TW202208850A - Screening test paper reading system that includes a reading illumination unit, a screening test paper, an optical analysis unit, a test paper carrier unit, a displacement carrying platform unit, and a circuit board unit - Google Patents

Abstract

A screening test paper reading system comprises: a reading illumination unit that includes a reading device and an illumination device; a screening test paper on which a reaction zone is arranged, the reaction zone being operable to generate a chemical reaction with respect to certain specific specimens and to alter a color of an inspection line of the reaction zone; an optical analysis unit that is connected with the reading illumination unit to analyze a spectrum signal of an image of the inspection line of the screening test paper reaction zone received by the reading device; a test paper carrier unit, on which a carrying zone is arranged for receiving the screening test paper and making the screening test paper fixed on the test paper carrier unit, the test paper carrier unit being further provided with a transmission section; a displacement carrying platform unit, which comprises a displacement platform and a driving device and a carrying base, the carrying base being for carrying the reading illumination unit, the test paper carrier unit, and the displacement platform, and the driving device, and also making the driving device coupled to the transmission section; and a circuit board unit, which is electrically connected among the reading illumination unit, the optical analysis unit, and the displacement carrying platform unit to provide processing to circuit signals of each of the abovementioned units; wherein the test paper carrier unit is connected to and disposed on the displacement platform, and when the screening test paper is introduced into the carrying zone of the test paper carrier unit, the driving device is activated and causes, by means of the transmission section, the displacement carrying platform unit to move, and when the test carrier unit is moved to a reading position of the reading illumination unit, the illumination device emits light to irradiate the screening test paper. The reading device proceeds with reading of the spectrum signal of a reflected image of the inspection line of the reaction zone that is irradiated by the emitted light, followed by transmission to the optical analysis unit to carry out operation and analysis of the spectrum signal of the reflected image.

Description

Screening test strip reading system

The present invention relates to a screening test paper reading system, especially a screening test paper reading system that can achieve rapid screening of new coronary pneumonia test strips and rapid repeated screening.

Press, as human beings pay more and more attention to the screening of their own physical health, including physiological screening or environmental screening, it has become a very hot topic. FIG. 1 is a schematic diagram of a conventional screening test paper. As shown in the figure, the screening test paper 80 is provided with a reaction area 81 . When the user drops the sample on the reaction area 81 , the reaction area 81 will chemically react with the sample, so that the color of the reaction area 81 changes. The user can judge whether the specimen is normal or not according to the color change and contrasting color of the reaction area. However, the accuracy of recognizing color changes through the human eye is very poor, which may lead to misjudgment or false negatives. For example, the recent impact of the new crown pneumonia epidemic has greatly affected the world's economy, transportation and life. Therefore, governments and research institutions of various countries and Manufacturers are actively developing technologies that can be used for rapid screening to diagnose the epidemic. For example, using rapid screening test strips for mass and rapid testing, and then re-testing or re-confirmation for precise screening during the testing process if necessary, most of them use Spectral analyzer for detailed inspection.

Known Taiwan Patent I612306 "Portable Rapid Screening In Vitro Detection System "System", an in vitro detection system for portable rapid screening, including an in vitro detector and an electronic device, the in vitro detector is a closed environment, and a sample box is installed inside to accommodate a post-test rapid detection system. Screening test paper, a photographing image processor for capturing a display image of the tested quick-screening test paper in the sample box, and a transmission interface control processor for transmitting the display image to the electronic device, through The electronic device has an analysis software to compare with a data parameter downloaded from the cloud of an invention, so as to generate a test report of the subject's physiological response and the degree of physiological response, so as to achieve early detection, early prevention and planning. The function of the former case uses image recognition technology for detection, which may still cause the system to become false negatives because the system cannot judge the image of the screening test paper. And the spectral signal measurement in this case is more accurate.

A known Chinese mainland patent CN104020286 "An immunochromatographic test strip quantitative detector and detection method", an immunochromatographic quantitative detector and detection method for colloidal gold, latex, etc. used in the quantitative detection of immunochromatographic test strips. Drop the sample to be tested on the lateral immunochromatography test strip pre-marked and coated with the corresponding antigen and antibody, and then insert the test strip into the detection tank of the immunochromatographic quantitative detector, and the immunochromatographic quantitative detector passes through. Multi-wavelength scanning confirms the color chromaticity and background chromaticity of the C and T line regions on the nitrocellulose membrane of the test strip. According to the built-in algorithm of the instrument, the optical density values of the quality control zone and detection zone are identified, calculated and analyzed. Obtain the concentration of positive markers contained in the sample to be tested, print and report and store the result value. The previous case used multi-wavelength scanning multi-wavelength scanning color chromaticity and background chromaticity, and The spectral signal measurement using the spectrometer is still different from the technique in this case, and the spectral signal measurement in this case is relatively accurate.

However, when using the spectrum analyzer for screening, the user should avoid manually placing the screening test paper in the corresponding position for the spectrum analyzer to capture the color signal of the reaction area, which may easily lead to inaccurate placement. The predicament of being unable to capture, wastes a lot of time in adjusting the position of the screening test paper, and if the color development of the screening test paper is not complete, it may lead to misjudgment results, so it is difficult to be regarded as practical, and the invention in this case uses another kind of screening test paper The reading system includes a reading lighting unit, has a reading device and a lighting device, and utilizes an optical analysis unit, which is connected to the reading lighting unit for analyzing the screening test paper reaction received by the reading device The spectral signal of the detection line image in the area is used to accurately measure the analyte reaction of the screening test paper.

One of the objectives of the present invention is to disclose a screening test paper reading system, so as to achieve the effects of rapid screening and repeated screening test paper.

One of the objectives of the present invention is to disclose a screening test paper reading system, which uses an imaging amplifying device for providing a reflected image spectral signal for amplifying the detection line of the reaction area irradiated by the emission light source, for use in Accurately measure the spectral signal of the analyte in the screening test paper.

According to the present invention, a screening test paper reading system is disclosed, comprising: a reading light unit, which has a reading device and a light device; a screening test paper, on which is configured a reaction area, the reaction area can The specimen produces a chemical reaction response, and change the color of the detection line of the reaction area; an optical analysis unit, connected to the reading light unit, for analyzing the spectral signal of the detection line image of the screening test paper reaction area received by the reading device; a test paper carrier unit, which is provided with a bearing area for accommodating the screening test paper and fixing the screening test paper on the test paper carrier unit, and the test paper carrier unit is further provided with a linkage part; A displacement riding platform unit, which has a displacement platform, a driving device and a loading base, the loading base is used for riding the reading light unit, the test strip loading platform unit, the displacement platform and the driving device, and in addition The driving device is operatively connected with the linkage part; and a circuit board unit is electrically connected between the reading and lighting unit, the optical analysis unit and the displacement riding platform unit to provide circuit signal processing of the above-mentioned units ; Wherein, the test paper carrier unit is connected and placed on the displacement platform, and when the screening test paper is placed in the bearing area of the test paper carrier unit, the driving device will be activated and make the displacement through the linkage part The loading platform unit moves, and when the test paper carrier unit moves to the reading position of the reading illumination unit, the illumination device will emit a light source to illuminate the screening test paper, and the reading device will read and pass the emitted light. The detection line irradiated by the light source in the reaction area reflects the spectral signal of the image, which is subsequently sent to the optical analysis unit for calculation and analysis of the spectral signal of the reflected image.

As in the above screening test paper reading system, wherein the displacement riding platform unit further includes a position sensor for sensing the relative position of the displacement riding platform unit.

According to the application for the above screening test strip reading system, wherein the driving device is a stepper motor.

As in the above screening test strip reading system, wherein the linkage part is a rack.

The screening test strip reading system as described above, wherein the specific sample application of the screening test strip is saliva, urine, blood plague, water, food, toxic and harmful substances or microorganisms.

The above-mentioned screening test strip reading system, wherein the screening test strip is a new coronary pneumonia screening test strip (COVID-19 IgM/IgG Rapid Test Kit), an immunochromatographic test strip or a biological rapid screening test strip or an immune antibody rapid screening test Screening test paper.

The above screening test paper reading system, wherein the illumination device is a white light-emitting diode (White LED), an ultraviolet light-emitting diode (UV LED), a near-infrared light-emitting diode (NIR LED), a laser Laser diode, Halogen lamp or Tungsten lamp.

The above screening test paper reading system, wherein the optical analysis unit is an optical wavelength spectroscopic device or a spectrum analyzer.

The above screening test paper reading system, wherein the reading device further comprises an imaging amplifying device, and the imaging amplifying device is used to provide a reflection image spectral signal for amplifying the detection line of the reaction area irradiated by the emission light source.

The above-mentioned screening test paper reading system, wherein the imaging magnifying device is composed of a magnifying lens and a refractor.

The above screening test paper reading system, wherein the magnification of the imaging magnification device is selected to be between 1.5 times and 10 times.

The above screening test paper reading system, wherein the detection line is IgM or IgG.

The above-mentioned screening test strip reading system, wherein the displacement platform is further provided with a line rail device, which is used for sliding and displacement of the displacement platform.

The above screening test strip reading system, wherein the displacement riding platform unit further comprises at least one limiting device, wherein the limiting device is a photo-interrupter.

As described above, the screening test paper reading system further comprises a receiving seat, and the receiving seat is used for carrying the reading light unit and the optical analysis unit.

The above screening test strip reading system, wherein the receiving base further comprises a support rod, and the support rod is used for connecting the receiving base and the loading base.

The above screening test strip reading system, wherein the driving device further comprises a motor receiving seat, wherein the motor receiving seat is used for carrying the stepping motor and is connected and fixed to the carrying base.

The above-mentioned screening test strip reading system, wherein the linear rail device further comprises a linear rail receiving seat for fixing the displacement platform on the riding base.

10: A reading light unit

11: Reader

12: Lighting device

100: Screening test strip reading system

101: Magnifying lens

102: Refractor

103: A light receiving channel

20: A screening test strip

30: An optical analysis unit

31: read head

40: A test strip stage unit

41: A carrying area

42: Linkage

50: A displacement riding platform unit

51: A displacement platform

52: A driving device

53: A load base

55: A position sensor

511: One-Line Rail Device

512: One-line rail socket

521: A motor socket

60: A circuit board

70: A receiving seat

71: Support rod

80: Screening test paper

81: Reaction zone

Figure 1 is a schematic diagram of a conventional screening test paper.

Fig. 2 is an exploded view of the three-dimensional structure of the screening test strip reading system of the present invention.

Fig. 3 is a side view of the exploded stack of the structure of the screening test strip reading system of the present invention.

FIG. 4 is a front view of the screening test strip reading system of the present invention.

FIG. 5 is a rear view of the screening test strip reading system of the present invention.

FIG. 6 is a top view of the screening test strip reading system of the present invention.

Fig. 7 is an enlarged view of the imaging magnifying device of the screening test strip reading system of the present invention.

FIG. 8 is a schematic diagram of the reading signal of the test strip of the present invention through the imaging amplifying device.

Certain terms are used in the specification and subsequent claims to refer to particular elements. It should be understood by those of ordinary skill in the art that hardware manufacturers may refer to the same element by different nouns. The scope of this specification and subsequent applications does not take the difference in name as a way to distinguish elements, but takes the difference in function of the elements as a criterion for distinguishing. The reference to "including" throughout the specification and subsequent claims is an open-ended term and should be interpreted as "including but not limited to".

Figures 2 to 8 are a three-dimensional view, a side view of an exploded structure, and an enlarged view of the imaging magnifying device of the screening test paper reading system of the present invention, respectively. As shown in Figure 2, the screening test paper reading system 100 of the present invention, Its main components are composed of a screening test paper 20 , a test paper carrier unit 40 , a reading light unit 10 , a displacement riding platform unit 50 and a circuit board 60 . Referring to an embodiment of the present application as shown in FIG. 2, a screening test paper reading system includes: a reading light unit 10, in addition, a reading device 11 and a light device 12, and read The use of taking light; in addition, there is a screening test paper 20, which is equipped with a reaction area, the reaction area can produce a chemical reaction on a number of specific samples (such as urine or blood, etc.), and Change the color of the detection line in the reaction area, the above-mentioned screening test paper is a new coronary pneumonia screening test paper (COVID-19 IgM/IgG Rapid Test Kit), which can quickly perform new coronary pneumonia screening; an optical analysis unit 30, which is connected to the reader. Take the light unit 10, the optical analysis unit is a miniature spectrum analyzer, used to analyze the spectral signal of the detection line image of the screening test paper reaction area received by the reading device 11; A carrying area 41 is arranged thereon for accommodating the screening test paper 20 and fixing the screening test paper 20 on the test paper carrier unit 40, and the test paper carrier unit 40 is further configured with a linkage portion 42, The linkage part 42 is a rack; a displacement riding platform unit 50 has a displacement platform 51 , a driving device 52 and a loading base 53 for riding the reading light The unit 10, the test strip carrier unit 40, the displacement platform 51 and the driving device 52, the driving device 52 mentioned above is a stepping motor, and the driving device 52 (stepping motor) and the linking part 42 (rack) are mechanically The actuating link is activated, and the displacement platform 51 is moved; and a circuit board unit 60 is electrically connected between the reading and lighting unit 10, the optical analysis unit 30 and the displacement riding platform unit 50, so as to provide the above-mentioned various The use of circuit signal processing of the unit; wherein, the test paper carrier unit 40 is connected and placed on the displacement platform 51. When the screening test paper 20 is placed in the bearing area 41 of the test paper carrier unit 40, the drive The device 52 will be activated and move the displacement platform 51 through the linkage 42, and when the test strip stage unit 40 moves to the reading position of the reading light unit 10, the light device 12 will emit a light source to illuminate The screening test paper 20, the illumination device 12 are white light emitting diodes (White LED), the reading device 11 will read the reaction area illuminated by the emission light source The reflected image spectral signal of the detection line is then sent to the optical analysis unit 30 for calculation and analysis of the reflected image spectral signal. The specific sample of the screening test paper in the above embodiment can be applied to saliva, urine, blood disease , water, food, toxic and harmful substances or microorganisms, wherein the screening test paper in the above-mentioned embodiment can be replaced with an immunochromatographic test paper, a biological quick-screening test paper or an immune antibody quick-screening test paper, wherein the above-mentioned embodiment The lighting device can be replaced by ultraviolet light emitting diode (UV LED), near infrared light emitting diode (NIR LED), laser diode (Laser diode), halogen lamp (Halogen lamp) or tungsten filament lamp Source (Tungsten lamp), the optical analysis unit in the above embodiment can be replaced by an optical wavelength splitting device.

Continuing from the above-mentioned embodiment, as shown in FIG. 3, a side view of the structure of the screening test strip reading system of the present invention is exploded and stacked, wherein the screening test strip reading system 100 further includes a receiving seat 70, wherein the receiving seat 70 is used for The reading light unit 10 and the optical analysis unit 30 are supported, and the receiving base 70 further includes a support rod 71, wherein the support rod 71 is used for supporting and connecting the receiving base 70 on the carrying base 53, and in addition The driving device 52 further includes a motor receiving seat 521 , wherein the motor receiving seat 521 is used to carry the stepping motor and is connected and fixed to the carrying base 30 , and wherein the displacement platform 51 further has a linear rail device 511 , which is used to make the displacement platform 51 slide and displace. In addition, the linear rail device 511 further includes a linear rail receiving seat 512 for fixing the displacement platform 51 on the loading base 53 .

Continuing the above-mentioned embodiment, as shown in Fig. 4, the screening test strip reading system of the present invention is shown in Fig. 4. The front view and FIG. 5 are the rear views of the screening test strip reading system of the present invention, wherein when a screening test strip 20 is placed in the bearing area 41 of the test strip stage unit 40, the driving device of the screening test strip reading system The (stepping motor) 52 will be activated, because the driving device 52 is mechanically activated with the linkage (rack) 42 (as shown in FIG. 5 ), and the test strip stage unit 40 is placed on the On the displacement platform 51, the driving device 52 will drive the linkage portion 42 to move the displacement platform 51, and confirm the area read by the screening test paper, wherein the displacement riding platform unit 50 further includes a position sensing The device 55 is used to sense the relative position of the displacement riding platform unit 50, and the displacement riding platform unit 50 further includes at least one limiting device, wherein the limiting device is a photo-interrupter (not shown in the figure). shown), the above-mentioned position sensor 55 will calculate the reading position and locate the relative position of the limiting device and the test paper stage 40, so that when the test paper stage unit 40 moves to the required reading of the reading light unit 10 take the location.

Continuing from the above embodiment, taking the example of detecting the patient's urine sugar value, if it has been determined that the screening test paper taken is dedicated to urine sugar, the detection can be carried out directly, that is, the reaction between the urine to be tested and the screening test paper 20 is carried out. Contact (usually by dripping or infiltration), the components in the reaction zone will chemically react with the urine to be tested, and change the color of the reaction zone. In addition, the reaction zone can include a variety of different detection zones for detecting glucose, protein, pH value, occult blood value or other physiological values in urine, so as to achieve the effect of screening multiple values at one time. After the urine to be tested contacts the reaction area of the screening test paper, the screening test paper 20 can be placed in the bearing area 41 of the test paper carrier unit 40, and the subsequent optical analysis unit 30 The reading device 11 will read the reflection image spectral signal of the detection line irradiated by the emission light source in the reaction area, and then send it to the optical analysis unit 30 for calculation and analysis of the reflection image spectral signal, as shown in FIG. 6 . The above-mentioned screening test paper 20 shown above can be replaced by a new coronary pneumonia screening test paper (COVID-19 IgM/IgG Rapid Test Kit), wherein the detection line of the screening test paper is IgM or IgG, and the above-mentioned screening test paper can quickly carry out the new crown pneumonia. Pneumonia screening, in addition, the technology of this case can accurately measure the response spectral signal of the object to be tested on the screening test paper, and can achieve the purpose of rapid screening and rapid replacement of the screening test paper, and solve the possibility that the general rapid screening test paper may cause the new crown Error judgment of false negative lines of pneumonia epidemic.

Continuing from the above-mentioned embodiment, in the screening test strip reading system of the present invention, the reading device 11 further includes an imaging magnifying device, and the imaging magnifying device is used to provide a means of magnifying the detection line of the reaction area irradiated by the emission light source. The reflected image spectral signal is used, as shown in FIG. 7, wherein the imaging magnifying device is composed of a magnifying lens 101 and a refractor 102, wherein the magnification of the imaging magnifying device is selected to be between 1.5 times and 10 times, wherein When the reading device 11 reads the spectral signal of the reflected image of the detection line irradiated by the emitting light source in the reaction area, the spectral signal of the reflected image of the detected line will first pass through the magnifying lens 101 and the refractor 102 and a light receiving channel After 103 amplifying the signal, it will be transmitted to the read head 31 of the optical analysis unit to receive and then perform subsequent optical analysis.

As shown in FIG. 8 , following the above-mentioned embodiment, when the reading device 11 reads the reflected image spectral signal of the detection line irradiated by the emitting light source in the reaction area, the amplification of the imaging amplifying device as selected in the embodiment of the present case is performed. The magnification is 3.5 When the original reading detection line reflected image has a width of 1 mm and is magnified by the imaging amplifying device, the image signal received by the read head 31 of the optical analysis unit becomes 3.5 mm, and the optical analysis unit 30 subsequently The received amplified signal is analyzed, and the above-mentioned device can solve the problem and avoid the occurrence of the product of the detection line of the new coronary pneumonia screening test paper, immunochromatographic test paper, biological quick screening test paper or immune antibody quick screening test paper. After reacting with the analyte, there is no color development or the line is not obvious or may cause a false negative line condition, thereby causing an error judgment of the detection.

For the above-mentioned exemplary embodiment, the screening test strip reading system of the present invention can solve the false negative error judgment and the user can use the test strip carrier unit 40 to quickly replace the screening test paper 20 to achieve the purpose of repeated screening.

After describing the above preferred embodiments of the present invention in detail, those skilled in the art can clearly understand that various changes and changes can be made without departing from the scope and spirit of the following patent applications, such as various implementations of the limit unit Such and the like are not limited to the implementation of the embodiments of the description.

10: A reading light unit

100: Screening test strip reading system

20: A screening test strip

30: An optical analysis unit

40: A test strip stage unit

41: A carrying area

42: Linkage

50: A displacement riding platform unit

51: A displacement platform

52: A driving device

53: A load base

55: A position sensor

511: One-Line Rail Device

512: One-line rail socket

521: A motor socket

60: A circuit board

70: A receiving seat

71: Support rod

Claims (18)

A screening test strip reading system, comprising: a reading and lighting unit, having a reading device and a lighting device; A screening test paper, with a reaction area configured on it, the reaction area can produce chemical reactions to a number of specific samples, and change the color of the detection line in the reaction area; an optical analysis unit, connected to the reading light unit, for analyzing the spectral signal of the detection line image of the screening test paper reaction area received by the reading device; a test paper carrier unit, which is provided with a bearing area for accommodating the screening test paper and fixing the screening test paper on the test paper carrier unit, and the test paper carrier unit is further provided with a linkage part; A displacement riding platform unit, which has a displacement platform, a driving device and a loading base, the loading base is used for riding the reading light unit, the test strip loading platform unit, the displacement platform and the driving device, and in addition The driving device is operatively connected with the linkage part; and a circuit board unit is electrically connected between the reading and lighting unit, the optical analysis unit and the displacement riding platform unit to provide circuit signal processing of the above-mentioned units ; Wherein, the test paper carrier unit is connected and placed on the displacement platform. When the screening test paper is placed in the bearing area of the test paper carrier unit, the driving device will be activated and the displacement multiplier will be multiplied by the linkage part. The carrier platform unit moves, and when the test paper carrier unit moves to the reading position of the reading illuminating unit, the illuminating device will emit a light source to illuminate the screening test paper, and the reading device will read through the emitting light source The detection line irradiated on the reaction area reflects the spectral signal of the image, and is subsequently sent to the optical analysis unit for calculation and analysis of the spectral signal of the reflected image. According to the screening test paper reading system of claim 1, the displacement riding platform unit further includes a position sensor for sensing the relative position of the displacement riding platform unit. According to the screening test strip reading system of claim 1, wherein the driving device is a step motor. According to the screening test strip reading system of claim 1, wherein the linkage part is a rack. For example, the screening test strip reading system according to item 1 of the patent scope is applied for, wherein the specific sample application of the screening test strip is saliva, urine, blood plague, water, food, toxic and harmful substances or microorganisms. For example, the screening test strip reading system of item 1 of the patent scope is applied, wherein the screening test strip is a new coronary pneumonia screening test strip (COVID-19 IgM/IgG Rapid Test Kit), an immunochromatographic test strip or a biological rapid screening test strip Or immune antibody rapid screening test strips. According to the screening test paper reading system of claim 1, wherein the illumination device is a white light-emitting diode (White LED), an ultraviolet light-emitting diode (UV LED), a near-infrared light-emitting diode (NIR) LED), Laser diode, Halogen lamp or Tungsten lamp. According to the screening test paper reading system of claim 1, wherein the optical analysis unit is an optical wavelength spectroscopic device or a spectrum analyzer. The screening test paper reading system of claim 1, wherein the reading device further comprises an imaging magnifying device, and the imaging magnifying device is used to provide a reflection image spectrum for magnifying the detection line of the reaction area irradiated by the emission light source signal usage. According to the screening test paper reading system of claim 9, the imaging magnifying device is composed of a magnifying lens and a refractor. According to the screening test paper reading system of claim 10, wherein the magnification of the imaging magnification device is selected to be between 1.5 times and 10 times. According to the screening test strip reading system of claim 1, wherein the detection line is IgM or IgG. According to the screening test paper reading system of claim 1, wherein the displacement platform is further provided with a line rail device, which is used for sliding and displacement use of the displacement platform. The screening test strip reading system of claim 2, wherein the displacement riding platform unit further comprises at least one limiting device, wherein the limiting device is a photo-interrupter. The screening test paper reading system of claim 1 of the patent application scope further comprises a receiving seat, and the receiving seat is used for carrying the reading light unit and the optical analysis unit. The screening test strip reading system of claim 15, wherein the receiving base further comprises a support rod, and the support rod is used for connecting the receiving base and the carrying base. The screening test strip reading system of claim 3, wherein the driving device further comprises a motor receiving seat, wherein the motor receiving seat is used for carrying the stepping motor and is connected and fixed to the carrying base. As claimed in claim 13, the screening test strip reading system, wherein the linear rail device further comprises a linear rail receiving seat for fixing the displacement platform on the riding base.

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