce isobutyric acid and acetic anhydride from the feeding unit into the first reaction unit a first reaction unit, wherein the isobutyric acid reacts with acetic anhydride in the first reaction unit to obtain a first mixture, wherein the first mixture comprises isobutyric anhydride and acetic acid; a first purification unit, wherein the first reaction unit Connected with the first purification unit to introduce the first mixture into the first purification unit, wherein the first mixture is subjected to a first purification process in the first purification unit to obtain isobutyric anhydride and acetic acid; a cracking unit , wherein the first purification unit is connected to the cleavage unit to introduce isobutyric anhydride into the cleavage unit, wherein the isobutyric anhydride undergoes a cleavage process in the cleavage unit to obtain a second mixture, wherein the second mixture comprises dimethyl Enone, isobutyric acid and isobutyric anhydride; and, a gas-liquid separation unit, wherein the cracking unit is connected with the gas-liquid separation unit to introduce the second mixture into the gas-liquid separation unit, wherein the second mixture is in the gas-liquid separation unit The separation unit is separated into a dimethylketene gas and a liquid, wherein the liquid contains isobutyric acid and isobutyric anhydride, wherein the feed unit is connected with the gas-liquid separation unit to introduce the liquid into the feed unit. According to an embodiment of the present disclosure, the method for preparing a compound using isobutyric acid and acetic anhydride may further comprise at least one of the following units. An acetic acid collection unit, wherein the acetic acid collection unit is connected with the first purification unit for collecting the acetic acid obtained by the first purification unit. A second reaction unit, wherein the gas-liquid separation unit is connected to the second reaction unit to introduce the dimethyl ketene gas into the second reaction unit, wherein the dimethyl ketene gas is in the second reaction unit During the reaction, 2,2,4,4-tetramethyl-1,3-cyclobutanedione is formed. a suction unit, wherein the second reaction unit is connected with the gas-liquid separation unit through the suction unit, wherein the suction unit performs a jet suction process on the dimethylketene gas to make the second reaction The unit receives the dimethylketene gas at 5°C to 25°C and atmospheric pressure (eg, 750 Torr to 770 Torr). A solvent supply unit, wherein the solvent supply unit is connected with the suction unit to supply a solvent to the suction unit to perform the jet suction process. A solid-liquid separation unit, wherein the second reaction unit is connected with the solid-liquid separation unit to separate the solvent and 2,2,4,4-tetramethyl-1,3-cyclobutane in the second reaction unit The ketone is introduced into the solid-liquid separation unit, and 2,2,4,4-tetramethyl-1,3-cyclobutanedione is separated from the solvent as a solid. A hydrogenation unit, wherein the solid-liquid separation unit is connected to the hydrogenation unit to introduce 2,2,4,4-tetramethyl-1,3-cyclobutanedione into a hydrogenation unit, wherein the solvent supply unit is connected to the hydrogenation unit units are connected to introduce a solvent into the hydrogenation unit, wherein the 2,2,4,4-tetramethyl-1,3-cyclobutanedione is reacted with a hydrogen gas in the presence of a solvent to give a third mixture wherein the The third mixture contains 2,2,4,4-tetramethyl-1,3-cyclobutanediol, hydrogen, and solvent. A second purification unit, wherein the hydrogenation unit is connected to the second purification unit to introduce the third mixture into the second purification unit, wherein the third mixture is subjected to a purification process in the second purification unit to obtain 2,2,4, 4-Tetramethyl-1,3-cyclobutanediol, hydrogen, and solvent. A collection unit, wherein the collection unit is connected with the second purification unit for collecting 2,2,4,4-tetramethyl-1,3-cyclobutanediol.

According to an embodiment of the present disclosure, the present disclosure provides a method for preparing a compound using isobutyric acid and acetic anhydride. The method for preparing compounds using isobutyric acid and acetic anhydride is carried out with the above-mentioned apparatus, and includes the following steps. Isobutyric acid and acetic anhydride are reacted in the first reaction unit to obtain a first mixture, wherein the first mixture comprises isobutyric anhydride and acetic acid. The first mixture is introduced into the first purification unit to perform a first purification process on the first mixture to obtain isobutyric anhydride and acetic acid. The isobutyric anhydride is introduced into a cracking unit to perform a cracking process on the isobutyric anhydride to obtain a second mixture, wherein the second mixture comprises dimethylketene, isobutyric acid and isobutyric anhydride. The second mixture is introduced into a gas-liquid separation unit to perform a gas-liquid separation process on the second mixture to obtain dimethylketene gas and a liquid, wherein the liquid contains isobutyric acid and isobutyric anhydride. The liquid is introduced into the feed unit. According to an embodiment of the present disclosure, the method for preparing a compound using isobutyric acid and acetic anhydride may further include at least one of the following steps. Isobutyric acid and acetic anhydride were introduced from the feed unit into the first reaction unit. The resulting acetic acid is introduced into an acetic acid collection unit. A liquid comprising isobutyric acid and isobutyric anhydride is introduced from the feed unit to the first reaction unit to react the isobutyric acid and acetic anhydride in the liquid. The dimethylketene gas is introduced into a second reaction unit. Dimethylketene gas is dimerized in this second reaction unit to form 2,2,4,4-tetramethyl-1,3-cyclobutanedione. A jet suction process is performed on dimethylketene by a suction unit, so that the dimethylketene gas is introduced into the second reaction unit from the gas-liquid separation unit. A solvent supply unit is used to supply the suction unit with a solvent to perform the jet suction process. The 2,2,4,4-tetramethyl-1,3-cyclobutanedione and the solvent are mixed in a hydrogenation unit to obtain a solution, wherein the solid content of the solution is 5wt% to 20wt%. The solution is hydrogenated with hydrogen in the hydrogenation unit to obtain a third mixture, wherein the third mixture comprises 2,2,4,4-tetramethyl-1,3-cyclobutanediol, hydrogen, and solvent. The third mixture is introduced into a second purification unit to perform a second purification process on the third mixture to obtain 2,2,4,4-tetramethyl-1,3-cyclobutanediol, hydrogen, and a solvent . The solvent separated by the second purification process is recovered by the solvent supply unit. The hydrogen separated by the second purification process is introduced into the hydrogenation unit. The 2,2,4,4-tetramethyl-1,3-cyclobutanediol separated in the second purification process is introduced into a collection unit.

The method and apparatus for preparing compounds using isobutyric acid and acetic anhydride according to the present disclosure will be described in detail below. It should be appreciated that the following description provides many different embodiments or examples for implementing different aspects of the invention. The specific elements and arrangements described below are merely illustrative of the invention. Of course, these are only used as examples rather than limitations of the present invention. Furthermore, repeated reference numbers or designations may be used in different embodiments. These repetitions are for simplicity and clarity of description of the present invention and do not represent any association between the different embodiments and/or structures discussed.

It must be understood that the elements specifically described or illustrated may exist in various forms well known to those skilled in the art. The ordinal numbers such as "first", "second", "third", etc. used in the description and the claimed items are used to modify the elements of the claimed items, and they do not imply and represent that the claimed elements have any preceding elements. The ordinal numbers do not represent the order of a request element and another request element, or the order of the manufacturing method. The use of these ordinal numbers is only used to make a request element with a certain name and another request with the same name. Components can be clearly distinguished.

The present disclosure provides a method and apparatus for preparing compounds using isobutyric acid and acetic anhydride. According to an embodiment of the present disclosure, the compound prepared using isobutyric acid and acetic anhydride may be acetic acid, dimethylketene, 2,2,4,4-tetramethyl-1,3-cyclobutanedione, and or 2,2,4,4-Tetramethyl-1,3-cyclobutanediol. The method for preparing compounds using isobutyric acid and acetic anhydride in the present disclosure can be a continuous process, and the device for preparing compounds using isobutyric acid and acetic anhydride can be applied to the method for preparing compounds using isobutyric acid and acetic anhydride .

According to an embodiment of the present disclosure, the method and apparatus for preparing a compound using isobutyric acid and acetic anhydride described in the present disclosure may further include the preparation and cracking of isobutyric anhydride, and may further include dimerization of dimethylketene gas, and Hydrogenation of 2,2,4,4-tetramethyl-1,3-cyclobutanedione. According to the embodiments of the present disclosure, the method and device for preparing compounds using isobutyric acid and acetic anhydride described in the present disclosure can be used to obtain by-products (such as isobutyric acid) and unreacted starting materials (such as isobutyric anhydride) obtained after the cleavage of isobutyric anhydride. butyric anhydride) for reuse.

According to an embodiment of the present disclosure, the method and apparatus for preparing a compound using isobutyric acid and acetic anhydride described in the present disclosure can utilize a jet suction process to collect the obtained dimethylketene gas. Since the pressure difference of the jet suction process comes from the flow rate of the solvent, the dimethylketene gas can be collected at 5°C to 25°C and normal pressure (eg, 750 Torr to 770 Torr) to improve the dimethylketene gas. collection efficiency. The conventional technology is to collect liquid dimethyl ketene with a low temperature and low pressure liquid phase absorption process, so it is necessary to use low pressure (for example, less than 80 Torr) to reduce the boiling point of dimethyl ketene, and at low temperature (for example, less than -10 ℃) The dimethylketene was collected in the environment. Therefore, compared with the conventional low temperature and low pressure liquid phase absorption process, the present disclosure adopts the jet suction process to collect the dimethylketene gas, which not only greatly reduces energy consumption, but also reduces the loss of dimethylketene (ie increase the yield of dimethylketene).

According to an embodiment of the present disclosure, the method and apparatus for preparing a compound using isobutyric acid and acetic anhydride described in the present disclosure is to dimerize dimethylketene at a relatively low temperature (eg, below 75° C.) to form 2,2 ,4,4-tetramethyl-1,3-cyclobutanedione. In this way, the generation of by-products (eg, oligomers) can be reduced, and the selectivity of 2,2,4,4-tetramethyl-1,3-cyclobutanedione can be improved. According to the embodiment of the present disclosure, the selectivity of forming 2,2,4,4-tetramethyl-1,3-cyclobutanedione by dimerization can be as high as 96% or more.

According to an embodiment of the present disclosure, the method and apparatus for preparing a compound using isobutyric acid and acetic anhydride described in the present disclosure is a relatively low temperature (eg, lower than 80° C.) for 2,2,4,4-tetramethyl-1 , 3-cyclobutanedione was hydrogenated. In this way, the generation of by-products (eg, by-products of cyclic ketones, by-products of ring-opened ketones, or 2,2,4-trimethyl-1,3-pentanediol) can be greatly reduced. According to an embodiment of the present disclosure, the selectivity of forming 2,2,4,4-tetramethyl-1,3-cyclobutanediol by hydrogenation can be as high as 96% or more.

FIG. 1 is a flow chart showing the steps of a method 10 for preparing compounds using isobutyric acid and acetic anhydride according to an embodiment of the disclosure.

The method 10 of the present disclosure for preparing compounds using isobutyric acid and acetic anhydride includes the following steps. First, isobutyric acid and acetic anhydride are reacted (eg, esterification reaction) to obtain a first mixture (step 12), wherein the first mixture comprises isobutyric anhydride and acetic acid. According to an embodiment of the present disclosure, the isobutyric acid and the acetic anhydride may be thoroughly mixed before the reaction. Next, the first mixture obtained in step 12 is subjected to a first purification process to obtain isobutyric anhydride and acetic acid (step 14). According to an embodiment of the present disclosure, the first purification process may include a distillation process. According to an embodiment of the present disclosure, the first purification process may include a stirring process and a distillation process. Before subjecting the first mixture to the distillation process, the first mixture is subjected to a stirring process. According to an embodiment of the present disclosure, after the first purification process is performed, the acetic acid is collected. Next, a cracking process is performed on the isobutyric anhydride obtained in step 14 to obtain a second mixture, wherein the second mixture comprises dimethylketene, isobutyric acid and isobutyric anhydride (step 16). In the cracking process, the isobutyric anhydride can be preheated at 280°C to 350°C first, and then the isobutyric anhydride is heated to between 400°C and 500°C to thermally crack the isobutyric anhydride. According to an embodiment of the present disclosure, the pressure of the cracking process may be between 60 Torr and 120 Torr, the process time may be between 0.01 second and 1 second, and the conversion rate of isobutyric anhydride may be greater than or equal to 45%, For example between 45% and 70%. According to an embodiment of the present disclosure, the cracking process can be performed after mixing with a carrier gas (eg, argon or nitrogen) and isobutyric anhydride gas. Next, a gas-liquid separation process is performed on the second mixture obtained in step 16 to obtain dimethylketene gas and a liquid, wherein the liquid includes isobutyric acid and isobutyric anhydride (step 18).

According to an embodiment of the present disclosure, after the gas-liquid separation process is performed, the method 10 for preparing a compound using isobutyric acid and acetic anhydride described in the present disclosure may further include: collecting the liquid, and making isobutyric acid and acetic anhydride in the liquid React (step 20).

FIG. 2 is a flow chart of the steps of a method 50 for preparing compounds using isobutyric acid and acetic anhydride according to certain embodiments disclosed. According to an embodiment of the present disclosure, after the gas-liquid separation process is performed, the method 50 for preparing a compound using isobutyric acid and acetic anhydride in the present disclosure may further include: using a jet suction process at 5°C to 25°C and 750 Torr to The dimethylketene gas was collected at 770 Torr (step 22). The present disclosure adopts the jet suction process to collect the dimethyl ketene gas, which not only can greatly reduce the energy consumption (that is, the dimethyl ketene can be collected under normal pressure, and does not need to be cooled to below -10°C), it can also reduce the energy consumption of dimethyl ketene. Escaping of methyl ketene (ie increasing the yield of dimethyl ketene). According to an embodiment of the present disclosure, the pressure difference of the jet suction process comes from the flow rate of the solvent, and the solvent used may be an ester solvent, such as isobutyl isobutyrate, ethyl propionate, or octyl acetate. According to an embodiment of the present disclosure, during the jet suction process, the solvent can dissolve (absorb) dimethylketene to form an ester solution containing dimethylketene. According to an embodiment of the present disclosure, the dimethyl ketene concentration of the dimethyl ketene-containing ester solution may be 10 wt % to 40 wt %, based on the total weight of the dimethyl ketene and the solvent. According to an embodiment of the present disclosure, after collecting the dimethyl ketene gas (or forming an ester solution containing dimethyl ketene), the method 50 of the present disclosure for preparing a compound by using isobutyric acid and acetic anhydride may further include: : Dimerization of dimethyl ketene to obtain 2,2,4,4-tetramethyl-1,3-cyclobutanedione (2,2,4,4-Tetramethyl-1,3-cyclobutanedione) , TMCD) (step 24). According to an embodiment of the present disclosure, the temperature of the dimerization reaction can be controlled to be 20°C to 75°C. If the reaction temperature is too low, the reaction is too slow, and the reaction time needs to be increased. If the reaction temperature is too high, by-products (such as oligomers of polyester or polyketone) will be produced in the dimerization reaction, reducing 2,2,4,4-tetramethyl-1,3-cyclobutanedi Ketone yield and purity. For example, dimerization of dimethylketene at 75°C will increase the amount of polyester or polyketone oligomer by a factor of about 1.42 (compared to dimerization of dimethylketene at 70°C). compared to the amount of polyester or polyketone oligomers obtained from the polymerization). According to an embodiment of the present disclosure, the time of the dimerization reaction may be between 2 hours and 24 hours.

Furthermore, according to an embodiment of the present disclosure, the dimerization reaction can be performed in an environment of inert gas (eg, nitrogen or argon). According to an embodiment of the present disclosure, the dimerization reaction of dimethylketene can be carried out in the presence of a catalyst. The present disclosure does not limit the catalyst used, and it can be a conventional catalyst used for dimerization of dimethylketene. According to the embodiment of the present disclosure, if an ester solvent (eg, isobutyl isobutyrate) is used, the solubility of the ester solvent to 2,2,4,4-tetramethyl-1,3-cyclobutanedione is relatively low. , the 2,2,4,4-tetramethyl-1,3-cyclobutanedione formed after the dimerization reaction tends to precipitate out. Therefore, after the dimerization reaction is completed, a process (such as a recrystallization process and/or a filtration process) can be used to collect the solid 2,2,4,4-tetramethyl-1,3-cyclobutanedione, and use a solvent Washing is performed to obtain high-purity 2,2,4,4-tetramethyl-1,3-cyclobutanedione (purity can be greater than 99wt%).

According to an embodiment of the present disclosure, after the dimerization reaction of dimethyl ketene, the method 50 for preparing a compound using isobutyric acid and acetic anhydride described in the present disclosure may further include: combining the 2, 2, 4, 4-Tetramethyl-1,3-cyclobutanedione is mixed with a solvent to obtain a solution (step 26), and the solution obtained in step 26 is subjected to hydrogenation reaction with hydrogen to obtain a third mixture, wherein the third mixture is obtained. The trimix contains 2,2,4,4-tetramethyl-1,3-cyclobutanediol, hydrogen, and solvent (step 28). According to an embodiment of the present disclosure, the solid content of the solution may be 5 wt % to 20 wt %. According to an embodiment of the present disclosure, the solution containing 2,2,4,4-tetramethyl-1,3-cyclobutanedione can be hydrogenated with hydrogen in the presence of a catalyst to form 2,2, 4,4-Tetramethyl-1,3-cyclobutanediol (2,2,4,4-Tetramethyl-1,3-cyclobutanediol, CBDO). The present disclosure does not limit the catalyst used, and it can be a conventional catalyst used for hydrogenation of 2,2,4,4-tetramethyl-1,3-cyclobutanedione. According to an embodiment of the present disclosure, the hydrogen pressure of the hydrogenation reaction may be between 10 bar and 120 bar, for example, between 30 bar and 70 bar. According to an embodiment of the present disclosure, the temperature of the hydrogenation reaction may be 50° C. to 80° C., and the pressure of the hydrogenation reaction may be 1 MPa to 10 MPa. Table 1 shows the selectivity of each product obtained by hydrogenation of 2,2,4,4-tetramethyl-1,3-cyclobutanedione at 60°C and 135°C respectively (other reaction conditions are the same).

Table 1 Hydrogenation reaction temperature Selectivity (%) CBDO Cyclic ketone products Ring-opened ketone products TMPD 135℃ 89.9 0.26 7.5 2.4 60℃ 99.2 0.14 0.06 0

It can be seen from Table 1 that although the hydrogenation rate increases as the temperature rises, if the temperature of the hydrogenation process is too high, by-products (cyclic ketone products, ring-opening ketone products, or 2,2,4- The ratio of trimethyl-1,3-pentanediol (2,2,4-Trimethyl-1,3-pentanediol, TMPD).

According to an embodiment of the present disclosure, after the hydrogenation reaction of 2,2,4,4-tetramethyl-1,3-cyclobutanedione, the method for preparing a compound using isobutyric acid and acetic anhydride described in the present disclosure 50 It may further comprise: performing a second purification process on the third mixture to obtain 2,2,4,4-tetramethyl-1,3-cyclobutanediol (step 30). According to an embodiment of the present disclosure, the second purification process may include a phase separation process to recover hydrogen and obtain a solution comprising 2,2,4,4-tetramethyl-1,3-cyclobutanediol and a solvent . According to an embodiment of the present disclosure, the second purification process may further include a distillation process to recover the solvent and remove by-products (cyclic ketone by-products, ring-opened ketone by-products) to obtain 2,2,4,4-tetrakis Methyl-1,3-cyclobutanediol.

According to an embodiment of the present disclosure, the present disclosure also provides an apparatus for preparing a compound by using isobutyric acid and acetic anhydride. FIG. 3 is a schematic diagram of the apparatus 100 for preparing compounds using isobutyric acid and acetic anhydride according to the disclosed embodiment.

As shown in FIG. 3, the apparatus 100 for preparing compounds using isobutyric acid and acetic anhydride may include a feeding unit 110, a first reaction unit 115, a first purification unit 120, a cracking unit 125, and a gas-liquid Separation unit 130 . The feed unit 110 is connected with the first reaction unit 115 to introduce isobutyric acid and acetic anhydride from the feed unit 110 into the first reaction unit 115 . In the first reaction unit 115, the isobutyric acid reacts with acetic anhydride in the first reaction unit to obtain a first mixture, wherein the first mixture comprises isobutyric anhydride and acetic acid. According to an embodiment of the present disclosure, the first reaction unit 115 may be, for example, a continuous stirred reactor. The first reaction unit 115 is connected to the first purification unit 120 to introduce the first mixture into the first purification unit 120 . The first mixture can be subjected to a first purification process in the first purification unit to obtain isobutyric anhydride and acetic acid. According to an embodiment of the present disclosure, the first purification unit 120 may include a distillation column. The first purification unit 120 is connected to the cleavage unit 125 to introduce isobutyric anhydride into the cleavage unit 125 . The isobutyric anhydride undergoes a cracking process in the cracking unit to obtain a second mixture, wherein the second mixture comprises dimethylketene, isobutyric acid and isobutyric anhydride. According to an embodiment of the present disclosure, the cracking unit 125 may include an evaporator and a cracking reactor (not shown). The isobutyric anhydride supplied by the purification unit 120 is preheated by the evaporator and then introduced into the cracking reactor for high temperature cracking reaction. The cracking unit 125 is connected with the gas-liquid separation unit 130 to introduce the second mixture into the gas-liquid separation unit 130, wherein the second mixture is separated into a dimethylketene gas and a liquid in the gas-liquid separation unit 130, The liquid contains isobutyric acid and isobutyric anhydride, wherein the feeding unit 110 is connected with the gas-liquid separation unit 130 to introduce the liquid into the feeding unit 110 . According to an embodiment of the present disclosure, the feeding unit 110 may further introduce the liquid into the first reaction unit 115 to react with acetic anhydride. According to an embodiment of the present disclosure, the apparatus 100 for preparing compounds using isobutyric acid and acetic anhydride may further include an acetic acid collection unit 135, wherein the acetic acid collection unit 135 is connected to the first purification unit 120 for collecting the first purification Acetic acid separated by unit 120.

FIG. 4 is a schematic diagram of an apparatus 200 for preparing compounds using isobutyric acid and acetic anhydride according to the disclosed embodiment. According to the disclosed embodiments, the apparatus for preparing compounds using isobutyric acid and acetic anhydride described in the disclosed embodiments is except the feeding unit 110 , the first reaction unit 115 , the first purification unit 120 , the cracking unit 125 , and the In addition to the gas-liquid separation unit 130, it may further include a second reaction unit 140, a suction unit 145, a solvent supply unit 150, a solid-liquid separation unit 155, a hydrogenation unit 160, a second purification unit 165, and At least one of a collection unit 170 .

According to an embodiment of the present disclosure, as shown in FIG. 4 , in order to dimerize dimethylketene to form 2,2,4,4-tetramethyl-1,3-cyclobutanedione, the gas-liquid The separation unit 130 may be connected with the second reaction unit 140 to introduce the dimethylketene gas into the second reaction unit 140 . The dimethylketene gas undergoes a dimerization reaction in the second reaction unit 140 to form 2,2,4,4-tetramethyl-1,3-cyclobutanedione.

According to the embodiment of the present disclosure, in order to enable the second reaction unit 140 to sufficiently receive the dimethylketene gas obtained by the gas-liquid separation unit 130 at 5° C. to 25° C. and normal pressure (eg, 750 Torr to 770 Torr), The apparatus 200 for preparing compounds using isobutyric acid and acetic anhydride described in the present disclosure may further include a suction unit 145 . The second reaction unit 140 is connected to the gas-liquid separation unit 130 through the suction unit, wherein the suction unit 145 can perform a jet suction process for the dimethylketene gas, so that the gas-liquid separation unit 130 The separated dimethylketene gas may be received by the second reaction unit 140 .

According to an embodiment of the present disclosure, the apparatus 200 for preparing compounds using isobutyric acid and acetic anhydride described in the present disclosure may further include a solvent supply unit 150, wherein the solvent supply unit 150 is connected to the suction unit 145 for supplying the suction Unit 145-solvent performs the jet pumping process. During the jet suction process, the solvent can dissolve (absorb) dimethylketene to form an ester solution containing dimethylketene. According to an embodiment of the present disclosure, the dimethylketene gas collected by the second reaction unit 140 can also be further dissolved in the solvent to form an ester solution containing dimethylketene.

According to an embodiment of the present disclosure, the second reaction unit 140 can perform a dimerization reaction on dimethylketene to obtain 2,2,4,4-tetramethyl-1,3-cyclobutanedione (2,2,4,4-tetramethyl-1,3-cyclobutanedione) , 2,4,4-Tetramethyl-1,3-cyclobutanedione, TMCD). According to an embodiment of the present disclosure, in the second reaction unit 140, the temperature of the dimerization reaction can be controlled between 20°C and 75°C, so as to reduce the generation of by-products (eg, oligomers) and increase the 2,2,4 ,4-tetramethyl-1,3-cyclobutanedione selectivity. According to an embodiment of the present disclosure, an inert gas (eg, nitrogen gas or argon gas) can be introduced into the second reaction unit 140, so that the dimerization reaction is performed in an inert gas environment. According to an embodiment of the present disclosure, the second reaction unit 140 may include a reactor (eg, a continuous stirring reactor) and a set of crystallizers (not shown). The dimethylketene supplied by the gas-liquid separation unit 130 undergoes a dimerization reaction through a stirring reactor, and the obtained 2,2,4,4-tetramethyl-1,3-cyclobutanedione (TMCD) is then passed through The crystallizer formed 2,2,4,4-tetramethyl-1,3-cyclobutanedione as a solid.

According to an embodiment of the present disclosure, the apparatus 200 for preparing compounds using isobutyric acid and acetic anhydride described in the present disclosure may further include a solid-liquid separation unit 155 , wherein the second reaction unit 140 is connected to the solid-liquid separation unit 155 to separate the The product (including solvent and 2,2,4,4-tetramethyl-1,3-cyclobutanedione solid) obtained by the second reaction unit 140 is introduced into the solid-liquid separation unit 155 . By the solid-liquid separation unit 155, 2,2,4,4-tetramethyl-1,3-cyclobutanedione can be separated from the solvent in solid form. According to an embodiment of the present disclosure, the solid-liquid separation unit 155 can be connected to the solvent supply unit 150 to recover the solvent by the solvent supply unit 150 . According to an embodiment of the present disclosure, the solvent supply unit 150 can purify the recovered solvent and reuse it.

According to an embodiment of the present disclosure, the apparatus 200 for preparing compounds using isobutyric acid and acetic anhydride described in the present disclosure may further include a hydrogenation unit 160, wherein the solid-liquid separation unit 155 is connected to the hydrogenation unit 160 to separate 2, 2, 4,4-Tetramethyl-1,3-cyclobutanedione is introduced into this hydrogenation unit 160 . According to an embodiment of the present disclosure, the solvent supply unit 150 can be connected with the hydrogenation unit to introduce the solvent into the hydrogenation unit 160. 2,2,4,4-tetramethyl-1,3-cyclobutanedione can be hydrogenated The unit 160 performs a hydrogenation reaction to obtain a third mixture, wherein the third mixture comprises 2,2,4,4-tetramethyl-1,3-cyclobutanediol, hydrogen, and a solvent. According to an embodiment of the present disclosure, the hydrogenation unit 160 may include a stirrer, a gas supplier, and a reactor. The stirrer can mix 2,2,4,4-tetramethyl-1,3-cyclobutanedione with the solvent to form a solution and introduce the solution into the reactor. The gas supply can provide gas (eg, hydrogen, or hydrogen and carrier gas) into the reactor such that 2,2,4,4-tetramethyl-1,3-cyclobutanedione in the presence of hydrogen The hydrogenation reaction is carried out in the reactor.

According to an embodiment of the present disclosure, the apparatus 200 for preparing a compound using isobutyric acid and acetic anhydride described in the present disclosure may further include a second purification unit 165, wherein the hydrogenation unit 160 is connected to the second purification unit 165 to connect the third The mixture is directed to the second purification unit 165 . The third mixture can be subjected to a purification process in the second purification unit to separate 2,2,4,4-tetramethyl-1,3-cyclobutanediol, hydrogen, and solvent. According to an embodiment of the present disclosure, the second purification unit 165 can be connected to the solvent supply unit 150 to recover the solvent by the solvent supply unit 150 . According to an embodiment of the present disclosure, the second purification unit 165 may introduce unreacted hydrogen into the hydrogenation unit 160 . According to an embodiment of the present disclosure, the second purification unit 165 may include a separator and a distillation column (not shown). The separator can separate gases (eg, comprising hydrogen, and carrier gas) and liquids (eg, comprising 2,2,4,4-tetramethyl-1,3-cyclobutanediol, solvent, and by-products), The gas is introduced into the hydrogenation unit 160, and the liquid is introduced into the distillation column. This distillation column can separate 2,2,4,4-tetramethyl-1,3-cyclobutanediol and the solvent from the liquid, and introduce the solvent into the solvent supply unit 150 . According to an embodiment of the present disclosure, the solvent supply unit may include a purification part and a storage part (not shown). The purification unit can purify the liquid recovered by the solid-liquid separation unit 155 and the second purification unit, so that the solvent can be introduced into the suction unit 145 and the hydrogenation unit 160 for reuse.

According to an embodiment of the present disclosure, the apparatus 200 for preparing compounds using isobutyric acid and acetic anhydride described in the present disclosure may further include a collection unit 170, wherein the collection unit 170 is connected to the second purification unit 165 for collecting 2, 2 ,4,4-tetramethyl-1,3-cyclobutanediol.

According to an embodiment of the present disclosure, the present disclosure provides a method for preparing a compound using isobutyric acid and acetic anhydride. The method for preparing the compound using isobutyric acid and acetic anhydride can be carried out using the apparatus shown in FIG. 3 or FIG. 4 . FIG. 5 is a flow chart showing the steps of a method 300 for preparing a compound using isobutyric acid and acetic anhydride according to an embodiment of the disclosure. The method 300 may be performed using the apparatus shown in FIG. 3 .

According to an embodiment of the present disclosure, the method 300 for preparing a compound using isobutyric acid and acetic anhydride described in the present disclosure includes the following steps. Isobutyric acid and acetic anhydride are introduced from the feed unit 110 into the first reaction unit 115 (step 310). Isobutyric acid and acetic anhydride are subjected to a reaction (eg, esterification) in the first reaction unit to obtain a first mixture, wherein the first mixture comprises isobutyric anhydride and acetic acid (step 320). According to an embodiment of the present disclosure, the isobutyric acid and the acetic anhydride may be thoroughly mixed before the reaction. Next, the first mixture is introduced into the first purification unit 120 to perform a first purification process on the first mixture to obtain isobutyric anhydride and acetic acid (step 330). According to an embodiment of the present disclosure, the first purification process may include a stirring process and a distillation process. Before subjecting the first mixture to the distillation process, the first mixture is subjected to a stirring process. According to an embodiment of the present disclosure, after the first purification process is performed, the acetic acid may be collected by an acetic acid collection unit 135 . Next, the isobutyric anhydride is introduced into a cracking unit 125 from the first purification unit 120 to perform a cracking process on the isobutyric anhydride to obtain a second mixture, wherein the second mixture includes dimethylketene, isobutyric acid and isobutyl anhydride (step 340). In the cracking process, the isobutyric anhydride can be preheated at 280°C to 350°C first, and then the isobutyric anhydride is heated to between 400°C and 500°C to thermally crack the isobutyric anhydride. According to an embodiment of the present disclosure, the pressure of the cracking process may be between 60 Torr and 120 Torr, the process time may be between 0.01 second and 1 second, and the conversion rate of isobutyric anhydride may be between 50% and 70%. %between. According to an embodiment of the present disclosure, the cracking process can be performed after mixing with a carrier gas (eg, argon or nitrogen) and isobutyric anhydride gas. Next, the second mixture is introduced into a gas-liquid separation unit 130 to perform a gas-liquid separation process on the second mixture to obtain dimethylketene gas and a liquid, wherein the liquid includes isobutyric acid and isobutyric anhydride (step 350 ) .

According to an embodiment of the present disclosure, after the gas-liquid separation process is performed, the method 300 for preparing a compound using isobutyric acid and acetic anhydride described in the present disclosure may further include: introducing the liquid into the feeding unit 110 (step 360 ). According to an embodiment of the present disclosure, the method 300 for preparing a compound using isobutyric acid and acetic anhydride described in the present disclosure may further include: introducing a liquid from the feeding unit 110 into the first reaction unit 115, so that the isobutyric acid in the liquid is introduced into the first reaction unit 115. The acid and acetic anhydride are reacted in the first reaction unit 115 .

FIGS. 6A and 6B are flow diagrams of the steps of a method 400 for preparing compounds using isobutyric acid and acetic anhydride according to certain embodiments disclosed. The method 400 may be performed using the apparatus shown in FIG. 4 .

According to an embodiment of the present disclosure, after the gas-liquid separation unit 130 performs a gas-liquid separation process on the second mixture, the method 400 for preparing a compound using isobutyric acid and acetic anhydride described in the present disclosure may include: using a suction unit 145. Perform a jet suction process on the dimethyl ketene gas to introduce the dimethyl ketene gas from the gas-liquid separation unit 130 into the second reaction unit 140 (step 410). Through the jet suction process, the second reaction unit described in the present disclosure can collect the dimethylketene gas in an environment of 5° C. to 25° C. and 750 Torr to 770 Torr (ie, normal pressure). According to an embodiment of the present disclosure, the pressure difference of the jet suction process comes from the flow rate of the solvent, and the solvent used may be an ester solvent, such as isobutyl isobutyrate, ethyl propionate, or octyl acetate. According to an embodiment of the present disclosure, during the jet suction process, the solvent can dissolve (absorb) dimethylketene to form an ester solution containing dimethylketene. According to an embodiment of the present disclosure, the dimethyl ketene concentration of the dimethyl ketene-containing ester solution may be 10 wt % to 70 wt %, based on the total weight of the dimethyl ketene and the solvent. According to an embodiment of the present disclosure, a solvent supply unit 150 can be connected to the suction unit 145 to supply the suction unit 145 with a solvent to perform the jet suction process. During the jet suction process, the solvent can dissolve (absorb) dimethylketene to form an ester solution containing dimethylketene. According to an embodiment of the present disclosure, the dimethylketene gas collected by the second reaction unit 140 can also be further dissolved in the solvent to form an ester solution containing dimethylketene.

According to an embodiment of the present disclosure, after introducing dimethyl ketene into the second reaction unit 140, the method 400 for preparing a compound by using isobutyric acid and acetic anhydride in the present disclosure may include: introducing dimethyl ketene gas in the second reaction unit 140. A dimerization reaction is performed in the second reaction unit 140 to form 2,2,4,4-tetramethyl-1,3-cyclobutanedione (step 420). According to an embodiment of the present disclosure, the temperature of the second reaction unit 140 can be controlled at 20°C to 75°C. In other words, the dimerization reaction is carried out at 20°C to 75°C. If the reaction temperature is too low, the reaction is too slow, and the reaction time needs to be increased. If the reaction temperature is too high, oligomers of polyester or polyketone will be produced in the dimerization reaction, reducing the yield and purity of 2,2,4,4-tetramethyl-1,3-cyclobutanedione . According to an embodiment of the present disclosure, the time of the dimerization reaction may be between 2 hours and 24 hours. In addition, according to an embodiment of the present disclosure, an inert gas (eg, nitrogen or argon) can be introduced into the second reaction unit 140, so that the dimerization reaction is performed in an inert gas environment. According to the embodiment of the present disclosure, if an ester solvent (eg, isobutyl isobutyrate) is used, the solubility of the ester solvent to 2,2,4,4-tetramethyl-1,3-cyclobutanedione is relatively low. , the 2,2,4,4-tetramethyl-1,3-cyclobutanedione formed after the dimerization reaction tends to precipitate out. Therefore, after the dimerization reaction is completed, a process (such as a recrystallization process and/or a filtration process) can be used to collect the solid 2,2,4,4-tetramethyl-1,3-cyclobutanedione, and use a solvent Washing is performed to obtain high-purity 2,2,4,4-tetramethyl-1,3-cyclobutanedione (purity can be greater than 96wt%).

According to an embodiment of the present disclosure, after the dimerization of dimethylketene, the method 400 for preparing a compound using isobutyric acid and acetic anhydride described in the present disclosure may include: a dimerization product (including 2, 2, 4,4-tetramethyl-1,3-cyclobutanedione and solvent) are introduced into a solid-liquid separation unit 155 from the second reaction unit 140 to perform a solid-liquid separation process (step 430). In detail, in the solid-liquid separation unit 155, the product of the dimerization reaction (including 2,2,4,4-tetramethyl-1,3-cyclobutanedione and solvent) can pass through the solid-liquid The separation process allows 2,2,4,4-tetramethyl-1,3-cyclobutanedione to be separated from the solvent in solid form. According to the embodiment of the present disclosure, the solid-liquid separation unit 155 can be connected to the solvent supply unit 150 , so the liquid separated by the solid-liquid separation unit 155 can be introduced into the solvent supply unit 150 for recovery, so that the solvent can be passed through the solvent supply unit 150 Purified and reused.

According to an embodiment of the present disclosure, after the solid-liquid separation process is performed, the method 400 for preparing a compound by using isobutyric acid and acetic anhydride in the present disclosure may further include: separating 2,2,4,4-tetramethyl-1,3 - Cyclobutanedione and solvent are introduced into a hydrogenation unit 160 and mixed to obtain a solution (step 440). Then, the obtained solution is hydrogenated by the hydrogenation unit 160 to obtain a third mixture, wherein the third mixture comprises 2,2,4,4-tetramethyl-1,3-cyclobutanediol, hydrogen , and a solvent (step 450). According to an embodiment of the present disclosure, the 2,2,4,4-tetramethyl-1,3-cyclobutanedione can be introduced into the hydrogenation unit 160 from the solid-liquid separation unit 155 , and the solvent can be supplied from the solvent supply unit 150 Introduced into the hydrogenation unit 160 . According to an embodiment of the present disclosure, a gas (eg, hydrogen, or hydrogen and a carrier gas) can be introduced into the hydrogenation unit 160, so that 2,2,4,4-tetramethyl-1,3-cyclobutanedione and hydrogen A hydrogenation reaction is carried out. The solids content of the solution may range from 5 wt% to 20 wt%. In addition, according to an embodiment of the present disclosure, the solution containing 2,2,4,4-tetramethyl-1,3-cyclobutanedione can be hydrogenated with hydrogen in the presence of a catalyst to form 2, 2,4,4-Tetramethyl-1,3-cyclobutanediol. According to an embodiment of the present disclosure, the hydrogen pressure of the hydrogenation reaction may be between 10 bar and 120 bar, for example, between 30 bar and 70 bar. According to an embodiment of the present disclosure, the temperature of the hydrogenation reaction may be 50° C. to 80° C., and the pressure of the hydrogenation reaction may be 1 MPa to 10 MPa. Since the hydrogenation reaction is carried out at a relatively low temperature, by-products such as cyclic ketone by-products, ring-opened ketone by-products, or 2,2,4-trimethyl-1,3-pentanediol can be greatly reduced ) generation.

According to an embodiment of the present disclosure, after the hydrogenation reaction is performed, the method 400 for preparing a compound using isobutyric acid and acetic anhydride described in the present disclosure may further include: introducing the third mixture into a second purification unit 165 for the third mixture A second purification process is performed to obtain 2,2,4,4-tetramethyl-1,3-cyclobutanediol, hydrogen, and a solvent (step 460). According to an embodiment of the present disclosure, the second purification process may include a phase separation process to recover hydrogen and obtain a solution comprising 2,2,4,4-tetramethyl-1,3-cyclobutanediol and a solvent . According to an embodiment of the present disclosure, the second purification process may further include a distillation process to recover the solvent and remove by-products (cyclic ketone by-products, ring-opened ketone by-products) to obtain 2,2,4,4-tetrakis Methyl-1,3-cyclobutanediol. According to an embodiment of the present disclosure, after the second purification process is performed, the solvent supply unit 150 can be used to recover the solvent separated by the second purification process, and the hydrogen separated by the second purification process can be recovered from the second purification process. The purification unit 165 is introduced into the second reaction unit 160 .

According to an embodiment of the present disclosure, after the second purification process is performed, the method 400 for preparing a compound using isobutyric acid and acetic anhydride described in the present disclosure may further include: - Tetramethyl-1,3-cyclobutanediol is introduced into a collection unit 170 (step 470).

Based on the above, the method and apparatus for preparing compounds using isobutyric acid and acetic anhydride described in the present disclosure can be used to obtain by-products (such as isobutyric acid) and unreacted starting materials (such as isobutyric anhydride) obtained after isobutyric anhydride is cleaved Reuse. In addition, the method and device for preparing compounds using isobutyric acid and acetic anhydride described in the present disclosure can utilize a jet suction process to collect the obtained dimethylketene gas, thereby greatly reducing energy consumption and improving the dimethylketene production rate. yield. Furthermore, according to an embodiment of the present disclosure, the method and device for preparing a compound using isobutyric acid and acetic anhydride described in the present disclosure are formed by dimerizing dimethyl ketene at a relatively low temperature (eg, below 75° C.). 2,2,4,4-Tetramethyl-1,3-cyclobutanedione. In this way, the generation of by-products (such as oligomers) can be reduced, and the selectivity of 2,2,4,4-tetramethyl-1,3-cyclobutanedione can be improved (according to the embodiment of the present disclosure, the selectivity can be as high as more than 99%). On the other hand, the method and apparatus for preparing compounds using isobutyric acid and acetic anhydride described in the present disclosure is a relatively low temperature (eg lower than 80°C) for 2,2,4,4-tetramethyl-1,3 - Cyclobutanedione undergoes hydrogenation. In this way, the generation of by-products (eg, by-products of cyclic ketones, by-products of ring-opened ketones, or 2,2,4-trimethyl-1,3-pentanediol) can be greatly reduced.

Although the present disclosure has been disclosed above with several embodiments, it is not intended to limit the present disclosure. Anyone with ordinary knowledge in the technical field may make any changes and modifications without departing from the spirit and scope of the present disclosure. Therefore, the scope of protection of this disclosure should be determined by the scope of the appended patent application.

10, 50, 300, 400: the method of utilizing isobutyric acid and acetic anhydride to prepare compound 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 310, 320, 330, 340, 350, 360, 410, 420, 430, 440, 450, 460, 470: Steps 100, 200: Device for preparing compounds using isobutyric acid and acetic anhydride 110: Feeding unit 115: The first reaction unit 120: The first purification unit 125: Cracking unit 130: Gas-liquid separation unit 135: Acetic acid collection unit 140: Second reaction unit 145: Suction unit 150: Solvent supply unit 155: Solid-liquid separation unit 160: Hydrogenation unit 165: Second purification unit 170: Collection Unit

FIG. 1 is a flow chart showing the steps of a method 10 for preparing compounds using isobutyric acid and acetic anhydride according to an embodiment of the disclosure. FIG. 2 is a flow chart of the steps of a method 50 for preparing compounds using isobutyric acid and acetic anhydride according to certain embodiments disclosed. FIG. 3 is a schematic diagram of an apparatus 100 for preparing compounds using isobutyric acid and acetic anhydride according to an embodiment of the disclosure. FIG. 4 is a schematic diagram of an apparatus 200 for preparing compounds using isobutyric acid and acetic anhydride according to certain embodiments of the disclosure. FIG. 5 is a flow chart of the steps of a method 300 for preparing compounds using isobutyric acid and acetic anhydride according to certain embodiments disclosed. Figures 6A and 6B are a flow diagram of the steps of a method 400 for preparing compounds using isobutyric acid and acetic anhydride according to certain embodiments disclosed.

10: Utilize isobutyric acid and acetic anhydride to prepare the method for compound

12, 14, 16, 18, 20: Steps

Claims (38)

A method of utilizing isobutyric acid and acetic anhydride to prepare a compound, comprising: reacting isobutyric acid and acetic anhydride to obtain a first mixture, wherein the first mixture comprises isobutyric anhydride and acetic acid; A first purification process is performed on the first mixture to obtain isobutyric anhydride and acetic acid; A cracking process is performed on isobutyric anhydride to obtain a second mixture, wherein the second mixture comprises dimethylketene, isobutyric acid and isobutyric anhydride; performing a gas-liquid separation process on the second mixture to obtain dimethylketene gas and a liquid, wherein the liquid comprises isobutyric acid and isobutyric anhydride; and The liquid was collected and the isobutyric acid in the liquid was reacted with acetic anhydride. The method for preparing a compound using isobutyric acid and acetic anhydride as described in claim 1, further comprising: After the first purification process, the acetic acid is collected. The method for preparing a compound using isobutyric acid and acetic anhydride as described in claim 1, further comprising: A jet suction process was used to collect the dimethylketene gas at 5°C to 25°C and 750 Torr to 770 Torr. The method for preparing a compound using isobutyric acid and acetic anhydride as described in claim 3, further comprising: The dimethylketene was subjected to a dimerization reaction to obtain 2,2,4,4-tetramethyl-1,3-cyclobutanedione. The method for preparing a compound using isobutyric acid and acetic anhydride as described in claim 4, wherein the temperature of the dimerization reaction is 20°C to 75°C. The method for preparing a compound using isobutyric acid and acetic anhydride as described in claim 4, further comprising: mixing the 2,2,4,4-tetramethyl-1,3-cyclobutanedione with a solvent to obtain a solution, wherein the solid content of the solution is 5 wt % to 20 wt %; and The solution is subjected to a hydrogenation reaction with hydrogen to obtain a third mixture, wherein the third mixture comprises 2,2,4,4-tetramethyl-1,3-cyclobutanediol, hydrogen, and a solvent. The method for preparing a compound using isobutyric acid and acetic anhydride according to claim 6, wherein the temperature of the hydrogenation reaction is 50°C to 80°C, and the pressure of the hydrogenation reaction is 1 MPa to 10 MPa. The method for preparing a compound using isobutyric acid and acetic anhydride as described in claim 6, further comprising: The third mixture is subjected to a second purification process to obtain 2,2,4,4-tetramethyl-1,3-cyclobutanediol. A device for preparing compounds using isobutyric acid and acetic anhydride, comprising: a feeding unit; A first reaction unit, wherein the feed unit is connected to the first reaction unit to introduce isobutyric acid and acetic anhydride from the feed unit to the first reaction unit, wherein the isobutyric acid is in the first reaction unit react with acetic anhydride to obtain a first mixture, wherein the first mixture comprises isobutyric anhydride and acetic acid; a first purification unit, wherein the first reaction unit is connected to the first purification unit to introduce the first mixture to the first purification unit, wherein the first mixture undergoes a first purification in the first purification unit process to obtain isobutyric anhydride and acetic acid; A cleavage unit, wherein the first purification unit is connected to the cleavage unit to introduce isobutyric anhydride into the cleavage unit, wherein the isobutyric anhydride undergoes a cleavage process in the cleavage unit to obtain a second mixture, wherein the second mixture Contains dimethylketene, isobutyric acid and isobutyric anhydride; and A gas-liquid separation unit, wherein the cracking unit is connected with the gas-liquid separation unit to introduce the second mixture into the gas-liquid separation unit, wherein the second mixture is separated into a dimethylketene gas in the gas-liquid separation unit and a liquid, wherein the liquid comprises isobutyric acid and isobutyric anhydride, wherein the feed unit is connected with the gas-liquid separation unit to introduce the liquid into the feed unit. The apparatus for preparing compounds using isobutyric acid and acetic anhydride as claimed in claim 9, wherein the feeding unit introduces the liquid into the first reaction unit to react with the acetic anhydride. The device for preparing compounds using isobutyric acid and acetic anhydride as described in claim 9, further comprising: An acetic acid collection unit, wherein the acetic acid collection unit is connected with the first purification unit for collecting the acetic acid obtained by the first purification unit. The device for preparing compounds using isobutyric acid and acetic anhydride as described in claim 9, further comprising: A second reaction unit, wherein the gas-liquid separation unit is connected to the second reaction unit to introduce the dimethyl ketene gas into the second reaction unit, wherein the dimethyl ketene gas is in the second reaction unit During the reaction, 2,2,4,4-tetramethyl-1,3-cyclobutanedione is formed. The device for preparing compounds using isobutyric acid and acetic anhydride as described in claim 12, further comprising: a suction unit, wherein the second reaction unit is connected with the gas-liquid separation unit through the suction unit, wherein the suction unit performs a jet suction process on the dimethylketene gas to make the second reaction The unit receives the dimethylketene gas at 5°C to 25°C and 750 Torr to 770 Torr. The device for preparing compounds using isobutyric acid and acetic anhydride as described in claim 13, further comprising: A solvent supply unit, wherein the solvent supply unit is connected with the suction unit to supply a solvent to the suction unit to perform the jet suction process. The device for preparing compounds using isobutyric acid and acetic anhydride as described in claim 14, further comprising: A solid-liquid separation unit, wherein the second reaction unit is connected to the solid-liquid separation unit to introduce the solvent and 2,2,4,4-tetramethyl-1,3-cyclobutanedione into the solid-liquid The separation unit separates the 2,2,4,4-tetramethyl-1,3-cyclobutanedione as a solid from the solvent. The apparatus for preparing a compound using isobutyric acid and acetic anhydride as claimed in claim 15, wherein the solid-liquid separation unit is connected to the solvent supply unit to recover the solvent using the solvent supply unit. The device for preparing compounds using isobutyric acid and acetic anhydride as described in claim 15, further comprising: A hydrogenation unit, wherein the solid-liquid separation unit is connected to the hydrogenation unit to introduce 2,2,4,4-tetramethyl-1,3-cyclobutanedione into the hydrogenation unit, wherein the solvent supply unit is connected to the hydrogenation unit A hydrogenation unit is connected to introduce a solvent into the hydrogenation unit, wherein the 2,2,4,4-tetramethyl-1,3-cyclobutanedione is reacted with a hydrogen gas in the presence of a solvent to obtain a third mixture wherein The third mixture contains 2,2,4,4-tetramethyl-1,3-cyclobutanediol, hydrogen gas, and a solvent. The device for preparing compounds using isobutyric acid and acetic anhydride as described in claim 17, further comprising: A second purification unit, wherein the hydrogenation unit is connected to the second purification unit to introduce a third mixture into the second purification unit, wherein the third mixture is subjected to a purification process in the second purification unit to obtain 2,2,4 , 4-tetramethyl-1,3-cyclobutanediol, hydrogen, and a solvent. The apparatus for preparing compounds using isobutyric acid and acetic anhydride as claimed in claim 18, wherein the second purification unit is connected to the solvent supply unit to recover the solvent using the solvent supply unit. The apparatus for preparing compounds using isobutyric acid and acetic anhydride as claimed in claim 18, wherein the second purification unit introduces the hydrogen into the hydrogenation unit. The device for preparing compounds using isobutyric acid and acetic anhydride as described in claim 18, further comprising: A collection unit, wherein the collection unit is connected with the second purification unit for collecting 2,2,4,4-tetramethyl-1,3-cyclobutanediol. A method of utilizing isobutyric acid and acetic anhydride to prepare a compound, the method is carried out using the device described in claim 9, comprising: reacting isobutyric acid and acetic anhydride in the first reaction unit to obtain the first mixture, wherein the first mixture comprises isobutyric anhydride and acetic acid; introducing the first mixture into the first purification unit to perform the first purification process on the first mixture to obtain isobutyric anhydride and acetic acid; The isobutyric anhydride is introduced into the cracking unit to perform a cracking process on the isobutyric anhydride to obtain the second mixture, wherein the second mixture comprises dimethylketene, isobutyric acid and isobutyric anhydride; introducing the second mixture into the gas-liquid separation unit to perform the gas-liquid separation process on the second mixture to obtain dimethylketene gas and a liquid, wherein the liquid comprises isobutyric acid and isobutyric anhydride; and The liquid is introduced into the feed unit. The method for preparing a compound using isobutyric acid and acetic anhydride as described in claim 22, further comprising: Isobutyric acid and acetic anhydride were introduced from the feed unit into the first reaction unit. The method for preparing a compound using isobutyric acid and acetic anhydride as described in claim 22, after performing the first purification process, further comprising: The resulting acetic acid is introduced into an acetic acid collection unit. The method for preparing a compound using isobutyric acid and acetic anhydride as described in claim 22, after performing the gas-liquid separation process, further comprising: The liquid is introduced from the feed unit to the first reaction unit to react isobutyric acid and acetic anhydride in the liquid. The method for preparing a compound using isobutyric acid and acetic anhydride as described in claim 22, after performing the gas-liquid separation process, further comprising: introducing the dimethylketene gas into a second reaction unit; and The dimethylketene gas is dimerized in the second reaction unit to form 2,2,4,4-tetramethyl-1,3-cyclobutanedione. The method for preparing a compound using isobutyric acid and acetic anhydride as described in claim 26, wherein the temperature of the dimerization reaction is 20°C to 75°C. The method for preparing a compound using isobutyric acid and acetic anhydride as described in claim 26, further comprising: A jet suction process is performed on dimethylketene by a suction unit, so that the dimethylketene gas is introduced into the second reaction unit from the gas-liquid separation unit. The method for preparing a compound using isobutyric acid and acetic anhydride as claimed in claim 28, wherein the second reaction unit receives the dimethylketene gas at 5°C to 25°C and 750 Torr to 770 Torr. The method for preparing a compound using isobutyric acid and acetic anhydride as described in claim 28, further comprising: A solvent supply unit is used to supply the suction unit with a solvent to perform the jet suction process. The method for preparing a compound using isobutyric acid and acetic anhydride as described in claim 30, further comprising: The solvent and the 2,2,4,4-tetramethyl-1,3-cyclobutanedione were introduced into the solid-liquid separation unit, and 2,2,4,4-tetramethyl-1,3- The cyclobutanedione is isolated from the solvent in solid form. The method for preparing a compound using isobutyric acid and acetic anhydride as described in claim 26, further comprising: The 2,2,4,4-tetramethyl-1,3-cyclobutanedione and a solvent are mixed in a hydrogenation unit to obtain a solution, wherein the solid content of the solution is 5wt% to 20wt% . The method for preparing a compound using isobutyric acid and acetic anhydride as described in claim 32, further comprising: The solution is hydrogenated with hydrogen in the hydrogenation unit to obtain a third mixture, wherein the third mixture comprises 2,2,4,4-tetramethyl-1,3-cyclobutanediol, hydrogen, and solvent. The method for preparing a compound using isobutyric acid and acetic anhydride as described in claim 33, wherein the temperature of the hydrogenation reaction is 50°C to 80°C, and the pressure of the hydrogenation reaction is 1 MPa to 10 MPa. The method for preparing a compound using isobutyric acid and acetic anhydride as described in claim 33, further comprising: The third mixture is introduced into a second purification unit to perform a second purification process on the third mixture to obtain 2,2,4,4-tetramethyl-1,3-cyclobutanediol, hydrogen, and solvent. The method for preparing a compound using isobutyric acid and acetic anhydride as described in claim 35, further comprising: The solvent separated by the second purification process is recovered by the solvent supply unit. The method for preparing a compound using isobutyric acid and acetic anhydride as described in claim 34, further comprising: The hydrogen separated by the second purification process is introduced into the hydrogenation unit. The method for preparing a compound using isobutyric acid and acetic anhydride as described in claim 34, further comprising: The 2,2,4,4-tetramethyl-1,3-cyclobutanediol separated in the second purification process is introduced into a collection unit.

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