TW202214130A - Compositions and methods - Google Patents

Abstract

The present invention provides an amorphous solid for use in aerosol generation, the amorphous solid comprising: about 1 to about 12 wt% constituent, derivative or extract of cannabis; about 10 to about 80 wt% aerosol-former material; gelling agent; and optionally filler, wherein the amount of gelling agent and optional filler taken together is from about 10 to about 60 wt%; wherein the wt% values are calculated on a dry weight basis.

Description

Composition and method

Field of Invention

The present invention relates to an aerosol-generating means for delivering a component, derivative or extract of cannabis. The present invention also relates to a composition for the oral delivery of a component, derivative or extract of cannabis.

Background of the Invention

Smoking articles such as cigarettes, cigars and similar smoking products burn tobacco during use to produce tobacco smoke. Substitutes for this type of article release the compound from the matrix material by heating rather than burning it, releasing an inhalable aerosol or vapor. These may be referred to as non-combustible smoking articles, aerosol-generating assemblies or non-combustible aerosol supply systems.

An example of such a product is a heating device that releases a compound by heating, rather than burning, a solid aerosolizable material. In certain instances, such solid aerosolizable material may comprise tobacco material. Heating volatilizes at least one component of the material, usually forming a respirable aerosol. These products may be referred to as heat-not-burn devices, tobacco heating devices or tobacco heating products (THP). A variety of different devices are currently known for volatilizing at least one component of a solid aerosolizable material.

As another example, there are currently electronic cigarette/tobacco heating product mixing devices, also known as electronic cigarette mixing devices. These mixing devices contain a liquid source (which may or may not contain nicotine), which is vaporized by heating to produce an inhalable vapor or aerosol. The device additionally comprises a solid aerosolizable material, which may or may not contain tobacco material, and whose constituents are contained in the inhalable vapor or aerosol, to produce the inhalation medium.

Summary of Invention

In a first aspect, an amorphous solid for generating an aerosol is provided, the amorphous solid comprising: From about 1 to about 12 wt% cannabis constituents, derivatives or extracts; from about 10 to about 80 wt % of the aerosol former material; gelling agent; and optional filler, wherein the total amount of the gelling agent and optional filler is from about 10 to about 60 wt%; The wt% value is calculated on the basis of dry weight.

In a second aspect, an aerosol-generating material is provided comprising the amorphous solid of the first aspect.

In a third aspect, a consumable for use in a non-flammable aerosol supply device is provided, the consumable comprising the aerosol-generating material of the second aspect.

In a fourth aspect, a non-flammable aerosol supply system is provided, which includes the consumable of the third aspect and a non-flammable aerosol supply device.

In a fifth aspect, a composition for oral delivery of a component, derivative or extract of cannabis is provided, the composition comprising an amorphous solid comprising: From about 1 to about 12 wt% cannabis constituents, derivatives or extracts; from about 10 to about 80 wt% of a humectant; gelling agent; and optional filler, wherein the total amount of the gelling agent and optional filler is from about 10 to about 60 wt%; The wt% value is calculated on the basis of dry weight.

In a sixth aspect, there is provided a method of forming an amorphous solid as described in the first aspect or as defined in the fifth aspect, the method comprising: (a) providing a slurry comprising the cannabis ingredient, derivative or extract, the gelling agent, the aerosol former material or wetting agent, a solvent and any optional other ingredients of an amorphous solid; (b) forming the slurry layer; (c) curing the slurry layer; and (d) drying the slurry to form the amorphous solid.

In a seventh aspect, a slurry is provided, comprising: From about 1 to about 12 wt% cannabis constituents, derivatives or extracts; about 10 to about 80 wt% humectant; gelling agent; and optional filler, wherein the total amount of the gelling agent and optional filler is from about 10 to about 60 wt%; where the wt% value is calculated on a dry basis; and a solvent.

The aerosol former material used in the aerosol-generating amorphous solid is the same as the humectant used in the aerosol-generating amorphous solid for oral delivery of a component, derivative or extract of cannabis.

To the extent they are combinable, features related to one aspect of the invention are explicitly disclosed in combination with each of the other aspects.

Other aspects of the invention described herein may provide the use of the amorphous solid, aerosol-generating material, consumable, or non-combustible aerosol supply system for generating a respirable aerosol.

Further features and advantages of the present invention will become apparent from the following description (by way of example only) with reference to the accompanying drawings.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT

As described above, an amorphous solid for generating an aerosol is provided, the amorphous solid comprising: From about 1 to about 12 wt% cannabis constituents, derivatives or extracts; from about 10 to about 80 wt % of the aerosol former material; gelling agent; and optional filler, wherein the total amount of the gelling agent and optional filler is from about 10 to about 60 wt%; The wt% value is calculated on the basis of dry weight.

Also provided is a composition for oral delivery of a component, derivative or extract of cannabis, the composition comprising an amorphous solid comprising: From about 1 to about 12 wt% cannabis constituents, derivatives or extracts; from about 10 to about 80 wt% of a humectant; gelling agent; and optional fillers, wherein the total amount of gelling agent and optional filler is from about 10 to about 60 wt%; The wt% value is calculated on the basis of dry weight.

Amorphous solids may form part of the aerosol-generating material. Aerosol-generating materials are materials capable of generating aerosols, for example when heated, irradiated or energized in any other way.

Amorphous solids are alternatively referred to as "monolithic solids" (ie, non-fibrous). In some embodiments, the amorphous solid can be a dried gum. An amorphous solid is a solid material that retains some fluid, such as a liquid, in it. In some embodiments, the retained fluid may be water (eg, water absorbed from the surroundings of the amorphous solid) or the retained fluid may be a solvent (eg, when the amorphous solid is formed from a slurry). In some embodiments, the solvent can be water.

In some embodiments, the aerosol-generating material may comprise, for example, from about 50 wt%, 60 wt%, or 70 wt% amorphous solids, to about 90 wt%, 95 wt%, or 100 wt% amorphous solids Solid, based on the weight of the aerosol-generating material. These wt% values are based on a wet weight (WWB) basis, i.e. include any water or other solvents present in the aerosol-generating material or amorphous solid.

In some embodiments, the aerosol-generating material consists of the amorphous solid.

In some embodiments, the amorphous solid and/or aerosol-generating material consists essentially of or consists of: a gelling agent; a solvent; an aerosol former material; a component, derivative, or extract of cannabis; and Optional fragrances and/or optional additional actives and/or optional fillers.

In some cases, the amorphous solid and/or aerosol-generating material consists essentially of or consists of: a gelling agent; a solvent; an aerosol former material; and a component, derivative, or extract of cannabis.

In some embodiments, the amorphous solid and/or aerosol-generating material consists essentially of or consists of: gelling agent; solvent; aerosol-forming material; cannabinoid; and optional fragrance and/or Optional additional actives and/or optional fillers.

In some cases, the amorphous solid and/or aerosol-generating material consists essentially of or consists of: a gelling agent; a solvent; an aerosol former material; and a cannabinoid.

In some embodiments, the amorphous solid and/or aerosol-generating material consists essentially of or consists of: a gelling agent; water; an aerosol former material; a component, derivative, or extract of cannabis; and Optional fragrances and/or optional additional actives and/or optional fillers.

In some cases, the amorphous solid and/or aerosol-generating material consists essentially of or consists of: a gelling agent; water; an aerosol former material; and a component, derivative, or extract of cannabis.

In some embodiments, the amorphous solid and/or aerosol-generating material consists essentially of or consists of: a gelling agent; water; aerosol-forming material; cannabinoids; and optional fragrances and/or Optional additional actives and/or optional fillers.

In some cases, the amorphous solid and/or aerosol-generating material consists essentially of or consists of: a gelling agent; water; an aerosol former material; and a cannabinoid.

In some embodiments, the amorphous solid is a hydrogel and contains less than about 20 wt% water, calculated on a wet weight basis. In some cases, the hydrogel can contain less than about 15 wt%, 12 wt%, or 10 wt% water, calculated on a wet weight (WWB) basis. In some cases, the hydrogel can comprise at least about 1 wt%, 2 wt%, or at least about 5 wt% water (WWB).

In some embodiments, the amorphous solid may comprise less than about 20 wt%, eg, less than about 15 wt%, 12 wt%, or 10 wt% water, on a wet weight (WWB) basis. For example, the amorphous solid may contain about 1-15 wt% water, such as 3-12 wt% water (WWB). In some embodiments, the amorphous solid may contain about 1-5 wt% water (WWB). Cannabis constituents, derivatives or extracts

Suitably, the amorphous solid may comprise from about 1 to about 12 wt% of one or more constituents, derivatives or extracts of cannabis, for example from about 1.5 wt% or 2 wt% to about 10 wt%, 8 wt%, 7 wt% or 6 wt% cannabis constituents, derivatives or extracts (all calculated on a dry weight basis). For example, the amorphous solid may comprise about 1.5-10 wt%, about 1.5-8 wt%, about 2-8 wt%, or about 2-6 wt% of a cannabis component, derivative or extract.

As used herein, any compound or mixture of compounds obtainable from cannabis can be a component, derivative or extract thereof, including synthetic forms of such compounds or such compounds derived from other natural sources.

In some embodiments, a component, derivative or extract of cannabis comprises or is one or more compounds selected from the group consisting of cannabinoids, optionally phytocannabinoids, which may optionally be THC and/or CBD; terpenes, optionally triterpenes; alkaloids; and flavonoids.

In some embodiments, a component, derivative or extract of cannabis comprises one or more compounds selected from the group consisting of cannabinoids, optionally phytocannabinoids; or terpenes, optionally triterpenes.

In some embodiments, a component, derivative or extract of cannabis comprises one or more cannabinoids, optionally phytocannabinoids.

Cannabinoids are a class of natural or synthetic compounds that act on cannabinoid receptors in cells (i.e. CB1 and CB2), inhibiting the release of neurotransmitters in the brain. Cannabinoids can be naturally occurring (phytocannabinoids), derived from plants (such as marijuana), animals (endocannabinoids) or man-made (synthetic cannabinoids). Cannabis species express at least 85 different phytocannabinoids, divided into subclasses including cannabigerol, cannabichromene, cannabidiol, tetrahydrocannabinol, Cannabinol and cannabinodiol and other cannabinoids. Cannabinoids found in cannabis include, but are not limited to: cannabigerol (CBG), cannabichromene (CBC), cannabidiol (CBD), tetrahydrocannabinol (THC), cannabinol (CBN), cannabinodiol (CBDL), cannabicyclol (CBL), cannabivarin (CBV), tetrahydrocannabivarin ) (THCV), cannabidivarin (CBDV), cannabichromevarin (CBCV), cannabigerovarin (CBGV), cannabigerol monomethyl ether (CBGM), cannabinerolic acid, cannabidivarin (CBDA), cannabinol propyl variant (CBNV), cannabitriol (CBO), tetrahydrocannabinol acid ( tetrahydrocannabmolic acid) (THCA) and tetrahydrocannabivarinic acid (THCV A).

In some embodiments, the cannabinoid is a phytocannabinoid.

In some embodiments, the terpenes are triterpenes.

In certain embodiments, a component, derivative or extract of cannabis comprises or is tetrahydrocannabinol (THC) and/or cannabidiol (CBD).

In some embodiments, a component, derivative or extract of cannabis comprises or is THC.

In certain embodiments, a component, derivative or extract of cannabis comprises or is CBD.

The inventors have discovered that components, derivatives or extracts of cannabis (eg CBD) may have limited solubility in solutions for liquid nebulized delivery systems, which means that such systems may not be able to deliver high levels of such materials . The use of amorphous solids may allow for the addition of higher levels of cannabis components, derivatives or extracts, and thus may deliver greater amounts of cannabis components, derivatives or extracts to the user. Aerosol former material

The aerosol former material may contain one or more aerosol-forming ingredients.

Suitably, the amorphous solid may comprise from about 10 wt% to about 80 wt% aerosol former material (calculated on a dry basis), for example from about 20 wt%, 30 wt% or 40 wt% to about 80 wt% %, 75 wt%, 60 wt% or 50 wt%. In some embodiments, the amorphous solid may comprise about 20-80 wt% aerosol former material. In some embodiments, the amorphous solid may comprise about 50 to 80 wt%, eg, about 60 to 80 wt%, of the aerosol former material. In some embodiments, the amorphous solid may comprise about 30 to 40 wt % of the aerosol former material.

In some embodiments, the aerosol former material may comprise glycerol, propylene glycol, diethylene glycol, triethylene glycol, tetraethylene glycol, 1,3-butanediol, butane erythritol, meso-butane Tetraol, ethyl vanillate, ethyl laurate, diethyl suberate, triethyl citrate, triacetin, diacetin mixture, benzyl benzoate, benzyl phenylacetate, tributyl One or more of acid glycerides, lauryl acetate, lauric acid, myristic acid and propylene carbonate.

In some embodiments, the aerosol former material may include one or more of butane erythritol, propylene glycol, glycerol, and triacetin. In some cases, the aerosol former material comprises, consists essentially of, or consists of glycerol, or a mixture of glycerol and propylene glycol.

In some embodiments, the aerosol former material comprises a mixture of glycerol and propylene glycol in a weight ratio of glycerol to propylene glycol of about 3:1 to 1:3, about 2:1 to 1:2, about 1.5:1 to 1 :1.5, about 55:45 to 45:55, or about 45:55.

The aerosol former material can act as a plasticizer. If the level of plasticizer is too high, the amorphous solids may absorb water, preventing the material from creating a good consumer experience during use. If the plasticizer content is too low, the amorphous solid may become brittle and easily break. The plasticizer levels specified herein provide the flexibility of the amorphous solid, which allows winding of the amorphous solid or sheet of aerosol-generating material onto a spool, which can be used to manufacture aerosol-generating articles (consumables). gelling agent

Suitably, the amorphous solid comprises from about 10 wt% to about 60 wt% of a gelling agent, such as from about 10 wt%, 15 wt%, 20 wt% or 25 wt% to about 60 wt%, 50 wt%, 45 wt% wt%, 40 wt%, 35 wt% or 30 wt% of gelling agent (all calculated on a dry basis). For example, the amorphous solid may contain about 10-50 wt%, 15-45 wt%, 20-45 wt%, 15-40 wt%, or 20-30 wt% of the gelling agent.

In some embodiments, the amorphous solid may comprise about 15-35 wt% gelling agent.

In some embodiments, the gelling agent comprises a hydrocolloid.

In some embodiments, the gelling agent comprises (or is) selected from polysaccharide gelling agents, such as alginate, pectin, starch or derivatives thereof, cellulose or derivatives thereof, amylopectin, Carrageenan, agar and agarose; gelatin; gums such as xanthan, guar and acacia; silica or polysiloxanes such as PDMS and sodium silicate; clays such as kaolin; and polyethylene one or more compounds of alcohol.

In some embodiments, the gelling agent comprises (or is) one or more polysaccharide gelling agents.

In some embodiments, the polysaccharide gelling agent is selected from alginate, pectin, starch or derivatives thereof, or cellulose or derivatives thereof. In some embodiments, the polysaccharide gelling agent is selected from alginates and cellulose derivatives.

In some embodiments, the gelling agent is a polysaccharide gelling agent, optionally wherein the polysaccharide gelling agent is selected from alginates and cellulose derivatives.

In some embodiments, the alginate is sodium alginate.

In some embodiments, the polysaccharide gelling agent is a cellulose derivative. Without wishing to be bound by theory, the inventors believe that such gelling agents do not react with calcium ions to form crosslinks.

In some embodiments, the polysaccharide gelling agent is alginate.

In some embodiments, the gelling agent is not cross-linked. The absence of crosslinks in the gelling agent facilitates faster delivery of the cannabis ingredients, derivatives or extracts (and any optional additional actives and/or flavors) from the amorphous solid.

Examples of cellulose gelling agents (also referred to herein as cellulose derivatives) include, but are not limited to, hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, carboxymethylcellulose (CMC), hydroxypropylcellulose methyl cellulose (HPMC), methyl cellulose, ethyl cellulose, cellulose acetate (CA), cellulose acetate butyrate (CAB), and cellulose acetate propionate (CAP). In some embodiments, the cellulose or derivative thereof is selected from the group consisting of hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose (CMC), hydroxypropyl methyl cellulose (HPMC), methylcellulose, ethylcellulose, cellulose acetate (CA), cellulose acetate butyrate (CAB), and cellulose acetate propionate (CAP). In some embodiments, the cellulose derivative is CMC.

For example, in some embodiments, the gelling agent comprises (or is) alginate, pectin, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose, pullulan, xanthan gum, One or more of guar gum, carrageenan, agarose, gum arabic, calcined silica, PDMS, sodium silicate, kaolin, and polyvinyl alcohol.

In some embodiments, the gelling agent comprises (or is) one of hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose, guar gum, acacia, alginate and/or pectin or more.

In some cases, the gelling agent comprises (or is) alginate and/or pectin, and can be combined with a solidifying agent (eg, a calcium source) during the formation of the amorphous solid. In some cases, the amorphous solid may comprise calcium-crosslinked alginate and/or calcium-crosslinked pectin.

In some embodiments, the gelling agent comprises (or is) alginate, optionally wherein the alginate is present in the amorphous solid in an amount of about 15-40 wt% of the amorphous solid, such as about 15-25 wt% (based on dry weight).

In some embodiments, the alginate is the only gelling agent present in the amorphous solid.

In other embodiments, the gelling agent comprises alginate and at least one other gelling agent, such as pectin.

In particular embodiments, the gelling agent is carboxymethyl cellulose, optionally wherein the carboxymethyl cellulose (CMC) is present in an amount of about 15-50 wt %, such as about 20-40 wt % or about 30 wt%. In some embodiments, CMC is the only gelling agent present in the amorphous solid. filler

The aerosol-generating material may further comprise a filler. The use of fillers can help reduce the viscosity of amorphous solids, such as if high levels of aerosol former material are present.

Suitably, the amorphous solid comprises from about 10 wt% to about 60 wt% of a gelling agent and any optional filler.

In some embodiments, the amorphous solid may comprise less than about 50 wt% filler, such as about 1 wt% to 50 wt%, or 5 wt% to 40 wt%, or 5 wt% to 30 wt%, or 10 wt% wt% to 20 wt%.

In other embodiments, the amorphous solid comprises less than 20 wt%, suitably less than 10 wt%, or less than 5 wt% filler. In some cases, the amorphous solid contains less than 1 wt% filler, and in some cases, no filler.

The filler, if present, may comprise one or more inorganic filler materials such as calcium carbonate, perlite, vermiculite, diatomaceous earth, colloidal silica, magnesium oxide, magnesium sulfate, magnesium carbonate and suitable inorganic adsorbents such as Molecular Sieve. The filler may comprise one or more organic filler materials such as wood pulp; tobacco pulp; hemp fibers; starch and starch derivatives such as maltodextrin; chitosan; and cellulose and cellulose derivatives such as ground Cellulose, microcrystalline cellulose and nanocrystalline cellulose. In certain instances, the amorphous solid does not contain calcium carbonate, such as chalk.

It will be well understood by those skilled in the art that microcrystalline cellulose can be formed by depolymerizing cellulose through chemical processes (eg, using acids or enzymes). One exemplary method of forming microcrystalline cellulose involves acid hydrolysis of cellulose using an acid such as HCl. The cellulose produced after this treatment is crystalline (ie, no amorphous regions remain). Suitable methods and conditions for forming microcrystalline cellulose are known in the art.

In certain embodiments including fillers, the fillers are fibrous. For example, the filler may be a fibrous organic filler material such as wood pulp, tobacco pulp, hemp fibers, cellulose or cellulose derivatives. In some embodiments, the fibrous organic filler material may be wood pulp, hemp fibers, cellulose, or cellulose derivatives. In some embodiments, the fibrous filler is wood pulp. Without wishing to be bound by theory, it is generally believed that the inclusion of fibrous fillers in the amorphous solid increases the tensile strength of the material. This may be particularly advantageous in examples where the amorphous solid is provided in a sheet, such as when the sheet of amorphous solid surrounds a rod of aerosolizable material.

In some embodiments, the gelling agent is CMC and is used with wood pulp as a filler.

In some embodiments, the aerosol-generating material may further comprise one or more other functional materials.

In some embodiments, the amorphous solid may further comprise one or more additional actives and/or fragrances, and optionally one or more other functional materials. Additional active substances

In certain embodiments, a constituent, derivative or extract of cannabis is the only active ingredient present in the amorphous solid. In certain embodiments, a constituent, derivative or extract of cannabis is the only active substance present in the aerosol-generating material. However, the amorphous solid and/or aerosol-generating material may further comprise additional active ingredients.

In some cases, the amorphous solid may comprise from about 1 wt%, 5 wt%, 10 wt%, 15 wt%, 20 wt%, or 25 wt% to about 65 wt%, in addition to a component, derivative or extract of cannabis wt %, 60 wt %, 50 wt %, 45 wt %, 40 wt %, 35 wt % or 30 wt % (on a dry basis) of another active substance.

Additional active substances as used herein may be physiologically active materials, which are materials whose purpose is to achieve or enhance a physiological response. The additional active substances can be selected, for example, from nutraceuticals, nootropics and psychoactive drugs. The additional active substances may be naturally occurring or synthetically obtained. The additional active may comprise, for example, nicotine, caffeine, taurine, theophylline, vitamins such as B6 or B12 or C, melatonin, or components, derivatives or combinations thereof. The additional active may comprise one or more constituents, derivatives or extracts of tobacco or another plant.

In some embodiments, the additional active comprises nicotine.

In some embodiments, the additional active comprises caffeine, melatonin, or vitamin B12.

As described herein, the additional active may comprise or be derived from one or more plants or components, derivatives or extracts thereof. As used herein, the term "vegetable" includes any material derived from a plant, including, but not limited to, extracts, leaves, bark, fibers, stems, roots, seeds, flowers, fruits, pollen, husks, shells, or the like. Alternatively, the material may contain a synthetically obtained active compound that occurs naturally in plants. The material may be in the form of a liquid, gas, solid, powder, dust, pulverized particles, granules, granules, chips, bars, flakes, or the like. Exemplary plants are tobacco, eucalyptus, star anise, hemp, cocoa, coffee, anise, lemongrass, mint, spearmint, national treasure tea, chamomile, flax, ginger, ginkgo, hazelnut, hibiscus, bay, licorice (liquorice, Matcha, mate, orange peel, papaya, rose, sage, tea such as green or black tea, thyme, cloves, cinnamon, coffee, anise, basil, bay leaf, cardamom, coriander, cumin , nutmeg, oregano, paprika, rosemary, saffron, lavender, lemon peel, mint, juniper, elderflower, vanilla, wintergreen, perilla, turmeric, turmeric, sandalwood, Coriander, Bergamot, Orange Blossom, Myrtle, Black Currant, Valerian, Bell Pepper, Mace, Damien, Marjoram, Olive, Lemon Balm, Lemon Basil, Ezo Green Onion, Parsley Seed, Verbena, Tarragon, Geranium, Mulberry, Ginseng, Theanine, Theophylline, Maca, Ashwagandha, Damiana, Guarana, Chlorophyll, Baobab Or any combination thereof.Mint may be selected from the following mint species: wild mint ( Mentha Arventis) , mint (Mentha cv) , Egyptian mint (Mentha niliaca) , peppermint (Mentha piperita) , lemon peppermint (Mentha piperita citrata cv) , Mentha piperita cv , Mentha spicata crispa , Mentha cardifolia , Mentha longifolia , Mentha suaveolens variegate , Mentha pulegium , Green Peppermint (Mentha spicata cv) , and Apple Mint (Mentha suaveolens) .

In some embodiments, the additional active comprises or is derived from one or more plants or components, derivatives or extracts thereof, and the plant is tobacco.

In some embodiments, the additional active comprises or is derived from one or more plants or components, derivatives or extracts thereof selected from eucalyptus, star anise, cocoa and hemp. In some embodiments, the additional active comprises (or is) a plant selected from eucalyptus, star anise, cocoa and hemp.

In some embodiments, the additional active comprises or is derived from one or more plants or components, derivatives or extracts thereof, and the plants are selected from rooibos and fennel. In some embodiments, the additional active comprises (or is) a plant selected from rooibos and fennel.

For example, in some cases, the amorphous solid additionally comprises tobacco material and/or nicotine. In some cases, the amorphous solid may comprise 5-60 wt% (on a dry basis) tobacco material and/or nicotine.

In some cases, the amorphous solid can comprise from about 1 wt%, 5 wt%, 10 wt%, 15 wt%, 20 wt%, or 25 wt% to about 65 wt%, 60 wt%, 50 wt%, 45 wt% wt%, 40 wt%, 35 wt%, or 30 wt% (on a dry weight basis) of tobacco material. For example, the amorphous solid may contain up to about 50 wt% tobacco material. For example, the amorphous solid may comprise about 10-50 wt%, 15-40 wt%, or 20-35 wt% tobacco material. In some cases, the amorphous solid can comprise from about 1 wt%, 2 wt%, 3 wt%, or 4 wt% to about 20 wt%, 18 wt%, 15 wt%, or 12 wt% (on a dry basis) Calculate ) ) of nicotine. For example, the amorphous solid may contain about 1-20 wt%, 2-18 wt%, or 3-12 wt% nicotine.

In some cases, the amorphous solid contains additional actives, such as tobacco extract. In some cases, the amorphous solid may comprise 5-60 wt% (on a dry basis) tobacco extract. In some cases, the amorphous solid may comprise from about 5 wt%, 10 wt%, 15 wt%, 20 wt%, or 25 wt% to about 60 wt%, 50 wt%, 45 wt%, 40 wt%, 35 wt% wt% or 30 wt% (dry basis) of tobacco extract. For example, the amorphous solid may comprise about 10-50 wt%, 15-40 wt%, or 20-35 wt% tobacco extract. The tobacco extract may comprise a concentration of nicotine such that the amorphous solid comprises from about 1 wt%, 1.5 wt%, 2 wt% or 2.5 wt% to about 6 wt%, 5 wt%, 4.5 wt% or 4 wt% (on a dry weight basis) of nicotine. In some cases, the amorphous solid may be free of nicotine other than nicotine produced by any tobacco extract.

In some embodiments, the amorphous solids in the aerosol-generating material do not contain tobacco material but do contain nicotine. In some such cases, the amorphous solid may comprise from about 1 wt%, 2 wt%, 3 wt%, or 4 wt% to about 20 wt%, 18 wt%, 15 wt%, or 12 wt% (on a dry basis) nicotine calculated as a benchmark). For example, the amorphous solid may contain about 1-20 wt%, 2-18 wt%, or 3-12 wt% nicotine.

In some embodiments, the amorphous solid and aerosol-generating material do not contain any tobacco material (including tobacco extract) or nicotine.

In some embodiments, the amorphous solid does not contain tobacco fibers. In certain embodiments, the amorphous solid contains no fibrous material.

In some embodiments, the aerosol-generating material does not contain tobacco fibers. In certain embodiments, the aerosol-generating material does not contain fibrous material. spices

The amorphous solid and/or aerosol-generating material may optionally contain a fragrance. For example, the amorphous solid may contain up to about 65 wt%, 55 wt%, 50 wt%, or 45 wt% fragrance. In some cases, the amorphous solid can comprise at least about 0.1 wt%, 1 wt%, 10 wt%, 20 wt%, 30 wt%, 35 wt%, or 40 wt% perfume (on a dry basis) . For example, the amorphous solid may contain 1-65 wt%, 10-65 wt%, 20-50 wt%, or 30-40 wt% fragrance.

As used herein, the terms "flavors" and "flavors" refer to materials that, where permitted by local regulations, can be used to create a desired taste, aroma, or other somatosensory sensation in a product for an adult consumer. They may include naturally occurring flavoring materials, plants, plant extracts, synthetically obtained materials, or combinations thereof (eg, tobacco, hemp, licorice (liquorice), hydrangea, eugenol, Japanese white bark magnolia leaves, Chamomile, Fenugreek, Cloves, Maple, Matcha, Menthol, Japanese Mint, Star Anise (Anise), Cinnamon, Turmeric, Indian Spices, Asian Spices, Vanilla, Wintergreen, Cherry, Berries, Redcurrants, Cranberries, Peach , apple, orange, mango, clementine, lemon, lime, tropical fruit, papaya, rhubarb, grape, durian, dragon fruit, cucumber, blueberry, mulberry, citrus fruit, Doolin liqueur ( Drambuie), bourbon, scotch, whiskey, gin, tequila, rum, spearmint, mint, lavender, aloe vera, cardamom, celery, cascarilla, nutmeg, sandalwood , bergamot, geranium, khat, naswar, betel nut, shisha, pine, honey extract, rose oil, vanilla, lemon oil, orange oil, orange blossom, cherry blossom, cassia, incense Celery Seed, Cognac, Jasmine, Ylang Ylang-Ylang-Ylang, Sage, Fennel, Mustard, Chili Pepper, Ginger, Coriander, Coffee, Hemp, Peppermint Oil from Any Species of Mentha, Eucalyptus, Star Anise, Cocoa, Lemongrass , national treasure tea (rooibos), flax, ginkgo, hazelnut, hibiscus, bay, mate, orange peel, rose, tea (such as green or black tea), thyme, juniper, elderflower, basil, bay leaf , cumin, oregano, paprika, rosemary, saffron, lemon zest, mint, basil, turmeric, coriander, myrtle, black currant, valerian, bell pepper, mace, damian (damien), marjoram, olive, lemon balm, lemon basil, scallion, caraway, verbena, tarragon, limonene, thymol, camphene), flavor enhancer, bitter receptor site blocker agents, sensory receptor site activators or stimulants, sugars and/or sugar substitutes (e.g. sucralose, potassium sultone, aspartame, saccharin, cyclamate, lactose, sucrose, glucose , fructose, sorbitol or mannitol), and other additives such as charcoal, chlorophyll, minerals, botanicals or breath fresheners. They can be imitations, synthetic or natural ingredients or mixtures thereof. They may be in any suitable form, eg liquids such as oils, solids such as powders, or gases.

In some embodiments, the fragrance comprises menthol, spearmint and/or peppermint.

In some embodiments, the flavor comprises cucumber, blueberry, citrus fruit and/or cranberry flavor components.

In some embodiments, the fragrance comprises eugenol.

In some embodiments, the flavor comprises flavor components extracted from tobacco.

In some embodiments, the flavor comprises flavor components extracted from cannabis.

In some embodiments, the fragrance may include sensates for use in obtaining somatosensory sensations, typically chemically induced and perceived by stimulation of the fifth cranial nerve (trigeminal nerve), to additionally or in place of the fragrance Or taste nerves, these may include agents that provide heating, cooling, tingling, numbing effects. A suitable thermal effect agent can be, but is not limited to, vanillyl ether, and a suitable coolant can be, but is not limited to, eucalyptol or WS-3( N -ethyl-2-isopropyl-5-methylcyclohexanemethyl) amide).

In some cases, the amorphous solid may additionally contain an emulsifier, which emulsifies the molten flavor during manufacture. For example, the amorphous solid may contain from about 5 wt % to about 15 wt % emulsifier (on a dry basis), suitably about 10 wt %. Emulsifiers can include gum arabic.

In some cases, the total content of the additional active and/or fragrance may be at least about 0.1 wt%, 1 wt%, 5 wt%, 10 wt%, 20 wt%, 25 wt%, or 30 wt%. In some cases, the total content of additional actives and/or fragrances may be less than about 60 wt%, 50 wt%, or 40 wt% (all on a dry weight basis).

In some cases, the total content of tobacco material, nicotine, and/or flavor may be at least about 0.1 wt%, 1 wt%, 5 wt%, 10 wt%, 20 wt%, 25 wt%, or 30 wt%. In some cases, the total content of tobacco material, nicotine, and/or flavor may be less than about 60 wt%, 50 wt%, or 40 wt% (all on a dry weight basis). Other functional materials

The one or more other functional materials may include one or more of pH adjusters, colorants, preservatives, stabilizers, and/or antioxidants.

In some embodiments, the amorphous solid is formed in a sheet. In some cases, the amorphous solid sheet can be integrated into the non-combustible aerosol supply system, or consumed in sheet form. The amorphous solid sheet may be incorporated in flat sheet form, aggregated or bundled sheet form, curled sheet or rolled sheet (ie, tubular form). In some such cases, the amorphous solids of these embodiments may be incorporated into the system/consumable as a sheet, such as a sheet surrounding a rod of aerosolizable material (eg, tobacco). For example, an amorphous solid sheet can be formed on a roll of paper that surrounds an aerosolizable material such as tobacco. In other cases, the sheet may be shredded and then integrated into an assembly, suitably mixed into an aerosolizable material such as shredded tobacco.

In some cases, the amorphous solid may be in the form of a sheet or layer having a thickness of about 0.015 mm to about 1.0 mm. Suitably, the thickness may range from about 0.05 mm, 0.1 mm or 0.15 mm to about 0.5 mm or 0.3 mm, eg 0.1 to 3 mm or 0.15 to 3 mm. Materials with a thickness of 0.2 mm may be particularly suitable. The amorphous solid may comprise more than one layer, and the thicknesses described herein refer to the stack thickness of these layers.

If the amorphous solid is too thick, heating efficiency may be affected. This can adversely affect power consumption in use. Conversely, if the amorphous solid is too thin, it can be difficult to manufacture and handle; very thin materials are more difficult to cast, and can be fragile, affecting aerosol formation in use.

The thickness specified here is the average thickness of the material. In some cases, the amorphous solid thickness may vary by no more than 25%, 20%, 15%, 10%, 5%, or 1%.

In some examples, the amorphous solid in sheet form can have a tensile strength of about 200 N/m to about 2000 N/m. In some examples, the amorphous solid in sheet form can have a tensile strength of about 200 N/m to about 900 N/m. In some examples, such as where the amorphous solid contains no filler, the tensile strength of the amorphous solid in sheet form may be from about 200 N/m to about 400 N/m, or about 200 N/m m to about 300 N/m, or about 250 N/m. This tensile strength may be particularly suitable for embodiments in which the amorphous solid and/or aerosol-generating material is formed as a sheet, which is then chopped and incorporated into a consumable. In some examples, such as where the amorphous solid includes a filler, the amorphous solid can have about 600 N/m to about 900 N/m, or about 700 N/m to about 900 N/m, or about Tensile strength of 800 N/m. This tensile strength may be particularly suitable for embodiments in which the amorphous solid and/or aerosol-generating material is contained in the consumable/non-combustible aerosol supply system as a rolled sheet (suitably in tubular form) .

The aerosol-generating material comprising the amorphous solid may have any suitable areal density, such as 30 g/m ² to 120 g/m ² . In some cases, the mass per unit area of the aerosol-generating material may be 80 to 120 g/m ² , or about 70 to 110 g/m ² , especially about 90 to 110 g/m ² or suitably about 100 g/m 2 g/m ² (making it a similar density to shredded tobacco, and a mixture of these substances does not separate easily). This areal density may be particularly suitable when the aerosol-generating material is included in an assembled consumable/system in sheet form or cut sheet form (described further below). In some cases, the mass per unit area of the aerosol-generating material can be about 30 to 70 g/m ² , 40 to 60 g/m ² , or 25 to 60 g/m ² , and can be used to wrap the aerosolizable material , such as tobacco.

The amorphous solid used to generate the aerosol may be present on or within the support to form the substrate. The support can be or comprise, for example, paper, card, cardboard, cardboard, reconstituted material, plastic material, ceramic material, composite material, glass, metal or metal alloy. In some embodiments, the support includes a susceptor. In some embodiments, the susceptor is embedded within the material. In some alternative embodiments, the susceptor is located on one or either side of the material.

The aerosol-generating material may comprise a carrier on which an amorphous solid is provided. The carrier acts as a support, on which an amorphous solid layer is formed, and is easy to manufacture. The support can provide tensile strength to the amorphous solid layer while being easy to handle.

In some cases, the support may be formed from a material selected from the group consisting of metal foil, paper, carbon paper, greaseproof paper, ceramic, carbon allotropes such as graphite and graphene, plastic, cardboard, wood, or combinations thereof. In some cases, the carrier may comprise or consist of tobacco material, such as a reconstituted tobacco sheet. In some cases, the carrier may be formed from a material selected from metal foil, paper, cardboard, wood, or combinations thereof. In some cases, the carrier itself is a layered structure comprising layers of materials selected from the aforementioned lists. In some cases, the carrier may also function as a fragrance carrier. For example, the carrier may be impregnated with flavor or tobacco extract.

In some cases, the carrier may be magnetic. This function can be used to secure the carrier to a non-combustible aerosol supply in use, or can be used to create specific amorphous solid shapes. In some cases, the aerosol-generating material may contain one or more magnets, which may be used to secure the material to the induction heater in use.

In some cases, the carrier may be substantially or completely impermeable to gases and/or aerosols. This prevents the aerosol or gas from passing through the carrier layer, thus controlling the flow and ensuring its delivery to the user. This can also be used to prevent condensation or other kinds of deposits of the gas/aerosol in use on the surface of a heater such as provided in the aerosol generating assembly. Therefore, consumption efficiency and hygiene can be improved in some cases.

In some cases, the surface of the support supporting the amorphous solid can be porous. For example, in one instance, the carrier comprises paper. Porous supports such as paper have been found to be particularly suitable; the porous (eg paper) layer supports the amorphous solid layer and forms strong bonds. The amorphous solid may be formed by drying the gel, and without being bound by theory, it is believed that the gel-forming slurry partially impregnates the porous support (eg, paper) such that when the gel solidifies, the support is partially bound into the gel. This provides strong binding between the gel and the carrier (and between the dried gel and the carrier).

In some embodiments, the amorphous solid can be laminated to a support (eg, a sheet of paper).

In some embodiments, when the amorphous solid is formed from a slurry as described herein, the slurry layer can be formed on a support (eg, a paper sheet).

In addition, the surface roughness may contribute to the bond strength between the amorphous material and the support. The inventors have found that the paper roughness (for the surface supporting the carrier) may suitably be in the range of 50 to 1000 Bekk seconds, suitably 50 to 150 Bekk seconds, suitably 100 Bekk seconds (tie at measured at air pressure intervals of 50.66 to 48.00 kPa). (The Bekk smoothness tester is an instrument used to determine the smoothness of a paper surface where air at a specified pressure leaks between a smooth glass surface and a sample of paper, and the time (in seconds) between the penetration of a fixed volume of air into these surfaces Units) is "Bekk smoothness".)

Conversely, the surface of the carrier remote from the amorphous solid can be configured to be in contact with the heater, and a smoother surface can provide more efficient heat transfer. Thus, in some cases, the carrier is configured to have a rougher side supporting the amorphous material and a smoother side remote from the amorphous material.

In a particular case, the carrier may be a paper backed foil; the paper layer supports the amorphous solid layer, and the properties discussed in the preceding paragraphs are provided by this support substrate. The foil backing is substantially impermeable, thus providing control over the flow path of the aerosol. A metal foil backing can also be used to conduct heat to the amorphous solid.

In another instance, the foil layer of the paper backing foil supports the amorphous solid. The foil is substantially impermeable, thus preventing water provided in the amorphous solid from being absorbed into the paper, which would weaken its structural integrity.

In some cases, the carrier is formed from or includes a metal foil, such as aluminum foil. A metal support may allow better conduction of thermal energy to the amorphous solid. Additionally or alternatively, metal foils can act as susceptors in induction heating systems. In certain embodiments, the carrier comprises a metal foil layer and a support layer, such as cardboard. In these embodiments, the metal foil layer may have a thickness of less than 20 μm, such as about 1 μm to about 10 μm, suitably about 5 μm.

In some cases, the carrier may have a thickness of between about 0.010 mm to about 2.0 mm, suitably from about 0.015 mm, 0.02 mm, 0.05 mm, or 0.1 mm to about 1.5 mm, 1.0 mm, or 0.5 mm. consumables

In another aspect of the present invention, there is provided a consumable for use in a non-flammable aerosol providing device, the consumable comprising an aerosol-generating material, wherein the aerosol-generating material comprises an amorphous solid, the amorphous Mass solids contain: From about 1 to about 12 wt% cannabis constituents, derivatives or extracts; from about 10 to about 80 wt % of the aerosol former material; gelling agent; and optional fillers, wherein the total amount of gelling agent and optional filler is from about 10 to about 60 wt%; The wt% value is calculated on the basis of dry weight.

In some embodiments, the present invention relates to consumables containing aerosol-generating material and configured for use with a non-flammable aerosol supply. These consumables are sometimes referred to in this disclosure as items.

This consumable can be used with any suitable non-flammable aerosol supply.

The consumable is an item containing or consisting of an aerosol-generating material, some or all of which is intended to be consumed by a user during use. The consumable may include one or more other components, such as aerosol-generating material storage areas, aerosol-generating material transport components, aerosol-generating areas, housings, rolls, suction nozzles, filters, and/or aerosol modifiers. The consumable may also contain an aerosol generator, such as a heater, which emits heat to cause the aerosol-generating material to generate an aerosol in use. For example, the heater may comprise a combustible material, a material that can be heated by electrical conduction, or a susceptor.

A susceptor is a material that can be heated by passing through a changing magnetic field, such as an alternating magnetic field. The susceptor may be an electrically conductive material such that its passage through the changing magnetic field induces inductive heating of the heated material. The heating material may be a magnetic material such that its passage through a changing magnetic field induces hysteretic heating of the heating material. The susceptor can be both conductive and magnetic, so the susceptor can be heated by both heating mechanisms. A device configured to generate a varying magnetic field is referred to herein as a magnetic field generator.

An aerosol modifier is a substance, typically located downstream of the aerosol-generating region, that is configured to modify the generated aerosol, for example by altering the taste, aroma, acidity or other properties of the aerosol. The aerosol modifier can be provided in an aerosol modifier release element operable to selectively release the aerosol modifier.

The aerosol modifier can be, for example, an additive or absorbent. The aerosol modifier may, for example, comprise one or more of fragrance, colorant, water and carbon absorber. The aerosol modifier can be, for example, a solid, liquid or gel. The aerosol modifier may be in powder, thread or granular form. The aerosol modifier may be free of filter material.

The aerosol generator is a device configured to cause an aerosol to be generated from an aerosol-generating material. In some embodiments, the aerosol generator is a heater configured to subject the aerosol-generating material to thermal energy to release one or more volatiles from the aerosol-generating material to form an aerosol. In some embodiments, the aerosol generator is configured to generate an aerosol from the aerosol-generating material without heating. For example, the aerosol generator may be configured to subject the aerosol-generating material to one or more of vibration, pressure, or electrostatic energy. Non-flammable aerosol supply system

In another aspect of the present invention, there is provided a non-combustible aerosol supply system comprising the consumables described herein and a non-combustible aerosol supply device.

According to the present disclosure, a "non-combustible" aerosol supply system is one in which the constituent aerosol-generating material of the aerosol supply system (or elements thereof) facilitates delivery of at least one substance to a user through combustion or incineration. Fog supply system.

In some embodiments, the delivery system is a non-flammable aerosol supply system, such as a powered non-flammable aerosol supply system.

In some embodiments, the non-combustible aerosol supply system is an aerosol-generating material heating system, also known as a heat or burn system. An example of such a system is a tobacco heating system.

In some embodiments, the non-flammable aerosol supply device is a heat or burn device.

In some embodiments, the non-combustible aerosol supply system is a hybrid system to generate an aerosol using a combination of aerosol-generating materials, one or more of which may be heated. In some embodiments, the hybrid system comprises an aerosol-generating material as described herein, comprising or consisting of an amorphous solid and an additional liquid or gel aerosol-generating material.

In some embodiments, the non-flammable aerosol providing device is an electronic cigarette mixing device.

Typically, the non-combustible aerosol supply system may include a non-combustible aerosol supply and consumables for use with the non-combustible aerosol supply.

In some embodiments, the non-combustible aerosol supply system, such as its non-combustible aerosol supply device, may include an energy source and a controller. For example, the energy source may be an electrical energy source or an exothermic energy source. In some embodiments, the exothermic energy source comprises a carbon substrate that can be charged to distribute energy in the form of thermal energy to the aerosol-generating material or thermally conductive material in the vicinity of the exothermic energy source.

In some embodiments, the non-combustible aerosol supply system, such as its non-combustible aerosol supply, may include an area for receiving consumables, an aerosol generator, an aerosol-generating area, a housing, a mouthpiece, a filter and/or aerosol modifiers.

The non-combustible aerosol supply system or device may comprise a heater configured to heat but not burn the aerosol-generating substrate. In some cases, the heater can be a thin film resistive heater. In other cases, the heater may comprise an induction heater or the like. In other cases, the heater may be a combustible heat source or a chemical heat source, which in use undergoes an exothermic reaction to generate heat.

In some cases, the heater may heat the aerosolizable material to between 120ºC and 350ºC in use without burning it. In some cases, the heater may heat the aerosolizable material to between 140ºC and 250ºC in use without burning it. In some cases in use, substantially all of the amorphous solid is less than about 4 mm, 3 mm, 2 mm, or 1 mm from the heater. In some cases, the solid is disposed between about 0.017 mm and 2.0 mm from the heater, suitably between about 0.1 mm and 1.0 mm. In some cases, these minimum distances may reflect the thickness of the carrier supporting the amorphous solid. In some cases, the surface of the amorphous solid can directly support the heater.

In some cases, the heater may be embedded in the aerosol-generating material. In some such cases, the heater may be a resistive heater (with exposed contacts for connection to the circuit). In other such cases, the heater may be a susceptor embedded in the aerosol-generating material, which is heated by induction.

The non-flammable aerosol supply system may additionally comprise cooling elements and/or filters. The cooling element, if present, can be used to cool the gas or aerosol composition. In some cases, it can act to cool gaseous components, causing them to condense to form aerosols. It also acts to isolate very hot parts of the device from the user. The filter, if present, may comprise any suitable filter known in the art, such as a cellulose acetate plug.

In some cases, the non-combustible aerosol supply system may be a heat-not-burn system. That is, it may contain solid material (and no liquid aerosolizable material). A heat not burn device is disclosed in WO 2015/062983 A2, which is hereby incorporated by reference in its entirety.

In some cases, the non-combustible aerosol supply system may include an electronic cigarette mixing device. That is, it may contain solid aerosolizable materials and liquid aerosolizable materials. A separate aerosolizable material may be heated by a separate heater, the same heater, or in one case, a downstream aerosolizable material may be heated by a hot aerosol generated from an upstream aerosolizable material. An electronic cigarette mixing device is disclosed in WO 2016/135331 A1, which is hereby incorporated by reference in its entirety.

The consumable is alternatively referred to herein as a cassette. This consumable can be adapted to THP, e-cigarette mixing devices, or other aerosol-generating devices. In some cases, the consumable may additionally include filters and/or cooling elements, as previously described. In some cases, the consumable may be surrounded by packaging material (eg, paper).

This consumable can additionally contain vents. These can be provided in the side walls of the object. In some cases, the ventilation holes may be provided in the filter and/or cooling element. These holes may allow cool air to be drawn into the article during use, which may mix with the heated volatile components thereby cooling the aerosol.

The ventilation enhances the generation of visible heating volatiles in the article when the article is heated in use. The process of cooling the heated volatile components makes the heated volatile components visible, and causes the heated volatile components to produce supersaturation. The heated volatiles then undergo droplet formation, also known as nucleation, and finally the size of the heated volatiles aerosol particles will be further condensed by the heated volatiles and newly formed from the heated volatiles. The droplets coagulate and increase.

In some cases, the ratio of cool air to the sum of heated volatiles and cool air, known as the ventilation rate, is at least 15%. A ventilation rate of 15% makes the heated volatiles visible by the method described above. The visibility of the heated volatiles enables the user to recognize that the volatiles have been generated and adds to the sensory experience of the smoking experience.

In another example, the ventilation rate is between 50% and 85% to provide additional cooling of the heated volatiles. In some cases, the ventilation rate may be at least 60% or 65%.

1 and 2, partial cutaway cross-sectional and perspective views of an example of an article consumable 101 ("article") are shown. Article 101 is suitable for use with a device having an energy source and a heater. The article 101 of this embodiment is particularly suitable for use with the device 51 shown in Figures 5-7, as described below. In use, the article 101 can be removably inserted into the device shown in FIG. 5 at the insertion point 20 of the device 51 .

The article 101 in one example is in the form of a substantially cylindrical rod that includes a body 103 of aerosol-generating material and a filter assembly 105 in the form of a rod. The aerosol-generating material includes the amorphous solid materials described herein. In some embodiments, it may be included in sheet form. In some embodiments, it may be included in the form of fragments. In some embodiments, the aerosol-generating materials described herein can be incorporated in sheet and shredded form.

Filter assembly 105 includes three sections, cooling section 107 , filter section 109 and mouth end section 111 . The article 101 has a first end 113, also known as the mouth end or proximal end, and a second end 115, also known as the distal end. The body of aerosol-generating material 103 is positioned towards the distal end 115 of the article 101 . In one example, the cooling section 107 is immediately adjacent to the aerosol-generating material body 103 , between the aerosol-generating material body 103 and the filter section 109 , such that the cooling section 107 is adjacent to the aerosol-generating material 103 and the filter section 103 . relation. In other examples, there may be a gap between the body of aerosol-generating material 103 and the cooling section 107, and a gap between the body of aerosol-generating material 103 and the filter section 109. The filter section 109 is located between the cooling section 107 and the mouth end section 111. The mouth end section 111 is positioned towards the proximal end 113 of the article 101 adjacent to the filter section 109 . In one example, the filter section 109 is in an adjoining relationship with the mouth end section 111 . In one embodiment, the overall length of the filter assembly 105 is between 37 mm and 45 mm, more preferably the overall length of the filter assembly 105 is 41 mm.

In one example, the length of the aerosol-generating material rod 103 is between 34 mm and 50 mm, suitably between 38 mm and 46 mm, suitably 42 mm.

In one example, the overall length of the object 101 is between 71 mm and 95 mm, suitably between 79 mm and 87 mm, suitably 83 mm.

The axial end of the aerosol-generating material body 103 is visible at the distal end 115 of the article 101 . However, in other embodiments, the distal end 115 of the article 101 may comprise an end element (not shown) that covers the axial end of the body of the aerosol-generating material 103 .

The aerosol-generating material body 103 is attached to the filter assembly 105 by an annular tipping base paper (not shown) that substantially surrounds the circumference of the filter assembly 105 to surround the filter assembly 105 and partially extend along the length of the aerosol-generating material body 103 . In one example, the slanted backing paper is made of a 58GSM standard slanted backing paper. In one example, the length of the sloped backing paper is between 42 mm and 50 mm, suitably 46 mm.

In one example, the cooling section 107 is an annular tube and is positioned around the cooling section and defines an air gap within the cooling section. The air gap provides a chamber through which heated volatile components generated from the body 103 of aerosol-generating material can flow. Cooling section 107 is hollow to provide a chamber for aerosol accumulation, but rigid enough to withstand axial compressive forces and bending moments that may arise during manufacturing and during use of article 101 inserted into device 51 . In one example, the thickness of the cooling section 107 walls is approximately 0.29 mm.

Cooling section 107 provides physical displacement between aerosol-generating material 103 and filter section 109 . The physical displacement provided by cooling section 107 will provide a thermal gradient across the length of cooling section 107 . In one example, the cooling section 107 is configured to provide a temperature differential of at least 40 degrees Celsius between the heated volatiles entering the first end of the cooling section 107 and the heated volatiles exiting the second end of the cooling section 107 . In one example, the cooling section 107 is configured to provide a temperature differential of at least 60 degrees Celsius between the heated volatiles entering the first end of the cooling section 107 and the heated volatiles exiting the second end of the cooling section 107 . This temperature differential across the length of the cooling element 107 may protect the temperature sensitive filter section 109 from high temperature damage when the aerosol-generating material 103 is heated by the device 51 . If no physical displacement is provided between the filter segment 109 and the aerosol-generating material body 103 and the device heating element 51, the temperature sensitive filter segment 109 may be damaged in use and thus not be able to effectively perform its desired function.

In one example, the length of the cooling section 107 is at least 15 mm. In one example, the length of the cooling section 107 is between 20 mm and 30 mm, more particularly 23 mm to 27 mm, more particularly 25 mm to 27 mm, suitably 25 mm.

Cooling section 107 is made of paper, which means that it is constructed of a material that does not generate compounds of interest, such as toxic compounds, when used adjacent to device heater 51 . In one example, the cooling section 107 is made from a helically wound paper tube that provides a hollow interior but still maintains mechanical stiffness. Spiral wound paper tubes can meet the stringent dimensional accuracy requirements of high-speed manufacturing processes for tube length, outer diameter, roundness and straightness.

In another example, the cooling section 107 is a groove created by stiff plug wrap or threading paper. The stiff plug wrap or tipping paper is manufactured with sufficient stiffness to withstand axial compressive forces and bending moments that may arise during the manufacturing process and during use of the article 101 in the insertion device 51 .

Filter section 109 may be formed from any filter material sufficient to remove one or more volatile compounds from the heated volatile components of the aerosol-generating material. In one example, the filter section 109 is made of a monoacetate material, such as cellulose acetate. Filter section 109 provides cooling and reduces irritation from the heated volatiles without depleting the amount of heated volatiles to levels unsatisfactory to the user.

In some embodiments, capsules (not shown) may be provided in filter section 109 . It may be positioned substantially in the center of filter segment 109 , both across the diameter of filter segment 109 and along the length of filter segment 109 . In other cases, it can be offset in one or more dimensions. In some cases, the capsules may contain volatile ingredients, if present, such as fragrances or aerosol-forming materials.

The density of the cellulose acetate tow material of the filter section 109 controls the pressure drop at both ends of the filter section 109 , thereby controlling the tensile resistance of the object 101 . Therefore, the material selection of the filter section 109 is very important to control the suction resistance of the object 101 . In addition, the filter section performs the filtering function in object 101 .

In one example, the filter section 109 is made of grade 8Y15 filter tow material, which provides a filtering effect on the heated volatile material while also reducing the size of the condensed aerosol droplets produced by the heated volatile material.

The presence of filter section 109 provides an insulating effect by providing further cooling to the heated volatiles exiting cooling section 107. This further cooling effect reduces the contact temperature of the user's lips on the filter section 109 surface.

In one example, the length of the filter section 109 is between 6 mm and 10 mm, suitably 8 mm.

The mouth end section 111 is an annular tube surrounding and defining an air gap within the mouth end section 111 . The air gap provides a chamber through which heated volatiles generated from filter section 109 can flow. The mouth end section 111 is hollow to provide a chamber for aerosol accumulation, but rigid enough to withstand axial compressive forces and bending that may occur during manufacturing and during use in the article insertion device 51 moment. In one example, the thickness of the walls of the mouth end section 111 is about 0.29 mm. In one example, the length of the mouth end section 111 is between 6 mm and 10 mm, suitably 8 mm.

The mouth end section 111 is made from a helically wound paper tube that provides a hollow interior but still maintains mechanical stiffness. Spiral wound paper tubes can meet the stringent dimensional accuracy requirements of high-speed manufacturing processes for tube length, outer diameter, roundness and straightness.

The mouth end section 111 provides the function of preventing any liquid condensate that accumulates at the outlet of the filter section 109 from coming into direct contact with the user.

It will be appreciated that in one example, the mouth end section 111 and the cooling section 107 may be formed from a single tube, and the filter section 109 is located within the single tube separating the mouth end section 111 and the cooling section 107 .

Please refer to FIGS. 3 and 4, which show partial cutaway cross-sectional and perspective views of an example of object 301. The reference symbols shown in Figures 3 and 4 are identical to the reference symbols shown in Figures 1 and 2, but increased by 200.

In the example of the article 301 shown in FIGS. 3 and 4 , a ventilation area 317 is provided in the article 301 to enable air from the outside of the article 301 to flow into the inside of the article 301 . In one example, the ventilation area 317 takes the form of one or more ventilation holes 317 formed through the outer layer of the article 301. Ventilation holes may be located in cooling section 307 to aid in the cooling of item 301 . In one example, the ventilation area 317 includes one or more rows of holes, and preferably, each row of holes is arranged around the periphery of the object 301 in a cross-section substantially perpendicular to the longitudinal axis of the object 301 .

In one example, there are one to four rows of ventilation holes to provide ventilation for the object 301 . Each row of vents may have 12 to 36 vents 317 . The diameter of the ventilation holes 317 may be, for example, between 100 and 500 μm. In one example, the axial spacing between the rows of vent holes 317 is between 0.25 mm and 0.75 mm, suitably 0.5 mm.

In one example, the ventilation holes 317 are of the same size. In another example, the dimensions of the vents 317 are different. The vents may be made using any suitable technique, such as one or more of the following: laser technology, mechanical perforation of cooling section 307 , or pre-perforation of cooling section 307 before it forms object 301 . The vents 317 are positioned to provide effective cooling of the article 301 .

In one example, the rows of ventilation holes 317 are located at least 11 mm from the proximal end 313 of the object, suitably between 17 mm and 20 mm from the proximal end 313 of the object 301 . The location of the ventilation holes 317 is positioned so that the user does not block the ventilation holes 317 when using the article 301 .

Providing multiple rows of ventilation holes between 17 mm and 20 mm from the proximal end 313 of the object 301 allows the ventilation holes 317 to be located outside the device 51 when the object 301 is fully inserted into the device 51, as shown in Figures 6 and 7 shown. By locating the vents outside the device, unheated air can enter the object 301 from outside the device 51 through the vents to aid in the cooling of the object 301 .

The length of the cooling section 307 is such that when the article 301 is fully inserted into the apparatus 51, the cooling section 307 is partially inserted into the apparatus 51. The length of the cooling section 307 provides the first function of providing a physical gap between the device of the device heater 51 and the thermally sensitive filter device 309, as well as allowing the ventilation holes 317 to be located in the cooling section when the item 301 is fully inserted into the device 51 while also A second function that is external to the device 51 . As shown in FIGS. 6 and 7 , most of the cooling element 307 is located within the device 51 . However, a portion of the cooling element 307 extends from the device 51 . This portion of the cooling element 307 extends from the device 51 where the ventilation holes 317 are located.

Referring now in more detail to FIGS. 5-7, there is shown an example of a device 51 configured to heat the aerosol-generating material to volatilize at least one component of the aerosol-generating material, typically to form a respirable aerosol . Device 51 is a heating device that releases the compound by heating rather than burning the aerosol-generating material.

The first end 53 is sometimes referred to herein as the mouth or proximal end 53 of the device 51 , and the second end 55 is sometimes referred to herein as the distal end 55 of the device 51 . The device 51 has an on/off button 57 to allow the device 51 to be turned on and off as desired by the user.

Device 51 includes a housing 59 for locating and protecting the various internal components of device 51 . In the example shown, the housing 59 includes an integrally formed sleeve 11 that surrounds the perimeter of the device 51, with a top plate 17 (which generally defines the "top" of the device 51) and a bottom plate 19 (which generally defines the device 51 "bottom") cover. In another example, in addition to the top panel 17 and the bottom panel 19, the enclosure includes a front panel, a rear panel, and a pair of opposing side panels.

The top plate 17 and/or the bottom plate 19 may be removably secured to the integrally formed sleeve 11 to allow easy access to the interior of the device 51, or may be "permanently" secured to the integrally formed sleeve 11, for example to prevent The user accesses the interior of the device 51 . In one example, the plates 17 and 19 are made of plastic material, including glass-filled nylon formed by injection molding, for example, and the one-piece sleeve 11 is made of aluminum, although other materials and other manufacturing methods may be used.

The top plate 17 of the device 51 has an opening 20 at the mouth end 53 of the device 51 through which, in use, objects 101, 301 comprising the aerosol-generating material can be inserted into the device 51 and removed from the device 51 by the user Move out.

Housing 59 has heater means 23, control circuitry 25 and energy source 27 located or secured therein. In this example, heater device 23, control circuit 25, and energy source 27 are laterally adjacent (ie, adjacent when viewed from one end), with control circuit 25 typically located between heater device 23 and energy source 27, but other locations It is also possible.

The control circuit 25 may include a controller, such as a microprocessor device, configured and arranged to control the heating of the aerosol-generating material in the articles 101, 301, as discussed further below.

The energy source 27 can be, for example, a battery, which can be a rechargeable battery or a non-rechargeable battery. Examples of suitable batteries include, for example, lithium ion batteries, nickel batteries (eg, nickel cadmium batteries), alkaline batteries, and/or the like. A battery 27 is electrically coupled to the heater device 23 to provide power when needed and under the control of the control circuit 25 to heat the aerosol-generating material in the article (as discussed above, to volatilize the aerosol-generating material without causing The aerosol-generating material burns).

An advantage of locating the energy source 27 laterally adjacent to the heater device 23 is that a physically large energy source 25 can be used without making the device 51 as a whole unduly redundant. As will be appreciated, generally the physically larger energy source 25 has a higher capacity (ie, the total electrical energy that can be supplied, usually in ampere-hours or the like), so the battery life of the device 51 can be longer.

In one example, the heater device 23 is generally in the form of a hollow cylindrical tube with a hollow interior heating chamber 29 into which the article 101, 301 containing the aerosol-generating material can be inserted for heating in use. The heater device 23 can use different configurations. For example, heater device 23 may comprise a single heating element or may be formed from a plurality of heating elements aligned along the longitudinal axis of heater device 23 . The or each heating element may be annular or tubular, or at least partially annular or partially tubular around it. In one example, the or each heating element may be a thin film heater. In another example, the or each heating element may be made of a ceramic material. Examples of suitable ceramic materials include alumina and aluminum nitride and silicon nitride ceramics, which can be laminated and sintered. Other heating means are also possible, including, for example, induction heating, infrared heating elements that heat by emitting infrared radiation, or resistive heating elements formed, for example, by electrical resistance winding.

In one particular example, heater device 23 is supported by a stainless steel support tube and includes a polyimide heating element. The size of the heater device 23 is such that substantially the entire body of the aerosol-generating material 103, 303 of the article 101, 301 is inserted into the heater device 23 when the article 101, 301 is inserted into the device 51.

The or each heating element may be configured such that selected areas of the aerosol-generating material may be heated independently, eg sequentially (over time, as described above) or together (simultaneously) as desired.

The heater device 23 in this example is surrounded by insulation 31 along at least a portion of its length. Insulator 31 helps reduce heat transfer from heater device 23 to the outside of device 51 . This helps reduce the power requirements of the heater unit 23 as it generally reduces heat losses. Insulator 31 also helps keep the exterior of device 51 cool during operation of heater device 23 . In one example, the thermal insulator 31 may be a double-walled sleeve that provides an area of low pressure between the two walls of the sleeve. That is, the thermal insulator 31 may be, for example, a "vacuum" tube, ie, that has been at least partially evacuated to minimize thermal energy transfer by conduction and/or convection. In addition to or in place of the double-walled sleeve, other configurations of the insulator 31 may be used, including the use of insulating materials, including, for example, suitable foam-type materials.

Housing 59 may also contain various internal support structures 37 for supporting all internal components and heating device 23 .

Device 51 further includes a collar 33 extending around opening 20 and projecting from opening 20 into the interior of housing 59 , and a generally tubular chamber 35 located between collar 33 and one end of vacuum sleeve 31 . The chamber 35 further includes a cooling structure 35f comprising a plurality of cooling fins 35f spaced along the outer surface of the chamber 35 , and each cooling fin is circumferentially arranged around the outer surface of the chamber 35 . There is an air gap 36 between the hollow chamber 35 and the articles 101 , 301 which, when inserted into the device 51 , will be located over at least a portion of the length of the hollow chamber 35 . The air gap 36 surrounds the entire circumference of the articles 101, 301 and over at least a portion of the cooling section 307. .

Collar 33 includes a plurality of ridges 60 arranged circumferentially around the perimeter of opening 20 and projecting into opening 20 . Ridges 60 occupy space within openings 20 such that openings 20 where there are ridges 60 have a smaller opening span than openings 20 where there are no ridges 60. Ridges 60 are configured to engage objects 101, 301 inserted into the device to help secure them within device 51. The open space (not shown) defined by the adjacent pairs of ridges 60 and the objects 101 , 301 forms a ventilation path around the exterior of the objects 101 , 301 . These ventilation paths allow hot steam that has escaped from the objects 101 , 301 to leave the device 51 and allow cooling air to flow into the device 51 around the objects 101 , 301 in the air gap 36 .

In operation, the articles 101 , 301 are removably inserted into the insertion point 20 of the device 51 as shown in FIGS. 5-7 . Referring in particular to FIG. 6 , in one example, the body of aerosol-generating material 103 , 303 , which is positioned toward the distal end 115 , 315 of the article 101 , 301 , is fully contained within the heater device 23 of the device 51 . The proximal ends 113, 313 of the objects 101, 301 extend from the device 51 and serve as a mouth end assembly for use by the user.

In operation, the heater device 23 will heat the articles 101 , 301 to volatilize at least one component of the aerosol-generating material from the body of the aerosol-generating material 103 , 303 .

The main flow paths of the heated volatile components from the aerosol-generating material bodies 103 and 303 are axially through the objects 101 and 301 , through the chambers inside the cooling sections 107 and 307 , through the filter sections 109 and 309 , and through the mouth end section 111 , 313 to the user. In one example, the temperature of the heated volatiles generated from the body of the aerosol-generating material is between 60°C and 250°C, which may be higher than acceptable inhalation temperatures for use. As the heated volatiles pass through the cooling sections 107, 307, it will cool and some of the volatiles will condense on the inner surfaces of the cooling sections 107, 307.

In the example of article 301 shown in FIGS. 3 and 4 , cool air will be able to enter cooling section 307 via ventilation holes 317 formed in cooling section 307 . This cool air will mix with the heated volatiles to provide additional cooling to the heated volatiles. Production method

In another aspect, a method of forming an amorphous solid is provided, the amorphous solid comprising: From about 1 to about 12 wt% cannabis constituents, derivatives or extracts; from about 10 to about 80 wt % of the aerosol former material; gelling agent; and optional filler, wherein the total amount of the gelling agent and optional filler is from about 10 to about 60 wt%; The wt% value is calculated on the basis of dry weight; The method contains: (a) providing a slurry comprising cannabis components, derivatives or extracts, gelling agents, aerosol formers, solvents and any optional other components of an amorphous solid; (b) forming a slurry layer; (c) curing the slurry layer; and (d) drying the slurry to form the amorphous solid.

Another aspect of the present invention provides a method of making a consumable or system as previously described. The method includes a method of making the amorphous solid and adding the amorphous solid to the consumable or system. The method may comprise (a) forming a slurry comprising the amorphous solid or precursor components thereof, (b) forming a slurry layer, and (c) solidifying the slurry, (d) drying to form the amorphous solid, and (e) adding the resulting amorphous solid to the consumable or system.

In step (a), a component, derivative or extract of cannabis may first be dissolved in the aerosol former material, after which the resulting solution may be added to the other components of the slurry.

Step (b) of the above method of forming a slurry layer may comprise, for example, spraying, casting or extruding the slurry. In some cases, the layer is formed by electrospraying the slurry. In some cases, the layer is formed by casting the slurry.

In some cases, steps (b) and/or (c) and/or (d) may occur at least partially simultaneously (eg, during electrical sprinkling). In some cases, these steps may occur sequentially.

In some cases, a curing agent (eg, a calcium source) may be added to the slurry before or during step (b). This is appropriate where gelation occurs relatively slowly (eg using an alginate gelling agent), so that the slurry can be cast eg after adding the curing agent.

In other cases, step (c) of setting the slurry may comprise adding a curing agent to the slurry layer. For example, the curing agent can be sprayed onto the slurry, or the curing agent can be preloaded onto the surface of the layered slurry.

For example, a solidifying agent comprising a calcium source (eg, calcium chloride or calcium citrate) can be added to a slurry containing alginate and/or pectin to form a calcium-crosslinked alginate/pectin gel . In some cases where gelling occurs rapidly (such as with pectin gelling agents), calcium should be added after casting (since the slurry is too viscous to cast).

The total amount of curing agents, such as calcium sources, may be 0.5 to 5 wt% (calculated on a dry basis). It has now been found that adding too little curing agent results in the gel not being able to stabilize any optional fragrance and resulting in the fragrance being lost from the gel. It has also been found that adding too much curing agent can result in a very sticky or very brittle gel with poor workability.

Alginates are derivatives of alginic acid, usually high molecular weight polymers (10 to 600 kDa). Alginic acid is a polysaccharide copolymer formed by β-D-mannuronic acid (M) and α-L-glucuronic acid (G) units (blocks) linked together by (1,4)-glycosidic bonds. After the addition of calcium cations, the alginate cross-links to form a gel. Alginates with high G monomer content are more likely to form gels with the addition of a calcium source. Thus, in some cases, the gel precursor may comprise alginate wherein at least about 40%, 45%, 50%, 55%, 60% or 70% of the monomer units in the alginate copolymer are alpha- L-glucuronic acid (G) unit.

In some cases, the slurry may be heated before and during casting. This slows gelation, improves workability and simplifies the casting process. In addition, heating the slurry melts optional fragrance ingredients (eg, menthol) for ease of handling.

In some cases, menthol or other optional flavor can be distributed in the slurry in powder form. In some cases, menthol or other flavors may melt in the slurry (where it is heated). In this case, an emulsifier such as gum arabic may be added to disperse the molten menthol in the slurry.

In some cases, the slurry can be cast onto a ribbon cast. The sheet can be loaded with a release agent, such as lecithin, which can help separate the ribbon cast from the amorphous solid.

In another aspect, a slurry is provided, comprising: From about 1 to about 12 wt% cannabis constituents, derivatives or extracts; from about 10 to about 80 wt % of the aerosol former material; gelling agent; and optional filler, wherein the total amount of the gelling agent and optional filler is from about 10 to about 60 wt%; where the wt% value is calculated on a dry basis; and solvent.

In some embodiments, the slurry solvent comprises or is one or more of water, ethanol, methanol, dimethylsulfite, acetone, hexane, and toluene.

In certain embodiments, the slurry solvent may comprise water. In some cases, the slurry solvent may consist essentially of or consist of water.

In some cases, the slurry may comprise about 50 wt%, 60 wt%, 70 wt%, 80 wt%, or 90 wt% solvent (WWB).

In some examples, the viscosity of the slurry at 46.5°C is from about 1 to about 20 Pa·s, eg, about 10 to about 20 Pa·s at 46.5°C, eg, about 14 to about 20 Pa·s at 46.5°C About 16 Pa·s.

The discussion herein regarding amorphous solids is explicitly disclosed in connection with any slurry aspect of the present invention. Compositions for Oral Delivery of Cannabis Components, Derivatives or Extracts

Also provided is a composition for oral delivery of a cannabis component, derivative or extract comprising an amorphous solid comprising: From about 1 to about 12 wt% cannabis constituents, derivatives or extracts; from about 10 to about 80 wt % of the aerosol former material; gelling agent; and optional filler, wherein the total amount of the gelling agent and optional filler is from about 10 to about 60 wt%; The wt% value is calculated on the basis of dry weight.

In some embodiments, the composition for oral delivery may be provided in the form of a chewable, dissolvable stick, lozenge, chewing gum, snuff, or moist snuff.

In some embodiments, the composition for oral delivery further comprises one or more additives selected from the group consisting of sweeteners, taste modifiers, salts, buffers, colorants, oral care additives, preservatives, disintegration aids agents, emulsifiers, preservatives and antioxidants.

The aerosol former materials discussed above can be used as humectants in oral delivery compositions. Disclosures above with respect to amorphous solids for aerosol generation (e.g. with respect to constituents, derivatives or extracts of cannabis, gelling agents, aerosol former materials [humectants], optional fillers, other optional Selective ingredients such as additional actives, fragrances and other functional materials) are equally applicable to this aspect of the invention.

For example, the humectant may comprise a humectant selected from the group consisting of glycerol, propylene glycol, diethylene glycol, triethylene glycol, tetraethylene glycol, 1,3-butanediol, butane erythritol, meso-butane erythritol, vanilla Ethyl acetate, ethyl laurate, diethyl suberate, triethyl citrate, triacetin, diacetin mixture, benzyl benzoate, benzyl phenylacetate, tributyrin, One or more compounds of lauryl acetate, lauric acid, myristic acid and propylene carbonate.

In some embodiments, the humectant may include one or more of butane erythritol, propylene glycol, glycerol, and triacetin. In some cases, the humectant comprises, consists essentially of, or consists of glycerol, optionally in combination with propylene glycol.

Suitably, the amorphous solid may comprise from about 10 wt% to about 80 wt% humectant (calculated on a dry weight basis), for example from about 20 to 80 wt%, or from 30 wt% or 40 wt% to about 80 wt% %, 75 wt% or 60 wt%.

Compositions for oral delivery may comprise about 10 to 100 wt% amorphous solids, or about 20 wt%, about 30 wt%, about 40 wt%, about 50 wt% to about 60 wt%, about 70 wt% %, about 80 wt % or about 90 wt % of amorphous solids. For example, in some embodiments, the composition for oral delivery may comprise about 10 to 60 wt%, eg, about 15 to 50 wt%, of amorphous solids. These wt% values are calculated on a wet weight (WWB) basis, ie including any water or other solvents present in the amorphous solid. example

Amorphous solids (AS) were prepared according to the following method.

A solution of gelling agent (CMC or alginate) and 30 mg/ml cannabidiol (CBD) in a 55:45 w/w mixture of propylene glycol (PG) and glycerol (VG) with distilled water in a high shear mixer Mix until a free-flowing slurry forms. The slurry is cast and dried to form the amorphous solid.

The amorphous solid is formed from a slurry comprising: water CMC Alginate 30 mg/ml CBD in PG/VG solution AS1 1000ml 20g 80g AS2 550ml 30 g 80g Exemplary embodiment

1. An amorphous solid or slurry as defined in the Summary of the Invention comprising about 1-12 wt% of a hemp component, derivative or extract.

2. The amorphous solid or slurry as described in Example 1, comprising about 1-10 wt% of a cannabis component, derivative or extract.

3. The amorphous solid or slurry as described in Example 2, comprising about 1-8 wt% of a cannabis component, derivative or extract.

4. The amorphous solid or slurry as described in Example 3, comprising about 1-7 wt% of a cannabis component, derivative or extract.

5. The amorphous solid or slurry of Example 4, comprising about 1-6 wt % of a cannabis component, derivative or extract.

6. The amorphous solid or slurry of Example 1, comprising about 1.5-12 wt% of a cannabis component, derivative or extract.

7. The amorphous solid or slurry of Example 6, comprising about 1.5-10 wt% of a cannabis component, derivative or extract.

8. The amorphous solid or slurry of Example 7, comprising about 1.5-8 wt% of a cannabis component, derivative or extract.

9. The amorphous solid or slurry of Example 8, comprising about 1.5-7 wt% of a cannabis component, derivative or extract.

10. The amorphous solid or slurry of Example 9, comprising about 1.5-6 wt% of a cannabis component, derivative or extract.

11. The amorphous solid or slurry of Example 1, comprising about 2-12 wt% of a cannabis component, derivative or extract.

12. The amorphous solid or slurry of Example 11 comprising about 2-10 wt% of a cannabis component, derivative or extract.

13. The amorphous solid or slurry of Example 12, comprising about 2-8 wt% of a cannabis component, derivative or extract.

14. The amorphous solid or slurry of Example 13 comprising about 2-7 wt% of a cannabis component, derivative or extract.

15. The amorphous solid or slurry of Example 14, comprising about 2-6 wt% of a cannabis component, derivative or extract.

16. The amorphous solid or slurry of any preceding embodiment, wherein the cannabis composition, derivative or extract comprises or is one or more compounds selected from the group consisting of cannabinoids, terpenes, alkaloids and flavonoids.

17. The amorphous solid or slurry of any preceding embodiment, wherein the cannabis component, derivative or extract comprises or is one or more compounds selected from the group consisting of cannabinoids or terpenes.

18. The amorphous solid or slurry of any preceding embodiment, wherein the component, derivative or extract of cannabis comprises or is one or more cannabinoids.

19. The amorphous solid or slurry of any one of embodiments 16 to 18, wherein the terpene is a triterpene.

20. The amorphous solid or slurry of any one of embodiments 16 to 19, wherein the cannabinoid is a phytocannabinoid.

21. The amorphous solid or slurry of embodiments 16 to 20, wherein the cannabinoid is selected from cannabigerol (CBG), cannabichromene (CBC), cannabidiol (cannabidiol) (CBD), tetrahydrocannabinol (THC), cannabinol (CBN), cannabinodiol (CBDL), cannabicyclol (CBL), hypocannabinoids (cannabivarin) (CBV), tetrahydrocannabivarin (THCV), cannabivarin (CBDV), cannabichromevarin (CBCV), cannabigerovarin (CBGV), cannabis cannabigerol monomethyl ether (CBGM), cannabinerolic acid, cannabidivarin (CBDA), cannabinol propyl variant (CBNV), cannabinoid three Cannabitriol (CBO), tetrahydrocannabmolic acid (THCA) and/or tetrahydrocannabivarinic acid (THCV A).

22. The amorphous solid or slurry of embodiment 21, wherein the cannabinoid is selected from cannabidiol (CBD) and/or THC.

23. The amorphous solid or slurry of embodiment 22, wherein the cannabinoid is CBD.

24. The amorphous solid or slurry of embodiment 22, wherein the cannabinoid is THC.

25. The amorphous solid or slurry of any preceding embodiment, comprising about 10 to 50 wt% gelling agent.

26. The amorphous solid or slurry of embodiment 25, comprising about 10-45 wt% gelling agent.

27. The amorphous solid or slurry of embodiment 26, comprising about 10-40 wt% gelling agent.

28. The amorphous solid or slurry of embodiment 27, comprising about 10-35 wt% gelling agent.

29. The amorphous solid or slurry of embodiment 28, comprising about 10-30 wt% gelling agent.

30. The amorphous solid or slurry of any one of embodiments 1-24, comprising about 15-65 wt% gelling agent.

31. The amorphous solid or slurry of any one of embodiments 1-24, comprising about 15-60 wt% gelling agent.

32. The amorphous solid or slurry of embodiment 31, comprising about 15-50 wt% gelling agent.

33. The amorphous solid or slurry of embodiment 32, comprising about 15-45 wt% gelling agent.

34. The amorphous solid or slurry of embodiment 33, comprising about 15-40 wt% gelling agent.

35. The amorphous solid or slurry of embodiment 34, comprising about 15-35 wt% gelling agent.

36. The amorphous solid or slurry of embodiment 35, comprising about 15-30 wt% gelling agent.

37. The amorphous solid or slurry of any one of embodiments 1-24, comprising about 20-60 wt% gelling agent.

38. The amorphous solid or slurry of embodiment 37, comprising about 20-50 wt% gelling agent.

39. The amorphous solid or slurry of embodiment 38, comprising about 20-45 wt% gelling agent.

40. The amorphous solid or slurry of embodiment 39, comprising about 20-40 wt% gelling agent.

41. The amorphous solid or slurry of embodiment 40, comprising about 20-35 wt% gelling agent.

42. The amorphous solid or slurry of embodiment 41, comprising about 20-30 wt% gelling agent.

43. The amorphous solid or slurry of any preceding embodiment, comprising about 1-50 wt% filler.

44. The amorphous solid or slurry of embodiment 43, comprising about 5-40 wt% filler.

45. The amorphous solid or slurry of embodiment 44, comprising about 10-20 wt% filler.

46. The amorphous solid or slurry of any one of embodiments 1 to 42, comprising less than 20 wt% filler.

47. The amorphous solid or slurry of any one of embodiments 1 to 42, comprising less than 10 wt% filler.

48. The amorphous solid or slurry of any one of embodiments 1 to 42, comprising less than 5 wt% filler.

49. The amorphous solid or slurry of any one of embodiments 1 to 42, excluding fillers.

50. The amorphous solid or slurry of any preceding embodiment, comprising about 10-75 wt% aerosol former material/humectant.

51. The amorphous solid or slurry of embodiment 50, comprising about 10-60 wt% aerosol former material/humectant.

52. The amorphous solid or slurry of Example 51, comprising about 10-50 wt% aerosol former material/humectant.

53. The amorphous solid or slurry of any one of embodiments 1-49, comprising about 20-80 wt% aerosol former material/humectant.

54. The amorphous solid or slurry of embodiment 53, comprising about 20-75 wt% aerosol former material/humectant.

55. The amorphous solid or slurry of embodiment 54, comprising about 20-60 wt% aerosol former material/humectant.

56. The amorphous solid or slurry of embodiment 55, comprising about 20-50 wt% aerosol former material/humectant.

57. The amorphous solid or slurry of any one of embodiments 1-49, comprising about 30-80 wt% aerosol former material/humectant.

58. The amorphous solid or slurry of embodiment 57, comprising about 30-75 wt% aerosol former material/humectant.

59. The amorphous solid or slurry of embodiment 58, comprising about 30-60 wt% aerosol former material/humectant.

60. The amorphous solid or slurry of Example 59, comprising about 30-50 wt% aerosol former material/humectant.

61. The amorphous solid or slurry of any one of embodiments 1-49, comprising about 40-80 wt% aerosol former material/humectant.

62. The amorphous solid or slurry of Example 61, comprising about 40-75 wt% aerosol former material/humectant.

63. The amorphous solid or slurry of embodiment 62, comprising about 40-60 wt% aerosol former material/humectant.

64. The amorphous solid or slurry of embodiment 63, comprising about 40-50 wt% aerosol former material/humectant.

65. The amorphous solid or slurry of any one of embodiments 1-49, comprising about 50-80 wt% aerosol former material/humectant.

66. The amorphous solid or slurry of embodiment 65, comprising about 60 to 80 wt% aerosol former material/humectant.

67. The amorphous solid or slurry of embodiment 66, comprising about 70 to 80 wt% aerosol former material/humectant.

68. The amorphous solid or slurry of any one of embodiments 1-49, comprising about 30-40 wt% aerosol former material/humectant.

69. The amorphous solid or slurry of any preceding embodiment, wherein the aerosol former material/humectant comprises (or is) glycerol, propylene glycol, diethylene glycol, triethylene glycol, tetraethylene glycol Ethylene glycol, 1,3-butanediol, butane erythritol, meso-butane erythritol, ethyl vanillate, ethyl laurate, diethyl suberate, triethyl citrate, triacetin one or more of esters, diacetin mixture, benzyl benzoate, benzyl phenylacetate, tributyrin, lauryl acetate, lauric acid, myristic acid, and propylene carbonate.

70 The amorphous solid or slurry of embodiment 69, wherein the aerosol former material/humectant comprises (or is) butane erythritol, propylene glycol, glycerol and triacetin.

71. The amorphous solid or slurry of embodiment 69 or 70, wherein the aerosol former material/humectant comprises (or is) glycerol or a combination of glycerol and propylene glycol.

72. The amorphous solid or slurry of embodiment 71, wherein the aerosol former material comprises a mixture of glycerol and propylene glycol in a weight ratio of glycerol to propylene glycol of about 3:1 to 1:3.

73. The amorphous solid or slurry of embodiment 72, wherein the aerosol former material comprises a mixture of glycerol and propylene glycol in a weight ratio of about 2:1 to 1:2.

74. The amorphous solid or slurry of embodiment 73, wherein the aerosol former material comprises a mixture of glycerol and propylene glycol in a weight ratio of glycerol to propylene glycol of about 1.5:1 to 1:1.5.

75. The amorphous solid or slurry of embodiment 74, wherein the aerosol former material comprises a mixture of glycerol and propylene glycol in a weight ratio of glycerol to propylene glycol of about 55:45 to 45:55.

76. The amorphous solid or slurry of embodiment 75, wherein the aerosol former material comprises a mixture of glycerol and propylene glycol in a weight ratio of glycerol to propylene glycol of about 45:55.

77. The amorphous solid or slurry of any preceding embodiment, wherein the gelling agent comprises a hydrocolloid.

78. The amorphous solid or slurry of any preceding embodiment, wherein the gelling agent comprises or is selected from polysaccharide gelling agents such as alginate, pectin, starch or derivatives thereof cellulose, cellulose or its derivatives, pullulan, carrageenan, agar and agarose; gelatin; gums such as xanthan, guar and acacia; silica or polysiloxanes such as PDMS and sodium silicate; clays, such as kaolin; and one or more compounds of polyvinyl alcohol.

79. The amorphous solid or slurry of any preceding embodiment, wherein the gelling agent comprises one or more polysaccharide gelling agents.

80. The amorphous solid or slurry of any preceding embodiment, wherein the gelling agent comprises one or more polysaccharide gelling agents.

81. The amorphous solid or slurry as described in any one of embodiments 78 to 80, wherein the polysaccharide gelling agent is selected from: alginate, pectin, starch or derivatives thereof, cellulose or derivatives thereof thing.

82. The amorphous solid or slurry of embodiment 81, wherein the polysaccharide gelling agent is selected from the group consisting of: alginates and cellulose derivatives.

83. The amorphous solid or slurry of embodiment 82, wherein the polysaccharide gelling agent is a cellulose derivative.

84. The amorphous solid or slurry of any one of embodiments 78 to 83, wherein the cellulose or a derivative thereof, or wherein the cellulose derivative is selected from the group consisting of hydroxymethyl cellulose, hydroxyethyl Cellulose, hydroxypropyl cellulose, carboxymethyl cellulose (CMC), hydroxypropyl methyl cellulose (HPMC), methyl cellulose, ethyl cellulose, cellulose acetate (CA), cellulose acetate butyrate cellulose (CAB), and cellulose acetate propionate (CAP).

85. The amorphous solid or slurry of embodiment 84, wherein the cellulose or derivative or cellulose derivative is CMC.

86. The amorphous solid or slurry of embodiment 85, wherein CMC is the only gelling agent present in the amorphous solid.

87. The amorphous solid or slurry of embodiment 82, wherein the polysaccharide gelling agent is an alginate.

88. The amorphous solid or slurry of embodiment 87, wherein the alginate is the only gelling agent present in the amorphous solid.

89. The amorphous solid or slurry of embodiment 78, wherein the gelling agent comprises (or is) alginate, pectin, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose one or more of vegan, amylopectin, xanthan gum, guar gum, carrageenan, agarose, gum arabic, calcined silica, PDMS, sodium silicate, kaolin and polyvinyl alcohol.

90. The amorphous solid or slurry of embodiment 78, wherein the gelling agent comprises (or is) hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose, guar gum, acacia One or more of gum, alginate and/or pectin.

91. The amorphous solid or slurry of any one of embodiments 78 to 82, 84, 85, or 87 to 90, wherein the alginate is sodium alginate.

92. The amorphous solid or slurry of any preceding embodiment, wherein the gelling agent is not cross-linked.

93. The amorphous solid or slurry of any one of embodiments 43 to 48, wherein the filler is selected from inorganic filler materials, wood pulp; tobacco pulp; hemp fiber; starch and starch derivatives, such as maltose paste Essence; Chitosan; Cellulose and Cellulose Derivatives.

94. The amorphous solid or slurry of embodiment 93, wherein the filler is wood pulp.

95. The amorphous solid or slurry of any preceding embodiment, wherein the amorphous solid or slurry does not contain calcium carbonate, such as chalk.

96. The amorphous solid or slurry of any preceding embodiment, wherein the amorphous solid or slurry does not comprise tobacco fibers.

97. The amorphous solid as in any preceding embodiment, wherein the amorphous solid consists or consists essentially of a gelling agent, a solvent such as water, an aerosol former material, a component of cannabis, a derivative or Extracts, and optional flavors and/or optional additional actives and/or optional fillers.

98. The amorphous solid of any preceding embodiment, wherein the amorphous solid consists or consists essentially of a gelling agent, a solvent such as water, an aerosol-forming agent material, a component of cannabis, a derivative or Extract composition.

99. An aerosol-generating material comprising the amorphous solid of any preceding embodiment.

100. The aerosol-generating material of embodiment 99, wherein the aerosol-generating material does not comprise tobacco fibers.

101. The aerosol-generating material of any one of embodiments 99 to 100, comprising about 50-100 wt% (WWB) of the amorphous solid.

102. The aerosol-generating material of embodiment 101, comprising about 50-95 wt% (WWB) of the amorphous solid.

103. The aerosol-generating material of embodiment 102, comprising about 50-90 wt% (WWB) of the amorphous solid.

104. The aerosol-generating material of any one of embodiments 99 to 100, comprising about 60-100 wt% (WWB) of the amorphous solid.

105. The aerosol-generating material of embodiment 104, comprising about 60-95 wt% (WWB) of the amorphous solid.

106. The aerosol-generating material of embodiment 105, comprising about 60-90 wt% (WWB) of the amorphous solid.

107. The aerosol-generating material of any one of embodiments 99 to 100, comprising about 70-100 wt% (WWB) of the amorphous solid.

108. The aerosol-generating material of embodiment 107, comprising about 70-95 wt% (WWB) of the amorphous solid.

109. The aerosol-generating material of embodiment 108, comprising about 70-90 wt% (WWB) of the amorphous solid.

110. The aerosol-generating material of any one of embodiments 99 to 100, consisting of or consisting essentially of the amorphous solid.

111. A consumable for a non-flammable aerosol supply device, the consumable comprising the aerosol-generating material of any one of embodiments 99 to 110.

112. A non-flammable aerosol supply system comprising the consumable as described in embodiment 111 and a non-flammable aerosol supply device.

113. A consumable for use in the non-combustible aerosol supply device of embodiment 111 or the non-combustible aerosol supply system of embodiment 112, wherein the non-combustible aerosol supply device is a heat-not-burn device .

114. A consumable for use in the non-flammable aerosol supply device of embodiment 111 or the non-flammable aerosol supply system of embodiment 112, wherein the non-flammable aerosol supply device is an electronic cigarette mixing device .

115. A method of forming an amorphous solid as defined in any one of embodiments 1 to 98, the method comprising: (a) providing a slurry comprising the hemp component, derivative or extract, gelling agent, aerosol former material, solvent and any optional other components of the amorphous solid; (b) forming a slurry layer; (c) curing the slurry layer; and (d) drying the slurry to form the amorphous solid.

116. The method of embodiment 115 or the slurry of any one of embodiments 1 to 96, wherein the solvent comprises water.

117. The method of embodiment 115 or the slurry of any one of embodiments 1 to 96, wherein the solvent consists essentially of or consists of water.

118. The method of embodiments 115 to 117 or the slurry of any one of embodiments 1 to 96, 116 or 117, wherein the slurry comprises about 50 wt%, 60 wt%, 70 wt% , 80 wt% or 90 wt% of solvent (WWB).

The amorphous solid used in the composition of the fifth aspect as defined in the Summary of the Invention (ie, in the composition for oral delivery) may be a non-crystalline solid as defined in any of the preceding embodiments crystalline solid. definition

The aerosol-generating materials described herein comprise "amorphous solids," which are alternatively referred to as "monolithic solids" (ie, non-fibrous), or "xerogels." The amorphous solid is a solid material that retains some fluid, such as a liquid, in it.

As used herein, the term "tobacco material" refers to any material comprising tobacco or a derivative thereof. The term "tobacco material" may include one or more of tobacco, tobacco derivatives, expanded tobacco, reconstituted tobacco, or tobacco substitutes. The tobacco material may comprise one or more of ground tobacco, tobacco fibers, shredded tobacco, extruded tobacco, tobacco stems, reconstituted tobacco, and/or tobacco extracts.

The tobacco used to produce the tobacco material can be any suitable tobacco, such as single grade or blend, cut or whole lamina, including Virginia and/or Burley and/or Oriental. It may also be "fines" or dust of tobacco particles, puffed tobacco, tobacco stems, puffed tobacco stems and other processed tobacco stem material, such as shredded rolled tobacco stems. The tobacco material may be ground tobacco or reconstituted tobacco material. The reconstituted tobacco material may comprise tobacco fibers, and may be formed by casting, by Fourdrinier-type paper-based methods in which tobacco extract is added back, and by extrusion.

All weight percentages (expressed as wt %) stated herein are calculated on a dry weight basis (DWB) unless expressly stated otherwise. All weight ratios are also calculated on a dry basis. Weight calculated on a dry weight basis refers to the whole extract or slurry or material excluding water or other solvents, and may include ingredients that are inherently liquid at room temperature and pressure, such as glycerin. Conversely, weight percentages stated on a wet weight basis (WWB) refer to all ingredients, including water or other solvents.

For the avoidance of doubt, where the term "comprising" is used in this specification to define the invention or features of the invention, it is also disclosed that the term "consisting essentially of" or "consisting of" may be used in place of "comprising" ” to define an embodiment of the invention or feature. Reference to a material that "comprises" certain features means that those features are included, contained in, or retained within the material.

The above-described embodiments are to be understood as illustrative examples of the invention. It should be understood that any feature described in relation to any embodiment can be used alone or in combination with other features described and also in combination with one or more features of any other embodiment or in any combination. Furthermore, equivalents and modifications not described above may also be employed without departing from the scope of the invention as defined by the appended claims.

The various embodiments described herein are provided only to assist in understanding and revealing the claimed features. These embodiments are merely representative examples of embodiments, and are not exhaustive and/or exclusive. It should be understood that the advantages, embodiments, examples, functions, features, structures and/or other aspects described herein should not be construed as being equivalent to the scope of the invention as defined by the claims or equivalents to the claims the limitations of the present invention, and other embodiments may be utilized and modifications may be made without departing from the scope of the claimed invention. Various embodiments of the invention may suitably comprise, consist of, or consist essentially of any suitable combination of the disclosed elements, components, features, parts, steps, means, etc., except as specifically described herein. Furthermore, the present disclosure may include other inventions that are not presently claimed but may be claimed in the future.

11: Sleeve 17: Top plate 19: Bottom plate 20: insertion point; opening 23: Heater device 25: Control circuit 27: Energy 31: insulator; vacuum sleeve 33: Collar 35: Chamber 35f: Cooling structure 36: Air Gap 51: Device 53: Mouth or Proximal 55: Remote 57: On/Off button 59: Shell 60: Ridge 101: consumables; objects 103: Main body of aerosol generating material 105: Filter Assembly 107: Cooling section 109: Filter segment 111: Mouth end segment 113: First End 115: Second End 301: Object 307: Cooling section 313: Proximal 315: Remote 317: Ventilation Area; Ventilation Holes

Figure 1 shows a cross-sectional view of an example of a consumable product.

FIG. 2 shows a perspective view of the consumable of FIG. 1 .

Figure 3 shows a cross-sectional elevation view of an example of a consumable product.

FIG. 4 shows a perspective view of the consumable of FIG. 3 .

Figure 5 shows a perspective view of an example of a non-flammable aerosol supply system.

Figure 6 shows a cross-sectional view of an example of a non-flammable aerosol supply system.

Figure 7 shows a perspective view of an example of a non-flammable aerosol supply system.

101: consumables; objects

103: Main body of aerosol generating material

105: Filter Assembly

107: Cooling section

109: Filter segment

111: Mouth end segment

113: First End

115: Second End

Claims (25)

An amorphous solid for generating an aerosol, the amorphous solid comprising: From about 1 to about 12 wt% cannabis constituents, derivatives or extracts; from about 10 to about 80 wt % of the aerosol former material; gelling agent; and optional filler, wherein the total amount of the gelling agent and optional filler is from about 10 to about 60 wt%; The wt% value is calculated based on dry weight. The amorphous solid of claim 1 comprising from about 2 to about 8 wt % of a cannabis component, derivative or extract. The amorphous solid of claim 1 or claim 2, comprising from about 60 to about 80 wt% aerosol former material. The amorphous solid of any one of claims 1 to 3, comprising from about 15 to about 40 wt % of a gelling agent. The amorphous solid according to any one of claims 1 to 4, wherein the gelling agent comprises or is selected from polysaccharide gelling agents, such as alginate, pectin, starch or its derivatives, cellulose or derivatives thereof, pullulan, carrageenan, agar and agarose; gelatin; gums such as xanthan, guar and acacia; silica or polysiloxanes such as PDMS and sodium silicate ; clay, such as kaolin; and one or more compounds of polyvinyl alcohol. The amorphous solid according to claim 5, wherein the polysaccharide gelling agent is selected from alginates and cellulose derivatives. The amorphous solid of claims 5 to 7, wherein the cellulose derivative is selected from the group consisting of hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose (CMC), hydroxypropyl cellulose methyl cellulose (HPMC), methyl cellulose, ethyl cellulose, cellulose acetate (CA), cellulose acetate butyrate (CAB), and cellulose acetate propionate (CAP). The amorphous solid of any one of claims 1 to 7, wherein the gelling agent is not cross-linked. The amorphous solid of any one of claims 1 to 8, wherein the gelling agent is CMC. The amorphous solid of any one of claims 1 to 9, wherein the aerosol former material comprises (or is) glycerol, propylene glycol, diethylene glycol, triethylene glycol, tetraethylene glycol, 1,3 -Butanediol, butane erythritol, meso-erythritol, ethyl vanillate, ethyl laurate, diethyl suberate, triethyl citrate, glyceryl triacetate, One or more of a mixture of diacetin, benzyl benzoate, benzyl phenylacetate, tributyrin, lauryl acetate, lauric acid, myristic acid, and propylene carbonate. The amorphous solid of any one of claims 1 to 10, wherein the aerosol former material comprises or is glycerol or a combination of glycerol and propylene glycol. The amorphous solid of any one of claims 1 to 11, wherein the component, derivative or extract of cannabis is a cannabinoid. The amorphous solid of claim 12, wherein the cannabinoid is selected from the group consisting of cannabigerol (CBG), cannabichromene (CBC), cannabidiol (CBD), tetrahydro Tetrahydrocannabinol (THC), Cannabinol (CBN), Cannabinodiol (CBDL), Cannabicyclol (CBL), Cannabivarin (CBV), Subtetra Tetrahydrocannabivarin (THCV), Cannabidivarin (CBDV), Cannabichromevarin (CBCV), Cannabigerovarin (CBGV), Cannabigerol monomethyl ether ) (CBGM), cannabinerolic acid, cannabidivarin (CBDA), cannabinol propyl variant (CBNV), cannabitriol (CBO), four tetrahydrocannabmolic acid (THCA) and tetrahydrocannabivarinic acid (THCV A). The amorphous solid of claim 13, wherein the cannabinoid is cannabidiol. An aerosol-generating material comprising the amorphous solid of any one of claims 1 to 14. The aerosol-generating material of claim 15, comprising about 50 to 100 wt% (WWB) of the amorphous solid. A consumable for a non-flammable aerosol supply device, the consumable comprising an aerosol generating material as claimed in claim 15 or claim 16. A non-combustible aerosol supply system comprising the consumable as claimed in claim 17 and a non-combustible aerosol supply device. A composition for oral delivery of a component, derivative or extract of cannabis, the composition comprising an amorphous solid comprising: From about 1 to about 12 wt% cannabis constituents, derivatives or extracts; from about 10 to about 80 wt% of a humectant; gelling agent; and optional filler, wherein the total amount of the gelling agent and optional filler is from about 10 to about 60 wt%; The wt% value is calculated on a dry weight basis. The composition for oral delivery of claim 19, wherein the cannabis component, derivative or extract is a cannabinoid. The composition for oral delivery of claim 20, wherein the cannabinoid is selected from cannabigerol (CBG), cannabichromene (CBC), cannabidiol (CBD) , Tetrahydrocannabinol (THC), Cannabinol (CBN), Cannabinodiol (CBDL), Cannabicyclol (CBL), Cannabivarin (CBV) , tetrahydrocannabivarin (THCV), cannabis dipeptide (cannabidivarin) (CBDV), cannabichromevarin (CBCV), cannabigerovarin (CBGV), cannabinol monomethyl ether ( cannabigerol monomethyl ether) (CBGM), cannabinerolic acid, cannabidivarin (CBDA), cannabinol propyl variant (CBNV), cannabitriol (CBO) ), tetrahydrocannabmolic acid (THCA), and tetrahydrocannabivarinic acid (THCV A). The composition for oral delivery of claim 20, wherein the cannabinoid is cannabidiol. A method of forming an amorphous solid as claimed in any one of claims 1 to 14 or a composition as claimed in any one of claims 19 to 22, the method comprising: (a) provide a slurry comprising a component, derivative or extract of cannabis, a gelling agent, an aerosol-forming material or wetting agent, a solvent and any optional other components of an amorphous solid; (b) forming a slurry layer; (c) setting the slurry layer; and (d) drying the slurry to form the amorphous solid. A slurry containing: From about 1 to about 12 wt% cannabis constituents, derivatives or extracts; from about 10 to about 80 wt% of an aerosol former material or humectant; gelling agent; and optional filler, wherein the total amount of the gelling agent and optional filler is from about 10 to about 60 wt%; where the wt% value is calculated on a dry basis; and a solvent. The method of claim 23 or the slurry of claim 24, wherein the solvent comprises water.

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