TW202224676A - Composition for external use on skin - Google Patents

Abstract

Provided is a composition for external use on skin, which can be packed in a container easily in the production thereof and is configured such that a proper amount can be discharged upon the application onto the skin. A composition for external use on skin is produced, which has good wettability on a polyolefin resin. The composition for external use on skin is prepared, the composition for external use on skin comprising (A) at least one component selected from the group consisting of ascorbic acid and an ascorbic acid salt and (B) a lower alcohol, and the composition for external use on skin being packed in a container in which a portion or the whole of a face that comes into contact with the composition for external use on skin comprises a resin containing a polyolefin.

Description

Composition for external use on skin and method for imparting wettability-improving effect to resin containing polyolefin to composition for external use on skin

The present invention relates to a composition for external use on skin. More specifically, it relates to a skin external composition containing ascorbic acid and/or a salt of ascorbic acid and a lower alcohol, collected in a specific container.

Ascorbic acid is known to exert anti-inflammatory effect, acne improvement effect, whitening effect, anti-aging effect, antioxidant effect, cell activation effect by promoting the synthesis of active ingredients such as collagen, inhibition of epidermal keratinocyte cells caused by ultraviolet rays Various effects, such as the effect of blocking or DNA (DeoxyriboNucleic Acid; deoxyribonucleic acid) damage, are expected to be used as an external preparation for skin. Such ascorbic acid is provided in the form containing a vehicle (for example, patent document 1). [Prior Art Literature] [Patent Literature]

[Patent Document 1] Japanese Patent Laid-Open No. 2005-225865.

[The problem to be solved by the invention]

An object of the present invention is to provide a composition for external use on skin which can be easily put into a container during manufacture and can be easily discharged in an appropriate amount when applied to the skin. [means to solve the problem]

According to the research by the inventors of the present application, when the composition for external use on skin is collected in a container containing a polyolefin resin, if the composition for external use on skin has poor wettability with respect to the container, it is easy to get rid of the external skin composition in the filling of the tube at the time of manufacture. Fine water droplets remain on the upper wall surface, which hinders the sealing of the container, and also makes it difficult to discharge an appropriate amount during use.

The inventors of the present application have repeatedly conducted intensive research in order to solve this problem, and found that by containing (A) at least one selected from the group consisting of ascorbic acid and salts of ascorbic acid; and (B) a lower alcohol, it is possible to The present invention has been accomplished by providing the composition with the effect of improving the wettability to the polyolefin-containing resin, the effect of suppressing the pH change due to storage, and the effect of promoting the defoaming.

That is, the present invention provides the skin external composition disclosed below. Item 1. A composition for external use on skin, comprising (A) at least one selected from the group consisting of ascorbic acid and salts of ascorbic acid; and (B) a lower alcohol; a part collected on the surface of the composition for external use on skin or All are containers containing polyolefin-containing resins. Item 2. The composition for external use on skin according to the item 1, wherein the total content of the component (B) is 1 to 7% by mass. Item 3. The composition for external use on skin according to any one of Items 1 or 2, which further contains a composition selected from the group consisting of (C-1), (C-2), (C-3), and (C-4) below. At least one of the group consisting of: (C-1) pyridoxine and/or a salt of pyridoxine; (C-2) selected from salicylic acid, derivatives of salicylic acid, and the aforementioned salicylic acid At least one selected from the group consisting of salts of the aforementioned derivatives of salicylic acid; (C-3) isopropyl methylphenol; (C-4) ascorbic acid derivatives. Item 4. The composition for external use on skin according to any one of Items 1 to 3, wherein the component (B) contains at least ethanol. Item 5. The composition for external use on skin according to any one of items 1 to 4, wherein the total content of the component (A) is 0.5% by mass to 30% by mass. Item 6. The skin external composition according to any one of Items 1 to 5, wherein the container is a tube type, a pouch pack, or a cheer pack.

Furthermore, the present invention provides the following method. Item 7. A method of imparting a wettability-improving effect, by causing (A) at least one selected from the group consisting of ascorbic acid and ascorbic acid salts in the composition; Provides a wettability-improving effect to resins containing polyolefins. [Inventive effect]

According to the present invention, it is possible to provide a composition for external use on skin which has good wettability to resin containing polyolefin and is stable.

In this specification, the unit of content "mass %" and "g/100g" have the same meaning.

[Composition for external use on skin] The skin external composition of the present invention contains: (A) at least one selected from the group consisting of ascorbic acid and ascorbic acid salts; and (B) lower alcohols; A part or the whole is a container containing a resin containing polyolefin.

[(A) at least one selected from the group consisting of ascorbic acid and salts of ascorbic acid] As the ascorbic acid used in the present invention, ascorbic acid used as a component of external preparations for skin in the field of pharmaceuticals, quasi-drugs, and cosmetics can be used. These ascorbic acids are not limited, but generally refer to the L-form.

Salts of ascorbic acid may also be used. Here, the so-called ascorbic acid salt is a pharmaceutically acceptable salt. Not limited, for example: salts with organic bases (such as trimethylamine salts, triethylamine salts, monoethanolamine salts, triethanolamine salts, pyridine salts, etc. and salts with tertiary amines; arginine salts) (such as basic ammonium salts, etc.), salts with inorganic bases (such as alkali metal salts such as ammonium salts, sodium salts, potassium salts; alkaline earth metal salts such as calcium salts, magnesium salts; aluminum salts, etc.) and the like. Preferred ascorbic acid salts are sodium salt and potassium salt.

In the present invention, ascorbic acid or its salt may be used alone or in combination of two or more. From the viewpoint of remarkably exerting the effects of the present invention, ascorbic acid is preferred. (A) Ascorbic acid or its salt may be synthesized and used, or a commercial item may be used.

In the skin external composition of the present invention, the total content of the component (A) can be appropriately set according to the balance with other components with respect to the total amount of the skin external composition. The total content of the component (A) is preferably 30% by mass or less, more preferably 10% by mass or less, still more preferably 9% by mass or less, and still more preferably 5% by mass or less with respect to the total amount of the composition for external use on the skin. . The total content of the component (A) is preferably 0.5% by mass or more, more preferably 1% by mass or more, more preferably 2% by mass or more, and still more preferably 3% by mass or more with respect to the total amount of the composition for external use on the skin . The total content of the component (A) is preferably 0.5% by mass to 30% by mass, more preferably 1% by mass to 10% by mass, and still more preferably 2% by mass to 9% by mass relative to the total amount of the composition for external use on skin , more preferably 3 to 5 mass %, 1 to 5 mass %, 1 to 3 mass %, 3 to 5 mass %, and 3 mass %.

[(B) Lower alcohol] The lower alcohol used in the present invention is not particularly limited as long as it is a component that can be used as an external preparation for skin in the fields of pharmaceuticals, quasi-drugs, or cosmetics. In this specification, when referring to "lower alcohol", it means a C ₁ -C ₆ alcohol, and among them, a C ₁ -C ₃ alcohol can be preferably used. As such an example, methanol, ethanol, n-propanol, isopropanol, etc. are mentioned. Furthermore, it is especially preferable that the lower alcohol used in the present invention contains at least ethanol, or is ethanol.

In the skin external composition of the present invention, the total content of the component (B) is preferably 0.1 to 20 mass %, more preferably 0.5 to 10 mass %, relative to the total amount of the skin external composition, and More preferably, it is 0.5 mass % to 7 mass %, More preferably, it is 1 mass % to 7 mass %, Especially preferably, it is 1 mass % to 5 mass %. In addition, 0.5 mass % to 5 mass %, 0.5 mass % to 3 mass %, 2 mass % to 5 mass %, 2 mass % to 3 mass %, etc. may be sufficient.

In addition, although not limited, typically, in the skin external composition of the present invention, the amount of ethanol is preferably 0.1 to 20 mass %, more preferably 0.5 mass % with respect to the total amount of the skin external composition. % to 10% by mass, still more preferably 1% to 7% by mass.

In the skin external composition of the present invention, the ratio of the compounding amount of the (B) component to the (A) component is preferably 0.003 to 40 parts by mass relative to 1 part by mass of the total content of the (A) component , more preferably 0.05 to 10 parts by mass, still more preferably 0.2 to 2.5 parts by mass.

The skin external composition of the present invention may further contain (C-1), (C-2), (C-3), and (C) selected from the group consisting of the following components in addition to the components (A) and (B) described above. -4) At least one of the groups formed. (C-1) Pyridoxine and/or a pyridoxine salt. (C-2) At least one selected from the group consisting of salicylic acid, derivatives of salicylic acid, and salts of the aforementioned salicylic acid and the aforementioned derivatives of salicylic acid. (C-3) Isopropylmethylphenol. (C-4) Ascorbic acid derivatives.

[(C-1) Pyridoxine and/or Pyridoxine Salt] The pyridoxine and/or the pyridoxine salt used in the present invention is not particularly limited as long as it can be used as an external preparation for skin in the fields of pharmaceuticals, quasi-drugs, or cosmetics.

The so-called pyridoxine salt means a pharmaceutically acceptable salt. Although not limited, for example, pyridoxine hydrochloride can be exemplified.

In the present invention, pyridoxine or its salt may be used alone or in combination of two or more. Pyridoxine hydrochloride is preferred from the viewpoint of remarkably exerting the effect of the present invention. Pyridoxine or its salt may be synthesized and used, or a commercial item may be used.

In the skin external composition of the present invention, the total content of the component (C-1) is not limited, but is preferably 0.001% by mass or more, more preferably 0.005% by mass or more, relative to the total amount of the skin external composition. More preferably, it is 0.01 mass % or more. The total content of the component (C-1) is not limited, but is preferably 1 mass % or less, more preferably 0.5 mass % or less, and even more preferably 0.1 mass % or less with respect to the total amount of the skin external composition.

The total content of the component (C-1) is preferably from 0.001% by mass to 1% by mass, preferably from 0.005% by mass to 0.5% by mass, and more preferably from 0.01% by mass to 0.1% by mass relative to the total amount of the composition for external use on skin quality%.

In the skin external composition of the present invention, the ratio of the compounding amount of the component (C-1) to the component (A) is not particularly limited, but is preferably 0.00003 mass with respect to the total content of the component (A) 1 part by mass part to 2 parts by mass, more preferably 0.0005 part by mass to 0.5 part by mass, still more preferably 0.002 part by mass to 0.04 part by mass.

[(C-2) At least one selected from the group consisting of salicylic acid, derivatives of salicylic acid, and salts of the aforementioned salicylic acid and derivatives of the aforementioned salicylic acid] The salicylic acid, derivatives of salicylic acid, and salts of the aforementioned salicylic acid and the aforementioned derivatives of salicylic acid used in the present invention can be used as skins in the fields of pharmaceuticals, quasi-drugs, or cosmetics. The composition of the external preparation is not particularly limited.

The derivatives of salicylic acid are not limited, but include, for example, ethylene glycol salicylate, phenyl salicylate, methyl salicylate, 2-ethylhexyl salicylate, and dipropylene glycol salicylate. , titanium salicylate, etc.

Here, the so-called salts of salicylic acid or derivatives of salicylic acid are pharmaceutically acceptable salts. Not limited, for example, alkali metal salts, alkaline earth metal salts, salts with organic bases, and the like can be exemplified. Examples of the salicylate include at least one selected from the group consisting of sodium salicylate, calcium salicylate, magnesium salicylate, and potassium salicylate.

In the present invention, salicylic acid, derivatives of salicylic acid, and salts of the aforementioned salicylic acid and the aforementioned derivatives of salicylic acid may be used alone or in combination of two or more. From the viewpoint of significantly exerting the effect of the present invention, it is preferably at least one selected from the group consisting of salicylic acid, sodium salicylate, calcium salicylate, magnesium salicylate and potassium salicylate, and more Preferably salicylic acid and/or sodium salicylate. Salicylic acid, derivatives of salicylic acid, and salts of the above-mentioned salicylic acid and the above-mentioned derivatives of salicylic acid may be synthesized and used, or commercial products may be used.

In the skin external composition of the present invention, the total content of the component (C-2) is not limited to the total amount of the skin external composition, but is preferably 0.00002 mass % or more, more preferably 0.0005 mass % or more, and More preferably, it is 0.05 mass % or more. The total content of the component (C-2) is not limited to the total amount of the composition for external use on the skin, but is preferably 5% by mass or less, more preferably 1% by mass or less, still more preferably 0.5% by mass or less, and still more. Preferably it is 0.2 mass % or less.

The total content of the component (C-2) is preferably 0.00002 to 5% by mass, preferably 0.0005 to 1% by mass, and more preferably 0.05 to 0.5% by mass relative to the total amount of the composition for external use on skin quality%.

In the skin external composition of the present invention, the ratio of the compounding amount of the component (C-2) to the component (A) is not particularly limited, but is preferably 0.0000006 mass with respect to 1 part by mass of the total content of the component (A) part to 10 parts by mass, more preferably 0.00005 part by mass to 1 part by mass, still more preferably 0.01 part by mass to 0.2 part by mass.

[(C-3)Isopropylmethylphenol] The isopropylmethylphenol used in the present invention is not particularly limited as long as it is a component that can be used as an external preparation for skin in the fields of pharmaceuticals, quasi-drugs, or cosmetics. Isopropylmethylphenol has a bactericidal effect.

Isopropylmethylphenol may be synthesized and used, or a commercial item may be used.

In the skin external composition of the present invention, the content of the component (C-3) is not limited, but is preferably 0.001 mass % or more, more preferably 0.005 mass % or more, relative to the total amount of the skin external composition. Preferably it is 0.01 mass % or more. Although content of (C-3) component is not limited with respect to the total amount of skin external composition, 5 mass % or less is preferable, 1 mass % or less is more preferable, and 0.1 mass % or less is more preferable.

The content of component (C-3) is preferably 0.001 to 5% by mass, preferably 0.005 to 1% by mass, and more preferably 0.01 to 0.1% by mass relative to the total amount of the composition for external use on skin %.

In the skin external composition of the present invention, the ratio of the compounding amount of the component (C-3) to the component (A) is not particularly limited, but is preferably 0.00003 mass with respect to 1 part by mass of the total content of the component (A) part to 10 parts by mass, more preferably 0.0005 part by mass to 1 part by mass, still more preferably 0.002 part by mass to 0.04 part by mass.

[(C-4)Ascorbic acid derivatives] The ascorbic acid derivative used in the present invention is not particularly limited as long as it is a component that can be used as an external preparation for skin in the fields of pharmaceuticals, quasi-drugs, or cosmetics. Examples include: 3-O-ethylascorbic acid, L-ascorbic acid 2-glucoside, tetrakis(2-hexyldecanoic acid) ascorbate, dehydroascorbic acid, sodium ascorbyl phosphate, magnesium ascorbyl phosphate, sodium ascorbyl monophosphate , sodium ascorbic acid diphosphate, sodium ascorbic acid triphosphate, sodium ascorbic acid-2-sulfate, or the salts of these ascorbic acid derivatives.

Here, the so-called salt refers to a pharmaceutically acceptable salt. Not limited, for example: salts with organic bases (such as trimethylamine salts, triethylamine salts, monoethanolamine salts, triethanolamine salts, pyridinium salts, etc. and salts with tertiary amines; arginine, etc. (such as alkaline ammonium salts, etc.), salts with inorganic bases (such as alkali metal salts such as ammonium salts, sodium salts, potassium salts; alkaline earth metal salts such as calcium salts, magnesium salts; aluminum salts, etc.) and the like. Particularly preferred salts of 3-O-ethyl ascorbic acid are sodium salt and potassium salt.

In the present invention, one type of ascorbic acid derivative may be used, or two or more types may be used in combination. From the viewpoint of remarkably exerting the effect of the present invention, 3-O-ethylascorbic acid or L-ascorbic acid 2-glucoside is preferable. The ascorbic acid derivative may be synthesized and used, or a commercial item may be used.

In the skin external composition of the present invention, the total content of the component (C-4) is preferably 0.0001 to 10 mass %, more preferably 0.0005 to 5 mass %, relative to the total amount of the skin external composition. , and more preferably 0.001% by mass to 2% by mass. It may be 0.0001 mass % to 2 mass %.

In the skin external composition of the present invention, the ratio of the compounding amount of the component (C-4) to the component (A) is not particularly limited, but is preferably 0.00005 mass with respect to 1 part by mass of the total content of the component (A) parts to 5 parts by mass, more preferably 0.0002 to 0.7 parts by mass.

[Polyol] The skin external composition of the present invention may contain a polyhydric alcohol in addition to the above-mentioned (A) component and (B) component, as long as the effect of the present invention is not inhibited.

The polyhydric alcohol used in the present invention is not particularly limited as long as it is a component that can be used as an external preparation for skin in the fields of pharmaceuticals, quasi-drugs, or cosmetics. Although the polyol is not limited, it may be added for moisturizing or as a cosolvent. A preferable polyol is a diol having 3 carbon atoms, but it is not limited. Other examples include glycerin, diglycerol, dipropylene glycol, 1,3-butanediol, 3-methyl-1,3-butanediol, and the like. In the present invention, one type of polyol may be used or two or more types may be used in combination.

With respect to the total amount of the skin external composition of the present invention, when the total content of the polyol is contained, it is preferably 0.1% by mass to 60% by mass, more preferably 1% by mass to 50% by mass, and still more preferably 10% by mass to about 45% by mass.

In the skin external composition of the present invention, the ratio of the polyol to component (A) is not particularly limited, but is preferably 0.003 to 120 parts by mass relative to 1 part by mass of the total content of component (A) parts, more preferably 0.1 to 50 parts by mass, still more preferably 2 to 15 parts by mass.

[Diol with 3 carbon atoms] The diol having 3 carbon atoms used in the present invention is not particularly limited as long as it is a component that can be used as an external preparation for skin in the fields of pharmaceuticals, quasi-drugs, or cosmetics. In addition, such a diol having 3 carbon atoms can also be used as a commercial item as it is. The diol having 3 carbon atoms is not limited, and for example, 1,3-propanediol (CAS (Chemical Abstracts Service; Chemical Abstracts Service) number: 504-63-2, English name: 1,3-Dihydroxypropane or Trimethylene Glycol) or propylene glycol (CAS number: 57-55-6, English name: 1,2-Dihydroxypropane, Chinese alias: 1,2-propanediol), either one or a suitable combination can be used. A combination of 1,3-propanediol and 1,2-propanediol is also one of the preferred embodiments, and as the diol having 3 carbon atoms, it is more preferable to include at least 1,3-propanediol.

In the skin external composition of the present invention, the total content of diols having 3 carbon atoms is 1 mass % or more, preferably 5 mass % or more, more preferably 10 mass %, relative to the total amount of the skin external composition. %above. The total content of the diols having 3 carbon atoms is 50 mass % or less, preferably 40 mass % or less, and more preferably 30 mass % or less with respect to the total amount of the skin external composition.

The total content of the diols having 3 carbon atoms is 1% by mass to 50% by mass, preferably 5% by mass to 40% by mass, and more preferably 10% by mass to 30% by mass relative to the total amount of the composition for external use on skin. quality%.

In the skin external composition of the present invention, the ratio of the diol having 3 carbon atoms to the compounding amount of the component (A) is not particularly limited, but is preferably 1 part by mass relative to the total content of the component (A). 0.003 to 120 parts by mass, more preferably 0.1 to 50 parts by mass, still more preferably 2 to 15 parts by mass.

The compounding amount of 1,2-propanediol in the diols having 3 carbon atoms is preferably 1 mass % or more, more preferably 5 mass % or more, and still more preferably 10 mass % with respect to the total amount of the skin external composition. %above. 40 mass % or less is preferable, 30 mass % or less is more preferable, 20 mass % or less is still more preferable, and 10 mass % or less is further more preferable.

The total content of 1,2-propanediol is 1 to 40% by mass, preferably 5 to 30% by mass, and more preferably 10 to 20% by mass relative to the total amount of the skin external composition.

In the skin external composition of the present invention, the ratio of 1,2-propanediol to the compounding amount of component (A) is not particularly limited, but is preferably 0.03 part by mass relative to 1 part by mass of the total content of component (A) To 80 parts by mass, more preferably from 0.5 to 30 parts by mass, still more preferably from 1 to 10 parts by mass, still more preferably from 2 to 7 parts by mass.

Among the diols having 3 carbon atoms, the compounding amount of 1,3-propanediol is preferably 1 mass % or more, more preferably 5 mass % or more, and still more preferably 10 mass % with respect to the total amount of the skin external composition. mass % or more. The compounding quantity of 1,3-propanediol is 30 mass % or less, More preferably, it is 25 mass % or less, More preferably, it is 20 mass % or less, More preferably, it is 15 mass % or less.

The total content of 1,3-propanediol is 1 to 30% by mass, preferably 5 to 20% by mass, and still more preferably 10 to 15% by mass relative to the total amount of the composition for external use on skin.

In the skin external composition of the present invention, the ratio of 1,3-propanediol to the compounding amount of component (A) is not particularly limited, but is preferably 0.03 part by mass relative to 1 part by mass of the total content of component (A) to 60 parts by mass, more preferably 0.5 to 20 parts by mass, still more preferably 1 to 7.5 parts by mass, still more preferably 2 to 5 parts by mass.

[water] The skin external composition of the present invention may contain water in addition to the above-mentioned (A) component and (B) component, as long as the effect of the present invention is not hindered. Although not limited, the content of water is preferably 0.1% by mass to 30% by mass, more preferably 1% by mass to 20% by mass, and still more preferably 2% by mass to 15% by mass relative to the total amount of the composition for external use on skin. quality%. It may be 0.1 to 90 mass %, 0.5 to 80 mass %, 1 to 70 mass %, 2 to 60 mass %, or the like.

[Vitamin E] The skin external composition of the present invention may contain vitamin E such as tocopherol, tocopherol salts, and tocopherol derivatives, in addition to the above-mentioned (A) components and (B) components, as long as the effect of the present invention is not hindered. The tocopherol, tocopherol salt, and tocopherol derivatives used in the present invention can be used in the fields of pharmaceuticals, quasi-drugs, or cosmetics and are commonly used as components of external preparations for skin. (d body), levorotatory body (l body), or any of the dl body, and can be any of the structures of α, β, γ, and δ. Examples of tocopherols include d-α-tocopherol, d-β-tocopherol, d-γ-tocopherol, d-δ-tocopherol, l-α-tocopherol, l-β-tocopherol, l-gamma-tocopherol, l-delta-tocopherol, dl-alpha-tocopherol, dl-beta-tocopherol, dl-gamma-tocopherol, dl-delta-tocopherol and the like as mixtures of these. Although the derivative of tocopherol is not limited, it is preferably an ester of tocopherol. Examples of derivatives of tocopherol include tocopheryl acetate, tocopherol nicotinate or its salt, tocopheryl succinate or its salt, tocopherol linolenic acid ester, tocopherol phosphate or its salt , (linoleic acid/oleic acid) tocopherol, and one of the group consisting of tocotrienol, etc.

In the skin external composition of the present invention, the total content of vitamin E relative to the total amount of the skin external composition is not particularly limited, but is preferably 0.00001 to 10 mass %, more preferably 0.0001 to 5 mass %. The mass % is more preferably 0.001 to 1 mass %, and still more preferably 0.01 to 0.5 mass %.

[surfactant] The skin external composition of the present invention may contain a surfactant in addition to the above-mentioned (A) component and (B) component, as long as the effect of the present invention is not hindered. In the case of containing a surfactant, although not limited, it is preferably a nonionic surfactant, for example, polyoxyethylene hydrogenated castor oil 40, polyoxyethylene hydrogenated castor oil 60, polyoxyethylene hydrogenated castor oil can be used 80. Polyoxyethylene polyoxypropylene decyl tetradecyl ether, polyoxyethylene (20) polyoxypropylene (4) cetyl ether, PEG-8 glyceryl isostearate, polyoxyethylene sorbitan monohydrate Laurate (20E.O.), Polyoxyethylene Sorbitan Isostearate (20E.O.), Polyoxyethylene Sorbitan Stearate (20E.O.), Coconut Oil Fatty Acids Polyglycerol-10 Ester, Coconut Oil Fatty Acid Polyglycerol-3 Ester, Coconut Oil Fatty Acid PEG-7 Glycerol Ester, Dioleic Acid Polyglyceryl-10 Ester, Diisostearate Polyglyceryl-10 Ester, Triisostearic Acid PEG -40 glyceride, PEG-40 glycerol isostearate, polyglycerol-10 trilaurate, hexaglycerol tricaprylate, polyglyceryl laurate, polyglyceryl myristate, polyoxyethylene lauryl ether, etc. , especially preferably polyoxyethylene polyoxypropylene decyl tetradecyl ether, polyoxyethylene hydrogenated castor oil 40, polyoxyethylene hydrogenated castor oil 60, polyoxyethylene hydrogenated castor oil 80, polyoxyethylene sorbitan Isostearate (20E.O.), polyoxyethylene sorbitan monolaurate (20E.O.), polyglyceryl laurate.

In the skin external composition of the present invention, the total content of the surfactant relative to the total amount of the skin external composition is appropriately set according to the balance with other components. The total content of the surfactant is preferably 0.001 to 10% by mass, more preferably 0.005 to 7% by mass, and still more preferably 0.01 to 5% by mass relative to the total amount of the composition for external use on skin.

[other ingredients] In the skin external composition of the present invention, in addition to the above-mentioned (A) components and (B) components, one or more of the following components may be prepared in combination: a whitening component, an anti-inflammatory component, an antibacterial component, a cell activation component, Various ingredients such as astringent ingredients, antioxidant ingredients, acne-relieving ingredients, anti-aging ingredients, collagen and other active ingredients synthesis promoting ingredients, blood circulation promoting ingredients, moisturizing ingredients, and anti-aging ingredients. Preferably, it is one or more of a whitening ingredient, an anti-inflammatory ingredient, an antibacterial ingredient, a cell activating ingredient, an astringent ingredient, an antioxidant ingredient, an anti-aging ingredient, or a moisturizing ingredient. Particularly preferred combinations of these ingredients include: a combination with a whitening ingredient, a combination with a whitening ingredient and an antioxidant ingredient, each combination with an antioxidant ingredient, a combination with an anti-aging ingredient, and a combination with a whitening ingredient and an anti-aging ingredient each combination. These components are not particularly limited as long as they are intended to be used as external preparations for skin in the fields of pharmaceuticals, quasi-drugs, or cosmetics, and any of these components can be appropriately selected and used. Among these components, for example, dipotassium glycyrrhizinate can be preferably used as an anti-inflammatory component. These components may be used in one type or in combination of two or more types.

In addition to the above-mentioned components, the composition for external use on the skin of the present invention may further contain solubilizing components, oils and fats, saccharides, or transdermal absorption promoting components. In particular, the stability, effectiveness, and feeling of use of ascorbic acid in the aqueous solvent can be further improved by preparing solubilizing components or oils and fats.

The composition for external use on the skin of the present invention can be prepared as needed as pharmaceuticals, quasi-drugs or within the range of quantity and quality that do not impair the appearance stability or viscosity, and also within the range of quantity and quality that does not impair the efficacy of the present invention. Various components commonly used as components of external preparations in the cosmetic field, such as amino acids, irritation reducing agents, thickening agents, preservatives, UV protection agents, colorants, dispersants, additional pH adjusters, fragrances, etc. These components may be used in one type or in combination of two or more types.

[container] The skin external composition of the present invention is collected in a container containing a polyolefin-containing resin partially or entirely on the surface contacting the skin external composition. Here, as the polyolefin, polyethylene (PE; polyethylene) (including high density polyethylene (HDPE; High Molecular Weight Polyethylene), low density polyethylene (LDPE; Low Density Polyethylene), ultra-low density polyethylene, Linear low density polyethylene (LLDPE; Linear Low Density Polyethylene), ultra-high molecular weight polyethylene, etc.), polypropylene (PP; polypropylene) (including homopolymers, random copolymers, block copolymers, etc.), and Ethylene/propylene copolymer, cyclic olefin copolymer, polymethylpentene, polybutene-1, 1,2-polybutadiene, more preferably polyethylene resin or polypropylene resin. Among them, resins containing at least polyethylene are particularly preferred.

The shape of the container to be used can be appropriately selected according to the purpose, and examples thereof include a tube type, a can type, a dropper type, a dispenser type, a bag pack, a spray type, a bottle type, and a carrying case. Among them, containers that have undergone a heat-sealing step are preferred, and tubes, bags, and carrying bags are particularly preferred.

Specific specific examples of the container include, for example, an aluminum tube in which a resin containing polyolefin is laminated on the innermost surface to which the skin external composition contacts, and an aluminum tube containing a polyolefin-containing resin on the innermost surface in contact with the skin external composition. Storage containers such as aluminum bags laminated with olefin resins, self-supporting pouches with clips laminated with polyolefin-containing resin on the innermost surface in contact with the skin external composition, and use the innermost surface in contact with the skin external composition Containers, etc., whose lids are heat-sealed, such as aluminum films laminated with polyolefin-containing resins.

When the composition for external use on the skin of the present invention is in the form of being collected in a tube, for example, effects such as being easy to drop from one drop to several drops can be expected. Therefore, although not limited, it is preferable that a part or all of the dripping part is comprised with polyolefin resin.

[form] The composition for external use on the skin of the present invention can be prepared and mixed with any one or a plurality of the above-mentioned optional components other than the components (A) and (B) and, if necessary, the component (C), and further, other components can be prepared as needed. It is prepared into liquid, emulsion, cream, paste, mousse, gel, sheet (supported by substrate), aerosol, spray shape and other desired forms. Although not limited, it is preferable to make it into a liquid form from the viewpoint of remarkably exhibiting the effect of this invention. These forms can be produced by a common method in the industry.

[viscosity] The composition for external use on skin of the present invention can be prepared as a composition having a desired moderate viscosity when used as a composition for external use on skin especially applied to the skin. The viscosity of the composition for external use on the skin of the present invention is not particularly limited. For example, in the case of measuring with an E-type viscometer at 25° C., the viscosity is usually about 1 mPa·s to 300 mPa·s, preferably 1 mPa·s to 200 mPa·s about 1 mPa·s to 100 mPa·s, more preferably about 1 mPa·s to 50 mPa·s. More specifically, the viscosity measurement method is based on the Japanese Pharmacopoeia 16th Revised Edition [B] General Test Method 2. Physical Test Method Other Physical Test Methods 2.53 Viscosity Measurement Method 2. Second Method Rotational Viscometer Method 2.1.3 Cone-Flat Plate The method described in the rotary viscometer (cone and plate viscometer).

[pH] The skin external composition of the present invention generally only needs to have a liquid property of pH 1 to pH 8, but from the viewpoints of stability of ascorbic acid, low irritation to skin or mucous membranes, and good skin feel, pH 2 to pH 8 is preferred. pH 7, more preferably pH 2 to pH 6, still more preferably pH 2 to pH 5.0, most preferably pH 2 to pH 4.5. An acidic region is more desirable.

[use] The skin external composition of the present invention is particularly effective as a whitening agent, an anti-inflammatory agent, and an anti-aging agent, for example, it has the effects of preventing or treating acne and anti-oxidation. Furthermore, depending on the application to the skin, it may have the effect of improving the transparency of the skin, maintaining moisture, adjusting the texture of the skin, and suppressing roughness. Furthermore, it is sometimes used for moisturizing the skin concerned with acne scars or pores, making pores less noticeable, smoothing the skin, and moisturizing the skin. In addition, it can also be used for the prevention or treatment of blemishes.

The skin external composition of the present invention can be made into, for example, basic cosmetics such as cosmetic lotion, lotion, sunscreen, lotion, cream, lotion, oil and facial mask; foundation, lipstick, lip balm, mascara, eye shadow, eyeliner, eyebrow Make-up cosmetics such as pens and nail agents; cleaning agents such as facial cleanser or makeup remover, body wash; Various skin compositions for external use in the field of cosmetics, external medicines or external quasi-drugs, such as acne treatment agents, hemorrhoid agents, bactericidal disinfectants, whitening agents, and ultraviolet protection agents. In terms of the effect on the skin, the present invention is preferably a product applied to the skin, such as an external preparation for the skin (a preparation for the skin). The composition of the present invention can be used once to several times a day in a known or conventional usage and dosage, depending on the application and the like.

[Method for improving wettability] The present invention also includes the following method of imparting a wettability-improving effect: by causing (A) at least one selected from the group consisting of ascorbic acid and a salt of ascorbic acid; and (B) a lower alcohol to coexist, the composition The substance imparts a wettability-enhancing effect to a resin containing polyolefin or a container formed from such resin. In the method for improving wettability of the present invention, the composition for external skin use of (A) ascorbic acid and ascorbic acid salts is set to contain (A) at least one selected from the group consisting of ascorbic acid and ascorbic acid; and (B) a lower alcohol composition for external use or any of these components The content, etc., other ingredients and their contents are based on the contents described in the aforementioned composition for external use on skin.

[pH fluctuation suppression method] The present invention also includes the following method of inhibiting pH change: by causing (A) at least one selected from the group consisting of ascorbic acid and a salt of ascorbic acid; and (B) a lower alcohol to coexist, the composition is In the case of being collected and stored in a resin containing polyolefin or a container molded of such resin, pH fluctuation is suppressed. Since pH fluctuations are related to the quality fluctuations of the composition, suppression of fluctuations involves quality maintenance. In this method of the present invention, regarding setting as containing (A) at least one selected from the group consisting of ascorbic acid and ascorbic acid salts; and (B) a lower alcohol composition for external use on skin or the content of these components, etc., Other ingredients and their contents are based on the contents described in the aforementioned composition for external use on skin.

[Method for promoting defoaming] The present invention also includes the following method of promoting defoaming: by making (A) at least one selected from the group consisting of ascorbic acid and a salt of ascorbic acid; and (B) coexisting with a lower alcohol, the composition is Promotes defoaming when collected in polyolefin-containing resins or containers molded from such resins. The compounding components (in particular, ascorbic acid, etc.) may be colored due to exposure to air, which affects stability. In particular, in a liquid composition, when the disappearance rate (defoaming rate) of the bubbles generated by vibration or shock is slow, the chance of contact between the ingredients and the air may be increased or prolonged. Therefore, promotion of defoaming involves quality maintenance of the composition. In this method of the present invention, regarding setting as containing (A) at least one selected from the group consisting of ascorbic acid and ascorbic acid salts; and (B) a lower alcohol composition for external use on skin or the content of these components, etc., Other ingredients and their contents are based on the contents described in the aforementioned composition for external use on skin. [Example]

Next, although an Example demonstrates this invention concretely, this invention is not limited to the following Example. In addition, the unit of each component amount in a table|surface is mass %, unless otherwise specified in a table|surface.

The skin external compositions having the compositions shown in Tables 1 to 13 were prepared according to conventional methods.

[Test Example 1: Wettability Test] Regarding the compositions of Examples and Comparative Examples, the wettability of polyethylene resin (manufactured by AS ONE: PEN-050503) and polypropylene resin (manufactured by AS ONE: PPN-050503) was evaluated by contact angle measurement . The resins each having a thickness of 3 mm were cut into 2 cm x 6 cm and used. Using the syringe attached to the contact angle meter, 0.5 μL of the test solution was dropped on the surface of the disk, and the contact angle was measured. Each composition was measured continuously 10 times under the same temperature condition (room temperature) using the same container material, and the average value thereof was evaluated. The results are shown in the table. The measurement conditions of the contact angle are as follows. Machine used: Contact Angle Meter Drop Master 500 (Concord Interface Science) Droplet volume: 0.5 μL Contact angle calculation method: θ/2 method Material of contact surface: polyethylene resin, polypropylene resin The meanings of the abbreviations in the table are as follows. VB6: Pyridoxine hydrochloride VC ethyl: 3-O-ethyl ascorbic acid VC glucoside: L-ascorbic acid 2-glucoside IPMP: isopropyl methylphenol PG: 1,2-Propanediol PD: 1,3-Propanediol BG: Butanediol

[Table 1] Evaluation on polyethylene resin Comparative Example 1 Reference Example 1 Example 1-1 Example 1-2 Examples 1-3 Examples 1-4 Examples 1-5 Examples 1-6 Examples 1-7 Examples 1-8 Examples 1-9 A) Ascorbic acid - - 5 5 1 5 1 5 1 5 1 B) Ethanol - 3 3 3 3 3 3 3 3 3 3 C1)B6 - - - 0.1 0.1 - - - - - - C2) Salicylic acid - - - - - 0.1 0.1 - - - - C4) VC glucoside - - - - - - - 2 2 - - C4) VC ethyl - - - - - - - - - 2 2 PG 10 10 10 10 10 10 10 10 10 10 10 water residual residual residual residual residual residual residual residual residual residual residual total 100 100 100 100 100 100 100 100 100 100 100 Contact angle (difference from Comparative Example 1) 0 4.2 -1.8 -5.7 -2 -15.1 -10.4 -5.2 -4.3 -5.8 -5.1

[Table 2] Evaluation on polyethylene resin Comparative Example 2 Reference example 2 Example 2-1 Example 2-2 Example 2-3 A) Ascorbic acid - - 5 5 1 B) Ethanol - 5 5 5 5 C3) IPMP - - - 0.1 0.1 PD 20 20 twenty one 20 20 water residual residual residual residual residual total 100 100 100 100 100 Contact angle (difference from Comparative Example 2) 0 2.1 -0.2 -6.5 -6.4

Compared with the composition of the comparative example, although the contact angle was increased due to the addition of ethanol, the contact angle of the composition of the example with respect to the polyethylene resin was decreased, and it was found that the wettability was improved. [Table 3] Evaluation on polypropylene resin Comparative Example 3 Reference Example 3 Example 3-1 Example 3-2 Example 3-3 Example 3-4 Example 3-5 Examples 3-6 Examples 3-7 Examples 3-8 Examples 3-9 Examples 3-10 Example 3-11 A) Ascorbic acid - - 5 5 1 3 5 1 3 5 1 5 1 B) Ethanol - 3 3 3 3 3 3 3 3 3 3 3 3 C1)B6 - - - 0.1 0.1 0.1 - - - - - - - C2) Salicylic acid - - - - - - 0.1 0.1 0.1 - - - - C4) VC glucoside - - - - - - - - - 2 2 - - C4) VC ethyl - - - - - - - - - - - 2 2 PG 10 10 10 10 10 10 10 10 10 10 10 10 10 water residual residual residual residual residual residual residual residual residual residual residual residual residual total 100 100 100 100 100 100 100 100 100 100 100 100 100 Contact angle (difference from Comparative Example 3) 0 -10.7 -12.1 -11.7 -13.4 -12.9 -11.9 -13.4 -12.9 -13 -14.2 -12.3 -14.1

[Table 4] Evaluation on polypropylene resin Comparative Example 4 Reference Example 4 Example 4-1 Example 4-2 Example 4-3 A) Ascorbic acid - - 5 5 1 B) Ethanol - 5 5 5 5 C3) IPMP - - - 0.1 0.1 PD 20 20 20 20 20 water residual residual residual residual residual total 100 100 100 100 100 Contact angle (difference from Comparative Example 4) 0 -2.6 -7.8 -15 -18

Compared with the composition of the comparative example, the composition of the example has a smaller contact angle with respect to the polypropylene resin, and it can be seen that the wettability is improved.

In the embodiment with pyridoxine, salicylic acid, isopropyl methylphenol, 3-O-ethyl ascorbic acid or L-ascorbic acid 2-glucoside, the contact angle is smaller, and the wettability is improved .

In addition, in the test example in which 1, 3- propanediol was changed into butanediol or glycerol similarly, the improvement of wettability was observed. [Table 5] Evaluation when PD was changed to glycerol Comparative Example 5 Example 5-1 Example 5-2 Example 5-3 Example 5-4 Example 5-5 Embodiment 5-6 Examples 5-7 A ascorbic acid - - 5 5 5 5 5 5 B Ethanol - 5 5 5 5 5 5 5 C1 Pyridoxine hydrochloride - - - 0.1 - - - - C2 Salicylic acid - - - - 0.1 - - - C3 IPMP - - - - - 0.1 - - C4 Ascorbyl Glucoside - - - - - - 2 - C5 Ethyl ascorbic acid - - - - - - - 2 glycerin 20 20 20 20 20 20 20 20 water residual residual residual residual residual residual residual residual total 100 100 100 100 100 100 100 100 PE Contact angle (difference from Comparative Example 5) 2.7 -2.7 -8.5 -10.6 -9.3 -8.3 -8 PP 3.2 -1.4 -2.4 -6.3 -12.3 -4.5 -4.8 [Table 6] Evaluation when PD was changed to BG Comparative Example 6 Example 6-1 Example 6-2 Example 6-3 Example 6-4 Example 6-5 Example 6-6 Example 6-7 A ascorbic acid - 5 5 5 5 5 5 B Ethanol - 5 5 5 5 5 5 5 C1 Pyridoxine hydrochloride - - - 0.1 - - - - C2 Salicylic acid - - - - 0.1 - - - C3 IPMP - - - - - 0.1 - - C4 Ascorbyl Glucoside - - - - - - 2 - C5 Ethyl ascorbic acid - - - - - - - 2 BG 20 20 20 20 20 20 20 20 water residual residual residual residual residual residual residual residual total 100 100 100 100 100 100 100 100 PE Contact angle (difference from Comparative Example 6) 0.3 -10.4 -12.3 -14.3 -18.7 -13.4 -15.7 PP -0.9 -8 -13.3 -13.5 -20.6 -13.7 -14.4

[Test Example 2] In a polyethylene container (AS ONE PE centrifuge tube (spitz) 10mL (type 2-467-02), 9mL of the composition (ethanol and polyol (1, 2) as shown in the comparative example in the table were prepared. -Propanediol, 1,3-propanediol or glycerin)), used for aging. Specifically, it was left to stand at 60°C for 7 days with the lid upright. Similarly, as shown in the table, for the prepared The compositions shown in the examples in which the components (C-1), (C-2), (C-3), or (C-4) were formulated with ethanol, polyol, and ascorbic acid were similarly used for aging Then, the pH before and after aging was measured, and the change was evaluated.

[Table 7] Comparative Example 7 Example 7-1 Example 7-2 Example 7-3 Example 7-4 Example 7-5 Example 7-6 Example 7-7 A ascorbic acid - 5 5 5 5 5 5 5 B Ethanol 5 5 5 5 5 5 5 5 C1 Pyridoxine hydrochloride - - 0.05 - - - - - C2 Salicylic acid - - - 0.05 - - - - C3 IPMP - - - - 0.05 0.1 - - C4 Ethyl ascorbic acid - - - - - - 0.5 2 PD 20 20 20 20 20 20 20 20 water residual residual residual residual residual residual residual residual total 100 100 100 100 100 100 100 100 pH Change improvement rate (%) 90.0 99.5 91.0 99.0 94.5 95.0 90.5 [Table 8] Comparative Example 8 Example 8-1 Example 8-2 Example 8-3 Comparative Example 9 Example 9-1 Example 9-2 A ascorbic acid - 5 5 5 - 5 5 B Ethanol 5 5 5 5 5 5 5 C1 Pyridoxine hydrochloride - - 0.1 - - - 0.1 C2 Salicylic acid - - - 0.1 - - - C3 IPMP - - - - - - - PD - - - - - - - BG 20 20 20 20 - - - glycerin - - - - 20 20 20 water residual residual residual residual residual residual residual total 100 100 100 100 100 100 100 pH Change improvement rate (%) 96.1 99.0 96.5 89.7 98.9

As a result, in the composition corresponding to the comparative example in which ethanol and polyol (1,2-propanediol, 1,3-propanediol, or glycerol) were prepared, the pH changed due to aging, but when ascorbic acid, (C -1), (C-2), (C-3) or the composition of the example of the (C-4) component, it becomes difficult to change. Here, the pH change improvement rate (%) was obtained as follows. pH change improvement rate (%)=(|difference before and after aging corresponding to the comparative example|-|difference before and after aging of each example|)/|difference before and after aging corresponding to the comparative example|×100

Next, in a polypropylene container (AS ONE PP spitz centrifuge tube 10 mL (type 4-812-01)), ethanol and polyol (1,2-propanediol, 1,2-propanediol, 1,2-propanediol, 3-propanediol or glycerin) was used for aging in the same manner as in the test using a polyethylene container. Similarly, the compositions shown in the examples in which ethanol, polyol, and ascorbic acid were prepared, and then (C-1), (C-2), (C-3), or (C-4) were prepared for aging.

[Table 9] Comparative Example 10 Example 10-1 Example 10-2 Example 10-3 Example 10-4 Example 10-5 Example 10-6 Example 10-7 Example 10-8 Example 10-9 Examples 10-10 Examples 10-11 A ascorbic acid - 5 5 5 5 5 5 5 5 5 5 5 B Ethanol 5 5 5 5 5 5 5 5 5 5 5 5 C1 Pyridoxine hydrochloride - - 0.1 - - - - 0.05 - - - - C2 Salicylic acid - - - 0.1 - - - - 0.05 - - - C3 IPMP - - - - 0.1 - - - - 0.05 - - C4 Ascorbyl Glucoside - - - - - 2 - - - - 0.5 - C4 Ethyl ascorbic acid - - - - - - 2 - - - - 0.5 PD 20 20 20 20 20 20 20 20 20 20 20 20 water residual residual residual residual residual residual residual residual residual residual residual residual total 100 100 100 100 100 100 100 100 100 100 100 100 pH Change improvement rate (%) 26.5 82.1 98.3 96.6 29.9 70.9 85.5 76.1 93.2 64.1 94.9 [Table 10] Comparative Example 11 Example 11-1 Example 11-2 Example 11-3 Example 11-4 Example 11-5 Comparative Example 12 Example 12-1 Example 12-2 A ascorbic acid - 5 5 5 5 5 - 5 5 B Ethanol 5 5 5 5 5 5 5 5 5 C1 Pyridoxine hydrochloride - - 0.1 - - - - - - C2 Salicylic acid - - - 0.1 - - - - - C3 IPMP - - - - 0.1 - - - - C4 Ethyl ascorbic acid - - - - - 2 - - 2 BG 20 20 20 20 20 20 - - - glycerin - - - - - - 20 20 20 water residual residual residual residual residual residual residual residual residual total 100 100 100 100 100 100 100 100 100 pH Change improvement rate (%) 96.2 98.8 97.9 99.3 99.7 81.5 97.5

As a result, in the composition corresponding to the comparative example in which ethanol and polyol (1,2-propanediol, 1,3-propanediol, or glycerol) were prepared, the pH fluctuated due to aging, but ascorbic acid, ( C-1), (C-2), (C-3) or the composition of the example of the component (C-4), it becomes difficult to change.

Furthermore, even the addition of ascorbic acid to the glass container did not produce this effect. [Table 11] Reference Example 5 Reference Example 6 A ascorbic acid - 5 B Ethanol 5 5 C1 Pyridoxine hydrochloride - - PD 20 20 water residual residual total 100 100 pH Change improvement rate (%) -47.6

[Test Example 3] Add 5 mL of the prepared composition to a polyethylene container (AS ONE PE spitz centrifuge tube 10 mL (model 2-467-02), and use a shaker (Iwaki KM Shaker (MODEL: VD-X) with the lid of the container facing down. )) 350 times (350 spm, 1 minute), and the absorbance (wavelength 660 nm) after 3 minutes was measured with a spectrophotometer (AS ONE ASV11d-H).

[Table 12] Comparative Example 13 Example 13-1 Example 13-2 Example 13-3 Example 13-4 Example 13-5 Example 13-6 Example 13-7 Example 13-8 Example 13-9 A ascorbic acid - 5 5 5 5 5 5 5 5 5 B Ethanol 5 5 5 5 5 5 5 5 5 5 C1 Pyridoxine hydrochloride - - 0.05 0.1 - - - - - - C2 Salicylic acid - - - - 0.05 - - - - - C3 IPMP - - - - - 0.05 0.1 - - - C4 Ascorbyl Glucoside - - - - - - - 0.5 2 - C4 Ethyl ascorbic acid - - - - - - - - 2 PD 20 20 20 20 20 20 20 20 20 20 water residual residual residual residual residual residual residual residual residual residual total 100 100 100 100 100 100 100 100 100 100 Improvement rate after 180 seconds (%) 15.9 33.3 26.1 30.4 49.3 66.7 31.9 30.4 46.4 [Table 13] Comparative Example 14 Example 14-1 Example 14-2 Example 14-3 Comparative Example 15 Example 15-1 Example 15-2 A ascorbic acid - 5 5 5 - 5 5 B Ethanol 5 5 5 5 5 5 5 C3 IPMP - - 0.1 - - - 0.1 C4 Ascorbyl Glucoside - - - 2 - - - BG 20 20 20 20 - - - glycerin - - - - 20 20 20 water residual residual residual residual residual residual residual total 100 100 100 100 100 100 100 Improvement rate after 180 seconds (%) 11.1 27.8 22.2 36.7 61.1

Compared with the absorbance of the composition containing polyol and ethanol, the absorbance of the composition containing ascorbic acid or other (C) components is lower, and the bubbles that are generated briefly disappear easily. Furthermore, no change in absorbance was observed in the glass. Here, the improvement rate was calculated|required as follows. Improvement rate=(absorbance after 180 seconds corresponding to the comparative example-absorbance after 180 seconds of each example)/absorbance after 180 seconds corresponding to the comparative example)×100

[prescription example] Table 14 below shows a prescription example. The prescription examples are all cosmetic liquids, and each prescription is filled in a container made of polyethylene resin or polypropylene resin. The contents in the formulation examples are all mass %.

[Table 14] Element Prescription Example 1 Prescription Example 2 Prescription Example 3 Prescription Example 4 Prescription Example 5 Prescription Example 6 Prescription Example 7 Prescription Example 8 Prescription Example 9 Prescription Example 10 Prescription Example 11 Prescription Example 12 Prescription Example 13 Prescription Example 14 ascorbic acid 0.5 1 1 3 3 3 5 5 5 5 10 15 20 30 Ethanol 4 2 5 1 3 6 2 4 6 1 5 7 4 4 Pyridoxine hydrochloride 0.01 0.05 - 0.1 0.05 - - 0.1 0.1 - - - 0.01 - Salicylic acid - - - - 0.2 0.1 0.1 0.05 - - 0.05 0.2 - - isopropyl methylphenol - - - 0.05 - 0.1 0.05 - 0.1 0.1 0.05 - 0.01 Ascorbic acid 2-glucoside 2 - - 0.01 - - 0.001 - 2 0.001 0.05 0.05 - - 3-O-ethylascorbic acid - 1 - - 0.05 - - 0.05 - 0.001 - 0.1 - - Tetrakis(2-hexyldecanoic acid)ascorbic acid - - 2 - - 0.05 - 0.05 0.05 0.001 - 0.05 0.05 - Tocopheryl acetate 0.05 - - 0.05 - 0.05 - - 0.05 - - - - - d-delta-tocopherol - 0.1 - - 0.05 - 0.05 - 0.1 - 0.1 0.1 - 0.1 Dipotassium Glycyrrhizinate 0.05 0.05 - 0.05 - - 0.1 - - 0.1 - - - - D-Panthenol - - - - 0.1 - 0.1 0.05 - 0.1 - - - - Allantoin 0.05 - - - 0.05 - - - 0.05 - - - - - Gluconate 0.01 0.01 - - 0.001 - 0.001 0.1 - 0.15 0.05 0.05 - - Lactic acid 0.01 0.01 - 0.001 0.001 0.1 - 0.15 - 0.1 - 0.05 1,2-Propanediol 10 10 5 5 1 1 10 10 5 5 10 10 10 10 1,3-Propanediol 5 5 10 10 20 20 5 10 20 10 20 25 30 20 1,3-Butanediol 10 - 10 20 15 20 15 - 20 20 20 15 15 10 Dipropylene glycol - 30 25 - 25 20 20 20 25 15 10 - - polyethylene glycol 400 3 5 - 10 10 3 - 5 10 5 - - - Isopentyl glycol 20 - 15 20 15 - 10 10 10 - 15 - - - Concentrated glycerin - 10 - 10 - 15 - - - 15 3 10 - 10 Polyoxyethylene polyoxypropylene decyl tetradecyl ether 0.1 - - 0.15 - - 0.2 - - 0.5 - - 1 - Polyoxyethylene hydrogenated castor oil - 0.1 - - 0.15 - - 0.2 - - 0.5 - - 1 polyoxyethylene cetyl ether - - 0.1 - - 0.15 - - 0.2 - - 0.5 - - purified water residual residual residual residual residual residual residual residual residual residual residual residual residual residual total 100 100 100 100 100 100 100 100 100 100 100 100 100 100

Claims (7)

A composition for external use on skin, comprising (A) at least one selected from the group consisting of ascorbic acid and salts of ascorbic acid; and (B) a lower alcohol; A part or all of the surface collected on the surface in contact with the aforementioned composition for external use on skin is formed in a container containing a polyolefin-containing resin. The composition for external use on skin according to claim 1, wherein the total content of the component (B) is 1 to 7% by mass. The composition for external use on skin according to claim 1, further comprising a compound selected from the group consisting of the following (C-1), (C-2), (C-3), and (C-4) At least one of: (C-1) Pyridoxine and/or a pyridoxine salt; (C-2) at least one selected from the group consisting of salicylic acid, derivatives of salicylic acid, and salts of the aforementioned salicylic acid and the aforementioned derivatives of salicylic acid; (C-3) isopropyl methylphenol; (C-4) Ascorbic acid derivatives. The composition for external use on skin according to claim 1, wherein the component (B) contains at least ethanol. The skin external composition according to claim 1, wherein the total content of the component (A) is 0.5% by mass to 30% by mass. The skin external composition according to claim 1, wherein the container is a tube type, a bag package, or a carrying case. A method for imparting a wettability-improving effect, by causing (A) at least one selected from the group consisting of ascorbic acid and salts of ascorbic acid to coexist with (B) a lower alcohol in the composition, and the above-mentioned composition Provides a wettability-improving effect to resins containing polyolefins.